Disease on EC 3.4.22.53 - calpain-2 and Organism(s) Homo sapiens
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Acidosis
Influence of glutamine infusion on ubiquitin, caspase-3, cathepsins L and B, and m-calpain expression in sheep with nutritionally induced metabolic acidosis.
Adenocarcinoma
Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas.
Alzheimer Disease
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.
Alzheimer Disease
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Alzheimer Disease
Comparison of Ca(2+)-activated proteinase enzyme and endogenous inhibitor activity in brain tissue from normal and Alzheimer's disease cases.
Alzheimer Disease
Hypoxia-Triggered m-Calpain Activation Evokes Endoplasmic Reticulum Stress and Neuropathogenesis in a Transgenic Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects.
Alzheimer Disease
m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains.
Alzheimer Disease
Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment.
Anthrax
Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.
Aortic Aneurysm
Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms.
Aortic Aneurysm, Abdominal
Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice.
Aortic Aneurysm, Abdominal
Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice.
Arsenic Poisoning
[Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25].
Arthritis
Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice.
Arthritis
Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.
Arthritis, Rheumatoid
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis.
Arthritis, Rheumatoid
Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis.
Astrocytoma
Human U87 astrocytoma cell invasion induced by interaction of ?ig-h3 with integrin ?5?1 involves calpain-2.
Ataxia
Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques.
Atherosclerosis
Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.
Atherosclerosis
m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis.
Atrial Fibrillation
[Calpain-2 and calcineurin protein expression in right atrial appendages from patients underwent valve replacement with or without atrial fibrillation].
Blindness
Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury.
Brain Injuries
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study.
Brain Injuries, Traumatic
Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death.
Brain Injuries, Traumatic
Casein zymogram assessment of mu-calpain and m-calpain activity after traumatic brain injury in the rat in vivo.
Brain Injuries, Traumatic
Degradation of ?II-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.
Brain Injuries, Traumatic
Erratum to: Degradation of ?II-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.
Brain Injuries, Traumatic
Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats.
Brain Injuries, Traumatic
pH dependency of mu-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat.
Brain Injuries, Traumatic
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study.
Brain Ischemia
Neuroprotective mechanism of taurine due to up-regulating calpastatin and down-regulating calpain and caspase-3 during focal cerebral ischemia.
Brain Ischemia
Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity.
Brain Ischemia
RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia.
Breast Neoplasms
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.
Breast Neoplasms
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Breast Neoplasms
Calpain system protein expression in basal-like and triple-negative invasive breast cancer.
Breast Neoplasms
Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy.
Breast Neoplasms
Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype.
Breast Neoplasms
Cytoplasmic FOXP1 expression is correlated with ER and calpain II expression and predicts a poor outcome in breast cancer.
Breast Neoplasms
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Breast Neoplasms
Hematopoietic PBX-interacting protein (HPIP) is over expressed in breast infiltrative ductal carcinoma and regulates cell adhesion and migration through modulation of focal adhesion dynamics.
Breast Neoplasms
Hyperactivated m-calpain affects acquisition of doxorubicin resistance in breast cancer cells.
Breast Neoplasms
Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer.
Breast Neoplasms
The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy.
Brucellosis
Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2.
calpain-2 deficiency
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
calpain-2 deficiency
Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.
Carcinogenesis
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Carcinogenesis
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Carcinoma
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Carcinoma
Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.
Carcinoma
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.
Carcinoma
Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma.
Carcinoma, Hepatocellular
Apoptosis by aloe-emodin is mediated through downregulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells.
Carcinoma, Hepatocellular
Calpains are required for invasive and metastatic potentials of human HCC cells.
Carcinoma, Hepatocellular
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway.
Carcinoma, Non-Small-Cell Lung
Noninvasive Early Detection of Calpain 2-Enriched Non-Small Cell Lung Cancer Using a Human Serum Albumin-Bounded Calpain 2 Nanosensor.
Carcinoma, Non-Small-Cell Lung
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.
Cardiomegaly
Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction.
Cardiotoxicity
Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity.
Cardiotoxicity
Cardiac protective effects of dexrazoxane on animal cardiotoxicity model induced by anthracycline combined with trastuzumab is associated with upregulation of calpain-2.
Cataract
Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse.
Cataract
alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract.
Cataract
Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64.
Cataract
Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract.
Cataract
Buthionine sulfoximine induced cataracts in mice contain insolubilized crystallins with calpain II cleavage sites.
Cataract
Calpain II induced insolubilization of lens beta-crystallin polypeptides may induce cataract.
Cataract
Cataract and the acceleration of calpain-induced beta-crystallin insolubilization occurring during normal maturation of rat lens.
Cataract
Changes in calpain II mRNA in young rat lens during maturation and cataract formation.
Cataract
Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses.
Cataract
Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR).
Cataract
Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice.
Cataract
Fatty acids influence the efficacy of lutein in the modulation of ?-crystallin chaperone function: Evidence from selenite induced cataract rat model.
Cataract
General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice.
Cataract
Hydration and elevated calcium alone do not produce xylose nuclear cataract: role of proteolysis by calpain.
Cataract
Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains.
Cataract
Involvement of calpain 2 in ionomycin-induced cell death in cultured mouse lens epithelial cells.
Cataract
Loss of calpastatin leads to activation of calpain in human lens epithelial cells.
Cataract
Mass measurements of C-terminally truncated alpha-crystallins from two-dimensional gels identify Lp82 as a major endopeptidase in rat lens.
Cataract
Origin of urea-soluble protein in the selenite cataract. Role of beta-crystallin proteolysis and calpain II.
Cataract
Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats.
Cataract
Purification of calpain II from rat lens and determination of endogenous substrates.
Cataract
Regional distribution of free calcium in selenite cataract: relation to calpain II.
Cataract
[The expression of calpain II in rat lens epithelial cells of hydrogen peroxide-induced cataract]
Colitis-Associated Neoplasms
Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.
Colonic Neoplasms
Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme.
Colorectal Neoplasms
Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.
Colorectal Neoplasms
Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme.
Colorectal Neoplasms
Correction: New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status.
Colorectal Neoplasms
New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status.
Corticobasal Degeneration
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Craniocerebral Trauma
Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor.
Diabetes Mellitus, Type 2
Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.
Diabetes Mellitus, Type 2
Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes.
Down Syndrome
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Endometrial Neoplasms
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in endometrial cancer.
Epilepsy
Calpain-2 activation in mouse hippocampus plays a critical role in seizure-induced neuropathology.
Eye Abnormalities
General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice.
Frontotemporal Dementia
Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment.
Glioblastoma
Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2.
Glioblastoma
Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment.
Granuloma
Cellular distribution of proteolytic enzymes in the skeletal muscle of sarcoid myopathy.
Head Injuries, Closed
Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor.
Heart Failure
Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury.
Heart Valve Diseases
[Calpain-2 and calcineurin protein expression in right atrial appendages from patients underwent valve replacement with or without atrial fibrillation].
Hyperalgesia
Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons.
Hyperglycemia
Somatostatin protects photoreceptor cells against high glucose-induced apoptosis.
Hyperinsulinism
Euglycemic hyperinsulinemia and hyperaminoacidemia decrease skeletal muscle ubiquitin mRNA in goats.
Hypersensitivity
Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury.
Hypersensitivity
Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.
Hypertension
Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension.
Hypertension, Pulmonary
Calcium-dependent cleavage of the Na(+)/Ca(2+) exchanger by m-calpain in isolated endoplasmic reticulum.
Hypertension, Pulmonary
m-Calpain-mediated cleavage of Na(+)/Ca (2+) exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle.
Hypertension, Renovascular
Transcriptional regulation of calcium-activated neutral protease in cardiomyocytes of hypertensive rats.
Infections
Expression of calpain II gene in human hematopoietic system cells infected with human T-cell leukemia virus type I.
Inflammatory Breast Neoplasms
The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy.
Leukemia, T-Cell
Expression of calpain II gene in human hematopoietic system cells infected with human T-cell leukemia virus type I.
Leukemia-Lymphoma, Adult T-Cell
Gene expression for calpain isozymes in human hematopoietic system cells.
Leukemia-Lymphoma, Adult T-Cell
Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia.
Lung Neoplasms
Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway.
Lung Neoplasms
Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion.
Lung Neoplasms
Noninvasive Early Detection of Calpain 2-Enriched Non-Small Cell Lung Cancer Using a Human Serum Albumin-Bounded Calpain 2 Nanosensor.
Lung Neoplasms
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.
Marfan Syndrome
Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms.
Memory Disorders
Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects.
Muscle Spasticity
Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery.
Muscular Atrophy
Daily variations in dietary lysine content alter the expression of genes related to proteolysis in chicken pectoralis major muscle.
Muscular Atrophy
Gene expression of proteolytic systems and growth regulators of skeletal muscle in horses with myopathy associated with pituitary pars intermedia dysfunction.
Muscular Atrophy
Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats.
Muscular Dystrophies
Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain.
Muscular Dystrophies
Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts.
Muscular Dystrophies, Limb-Girdle
Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain.
Muscular Dystrophy, Duchenne
Altered expression, intracellular distribution and activity of lymphocyte calpain II in Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Deletion analysis & calpain status for carrier detection in a family with Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Platelet m-calpain: a facile marker and STR polymorphism analysis for the identification of true carriers of Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Quantitative ELISA for platelet m-calpain: a phenotypic index for detection of carriers of Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts.
Myocardial Infarction
Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction.
Neoplasm Metastasis
Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-?B/DNMT1 signaling pathway.
Neoplasm Metastasis
Calpains are required for invasive and metastatic potentials of human HCC cells.
Neoplasms
1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours.
Neoplasms
Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea.
Neoplasms
Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2.
Neoplasms
Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.
Neoplasms
Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment.
Neoplasms
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Neoplasms
CALPAIN activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss.
Neoplasms
Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy.
Neoplasms
Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway.
Neoplasms
Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.
Neoplasms
Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.
Neoplasms
Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme.
Neoplasms
Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury.
Neoplasms
Epigallocatechin-3-gallate pretreatment attenuates doxorubicin-induced cardiotoxicity in rats: A mechanistic study.
Neoplasms
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Neoplasms
Human U87 astrocytoma cell invasion induced by interaction of ?ig-h3 with integrin ?5?1 involves calpain-2.
Neoplasms
Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.
Neoplasms
Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis.
Neoplasms
Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-butyl-4-methylphenol (BHT) and 2-tert-butyl-4-methyl-6-iso-propylphenol: correlation with quinone methide reactivity.
Neoplasms
mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line.
Neoplasms
New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status.
Neoplasms
Noninvasive Early Detection of Calpain 2-Enriched Non-Small Cell Lung Cancer Using a Human Serum Albumin-Bounded Calpain 2 Nanosensor.
Neoplasms
Novel Bioinformatics-Based Approach for Proteomic Biomarkers Prediction of Calpain-2 &Caspase-3 Protease Fragmentation: Application to ?II-Spectrin Protein.
Neoplasms
NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene.
Neoplasms
pH-sensitive multi-drug liposomes targeting folate receptor ? for efficient treatment of non-small cell lung cancer.
Neoplasms
Strain-related differences in the pneumotoxic effects of chronically administered butylated hydroxytoluene on protein kinase C and calpain.
Neoplasms
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
Neoplasms
Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation.
Neuralgia
Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons.
Neuralgia
Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury.
Neuroblastoma
Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system.
Neuroblastoma
Differential degradation of calpastatin by mu- and m-calpain in Ca(2+)-enriched human neuroblastoma LAN-5 cells.
Neuroblastoma
Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity.
Neuroblastoma
Tauopathy-Associated Tau Fragment Ending at Amino Acid 224 Is Generated by Calpain-2 Cleavage.
Neurodegenerative Diseases
Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.
Neurodegenerative Diseases
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Neurodegenerative Diseases
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
Neuroinflammatory Diseases
Changes in activity of µ- and m-calpains and signs of neuroinflammation in the hippocampus and striatum of rats after single intraperitoneal injection of subseptic dose of endotoxin.
Osteoarthritis
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis.
Osteoarthritis
G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage.
Osteoarthritis
Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis.
Ovarian Neoplasms
Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.
Ovarian Neoplasms
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.
Pancreatic Neoplasms
The calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model.
Paralysis
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Paralysis
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
Parkinson Disease
Calpastatin immunoreactivity in the monkey and human brain of control subjects and patients with Parkinson's disease.
Parkinson Disease
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
Pneumonia
Calpeptin attenuates cigarette smoke-induced pulmonary inflammation via suppressing calpain/I?B? signaling in mice and BEAS-2B cells.
Prostatic Neoplasms
Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines.
Prostatic Neoplasms
Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-?B/DNMT1 signaling pathway.
Prostatic Neoplasms
Cleavage of beta-catenin by calpain in prostate and mammary tumor cells.
Prostatic Neoplasms
Geranylated 4-phenylcoumarins extracted from Mesua elegans induced caspase-independent cell death in prostate cancer cell lines through calpain-2 and cathepsin B.
Prostatic Neoplasms
Prolonged androgen deprivation leads to overexpression of calpain 2: implications for prostate cancer progression.
Prostatic Neoplasms
The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells.
Proteinuria
Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
Pulmonary Arterial Hypertension
Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension.
Seizures
Calpain-2 activation in mouse hippocampus plays a critical role in seizure-induced neuropathology.
Seizures
Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.
Sepsis
Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.
Sepsis
Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism.
Sepsis
Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury.
Severe Acute Respiratory Syndrome
Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain.
Small Cell Lung Carcinoma
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.
Spasm
Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats.
Spinal Cord Injuries
Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury.
Spinal Cord Ischemia
Degradation of spectrin via calpains in the ventral horn after transient spinal cord ischemia in rabbits.
Stomach Neoplasms
Artesunate inhibits the growth of gastric cancer cells through the mechanism of promoting oncosis both in vitro and in vivo.
Stomach Neoplasms
Comparison of the protein expression of calpain-1, calpain-2, calpastatin and calmodulin between gastric cancer and normal gastric mucosa.
Striatonigral Degeneration
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
Supranuclear Palsy, Progressive
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Supranuclear Palsy, Progressive
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
Tauopathies
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Tauopathies
P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein.
Tauopathies
Tauopathy-Associated Tau Fragment Ending at Amino Acid 224 Is Generated by Calpain-2 Cleavage.
Thrombosis
Inhibition of Shear-Induced Platelet Aggregation by Xueshuantong via Targeting Piezo1 Channel-Mediated Ca2+ Signaling Pathway.
Urinary Incontinence
miR-93?mediated collagen expression in stress urinary incontinence via calpain-2.
Urinary Incontinence
The role of calpain-calpastatin system in the development of stress urinary incontinence.
Wolfram Syndrome
A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.