Reference on EC 3.4.22.52 - calpain-1 and Organism(s) Homo sapiens
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
topREF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shastri, R.; Anandaraj, M.P.J.S.
A low-calcium-requiring calcium-activated neutral proteinase from human placenta
Biochim. Biophys. Acta
873
260-266
1986
Homo sapiens
Aoki, K.; Imajoh, S.; Ohno, S.; Emori, Y.; Koike, M.; Kosaki, G.; Suzuki K.
Complete amino acid sequence of the large subunit of the low-Ca2+-requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence
FEBS Lett.
205
313-317
1986
Homo sapiens (P07384), Homo sapiens
Michetti, M.; Salamino, F.; Minafra, R.; Melloni, E.; Pontremoli, S.
Calcium-binding properties of human erythrocyte calpain
Biochem. J.
325
721-726
1997
Homo sapiens
-
Vilei, E.M.; Calderara, S.; Anagli, J
Berardi, S.; Hitomi, K.; Maki, M: Carafoli, E.: Functional properties of recombinant calpain I and of mutants lacking domains III and IV of the catalytic subunits
J. Biol. Chem.
727
25802-25808
1997
Homo sapiens
-
Hitomi, K.; Uchiyama, Y.; Ohkubo, I.; Kunimatsu, M.; Sasaki, M.; Maki, M.
Purification and characterization of the active-site-mutated recombinant human mikro-calpain expressed in baculovirus-infected insect cells
Biochem. Biophys. Res. Commun.
246
681-685
1998
Homo sapiens
Shastri, R.; Jagadeesh, G.; Anandaraj, M.P.J.S.
Human placental calcium activated neutral proteinase: Separation and functional characterization of subunits
J. Biosci.
15
427-434
1990
Homo sapiens
-
Yoshimura, N.; Kikuchi, T.; Sasaki, T.; Kithara, A.; Hatanaka, M.; Murachi, T.
Two distinct Ca2+ proteases (calpain I and calpain II) purified concurrently by the same method from rat kidney
J. Biol. Chem.
258
8883-8889
1983
Homo sapiens, Rattus norvegicus
Molinari, M.; maki, M.; Carafoli, E.
Purification of mu-calpain by a novel affinity chromatography approach. New insight into the mechanism of the interaction of the protease with targets
J. Biol. Chem.
270
14576-14581
1995
Homo sapiens
Diaz, B.G.; Gross, S.; Assfalg-Machleidt, I.; Pfeiler, D.; Gollmitzer, N.; Gabrijelcic-Geiger, D.; Stubbs, M.T.; Fritz, H.; Auerswald, E.A.; Machleidt, W.
Cystatins as calpain inhibitors: engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of m-calpain
Biol. Chem.
382
97-107
2001
Homo sapiens
Shields, D.C.; Schaecher, K.E.; Saido, T.C.; Banik, N.L.
A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain
Proc. Natl. Acad. Sci. USA
96
11486-11491
1999
Homo sapiens
Wolf, B.B.; Goldstein, J.C.; Stennicke, H.R.; Beere, H.; Amarante-Mendes, G.P.; Salvesen, G.S.; Green, D.R.
Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation
Blood
94
1683-1692
1999
Homo sapiens, Sus scrofa
Tompa, P.; Toth-Boconadi, R.; Friedrich, P.
Frequency decoding of fast calcium oscillations by calpain
Cell Calcium
29
161-170
2001
Homo sapiens
Rojas, F.J.; Brush, M.; Moretti-Rojas, I.
Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa
Mol. Hum. Reprod.
5
520-526
1999
Homo sapiens
Murphy, R.M.; Snow, R.J.; Lamb, G.D.
m-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans
Am. J. Physiol.
290
C116-C122
2006
Homo sapiens
Veerann, V.; Kaji, T.; Boland, B.; Odrljin, T.; Mohan, P.; Basavarajappa, B.S.; Peterhoff, C.; Cataldo, A.; Rudnicki, A.; Amin, N.; Li, B.S.; Pant, H.C.; Hungund, B.L.; Arancio, O.; Nixon, R.A.
Calpain mediates calcium-induced activation of the Erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: Relevance to Alzheimers disease
Am. J. Pathol.
165
795-805
2004
Homo sapiens
Fernandez-Montalvan, A.; Assfalg-Machleidt, I.; Pfeiler, D.; Fritz, H.; Jochum, M.; Machleidt, W.
mu-Calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation
Biol. Chem.
387
617-627
2006
Homo sapiens
Bihovsky, R.; Tao, M.; Mallamo, J.P.; Wells, G.J.
1,2-Benzothiazine 1,1-dioxide alpha-ketoamide analogues as potent calpain I inhibitors
Bioorg. Med. Chem. Lett.
14
1035-1038
2004
Homo sapiens
Carragher, N.O.
Calpain inhibition: a therapeutic strategy targeting multiple disease states
Curr. Pharm. Des.
12
615-638
2006
Homo sapiens (P07384)
Guerini, D.; Pan, B.; Carafoli, E.
Expression, purification, and characterization of isoform 1 of the plasma membrane Ca2+ pump: focus on calpain sensitivity
J. Biol. Chem.
278
38141-38148
2003
Homo sapiens
Altznauer, F.; Conus, S.; Cavalli, A.; Folkers, G.; Simon, H.U.
Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis
J. Biol. Chem.
279
5947-5957
2004
Homo sapiens
Kumagai, K.; Ozaki, Y.; Nakanishi, T.; Inomata, M.; Furuno, T.; Nakanishi, M.; Ogasawara, M.S.
Role of mu-calpain in human decidua for recurrent miscarriage
Am. J. Reprod. Immunol.
59
339-346
2008
Homo sapiens
Morita, M.; Banno, Y.; Dohjima, T.; Nozawa, S.; Fushimi, K.; Fan, D.G.; Ohno, T.; Miyazawa, K.; Liu, N.; Shimizu, K.
mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line
Biochem. Biophys. Res. Commun.
343
937-942
2006
Homo sapiens
Govindarajan, B.; Laird, J.; Salomon, R.G.; Bhattacharya, S.K.
Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork
Biochemistry
47
817-825
2008
Homo sapiens
Berg, U.; Bang, P.; Carlsson-Skwirut, C.
Calpain proteolysis of insulin-like growth factor binding protein (IGFBP) -2 and -3, but not of IGFBP-1
Biol. Chem.
388
859-863
2007
Homo sapiens
Pfizer, J.; Assfalg-Machleidt, I.; Machleidt, W.; Schaschke, N.
Inhibition of human mu-calpain by conformationally constrained calpastatin peptides
Biol. Chem.
389
83-90
2008
Homo sapiens
Chicharro, R.; Alonso, M.; Mazo, M.T.; Aran, V.J.; Herradon, B.
Derivatives of 3-sec-butyl-1-oxo-2,3-dihydroisoquinoline as inhibitors of micro mu-calpain
ChemMedChem
1
710-714
2006
Homo sapiens, Sus scrofa
Randriamboavonjy, V.; Pistrosch, F.; Boelck, B.; Schwinger, R.H.; Dixit, M.; Badenhoop, K.; Cohen, R.A.; Busse, R.; Fleming, I.
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone
Circulation
117
52-60
2008
Homo sapiens
Wu, M.; Yu, Z.; Fan, J.; Caron, A.; Whiteway, M.; Shen, S.H.
Functional dissection of human protease mu-calpain in cell migration using RNAi
FEBS Lett.
580
3246-3256
2006
Homo sapiens
Murphy, R.M.; Goodman, C.A.; McKenna, M.J.; Bennie, J.; Leikis, M.; Lamb, G.D.
Calpain-3 is autolyzed and hence activated in human skeletal muscle 24 h following a single bout of eccentric exercise
J. Appl. Physiol.
103
926-931
2007
Homo sapiens
Xu, L.; Deng, X.
Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of micro- and m-calpains
J. Biol. Chem.
281
35567-35575
2006
Homo sapiens
Badugu, R.; Garcia, M.; Bondada, V.; Joshi, A.; Geddes, J.W.
N terminus of calpain 1 is a mitochondrial targeting sequence
J. Biol. Chem.
283
3409-3417
2008
Homo sapiens, Rattus norvegicus
Yaroslavskiy, B.B.; Sharrow, A.C.; Wells, A.; Robinson, L.J.; Blair, H.C.
Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility
J. Cell Sci.
120
2884-2894
2007
Homo sapiens
Upla, P.; Marjomaeki, V.; Nissinen, L.; Nylund, C.; Waris, M.; Hyypiae, T.; Heino, J.
Calpain 1 and 2 are required for RNA replication of echovirus 1
J. Virol.
82
1581-1590
2008
Homo sapiens
Covington, M.D.; Arrington, D.D.; Schnellmann, R.G.
Calpain 10 is required for cell viability and is decreased in the aging kidney
Am. J. Physiol. Renal Physiol.
296
F478-F486
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Vissing, K.; Overgaard, K.; Nedergaard, A.; Fredsted, A.; Schjerling, P.
Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle
Eur. J. Appl. Physiol.
103
323-332
2008
Homo sapiens (P07384), Homo sapiens
Verburg, E.; Murphy, R.M.; Richard, I.; Lamb, G.D.
Involvement of calpains in Ca2+-induced disruption of excitation-contraction coupling in mammalian skeletal muscle fibers
Am. J. Physiol. Cell Physiol.
296
C1115-C1122
2009
Homo sapiens
Sergeev, I.N.
1,25-Dihydroxyvitamin D3 induces Ca2+-mediated apoptosis in adipocytes via activation of calpain and caspase-12
Biochem. Biophys. Res. Commun.
384
18-21
2009
Homo sapiens
Hayakawa, M.; Hayakawa, H.; Matsuyama, Y.; Tamemoto, H.; Okazaki, H.; Tominaga, S.
Mature interleukin-33 is produced by calpain-mediated cleavage in vivo
Biochem. Biophys. Res. Commun.
387
218-222
2009
Homo sapiens
Jiao, W.; McDonald, D.Q.; Coxon, J.M.; Parker, E.J.
Molecular modeling studies of peptide inhibitors highlight the importance of conformational prearrangement for inhibition of calpain
Biochemistry
49
5533-5539
2010
Homo sapiens
Zhang, P.; Sridharan, D.M.; Lambert, M.W.
Knockdown of micro-calpain in Fanconi Anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair
Biochemistry
49
5570-5581
2010
Homo sapiens
Mellgren, R.L.; Miyake, K.; Kramerova, I.; Spencer, M.J.; Bourg, N.; Bartoli, M.; Richard, I.; Greer, P.A.; McNeil, P.L.
Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases
Biochim. Biophys. Acta
1793
1886-1893
2009
Homo sapiens
Kelly, J.C.; Cuerrier, D.; Graham, L.A.; Campbell, R.L.; Davies, P.L.
Profiling of calpain activity with a series of FRET-based substrates
Biochim. Biophys. Acta
1794
1505-1509
2009
Homo sapiens
Goncalves, I.; Nitulescu, M.; Saido, T.; Dias, N.; Pedro, L.; e Fernandes, J.; Ares, M.; Poern-Ares, I.
Activation of calpain-1 in human carotid artery atherosclerotic lesions
BMC Cardiovasc. Disord.
9
26
2009
Homo sapiens
Blachford, C.; Celic, A.; Petri, E.T.; Ehrlich, B.E.
Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding
Cell Calcium
46
257-262
2009
Homo sapiens
Dean, P.; Muehlen, S.; Quitard, S.; Kenny, B.
The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector
Cell. Microbiol.
12
1308-1321
2010
Homo sapiens
Murphy, R.M.
Calpains, skeletal muscle function and exercise
Clin. Exp. Pharmacol. Physiol.
37
385-391
2010
Homo sapiens, Rattus norvegicus
Pietsch, M.; Chua, K.C.; Abell, A.D.
Calpains: attractive targets for the development of synthetic inhibitors
Curr. Top. Med. Chem.
10
270-293
2010
Homo sapiens
Le Goff, E.; Vallentin, A.; Harmand, P.O.; Aldrian-Herrada, G.; Rebiere, B.; Roy, C.; Benyamin, Y.; Lebart, M.C.
Characterization of L-plastin interaction with beta integrin and its regulation by micro-calpain
Cytoskeleton (Hoboken)
67
286-296
2010
Homo sapiens
Roumes, H.; Leloup, L.; Dargelos, E.; Brustis, J.J.; Daury, L.; Cottin, P.
Calpains: markers of tumor aggressiveness?
Exp. Cell Res.
316
1587-1599
2010
Homo sapiens
Ravulapalli, R.; Campbell, R.L.; Gauthier, S.Y.; Dhe-Paganon, S.; Davies, P.L.
Distinguishing between calpain heterodimerization and homodimerization
FEBS J.
276
973-982
2009
Homo sapiens
Simonin, Y.; Disson, O.; Lerat, H.; Antoine, E.; Biname, F.; Rosenberg, A.R.; Desagher, S.; Lassus, P.; Bioulac-Sage, P.; Hibner, U.
Calpain activation by hepatitis C virus proteins inhibits the extrinsic apoptotic signaling pathway
Hepatology
50
1370-1379
2009
Homo sapiens
Martin-Villar, E.; Yurrita, M.M.; Fernandez-Munoz, B.; Quintanilla, M.; Renart, J.
Regulation of podoplanin/PA2.26 antigen expression in tumour cells. Involvement of calpain-mediated proteolysis
Int. J. Biochem. Cell Biol.
41
1421-1429
2009
Homo sapiens
Liu, L.; Xing, D.; Chen, W.R.
Micro-calpain regulates caspase-dependent and apoptosis inducing factor-mediated caspase-independent apoptotic pathways in cisplatin-induced apoptosis
Int. J. Cancer
125
2757-2766
2009
Homo sapiens
Wu, Y.; Zhang, L.; Jin, H.; Zhou, J.; Xie, Z.
The role of calpain-calpastatin system in the development of stress urinary incontinence
Int. Urogynecol. J. Pelvic. Floor Dysfunct.
21
63-68
2010
Homo sapiens
Lehti, M.; Kivelae, R.; Komi, P.; Komulainen, J.; Kainulainen, H.; Kyroelaeinen, H.
Effects of fatiguing jumping exercise on mRNA expression of titin-complex proteins and calpains
J. Appl. Physiol.
106
1419-1424
2009
Homo sapiens
Gafni, J.; Cong, X.; Chen, S.F.; Gibson, B.W.; Ellerby, L.M.
Calpain-1 cleaves and activates caspase-7
J. Biol. Chem.
284
25441-25449
2009
Homo sapiens
OConnell, M.P.; Fiori, J.L.; Baugher, K.M.; Indig, F.E.; French, A.D.; Camilli, T.C.; Frank, B.P.; Earley, R.; Hoek, K.S.; Hasskamp, J.H.; Elias, E.G.; Taub, D.D.; Bernier, M.; Weeraratna, A.T.
Wnt5A activates the calpain-mediated cleavage of filamin A
J. Invest. Dermatol.
129
1782-1789
2009
Homo sapiens
Kang, D.H.; Jun, K.Y.; Lee, J.P.; Pak, C.S.; Na, Y.; Kwon, Y.
Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity
J. Med. Chem.
52
3093-3097
2009
Homo sapiens
Averna, M.; Stifanese, R.; De Tullio, R.; Beccaria, F.; Salamino, F.; Pontremoli, S.; Melloni, E.
Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells
J. Neurochem.
110
412-421
2009
Homo sapiens
Wang, Y.; Kim, N.S.; Li, X.; Greer, P.A.; Koehler, R.C.; Dawson, V.L.; Dawson, T.M.
Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)
J. Neurochem.
110
687-696
2009
Homo sapiens
Xu, J.; Kurup, P.; Zhang, Y.; Goebel-Goody, S.M.; Wu, P.H.; Hawasli, A.H.; Baum, M.L.; Bibb, J.A.; Lombroso, P.J.
Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP
J. Neurosci.
29
9330-9343
2009
Homo sapiens
Zadran, S.; Jourdi, H.; Rostamiani, K.; Qin, Q.; Bi, X.; Baudry, M.
Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation
J. Neurosci.
30
1086-1095
2010
Homo sapiens
Ma, H.; Tochigi, A.; Shearer, T.R.; Azuma, M.
Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells
J. Ocul. Pharmacol. Ther.
25
409-414
2009
Homo sapiens
Alonso, M.; Chicharro, R.; Miranda, C.; Aran, V.J.; Maestro, M.A.; Herradon, B.
X-ray diffraction, solution structure, and computational studies on derivatives of (3-sec-butyl-2,3-dihydro-1H-isoquinolin-4-ylidene)acetic acid: compounds with activity as calpain inhibitors
J. Org. Chem.
75
342-352
2010
Homo sapiens
Rudic, B.; Song, H.; Breedijk, A.; Brinkkoetter, P.; Beck, G.; Yard, B.; Ponelies, N.
Hypothermic preservation up-regulates calpain expression and increases ubiquitination in cultured vascular endothelial cells: influence of dopamine pretreatment
J. Surg. Res.
160
325-332
2010
Homo sapiens
Esteves, A.R.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.
Dysfunctional mitochondria uphold calpain activation: contribution to Parkinsons disease pathology
Neurobiol. Dis.
37
723-730
2010
Homo sapiens
Kulkarni, S.; Reddy, K.B.; Esteva, F.J.; Moore, H.C.; Budd, G.T.; Tubbs, R.R.
Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer
Oncogene
29
1339-1350
2010
Homo sapiens
Chandramohanadas, R.; Davis, P.H.; Beiting, D.P.; Harbut, M.B.; Darling, C.; Velmourougane, G.; Lee, M.Y.; Greer, P.A.; Roos, D.S.; Greenbaum, D.C.
Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells
Science
324
794-797
2009
Homo sapiens
Kim, D.S.; Han, B.G.; Park, K.S.; Lee, B.I.; Kim, S.Y.; Bae, C.D.
I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway
Biochem. Biophys. Res. Commun.
399
300-306
2010
Homo sapiens
Panigrahi, A.K.; Zhang, N.; Mao, Q.; Pati, D.
Calpain-1 cleaves Rad21 to promote sister chromatid separation
Mol. Cell. Biol.
31
4335-4347
2011
Homo sapiens
Prangsaengtong, O.; Senda, K.; Doki, Y.; Park, J.Y.; Jo, M.; Sakurai, H.; Shibahara, N.; Saiki, I.; Koizumi, K.
Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation
Hum. Cell
25
36-44
2012
Homo sapiens
Averna, M.; De Tullio, R.; Pedrazzi, M.; Bavestrello, M.; Pellegrini, M.; Salamino, F.; Pontremoli, S.; Melloni, E.
Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease
PLoS ONE
10
e0116738
2015
Homo sapiens
Fan, X.; Zhang, Q.; You, C.; Qian, Y.; Gao, J.; Liu, P.; Chen, H.; Song, H.; Chen, Y.; Chen, K.; Zhou, Y.
Proteolysis of the human DNA polymerase delta smallest subunit p12 by mu-calpain in calcium-triggered apoptotic HeLa cells
PLoS ONE
9
e93642
2014
Homo sapiens
Jiang, S.; Shao, C.; Tang, F.; Wang, W.; Zhu, X.
Dynamin-like protein 1 cleavage by calpain in Alzheimers disease
Aging Cell
18
e12912
2019
Homo sapiens (P07384)
Campbell, J.S.; Hallett, M.B.
Active calpain in phagocytically competent human neutrophils electroinjection of fluorogenic calpain substrate
Biochem. Biophys. Res. Commun.
457
341-346
2015
Homo sapiens (P07384), Homo sapiens
Chen, Q.; Lesnefsky, E.J.
Heart mitochondria and calpain 1 Location, function, and targets
Biochim. Biophys. Acta
1852
2372-2378
2015
Homo sapiens (P07384)
Jantos, K.; Kling, A.; Mack, H.; Hornberger, W.; Moeller, A.; Nimmrich, V.; Lao, Y.; Nijsen, M.
Discovery of ABT-957 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability
Bioorg. Med. Chem. Lett.
29
1968-1973
2019
Homo sapiens (P07384)
