Disease on EC 3.4.22.52 - calpain-1 and Organism(s) Homo sapiens
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Acute Kidney Injury
Perspective on rhabdomyolysis-induced acute kidney injury and new treatment options.
Adenocarcinoma
Calpain 1 in bronchoalveolar lavage fluid is associated with poor prognosis in lepidic predominant pulmonary adenocarcinoma.
Adenocarcinoma
Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas.
Adenocarcinoma of Lung
Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling.
Adenocarcinoma of Lung
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Adenocarcinoma of Lung
mu-Calpain regulates caspase-dependent and apoptosis inducing factor-mediated caspase-independent apoptotic pathways in cisplatin-induced apoptosis.
Alzheimer Disease
Accumulation of ?-synuclein in dementia with Lewy bodies is associated with decline in the ?-synuclein-degrading enzymes kallikrein-6 and calpain-1.
Alzheimer Disease
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.
Alzheimer Disease
An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq.
Alzheimer Disease
Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease.
Alzheimer Disease
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Alzheimer Disease
Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain.
Alzheimer Disease
Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer's Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain.
Alzheimer Disease
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.
Alzheimer Disease
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives.
Alzheimer Disease
Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.
Alzheimer Disease
Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma.
Alzheimer Disease
Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease.
Alzheimer Disease
Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies.
Alzheimer Disease
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
Alzheimer Disease
Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain.
Alzheimer Disease
Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.
Alzheimer Disease
Truncation and activation of GSK-3? by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease.
Alzheimer Disease
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.
Amyotrophic Lateral Sclerosis
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases.
Anemia, Sickle Cell
Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology.
Anemia, Sickle Cell
Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Anemia, Sickle Cell
Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease.
Anemia, Sickle Cell
Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease.
Aneurysm
The role of extracellular and intracellular proteolytic systems in aneurysms of the ascending aorta.
Aortic Aneurysm
The role of extracellular and intracellular proteolytic systems in aneurysms of the ascending aorta.
Aortic Aneurysm, Abdominal
Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice.
Arsenic Poisoning
[Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25].
Arthralgia
Intracellular versus extracellular inhibition of calpain I causes differential effects on pain in a rat model of joint inflammation.
Arthritis, Rheumatoid
An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq.
Arthritis, Rheumatoid
Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future?
Arthritis, Rheumatoid
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis.
Ataxia
A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds.
Ataxia
CAPN1 mutations broadening the hereditary spastic paraplegia/spinocerebellar ataxia phenotype.
Ataxia
CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia.
Ataxia
Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.
Ataxia
Increasing involvement of CAPN1 variants in spastic ataxias and phenotype-genotype correlations.
Ataxia
Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed.
Ataxia
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases.
Ataxia
Novel CAPN1 mutations extend the phenotypic heterogeneity in combined spastic paraplegia and ataxia.
Ataxia
Two novel homozygous mutations of CAPN1 in Chinese patients with hereditary spastic paraplegia and literatures review.
Ataxia Telangiectasia
The expression of genes related to adipocyte differentiation in pigs.
Atherosclerosis
Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis.
Atherosclerosis
Downregulations of CD36 and Calpain-1, Inflammation, and Atherosclerosis by Simvastatin in Apolipoprotein E Knockout Mice.
Atherosclerosis
Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.
Atrial Fibrillation
Calpain I inhibition prevents atrial structural remodeling in a canine model with atrial fibrillation.
Atrial Fibrillation
[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine]
Atrial Fibrillation
[Calpain-I, calpastatin, caspase-3 and apoptosis in the human left atrium in rheumatic atrial fibrillation]
Atrial Fibrillation
[Effect of calpain 1 on structural remodeling and contractile dysfunction in atrial fibrillation: experiment with dogs]
Atrial Fibrillation
[Influence of oxidative stress on atrial myocardium pathohistological and ultrastructural changes in atrial fibrillation: experiment with dogs]
Blindness
Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury.
Blister
Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis.
Bone Resorption
A high fat diet-induced impaired glucose metabolism in mice with targeted deletion of calpain in osteoblasts.
Brain Diseases
Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer's Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain.
Brain Injuries
mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury.
Brain Injuries
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study.
Brain Injuries, Traumatic
A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat.
Brain Injuries, Traumatic
Alpha II Spectrin breakdown products in immature Sprague Dawley rat hippocampus and cortex after traumatic brain injury.
Brain Injuries, Traumatic
Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA.
Brain Injuries, Traumatic
Casein zymogram assessment of mu-calpain and m-calpain activity after traumatic brain injury in the rat in vivo.
Brain Injuries, Traumatic
Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats.
Brain Injuries, Traumatic
mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury.
Brain Injuries, Traumatic
pH dependency of mu-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat.
Brain Injuries, Traumatic
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study.
Brain Injuries, Traumatic
Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
Brain Ischemia
20(R)-Ginsenoside Rg3 protects SH-SY5Y cells against apoptosis induced by oxygen and glucose deprivation/reperfusion.
Brain Ischemia
Calpain mediates eukaryotic initiation factor 4G degradation during global brain ischemia.
Brain Ischemia
Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia.
Brain Ischemia
Exploration of the importance of the P2-P3-NHCO-moiety in a potent di- or tripeptide inhibitor of calpain I: insights into the development of nonpeptidic inhibitors of calpain I.
Brain Ischemia
Ischemia-induced modifications of protein components of rat brain postsynaptic densities.
Brain Ischemia
Neurovascular and neuronal protection by E64d after focal cerebral ischemia in rats.
Brain Ischemia
Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity.
Brain Ischemia
Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors.
Brain Ischemia
RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia.
Brain Ischemia
Synergetic Effects of Caspase 3 and mu-Calpain in XIAP-Breakdown upon Focal Cerebral Ischemia.
Breast Neoplasms
Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis.
Breast Neoplasms
Calpain system protein expression in basal-like and triple-negative invasive breast cancer.
Breast Neoplasms
Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy.
Breast Neoplasms
Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study.
Breast Neoplasms
Cleavage and activation of LIM kinase 1 as a novel mechanism for calpain 2-mediated regulation of nuclear dynamics.
Breast Neoplasms
Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain.
Breast Neoplasms
Effects of ARHI on cell cycle progression and apoptosis levels of breast cancer cells.
Breast Neoplasms
Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis.
Breast Neoplasms
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Breast Neoplasms
Genistein induces Ca2+ -mediated, calpain/caspase-12-dependent apoptosis in breast cancer cells.
Breast Neoplasms
Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer.
Breast Neoplasms
Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer.
Breast Neoplasms
The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy.
Breast Neoplasms
The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study.
Breast Neoplasms
Type V collagen-induced upregulation of capn2 (large subunit of m-calpain) gene expression and DNA fragmentation in 8701-BC breast cancer cells.
calpain-1 deficiency
Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia.
calpain-2 deficiency
Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.
Carcinogenesis
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Carcinogenesis
miR-124 Intensified Oxaliplatin-Based Chemotherapy by Targeting CAPN2 in Colorectal Cancer.
Carcinoma
1,25-Dihydroxyvitamin D3 increases the cellular content of the calcium-activated neutral protease mu-calpain in renal cell carcinoma.
Carcinoma
A comparison of the intracellular distribution of mu-calpain, m-calpain, and calpastatin in proliferating human A431 cells.
Carcinoma
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Carcinoma
Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.
Carcinoma
Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma.
Carcinoma
Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type.
Carcinoma
High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma.
Carcinoma
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.
Carcinoma
Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma.
Carcinoma
Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma.
Carcinoma, Hepatocellular
Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network.
Carcinoma, Hepatocellular
Interference with Ca(2+)-Dependent Proteolysis Does Not Alter the Course of Muscle Wasting in Experimental Cancer Cachexia.
Carcinoma, Renal Cell
1,25-Dihydroxyvitamin D3 increases the cellular content of the calcium-activated neutral protease mu-calpain in renal cell carcinoma.
Carcinoma, Renal Cell
Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type.
Carcinoma, Renal Cell
Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma.
Carcinoma, Renal Cell
Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma.
Cardiomegaly
Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction.
Cardiomegaly
Early dystrophin loss is coincident with the transition of compensated cardiac hypertrophy to heart failure.
Cardiomegaly
Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain-1 expression and inhibits NF-?B activation in streptozotocin-induced diabetic rats.
Cardiomegaly
Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats.
Cardiomegaly
[Role of valsartan on myocardial Calpain I, calcineurin and Ca/calmodulin-dependent protein kinase II? expression of renovascular hypertensive rats].
Cardiomyopathies
[Effect of valsartan and carnitine on cardiomyocyte Calpain-1 and Bcl-xl expressions of dogs with chronic alcohol intake-induced cardiomyopathy].
Cardiomyopathy, Alcoholic
Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy.
Cardiotoxicity
Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways.
Cardiovascular Diseases
Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats.
Cataract
Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse.
Cataract
alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract.
Cataract
Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64.
Cataract
Changes in calpain II mRNA in young rat lens during maturation and cataract formation.
Cataract
Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses.
Cataract
Hydration and elevated calcium alone do not produce xylose nuclear cataract: role of proteolysis by calpain.
Cataract
In vitro precipitation of rat lens crystallins by calpain I--a calpain requiring low amounts of calcium for activation.
Cataract
Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains.
Cerebellar Ataxia
A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family.
Cerebellar Ataxia
Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.
Cerebellar Ataxia
Novel CAPN1 mutations extend the phenotypic heterogeneity in combined spastic paraplegia and ataxia.
Cholecystitis
Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma.
Coinfection
Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system.
Colitis
Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/ROR?/NF-?B signaling pathways.
Colorectal Neoplasms
miR-124 Intensified Oxaliplatin-Based Chemotherapy by Targeting CAPN2 in Colorectal Cancer.
Cystic Fibrosis
Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis.
Cystic Fibrosis
Genome-wide association study for poor sperm motility in Holstein-Friesian bulls.
Dehydration
Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease.
Dementia
Accumulation of ?-synuclein in dementia with Lewy bodies is associated with decline in the ?-synuclein-degrading enzymes kallikrein-6 and calpain-1.
Dementia, Vascular
Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma.
Diabetes Mellitus
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone.
Diabetes Mellitus, Type 2
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone.
Diabetic Cardiomyopathies
Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.
Dyskinesias
The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson?s disease therapy.
Endometrial Neoplasms
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in endometrial cancer.
Endotoxemia
Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.
Epilepsy
[Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models].
Essential Hypertension
Normal erythrocyte calpain I activity on membrane proteins under near-physiological conditions in patients with essential hypertension.
Fanconi Anemia
Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair.
Frontotemporal Dementia
FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion.
Glaucoma
Neuroprotection in glaucoma using calpain-1 inhibitors: regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therapeutics.
Glioblastoma
A positive feedback loop involving nuclear factor IB and calpain 1 suppresses glioblastoma cell migration.
Glucose Intolerance
Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress.
Heart Arrest
Calpain mediates eukaryotic initiation factor 4G degradation during global brain ischemia.
Heart Diseases
Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.
Heart Failure
Calpain-2 Specifically Cleaves Junctophilin-2 at the Same Site as Calpain-1 but with Less Efficacy.
Heart Failure
Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.
Heart Failure
Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury.
Herpes Simplex
Calcium-signal facilitates herpes simplex virus type 1 nuclear transport through slingshot 1 and calpain-1 activation.
Herpes Simplex
ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+.
Huntington Disease
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.
Hyperalgesia
Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons.
Hyperalgesia
Intracellular versus extracellular inhibition of calpain I causes differential effects on pain in a rat model of joint inflammation.
Hyperglycemia
Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain.
Hyperglycemia
Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes.
Hyperglycemia
The Abnormal Architecture of Healed Diabetic Ulcers Is the Result of FAK Degradation by Calpain 1.
Hypertension
Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Hypertension
Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis.
Hypertension
Normal erythrocyte calpain I activity on membrane proteins under near-physiological conditions in patients with essential hypertension.
Hypertension
Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats.
Hypertension, Pulmonary
Identification of calpastatin and micro-calpain and studies of their association in pulmonary smooth muscle mitochondria.
Hypertension, Renovascular
Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats.
Ichthyosis, Lamellar
The calcium-activated neutral protease calpain I is present in normal foetal skin and is decreased in neonatal harlequin ichthyosis.
Infarction, Middle Cerebral Artery
Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1.
Infections
Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system.
Infections
CD163?SRCR5 MARC-145 Cells Resist PRRSV-2 Infection via Inhibiting Virus Uncoating, Which Requires the Interaction of CD163 With Calpain 1.
Infections
Degradation of p21cip1 in cells productively infected with human cytomegalovirus.
Infections
TGF-? Pathway Inhibition Protects the Diaphragm From Sepsis-Induced Wasting and Weakness in Rat.
Infections
TGF-? Pathway Inhibition Protectsthe Diaphragm From Sepsis-Induced Wasting and Weakness in Rat.
Inflammatory Breast Neoplasms
The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy.
Ischemic Stroke
Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma.
Kidney Calculi
Characterizations of HSP90-Interacting Complex in Renal Cells Using Tandem Affinity Purification and Its Potential Role in Kidney Stone Formation.
Leishmaniasis
Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania.
Leukemia
Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia.
Leukemia
Neutrophil chemotactic N-acetyl peptides from the calpain small subunit are also chemotactic for immunocytes.
Leukemia, Myeloid, Acute
A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes.
Leukemia, Myeloid, Acute
[Beta-carotene regulates the expression of proapoptotic BAX and CAPN2 in HL-60, U-937 and TF-1 - human acute myeloid leukemia cell lines; microarray, RQ-PCR and Western Blot analysis].
Leukemia, Neutrophilic, Chronic
Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia.
Liver Diseases
Knockout of calpain-1 protects against high-fat diet-induced liver dysfunction in mouse through inhibiting oxidative stress and inflammation.
Lung Injury
Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis.
Lung Neoplasms
Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling.
Lymphatic Metastasis
Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type.
Lymphoma
Induction of apoptosis in E?-myc lymphoma cells in vitro and in vivo through calpain inhibition.
Machado-Joseph Disease
Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease.
Malaria, Cerebral
Proteolytic breakdown of cytoskeleton induces neurodegeneration during pathology of murine cerebral malaria.
Melanoma
CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Melanoma
Correction: CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Melanoma
Tamoxifen enhances the cytotoxic effects of the nitrosourea fotemustine. Results on human melanoma cell lines.
Melanoma
[Tamoxifen increases cytotoxic effects of fotemustine. Experimental results on cell lines of human melanoma]
Meningioma
Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis of tumorigenesis.
Meningioma
Molecular alterations in the neurofibromatosis type 2 gene and its protein rarely occurring in meningothelial meningiomas.
Meningioma
Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas.
Multiple Endocrine Neoplasia
A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13.
Multiple Endocrine Neoplasia
Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.
Multiple Endocrine Neoplasia Type 1
A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13.
Multiple Endocrine Neoplasia Type 1
Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.
Multiple System Atrophy
Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of ?-synuclein in multiple system atrophy.
Muscle Spasticity
CAPN1 mutations broadening the hereditary spastic paraplegia/spinocerebellar ataxia phenotype.
Muscle Spasticity
CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia.
Muscle Spasticity
Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery.
Muscle Spasticity
Increasing involvement of CAPN1 variants in spastic ataxias and phenotype-genotype correlations.
Muscle Spasticity
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases.
Muscular Atrophy
A semiautomated measurement of muscle fiber size using the Imaris software.
Muscular Atrophy
Differential activation of the calpain system involved in individualized adaptation of different fast-twitch muscles in hibernating Daurian ground squirrels.
Muscular Atrophy
Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats.
Muscular Dystrophies
Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy.
Myalgia
A post-transcriptional mechanism regulates calpastatin expression in bovine skeletal muscle.
Myalgia
Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate Ingestion on Muscle Damage after Eccentric Exercise in Healthy Males: A Pilot Placebo-Controlled Double-Blind Crossover Study.
Myalgia
Effects of duration of vitamin C supplementation during the finishing period on postmortem protein degradation, tenderness, and meat color of the longissimus muscle of calf-fed steers consuming a 0.31 or 0.59% sulfur diet.
Myalgia
[Study on correlation between single nucleotide polymorphism of CAPN1 gene and muscle tenderness and carcass traits in chicken]
Myocardial Infarction
Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction.
Myocardial Ischemia
Selective Deletion of the NH(2)-Terminal Variable Region of Cardiac Troponin T in Ischemia Reperfusion by Myofibril-Associated mu-Calpain Cleavage.
Myocardial Stunning
Role of troponin I proteolysis in the pathogenesis of stunned myocardium.
Neoplasm Metastasis
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Neoplasm Metastasis
Capn4 regulates migration and invasion of ovarian carcinoma cells via targeting osteopontin-mediated PI3K/AKT signaling pathway.
Neoplasm Metastasis
Establishment, characterization, and response to cytotoxic and radiation treatment of three human melanoma cell lines.
Neoplasm Metastasis
Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type.
Neoplasm Metastasis
High calpain-1 expression predicts a poor clinical outcome and contributes to tumor progression in pancreatic cancer patients.
Neoplasm Metastasis
miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver.
Neoplasm Metastasis
Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma.
Neoplasm Metastasis
Proteomics study of serum exosomes from papillary thyroid cancer patients.
Neoplasm Metastasis
Relationship between the mRNA Expression Levels of Calpains 1/2 and Proteins Involved in Cytoskeleton Remodeling.
Neoplasm Metastasis
STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
Neoplasms
A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13.
Neoplasms
An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq.
Neoplasms
Association of mitochondrial calpain activation with increased expression and autolysis of calpain small subunit in an early stage of apoptosis.
Neoplasms
Calpain 1 in bronchoalveolar lavage fluid is associated with poor prognosis in lepidic predominant pulmonary adenocarcinoma.
Neoplasms
Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer.
Neoplasms
Calpain system protein expression in basal-like and triple-negative invasive breast cancer.
Neoplasms
Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the Proliferative/Apoptotic Index.
Neoplasms
Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy.
Neoplasms
CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Neoplasms
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Neoplasms
Capn4 regulates migration and invasion of ovarian carcinoma cells via targeting osteopontin-mediated PI3K/AKT signaling pathway.
Neoplasms
Chronic administration of UK-114, a multifunctional emerging protein, modulates the Th1/Th2 cytokine pattern and experimental autoimmune diseases.
Neoplasms
Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma.
Neoplasms
Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics.
Neoplasms
Correction: CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Neoplasms
Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding.
Neoplasms
Establishment, characterization, and response to cytotoxic and radiation treatment of three human melanoma cell lines.
Neoplasms
Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type.
Neoplasms
Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas.
Neoplasms
Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.
Neoplasms
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Neoplasms
Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.
Neoplasms
High calpain-1 expression predicts a poor clinical outcome and contributes to tumor progression in pancreatic cancer patients.
Neoplasms
High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma.
Neoplasms
Hydrolytic and autolytic behavior of two forms of calcium-activated neutral protease (CANP).
Neoplasms
I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway.
Neoplasms
Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer.
Neoplasms
LIPH promotes metastasis by enriching stem-like cells in triple-negative breast cancer.
Neoplasms
Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain-1 expression and inhibits NF-?B activation in streptozotocin-induced diabetic rats.
Neoplasms
Microarray and pattern miner analysis of AXL and VIM gene networks in MDA?MB?231 cells.
Neoplasms
miR-124 Intensified Oxaliplatin-Based Chemotherapy by Targeting CAPN2 in Colorectal Cancer.
Neoplasms
mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line.
Neoplasms
Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma.
Neoplasms
Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma.
Neoplasms
pH-sensitive multi-drug liposomes targeting folate receptor ? for efficient treatment of non-small cell lung cancer.
Neoplasms
Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes.
Neoplasms
Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer.
Neoplasms
Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor-?B (NF-?B).
Neoplasms
The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study.
Neoplasms
Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells.
Neoplasms, Squamous Cell
NF-Kappa-B downregulation strategies in head and neck cancer treatment.
Nervous System Diseases
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.
Nervous System Diseases
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives.
Neurilemmoma
Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas.
Neuroblastoma
Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system.
Neuroblastoma
Mitochondrial mu-calpain is not involved in the processing of apoptosis-inducing factor.
Neuroblastoma
Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity.
Neuroblastoma
Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex.
Neurodegenerative Diseases
Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis.
Neurodegenerative Diseases
Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors.
Neurodegenerative Diseases
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases.
Neurodegenerative Diseases
Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
Neurologic Manifestations
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Neuromuscular Diseases
Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy.
Osteoarthritis
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis.
Osteosarcoma
Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin.
Ovarian Neoplasms
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.
Pancreatic Neoplasms
High calpain-1 expression predicts a poor clinical outcome and contributes to tumor progression in pancreatic cancer patients.
Pancreatic Neoplasms
The calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model.
Pancreatitis
Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis.
Paraparesis, Spastic
CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia.
Paraplegia
CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia.
Paraplegia
Increasing involvement of CAPN1 variants in spastic ataxias and phenotype-genotype correlations.
Paraplegia
Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy.
Paraplegia
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases.
Paraplegia
Novel CAPN1 mutations extend the phenotypic heterogeneity in combined spastic paraplegia and ataxia.
Paraplegia
Two novel homozygous mutations of CAPN1 in Chinese patients with hereditary spastic paraplegia and literatures review.
Parkinson Disease
Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease.
Parkinson Disease
Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology.
Parkinson Disease
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases.
Peripheral Nervous System Diseases
Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding.
Pleural Effusion, Malignant
Calpain and spectrin breakdown products as potential biomarkers in tuberculous pleural effusion.
Prostatic Neoplasms
Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway.
Proteinuria
Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
Psoriasis
Human S100A7 Induces Mature Interleukin1? Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis.
Pulmonary Arterial Hypertension
Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Reperfusion Injury
Neuregulin-1? Plays a Neuroprotective Role by Inhibiting the Cdk5 Signaling Pathway after Cerebral Ischemia-Reperfusion Injury in Rats.
Reperfusion Injury
Neuroprotective effect of 20(R)-ginsenoside Rg(3) against transient focal cerebral ischemia in rats.
Retinitis
Evidence for the involvement of interleukin-1? during development of experimental cytomegalovirus retinitis in immunosuppressed mice.
Rheumatic Heart Disease
[Calpain-I, calpastatin, caspase-3 and apoptosis in the human left atrium in rheumatic atrial fibrillation]
Seizures
Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.
Seizures
[Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models].
Sepsis
Activation of Both the Calpain and Ubiquitin-Proteasome Systems Contributes to Septic Cardiomyopathy through Dystrophin Loss/Disruption and mTOR Inhibition.
Sepsis
Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats.
Sepsis
Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis.
Sepsis
Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism.
Sepsis
Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury.
Sepsis
TGF-? Pathway Inhibition Protects the Diaphragm From Sepsis-Induced Wasting and Weakness in Rat.
Spastic Paraplegia, Hereditary
A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family.
Spastic Paraplegia, Hereditary
A Novel Homozygous CAPN1 Pathogenic Variant in a Chinese Patient with Pure Hereditary Spastic Paraplegia.
Spastic Paraplegia, Hereditary
CAPN1 and hereditary spastic paraplegia: a novel variant in an Iranian family and overview of the genotype-phenotype correlation.
Spastic Paraplegia, Hereditary
CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia.
Spastic Paraplegia, Hereditary
CAPN1 Variants as Cause of Hereditary Spastic Paraplegia Type 76.
Spastic Paraplegia, Hereditary
Clinical aspects of hereditary spastic paraplegia 76 and novel CAPN1 mutations.
Spastic Paraplegia, Hereditary
Generation of an integration-free induced pluripotent stem cell line, FJMUi001-A, from a hereditary spastic paraplegia patient carrying compound heterozygous p.P498L and p.R618W mutations in CAPN1 (SPG76).
Spastic Paraplegia, Hereditary
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases.
Spastic Paraplegia, Hereditary
Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia.
Spastic Paraplegia, Hereditary
Novel CAPN1 mutations extend the phenotypic heterogeneity in combined spastic paraplegia and ataxia.
Spastic Paraplegia, Hereditary
Two novel homozygous mutations of CAPN1 in Chinese patients with hereditary spastic paraplegia and literatures review.
Spermatic Cord Torsion
Involvement of calpain for apoptosis in dysfunction of the unaffected testis in rats with experimental testicular torsion.
Spinal Cord Injuries
Calpain 1 Knockdown Improves Tissue Sparing and Functional Outcomes after Spinal Cord Injury in Rats.
Spinal Cord Injuries
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Spinal Cord Injuries
Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury.
Spinal Cord Injuries
Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment.
Spinal Cord Ischemia
Degradation of spectrin via calpains in the ventral horn after transient spinal cord ischemia in rabbits.
Spinocerebellar Ataxias
A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family.
Spinocerebellar Ataxias
Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.
Spinocerebellar Ataxias
Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed.
Spinocerebellar Ataxias
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases.
Squamous Cell Carcinoma of Head and Neck
Expression of Genes Encoding Cell Motility Proteins during Progression of Head and Neck Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma.
Starvation
Amino acid starvation induced autophagic cell death in PC-12 cells: evidence for activation of caspase-3 but not calpain-1.
Starvation
Identification and molecular characterization of the rainbow trout calpains (Capn1 and Capn2): their expression in muscle wasting during starvation.
Starvation
New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status.
Status Epilepticus
Calpain I Activity and Its Relationship with Hippocampal Neuronal Death in Pilocarpine-Induced Status Epilepticus Rat Model.
Status Epilepticus
Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus.
Status Epilepticus
Participation of mu-calpain in status epilepticus-induced hippocampal injury.
Stomach Neoplasms
Comparison of the protein expression of calpain-1, calpain-2, calpastatin and calmodulin between gastric cancer and normal gastric mucosa.
Stomach Neoplasms
Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis.
Stomach Neoplasms
MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1.
Stomach Neoplasms
Promotive effect of Talin-1 protein on gastric cancer progression through PTK2-PXN-VCL-E-Cadherin-CAPN2-MAPK1 signaling axis.
Stomach Neoplasms
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
Stroke
Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1.
Stroke
Synthesis and biological activity of a series of potent fluoromethyl ketone inhibitors of recombinant human calpain I.
Synovitis
Intracellular versus extracellular inhibition of calpain I causes differential effects on pain in a rat model of joint inflammation.
Synucleinopathies
Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation.
Synucleinopathies
Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro.
Tauopathies
?-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice.
Triple Negative Breast Neoplasms
Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the Proliferative/Apoptotic Index.
Triple Negative Breast Neoplasms
Cisplatin Induces Apoptosis Through the Endoplasmic Reticulum-mediated, Calpain 1 Pathway in Triple-negative Breast Cancer Cells.
Triple Negative Breast Neoplasms
The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study.
Tuberculosis, Pleural
Calpain and spectrin breakdown products as potential biomarkers in tuberculous pleural effusion.
Urinary Incontinence
The role of calpain-calpastatin system in the development of stress urinary incontinence.
Vascular Calcification
Calpain-1 Mediated Disorder of Pyrophosphate Metabolism Contributes to Vascular Calcification Induced by oxLDL.
Vascular Calcification
Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis.