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Disease on EC 3.4.22.32 - Stem bromelain

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acne Vulgaris
Applications of bromelain from pineapple waste towards acne.
Acquired Immunodeficiency Syndrome
The role of enzyme supplementation in digestive disorders.
Alveolar Bone Loss
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Alzheimer Disease
Bromelain degrades A?1-42 monomers and soluble aggregates: an in vitro study in cerebrospinal fluid of Alzheimer's disease patients.
Anaphylaxis
Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy.
Angina Pectoris
Bromelain: biochemistry, pharmacology and medical use.
Properties and therapeutic application of bromelain: a review.
Arthralgia
A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain.
Arthritis
Proteinase activity and stability of natural bromelain preparations.
Arthritis, Rheumatoid
Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults.
Exploration of bromelain laden nanostructured lipid carriers: An oral platform for bromelain delivery in rheumatoid arthritis management.
Prevention of murine EAE by oral hydrolytic enzyme treatment.
Asthma
Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure.
Asthma caused by bromelain: an occupational allergy.
Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.
Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells.
Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma.
Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma.
[Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]
Autoimmune Diseases
In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans.
Prevention of murine EAE by oral hydrolytic enzyme treatment.
Babesiosis
The effect of age on the infection and immunoresponsiveness of mice to Babesia microti.
Bacterial Infections
[Simultaneous therapy of inflammation and bacterial infection. Proteolytic activity of the saliva after administration of bromelain]
Breast Neoplasms
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma.
Bromelain Enhances the Anti-tumor Effects of Cisplatin on 4T1 Breast Tumor Model In Vivo.
Bromelain proteinase-f9 augments human lymphocyte-mediated growth-inhibition of various tumor-cells in-vitro.
Bromelain-Functionalized Multiple-Wall Lipid-Core Nanocapsules: Formulation, Chemical Structure and Antiproliferative Effect Against Human Breast Cancer Cells (MCF-7).
Bromelain-Induced Apoptosis in GI-101A Breast Cancer Cells.
Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro.
Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients.
Evaluation of the Radiosensitizing Potency of Bromelain for Radiation Therapy of 4T1 Breast Cancer Cells.
Gene expression analysis in mcf-7 breast cancer cells treated with recombinant bromelain.
Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells.
Bronchitis
Bromelain: biochemistry, pharmacology and medical use.
Polypeptides of the surface projections and the ribonucleoprotein of avian infectious bronchitis virus.
Properties and therapeutic application of bromelain: a review.
Bronchitis, Chronic
[Crossed double-blind trial of potassium iodide and bromelain (Traumanase) in chronic bronchitis]
Carcinogenesis
Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer through Nrf2 and NF?B pathway.
Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway.
Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model.
Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin.
The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects.
Carcinoma
Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy.
Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition - A comparison with only bromelain.
Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21).
Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine.
Does Bromelain-Cisplatin Combination Afford In-Vitro Synergistic Anticancer Effects on Human Prostatic Carcinoma Cell Line, PC3?
Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients.
Hyaluronic acid grafted PLGA copolymer nanoparticles enhance the targeted delivery of Bromelain in Ehrlich's Ascites Carcinoma.
Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells.
Properties of gamma-glutamyl transpeptidase in squamous cell carcinoma.
Carcinoma, Ehrlich Tumor
Growth acceleration of Ehrlich ascites tumor cells treated by proteinase in vitro.
Carcinoma, Hepatocellular
Cytotoxic Effect of Bromelain on HepG2 Hepatocellular Carcinoma Cell Line.
gamma-Glutamyltransferase from human hepatoma tissue in comparison with normal liver enzyme.
Carcinoma, Squamous Cell
Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2) /M arrest to apoptosis.
Bromelain proteinase-f9 augments human lymphocyte-mediated growth-inhibition of various tumor-cells in-vitro.
Properties of gamma-glutamyl transpeptidase in squamous cell carcinoma.
Cardiovascular Diseases
A review of the use of bromelain in cardiovascular diseases.
Carpal Tunnel Syndrome
Electrophysiological and Clinical Improvement in Non-Invasive Treatment of Carpal Tunnel Syndrome.
Cheilitis
Bromelain: an unusual cause of allergic contact cheilitis.
Cholangiocarcinoma
Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines.
Cholera
Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro.
Colitis
Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.
Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.
Colitis, Ulcerative
Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.
Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.
Use of bromelain for mild ulcerative colitis.
Colonic Neoplasms
Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.
The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects.
Colorectal Neoplasms
Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis.
Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy.
The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects.
COVID-19
Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells.
Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein.
Bromelain: A Review on its Potential as a Therapy for the Management of Covid-19.
The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19.
Crohn Disease
Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.
Dental Caries
Bromelain vs Papain Gel for Caries Removal in Primary Teeth.
Diabetes Mellitus, Type 1
Prevention of murine EAE by oral hydrolytic enzyme treatment.
Diabetes Mellitus, Type 2
Identification and Comparison of Peptides from Chickpea Protein Hydrolysates Using Either Bromelain or Gastrointestinal Enzymes and Their Relationship with Markers of Type 2 Diabetes and Bitterness.
Drug Eruptions
Fixed drug eruption: A new side effect of bromelain.
Ecchymosis
Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature.
Perioperative Homeopathic Arnica and Bromelain: Current Results and Future Directions.
Encephalomyelitis
In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans.
Endometriosis
Alpha lipoic acid in obstetrics and gynecology.
Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study.
The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis.
Erythema
Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne. 1st communication: antiinflammatory, analgesic and other related properties.
Fatty Liver
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Food Hypersensitivity
Kiwi fruit allergy: a new birch pollen-associated food allergy.
Gastrointestinal Neoplasms
Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy.
Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells.
Glioma
Bromelain reversibly inhibits invasive properties of glioma cells.
Hepatitis A
Effect of Plant-Derived Proteases on Infectivity of Tulane Virus, Murine Norovirus, and Hepatitis A Virus.
Hyperalgesia
Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats.
Hyperlipidemias
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Hypersensitivity
Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure.
Asthma caused by bromelain: an occupational allergy.
Asthma caused by Ficus benjamina latex: evidence of cross-reactivity with fig fruit and papain.
Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.
Detection and inhibition of IgE antibodies reactive with cross-reactive carbohydrate determinants in an ELISA for allergen-specific IgE in horses.
Fruit-pollen-latex cross-reactivity: implication of profilin (Bet v 2).
Identification by immunoblot of venom glycoproteins displaying immunoglobulin E-binding N-glycans as cross-reactive allergens in honeybee and yellow jacket venom.
IgE-mediated allergy to bromelain.
In vitro hymenoptera venom allergy diagnosis: improved by screening for cross-reactive carbohydrate determinants and reciprocal inhibition.
Kiwi fruit allergy: a new birch pollen-associated food allergy.
Studies on the specificity of human IgE-antibodies to the plant proteases papain and bromelain.
Value of component based diagnostics in IgE-mediated hymenoptera sting reactions.
[Occupational allergies to bromelain]
Hypotension
Prolonged activated partial thromboplastin time and deficiency of high molecular weight kininogen in brown Norway rat mutant (Katholiek strain).
Ileus
Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase.
Infections
Applications of bromelain from pineapple waste towards acne.
Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli.
Bromelain: A Review on its Potential as a Therapy for the Management of Covid-19.
Proteolytic inhibition of Salmonella enterica serovar typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cells.
The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method.
Treatment of gastrointestinal infections.
Inflammatory Bowel Diseases
Anti-inflammatory properties of a proprietary bromelain extract (Bromeyal™) after in vitro simulated gastrointestinal digestion.
Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.
Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.
Proteinase activity and stability of natural bromelain preparations.
Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice.
Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.
Influenza, Human
An alternative method for preparation of pandemic influenza strain-specific antibody for vaccine potency determination.
Antigenic determinants of influenza virus haemagglutinin. X. A comparison of the physical and antigenic properties of monomeric and trimeric forms.
Attachment of influenza C virus to human erythrocytes.
Carbohydrates of influenza virus hemagglutinin: structures of the whole neutral sugar chains.
endo-beta-N-acetylglucosaminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both high-mannose and complex glycoproteins.
Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage.
Hybridoma antibodies produced against bromelain derived cores of influenza virus.
Influenza A virus M1 protein structure probed by in situ limited proteolysis with bromelain.
Influenza virus hemagglutinin spike neck architectures and interaction with model enzymes evaluated by MALDI-TOF mass spectrometry and bioinformatics tools.
Influenza virus pyrogenicity: central role of structural orientation of virion components and involvement of viral lipid and glycoproteins.
Isolation of the influenza C virus glycoprotein in a soluble form by bromelain digestion.
K2-tartarate gradient centrifugation in the isolation of purified influenza virus haemagglutinin after bromelain cleavage.
Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers.
Preparation-conditioned changes of the antigenicity of influenza virus neuraminidases.
Radioimmunoassay of influenza A virus haemagglutinin. I. Preparation and properties of radioactive 125I-labelled bromelain-released haemagglutinin.
Structure and composition of influenza virus. A small-angle neutron scattering study.
Structure of bromelain-released influenza virus haemagglutinin as revealed by electrophoresis, sedimentation and electron microscopy.
Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion.
The carbohydrate chains of influenza virus hemagglutinin.
The immunotargeting approach to adjuvant-independent immunization with influenza haemagglutinin.
The location of the bromelain cleavage site in a Hong Kong influenza virus Haemagglutinin.
[Changes in the antigenicity of influenza virus neuraminidases due to various methods of preparation]
[Influenza virus hemagglutinin: hydrodynamic properties and molecular weight]
[Internal epidemic influenza virus proteins: isolation and investigation]
[Successive isolation of hemagglutinin and neuraminidase from influenza virus A/Kransnodar/101/59 (H2N2) using bromelain]
[The structure of carbohydrate chains of hemagglutinin and neuraminidase of influenza virus B/Leningrad/179/86]
[The use of bromelain in obtaining the subviral particles of influenza A and B viruses]
Intestinal Fistula
Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli.
Joint Diseases
Benefits of a Food Supplement Containing Boswellia serrata and Bromelain for Improving the Quality of Life in Patients with Osteoarthritis: A Pilot Study.
Kidney Neoplasms
Arylamidase from human renal cancer tissue in comparison with normal kidney and placental enzymes.
Leukemia
Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14.
Bromelain proteinases modulate the cd44 expression on human molt-4/8 leukemia and sk-mel-28 melanoma-cells in-vitro.
Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition - A comparison with only bromelain.
Leukemia, Myeloid, Acute
Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition - A comparison with only bromelain.
Liver Diseases
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Liver Neoplasms
Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine - an in vitro study with pancreatic and hepatic cancer cells.
Liver Neoplasms, Experimental
Light form of Morris hepatoma gamma-glutamyltransferase.
Lung Neoplasms
Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer through Nrf2 and NF?B pathway.
[Preparation of McAb against lung cancer and its application in tumor radioimmunoimaging]
Lymphedema
Melilotus, Rutin and Bromelain in primary and secondary lymphedema.
Lymphoma
Bromelain plus peroxidase reduces non-Hodgkin lymphoma progression in invivo via up-regulation of antioxidant enzymes and modulating apoptotic protein expression.
Treatment of lymphomas via regulating the Signal transduction pathways by natural therapeutic approaches: A review.
Lymphoma, Non-Hodgkin
Bromelain plus peroxidase reduces non-Hodgkin lymphoma progression in invivo via up-regulation of antioxidant enzymes and modulating apoptotic protein expression.
Melanoma
Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa.
Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2) /M arrest to apoptosis.
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells.
Bromelain proteinase-f9 augments human lymphocyte-mediated growth-inhibition of various tumor-cells in-vitro.
In Vivo Antitumoral Activity of Stem Pineapple (Ananas comosus) Bromelain.
The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells.
Mesothelioma
Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells.
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma.
Metabolic Diseases
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Multiple Sclerosis
A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis.
Prevention of murine EAE by oral hydrolytic enzyme treatment.
Myalgia
Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.
The mechanistic effect of bromelain and papain on tenderization in jumbo squid (Dosidicus gigas) muscle.
Neoplasm Metastasis
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells.
In Vivo Antitumoral Activity of Stem Pineapple (Ananas comosus) Bromelain.
Modulation of pulmonary metastasis (Lewis lung carcinoma) by bromelain, an extract of the pineapple stem (Ananas comosus)
Neoplasms
A novel treatment of bromelain and acetylcysteine (BromAc) in patients with peritoneal mucinous tumours: A phase I first in man study.
Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.
Bromelain Enhances the Anti-tumor Effects of Cisplatin on 4T1 Breast Tumor Model In Vivo.
Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor.
Bromelain Inhibitory Effect on Colony Formation: An In vitro Study on Human AGS, PC3, and MCF7 Cancer Cells.
Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway.
Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14.
Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2) /M arrest to apoptosis.
Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy.
Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model.
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells.
Bromelain surface modification increases the diffusion of silica nanoparticles in the tumor extracellular matrix.
Bromelain treatment leads to maturation of monocyte-derived dendritic cells, but cannot replace PGE(2) in a cocktail of IL-1?, IL-6, TNF-? and PGE(2).
Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition - A comparison with only bromelain.
Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives.
Bromelain-decorated hybrid nanoparticles based on lactobionic acid-conjugated chitosan for in vitro anti-tumor study.
Bromelain-Induced Apoptosis in GI-101A Breast Cancer Cells.
Bromelain: biochemistry, pharmacology and medical use.
Characterization of variant gamma-glutamyl transpeptidase produced by pancreatocholangiocarcinoma cell lines in a protein-free, chemically defined medium.
Cisplatin bioconjugated enzymatic GNPs amplify the effect of cisplatin with acquiescence.
Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines.
Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21).
Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.
Differential release of membrane-bound alkaline phosphatase isoenzymes from tumor cells by bromelain.
Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients.
Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine - an in vitro study with pancreatic and hepatic cancer cells.
Evaluation of the Radiosensitizing Potency of Bromelain for Radiation Therapy of 4T1 Breast Cancer Cells.
Gene expression analysis in mcf-7 breast cancer cells treated with recombinant bromelain.
Growth acceleration of Ehrlich ascites tumor cells treated by proteinase in vitro.
Idarubicin-bromelain combination sensitizes cancer cells to conventional chemotherapy.
In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans.
In Vivo Antitumoral Activity of Stem Pineapple (Ananas comosus) Bromelain.
Induction of tumor necrosis factor in human peripheral-blood mononuclear cells by proteolytic enzymes.
Inhibition of tumour growth in vitro by bromelain, an extract of the pineapple plant (Ananas comosus).
Inhibition of Tumour Growth in vitro by Bromelain, an Extract of the Pineapple Plant (Ananas comosus).
Monoclonal antibodies block the bromelain-mediated release of human placental alkaline phosphatase from cultured cancer cells.
Nutritional and botanical modulation of the inflammatory cascade--eicosanoids, cyclooxygenases, and lipoxygenases--as an adjunct in cancer therapy.
On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects.
Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood.
pH-sensitive bromelain nanoparticles by ortho ester crosslinkage for enhanced doxorubicin penetration in solid tumor.
Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells.
Production of plant proteases in vivo and in vitro--a review.
Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin.
Selective modulation of cell adhesion molecules on lymphocytes by bromelain protease 5.
Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer.
Spontaneous healing and scar control following enzymatic debridement of deep second-degree burns.
Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation.
Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Study of the Radiosensitizing and Radioprotective Efficacy of Bromelain (a Pineapple Extract): In Vitro and In Vivo.
The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells.
The role of ferroptosis in digestive system cancer.
Utility of Bromelain and N-Acetylcysteine in Treatment of Peritoneal Dissemination of Gastrointestinal Mucin-Producing Malignancies.
Neuralgia
Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats.
Neurodegenerative Diseases
Modulation of Lipopolysaccharide Stimulated Nuclear Factor kappa B Mediated iNOS/NO Production by Bromelain in Rat Primary Microglial Cells.
Non-alcoholic Fatty Liver Disease
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Osteoarthritis
Anti-inflammatory properties of a proprietary bromelain extract (Bromeyal™) after in vitro simulated gastrointestinal digestion.
Benefits of a Food Supplement Containing Boswellia serrata and Bromelain for Improving the Quality of Life in Patients with Osteoarthritis: A Pilot Study.
Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies.
Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study.
Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis - A Randomised Clinical Trial.
Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study.
Osteoarthritis, Knee
Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study.
Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis.
Osteosarcoma
Cisplatin bioconjugated enzymatic GNPs amplify the effect of cisplatin with acquiescence.
Gold nanoconjugates reinforce the potency of conjugated cisplatin and doxorubicin.
Parkinsonian Disorders
Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism.
Peanut Hypersensitivity
Peanut allergy diagnosis in the context of grass pollen sensitization for 125 patients: roles of peanut and cross-reactive carbohydrate determinants specific IgE.
Pemphigoid, Bullous
The proteolytic effect of bromelain on bullous pemphigoid antigen-2.
Periodontitis
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Peripheral Nervous System Diseases
Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera(®)) for chemotherapy-induced peripheral neuropathy management, a prospective study.
Peritoneal Neoplasms
Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells.
Pityriasis Lichenoides
Role of bromelain in the treatment of patients with pityriasis lichenoides chronica.
Pleurisy
Assay methods for prekallikrein and kininogens and their applications.
Different modes of interaction of bradykinin with prostaglandins in pain and acute inflammation.
Effects of an orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisy.
Rat pleurisy induced by kaolin or croton oil: time course of fluid accumulation and white cell migration.
Prostatic Neoplasms
Biotechnological Potential of Araucaria angustifolia Pine Nuts Extract and the Cysteine Protease Inhibitor AaCI-2S.
Prostatitis
Serenoa repens associated with selenium and lycopene extract and bromelain and methylsulfonylmethane extract are able to improve the efficacy of levofloxacin in chronic bacterial prostatitis patients.
Pseudomyxoma Peritonei
Novel Use of Bromelain and Acetylcysteine (BromAc®) for Pleural Involvement in Pseudomyxoma Peritonei.
Pulmonary Edema
A study on the protective effect of bromelain, crude pineapple proteases, against adrenaline-induced pulmonary edema in rats.
Prevention of adrenaline-induced pulmonary edema by stem bromelain in rabbits and analysis of the hemodynamic changes.
PROTECTIVE EFFECT OF BROMELAIN AGAINST EPINEPHRINE PULMONARY EDEMA IN RATS.
Protective effect of stem bromelain against adrenaline pulmonary edema, and its dependence on the proteolytic activity.
[Disappearance of kiningen I by stem bromelain and the significance in prevention of pulmonary edema in rats]
Pyelonephritis
Bromelain: biochemistry, pharmacology and medical use.
Renal Insufficiency, Chronic
Modulation of serum levels of sRAGE by bromelain in patients with chronic kidney disease: a pilot study.
Reperfusion Injury
Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium.
Rheumatic Diseases
[Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti- inflammatory drugs versus an oral enzyme combination preparation]
Rhinitis, Allergic, Seasonal
Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy.
Sarcoma
The use of proteolysis with ficin, for immunostaining of paraffin sections. A study of lymphoid, mesenchymal, and epithelial determinants in human tissues.
Sepsis
Efficacy and safety of phlogenzym--a protease formulation, in sepsis in children.
Severe Acute Respiratory Syndrome
The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19.
Sinusitis
'Complementary ENT': a systematic review of commonly used supplements.
Bromelain: biochemistry, pharmacology and medical use.
Herbal medicines for the treatment of rhinosinusitis: a systematic review.
Properties and therapeutic application of bromelain: a review.
[Effect of bromelain in chronic sinusitis]
Skin Neoplasms
Bromelain as a skin cancer preventive in hairless mice.
Soft Tissue Injuries
A comparative study of the effects of bromelain and fresh pineapple juice on the early phase of healing in acute crush achilles tendon injury.
Attenuation of contraction-induced skeletal muscle injury by bromelain.
Thrombophilia
Bromelain has paradoxical effects on blood coagulability: a study using thromboelastography.
Thrombophlebitis
Bromelain: biochemistry, pharmacology and medical use.
Properties and therapeutic application of bromelain: a review.
Thrombosis
Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo.
Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients.
Tooth Mobility
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Triple Negative Breast Neoplasms
Bromelain Enhances the Anti-tumor Effects of Cisplatin on 4T1 Breast Tumor Model In Vivo.
Trismus
Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.
Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis.
Is bromelain effective in controlling the inflammatory parameters of pain, edema, and trismus after lower third molar surgery? A systematic review and meta-analysis.
Oral Bromelain for the Control of Facial Swelling, Trismus, and Pain After Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis.
Perioperative Bromelain Reduces Pain and Swelling and Improves Quality of Life Measures After Mandibular Third Molar Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Perioperative Homeopathic Arnica and Bromelain: Current Results and Future Directions.
Urinary Tract Infections
The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method.
Vesicular Stomatitis
Restitution of infectivity to spikeless vesicular stomatitis virus by solubilized viral components.