Reference on EC 3.4.24.14 - procollagen N-endopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Leung, M.K.K.; Fessler, L.I.; Greenberg, D.B.; Fessler, J.H.
Separate amino and carboxyl procollagen peptidases in chick embryo tendon
J. Biol. Chem.
254
224-232
1979
Gallus gallus
Hojima, Y.; Behta, B.; Romanic, A.M.; Prockop, D.J.
Cadmium ions inhibit procollagen C-proteinase and cupric ions inhibit procollagen N-proteinase
Matrix Biol.
14
113-120
1994
Gallus gallus
Dombrowski, K.E.; Vogel, B.E.; Prockop, D.J.
Mutations that alter the primary structure of type I procollagen have long-range effects on its cleavage by procollagen N-proteinase
Biochemistry
28
7107-7112
1989
Gallus gallus
Hojima, Y.; McKenzie, J.A.; Van der Rest, M.; Prockop, D.J.
Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides
J. Biol. Chem.
264
11336-11345
1989
Bos taurus, Gallus gallus
Dombrowski, K.E.; Prockop, D.J.
Cleavage of type I and type II procollagens by type I/II procollagen N-proteinase. Correlation of kinetic constants with the predicted conformations of procollagen substrates
J. Biol. Chem.
263
16545-16552
1988
Gallus gallus
Dombrowski, K.E.; Sheats, J.E.; Prockop, D.J.
Iron-containing metallocenes as active site directed inhibitors of the proteinase that cleaves the NH2-terminal propeptides from type I procollagen
Biochemistry
25
4302-4309
1986
Gallus gallus
Tanzawa, K.; Berger, J.; Prockop, D.J.
Type I procollagen N-proteinase from whole chick embryos. Cleavage of a homotrimer of pro-alpha 1(I) chains and the requirement for procollagen with a triple-helical conformation
J. Biol. Chem.
260
1120-1126
1985
Gallus gallus
Prockop, D.L.; Sieron, A.L.; Li, S.W.
Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling
Matrix Biol.
16
399-408
1998
Bos taurus, Gallus gallus
Tuderman, L.; Prockop, D.J.
Procollagen N-proteinase. Properties of the enzyme purified from chick embryo tendons
Eur. J. Biochem.
125
545-549
1982
Gallus gallus
Prockop, D.J.; Tuderman, L.
Posttranslational enzymes in the biosynthesis of collagen: extracellular enzymes
Methods Enzymol.
82
305-319
1982
Bos taurus, Gallus gallus
Arnold, W.V.; Fertala, A.; Sieron, A.L.; Hattori, H.; Mechling, D.; Bchinger, H.P.; Prockop.D.L.
Recombinant procollagen II: Deletion of D period segments identifies sequences that are required for helix stabilization and generates a temperature-sensitive N-proteinase cleavage site
J. Biol. Chem.
273
31822-31828
1998
Bos taurus, Gallus gallus
Nusgens, B.; Lapiere, C.M.
A simplified procedure for measuring amino-procollagen peptidase type I
Anal. Biochem.
95
406-412
1979
Bos taurus, Gallus gallus
Tuderman, L.; Kivirikko, K.I.; Prockop, D.J.
Partial purification and characterization of a neutral protease which cleaves the N-terminal propeptides from procollagen
Biochemistry
17
2948-2954
1978
Gallus gallus
Kohn, L.D.; Isersky, C.; Zupnik, J.; Lenaers, A.; Lee, G.; Lapiere, C.M.
Calf tendon procollagen peptidase: its purification and endopeptidase mode of action
Proc. Natl. Acad. Sci. USA
71
40-44
1974
Bos taurus
Hojima, Y.; Morgelin, M.M.; Engel, J.; Boutillon, M.M.; Van der Rest, M.; McKenzie, J.; Chen, G.C.; Rafi, N.; Romanic, A.M.; Prockop, D.J.
Characterization of type I procollagen N-proteinase from fetal bovine tendon and skin. Purification of the 500-kilodalton form of the enzyme from bovine tendon
J. Biol. Chem.
269
11381-11390
1994
Bos taurus
Colige, A.; Beschin, A.; Damyn, B.; Goebels, Y.; Van Beeumen, J.; Nusgens, B.V.; Lapiere, C.M.
Characterization and partial amino acid sequencing of a 107-kDa procollagen I N-proteinase purified by affinity chromatography on immobilized type XIV collagen
J. Biol. Chem.
270
16725-16730
1995
Bos taurus
-
Kadler, E.K.; Lightfoot, S.J.; Watson, R.B.
Procollagen N-peptidases: procollagen N-proteinases
Methods Enzymol.
248
756-771
1995
Bos taurus, Gallus gallus
Lightfoot, S.J.; Holmes, D.F.; Brass, A.; Grant, M.; Byers, P.H.; Kadler, K.E.
Type I procollagens containing substitutions of aspartate, arginine, and cysteine for glycine in the pro alpha 1 (I) chain are cleaved slowly by N-proteinase, but only the cysteine substitution introduces a kink in the molecule
J. Biol. Chem.
267
25521-25528
1992
Gallus gallus
Colige, A.; Li, S.W.; Sieron, A.L.; Nusgens, B.V.; Prockop, D.J.
cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components
Proc. Natl. Acad. Sci. USA
94
2374-2379
1997
Bos taurus (P79331), Bos taurus
Wang, W.M.; Ge, G.; Lim, N.H.; Nagase, H.; Greenspan, D.S.
TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2
Biochem. J.
398
515-519
2006
Homo sapiens
Colige, A.
Procollagen III N-proteinase
Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
458-460
2004
Bos taurus, Homo sapiens
-
Colige, A.
Procollagen N-endopeptidase, ADAMTS2
Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
737-740
2004
Bos taurus, Gallus gallus, Homo sapiens
-
Colige, A.; Ruggiero, F.; Vandenberghe, I.; Dubail, J.; Kesteloot, F.; Van Beeumen, J.; Beschin, A.; Brys, L.; Lapiere, C.M.; Nusgens, B.
Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V
J. Biol. Chem.
280
34397-34408
2005
Bos taurus
Hultstroem, M.; Leh, S.; Skogstrand, T.; Iversen, B.M.
Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage
Nephrol. Dial. Transplant.
23
896-903
2008
Rattus rattus
Langsjoe, T.K.; Arita, M.; Helminen, H.J.
Cartilage collagen fibril network in newborn transgenic mice analyzed by electron microscopic stereology
Cells Tissues Organs
190
209-218
2009
Mus musculus
Canty-Laird, E.G.; Lu, Y.; Kadler, K.E.
Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts in situ
Biochem. J.
441
707-717
2012
Gallus gallus
Dubail, J.; Kesteloot, F.; Deroanne, C.; Motte, P.; Lambert, V.; Rakic, J.M.; Lapiere, C.; Nusgens, B.; Colige, A.
ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity
Cell. Mol. Life Sci.
67
4213-4232
2010
Bos taurus
Bekhouche, M.; Colige, A.
The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology
Matrix Biol.
44-46C
46-53
2015
Gallus gallus, Rattus norvegicus (D3ZTE7), Bos taurus (E1BC50), Bos taurus (E1BFV4), Bos taurus (P79331), Canis lupus familiaris (E2R8G2), Sus scrofa (I3LAK9), Homo sapiens (O15072), Homo sapiens (O95450), Homo sapiens (Q8WXS8), Mus musculus (Q8C9W3), Ovis aries (W5P0Z2)
Bekhouche, M.; Leduc, C.; Dupont, L.; Janssen, L.; Delolme, F.; Vadon-Le Goff, S.; Smargiasso, N.; Baiwir, D.; Mazzucchelli, G.; Zanella-Cleon, I.; Dubail, J.; De Pauw, E.; Nusgens, B.; Hulmes, D.J.; Moali, C.; Colige, A.
Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-beta signaling as primary targets
FASEB J.
30
1741-1756
2016
Homo sapiens (O15072), Homo sapiens (O95450), Homo sapiens (Q8WXS8), Homo sapiens
Wang, X.; Chen, W.; Zhang, J.; Khan, A.; Li, L.; Huang, F.; Qiu, Z.; Wang, L.; Chen, X.
Critical role of ADAMTS2 (a disintegrin and metalloproteinase with thrombospondin motifs 2) in cardiac hypertrophy induced by pressure overload
Hypertension
69
1060-1069
2017
Homo sapiens (O95450), Homo sapiens, Rattus norvegicus (P16636), Mus musculus (Q8C9W3), Mus musculus
Bekhouche, M.; Colige, A.
The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology
Matrix Biol.
44-46
46-53
2015
Homo sapiens (O15072), Homo sapiens (O95450), Homo sapiens (Q8WXS8), Mus musculus (Q8C9W3)
Colige, A.C.
Purification of native or recombinant ADAMTS2, and procollagen I cleavage assay
Methods Mol. Biol.
2043
55-62
2020
Bos taurus (P79331), Homo sapiens (O95450), Homo sapiens
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