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Disease on EC 3.4.22.62 - caspase-9

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Caspase-9-dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2.
Acute Kidney Injury
Protective Effect of Taurine on Mice with Doxorubicin-induced Acute Kidney Injury.
Adenocarcinoma
Activity of selenium on cell proliferation, cytotoxicity, and apoptosis and on the expression of CASP9, BCL-XL and APC in intestinal adenocarcinoma cells.
Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis.
Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.
Cytotoxic and Antimicrobial Evaluations of Novel Apoptotic and Anti-Angiogenic Spiro Cyclic 2-Oxindole Derivatives of 2-Amino-tetrahydroquinolin-5-one.
Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated from Sphaerococcus coronopifolius.
Dysregulated Expression of Apoptosis-Associated Genes and MicroRNAs and Their Involvement in Gastric Carcinogenesis.
Expression analysis of caspase-6, caspase-9 and BNIP3 in prostate cancer.
Immune clearance gastric carcinoma cells in ascites by activating caspase-9-induced apoptosis.
Immunohistochemical analysis of cell death pathways in gastrointestinal adenocarcinoma.
Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis.
[Changes in the number of copies of genetic loci in gastric cancer].
Adenocarcinoma of Lung
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.
Immunocytochemical expression of a panel of markers in pleural effusions from patients with primary lung adenocarcinoma.
Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas.
Resveratrol induces apoptosis via a Bak-mediated intrinsic pathway in human lung adenocarcinoma cells.
The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells.
Aggressive Periodontitis
The role of caspase-8, caspase-9, and apoptosis inducing factor in periodontal disease.
Alopecia
Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss.
Altitude Sickness
[Studies on apoptosis and caspase-8 and caspase-9 expressions of bone marrow cells in chronic mountain sickness].
Alzheimer Disease
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.
Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain.
The silent information regulator 1 pathway attenuates ROS-induced oxidative stress in Alzheimer's disease.
[Neuroprotective effect of ginsenoside Rb-1 on a rat model of Alzheimer's disease].
Ameloblastoma
Detection of mitochondria-mediated apoptosis signaling molecules in ameloblastomas.
Amyotrophic Lateral Sclerosis
Identification and verification of key genes in varicocele rats through high-throughput sequencing and bioinformatics analysis.
MAPT (Tau) expression is a biomarker for an increased rate of survival in pediatric neuroblastoma.
Serum caspase-9 levels are increased in patients with amyotrophic lateral sclerosis.
Anemia
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Aneurysm
Down-regulation of apoptosis after left ventricular aneurysm repair.
Intrinsic Pathway-Mediated Apoptosis in Elastase-Induced Aneurysms in Rabbits.
The protective effect of puerarin on angiotensin II-induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress-triggered AP-1 signaling pathways.
Arteritis
The equine arteritis virus induces apoptosis via caspase-8 and mitochondria-dependent caspase-9 activation.
Asthma
Activation of Bcl-2-Caspase-9 Apoptosis Pathway in the Testis of Asthmatic Mice.
Astrocytoma
CASP9 Germline Mutation in a Family with Multiple Brain Tumors.
The role of caspases 9 and 9-short (9S) in death ligand- and drug-induced apoptosis in human astrocytoma cells.
Ataxia
Investigation of the Anticancer Mechanism of Isoorientin Isolated from Eremurus Spectabilis Leaves via Cell Cycle Pathways in HT-29 Human Colorectal Adenocarcinoma Cells.
Ataxia Telangiectasia
A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma.
Cyto-/genotoxic effect of CdSe/ZnS quantum dots in human lung adenocarcinoma cells for potential photodynamic UV therapy applications.
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
Ionizing radiation-induced apoptosis in ataxia-telangiectasia fibroblasts. Roles of caspase-9 and cellular inhibitor of apoptosis protein-1.
Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells.
Tannic Acid Induces the Mitochondrial Pathway of Apoptosis and S Phase Arrest in Porcine Intestinal IPEC-J2 Cells.
Tetrandrine Enhances H2O2-Induced Apoptotic Cell Death Through Caspase-dependent Pathway in Human Keratinocytes.
Atherosclerosis
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease.
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1?/ER? pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
Inhibitory Effects of Ginsenoside Rb1 on Early Atherosclerosis in ApoE-/- Mice via Inhibition of Apoptosis and Enhancing Autophagy.
Quantitative analysis of the expression of caspase 3 and caspase 9 in different types of atherosclerotic lesions in the human aorta.
Atrial Fibrillation
Mitochondrial apoptotic pathway activation in the atria of heart failure patients due to mitral and tricuspid regurgitation.
Autoimmune Diseases
An inducible caspase 9 safety switch can halt cell therapy-induced autoimmune disease.
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease.
Autoimmune Lymphoproliferative Syndrome
ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.
The autoimmune conundrum in common variable immunodeficiency disorders.
Bacterial Infections
Glucose-6-phosphate dehydrogenase (G6PD)-deficient epithelial cells are less tolerant to infection by Staphylococcus aureus.
Lrcasp9 shares similarity in structural motifs with human caspase-9 and is activated following bacterial infection and anti-viral vaccination.
Blast Crisis
Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro.
Bone Resorption
Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro.
Radiation alters osteoclastogenesis by regulating the cytoskeleton and lytic enzymes in RAW 264.7 cells and mouse bone marrow-derived macrophages.
Brain Edema
Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis.
Reduction of Autophagosome Overload Attenuates Neuronal Cell Death After Traumatic Brain Injury.
Brain Injuries
Caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia.
Caspase-9.
Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death.
Inhibiting caspase-9 after injury reduces hypoxic ischemic neuronal injury in the cortex in the newborn rat.
Mitochondrial impairment in the developing brain after hypoxia-ischemia.
Neuroprotection against hypoxic-ischemic brain injury by inhibiting the apoptotic protease activating factor-1 pathway.
Treatment of hypoxic-ischemic brain injury in newborn rats with TPCK 3 h after hypoxia decreases caspase-9 activation and improves neuropathologic outcome.
[The expression of Smac and XIAP in rat hippocampus following limbic seizure induced by kainic acid injection into amygdaloid nucleus]
Brain Injuries, Traumatic
Detectable levels of cytochrome C and activated caspase-9 in cerebrospinal fluid after human traumatic brain injury.
Pathways leading to apoptotic neurodegeneration following trauma to the developing rat brain.
Brain Ischemia
Analysis of Caspase-9 protein and microRNAs miR-21, miR-126 and miR-155 related to the apoptosis mechanism in the cerebellum of rats submitted to focal cerebral ischemia associated with an alcoholism model.
Caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia.
Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia.
Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice.
PDZ1 inhibitor peptide protects neurons against ischemia via inhibiting GluK2-PSD-95-module-mediated Fas signaling pathway.
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.
The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia.
[Effect of electroacupuncture on caspase-9 expression in hippocampus and neuroethology in hyperlipemia rats with concurrent cerebral ischemia]
Brain Neoplasms
CASP9 Germline Mutation in a Family with Multiple Brain Tumors.
Role of Caspase-9 Gene Ex5+32 G>A (rs1052576) Variant in Susceptibility to Primary Brain Tumors.
Breast Neoplasms
2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway.
Adenosine and deoxyadenosine induces apoptosis in oestrogen receptor-positive and -negative human breast cancer cells via the intrinsic pathway.
Adenovirus-mediated p53 and ING4 gene co?transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer.
Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase/Akt signaling in human breast cancer cells.
Anti-miR-203 Upregulates SOCS3 Expression in Breast Cancer Cells and Enhances Cisplatin Chemosensitivity.
Anticancer activities of pterostilbene-isothiocyanate conjugate in breast cancer cells: involvement of PPAR?.
Apoptosis Cell Death Effect of Scrophularia Variegata on Breast Cancer Cells via Mitochondrial Intrinsic Pathway.
Apoptosis-inducing and antiproliferative effect by inhibition of miR-182-5p through the regulation of CASP9 expression in human breast cancer.
Apoptotic effect of noscapine in breast cancer cell lines.
Application of constrained aza-valine analogs for Smac mimicry.
Artesunate, as a HSP70 ATPase activity inhibitor, induces apoptosis in breast cancer cells.
Association of LncRNA-GACAT3 with MRI features of breast cancer and its molecular mechanism.
Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation.
Caspase 9 promoter polymorphisms confer increased susceptibility to breast cancer.
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
Cell death induced by taxanes in breast cancer cells: cytochrome C is released in resistant but not in sensitive cells.
Chemotherapy with hybrid liposomes for human breast tumors along with apoptosis in vivo.
Cytotoxic activity of octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives in human breast cancer cells.
d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway.
Debio-0932, a second generation oral Hsp90 inhibitor, induces apoptosis in MCF-7 and MDA-MB-231 cell lines.
Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells.
DIRECT INDUCTION OF APOPTOSIS USING AN OPTIMAL MITOCHONDRIALLY TARGETED P53.
Dissection of signaling pathways in fourteen breast cancer cell lines using reverse-phase protein lysate microarray.
Ectopic expression of cyclin D1 amplifies a retinoic acid-induced mitochondrial death pathway in breast cancer cells.
Effects of geranyl-phloroacetophenone on the induction of apoptosis and chemosensitization of adriamycin-resistant MCF-7 human breast cancer cells.
Embryonic morphogen nodal promotes breast cancer growth and progression.
Emetine regulates the alternative splicing of caspase 9 in tumor cells.
EMP1, a member of a new family of antiproliferative genes in breast carcinoma.
Enhancement of tumor necrosis factor-alpha-induced growth inhibition by insulin-like growth factor-binding protein-5 (IGFBP-5), but not IGFBP-3 in human breast cancer cells.
Enterocarpam-III induces human liver and breast cancer cell apoptosis via mitochondrial and caspase-9 activation.
Equol induces apoptosis through cytochrome c-mediated caspases cascade in human breast cancer MDA-MB-453 cells.
Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-X(L) expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation.
Expression and prognostic significance of osteopontin and caspase-3 in hepatocellular carcinoma patients after curative resection.
Fabrication of methotrexate-loaded gold nanoconjugates and its enhanced anticancer activity in breast cancer.
Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9.
Halilectin-3, a lectin from the marine sponge Haliclona caerulea, induces apoptosis and autophagy in human breast cancer MCF7 cells through caspase-9 pathway and LC3-II protein expression
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Induction of Apoptosis and Autophagy by Ternary Copper Complex Towards Breast Cancer Cells.
Inflammation and IGF-I activate the Akt pathway in breast cancer.
Inhibitory effects of combination of lycopene and genistein on 7,12- dimethyl benz(a)anthracene-induced breast cancer in rats.
Involvement of caspase-9 but not caspase-8 in the anti-apoptotic effects of estradiol and 4-OH-Estradiol in MCF-7 human breast cancer cells.
LncRNA POU3F3 promotes proliferation and inhibits apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9.
Myricetin Apoptotic Effects on T47D Breast Cancer Cells is a P53-Independent Approach.
Myricetin Exerts its Apoptotic Effects on MCF-7 Breast Cancer Cells through Evoking the BRCA1-GADD45 Pathway.
Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
Oxaliplatin-chitosan nanoparticles induced intrinsic apoptotic signaling pathway: A "smart" drug delivery system to breast cancer cell therapy.
Oxymatrine Promotes S-Phase Arrest and Inhibits Cell Proliferation of Human Breast Cancer Cells in Vitro through Mitochondria-Mediated Apoptosis.
Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer.
PQ1, a quinoline derivative, induces apoptosis in T47D breast cancer cells through activation of caspase-8 and caspase-9.
Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells.
Rapid Upregulation of Cytoprotective Nitric Oxide in Breast Tumor Cells Subjected to a Photodynamic Therapy-like Oxidative Challenge.
Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9.
Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells.
Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells.
Roles of the Bcl-2/Bax ratio, caspase-8 and 9 in resistance of breast cancer cells to paclitaxel.
RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria.
Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer.
Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis.
Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin.
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines.
Super Magnetic Niosomal Nanocarrier as a New Approach for Treatment of Breast Cancer: A Case Study on SK-BR-3 and MDA-MB-231 Cell Lines.
Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models.
Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study.
Tamoxifen and TRAIL synergistically induce apoptosis in breast cancer cells.
Targeted inhibition of Notch1 gene enhances the killing effects of paclitaxel on triple negative breast cancer cells.
Taxol-induced apoptosis in human SKOV3 ovarian and MCF7 breast carcinoma cells is caspase-3 and caspase-9 independent.
The anticancer effect and mechanism of ?-hederin on breast cancer cells.
The differential sensitivity of Bc1-2-overexpressing human breast tumor cells to TRAIL or doxorubicin-induced apoptosis is dependent on Bc1-2 protein levels.
The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells.
Transcript expression and genetic variability analysis of caspases in breast carcinomas suggests CASP9 as the most interesting target.
Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS.
Tumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo.
Typhonium flagelliforme extract induce apoptosis in breast cancer stem cells by suppressing survivin.
[Apoptosis resistance induced by leptin and its mechanism in breast cancer cells]
[Clinical and Functional Importance of Selected CASP8 and CASP9 Polymorphisms in Breast Carcinoma].
[Hirsutine induces apoptosis of human breast cancer MDA-MB-231 cells through mitochondrial pathway].
Carcinogenesis
Association of CASP9, CASP10 gene polymorphisms and tea drinking with colorectal cancer risk in the Han Chinese population.
Beclin 1-mediated macroautophagy involves regulation of caspase-9 expression in cervical cancer HeLa cells.
Caspase inhibition blocks cell death and enhances mitophagy but fails to promote T-cell lymphoma.
Chemopreventive activity of Azadirachta indica on two-stage skin carcinogenesis in murine model.
Chemopreventive activity of Hydroethanolic Murraya koenigii leaves extract (HEMKLE) against chemically induced skin carcinogenesis in mice.
Chemopreventive efficacy of hesperidin against chemically induced nephrotoxicity and renal carcinogenesis via amelioration of oxidative stress and modulation of multiple molecular pathways.
Effects of treatment of rats with indole-3-carbinol on apoptosis in the mammary gland and mammary adenocarcinomas.
Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila.
Living or dying by RNA processing: caspase expression in NSCLC.
Magnetite (Fe(3)O(4)) nanocrystals affect the expression of genes involved in the TGF-beta signalling pathway.
MicroRNA-224 Promotes Tumorigenesis through Downregulation of Caspase-9 in Triple-Negative Breast Cancer.
The potential tumour suppressor role for caspase-9 (CASP9) in the childhood malignancy, neuroblastoma.
[A study on the expression of CASP9 gene and its polymorphism distribution in non-small cell lung cancer]
Carcinoma
125I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts.
?-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor.
A novel mechanism of CD40-induced apoptosis of carcinoma cells involving TRAF3 and JNK/AP-1 activation.
Antiproliferative and Apoptotic Effects of Shemamruthaa, a Herbal Preparation, in 7,12-Dimethylbenz(a)Anthracene-Induced Breast Cancer Rats.
Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage.
Atiprimod is an inhibitor of cancer cell proliferation and angiogenesis.
Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.
Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.
CASP9 c.-1339A>G and CASP3 c.-1191A>G polymorphisms alter susceptibility and clinical aspects of head and neck squamous cell carcinoma.
Caspase-9 regulates cisplatin-induced apoptosis in human head and neck squamous cell carcinoma cells.
CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma.
Comparative evaluation of antiproliferative, antiangiogenic and apoptosis inducing potential of black tea polyphenols in the hamster buccal pouch carcinogenesis model.
Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-?-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells.
CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through bim-mediated intrinsic apoptosis.
Dasatinib reduces 5-Fu-triggered apoptosis in colon carcinoma by directly modulating Src-dependent caspase-9 phosphorylation.
Defining characteristics of Types I and II apoptotic cells in response to TRAIL.
Degradation of Sargassum crassifolium Fucoidan by Ascorbic Acid and Hydrogen Peroxide, and Compositional, Structural, and In Vitro Anti-Lung Cancer Analyses of the Degradation Products.
Exogenous morphine inhibits human gastric cancer MGC- 803 cell growth by cell cycle arrest and apoptosis induction.
Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: Caspase-8 and caspase-9 is associated with poor prognosis.
Expression and Prognostic Significance of Livin, Caspase-3, and Ki-67 in the Progression of Human Ampullary Carcinoma.
Expression of apoptosis-related proteins caspase-6, caspase-9, FLIP and BNIP3 in oesophageal squamous cell carcinomas.
Expression of phosphorylated caspase-9 in gastric carcinomas.
Fas/FasL of pacific cod mediated apoptosis.
Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas.
Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities.
Immune clearance gastric carcinoma cells in ascites by activating caspase-9-induced apoptosis.
In vivo photoacoustic imaging of chemotherapy-induced apoptosis in squamous cell carcinoma using a near-infrared caspase-9 probe.
Influence of CASP9 c.-1339A>G and CASP3 c.-1191A>G variants in outcome of patients with head and neck squamous cell carcinoma.
Influence of survivin (BIRC5) and caspase-9 (CASP9) functional polymorphisms in renal cell carcinoma development: a study in a southern European population.
Influence of Tanshinone IIA on apoptosis of human esophageal carcinoma Eca-109 cells and its molecular mechanism.
Inhibition of caspase-9 activity and Apaf-1 expression in cisplatin-resistant head and neck squamous cell carcinoma cells.
Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.
Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.
Melatonin influences pancreatic cancerogenesis.
Modulating effect of hesperetin on the molecular expression pattern of apoptotic and cell proliferative markers in 7,12-dimethylbenz(a)anthracene-induced oral carcinogenesis.
Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas.
p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation.
Physcion from marine-derived fungus Microsporum sp. induces apoptosis in human cervical carcinoma HeLa cells.
Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549).
Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration.
Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis.
Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma.
Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression.
The anti-tumour activity of rLj-RGD4, an RGD toxin protein from Lampetra japonica, on human laryngeal squamous carcinoma Hep-2 cells in nude mice.
The association of taxane resistance genes with the clinical course of ovarian carcinoma.
The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation.
Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells.
Up-regulation of FLIP in cisplatin-selected HeLa cells causes cross-resistance to CD95/Fas death signalling.
[Effects of salinomycin on proliferation and apoptosis of oral squamous cell carcinoma].
[Inhibition of caspase-9 activity in cisplatin-resistant head and neck squamous cell carcinoma]
[Study on the effects of mitochondrial pathways on apoptosis in colon carcinoma cells induced by tumor necrosis factor related apoptosis inducing ligand]
Carcinoma, Embryonal
Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9.
BMP-4 and retinoic acid synergistically induce activation of caspase-9 and cause apoptosis of P19 embryonal carcinoma cells cultured as a monolayer.
ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.
RC-6 ribonuclease induces caspase activation, cellular senescence and neuron-like morphology in NT2 embryonal carcinoma cells.
Carcinoma, Hepatocellular
Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects.
Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.
Combination Suicide Gene Delivery with an Adeno-Associated Virus Vector Encoding Inducible Caspase-9 and a Chemical Inducer of Dimerization Is Effective in a Xenotransplantation Model of Hepatocellular Carcinoma.
FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation.
In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells.
Isolation of 4,4'-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma.
LINC01980 stimulates the progression of hepatocellular carcinoma via downregulating caspase 9.
Mitochondria-mediated tumstatin peptide-induced HepG2 cell apoptosis.
Oncogenic miR-96-5p inhibits apoptosis by targeting the caspase-9 gene in hepatocellular carcinoma.
Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway.
Solamargine triggers hepatoma cell death through apoptosis.
Synergistic Antitumor Effect of 5-Fluorouracil Combined with Constituents from Pleurospermum lindleyanum in Hepatocellular carcinoma SMMC-7721 Cells.
Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response.
Carcinoma, Non-Small-Cell Lung
?-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells.
hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing.
Investigation of Caspase 9 Gene Polymorphism in Patients With Non-small Cell Lung Cancer.
Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance.
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo.
Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small cell lung cancer cells: a small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3 activation.
SRSF1 Regulates the Alternative Splicing of Caspase 9 Via A Novel Intronic Splicing Enhancer Affecting the Chemotherapeutic Sensitivity of Non-Small Cell Lung Cancer Cells.
Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer.
The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand.
[A study on the expression of CASP9 gene and its polymorphism distribution in non-small cell lung cancer]
Carcinoma, Renal Cell
Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage.
Influence of survivin (BIRC5) and caspase-9 (CASP9) functional polymorphisms in renal cell carcinoma development: a study in a southern European population.
Carcinoma, Squamous Cell
Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines.
Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.
CASP9 c.-1339A>G and CASP3 c.-1191A>G polymorphisms alter susceptibility and clinical aspects of head and neck squamous cell carcinoma.
Caspase-9 regulates cisplatin-induced apoptosis in human head and neck squamous cell carcinoma cells.
Expression of apoptosis-related proteins caspase-6, caspase-9, FLIP and BNIP3 in oesophageal squamous cell carcinomas.
In vivo photoacoustic imaging of chemotherapy-induced apoptosis in squamous cell carcinoma using a near-infrared caspase-9 probe.
Influence of CASP9 c.-1339A>G and CASP3 c.-1191A>G variants in outcome of patients with head and neck squamous cell carcinoma.
Inhibition of caspase-9 activity and Apaf-1 expression in cisplatin-resistant head and neck squamous cell carcinoma cells.
Modulating effect of hesperetin on the molecular expression pattern of apoptotic and cell proliferative markers in 7,12-dimethylbenz(a)anthracene-induced oral carcinogenesis.
Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis.
Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma.
[Inhibition of caspase-9 activity in cisplatin-resistant head and neck squamous cell carcinoma]
Cardiomegaly
Fatty acid-binding protein 4 silencing protects against lipopolysaccharide-induced cardiomyocyte hypertrophy and apoptosis by inhibiting the Toll-like receptor 4-nuclear factor-?B pathway.
Intramyocardial VEGF-B167 Gene Delivery Delays the Progression Towards Congestive Failure in Dogs With Pacing-Induced Dilated Cardiomyopathy.
Cardiomyopathies
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease.
Cardiotoxicity
?-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish.
caspase-6 deficiency
Caspase regulation of genotoxin-induced neural precursor cell death.
caspase-8 deficiency
ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.
caspase-9 deficiency
Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment.
Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways.
Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarization.
Caspase-9 acts as a regulator of necroptotic cell death.
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development.
Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling.
The autoimmune conundrum in common variable immunodeficiency disorders.
Cataract
Effects of ELL-associated factor 2 on ultraviolet radiation-induced cataract formation in mice.
Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9.
Role of the intrinsic apoptotic pathway in cataractogenesis in type 2 diabetic patients.
Cell Transformation, Neoplastic
Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives.
Cerebral Hemorrhage
[Effect of manual acupuncture of "Shuigou" (GV26)"Neiguan" (PC6) on neurological function and expression of apoptosis-related factors in brain tissues surrounding hematoma in intracerebral hemorrhage rats].
Chlamydophila Infections
An epistatic effect of apaf-1 and caspase-9 on chlamydial infection.
Cholangiocarcinoma
A Ligand for Peroxisome Proliferator-Activated Receptor gamma Inhibits Human Cholangiocarcinoma Cell Growth: Potential Molecular Targeting Strategy for Cholangioma.
Effect of (103)Pd radioactive stent on caspase-9, cholangiocarcinoma cell growth and its radiosensitivity.
Cholestasis, Intrahepatic
Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant rat models.
Chondrosarcoma
BL-038, a Benzofuran Derivative, Induces Cell Apoptosis in Human Chondrosarcoma Cells through Reactive Oxygen Species/Mitochondrial Dysfunction and the Caspases Dependent Pathway.
FPTB, a novel CA-4 derivative, induces cell apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways.
Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo.
Chordoma
Mapping of candidate region for chordoma development to 1p36.13 by LOH analysis.
Choriocarcinoma
Long Noncoding RNA LINC00261 Suppresses Cell Proliferation and Invasion and Promotes Cell Apoptosis in Human Choriocarcinoma.
Methotrexate induces apoptosis of human choriocarcinoma cell line JAR via a mitochondrial pathway.
Chronic Periodontitis
Porphyromonas gingivalis Differentially Modulates Apoptosome Apoptotic Peptidase Activating Factor 1 in Epithelial Cells and Fibroblasts.
Clubfoot
Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot).
Colitis
Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis.
Neutrophil apoptosis is delayed in an equine model of colitis: Implications for the development of SIRS.
Colitis, Ulcerative
Imbalance of Controlled Death in Peripheral Blood Lymphocytes in Crohn's Disease and Ulcerative Colitis.
Colonic Neoplasms
A ginger derivative, zingerone-a phenolic compound-induces ROS-mediated apoptosis in colon cancer cells (HCT-116).
An active molecule from Pulsatilla chinensis, Pulsatilla saponin A, induces apoptosis and inhibits tumor growth of human colon cancer cells without or with 5-FU.
Apoptotic block in colon cancer cells may be rectified by lentivirus mediated overexpression of caspase-9.
Apoptotic Effect of Saccharomyces cerevisiae on Human Colon Cancer SW480 Cells by Regulation of Akt/NF-?B Signaling Pathway.
Attacking the mitochondria of colorectal carcinoma by novel 2-cyanoacrylamides linked to ethyl 1,3-diphenylpyrazole-4-carboxylates moiety as a new trend for chemotherapy.
Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line.
Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors.
Cardamonin Sensitizes Tumor Cells to TRAIL Through ROS- and CHOP-Mediated Upregulation of Death Receptors and Downregulation of Survival Proteins.
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
Chitosan-coated Zn-metal-organic framework nanocomposites for effective targeted delivery of LNA-antisense miR-224 to colon tumor: in vitro studies.
Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis.
Defining characteristics of Types I and II apoptotic cells in response to TRAIL.
HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.
Inducing apoptosis of human colon cancer cells by an IGF-I D domain analogue peptide.
Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway.
Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest.
Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice.
Pinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells.
Regulation of caspase expression and apoptosis by adenomatous polyposis coli.
The ?6-integrin-ERK/MAP kinase pathway contributes to chemo resistance in colon cancer.
The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand.
The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway.
Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization.
Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells.
[Down-regulation of sphingosine kinase 1 (SphK1) enhances the chemosensitivity to cisplatin in human colon cancer RKO cells].
Colorectal Neoplasms
Antibody against N-terminal domain of phospholipid scramblase 1 induces apoptosis in colorectal cancer cells through the intrinsic apoptotic pathway.
Apoptotic block in colon cancer cells may be rectified by lentivirus mediated overexpression of caspase-9.
Association of CASP9, CASP10 gene polymorphisms and tea drinking with colorectal cancer risk in the Han Chinese population.
Attacking the mitochondria of colorectal carcinoma by novel 2-cyanoacrylamides linked to ethyl 1,3-diphenylpyrazole-4-carboxylates moiety as a new trend for chemotherapy.
Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects.
Diallyl trisulfide induces apoptosis in human primary colorectal cancer cells.
Down regulation of caspase-9 is a frequent event in patients with stage II colorectal cancer and correlates with poor clinical outcome.
Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells.
Knockdown of MiR-20a Enhances Sensitivity of Colorectal Cancer Cells to Cisplatin by Increasing ASK1 Expression.
Modulation of gene expression in CD4+ T lymphocytes following in vitro HIV infection: a comparison between human and chimpanzee.
Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9.
Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.
Polymorphisms of Caspase 8 and Caspase 9 gene and colorectal cancer susceptibility and prognosis.
Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L).
Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression.
Targeting colorectal cancer stem cells with inducible caspase-9.
Congenital Abnormalities
Calcium Alleviates Fluoride-Induced Bone Damage by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction.
Gamma-irradiation-induced testicular oxidative stress and apoptosis: Mitigation by l-carnitine.
Coronary Disease
[Effect of Gualou Xiebai Banxia decoction combined with Xuefu Zhuyu decoction on myocardial apoptosis and relevant protein expressions in miniature swine phlegm and blood stasis type coronary heart disease model].
Coronavirus Infections
Equine coronavirus induces apoptosis in cultured cells.
Porcine hemagglutinating encephalomyelitis virus induces apoptosis in a porcine kidney cell line via caspase-dependent pathways.
COVID-19
COVID-19 and male reproductive function: a prospective, longitudinal cohort study.
Crohn Disease
Imbalance of Controlled Death in Peripheral Blood Lymphocytes in Crohn's Disease and Ulcerative Colitis.
Polymorphisms in apoptosis genes predict response to infliximab therapy in luminal and fistulizing Crohn's disease.
Cystadenocarcinoma, Serous
A Network Pharmacology-Based Analysis of Multi-Target, Multi-Pathway, Multi-Compound Treatment for Ovarian Serous Cystadenocarcinoma.
Cysts
Chronic effects of maternal tobacco-smoke exposure and/or ?-lipoic acid treatment on reproductive parameters in female rat offspring.
Effect of calcium hydroxide as intracanal medicament on the expression of caspase-9 located within the radicular cyst epithelium.
Dehydration
Effects of long-term dehydration on oxidative stress, apoptotic markers and neuropeptides in the gastric mucosa of the dromedary camel.
Immunohistochemical expression of Bcl-2, p53 and caspase-9 in hypothalamus magnocellular centers of nNOS knockout mice following water deprivation.
Dementia
Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.
Diabetic Nephropathies
Immunohistochemical Aspects of Cell Death in Diabetic Nephropathy.
Diabetic Retinopathy
Mitochondria- and caspase-dependent cell death pathway involved in neuronal degeneration in diabetic retinopathy.
Role of the intrinsic apoptotic pathway in cataractogenesis in type 2 diabetic patients.
Dwarfism
The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation.
e2 ubiquitin-conjugating enzyme deficiency
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
Encephalitis, Japanese
Rana catesbeiana ribonuclease inhibits Japanese encephalitis virus (JEV) replication and enhances apoptosis of JEV-infected BHK-21 cells.
Encephalocele
Apoptosis, Expression of PAX3 and P53, and Caspase Signal in Fetuses with Neural Tube Defects.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Effects of 1alpha, 25-dihydroxyvitamin D3 on programmed cell death of Ishikawa endometrial cancer cells through ezrin phosphorylation.
Effects of Novel Alkyl Pyridine Platinum Complexes on Apoptosis in Ishikawa Endometrial Cancer Cells.
Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells.
MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway.
Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro.
The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells.
Endometriosis
Mullerian inhibiting substance suppresses proliferation and induces apoptosis and autophagy in endometriosis cells in vitro.
Endotoxemia
Long-lasting effect of infant rats endotoxemia on heat shock protein 60 in the pancreatic acinar cells: involvement of toll-like receptor 4.
Epilepsy
Bcl-2 and Caspase-9 serum levels in children and adolescents with idiopathic epilepsy and active seizures.
Down-Regulation of Mir-145 Improves Learning and Memory Abilities in Epileptic Rats by Regulating Hippocampal Neuron Apoptosis.
Epistaxis
Caspase 3 activation in nasal capillary in patients with epistaxis.
Epstein-Barr Virus Infections
Proteomics Analysis of Gastric Epithelial AGS Cells Infected with Epstein-Barr Virus.
Escherichia coli Infections
Hepatic histopathology and apoptosis in diet-induced-obese mice under Escherichia coli pneumonia.
Esophageal Neoplasms
[Expressions and clinical significances of iASPP and caspase-9 in esophageal cancer].
[THAP11 mediates the proliferation and apoptosis of esophageal cancer cells via inhibiting ubiquitination of p53].
Esophageal Squamous Cell Carcinoma
The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation.
Fatty Liver
Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK.
Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study.
Fetal Growth Retardation
Serum Bcl-2, caspase-9 and soluble FasL levels as perinatal markers in late preterm pregnancies with intrauterine growth restriction.
Fibrosarcoma
Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression.
The antiproliferative function of violacein-like purple violet pigment (PVP) from an Antarctic Janthinobacterium sp. Ant5-2 in UV-induced 2237 fibrosarcoma.
Follicular Cyst
Chronic effects of maternal tobacco-smoke exposure and/or ?-lipoic acid treatment on reproductive parameters in female rat offspring.
Food Hypersensitivity
[Soluble apoptosis markers in obese patients with food intolerance].
Fuchs' Endothelial Dystrophy
Unfolded protein response in fuchs endothelial corneal dystrophy: a unifying pathogenic pathway?
Gallbladder Neoplasms
Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells.
Gastritis
Dysregulated Expression of Apoptosis-Associated Genes and MicroRNAs and Their Involvement in Gastric Carcinogenesis.
Gastrointestinal Neoplasms
Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.
Glaucoma
Activation of caspase 9 in a rat model of experimental glaucoma.
Glioblastoma
Activation of caspase-9 with irradiation inhibits invasion and angiogenesis in SNB19 human glioma cells.
Glioblastoma cell death induced by asiatic acid.
High expression of XIAP and Bcl-2 may inhibit programmed cell death in glioblastomas.
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas.
Immunohistochemical localization of caspase-3, caspase-9 and Bax in U87 glioblastoma xenografts.
Investigation of U-251 cell death triggered by flavonoid luteolin: towards a better understanding on its anticancer property against glioblastomas.
Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells.
MEG-3-mediated Wnt/?-catenin signaling pathway controls the inhibition of tunicamycin-mediated viability in glioblastoma.
N-(4-Hydroxyphenyl)retinamide induced differentiation with repression of telomerase and cell cycle to increase interferon-gamma sensitivity for apoptosis in human glioblastoma cells.
Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim.
Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.
REIC/Dkk-3 induces cell death in human malignant glioma.
The growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82 is inhibited by the resveratrol oligomers hopeaphenol and r2-viniferin.
Glioma
?-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein.
Activation of caspase-9 with irradiation inhibits invasion and angiogenesis in SNB19 human glioma cells.
Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM.
Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation.
CASP9 Germline Mutation in a Family with Multiple Brain Tumors.
Caspase-9 pathway activation by inhibiting endogenous fibroblast growth factor signaling in human glioma cells.
Caspase-9 transduction overrides the resistance mechanism against p53-mediated apoptosis in U-87MG glioma cells.
Caspase-9 transduction overrides the resistance mechanism against p53-mediated apoptosis in U87MG glioma cells.
Co-transduction of Apaf-1 and caspase-9 augments etoposide-induced apoptosis in U-373MG glioma cells.
Co-transduction of Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas.
Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme.
Conditioned media from human adipose tissue-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells efficiently induced the apoptosis and differentiation in human glioma cell lines in vitro.
Cord blood stem cell-mediated induction of apoptosis in glioma downregulates X-linked inhibitor of apoptosis protein (XIAP).
Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt.
Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway.
Effects of microRNA-195 on the Prognosis of Glioma Patients and the Proliferation and Apoptosis of Human Glioma Cells.
Evodiamine Prevents Glioma Growth, Induces Glioblastoma Cell Apoptosis and Cell Cycle Arrest through JNK Activation.
Extracts of marine sponge Polymastia janeirensis induce oxidative cell death through a caspase-9 apoptotic pathway in human U138MG glioma cell line.
Gene therapy using an adenovirus vector for apoptosis-related genes is a highly effective therapeutic modality for killing glioma cells.
Human malignant glioma therapy using anti-alpha(v)beta3 integrin agents.
Induction of apoptosis in mammalian cells by cadmium and zinc.
Induction of apoptosis in resistant glioma cells by synthetic caspase-activation.
Inhibition of ?-opioid receptors induces brain glioma cell apoptosis through the mitochondrial and protein kinase C pathways.
Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma.
Knockdown of ADAMDEC1 inhibits the progression of glioma in vitro.
Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression.
Mechanism of As2O3 induces apoptosis of glioma U87 cells.
MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway.
MiR-135a and MRP1 play pivotal roles in the selective lethality of phenethyl isothiocyanate to malignant glioma cells.
Oroxyloside inhibits human glioma progression by suppressing proliferation, metastasis and inducing apoptosis related pathways.
Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells.
Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3.
Role of Caspase-9 Gene Ex5+32 G>A (rs1052576) Variant in Susceptibility to Primary Brain Tumors.
Synthesis and in vitro evaluation of 4-substituted furano[3,2-c] tetrahydroquinolines as potential anti-cancer agents.
T11TS repress gliomagenic apoptosis of bone marrow hematopoietic stem cells.
Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice.
[Evodiamine Promotes Apoptosis of Glioma SHG-44 Cells and Its Mechanism].
Gout
Enhanced p62 Is Responsible for Mitochondrial Pathway-Dependent Apoptosis and Interleukin-1? Production at the Early Phase by Monosodium Urate Crystals in Murine Macrophage.
Graft vs Host Disease
Clonal Dynamics In Vivo of Virus Integration Sites of T Cells Expressing a Safety Switch.
Serial Activation of the Inducible Caspase 9 Safety Switch After Human Stem Cell Transplantation.
Gram-Negative Bacterial Infections
Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster.
Head and Neck Neoplasms
GSTP1 c.313A>G, XPD c.934G>A, XPF c.2505T>C and CASP9 c.-1339A>G Polymorphisms and Severity of Vomiting in Head and Neck Cancer Patients treated with Cisplatin Chemoradiation.
Hearing Loss
Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss.
Heart Arrest
Therapeutic Hypothermia Enhances Cold-Inducible RNA-Binding Protein Expression and Inhibits Mitochondrial Apoptosis in a Rat Model of Cardiac Arrest.
Hepatic Encephalopathy
Ameliorative effect of Magnesium Isoglycyrrhizinate on hepatic encephalopathy by Epirubicin.
Hepatitis B
Hepatitis B vaccine induces apoptotic death in Hepa1-6 cells.
Intrahepatic activation of caspases in human fulminant hepatic failure.
Hepatitis C
Inhibition of hepatitis C virus core protein expression in immortalized human hepatocytes induces cytochrome c-independent increase in Apaf-1 and caspase-9 activation for cell death.
Herpes Simplex
Caspase 9 is essential for herpes simplex virus type 2-induced apoptosis in T cells.
Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells.
Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons.
Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy.
Prevention of hepatitis C virus infection by adoptive allogeneic immunotherapy using suicide gene-modified lymphocytes: an in vitro proof-of-concept.
The bovine viral diarrhea virus (BVDV) NS3 protein, when expressed alone in mammalian cells, induces apoptosis which correlates with caspase-8 and caspase-9 activation.
The equine arteritis virus induces apoptosis via caspase-8 and mitochondria-dependent caspase-9 activation.
Histiocytic Sarcoma
The growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82 is inhibited by the resveratrol oligomers hopeaphenol and r2-viniferin.
Huntington Disease
Cytochrome C and caspase-9 expression in Huntington's disease.
Hyperalgesia
Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain.
Hyperglycemia
Impact of hyperglycemia on neuronal apoptosis after subarachnoid hemorrhage in rodent brain: An experimental research.
Hyperhomocysteinemia
Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels.
Hyperlipidemias
[Effect of electroacupuncture on caspase-9 expression in hippocampus and neuroethology in hyperlipemia rats with concurrent cerebral ischemia]
Hypertension
Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation.
Hyperthyroidism
Severe hyperthyroidism induces mitochondria-mediated apoptosis in rat liver.
Hypoxia, Brain
ATP and cytochrome c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets.
Effect of hypoxia on the expression of procaspase-9 and procaspase-3 in neuronal nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets.
Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets.
Hypoxia-induced Bax and Bcl-2 protein expression, caspase-9 activation, DNA fragmentation, and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets: the role of nitric oxide.
Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx.
Mechanism of tyrosine phosphorylation of procaspase-9 and Apaf-1 in cytosolic fractions of the cerebral cortex of newborn piglets during hypoxia.
Infarction, Middle Cerebral Artery
Licorice Pretreatment Protects Against Brain Damage Induced by Middle Cerebral Artery Occlusion in Mice.
Permanent cerebral ischemia induces sustained procaspase 9L increase not controlled by Bcl-2.
Pien-Tze-Huang protects cerebral ischemic injury by inhibiting neuronal apoptosis in acute ischemic stroke rats.
Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways.
Potentiation of Akt and suppression of caspase-9 activations by electroacupuncture after transient middle cerebral artery occlusion in rats.
Infections
5-aza-2'-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells.
Ad-PUMA sensitizes ovarian cancer cells to chemotherapeutic agents.
Adenovirus type 5 E1A gene therapy for ovarian clear cell carcinoma: a potential treatment strategy.
Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein.
An epistatic effect of apaf-1 and caspase-9 on chlamydial infection.
Anaplasma phagocytophilum delays spontaneous human neutrophil apoptosis by modulation of multiple apoptotic pathways.
Apoptosis-related gene expression in hamster opisthorchiasis post praziquantel treatment.
Apoptotic caspases suppress Mycobacterium bovis-induced IFN-? production in murine macrophage.
Autophagy Delays Apoptotic Cell Death Induced by Siniperca chuatsi Rhabdovirus in Epithelioma Papulosum Cyprinid Cells.
Bak and Bax function to limit adenovirus replication through apoptosis induction.
Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores.
Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of beta1-integrin, ERK, and NF-kappaB.
Both PI3K- and mTOR-signaling pathways take part in CVB3-induced apoptosis of Hela cells.
Bovine herpes virus type 1 induces apoptosis through Fas-dependent and mitochondria-controlled manner in Madin-Darby bovine kidney cells.
Cancer gene therapy using a survivin mutant adenovirus.
Caspase-9 pathway activation by inhibiting endogenous fibroblast growth factor signaling in human glioma cells.
Conversion of trichosanthin-induced CD95 (Fas) type I into type II apoptotic signaling during Herpes simplex virus infection.
Coxsackievirus A16 infection induces neural cell and non-neural cell apoptosis in vitro.
Crimean-Congo haemorrhagic fever replication interplays with regulation mechanisms of apoptosis.
Cytosolic phospholipase A2 participates with TNF-alpha in the induction of apoptosis of human macrophages infected with Mycobacterium tuberculosis H37Ra.
Edwardsiella piscicida type III protein EseJ suppresses apoptosis through down regulating type 1 fimbriae, which stimulate the cleavage of caspase-8.
Effects of dietary monocalcium phosphate supplementation on the anti-oxidative capacity, anti-bacteria function in immune organs of obscure puffer (Takifugu obscurus) after infection with Aeromonas hydrophila.
Effects of the PI3K/Akt signaling pathway on the apoptosis of early host cells infected with Eimeria tenella.
Enterotoxigenic Escherichia coli infection promotes apoptosis in piglets.
Equine arteritis virus induced cell death is associated with activation of the intrinsic apoptotic signalling pathway.
Fas/FasL pathway participates in resolution of mucosal inflammatory response early during HSV-2 infection.
Genetic mechanisms underlying the pathogenicity of cold-stressed Salmonella enterica serovar typhimurium in cultured intestinal epithelial cells.
Hepatic histopathology and apoptosis in diet-induced-obese mice under Escherichia coli pneumonia.
HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells.
Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable.
Identification of Chlamydia pneumoniae candidate genes that interact with human apoptotic factor caspase-9.
Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection.
Implication of caspases during maedi-visna virus-induced apoptosis.
In vitro infection of bovine monocytes with Mycoplasma bovis delays apoptosis and suppresses production of gamma interferon and tumor necrosis factor alpha but not interleukin-10.
Induction of apoptosis in SSN-1cells by Snakehead Fish Vesiculovirus (SHVV) via Matrix protein dependent intrinsic pathway.
Induction of apoptosis limits cytomegalovirus cross-species infection.
Intrinsic apoptosis and cytokine induction regulated in human tonsillar epithelial cells infected with enterovirus A71.
Intrinsic apoptosis and proinflammatory cytokines regulated in human astrocytes infected with enterovirus 71.
Involvement of caspase activation through release of cytochrome c from mitochondria in apoptotic cell death of macrophages infected with Actinobacillus actinomycetemcomitans.
Involvement of caspase-9 in the inhibition of necrosis of RAW 264 cells infected with Mycobacterium tuberculosis.
Involvement of the PI3K and ERK signaling pathways in largemouth bass virus-induced apoptosis and viral replication.
Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner.
Life as a Vector of Dengue Virus: The Antioxidant Strategy of Mosquito Cells to Survive Viral Infection.
Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276.
Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis.
Modulation of apoptosis by caprine herpesvirus 1 infection in a neuronal cell line.
Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line.
Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells.
Overexpression of interferon-gamma-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the phosphatidylinositol 3-kinase/Akt pathway and inhibition of viral replication.
Parents of ataxia-telangiectasia patients display a distinct cellular immune phenotype mimicking ATM mutated patients.
Phosphoprotein Gene Contributes to the Enhanced Apoptosis Induced by Wild-Type Rabies Virus GD-SH-01 In Vitro.
Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71.
Porcine deltacoronavirus induces caspase-dependent apoptosis through activation of the cytochrome c-mediated intrinsic mitochondrial pathway.
Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation.
Porcine reproductive and respiratory syndrome virus induces apoptosis through a mitochondria-mediated pathway.
Porphyromonas gingivalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells.
Protection against CD95-induced apoptosis by chlamydial infection at a mitochondrial step.
Proteolysis of Pseudomonas exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying in vitro ADP-ribosylating and apoptotic effects.
Relationship between Eimeria tenella development and host cell apoptosis in chickens.
Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors.
Role of the mitochondrial signaling pathway in murine coronavirus-induced oligodendrocyte apoptosis.
Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats.
Streptococcus pyogenes serotype-dependent and independent changes in infected HEp-2 epithelial cells.
The African swine fever virus dynein-binding protein p54 induces infected cell apoptosis.
The Culicoides sonorensis inhibitor of apoptosis 1 protein protects mammalian cells from apoptosis induced by infection with African horse sickness virus and bluetongue virus.
The HIV-1-Specific Protein Casp8p41 Induces Death of Infected Cells through Bax/Bak.
The JAK/STAT3 signaling pathway mediates inhibition of host cell apoptosis by Chlamydia psittaci infection.
The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection.
The major apoptotic pathway activated and suppressed by poliovirus.
The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells.
Transmissible gastroenteritis virus infection induces apoptosis through FasL- and mitochondria-mediated pathways.
Vesicular stomatitis viruses expressing wild-type or mutant M proteins activate apoptosis through distinct pathways.
[Porcine deltacoronavirus induces mitochondrial apoptosis in ST cells].
Infertility, Male
The Role of Protamine 2 Gene Expression and Caspase 9 Activity in Male Infertility.
Inflammatory Bowel Diseases
Association of caspase-9 and RUNX3 with inflammatory bowel disease.
Influenza, Human
Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway.
Influenza A Virus and Influenza B Virus Can Induce Apoptosis via Intrinsic or Extrinsic Pathways and Also via NF-?B in a Time and Dose Dependent Manner.
Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276.
[Antagonism of baicalin on cell cyclical distribution and cell apoptosis in A549 cells infected with influenza A (H1N1) virus].
Insulinoma
Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction of JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio.
Intervertebral Disc Degeneration
Caspase 9 gene polymorphism and susceptibility to lumbar disc disease in the Han population in northern China.
Paeoniflorin inhibits nucleus pulposus cell apoptosis by regulating the expression of Bcl-2 family proteins and caspase-9 in a rabbit model of intervertebral disc degeneration.
Role of the mitochondrial pathway in serum deprivation-induced apoptosis of rat endplate cells.
[Caspase-9 (-Ex5+32 G/A) gene polymorphism is associated with caspase-9 expression in degenerative nucleus pulposus of lumbar intervertebral disc].
Intervertebral Disc Displacement
Caspase 9 gene polymorphism and susceptibility to lumbar disc disease in the Han population in northern China.
Evaluation of the association between biochemical and immunohistochemical score of caspase-9 and TNF?, and the grading of lumbar disc herniation.
Iron Overload
Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload.
Ischemic Attack, Transient
Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia.
The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia.
Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus.
Ischemic Stroke
Association Between a Polymorphism in CASP3 and CASP9 Genes and Ischemic Stroke.
Pien-Tze-Huang protects cerebral ischemic injury by inhibiting neuronal apoptosis in acute ischemic stroke rats.
Keloid
A comparison expression analysis of CXCR4, CXCL9 and Caspase-9 in dermal vascular endothelial cells between keloids and normal skin on chemotaxis and apoptosis.
Activated caspase expression and apoptosis increase in keloids: cytochrome c release and caspase-9 activation during the apoptosis of keloid fibroblast lines.
Ketosis
Oxidative stress, NF-?B signaling, NLRP3 inflammasome, and caspase apoptotic pathways are activated in mammary gland of ketotic Holstein cows.
Laryngeal Neoplasms
Inhibition of caspase-9 by oridonin, a diterpenoid isolated from Rabdosia rubescens, augments apoptosis in human laryngeal cancer cells.
Leiomyoma
Gyejibongnyeong-Hwan (Gui Zhi Fu Ling Wan) Ameliorates Human Uterine Myomas via Apoptosis.
[Expression of caspase 9 and p53 in uterine leiomyosarcomas].
Leiomyosarcoma
[Expression of caspase 9 and p53 in uterine leiomyosarcomas].
Leukemia
A112, a tamibarotene dimethylaminoethyl ester, may inhibit human leukemia cell growth more potently than tamibarotene.
Ampelopsin Inhibits Cell Proliferation and Induces Apoptosis in HL60 and K562 Leukemia Cells by Downregulating AKT and NF-?B Signaling Pathways.
Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase.
Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation.
Apoptotic Effect of Galbanic Acid via Activation of Caspases and Inhibition of Mcl-1 in H460 Non-Small Lung Carcinoma Cells.
Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1-Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells.
Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.
Breaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells.
Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells.
Caspase-9 is the upstream caspase activated by 8-methoxypsoralen and ultraviolet-A radiation treatment of Jurkat T leukemia cells and normal T lymphocytes.
Compound K induced apoptosis via endoplasmic reticulum Ca2+ release through ryanodine receptor in human lung cancer cells.
Dietary docosahexaenoic acid decreased lipid accumulation via inducing adipocytes apoptosis of grass carp, Ctenopharygodon idella.
Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP).
Effects of AG490 and S3I-201 on regulation of the JAK/STAT3 signaling pathway in relation to angiogenesis in TRAIL-resistant prostate cancer cells in vitro.
Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines.
Inducing cell proliferative prevention in human acute promyelocytic leukemia by miR-182 inhibition through modulation of CASP9 expression.
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.
Inhibition of nitric-oxide-mediated apoptosis in Jurkat leukemia cells despite cytochrome c release.
Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells.
Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells.
Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance.
Methylene chloride fraction of Scutellaria barbata induces apoptosis in human U937 leukemia cells via the mitochondrial signaling pathway.
Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: activation of caspase-8 and caspase-9 is involved in activation of caspase-3.
Monoterpenes as drug shuttles: cytotoxic (6-aminomethylnicotinate)dichloridoplatinum(II) complexes with potential to overcome cisplatin resistance.
Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells.
Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis.
Pyrrolidine dithiocarbamate inhibition of luteolin-induced apoptosis through up-regulated phosphorylation of Akt and caspase-9 in human leukemia HL-60 cells.
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) exert their anti-proliferative activity by interfering with Akt-mTOR signaling and bax:bcl-2 ratio modulation in cells from chronic myeloid leukemic patients.
Radiation-induced apoptosis is independent of caspase-8 but dependent on cytochrome c and the caspase-9 cascade in human leukemia HL60 cells.
Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces apoptosis via Fas-mediated pathway in HL-60 human leukemia cells.
Resveratrol enhances anticancer effects of paclitaxel in HepG2 human liver cancer cells.
Tanshinone IIA inhibits human gastric carcinoma AGS cell growth by decreasing BiP, TCTP, Mcl?1 and Bcl?xL and increasing Bax and CHOP protein expression.
The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction.
The non-apoptotic role of caspase-9 promotes differentiation in leukemic cells.
The possibility of simvastatin as a chemotherapeutic agent for all-trans retinoic acid-resistant promyelocytic leukemia.
Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma.
[BMMSC from blastic phase CML down-regulate leukemia cell apoptosis].
[Effects of SODD and survivin on leukemia cell apoptosis induced by chemotherapeutic drugs]
[Role of High Mobility Group Box 1 in Adriamycin-induced Apoptosis in Leukemia K562 Cells.]
[The mechanism for SHIP gene to induce the apoptosis of human leukemia cell line K562.]
Leukemia, B-Cell
Apoptosis in meningoencephalitis of Angiostrongylus cantonensis-infected mice.
Dietary docosahexaenoic acid decreased lipid accumulation via inducing adipocytes apoptosis of grass carp, Ctenopharygodon idella.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
3,5-dibenzyloxy-4'-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells.
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) exert their anti-proliferative activity by interfering with Akt-mTOR signaling and bax:bcl-2 ratio modulation in cells from chronic myeloid leukemic patients.
Leukemia, Myeloid
The Effect of Bornyl cis-4-Hydroxycinnamate on Melanoma Cell Apoptosis Is Associated with Mitochondrial Dysfunction and Endoplasmic Reticulum Stress.
[Apoptosis of myeloid leukemia cell line HL60 induced by Bortezomib, a proteasome inhibitor]
Leukemia, Myeloid, Acute
A CD33 Antigen-Targeted AAV6 Vector Expressing an Inducible Caspase-9 Suicide Gene Is Therapeutic in a Xenotransplantation Model of Acute Myeloid Leukemia.
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.
Leukemia, Promyelocytic, Acute
Inducing cell proliferative prevention in human acute promyelocytic leukemia by miR-182 inhibition through modulation of CASP9 expression.
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.
Liver Diseases
Carbon monoxide blocks oxidative stress-induced hepatocyte apoptosis via inhibition of the p54 JNK isoform.
Liver Neoplasms
Demethylation of miR-34a upregulates expression of membrane palmitoylated proteins and promotes the apoptosis of liver cancer cells.
Effects of matrine in combination with cisplatin on liver cancer.
Effects of melanoma differentiation associated gene-7 (MDA-7/IL-24) on apoptosis of liver cancer cells via regulating the expression of B-cell lymphoma-2.
Ellagic acid normalizes mitochondrial outer membrane permeabilization and attenuates inflammation-mediated cell proliferation in experimental liver cancer.
Pitavastatin suppressed liver cancer cells in vitro and in vivo.
Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells.
Silencing of WWP2 inhibits adhesion, invasion, and migration in liver cancer cells.
The bioactive ingredients in Actinidia chinensis Planch. Inhibit liver cancer by inducing apoptosis.
Lung Injury
Restoring microRNA-499-5p Protects Sepsis-Induced Lung Injury Mice Via Targeting Sox6.
[Protective effects of dexmedetomidine against pulmonary ischemia-reperfusion injury during cardiopulmonary bypass in rats].
Lung Neoplasms
5-aza-2'-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells.
?-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells.
A facile approach for fabricating CD44-targeted delivery of hyaluronic acid-functionalized PCL nanoparticles in urethane-induced lung cancer: Bcl-2, MMP-9, caspase-9, and BAX as potential markers.
A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer.
Activation of mitochondrial pathway is crucial for tumor selective induction of apoptosis by LAQ824.
Altered expression profile of apoptosis-related molecules correlated with clinicopathological factors in non-small-cell lung cancer.
Alternative Splicing of Caspase 9 Is Modulated by the Phosphoinositide 3-Kinase/Akt Pathway via Phosphorylation of SRp30a.
Antitumor activity of 4-O-(2?-O-acetyl-6?-O-p-coumaroyl-?-D-glucopyranosyl)-p-coumaric acid against lung cancers via mitochondrial-mediated apoptosis.
ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features.
Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors.
Caspase 9 promoter polymorphisms and risk of primary lung cancer.
Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung cancer cells via p38 MAPK, ERK, and Akt signaling pathways.
COL11A1 Was Involved in Cell Proliferation, Apoptosis and Migration in Non-Small Cell Lung Cancer Cells.
Correction to: a facile approach for fabricating CD44-targeted delivery of hyaluronic acid-functionalized PCL nanoparticles in urethane-induced lung cancer: Bcl-2, MMP-9, caspase-9, and BAX as potential markers.
Cytotoxic effects of Pseudocerastes persicus venom and its HPLC fractions on lung cancer cells.
Defective caspase-3 relocalization in non-small cell lung carcinoma.
Effects and mechanism of downregulation of survivin expression by RNA interference on proliferation and apoptosis of lung cancer cells.
Effects of Selenium Nanoparticles Combined With Radiotherapy on Lung Cancer Cells.
Expression and prognostic significance of osteopontin and caspase-3 in hepatocellular carcinoma patients after curative resection.
Extract of Calvatia gigantea inhibits proliferation of A549 human lung cancer cells.
hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing.
Investigation of Caspase 9 Gene Polymorphism in Patients With Non-small Cell Lung Cancer.
MicroRNA-145 replacement effect on growth and migration inhibition in lung cancer cell line.
miR-1269 promotes cell survival and proliferation by targeting tp53 and caspase-9 in lung cancer.
Osthole extracted from a citrus fruit that affects apoptosis on A549 cell line by histone deacetylasese inhibition (HDACs).
Overexpression of smac promotes Cisplatin-induced apoptosis by activating caspase-3 and caspase-9 in lung cancer a549 cells.
Plumbagin engenders apoptosis in lung cancer cells via caspase-9 activation and targeting mitochondrial-mediated ROS induction.
Polymorphisms in the caspase genes and the risk of lung cancer.
Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance.
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation.
RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo.
Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small cell lung cancer cells: a small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3 activation.
SRSF1 Regulates the Alternative Splicing of Caspase 9 Via A Novel Intronic Splicing Enhancer Affecting the Chemotherapeutic Sensitivity of Non-Small Cell Lung Cancer Cells.
Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells.
Sulforaphane-induced apoptosis in Xuanwei lung adenocarcinoma cell line XWLC-05.
Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer.
Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model.
The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand.
The tumor suppressor gene RBM5 inhibits lung adenocarcinoma cell growth and induces apoptosis.
TIPE2 Inhibits Lung Cancer Growth Attributing to Promotion of Apoptosis by Regulating Some Apoptotic Molecules Expression.
Yap-Hippo promotes A549 lung cancer cell death via modulating MIEF1-related mitochondrial stress and activating JNK pathway.
[A study on the expression of CASP9 gene and its polymorphism distribution in non-small cell lung cancer]
Lupus Erythematosus, Systemic
Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic lupus erythematosus.
Lymphatic Metastasis
EMP1 regulates caspase-9 and VEGFC expression and suppresses prostate cancer cell proliferation and invasion.
EMP1, a member of a new family of antiproliferative genes in breast carcinoma.
[A study on the expression of CASP9 gene and its polymorphism distribution in non-small cell lung cancer]
[Expressions and clinical significances of iASPP and caspase-9 in esophageal cancer].
Lymphoma
A B-Cell Superantigen Induces the Apoptosis of Murine and Human Malignant B Cells.
A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis.
A Litopenaeus vannamei Hemocyanin-Derived Antimicrobial Peptide (Peptide B11) Attenuates Cancer Cells' Proliferation.
Anticancer Effect of Ursodeoxycholic Acid in Human Oral Squamous Carcinoma HSC-3 Cells through the Caspases.
Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.
Bone morphogenetic protein 9 facilitates osteocarcinoma cell apoptosis and inhibits in vivo tumor growth.
Characterization of antiapoptotic microRNAs in primary Sjögren's syndrome.
Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma.
Dimethyl sulfoxide activates tumor necrosis factor?-p53 mediated apoptosis and down regulates d-fructose-6-phosphate-2-kinase and lactate dehydrogenase-5 in Dalton's lymphoma in vivo.
Dissecting p53 tumor suppressor functions in vivo.
Furosine Induced Apoptosis by the Regulation of STAT1/STAT2 and UBA7/UBE2L6 Genes in HepG2 Cells.
Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species.
Inert ruthenium half-sandwich complexes with anticancer activity.
Inhibition of caspase 9 and not caspase 8 mediated apoptosis may determine clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas.
Involvement of mitochondrial permeability transition and caspase-9 activation in dimethyl sulfoxide-induced apoptosis of EL-4 lymphoma cells.
Long-term beneficial effect of protease inhibitors on the intrinsic apoptosis of peripheral blood mononuclear cells in HIV-infected patients.
Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells.
Motexafin gadolinium induces mitochondrially-mediated caspase-dependent apoptosis.
Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression.
Protective effects elicited by levosimendan against liver ischemia/reperfusion injury in anesthetized rats.
Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma.
Qilin pills alleviate oligoasthenospermia by inhibiting Bax-caspase-9 apoptosis pathway in the testes of model rats.
Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis.
Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways.
Sialic acids linked to glycoconjugates of Fas regulate the caspase-9-dependent and mitochondria-mediated pathway of Fas-induced apoptosis in Jurkat T cell lymphoma.
Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage.
The cardioprotective effects of diallyl trisulfide on diabetic rats with ex vivo induced ischemia/reperfusion injury.
The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.
The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy.
The Inhibition Effect of the Seaweed Polyphenol, 7-Phloro-Eckol from Ecklonia Cava on Alcohol-Induced Oxidative Stress in HepG2/CYP2E1 Cells.
The Protective Role of Selenium Against AFB1-Induced Liver Apoptosis by Death Receptor Pathway in Broilers.
Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.
Upregulation of phosphatase and tensin homolog is essential for the effect of 4-aminopyridine on A549/CDDP cells.
Lymphoma, B-Cell
9-cis retinoic acid inhibits cumulus cell apoptosis during the maturation of bovine cumulus-oocyte-complexes.
A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis.
A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma.
Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling.
Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells.
Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes mellitus.
Ammonia inhalation impaired immune function and mitochondrial integrity in the broilers bursa of fabricius: Implication of oxidative stress and apoptosis.
An active molecule from Pulsatilla chinensis, Pulsatilla saponin A, induces apoptosis and inhibits tumor growth of human colon cancer cells without or with 5-FU.
Anguilla japonica lectin 1 delivery through adenovirus vector induces apoptotic cancer cell death through interaction with PRMT5.
Anti-Condyloma acuminata mechanism of microRNAs-375 modulates HPV in cervical cancer cells via the UBE3A and IGF-1R pathway.
Anti-Proliferative and Apoptotic Activities of Müllerian Inhibiting Substance Combined with Calcitriol in Ovarian Cancer Cell Lines.
Anticancer effect of inactivated Sendai virus strain Tianjin on human osteosarcoma HOS cells.
Anticancer effects of ?-elemene with hyperthermia in lung cancer cells.
Antitumor and Apoptosis-inducing Effects of Piperine on Human Melanoma Cells.
Antitumor effect of forbesione isolated from Garcinia hanburyi on cholangiocarcinoma in vitro and in vivo.
Apatinib suppresses the Proliferation and Apoptosis of Gastric Cancer Cells via the PI3K/Akt Signaling Pathway.
Apoptosis in temporomandibular joint disc with internal derangement involves mitochondrial-dependent pathways. An in vivo study.
Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells.
Biological activity of Brassica rapa L. polysaccharides on RAW264.7 macrophages and on tumor cells.
Calf Spleen Extractive Injection (CSEI), a small peptides enriched extraction, induces human hepatocellular carcinoma cell apoptosis via ROS/MAPKs dependent mitochondrial pathway.
Characterization and anti-tumor activity of saponin-rich fractions of South Korean sea cucumbers (Apostichopus japonicus).
Characterization of antiapoptotic microRNAs in primary Sjögren's syndrome.
Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing
Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp.
Cicadidae Periostracum, the Cast-Off Skin of Cicada, Protects Dopaminergic Neurons in a Model of Parkinson's Disease.
Cordycepin, a Natural Antineoplastic Agent, Induces Apoptosis of Breast Cancer Cells via Caspase-dependent Pathways.
Cypermethrin Alters the Expression Profile of mRNAs in the Adult Rat Striatum: A Putative Mechanism of Postnatal Pre-exposure Followed by Adulthood Re-exposure-Enhanced Neurodegeneration.
Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells.
Deficiency of dietary pyridoxine disturbed the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella).
Demethylation of miR-34a upregulates expression of membrane palmitoylated proteins and promotes the apoptosis of liver cancer cells.
Development of an alternative zebrafish model for drug-induced intestinal toxicity.
Differential regulation of caspase-9 by ionizing radiation- and UV-induced apoptotic pathways in thymic cells.
Duhuo Jisheng decoction treatment inhibits the sodium nitroprussiate?induced apoptosis of chondrocytes through the mitochondrial?dependent signaling pathway.
Effects of dietary monocalcium phosphate supplementation on the anti-oxidative capacity, anti-bacteria function in immune organs of obscure puffer (Takifugu obscurus) after infection with Aeromonas hydrophila.
Effects of ELL-associated factor 2 on ultraviolet radiation-induced cataract formation in mice.
Epigallocatechin-3-gallate protects against hepatic ischaemia-reperfusion injury by reducing oxidative stress and apoptotic cell death.
Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation.
Fomes fomentarius Ethanol Extract Exerts Inhibition of Cell Growth and Motility Induction of Apoptosis via Targeting AKT in Human Breast Cancer MDA-MB-231 Cells.
Galbanic acid potentiates TRAIL induced apoptosis in resistant non-small cell lung cancer cells via inhibition of MDR1 and activation of caspases and DR5.
Ginkgo biloba Extract EGb761 Attenuates Bleomycin-Induced Experimental Pulmonary Fibrosis in Mice by Regulating the Balance of M1/M2 Macrophages and Nuclear Factor Kappa B (NF-?B)-Mediated Cellular Apoptosis.
Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species.
Hesperetin Promotes Cisplatin-Induced Apoptosis of Gastric Cancer In Vitro and In Vivo by Upregulating PTEN Expression.
Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes.
HSP70/HSP90-Organizing Protein Contributes to Gastric Cancer Progression in an Autocrine Fashion and Predicts Poor Survival in Gastric Cancer.
Huaier aqueous extract induces apoptosis of human fibrosarcoma HT1080 cells through the mitochondrial pathway.
Hyperthermia enhances the sensitivity of pancreatic cancer SW1990 cells to gemcitabine through ROS/JNK signaling.
Ibuprofen Protects from Cypermethrin-Induced Changes in the Striatal Dendritic Length and Spine Density.
Inhibition of caspase 9 and not caspase 8 mediated apoptosis may determine clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas.
Inhibition of Myosin Light-Chain Kinase Enhances the Clearance of Lipopolysaccharide-Induced Lung Inflammation Possibly by Accelerating Neutrophil Apoptosis.
Inhibition of Proliferation in U937 Cells Treated by Blue Light Irradiation and Combined Blue Light Irradiation/Drug.
Inhibition of the intrinsic apoptosis pathway downstream of caspase-9 activation causes chemotherapy resistance in diffuse large B-cell lymphoma.
Inulin Induces Dendritic Cells Apoptosis through the Caspase-Dependent Pathway and Mitochondrial Dysfunction.
Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells.
Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling.
Low temperature exerts protective effects by inhibiting mitochondria-mediated apoptosis pathway following pressure injury to rat muscle.
Luteolin induces apoptosis in vitro through suppressing the MAPK and PI3K signaling pathways in gastric cancer.
Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest.
MicroRNA-181a suppresses norethisterone-promoted tumorigenesis of breast epithelial MCF10A cells through the PGRMC1/EGFR-PI3K/Akt/mTOR signaling pathway.
MiR-145-5p promotes myocardial cell apoptosis in rats with myocardial infarction through PI3K/Akt signaling pathway.
Mitochondrial separation protein inhibitor inhibits cell apoptosis in rat lungs during intermittent hypoxia.
Modulation of the DNA repair system and ATR-p53 mediated apoptosis is relevant for tributyltin-induced genotoxic effects in human hepatoma G2 cells.
Neuroprotective and antioxidant activities of bamboo salt soy sauce against H2O2-induced oxidative stress in rat cortical neurons.
Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway.
Oral treatment with herbal formula B307 alleviates cardiac failure in aging R6/2 mice with Huntington's disease via suppressing oxidative stress, inflammation, and apoptosis.
Oral treatment with the herbal formula B307 alleviates cardiac toxicity in doxorubicin-treated mice via suppressing oxidative stress, inflammation, and apoptosis.
Ozone induces BEL7402 cell apoptosis by increasing reactive oxygen species production and activating JNK.
Palmitic Acid-Induced Podocyte Apoptosis via the Reactive Oxygen Species-Dependent Mitochondrial Pathway.
Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells.
Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio.
Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways.
Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3.
Pro-apoptotic and anti-proliferative effects of corn silk extract on human colon cancer cell lines.
Protective effects elicited by levosimendan against liver ischemia/reperfusion injury in anesthetized rats.
Qilin pills alleviate oligoasthenospermia by inhibiting Bax-caspase-9 apoptosis pathway in the testes of model rats.
Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis.
Role of Exogenous Hsp72 on Liver Dysfunction during Sepsis.
Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer.
Shenfu injection prevents sepsis-induced myocardial injury by inhibiting mitochondrial apoptosis.
Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways.
Shikonin inhibits TNF-?-induced growth and invasion of rat aortic vascular smooth muscle cells.
Silencing of human phosphatidylethanolamine-binding protein 4 enhances rituximab-induced death and chemosensitization in B-cell lymphoma.
Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line.
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells.
Subretinal Fluid Levels of Signal-Transduction Proteins and Apoptosis Molecules in Macula-Off Retinal Detachment Undergoing Scleral Buckle Surgery.
Sulforaphane-induced apoptosis in Xuanwei lung adenocarcinoma cell line XWLC-05.
Synergistic Effect of Forbesione From Garcinia hanburyi in Combination with 5-Fluorouracil on Cholangiocarcinoma
Tau phosphorylation and cochlear apoptosis cause hearing loss in 3×Tg-AD Mouse Model of Alzheimer's Disease.
The cardioprotective effects of diallyl trisulfide on diabetic rats with ex vivo induced ischemia/reperfusion injury.
The Effect of Bornyl cis-4-Hydroxycinnamate on Melanoma Cell Apoptosis Is Associated with Mitochondrial Dysfunction and Endoplasmic Reticulum Stress.
The Inhibition Effect of the Seaweed Polyphenol, 7-Phloro-Eckol from Ecklonia Cava on Alcohol-Induced Oxidative Stress in HepG2/CYP2E1 Cells.
The Protective Role of Selenium Against AFB1-Induced Liver Apoptosis by Death Receptor Pathway in Broilers.
Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro.
Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells.
Trace Mineral Overload Induced Hepatic Oxidative Damage and Apoptosis in Pigs with Long-Term High-Level Dietary Mineral Exposure.
Uncovering the Anticancer Mechanism of Compound Sophorae Decoction against Ulcerative Colitis-Related Colorectal Cancer in Mice.
Upregulation of let-7f-5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro-apoptotic proteins.
Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma.
[Celastrol inhibits growth and increases apoptosis of human lung cancer A549 cells].
[Chronic venous disease increases placental villous angiogenesis and lymphangiogenesis and villous cell apoptosis].
Lymphoma, Follicular
Feedback regulation of mitochondria by caspase-9 in the B cell receptor-mediated apoptosis.
Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma.
The involvement of mitochondria and the caspase-9 activation pathway in rituximab-induced apoptosis in FL cells.
The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP.
Lymphoma, Large B-Cell, Diffuse
Inhibition of the intrinsic apoptosis pathway downstream of caspase-9 activation causes chemotherapy resistance in diffuse large B-cell lymphoma.
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells.
Lymphoma, Mantle-Cell
The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.
Lymphoma, Non-Hodgkin
Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma.
Lymphoma, T-Cell
MicroRNA-based recombinant AAV vector assembly improves efficiency of suicide gene transfer in a murine model of lymphoma.
Sialic acids linked to glycoconjugates of Fas regulate the caspase-9-dependent and mitochondria-mediated pathway of Fas-induced apoptosis in Jurkat T cell lymphoma.
Malaria
Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis.
Malnutrition
Effects of dietary protein and calcium on thymus apoptosis induced by fluoride in female rats (Wistar rats).
Malocclusion
TNF Accelerates Death of Mandibular Condyle Chondrocytes in Rats with Biomechanical Stimulation-Induced Temporomandibular Joint Disease.
Massive Hepatic Necrosis
Intrahepatic activation of caspases in human fulminant hepatic failure.
Mastocytoma
Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815.
Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells.
Medulloblastoma
Effects of matrine on the proliferation and apoptosis of human medulloblastoma cell line D341.
Fenretinide (4-HPR) Targets Caspase-9, ERK 1/2 and the Wnt3a/?-Catenin Pathway in Medulloblastoma Cells and Medulloblastoma Cell Spheroids.
The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma.
[Effect of matrine on cell apoptosis and proliferation and the apoptosis related proteins of human medulloblastoma D341 cells in vitro].
Melanoma
A novel dynamic matrix detachment model reveals a shift from apoptosis to necrosis in melanoma cells.
A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma.
Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria.
Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death.
Anticancer effects of Daidzein against the human melanoma cell lines involves cell cycle arrest, autophagy and deactivation of PI3K/AKT signalling pathways.
Antineoplastic Effects and Mechanisms of a New RGD Chimeric Peptide from Bullfrog Skin on the Proliferation and Apoptosis of B16F10 Cells.
Antiproliferation of melanoma cells by polysaccharide isolated from Zizyphus jujuba.
Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents.
Bcl-2 family proteins and cytoskeleton changes involved in DM-1 cytotoxic effect on melanoma cells.
Biphenylalkylacetylhydroquinone ethers suppress the proliferation of murine B16 melanoma cells.
Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.
Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis.
Cisplatin-induced apoptosis in melanoma cells: role of caspase-3 and caspase-7 in Apaf-1 proteolytic cleavage and in execution of the degradative phases.
Curcumin induces cell death in human uveal melanoma cells through mitochondrial pathway.
Diallyl disulfide induces caspase-dependent apoptosis via mitochondria-mediated intrinsic pathway in B16F-10 melanoma cells by up-regulating p53, caspase-3 and down-regulating pro-inflammatory cytokines and nuclear factor-??-mediated Bcl-2 activation.
Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis.
Flavonoids in Ginkgo biloba fallen leaves induce apoptosis through modulation of p53 activation in melanoma cells.
HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis.
IFN-beta pretreatment sensitizes human melanoma cells to TRAIL/Apo2 ligand-induced apoptosis.
IL-24 gene transfer sensitizes melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways.
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma.
Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis.
Inhibition of melanoma growth and metastasis by ATF2-derived peptides.
Inhibitory activity of acteoside in melanoma via regulation of the ER?-Ras/Raf1-STAT3 pathway.
Inverse Association Between Antiviral Immunity and Lupus Disease Activity.
Livin/melanoma inhibitor of apoptosis protein as a potential therapeutic target for the treatment of malignancy.
Markers of mitochondrial dysfunction during the diclofenac-induced apoptosis in melanoma cell lines.
MicroRNA-365 promotes apoptosis in human melanoma cell A375 treated with hydatid cyst fluid of Echinococcus granulosus sensu stricto.
Molecular, Biological and Structural Features of VL CDR-1 Rb44 Peptide, Which Targets the Microtubule Network in Melanoma Cells.
Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways.
P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma.
PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo.
Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis.
Targeting TGF-?-Mediated SMAD Signaling Pathway via Novel Recombinant Cytotoxin II: A Potent Protein from Naja naja oxiana Venom in Melanoma.
The antidepressant sertraline downregulates Akt and has activity against melanoma cells.
The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wnt/?-Catenin Signaling Pathways.
The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines.
TNF-related apoptosis-inducing ligand-induced apoptosis of melanoma is associated with changes in mitochondrial membrane potential and perinuclear clustering of mitochondria.
Topical 2'-Hydroxyflavanone for Cutaneous Melanoma.
Vernolide-A, a sesquiterpene lactone from Vernonia cinerea, induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-?B-mediated bcl-2 activation.
Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms.
Memory Disorders
Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.
Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo.
Meningioma
Role of Caspase-9 Gene Ex5+32 G>A (rs1052576) Variant in Susceptibility to Primary Brain Tumors.
Meningitis
Neuroinflammation trajectories precede cognitive impairment after experimental meningitis-evidence from an in vivo PET study.
Mesothelioma
Effects of cisplatin and panobinostat on human mesothelial (Met-5A) and malignant pleural mesothelioma (MSTO-211H) cells.
Mitochondria determine the efficacy of anti-cancer agents that interact with DNA but not the cytoskeleton.
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Mesothelioma With Bone Metastasis.
Mesothelioma, Malignant
Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells.
Mouth Neoplasms
Anticancer Activity of Apaziquone in Oral Cancer Cells and Xenograft Model: Implications for Oral Cancer Therapy.
Apoptotic effects of dehydrocrenatidine via JNK and ERK pathway regulation in oral squamous cell carcinoma.
Celecoxib derivatives induce apoptosis via the disruption of mitochondrial membrane potential and activation of caspase 9.
Design and characterization of a novel Arthrospira platensis glutathione oxido-reductase-derived antioxidant peptide GM15 and its potent anti-cancer activity via caspase-9 mediated apoptosis in oral cancer cells.
MicroRNA-205 suppresses the oral carcinoma oncogenic activity via down-regulation of Axin-2 in KB human oral cancer cell.
NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance.
Multiple Myeloma
Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance.
Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells.
Caspase polymorphisms and genetic susceptibility to multiple myeloma.
Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells.
Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells.
Genetic variation in cell cycle and apoptosis related genes and multiple myeloma risk.
TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) stable silencing Increases late apoptosis by Upregulation of caspase 9 and APAF1 in RPMI8226 multiple myeloma cell line.
Multiple Sclerosis
CASP-9: A susceptibility locus for multiple sclerosis in Italy.
Multiple System Atrophy
Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy.
Muscular Atrophy
Herbal complex 'Buyang Huanwu Tang' improves motor endplate function of denervated-dependent skeletal muscle atrophy in rat.
Role of caspase-9 in the effector caspases and genome expressions, and growth of bovine skeletal myoblasts.
Targeted suppression of ?-calpain and caspase 9 expression and its effect on caspase 3 and caspase 7 in satellite cells of Korean Hanwoo cattle.
Muscular Diseases
Apoptosis of skeletal muscle on steroid-induced myopathy in rats.
Myocardial Infarction
Butorphanol attenuates myocardial ischemia reperfusion injury through inhibiting mitochondria-mediated apoptosis in mice.
Calcium-sensing receptor-mediated mitogen-activated protein kinase pathway improves the status of transplanted mouse embryonic stem cells in rats with acute myocardial infarction.
Dexmedetomidine alleviates cardiomyocyte apoptosis and cardiac dysfunction may be associated with inhibition of RhoA/ROCK pathway in mice with myocardial infarction.
Mediation of exogenous hydrogen sulfide in recovery of ischemic post-conditioning-induced cardioprotection via down-regulating oxidative stress and up-regulating PI3K/Akt/GSK-3? pathway in isolated aging rat hearts.
MiR-808 inhibits cardiomyocyte apoptosis and expressions of caspase-3 and caspase-9 in rats with myocardial infarction by regulating TGF-?1 signaling pathway.
[Activation of JAK2/STAT3 pathway by CPU0213 alleviates myocardial ischemia-reperfusion and oxidative stress injury in rats].
Myocardial Ischemia
Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging.
[The effects of salidroside on the apoptosis pathway of myocardial cells in acute exhausted rats].
Myocarditis
Enterovirus-related activation of the cardiomyocyte mitochondrial apoptotic pathway in patients with acute myocarditis.
Nasopharyngeal Carcinoma
Indole-3-carbinol inhibits nasopharyngeal carcinoma.
Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma.
Junduqing extractive promotes the apoptosis of nasopharyngeal carcinoma cells through down-regulating Mcl-1 and Bcl-xL and up-regulating Caspase-3, Caspase-8 and Caspase-9.
Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo.
[The inhibited effect of matrine on human nasopharyngeal carcinoma CNE2 cells and the expression of apoptosis related gene Caspase in vitro].
Neoplasm Metastasis
Alzheimer's drug Memantine inhibits metastasis and p-Erk protein expression on 4T1 breast cancer cells.
Carnitine palmitoyl transferase-1A (CPT1A): a new tumor specific target in human breast cancer.
Curcumol inhibits lung adenocarcinoma growth and metastasis via inactivation of PI3K/AKT and Wnt/ß-catenin pathway.
EMP1 regulates caspase-9 and VEGFC expression and suppresses prostate cancer cell proliferation and invasion.
EMP1, a member of a new family of antiproliferative genes in breast carcinoma.
Fenton-reaction-stimulative nanoparticles decorated with a reactive-oxygen-species (ROS)-responsive molecular switch for ROS amplification and triple negative breast cancer therapy.
Fructooligosaccharides and wheat bran fed at similar fermentation levels differentially affect the expression of genes involved in transport, signaling, apoptosis, cell proliferation, and oncogenesis in the colon epithelia of healthy Fischer 344 rats.
Influence of caspases 8 and 9 gene promoter polymorphism on prostate cancer susceptibility and early development of hormone refractory prostate cancer.
In vivo and in vitro inhibition of human gastric cancer progress by upregulating Kank1 gene.
Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis.
Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model.
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Mesothelioma With Bone Metastasis.
[A study on the expression of CASP9 gene and its polymorphism distribution in non-small cell lung cancer]
[Expressions and clinical significances of iASPP and caspase-9 in esophageal cancer].
Neoplasms
125I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts.
3-m-bromoacetylamino benzoic acid ethyl ester: a new cancericidal agent that activates the apoptotic pathway through caspase-9.
9-cis retinoic acid inhibits cumulus cell apoptosis during the maturation of bovine cumulus-oocyte-complexes.
?-Hydroxybutyrate exacerbates lipopolysaccharide/ d-galactosamine-induced inflammatory response and hepatocyte apoptosis in mice.
?-Tocotrienol treatment is more effective against hypoxic tumor cells than normoxic cells: potential implications for cancer therapy.
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis.
A Human Fetal Prostate Xenograft Model of Developmental Estrogenization.
A meta-analysis of caspase 9 polymorphisms in promoter and exon sequence on cancer susceptibility.
A methoxyflavanone derivative from the Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma.
A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects.
A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells.
A plant-based medicinal food inhibits the growth of human gastric carcinoma by reversing epithelial-mesenchymal transition via the canonical Wnt/?-catenin signaling pathway.
A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo.
A protective effect after clearance of orthotopic rat hepatocellular carcinoma by nanosecond pulsed electric fields.
ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro.
Activation of caspase-9 with irradiation inhibits invasion and angiogenesis in SNB19 human glioma cells.
Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.
Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines.
Adenovirus-mediated p53 and ING4 gene co?transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer.
Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death.
Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells.
Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression.
Alkylamino Phenol Derivative Induces Apoptosis by Inhibiting EGFR Signaling Pathway in Breast Cancer Cells.
Aloe-emodin (AE) nanoparticles suppresses proliferation and induces apoptosis in human lung squamous carcinoma via ROS generation in vitro and in vivo.
Ameliorative effect of taurine-chloramine in azathioprine-induced testicular damage; a deeper insight into the mechanism of protection.
An active molecule from Pulsatilla chinensis, Pulsatilla saponin A, induces apoptosis and inhibits tumor growth of human colon cancer cells without or with 5-FU.
An in vivo anti-tumor effect of eckol from marine brown algae by improving the immune response.
An investigation of the immunotoxicity of oil sands processed water and leachates in trout leukocytes.
Analyses of apoptotic regulators CASP9 and DFFA at 1P36.2, reveal rare allele variants in human neuroblastoma tumours.
Analysis of caspase activities in rat mammary tumours induced by N-methyl-nitrosourea.
Analysis of Serum Markers with Regard to Treatment Procedures in Advanced Stage Prostate Cancer Patients.
Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs.
Antagonizing XIAP-mediated caspase-3 inhibition. Achilles' heel of cancers?
Anti-apoptotic and pro-survival effect of exercise training on early aged hypertensive rat cerebral cortex.
Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts.
Anti-cancer activities of metal-based complexes by regulating the VEGF/VEGFR2 signaling pathway and apoptosis-related factors Bcl-2, Bax, and caspase-9 to inhibit angiogenesis and induce apoptosis.
Anti-cancer effect of tectochrysin in NSCLC cells through overexpression of death receptor and inactivation of STAT3.
Anti-Condyloma acuminata mechanism of microRNAs-375 modulates HPV in cervical cancer cells via the UBE3A and IGF-1R pathway.
Anti-Inflammatory and Apoptotic Signaling Effect of Fucoxanthin on Benzo(A)Pyrene-Induced Lung Cancer in Mice.
Anti-inflammatory Role of Mesenchymal Stem Cells in an Acute Lung Injury Mouse Model.
Anti-tumor effects of atractylenolide I isolated from Atractylodes macrocephala in human lung carcinoma cell lines.
Antiapoptotic and mitochondrial biogenetic effects of exercise training on ovariectomized hypertensive rat hearts.
Antiapoptotic effect of exercise training on ovariectomized rat hearts.
Antiapoptotic effects of estrogen in normal and cancer human cervical epithelial cells.
Antibodies against Clonorchis sinensis LDH could cross-react with LDHB localizing on the plasma membrane of human hepatocarcinoma cell SMMC-7721 and induce apoptosis.
Anticancer drug 2-methoxyestradiol protects against renal ischemia/reperfusion injury by reducing inflammatory cytokines expression.
Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines.
Anticancer Effects of Herbal Medicine Compounds and Novel Formulations: a Literature Review.
Antiinflammatory properties of IL-10 rescue small-for-size liver grafts.
Antioxidant-modulated cytotoxicity of silver nanoparticles.
Antiproliferative activity and apoptosis-inducing mechanism of constituents from Toona sinensis on human cancer cells.
Antiproliferative and Apoptotic Effects of Shemamruthaa, a Herbal Preparation, in 7,12-Dimethylbenz(a)Anthracene-Induced Breast Cancer Rats.
Antitumor activity of ginsenoside Rd in gastric cancer via up-regulation of Caspase-3 and Caspase-9.
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die.
Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.
Apollon modulates chemosensitivity in human esophageal squamous cell carcinoma.
Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation.
Apoptosis and heart failure: mechanisms and therapeutic implications.
Apoptosis inducing effects of Kuding tea polyphenols in human buccal squamous cell carcinoma cell line BcaCD885.
Apoptosis induction effect of Apocynum venetum polyphenol on human U87 glioma cells via NF-?B pathway.
Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage.
Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents.
Apoptosis: A biomarker of high-risk phenotype in pediatric acute myeloid leukemia?
Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.
Apple procyanidins induce tumor cell apoptosis through mitochondrial pathway activation of caspase-3.
Arsenic Alters Exosome Quantity and Cargo to Mediate Stem Cell Recruitment Into a Cancer Stem Cell-Like Phenotype.
Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade.
Association of soluble apoptotic markers with impaired left ventricular deformation in patients with rheumatoid arthritis. Effects of inhibition of interleukin-1 activity by anakinra.
Attenuation effect of polydeoxyribonucleotide on inflammatory cytokines and apoptotic factors induced by particulate matter (PM10) damage in human bronchial cells.
Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3? Pathway by Hesperidin in Wistar Rats.
Author Correction: Relationship Between CASP9 and CASP10 Gene Polymorphisms and Cancer Susceptibility: Evidence from an Updated Meta-analysis.
Author Correction: Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling.
Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression.
Autophagy in the physiological endometrium and cancer.
Autophagy Induced by Tumor Necrosis Factor ? Mediates Intrinsic Apoptosis in Trophoblastic Cells.
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
Azoxystrobin Induces Apoptosis of Human Esophageal Squamous Cell Carcinoma KYSE-150 Cells through Triggering of the Mitochondrial Pathway.
Bamboo salt has in vitro anticancer activity in HCT-116 cells and exerts anti-metastatic effects in vivo.
Bax translocation mediated mitochondrial apoptosis and caspase dependent photosensitizing effect of Ficus religiosa on cancer cells.
Benzo(a)pyrene-coated onto Fe2O3 particles-induced apoptotic events in the lungs of Sprague-Dawley rats.
Benzophenone semicarbazone protection strategy for synthesis of aza-glycine containing aza-peptides.
Benzo[f]indole-4,9-dione Derivatives Effectively Inhibit the Growth of Triple-Negative Breast Cancer.
Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways.
Berbamine inhibited the growth of prostate cancer cells in vivo and in vitro via triggering intrinsic pathway of apoptosis.
Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.
Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrest?.
Bicarbonate transport inhibitor SITS modulates pH homeostasis triggering apoptosis of Dalton's lymphoma: implication of novel molecular mechanisms.
Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene therapy induces both extrinsic and intrinsic apoptosis in a rat model of bladder cancer.
Biological characterization of bovine mammary epithelial cell lines immortalized by HPV16 E6/E7 and SV40T.
Biological Potential and Mechanism of Prodigiosin from Serratia marcescens Subsp. lawsoniana in Human Choriocarcinoma and Prostate Cancer Cell Lines.
Boeravinone B alleviates gut dysbiosis during myocardial infarction-induced cardiotoxicity in rats.
Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity.
Bromelain-Induced Apoptosis in GI-101A Breast Cancer Cells.
C1q/tumor necrosis factor-related protein-6 attenuates TNF-?-induced apoptosis in salivary acinar cells via AMPK/SIRT1-modulated miR-34a-5p expression.
C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells.
Cadmium exposure induces apoptosis, inflammation and immunosuppression through CYPs activation and antioxidant dysfunction in common carp neutrophils.
Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-?B pathways.
Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells.
Cancer gene therapy using a survivin mutant adenovirus.
Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.
Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways.
CASP-9 gene functional polymorphisms and cancer risk: A large-scale association study plus meta-analysis.
Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer.
Caspase 9 promoter polymorphisms and risk of primary lung cancer.
Caspase polymorphisms and prognosis of hepatocellular carcinoma.
Caspase-2-induced apoptosis is dependent on caspase-9, but its processing during UV- or tumor necrosis factor-dependent cell death requires caspase-3.
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.
Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.
Caspase-9 as a therapeutic target for treating cancer.
Caspase-9 mediates Puma activation in UCN-01-induced apoptosis.
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease.
Caspase-9: structure, mechanisms and clinical application.
Cassia tora L. (Jue-ming-zi) has anticancer activity in TCA8113 cells in vitro and exerts anti-metastatic effects in vivo.
Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells.
Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro.
Changes in activities of caspase-8 and caspase-9 in human cervical malignancy.
Changes in Glutathione, Oxidative Stress, Mitochondrial Membrane Potential in Apoptosis Involving the Anticancer Activity Of Cantharidin Isolated From Red-Headed Blister Beetles, Epicauta Hirticornis.
Characterization and anti-tumor activity of saponin-rich fractions of South Korean sea cucumbers (Apostichopus japonicus).
Chemotherapy with hybrid liposomes for human breast tumors along with apoptosis in vivo.
Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp.
Citronellol, an Acyclic Monoterpene Induces Mitochondrial-Mediated Apoptosis through Activation of Proapoptotic Factors in MCF-7 and MDA-MB-231 Human Mammary Tumor Cells.
Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia.
Cleavage of survivin by Granzyme M triggers degradation of the survivin-XIAP complex to free caspase activity leading to cytolysis of target tumor cells.
Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma.
Co-transduction of Apaf-1 and caspase-9 augments etoposide-induced apoptosis in U-373MG glioma cells.
Combination of quercetin and cisplatin enhances apoptosis in OSCC cells by downregulating xIAP through the NF-?B pathway.
Combination of TNF-? and graphene oxide-loaded BEZ235 to enhance apoptosis of PIK3CA mutant colorectal cancer cells.
Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells.
Combinatorial effect of zoledronic acid and irradiation on the prevention of DMBA-induced precancerogenic changes in the mammary tissues of rats.
Combined effects of Lenvatinib and iodine-131 on cell apoptosis in nasopharyngeal carcinoma through inducing endoplasmic reticulum stress.
Comparative cytotoxic response of nickel ferrite nanoparticles in human liver HepG2 and breast MFC-7 cancer cells.
Comparative proteomics analysis of caspase-9-protein complexes in untreated and cytochrome c/dATP stimulated lysates of NSCLC cells.
Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro.
Copper-induced tight junction mRNA expression changes, apoptosis and antioxidant responses via NF-?B, TOR and Nrf2 signaling molecules in the gills of fish: preventive role of arginine.
Cordycepin Induced MA-10 Mouse Leydig Tumor Cell Apoptosis through Caspase-9 Pathway.
Costunolide induces mitochondria-mediated apoptosis in human gastric adenocarcinoma BGC-823 cells.
CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.
Cucurbita ficifolia Fruit Extract Induces Tp53/Caspase-Mediated Apoptosis in MCF-7 Breast Cancer Cells.
Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.
Cucurbitacin E induces apoptosis of human prostate cancer cells via cofilin-1 and mTORC1.
Curcumol inhibits lung adenocarcinoma growth and metastasis via inactivation of PI3K/AKT and Wnt/ß-catenin pathway.
CXCL8 gene silencing promotes neuroglial cells activation while inhibiting neuroinflammation through the PI3K/Akt/NF-?B-signaling pathway in mice with ischemic stroke.
CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth.
Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line.
Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells.
Cytotoxic and Antimicrobial Evaluations of Novel Apoptotic and Anti-Angiogenic Spiro Cyclic 2-Oxindole Derivatives of 2-Amino-tetrahydroquinolin-5-one.
Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts.
Cytotoxic effects, inflammatory response and apoptosis induction of cyclophosphamide in the peripheral blood leukocyte of blunt snout bream (Megalobrama amblycephala).
D-Pinitol treatment induced the apoptosis in human leukemia MOLT-4 cells by improved apoptotic signaling pathway.
Daphnane Diterpenoids from Daphne genkwa Inhibit PI3K/Akt/mTOR Signaling and Induce Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells.
Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells.
Debio-0932, a second generation oral Hsp90 inhibitor, induces apoptosis in MCF-7 and MDA-MB-231 cell lines.
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies.
Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt.
Delicaflavone induces apoptosis via mitochondrial pathway accompanying G2/M cycle arrest and inhibition of MAPK signaling cascades in cervical cancer HeLa cells.
Delicaflavone induces ROS-mediated apoptosis and inhibits PI3K/AKT/mTOR and Ras/MEK/Erk signaling pathways in colorectal cancer cells.
Deltonin, a Steroidal Saponin, Inhibits Colon Cancer Cell Growth in Vitro and Tumor Growth in Vivo via Induction of Apoptosis and Antiangiogenesis.
Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production.
Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in human HaCaT keratinocytes.
Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation.
Design and Synthesis of Novel Anti-Proliferative Emodin Derivatives and Studies on their Cell Cycle Arrest, Apoptosis Pathway and Migration.
Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells.
Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA.
Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives.
Design, Synthesis and Pharmacological Evaluation of Three Novel Dehydroabietyl Piperazine Dithiocarbamate Ruthenium (II) Polypyridyl Complexes as Potential Antitumor Agents: DNA Damage, Cell Cycle Arrest and Apoptosis Induction.
Developing a circularly permuted variant of Renilla luciferase as a bioluminescent sensor for measuring Caspase-9 activity in the cell-free and cell-based systems.
Development and In Vitro Evaluation of 2-Methoxyestradiol Loaded Polymeric Micelles for Enhancing Anticancer Activities in Prostate Cancer.
Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.
Development of an alternative zebrafish model for drug-induced intestinal toxicity.
Dietary isothiocyanate iberin inhibits growth and induces apoptosis in human glioblastoma cells.
Dietary turmeric post-treatment decreases DMBA-induced hamster buccal pouch tumor growth by altering cell proliferation and apoptosis-related markers.
Differential caspase-9-dependent signaling pathway between tumor necrosis factor receptor- and Fas-mediated hepatocyte apoptosis in mice.
Diindolylmethane and Lupeol Modulates Apoptosis and Cell Proliferation in N-Butyl-N-(4-Hydroxybutyl) Nitrosamine Initiated and Dimethylarsinic Acid Promoted rat Bladder Carcinogenesis.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors.
DK1 Induces Apoptosis via Mitochondria-Dependent Signaling Pathway in Human Colon Carcinoma Cell Lines In Vitro.
DNA targeting polyaza macrobicyclic dizinc(II) complexes promoting high in vitro caspase dependent anti-proliferative activity against human carcinoma cancer cells.
DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.
Dose-dependent protective effect of baicalin against testicular torsion-detorsion in rats.
Down regulation of caspase-9 is a frequent event in patients with stage II colorectal cancer and correlates with poor clinical outcome.
Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer.
Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance.
Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma.
E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation.
Effectiveness and Anticancer Activity of a Novel Phenolic Compound from Garcinia porrecta Against the MCF-7 Breast Cancer Cell Line in vitro and in silico.
Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells.
Effects of Caspase 9 Gene Polymorphism in Patients with Prostate Cancer.
Effects of Caspase-9 and Survivin Gene Polymorphisms in Pancreatic Cancer Risk and Tumor Characteristics.
Effects of dapagliflozin in experimental sepsis model in rats.
Effects of early administration of insulin-like growth factor-1 on cognitive function in septic encephalopathy.
Effects of long-term dehydration on oxidative stress, apoptotic markers and neuropeptides in the gastric mucosa of the dromedary camel.
Effects of matrine in combination with cisplatin on liver cancer.
Effects of oxaliplatin on inflammation and intestinal floras in rats with colorectal cancer.
Effects of trans-resveratrol on type 1 diabetes-induced up-regulation of apoptosis and mitogen-activated protein kinase signaling in retinal pigment epithelium of Dark Agouti rats.
Effects of treatment of rats with indole-3-carbinol on apoptosis in the mammary gland and mammary adenocarcinomas.
Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma.
Embelin: a benzoquinone possesses therapeutic potential for the treatment of human cancer.
Emetine regulates the alternative splicing of caspase 9 in tumor cells.
Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons.
Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells.
Enhanced susceptibility to apoptosis and growth arrest of human breast carcinoma cells treated by silica nanoparticles loaded with monohydroxy flavone compounds.
Ent-Dihydrotucumanoic acid promotes apoptosis in PC-3 human prostate cancer cells.
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
Erinacine Facilitates the Opening of the Mitochondrial Permeability Transition Pore Through the Inhibition of the PI3K/ Akt/GSK-3? Signaling Pathway in Human Hepatocellular Carcinoma.
Evaluation of Apoptosis Induction by Newcastle Disease Virus LaSota Strain in Human Breast Carcinoma Cells.
Evaluation of Caspase-9b and PP2Ac?2 as potential biomarkers for chronic lymphocytic leukemia.
Evaluation of the association between biochemical and immunohistochemical score of caspase-9 and TNF?, and the grading of lumbar disc herniation.
Evaluation of the Potential Diagnostic Utility of the Determination of Selected Caspases-Markers Involved in the Regulation of Apoptosis-In Patients with Ovarian Cancer.
Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis.
Exposure of pregnant sows to deoxynivalenol during 35-70 days of gestation does not affect pathomorphological and immunohistochemical properties of fetal organs.
Expression analysis of caspase-6, caspase-9 and BNIP3 in prostate cancer.
Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: Caspase-8 and caspase-9 is associated with poor prognosis.
Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma.
Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems.
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.
Fish oil improves learning impairments of diabetic rats by blocking PI3K/AKT/nuclear factor-?B-mediated inflammatory pathways.
gamma-Tocopheryl quinone induces apoptosis in cancer cells via caspase-9 activation and cytochrome c release.
Ganoderma atrum polysaccharide induces antitumor activity via the mitochondrial apoptotic pathway related to activation of host immune response.
Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients.
Gene expression study related with the intrinsic pathway of apoptosis in bladder cancer by real-time PCR technique.
Gene-viro-therapy targeting liver cancer by a dual-regulated oncolytic adenoviral vector harboring IL-24 and TRAIL.
Genetic determinants that influence hypoxia-induced apoptosis.
Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells.
Glycosylation of anthocyanins enhances the apoptosis of colon cancer cells by handicapping energy metabolism.
Gramine inhibits angiogenesis and induces apoptosis via modulation of TGF-? signalling in 7,12 dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinoma.
HBXIP, a binding protein of HBx, regulates maintenance of the G2/M phase checkpoint induced by DNA damage and enhances sensitivity to doxorubicin-induced cytotoxicity.
Heat shock and tumor necrosis factor-alpha induce apoptosis in bovine preimplantation embryos through a caspase-9-dependent mechanism.
Heat shock protein 70-2 (HSP70-2) a novel cancer testis antigen that promotes growth of ovarian cancer.
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
Herbal formula of Bushen Jianpi combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle.
HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo.
High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation.
High-Resolution Magic Angle Spinning (1)H NMR Spectroscopy and Reverse Transcription-PCR Analysis of Apoptosis in a Rat Glioma.
Hiltonol Cocktail Kills Lung Cancer Cells by Activating Cancer-Suppressors, PKR/OAS, and Restraining the Tumor Microenvironment.
hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing.
Host-Defense Peptides Caerin 1.1 and 1.9 Stimulate TNF-Alpha-Dependent Apoptotic Signals in Human Cervical Cancer HeLa Cells.
HSP70 inhibitor combined with cisplatin suppresses the cervical cancer proliferation in vitro and transplanted tumor growth: An experimental study.
Human Chorionic Gonadotropin Suppresses Human Breast Cancer Cell Growth Directly via p53-mediated Mitochondrial Apoptotic Pathway and Indirectly via Ovarian Steroid Secretion.
Human hepatocellular carcinoma in a mouse model: assessment of tumor response to percutaneous ablation by using glyceraldehyde-3-phosphate dehydrogenase antagonists.
HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells.
Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo.
Hypothyroidism reduces mammary tumor progression via ?-catenin-activated intrinsic apoptotic pathway in rats.
Hypoxia-Inducible Factor 1-? (HIF-1?) Induces Apoptosis of Human Uterosacral Ligament Fibroblasts Through the Death Receptor and Mitochondrial Pathways.
Hypoxic preconditioning potentiates the trophic effects of mesenchymal stem cells on co-cultured human primary hepatocytes.
Identification of an antitumor effect of demethylzeylasteral on human gastric cancer cells.
Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.
Ifosfamide-loaded lipid-core-nanocapsules to increase the anticancer efficacy in MG63 osteosarcoma cells.
Imbalance of the mitochondrial pro- and anti-apoptotic mediators in neuroblastoma tumours with unfavourable biology.
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas.
Immunocytochemical expression of a panel of markers in pleural effusions from patients with primary lung adenocarcinoma.
Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters.
Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors.
Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer.
Implication of calpain in caspase activation during B cell clonal deletion.
Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy.
In situ activation and monitoring of the evolution of the intracellular caspase family.
In vitro and in vivo anti-cancer activities of Kuding tea (Ilex kudingcha C.J. Tseng) against oral cancer.
In vitro Anticancer Effects of Stilbene Derivatives: Mechanistic Studies on HeLa and MCF-7 Cells.
In vitro infection of bovine monocytes with Mycoplasma bovis delays apoptosis and suppresses production of gamma interferon and tumor necrosis factor alpha but not interleukin-10.
Inactivated Sendai Virus Strain Tianjin Induces Apoptosis in Breast Cancer MCF-7 Cells by Promoting Caspase Activation and Fas/FasL Expression.
Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance.
Indole-3-carbinol inhibits nasopharyngeal carcinoma.
Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol.
Induction of apoptosis in cancer cells by NiZn ferrite nanoparticles through mitochondrial cytochrome C release.
Induction of apoptosis of human lung carcinoma cells by hybrid liposomes containing polyoxyethylenedodecyl ether.
Induction of caspase-9, biochemical assessment and morphological changes caused by apoptosis in cancer cells treated with goniothalamin extracted from Goniothalamus macrophyllus.
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.
Influence of a leptin deficiency on testicular morphology, germ cell apoptosis, and expression levels of apoptosis-related genes in the mouse.
Influence of caspases 8 and 9 gene promoter polymorphism on prostate cancer susceptibility and early development of hormone refractory prostate cancer.
Inhibition of caspase-9 by oridonin, a diterpenoid isolated from Rabdosia rubescens, augments apoptosis in human laryngeal cancer cells.
Inhibition of human glioma U251 cells growth in vitro and in vivo by hydroxyapatite nanoparticle-assisted delivery of short hairpin RNAs against SATB1.
Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta?
Inhibition of non-neuronal alpha7-nicotinic receptor reduces tumorigenicity in A549 NSCLC xenografts.
Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin.
Inhibition of Stat3 Activity by YC-1 Enhances Chemo-Sensitivity in Hepatocellular Carcinoma.
Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma.
Inhibitors of apoptosis confer resistance to tumour suppression by adoptively transplanted cytotoxic T-lymphocytes in vitro and in vivo.
Inhibitory activity of acteoside in melanoma via regulation of the ER?-Ras/Raf1-STAT3 pathway.
Inhibitory activity of flaxseed oil against CdCl2 induced liver and kidney damage: Histopathology, genotoxicity, and gene expression study.
Integrative in silico and in vitro transcriptomics analysis revealed new lncRNAs related to intrinsic apoptotic genes in colorectal cancer.
Intra-arterially infused carbon dioxide-saturated solution for sensitizing the anticancer effect of cisplatin in a rabbit VX2 liver tumor model.
Intranasal Administration of Type V Collagen Reduces Lung Carcinogenesis through Increasing Endothelial and Epithelial Apoptosis in a Urethane-Induced Lung Tumor Model.
Investigation of the Inhibitory Effect of Platycodin D in Human Transitional Cell Carcinoma Cell Line 5637.
Investigation of U-251 cell death triggered by flavonoid luteolin: towards a better understanding on its anticancer property against glioblastomas.
In vivo and in vitro inhibition of human gastric cancer progress by upregulating Kank1 gene.
Isolation of 4,4'-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma.
JNK2 silencing and caspase-9 activation by hyperosmotic polymer inhibits tumor progression.
Lentivirus-mediated RNA interference targeting E2F-1 inhibits human gastric cancer MGC-803 cell growth in vivo.
Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways.
Lipid Nanocarriers of a Lipid-Conjugated Estrogenic Derivative Inhibit Tumor Growth and Enhance Cisplatin Activity against Triple-Negative Breast Cancer: Pharmacokinetic and Efficacy Evaluation.
LncRNA POU3F3 promotes proliferation and inhibits apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9.
Long non-coding RNA LINC00607 silencing exerts antioncogenic effects on thyroid cancer through the CASP9 Promoter methylation.
Long noncoding RNA LINC00662-miR-15b-5p mediated GPR120 dysregulation contributes to osteoarthritis.
Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma.
Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization.
Low concentrations of trichosanthin induce apoptosis and cell cycle arrest via c-Jun N-terminal protein kinase/mitogen-activated protein kinase activation.
Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway.
Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells.
MAPT (Tau) expression is a biomarker for an increased rate of survival in pediatric neuroblastoma.
Marker genes to predict sensitivity to FK228, a histone deacetylase inhibitor.
mda-7/IL-24 induces apoptosis in human GBC-SD gallbladder carcinoma cells via mitochondrial apoptotic pathway.
Mechanism of action for N-substituted benzamide-induced apoptosis.
Metastasized lung cancer suppression by Morinda citrifolia (Noni) leaf compared to Erlotinib via anti-inflammatory, endogenous antioxidant responses and apoptotic gene activation.
Method to Measure Sphingomyelin Synthase Activity Changes in Response to CD95L.
MicroRNA-7641 is a regulator of ribosomal proteins and a promising targeting factor to improve the efficacy of cancer therapy.
MicroRNA-based recombinant AAV vector assembly improves efficiency of suicide gene transfer in a murine model of lymphoma.
miR-1269 promotes cell survival and proliferation by targeting tp53 and caspase-9 in lung cancer.
MiR-153 promotes breast cancer cell apoptosis by targeting HECTD3.
miR-187-5p/apaf-1 axis was involved in oxidative stress-mediated apoptosis caused by ammonia via mitochondrial pathway in chicken livers.
Mitochondrial dysfunction mediated apoptosis of HT-29 cells through CS-PAC-AgNPs and investigation of genotoxic effects in zebra (Danio rerio) fish model for drug delivery.
Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells.
Mitogen-activated protein kinase phosphatase-1 prevents lipopolysaccharide-induced apoptosis in immature rat intestinal epithelial cells.
Modulation of Apoptosis by Cytotoxic Mediators and Cell-Survival Molecules in Sjögren's Syndrome.
Molecular evidence of apoptotic death in malignant brain tumors including glioblastoma multiforme: upregulation of calpain and caspase-3.
Monascus purpureus induced apoptosis on gastric cancer cell by scavenging mitochondrial reactive oxygen species.
Monocyte survival factors induce Akt activation and suppress caspase-3.
Moringa Oleifera Gold Nanoparticles Modulate Oncogenes, Tumor Suppressor Genes and Caspase-9 Splice Variants in A549 Cells.
mRNA Expression of Bax, Bcl-2, p53, Cathepsin B, Caspase-3 and Caspase-9 in the HepG2 Cell Line Following Induction by a Novel Monoclonal Ab Hep88 mAb: Cross-Talk for Paraptosis and Apoptosis.
Multiple effects of hyperbaric oxygen on the expression of HIF-1 alpha and apoptotic genes in a global ischemia-hypotension rat model.
Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas.
Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9.
MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways.
Nanomedicine-based paclitaxel induced apoptotic signaling pathways in A562 leukemia cancer cells.
Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains.
Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, G?q and G?11 and kill uveal melanoma cells.
Neuroprotection of netrin-1 on neurological recovery via Wnt/?-catenin signaling pathway after spinal cord injury.
New chalcone derivative exhibits antiproliferative potential by inducing G2/M cell cycle arrest, mitochondrial-mediated apoptosis and modulation of MAPK signalling pathway.
NF-?B pathway took part in the development of apoptosis mediated by miR-15a and oxidative stress via mitochondrial pathway in ammonia-treated chicken splenic lymphocytes.
NF-kappaB does not influence the induction of apoptosis by ukrain.
Novel anticancer activity of the autocleaved ovotransferrin against human colon and breast cancer cells.
Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis.
Novel functional profiling approach combining reverse phase protein microarrays and human 3-D ex vivo tissue cultures: expression of apoptosis-related proteins in human colon cancer.
Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells.
Novel polysaccharide extracted from Sipunculus nudus inhibits HepG2 tumour growth in vivo by enhancing immune function and inducing tumour cell apoptosis.
Oral treatment with herbal formula B307 alleviates cardiac failure in aging R6/2 mice with Huntington's disease via suppressing oxidative stress, inflammation, and apoptosis.
Oral treatment with the herbal formula B307 alleviates cardiac toxicity in doxorubicin-treated mice via suppressing oxidative stress, inflammation, and apoptosis.
Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells.
Overcoming drug-resistant lung cancer by paclitaxel loaded dual-functional liposomes with mitochondria targeting and pH-response.
Overexpression of caspase-9 triggers its activation and apoptosis in vitro.
P2X7 receptor-mediated apoptosis of human cervical epithelial cells.
p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells.
PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets.
Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells.
Peptide-functionalized upconversion nanoparticles-based FRET sensing platform for Caspase-9 activity detection in vitro and in vivo.
PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1.
Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8.
Photodynamic Therapy of Pheophorbide a Inhibits the Proliferation of Human Breast Tumour via Both Caspase-dependent and -independent Apoptotic Pathways in In Vitro and In Vivo Models.
Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice.
Photoluminescent And Self-Assembled Hyaluronic Acid-Zinc Oxide-Ginsenoside Rh2 Nanoparticles And Their Potential Caspase-9 Apoptotic Mechanism Towards Cancer Cell Lines.
Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549).
Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.
Polyclonal rabbit anti-human ovarian cancer globulins inhibit tumor growth through apoptosis involving the caspase signaling.
Polymorphisms of Caspase 8 and Caspase 9 gene and colorectal cancer susceptibility and prognosis.
Polyphyllin I inhibits the growth of ovarian cancer cells in nude mice.
Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.
Potent Antitumor Activity of Oncolytic Adenovirus Expressing mda-7/IL-24 for Colorectal Cancer.
Potent antitumor activity of oncolytic adenovirus expressing mda-7/IL-24 for colorectal cancer.
Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration.
Prefrontal Cortex and Hippocampus Inflammation in Mice Fed High-Carbohydrate or High-Fat Diets.
Preparation of curcumin micelles and the in vitro and in vivo evaluation for cancer therapy.
Preparation, Characterization and In-vitro Biological Evaluation of Novel Curcumin Derivatives as Cytotoxic and Apoptosis-Inducing Agents.
Preparation, Optimization and In-Vitro Evaluation of Curcumin-Loaded Niosome@calcium Alginate Nanocarrier as a New Approach for Breast Cancer Treatment.
Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro.
Proliferation index: a continuous model to predict prognosis in patients with tumours of the Ewing's sarcoma family.
Protection of mitochondrial perturbation by human T-lymphotropic virus type 1 tax through induction of Bcl-xL expression.
Protective effect of 5-HT7 receptor activation against glutamate-induced neurotoxicity in human neuroblastoma SH-SY5Y cells via antioxidative and antiapoptotic pathways.
Protective effect of cannabidiol against cadmium hepatotoxicity in rats.
Protective effects of dioscin against alcohol-induced liver injury.
Protective effects of miR-155-5p silencing on IFN-?-induced apoptosis and inflammation in salivary gland epithelial cells.
Protective effects of St. John's wort in the hepatic ischemia/reperfusion injury in rats.
Protective effects of the ethanolic extract of Melia toosendan fruit against colon cancer.
Protein kinase C inhibitor and irradiation-induced apoptosis: relevance of the cytochrome c-mediated caspase-9 death pathway.
Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.
Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways.
Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
Radix Tetrastigma Inhibits the Non-Small Cell Lung Cancer via Bax/Bcl-2/Caspase-9/Caspase-3 Pathway.
Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic.
Recombinant adenovirus Ad-RUNrf2 reduces paraquat-induced A549 injury.
Relationship Between CASP9 and CASP10 Gene Polymorphisms and Cancer Susceptibility: Evidence from an Updated Meta-analysis.
Relationship of possible biomarkers with malignancy of thymic tumors: a meta-analysis.
Renal Cell Carcinoma Tumors Induce T Cell Apoptosis through Receptor-Dependent and Receptor-Independent Pathways.
Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L).
Resistance of human astrocytoma cells to apoptosis induced by mitochondria-damaging agents: possible implications for anticancer therapy.
Retinoic acid amide inhibits JAK/STAT pathway in lung cancer which leads to apoptosis.
Rhein Augments Antiproliferative Effects of Atezolizumab Based on Breast Cancer (4T1) Regression.
Role of the CASP-9 Ex5+32 G>A polymorphism in susceptibility to cancer: A meta-analysis.
Role of TLR4/MyD88/NF-?B signaling in the contrast-induced injury of renal tubular epithelial cells.
S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-? signaling pathway in cancer cells.
SB203580 Modulates p38 MAPK Signaling and Dengue Virus-Induced Liver Injury by Reducing MAPKAPK2, HSP27, and ATF2 Phosphorylation.
Scinderin is a novel transcriptional target of BRMS1 involved in regulation of hepatocellular carcinoma cell apoptosis.
Secretory leukoprotease inhibitor inhibits cell growth through apoptotic pathway on ovarian cancer.
Sensitization of tumor cells to Apo2 ligand/TRAIL-induced apoptosis by inhibition of casein kinase II.
Shrimp shells extracted chitin in silver nanoparticle synthesis: Expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells.
Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels.
Silver oxide nanoparticles alleviate indomethacin-induced gastric injury: a novel antiulcer agent.
Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line.
SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo.
SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than gemcitabine.
Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis.
Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer.
SRSF1 Regulates the Alternative Splicing of Caspase 9 Via A Novel Intronic Splicing Enhancer Affecting the Chemotherapeutic Sensitivity of Non-Small Cell Lung Cancer Cells.
Stomach cancer highly expresses both initiator and effector caspases; an immunohistochemical study.
Strawberry Leaf Extract Treatment Alleviates Cognitive Impairment by Activating Nrf2/HO-1 Signaling in Rats With Streptozotocin-Induced Diabetes.
Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea.
Stryphnodendron adstringens ("Barbatimão") Leaf Fraction: Chemical Characterization, Antioxidant Activity, and Cytotoxicity Towards Human Breast Cancer Cell Lines.
Study of RNA Interference Targeting NET-1 Combination with Sorafenib for Hepatocellular Carcinoma Therapy In Vitro and In Vivo.
Study on the anti-hepatocarcinoma effect and molecular mechanism of Prunella vulgaris total flavonoids.
Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells.
Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer.
Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model.
Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination.
Synergistic Anticancer Effects of Formononetin and Temozolomide on Glioma C6 Cells.
Synergistic tumor growth-inhibitory effect of the prostate-specific antigen-activated fusion peptide BSD352 for prostate cancer therapy.
Synthesis of Tolmetin Hydrazide-Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells.
Synthesis, characterization, and anticancer activity of Schiff bases.
Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling.
t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism.
Tanshinone IIA inhibits human gastric carcinoma AGS cell growth by decreasing BiP, TCTP, Mcl?1 and Bcl?xL and increasing Bax and CHOP protein expression.
Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer.
Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9.
Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy.
TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model.
TGF-?1 protection against A?1-42-induced hippocampal neuronal inflammation and apoptosis by T?R-I.
The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.
The anti-tumor activities of cerebrosides derived from sea cucumber Acaudina molpadioides and starfish Asterias amurensis in vitro and in vivo.
The antiangiogenic agent Neovastat (AE-941) induces endothelial cell apoptosis.
The AP-2alpha transcription factor regulates tumor cell migration and apoptosis.
The bioactive ingredients in Actinidia chinensis Planch. Inhibit liver cancer by inducing apoptosis.
The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.
The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand.
The combination effects of Shen-Ling-Bai-Zhu on promoting apoptosis of transplanted H22 hepatocellular carcinoma in mice receiving chemotherapy.
The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells.
The effect of salmon calcitonin against glutamate-induced cytotoxicity in the C6 cell line and the roles the inflammatory and nitric oxide pathways play.
The growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82 is inhibited by the resveratrol oligomers hopeaphenol and r2-viniferin.
The interaction between the light source dose and caspase-dependent and -independent apoptosis in human SK-MEL-3 skin cancer cells following photodynamic therapy with zinc phthalocyanine: A comparative study.
The long noncoding RNA XIAP-AS1 promotes XIAP transcription by XIAP-AS1 interacting with Sp1 in gastric cancer cells.
The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.
The mitochondria-targeting antioxidant MitoQ alleviated Lipopolysaccharide/ D-galactosamine-induced acute liver injury in mice.
The non-apoptotic role of caspase-9 promotes differentiation in leukemic cells.
The Novel Akt Inhibitor API-1 Induces c-FLIP Degradation and Synergizes with TRAIL to Augment Apoptosis Independent of Akt Inhibition.
The potential tumour suppressor role for caspase-9 (CASP9) in the childhood malignancy, neuroblastoma.
The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells.
The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice.
The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells.
Therapeutic effect and apoptosis mechanism of lung-tonifying and expectorant decoction on lung cancer rats with Qi deficiency and blood stasis.
Thiamine Alleviates High-Concentrate-Diet-Induced Oxidative Stress, Apoptosis, and Protects the Rumen Epithelial Barrier Function in Goats.
Three immunomarker support vector machines-based prognostic classifiers for stage IB non-small-cell lung cancer.
Thymoquinone ameliorates testicular tissue inflammation induced by chronic administration of oral sodium nitrite.
Toll-like receptor 4 mediates the antitumor host response induced by Ganoderma atrum polysaccharide.
TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer's A?.
Transcript expression and genetic variability analysis of caspases in breast carcinomas suggests CASP9 as the most interesting target.
Transcutaneous application of carbon dioxide (CO2) induces mitochondrial apoptosis in human malignant fibrous histiocytoma in vivo.
Transferrin-Conjugated Erianin-Loaded Liposomes Suppress the Growth of Liver Cancer by Modulating Oxidative Stress.
TRIAP1 Inhibition Activates the Cytochrome c/Apaf-1/Caspase-9 Signaling Pathway to Enhance Human Ovarian Cancer Sensitivity to Cisplatin.
Trichinella pseudospiralis infection is characterized by more continuous and diffuse myopathy than T. spiralis infection.
Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promotion of apoptosis.
TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells.
Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling.
Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4R? overexpressed melanoma models.
Tumor necrosis factor-related apoptosis-inducing ligand additive with Iodine-131 of inhibits non-small cell lung cancer cells through promoting apoptosis.
Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.
Tumor-induced apoptosis of T cells: amplification by a mitochondrial cascade.
Tumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo.
Tumor-targeted Nanoparticle Delivery of HuR siRNA Inhibits Lung Tumor Growth In Vitro and In Vivo By Disrupting the Oncogenic Activity of the RNA-binding Protein HuR.
Tuning of apoptosis-mediator gene transcription in HepG2 human hepatoma cells through an adenosine signal.
Two Trichothecene Mycotoxins from Myrothecium roridum Induce Apoptosis of HepG-2 Cells via Caspase Activation and Disruption of Mitochondrial Membrane Potential.
Upregulation of CASP9 through NF-?B and Its Target MiR-1276 Contributed to TNF?-promoted Apoptosis of Cancer Cells Induced by Doxorubicin.
Valproate augments Niraparib killing of tumor cells.
Verteporfin inhibits cell proliferation and induces apoptosis in different subtypes of breast cancer cell lines without light activation.
Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9.
Zinc chloride inhibits human lens epithelial cell migration and proliferation involved in TGF-?1 and TNF-? signaling pathways in HLE B-3 cells.
Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS.
[Anti-hepatoma effects of Smac analogue Birinapant and its related molecular mechanism].
[Clinical and Functional Importance of Selected CASP8 and CASP9 Polymorphisms in Breast Carcinoma].
[Effect of Ferula ferulaeoides on growth and apoptosis of human gastric cancer MGC-803 transplantation tumor in nude mice].
[Effect of p38MAPK gene silencing on expression of oncogenes and apoptotic genes induced by PM(2.5) in hepatocytes].
[Effects of Buzhong Yiqi decoction on expression of Bad, NF-?B, caspase-9, Survivin, and mTOR in nude mice with A549/DDP transplantation tumors].
[Expression of caspase 9 and p53 in uterine leiomyosarcomas].
[Expressions and clinical significances of iASPP and caspase-9 in esophageal cancer].
[iPSC-derived rejuvenated T-cell therapy for Epstein-Barr virus-associated lymphomas].
[Mda-7-carrying replication-defective adenovirus selectively kills hepatocellular carcinoma cells by facilitating release of proapoptotic protein from mitochondria]
[Studies on mechanism of myricetin-induced apoptosis in human hepatocellular carcinoma HepG-2 cells]
[Study on Apoptosis of Oral Squamous Carcinoma Cell line KB and KBv200 induced by Survivin RNAi.]
[Synergistic effects and mechanisms of combined tumor necrosis factor-related apoptosis-inducing ligand and chemotherapeutic drugs or radiotherapy in killing laryngeal squamous carcinoma cells in vitro]
[The role for oxidative stress in neurodegenerative diseases]
{beta}2-Microglobulin Is a Signaling and Growth-Promoting Factor for Human Prostate Cancer Bone Metastasis.
Neoplasms, Germ Cell and Embryonal
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Nervous System Diseases
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease.
Neural Tube Defects
Genetic screening and functional analysis of CASP9 mutations in a Chinese cohort with neural tube defects.
Key apoptotic genes APAF1 and CASP9 implicated in recurrent folate-resistant neural tube defects.
Rare mutations inapoptosis related genes APAF1, CASP9, and CASP3 contribute to human neural tube defects.
The role of cell death in regulating the size and shape of the mammalian forebrain.
Neurilemmoma
Gene therapy with apoptosis-associated speck-like protein (ASC), a newly described schwannoma tumor suppressor, inhibits schwannoma growth in vivo.
Neuroblastoma
A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells.
Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death.
Analyses of apoptotic regulators CASP9 and DFFA at 1P36.2, reveal rare allele variants in human neuroblastoma tumours.
Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways.
Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases.
Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.
CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals.
Chemotherapy-induced apoptosis of S-type neuroblastoma cells requires caspase-9 and is augmented by CD95/Fas stimulation.
Curcumin inhibits oxidative stress-induced TRPM2 channel activation, calcium ion entry and apoptosis values in SH-SY5Y neuroblastoma cells: Involvement of transfection procedure.
DNA-damaging drug-induced apoptosis sensitized by N-myc in neuroblastoma cells.
Ellagic acid induces a dose- and time-dependent depolarization of mitochondria and activation of caspase-9 and -3 in human neuroblastoma cells.
Essential Role for p53 and Caspase-9 in DNA Damaging Drug-Induced Apoptosis in Neuroblastoma IMR32 Cells.
Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells.
Insulin promotes survival of amyloid-beta oligomers neuroblastoma damaged cells via caspase 9 inhibition and Hsp70 upregulation.
Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity.
Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.
Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells.
Leucine to proline substitution by SNP at position 197 in Caspase-9 gene expression leads to neuroblastoma: a bioinformatics analysis.
Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity.
Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation.
Mangiferin prevents the impairment of mitochondrial dynamics and an increase in oxidative stress caused by excessive fluoride in SH-SY5Y cells.
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
Pre-processed caspase-9 contained in mitochondria participates in apoptosis.
The effect of caspase-9 in the differentiation of SH-SY5Y cells.
The N-myc paradox: N-myc overexpression in neuroblastomas is associated with sensitivity as well as resistance to apoptosis.
The potential tumour suppressor role for caspase-9 (CASP9) in the childhood malignancy, neuroblastoma.
The role of caspases 9 and 9-short (9S) in death ligand- and drug-induced apoptosis in human astrocytoma cells.
Neurodegenerative Diseases
Caspase-9.
Neurofibromatoses
MicroRNA-373 promotes the development of esophageal squamous cell carcinoma by targeting LATS2 and OXR1.
Neurofibromatosis 2
MicroRNA-373 promotes the development of esophageal squamous cell carcinoma by targeting LATS2 and OXR1.
Neuroinflammatory Diseases
Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice.
Non-alcoholic Fatty Liver Disease
Caspase 3, 6, 8, and 9 Gene Expression in Peripheral Blood Leukocytes and Plasma Concentrations of IL-6 and TNF-? in Carriers of Different Polymorphic Marker -174G>C Genotypes of IL6 Gene Associated with the Risk of Nonalcoholic Steatohepatitis.
Effects of 4-nonylphenol on oxidant/antioxidant balance system inducing hepatic steatosis in male rat.
[Effects of three Wenyang Jianpi Tang on cell proliferation and apoptosis of nonalcoholic fatty liver cells].
Obesity
The coexistence of nocturnal sustained hypoxia and obesity additively increases cardiac apoptosis.
[Soluble apoptosis markers in obese patients with food intolerance].
Oligospermia
Caspase signalling pathways in human spermatogenesis.
Opisthorchiasis
Effect of curcumin on pathogenesis of hamster-opisthorchiasis through apoptosis-related gene expression.
Optic Atrophy
Antiapoptotic and mitochondrial biogenetic effects of exercise training on ovariectomized hypertensive rat hearts.
Optic Atrophy, Autosomal Dominant
Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens.
Osteoarthritis
ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage.
Osteoarthritis, Knee
[Effects of inner-heating acupuncture on apoptosis of chondrocytes and expression of Caspase-3 and Caspase-9 in rats with knee osteoarthritis].
Osteoporosis
Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling.
Osteosarcoma
Actein Inhibits Cell Proliferation and Migration in Human Osteosarcoma.
Aluminium blunts the proliferative response and increases apoptosis of cultured human cells: putative relationship to alzheimer's disease.
Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines.
ClC-5 Downregulation Induces Osteosarcoma Cell Apoptosis by Promoting Bax and tBid Complex Formation.
Downregulation of microRNA-95-3p suppresses cell growth of osteosarcoma via CDKN1A/p21 expression.
LncRNA SNHG20 knockdown suppresses the osteosarcoma tumorigenesis through the mitochondrial apoptosis pathway by miR-139/RUNX2 axis.
MicroRNA-34a inhibits tumor invasion and metastasis in osteosarcoma partly by effecting C-IAP2 and Bcl-2.
Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells.
Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway.
Zinc promotes cell apoptosis via activating the Wnt-3a/?-catenin signaling pathway in osteosarcoma.
Ototoxicity
Hwanggunchungyitang prevents cadmium-induced ototoxicity through suppression of the activation of caspase-9 and extracellular signal-related kinase in auditory HEI-OC1 cells.
Ovarian Neoplasms
(-)-Asarinin from the Roots of Asarum sieboldii Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells.
Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.
Berbamine suppresses cell proliferation and promotes apoptosis in ovarian cancer partially via the inhibition of Wnt/?-catenin signaling.
Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors.
Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line.
Costunolide Inhibits the Growth of OAW42-A Multidrug-Resistant Human Ovarian Cancer Cells by Activating Apoptotic and Autophagic Pathways, Production of Reactive Oxygen Species (ROS), Cleaved Caspase-3 and Cleaved Caspase-9.
Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance.
Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells.
Effect of small interfering RNA transfection on FAK and DLC1 mRNA expression in OVCAR-3.
Enhancement of cisplatin-induced apoptosis by ?-elemene in resistant human ovarian cancer cells.
Evaluation of the Potential Diagnostic Utility of the Determination of Selected Caspases-Markers Involved in the Regulation of Apoptosis-In Patients with Ovarian Cancer.
Impact of the histone deacetylase inhibitor trichostatin A on active uptake, volume-sensitive release of taurine, and cell fate in human ovarian cancer cells.
MAPT (Tau) expression is a biomarker for an increased rate of survival in pediatric neuroblastoma.
Phosphorylation of caspase-9 at Thr125 directs paclitaxel resistance in ovarian cancer.
Polyphyllin I inhibits the growth of ovarian cancer cells in nude mice.
Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
Preclinical activity of the liposomal cisplatin lipoplatin in ovarian cancer.
Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model.
Targeting Ovarian Cancer and Chemoresistance Through Selective Inhibition of Sphingosine Kinase-2 with ABC294640.
Trichostatin a restores apaf-1 function in chemoresistant ovarian cancer cells.
Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway.
palmitoyl[protein] hydrolase deficiency
Palmitoyl-protein thioesterase-1 deficiency leads to the activation of caspase-9 and contributes to rapid neurodegeneration in INCL.
Pancreatic Neoplasms
Apoptosis and anergy of T cell induced by pancreatic stellate cells-derived galectin-1 in pancreatic cancer.
Effects of Caspase-9 and Survivin Gene Polymorphisms in Pancreatic Cancer Risk and Tumor Characteristics.
Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells.
The mitochondrion interfering compound NPC-26 exerts potent anti-pancreatic cancer cell activity in vitro and in vivo.
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cells.
Pancreatitis
Caspase-9 acts as a regulator of necroptotic cell death.
Effects of emodin on intestinal mucosal barrier by the upregulation of miR-218a-5p expression in rats with acute necrotizing pancreatitis.
Genetic Susceptibility in Acute Pancreatitis: Genotyping of GSTM1, GSTT1, GSTP1, CASP7, CASP8, CASP9, CASP10, LTA, TNFRSF1B, and TP53 Gene Variants.
Papilledema
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.
Papilloma
A synthetic coumarin (4-Methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice.
Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.
Paracoccidioidomycosis
Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients.
Paralysis
Dysequilibrium between caspases and their inhibitors in a mouse model for amyotrophic lateral sclerosis.
Parasitic Diseases
Fas/CD95-mediated apoptosis of type II cells is blocked by Toxoplasma gondii primarily via interference with the mitochondrial amplification loop.
Parkinson Disease
A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration.
A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo.
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease.
Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease.
Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of Parkinson's disease does not involve activation of caspase-9 and caspase-3.
Perinatal Death
Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.
Periodontal Diseases
Immune response mediated by Th1 / IL-17 / caspase-9 promotes evolution of periodontal disease.
The role of caspase-8, caspase-9, and apoptosis inducing factor in periodontal disease.
Periodontitis
Porphyromonas gingivalis Differentially Modulates Apoptosome Apoptotic Peptidase Activating Factor 1 in Epithelial Cells and Fibroblasts.
Regulation of Anti-Apoptotic SOD2 and BIRC3 in Periodontal Cells and Tissues.
Persistent Infection
Increased expressions of ADAMTS-13 and apoptosis contribute to neuropathology during Toxoplasma gondii encephalitis in mice.
Pheochromocytoma
Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.
Phosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosis.
Pneumonia
Suppression of alveolar macrophage apoptosis prolongs survival of rats and mice with pneumocystis pneumonia.
Pneumonia, Pneumocystis
Caspase-9 as a target for Pneumocystis pneumonia therapy.
Polycystic Kidney, Autosomal Dominant
Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD).
Pre-Eclampsia
Effect of hypoxia on expression of placental trophoblast cells SATB1 and ?-catenin and its correlation with the pathogenesis of preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Purification and characterization of a cytotoxic neurotoxin-like protein from Naja haje haje venom that induces mitochondrial apoptosis pathway.
Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells.
Primary Myelofibrosis
Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms.
Prostatic Neoplasms
A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model.
A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-(XL).
Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer.
Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer.
Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1-Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells.
Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition.
Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-?B Inhibition.
Development, Optimization and Evaluation of 2-Methoxy-Estradiol Loaded Nanocarrier for Prostate Cancer.
Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation.
Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
Effect of laminin tyrosine-isoleucine-glycine-serine-arginine peptide on the growth of human prostate cancer (PC-3) cells in vitro.
Effects of Caspase 9 Gene Polymorphism in Patients with Prostate Cancer.
Emetine regulates the alternative splicing of caspase 9 in tumor cells.
EMP1 regulates caspase-9 and VEGFC expression and suppresses prostate cancer cell proliferation and invasion.
Enhanced therapeutic effect of cisplatin on the prostate cancer in tumor-bearing mice by transfecting the attenuated Salmonella carrying a plasmid co-expressing p53 gene and mdm2 siRNA.
Estrogen receptor ? upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer.
Expression analysis of caspase-6, caspase-9 and BNIP3 in prostate cancer.
HAX-1 inhibits apoptosis in prostate cancer through the suppression of caspase-9 activation.
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.
Influence of caspases 8 and 9 gene promoter polymorphism on prostate cancer susceptibility and early development of hormone refractory prostate cancer.
Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway.
Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells.
Knockdown of zinc finger protein X-linked inhibits prostate cancer cell proliferation and induces apoptosis by activating caspase-3 and caspase-9.
LncRNA PVT1 predicts prognosis and regulates tumor growth in prostate cancer.
LncRNA UNC5B-AS1 promotes malignant progression of prostate cancer by competitive binding to caspase-9.
Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.
microRNA-323 upregulation promotes prostate cancer growth and docetaxel resistance by repressing p73.
Molecular mechanisms of resveratrol (3,4,5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive prostate cancer cells.
PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.
SGO1 induces proliferation and metastasis of prostate cancer through AKT-mediated signaling pathway.
Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction.
Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells.
[Sanggenon C induces apoptosis of prostate cancer PC3 cells by activating caspase 3 and caspase 9 pathways].
Pulmonary Disease, Chronic Obstructive
The role of bronchial epithelial cell apoptosis in the pathogenesis of COPD.
Pulmonary Edema
MicroRNA-146a overexpression alleviates intestinal ischemia/reperfusion-induced acute lung injury in mice.
Pulmonary Fibrosis
Restoring microRNA-499-5p Protects Sepsis-Induced Lung Injury Mice Via Targeting Sox6.
[Effects of curcumin on apoptosis of pulmonary fibroblasts from rats]
Radicular Cyst
Effect of calcium hydroxide as intracanal medicament on the expression of caspase-9 located within the radicular cyst epithelium.
Rectal Neoplasms
Association between main Caspase gene polymorphisms and the susceptibility and prognosis of colorectal cancer.
Reperfusion Injury
Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia.
MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis.
Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats.
Retinal Degeneration
Light Induces Ultrastructural Changes in Rod Outer and Inner Segments, Including Autophagy, in a Transgenic Xenopus laevis P23H Rhodopsin Model of Retinitis Pigmentosa.
Retinal Detachment
FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment.
Inhibition of Retinal Detachment-induced Apoptosis in Photoreceptors by a Small Peptide Inhibitor of the Fas Receptor.
Retinal Vein Occlusion
Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.
Retinoblastoma
cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells.
d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway.
In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells.
Luteolin induces apoptosis in oral squamous cancer cells.
Rhabdomyosarcoma
Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin.
Salmonella Infections
Characterization of Salmonella-induced cell death in human macrophage-like THP-1 cells.
Sarcoma
IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via repression of FLICE-like protein expression.
Sarcoma 180
Antitumorpharmacological mechanism of the oral liquid of Poriacocos polysaccharide.
Sarcoma, Ewing
miR-185 suppresses progression of Ewing's sarcoma via inhibiting the PI3K/AKT and Wnt/?-catenin pathways.
Sarcoma, Kaposi
Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.
Sarcopenia
Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats.
Seizures
2R,4R-APDC, a Metabotropic Glutamate Receptor Agonist, Reduced Neuronal Apoptosis by Upregulating MicroRNA-128 in a Rat Model After Seizures.
Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons.
Bcl-2 and Caspase-9 serum levels in children and adolescents with idiopathic epilepsy and active seizures.
Cortical expression of IL1-?, Bcl-2, Caspase-3 and 9, SEMA-3a, NT-3 and P-glycoprotein as biological markers of intrinsic severity in drug-resistant temporal lobe epilepsy.
Do hyperbaric oxygen-induced seizures cause brain damage?
Ferulic acid ameliorates pentylenetetrazol-induced seizures by reducing neuron cell death.
Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death.
[The expression of Smac and XIAP in rat hippocampus following limbic seizure induced by kainic acid injection into amygdaloid nucleus]
Sepsis
Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity.
Local thymic caspase-9 inhibition improves survival during polymicrobial sepsis in mice.
Role of Exogenous Hsp72 on Liver Dysfunction during Sepsis.
Survivin and caspases serum protein levels and survivin variants mRNA expression in sepsis.
Sleep Initiation and Maintenance Disorders
Integrative analysis of genome-wide association study and brain region related enhancer maps identifies biological pathways for insomnia.
Spinal Cord Compression
[Effects of decompression combined with electro-acupuncture on rat with acute severe upper cervical spinal cord compression injury].
Spinal Cord Injuries
Effects of combined and individual use of N-methyl-D aspartate receptor antagonist magnesium sulphate and caspase-9 inhibitor z-LEDH-fmk in experimental spinal cord injury.
Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury.
Neuroprotection of netrin-1 on neurological recovery via Wnt/?-catenin signaling pathway after spinal cord injury.
Upregulation of miR-199a-5p Protects Spinal Cord Against Ischemia/Reperfusion-Induced Injury via Downregulation of ECE1 in Rat.
Spinal Dysraphism
Apoptosis, Expression of PAX3 and P53, and Caspase Signal in Fetuses with Neural Tube Defects.
Squamous Cell Carcinoma of Head and Neck
Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.
CASP9 c.-1339A>G and CASP3 c.-1191A>G polymorphisms alter susceptibility and clinical aspects of head and neck squamous cell carcinoma.
Caspase-9 regulates cisplatin-induced apoptosis in human head and neck squamous cell carcinoma cells.
Effect of ethanol extracts of Antrodia cinnamomea on head and neck squamous cell carcinoma cell line.
GSTP1 c.313A>G, XPD c.934G>A, XPF c.2505T>C and CASP9 c.-1339A>G Polymorphisms and Severity of Vomiting in Head and Neck Cancer Patients treated with Cisplatin Chemoradiation.
Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells.
Influence of CASP9 c.-1339A>G and CASP3 c.-1191A>G variants in outcome of patients with head and neck squamous cell carcinoma.
Inhibition of caspase-9 activity and Apaf-1 expression in cisplatin-resistant head and neck squamous cell carcinoma cells.
Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma.
The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells.
[Effects of salinomycin on proliferation and apoptosis of oral squamous cell carcinoma].
[Inhibition of caspase-9 activity in cisplatin-resistant head and neck squamous cell carcinoma]
Starvation
Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells.
Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q.
Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway.
HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice.
Multiple death pathways in retina-derived 661W cells following growth factor deprivation: crosstalk between caspases and calpains.
Neuropeptide Y enhances proliferation and prevents apoptosis in rat bone marrow stromal cells in association with activation of the Wnt/?-catenin pathway in vitro.
Non-suckling starvation of neonatal mice promotes primordial follicle formation with activation of ovarian autophagy.
Status Epilepticus
Caspase-dependent programmed cell death pathways are not activated in generalized seizure-induced neuronal death.
[Effect of recombinant human erythropoietin on hippocampal p-Akt and caspase-9 expressions in rats with status epilepticus and the mechanism]
Stomach Neoplasms
Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling.
Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.
Antitumor activity of ginsenoside Rd in gastric cancer via up-regulation of Caspase-3 and Caspase-9.
Baicalin extracted from Huangqin (Radix Scutellariae Baicalensis) induces apoptosis in gastric cancer cells by regulating B cell lymphoma (Bcl-2)/Bcl-2-associated X protein and activating caspase-3 and caspase-9.
Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer.
Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways.
Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer.
Downregulation of AKT and MDM2, Melatonin Induces Apoptosis in AGS and MGC803 Cells.
Dysregulated Expression of Apoptosis-Associated Genes and MicroRNAs and Their Involvement in Gastric Carcinogenesis.
Effects of celecoxib on cycle kinetics of gastric cancer cells and protein expression of cytochrome C and caspase-9.
Esculetin exerts antitumor effect on human gastric cancer cells through IGF-1/PI3K/Akt signaling pathway.
Esculetin induces apoptosis in human gastric cancer cells through a cyclophilin D-mediated mitochondrial permeability transition pore associated with ROS.
Exogenous morphine inhibits human gastric cancer MGC- 803 cell growth by cell cycle arrest and apoptosis induction.
Identification of an alternative form of caspase-9 in human gastric cancer cell lines: a role of a caspase-9 variant in apoptosis resistance.
Immune clearance gastric carcinoma cells in ascites by activating caspase-9-induced apoptosis.
In vivo and in vitro inhibition of human gastric cancer progress by upregulating Kank1 gene.
miR-877-5p antagonizes the promoting effect of SP on the gastric cancer progression.
NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells.
Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms.
Prognostic significance of mRNA expression of CASPs in gastric cancer.
Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation.
RP11-874J12.4, a novel lncRNA, confers chemoresistance in human gastric cancer cells by sponging miR-3972 and upregulating SSR2 expression.
The effect of aloe-emodin-induced photodynamic activity on the apoptosis of human gastric cancer cells: A pilot study.
Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo.
Ultrafine particles of Ulmus davidiana var. japonica induce apoptosis of gastric cancer cells via activation of caspase and endoplasmic reticulum stress.
Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1.
[Association of CASP3 and CASP9 polymorphisms with genetic susceptibility to stomach cancer].
[Changes in the number of copies of genetic loci in gastric cancer].
[Chinese herbal medicine Euphorbia esula extract induces apoptosis and inhibits the proliferation, migration and invasion of multidrug resistant gastric carcinoma cells].
[Effect of Ferula ferulaeoides on growth and apoptosis of human gastric cancer MGC-803 transplantation tumor in nude mice].
[Effects of betulinic acid on apoptosis of human gastric cancer MGC-803 cells].
[Expressions of gastrin and apoptosis-associated proteins involved in mitochondrial pathway in gastric cancer tissues and the clinical significance].
[Study on apoptosis of human stomach SGC-7901 cells induced by extracts of Solanum lyratum]
[Toosendanin induces apoptosis of human gastric cancer MGC-803 cells and its mechanism].
Stroke
Association Between a Polymorphism in CASP3 and CASP9 Genes and Ischemic Stroke.
Caspase-9.
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.
Testicular Neoplasms
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Thrombocythemia, Essential
Effects of polymorphic DNA genes involved in BER and caspase pathways on the clinical outcome of myeloproliferative neoplasms under treatment with hydroxyurea.
The Role of Caspase Genes Polymorphisms in Genetic Susceptibility to Philadelphia-Negative Myeloproliferative Neoplasms in a Portuguese Population.
Thrombocytopenia
Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function.
Thrombocytosis
Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms.
Thrombosis
Breaking symmetry in protein dimers: designs and functions.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Cypermethrin Alters the Expression Profile of mRNAs in the Adult Rat Striatum: A Putative Mechanism of Postnatal Pre-exposure Followed by Adulthood Re-exposure-Enhanced Neurodegeneration.
Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems.
Relationship of possible biomarkers with malignancy of thymic tumors: a meta-analysis.
Thyroid Cancer, Papillary
Role of Caspase 8, Caspase 9 and Bcl-2 polymorphisms in papillary thyroid carcinoma risk in Han Chinese population.
Thyroid Carcinoma, Anaplastic
Cytochrome c release is upstream to activation of caspase-9, caspase-8, and caspase-3 in the enhanced apoptosis of anaplastic thyroid cancer cells induced by manumycin and paclitaxel.
Thyroid Neoplasms
Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP.
CXCR4/RhoA signaling pathway is involved in miR-128-regulated proliferation and apoptosis of human thyroid cancer cells.
Long non-coding RNA LINC00607 silencing exerts antioncogenic effects on thyroid cancer through the CASP9 Promoter methylation.
Proteomic expression profiling of thyroid neoplasms.
Tongue Neoplasms
Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways.
Tricuspid Valve Insufficiency
Mitochondrial apoptotic pathway activation in the atria of heart failure patients due to mitral and tricuspid regurgitation.
Triple Negative Breast Neoplasms
Comparative proteomic profiling of triple-negative breast cancer reveals that up-regulation of RhoGDI-2 is associated to the inhibition of caspase 3 and caspase 9.
LncRNA POU3F3 promotes proliferation and inhibits apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9.
MicroRNA-224 Promotes Tumorigenesis through Downregulation of Caspase-9 in Triple-Negative Breast Cancer.
Targeted inhibition of Notch1 gene enhances the killing effects of paclitaxel on triple negative breast cancer cells.
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells.
Tuberculosis
Bim is a crucial regulator of apoptosis induced by Mycobacterium tuberculosis.
Involvement of caspase-9 in the inhibition of necrosis of RAW 264 cells infected with Mycobacterium tuberculosis.
Monocytes from tuberculosis patients that exhibit cleaved caspase 9 and denaturalized cytochrome c are more susceptible to death mediated by Toll-like receptor 2.
Urinary Bladder Neoplasms
Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells.
Brucea javanica oil induces apoptosis in T24 bladder cancer cells via upregulation of caspase-3, caspase-9, and inhibition of NF-kappaB and COX-2 expressions.
Caspase 9 and Caspase 8 Gene Polymorphisms and Susceptibility to Bladder Cancer in North Indian Population.
Diindolylmethane and Lupeol Modulates Apoptosis and Cell Proliferation in N-Butyl-N-(4-Hydroxybutyl) Nitrosamine Initiated and Dimethylarsinic Acid Promoted rat Bladder Carcinogenesis.
Gene expression study related with the intrinsic pathway of apoptosis in bladder cancer by real-time PCR technique.
Heptaphylline suppresses the proliferation and migration of human bladder cancer cells via induction of intrinsic apoptosis, autophagy and inhibition of ?-catenin signalling pathway.
Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells.
Potential therapeutic effects of N-butylidenephthalide from Radix Angelica Sinensis (Danggui) in human bladder cancer cells.
Uterine Cervical Neoplasms
Anti-Condyloma acuminata mechanism of microRNAs-375 modulates HPV in cervical cancer cells via the UBE3A and IGF-1R pathway.
Beclin 1-mediated macroautophagy involves regulation of caspase-9 expression in cervical cancer HeLa cells.
Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9.
Inhibition of ADP-ribosylation factor-like 6 interacting protein 1 suppresses proliferation and reduces tumor cell invasion in CaSki human cervical cancer cells.
Realgar-induced apoptosis of cervical cancer cell line Siha via cytochrome C release and caspase-3 and caspase-9 activation.
Synergistic anticancer activity of dietary tea polyphenols and bleomycin hydrochloride in human cervical cancer cell: Caspase-dependent and independent apoptotic pathways.
Tafazzin (TAZ) promotes the tumorigenicity of cervical cancer cells and inhibits apoptosis.
Vaccinia
Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens.
Extracts from rabbit skin inflamed by the vaccinia virus attenuate bupivacaine-induced spinal neurotoxicity in pregnant rats.
Structural Determinants of Caspase-9 Inhibition by the Vaccinia Virus Protein, F1L.
Vaccinia virus protein F1L is a caspase-9 inhibitor.
Varicocele
Dysregulated apoptosis through the intrinsic pathway in the internal spermatic vein of patients with varicocele.
Sperm caspase-9 in oligoasthenoteratozoospermic men with and without varicocele.
Varicose Veins
Dysregulated apoptosis in primary varicose veins.
Ventricular Dysfunction, Left
Activation of caspase-3 may not contribute to postresuscitation myocardial dysfunction.
Ventricular Fibrillation
Targeting mitochondria for resuscitation from cardiac arrest.
Vertigo
CASP9 genotype confers gentamicin susceptibility in intratympanic treatment of intractable vertigo caused by Ménière's disease.
Vesicular Stomatitis
Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway.
Virus Diseases
Approaches to the removal of T-lymphocytes to minimize graft-versus-host disease in patients with primary immunodeficiencies who do not have a matched sibling donor.
Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection.
Tioman virus infection in experimentally infected mouse brain and its association with apoptosis.
Variability in apoptotic response to poliovirus infection.
[Antagonism of baicalin on cell cyclical distribution and cell apoptosis in A549 cells infected with influenza A (H1N1) virus].
Whooping Cough
Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways.
LPA protects intestinal epithelial cells from apoptosis by inhibiting the mitochondrial pathway.