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acetyl-WEHD-7-amido-4-methylcoumarin + H2O
acetyl-WEHD + 7-amino-4-methylcoumarin
-
optimal tetrapeptide recognition motif
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-
?
interleukin-1beta + H2O
?
-
50 nM enzyme partly cleaves interleukin-1beta into the 28000 Da form and a very faint 17500 Da band can be detected, with other dilutions of TY no cleavage is detected
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-
?
MDIGAYPHFMPTNLAGDPY + H2O
AYPHFMPTNLA + AYPHFMPTNLAGD + DIGAYPHFMPTNLAG + IGAYPHFMPTNLAGD + MDIGAYPHFMPTNL + MDIGAYPHFMPTNLA + MDIGAYPHFMPTNLAGD + MDIGAYPHFMPTNLAGDP + Met + MDIG + Met-Asp + Tyr + Pro-Tyr + GDPY + DPY
-
-
quantitative product mass spectrometric analysis, overview
-
?
pro-caspase-3 + H2O
p12 + pro-p17
-
-
-
?
pro-caspase-5 + H2O
?
caspase-5 has protease activity on its own precursor
-
-
?
succinyl-YVAD-7-amido-4-methylcoumarin + H2O
succinyl-YVAD + 7-amino-4-methylcoumarin
-
-
-
-
?
WEHD-4-nitroanilide + H2O
WEHD + 4-nitroaniline
-
-
-
-
?
additional information
?
-
additional information
?
-
the enzyme fails to process the interleukin-1beta precursor, activity is dependent on the presence of a cysteine residue at position 245
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-
?
additional information
?
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-
very little efficiency on caspase-1 substrates
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-
?
additional information
?
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the enzyme cleaves the substrates in the order of increasing efficiency: p35, pro-caspase-3, CrmA
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-
?
additional information
?
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-
the preferred cleavage sequence is WEHD-/- or LEHD-/-
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-
?
additional information
?
-
-
the preferred cleavage sequence is WEHD-/- or LEHD-/-
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-
?
additional information
?
-
-
overexpression induces apoptosis
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-
?
additional information
?
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-
the enzyme is involved in cytokine activation
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-
?
additional information
?
-
the enzyme is able to induce apoptosis when overexpressed in COS cells
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-
?
additional information
?
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the production of the enzyme induces the activation of an endogenous 32000 Da putative cysteine protease (CPP32) like caspase
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?
additional information
?
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-
Ich-3 may mediate apoptosis induced by granzyme B. Ich-3 does not process pro-interleukin-1beta directly but does promote pro-interleukin-1beta processing by ICE. Ich-3 may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE
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-
?
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Arthritis, Rheumatoid
The association between caspase-5 gene polymorphisms and rheumatoid arthritis in a Chinese population.
Asthma
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma.
Breast Neoplasms
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Carcinogenesis
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Carcinoma
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Carcinoma
TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder.
Cholera
Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes.
Colorectal Neoplasms
BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability.
Colorectal Neoplasms
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Cowpox
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.
Endometrial Neoplasms
Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.
Gastrointestinal Neoplasms
Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.
Infections
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.
Infections
Development of an ex vivo Tissue Platform to Study the Human Lung Response to Coxiella burnetii.
Infections
Leishmania infantum infection reduces the amyloid ?42-stimulated NLRP3 inflammasome activation.
Infections
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Infections
SERPINB1-mediated checkpoint of inflammatory caspase activation.
Leukemia
Frameshift mutations in caspase-5 and other target genes in leukemia and lymphoma cell lines having microsatellite instability.
Lung Neoplasms
Somatic mutation of the Caspase-5 gene in human lung cancer.
Lymphoma
Frameshift mutations in caspase-5 and other target genes in leukemia and lymphoma cell lines having microsatellite instability.
Macular Degeneration
Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1? and MCP-1 in cultured human retinal pigment epithelial cells.
Neoplasm Metastasis
Somatic mutation of the Caspase-5 gene in human lung cancer.
Neoplasms
Association of Caspases with an Increased Prostate Cancer Risk in North Indian Population.
Neoplasms
BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability.
Neoplasms
Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer.
Neoplasms
Defective DNA-mismatch repair: a potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia.
Neoplasms
Effects of elevated ammonium on the transcriptome of stony coral Pocillopora damicornis.
Neoplasms
Expressional changes of genes and miRNA in common megakaryocyte-erythroid progenitors from lower-risk myelodysplastic syndrome.
Neoplasms
Flow cytometry analysis of apoptotic progression and expression analysis of four apoptosis-related genes in Penaeus vannamei in response to white spot syndrome virus infection.
Neoplasms
Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.
Neoplasms
Identification of biomarkers predicting the chemotherapeutic outcomes of capecitabine and oxaliplatin in patients with gastric cancer.
Neoplasms
Indication of participation of caspase-2 and caspase-5 in mechanisms of human cervical malignancy.
Neoplasms
Microsatellite mutations of transforming growth factor-beta receptor type II and caspase-5 occur in human precursor T-cell lymphoblastic lymphomas/leukemias in vivo but are not associated with hMSH2 or hMLH1 promoter methylation.
Neoplasms
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Neoplasms
Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndrome.
Neoplasms
Somatic mutation of the Caspase-5 gene in human lung cancer.
Osteosarcoma
MiR-218 promotes apoptosis of U2OS osteosarcoma cells through targeting BIRC5.
Psoriasis
Association of angiopoietin-1, angiopoietin-2 and caspase-5 polymorphisms with psoriasis vulgaris.
Psoriasis
Caspase-5 expression is upregulated in lesional psoriatic skin.
Psoriasis
Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation.
Retinoblastoma
Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.
Salmonella Infections
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Sarcoma
Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity.
Sepsis
Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.
Skin Diseases
Caspase-5 expression is upregulated in lesional psoriatic skin.
Urinary Bladder Neoplasms
TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder.
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Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
brenda
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
brenda
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens
brenda
Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
J. Biol. Chem.
272
17907-17911
1997
Homo sapiens
brenda
Wang, S.; Miura, M.; Jung, Y.K.; Zhu, H.; Gagliardini, V.; Shi, L.; Greenberg, A.H.; Yuan, J.
Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE
J. Biol. Chem.
271
20580-20587
1996
Mus musculus
brenda
Faucheu, C.; Blanchet, A.M.; Collard-Dutilleul, V.; Lalanne, J.L.; Diu-Hercend, A.
Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme
Eur. J. Biochem.
236
207-213
1996
Homo sapiens (P51878)
brenda
Munday N.A.; Vaillancourt J.P.; Ali A.; Casano F.J.; Miller D.K.; Molineaux S.M.; Yamin T.T.; Yu V.L.; Nicholson D.W.
Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases
J. Biol. Chem.
270
15870-15876
1995
Homo sapiens (P51878)
brenda
Kamada, S.; Funahashi, Y.; Tsujimoto, Y.
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases
Cell Death Differ.
4
473-478
1997
Homo sapiens
brenda
Fassy, F.; Krebs, O.; Rey, H.; Komara, B.; Gillard, C.; Capdevila, C.; Yea, C.; Faucheu, C.; Blanchet, A.M.; Miossec, C.; Diu-Hercend, A.
Enzymic activity of two caspases related to interleukin-1beta-converting enzyme
Eur. J. Biochem.
253
76-83
1998
Homo sapiens
brenda
Eckhart, L.; Kittel, C.; Gawlas, S.; Gruber, F.; Mildner, M.; Jilma, B.; Tschachler, E.
Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants
Biochem. Biophys. Res. Commun.
348
682-688
2006
Homo sapiens (P51878), Homo sapiens
brenda
Trojan, J.; Brieger, A.; Raedle, J.; Weber, N.; Kriener, S.; Kronenberger, B.; Caspary, W.F.; Zeuzem, S.
BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability
Int. J. Colorectal Dis.
19
538-544
2004
Homo sapiens
brenda
Offman, J.; Gascoigne, K.; Bristow, F.; Macpherson, P.; Bignami, M.; Casorelli, I.; Leone, G.; Pagano, L.; Sica, S.; Halil, O.; Cummins, D.; Banner, N.R.; Karran, P.
Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndrome
Mol. Cancer Res.
3
251-260
2005
Homo sapiens
brenda
Gao, J.; Wells, J.A.
Identification of specific tethered inhibitors for caspase-5
Chem. Biol. Drug Des.
79
209-215
2012
Homo sapiens
brenda
Bian, Z.M.; Elner, S.G.; Khanna, H.; Murga-Zamalloa, C.A.; Patil, S.; Elner, V.M.
Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells
Invest. Ophthalmol. Vis. Sci.
52
8646-8656
2011
Homo sapiens
brenda
Lopez, D.; Jimenez, M.; Garcia-Calvo, M.; Del Val, M.
Concerted antigen processing of a short viral antigen by human caspase-5 and -10
J. Biol. Chem.
286
16910-16913
2011
Homo sapiens
brenda
Bitto, N.J.; Baker, P.J.; Dowling, J.K.; Wray-McCann, G.; De Paoli, A.; Tran, L.S.; Leung, P.L.; Stacey, K.J.; Mansell, A.; Masters, S.L.; Ferrero, R.L.
Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes
Immunol. Cell Biol.
96
1120-1130
2018
Homo sapiens (P51878), Homo sapiens
brenda
Vigano, E.; Diamond, C.E.; Spreafico, R.; Balachander, A.; Sobota, R.M.; Mortellaro, A.
Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
Nat. Commun.
6
8761
2015
Homo sapiens (P51878), Homo sapiens
brenda
Hattinger, E.; Wolf, R.
Caspase-5 rescues UVB-dependent IL-1beta activity in ASC-deficient epidermal keratinocytes
Photodermatol. Photoimmunol. Photomed.
32
165-167
2016
Homo sapiens (P51878)
brenda