Disease on EC 3.4.22.32 - Stem bromelain
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Acquired Immunodeficiency Syndrome
The role of enzyme supplementation in digestive disorders.
Alveolar Bone Loss
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Alzheimer Disease
Bromelain degrades A?1-42 monomers and soluble aggregates: an in vitro study in cerebrospinal fluid of Alzheimer's disease patients.
Anaphylaxis
Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy.
Arthralgia
A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain.
Arthritis, Rheumatoid
Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults.
Arthritis, Rheumatoid
Exploration of bromelain laden nanostructured lipid carriers: An oral platform for bromelain delivery in rheumatoid arthritis management.
Asthma
Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure.
Asthma
Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.
Asthma
Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells.
Asthma
Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma.
Asthma
Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma.
Asthma
[Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]
Autoimmune Diseases
In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans.
Babesiosis
The effect of age on the infection and immunoresponsiveness of mice to Babesia microti.
Bacterial Infections
[Simultaneous therapy of inflammation and bacterial infection. Proteolytic activity of the saliva after administration of bromelain]
Breast Neoplasms
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma.
Breast Neoplasms
Bromelain Enhances the Anti-tumor Effects of Cisplatin on 4T1 Breast Tumor Model In Vivo.
Breast Neoplasms
Bromelain proteinase-f9 augments human lymphocyte-mediated growth-inhibition of various tumor-cells in-vitro.
Breast Neoplasms
Bromelain-Functionalized Multiple-Wall Lipid-Core Nanocapsules: Formulation, Chemical Structure and Antiproliferative Effect Against Human Breast Cancer Cells (MCF-7).
Breast Neoplasms
Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro.
Breast Neoplasms
Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients.
Breast Neoplasms
Evaluation of the Radiosensitizing Potency of Bromelain for Radiation Therapy of 4T1 Breast Cancer Cells.
Breast Neoplasms
Gene expression analysis in mcf-7 breast cancer cells treated with recombinant bromelain.
Breast Neoplasms
Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells.
Bronchitis
Polypeptides of the surface projections and the ribonucleoprotein of avian infectious bronchitis virus.
Bronchitis, Chronic
[Crossed double-blind trial of potassium iodide and bromelain (Traumanase) in chronic bronchitis]
Carcinogenesis
Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer through Nrf2 and NF?B pathway.
Carcinogenesis
Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway.
Carcinogenesis
Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model.
Carcinogenesis
Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin.
Carcinogenesis
The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects.
Carcinoma
Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy.
Carcinoma
Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition - A comparison with only bromelain.
Carcinoma
Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21).
Carcinoma
Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine.
Carcinoma
Does Bromelain-Cisplatin Combination Afford In-Vitro Synergistic Anticancer Effects on Human Prostatic Carcinoma Cell Line, PC3?
Carcinoma
Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients.
Carcinoma
Hyaluronic acid grafted PLGA copolymer nanoparticles enhance the targeted delivery of Bromelain in Ehrlich's Ascites Carcinoma.
Carcinoma
Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells.
Carcinoma, Ehrlich Tumor
Growth acceleration of Ehrlich ascites tumor cells treated by proteinase in vitro.
Carcinoma, Hepatocellular
Cytotoxic Effect of Bromelain on HepG2 Hepatocellular Carcinoma Cell Line.
Carcinoma, Hepatocellular
gamma-Glutamyltransferase from human hepatoma tissue in comparison with normal liver enzyme.
Carcinoma, Squamous Cell
Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2) /M arrest to apoptosis.
Carcinoma, Squamous Cell
Bromelain proteinase-f9 augments human lymphocyte-mediated growth-inhibition of various tumor-cells in-vitro.
Carcinoma, Squamous Cell
Properties of gamma-glutamyl transpeptidase in squamous cell carcinoma.
Carpal Tunnel Syndrome
Electrophysiological and Clinical Improvement in Non-Invasive Treatment of Carpal Tunnel Syndrome.
Cholangiocarcinoma
Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines.
Cholera
Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro.
Colitis
Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.
Colitis
Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.
Colitis, Ulcerative
Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.
Colitis, Ulcerative
Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.
Colonic Neoplasms
Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.
Colonic Neoplasms
The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects.
Colorectal Neoplasms
Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis.
Colorectal Neoplasms
Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy.
Colorectal Neoplasms
The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects.
COVID-19
Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein.
COVID-19
The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19.
Crohn Disease
Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.
Diabetes Mellitus, Type 2
Identification and Comparison of Peptides from Chickpea Protein Hydrolysates Using Either Bromelain or Gastrointestinal Enzymes and Their Relationship with Markers of Type 2 Diabetes and Bitterness.
Ecchymosis
Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature.
Ecchymosis
Perioperative Homeopathic Arnica and Bromelain: Current Results and Future Directions.
Encephalomyelitis
In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans.
Endometriosis
Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study.
Endometriosis
The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis.
Erythema
Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne. 1st communication: antiinflammatory, analgesic and other related properties.
Fatty Liver
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Fatty Liver
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Gastrointestinal Neoplasms
Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy.
Gastrointestinal Neoplasms
Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells.
Hepatitis A
Effect of Plant-Derived Proteases on Infectivity of Tulane Virus, Murine Norovirus, and Hepatitis A Virus.
Hyperalgesia
Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats.
Hyperlipidemias
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Hypersensitivity
Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure.
Hypersensitivity
Asthma caused by Ficus benjamina latex: evidence of cross-reactivity with fig fruit and papain.
Hypersensitivity
Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.
Hypersensitivity
Detection and inhibition of IgE antibodies reactive with cross-reactive carbohydrate determinants in an ELISA for allergen-specific IgE in horses.
Hypersensitivity
Identification by immunoblot of venom glycoproteins displaying immunoglobulin E-binding N-glycans as cross-reactive allergens in honeybee and yellow jacket venom.
Hypersensitivity
In vitro hymenoptera venom allergy diagnosis: improved by screening for cross-reactive carbohydrate determinants and reciprocal inhibition.
Hypersensitivity
Studies on the specificity of human IgE-antibodies to the plant proteases papain and bromelain.
Hypersensitivity
Value of component based diagnostics in IgE-mediated hymenoptera sting reactions.
Hypotension
Prolonged activated partial thromboplastin time and deficiency of high molecular weight kininogen in brown Norway rat mutant (Katholiek strain).
Ileus
Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase.
Infections
Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli.
Infections
Bromelain: A Review on its Potential as a Therapy for the Management of Covid-19.
Infections
Proteolytic inhibition of Salmonella enterica serovar typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cells.
Infections
The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method.
Inflammatory Bowel Diseases
Anti-inflammatory properties of a proprietary bromelain extract (Bromeyal) after in vitro simulated gastrointestinal digestion.
Inflammatory Bowel Diseases
Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.
Inflammatory Bowel Diseases
Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.
Inflammatory Bowel Diseases
Proteinase activity and stability of natural bromelain preparations.
Inflammatory Bowel Diseases
Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice.
Inflammatory Bowel Diseases
Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.
Influenza, Human
An alternative method for preparation of pandemic influenza strain-specific antibody for vaccine potency determination.
Influenza, Human
Antigenic determinants of influenza virus haemagglutinin. X. A comparison of the physical and antigenic properties of monomeric and trimeric forms.
Influenza, Human
Carbohydrates of influenza virus hemagglutinin: structures of the whole neutral sugar chains.
Influenza, Human
endo-beta-N-acetylglucosaminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both high-mannose and complex glycoproteins.
Influenza, Human
Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage.
Influenza, Human
Hybridoma antibodies produced against bromelain derived cores of influenza virus.
Influenza, Human
Influenza A virus M1 protein structure probed by in situ limited proteolysis with bromelain.
Influenza, Human
Influenza virus hemagglutinin spike neck architectures and interaction with model enzymes evaluated by MALDI-TOF mass spectrometry and bioinformatics tools.
Influenza, Human
Influenza virus pyrogenicity: central role of structural orientation of virion components and involvement of viral lipid and glycoproteins.
Influenza, Human
Isolation of the influenza C virus glycoprotein in a soluble form by bromelain digestion.
Influenza, Human
K2-tartarate gradient centrifugation in the isolation of purified influenza virus haemagglutinin after bromelain cleavage.
Influenza, Human
Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers.
Influenza, Human
Preparation-conditioned changes of the antigenicity of influenza virus neuraminidases.
Influenza, Human
Radioimmunoassay of influenza A virus haemagglutinin. I. Preparation and properties of radioactive 125I-labelled bromelain-released haemagglutinin.
Influenza, Human
Structure and composition of influenza virus. A small-angle neutron scattering study.
Influenza, Human
Structure of bromelain-released influenza virus haemagglutinin as revealed by electrophoresis, sedimentation and electron microscopy.
Influenza, Human
Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion.
Influenza, Human
The immunotargeting approach to adjuvant-independent immunization with influenza haemagglutinin.
Influenza, Human
The location of the bromelain cleavage site in a Hong Kong influenza virus Haemagglutinin.
Influenza, Human
[Changes in the antigenicity of influenza virus neuraminidases due to various methods of preparation]
Influenza, Human
[Influenza virus hemagglutinin: hydrodynamic properties and molecular weight]
Influenza, Human
[Successive isolation of hemagglutinin and neuraminidase from influenza virus A/Kransnodar/101/59 (H2N2) using bromelain]
Influenza, Human
[The structure of carbohydrate chains of hemagglutinin and neuraminidase of influenza virus B/Leningrad/179/86]
Influenza, Human
[The use of bromelain in obtaining the subviral particles of influenza A and B viruses]
Intestinal Fistula
Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli.
Joint Diseases
Benefits of a Food Supplement Containing Boswellia serrata and Bromelain for Improving the Quality of Life in Patients with Osteoarthritis: A Pilot Study.
Kidney Neoplasms
Arylamidase from human renal cancer tissue in comparison with normal kidney and placental enzymes.
Leukemia
Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14.
Leukemia
Bromelain proteinases modulate the cd44 expression on human molt-4/8 leukemia and sk-mel-28 melanoma-cells in-vitro.
Leukemia
Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition - A comparison with only bromelain.
Leukemia, Myeloid, Acute
Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition - A comparison with only bromelain.
Liver Diseases
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Liver Diseases
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Liver Neoplasms
Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine - an in vitro study with pancreatic and hepatic cancer cells.
Lung Neoplasms
Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer through Nrf2 and NF?B pathway.
Lung Neoplasms
[Preparation of McAb against lung cancer and its application in tumor radioimmunoimaging]
Lymphoma
Bromelain plus peroxidase reduces non-Hodgkin lymphoma progression in invivo via up-regulation of antioxidant enzymes and modulating apoptotic protein expression.
Lymphoma
Treatment of lymphomas via regulating the Signal transduction pathways by natural therapeutic approaches: A review.
Lymphoma, Non-Hodgkin
Bromelain plus peroxidase reduces non-Hodgkin lymphoma progression in invivo via up-regulation of antioxidant enzymes and modulating apoptotic protein expression.
Melanoma
Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa.
Melanoma
Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2) /M arrest to apoptosis.
Melanoma
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells.
Melanoma
Bromelain proteinase-f9 augments human lymphocyte-mediated growth-inhibition of various tumor-cells in-vitro.
Melanoma
The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells.
Mesothelioma
Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells.
Mesothelioma
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma.
Metabolic Diseases
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Multiple Sclerosis
A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis.
Myalgia
Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.
Myalgia
The mechanistic effect of bromelain and papain on tenderization in jumbo squid (Dosidicus gigas) muscle.
Neoplasm Metastasis
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells.
Neoplasm Metastasis
In Vivo Antitumoral Activity of Stem Pineapple (Ananas comosus) Bromelain.
Neoplasm Metastasis
Modulation of pulmonary metastasis (Lewis lung carcinoma) by bromelain, an extract of the pineapple stem (Ananas comosus)
Neoplasms
A novel treatment of bromelain and acetylcysteine (BromAc) in patients with peritoneal mucinous tumours: A phase I first in man study.
Neoplasms
Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.
Neoplasms
Bromelain Enhances the Anti-tumor Effects of Cisplatin on 4T1 Breast Tumor Model In Vivo.
Neoplasms
Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor.
Neoplasms
Bromelain Inhibitory Effect on Colony Formation: An In vitro Study on Human AGS, PC3, and MCF7 Cancer Cells.
Neoplasms
Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway.
Neoplasms
Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14.
Neoplasms
Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2) /M arrest to apoptosis.
Neoplasms
Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy.
Neoplasms
Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model.
Neoplasms
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells.
Neoplasms
Bromelain surface modification increases the diffusion of silica nanoparticles in the tumor extracellular matrix.
Neoplasms
Bromelain treatment leads to maturation of monocyte-derived dendritic cells, but cannot replace PGE(2) in a cocktail of IL-1?, IL-6, TNF-? and PGE(2).
Neoplasms
Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition - A comparison with only bromelain.
Neoplasms
Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives.
Neoplasms
Bromelain-decorated hybrid nanoparticles based on lactobionic acid-conjugated chitosan for in vitro anti-tumor study.
Neoplasms
Characterization of variant gamma-glutamyl transpeptidase produced by pancreatocholangiocarcinoma cell lines in a protein-free, chemically defined medium.
Neoplasms
Cisplatin bioconjugated enzymatic GNPs amplify the effect of cisplatin with acquiescence.
Neoplasms
Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines.
Neoplasms
Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21).
Neoplasms
Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.
Neoplasms
Differential release of membrane-bound alkaline phosphatase isoenzymes from tumor cells by bromelain.
Neoplasms
Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients.
Neoplasms
Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine - an in vitro study with pancreatic and hepatic cancer cells.
Neoplasms
Evaluation of the Radiosensitizing Potency of Bromelain for Radiation Therapy of 4T1 Breast Cancer Cells.
Neoplasms
Gene expression analysis in mcf-7 breast cancer cells treated with recombinant bromelain.
Neoplasms
Growth acceleration of Ehrlich ascites tumor cells treated by proteinase in vitro.
Neoplasms
Idarubicin-bromelain combination sensitizes cancer cells to conventional chemotherapy.
Neoplasms
In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans.
Neoplasms
Induction of tumor necrosis factor in human peripheral-blood mononuclear cells by proteolytic enzymes.
Neoplasms
Inhibition of tumour growth in vitro by bromelain, an extract of the pineapple plant (Ananas comosus).
Neoplasms
Inhibition of Tumour Growth in vitro by Bromelain, an Extract of the Pineapple Plant (Ananas comosus).
Neoplasms
Monoclonal antibodies block the bromelain-mediated release of human placental alkaline phosphatase from cultured cancer cells.
Neoplasms
Nutritional and botanical modulation of the inflammatory cascade--eicosanoids, cyclooxygenases, and lipoxygenases--as an adjunct in cancer therapy.
Neoplasms
On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects.
Neoplasms
Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood.
Neoplasms
pH-sensitive bromelain nanoparticles by ortho ester crosslinkage for enhanced doxorubicin penetration in solid tumor.
Neoplasms
Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells.
Neoplasms
Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin.
Neoplasms
Selective modulation of cell adhesion molecules on lymphocytes by bromelain protease 5.
Neoplasms
Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer.
Neoplasms
Spontaneous healing and scar control following enzymatic debridement of deep second-degree burns.
Neoplasms
Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation.
Neoplasms
Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Neoplasms
Study of the Radiosensitizing and Radioprotective Efficacy of Bromelain (a Pineapple Extract): In Vitro and In Vivo.
Neoplasms
The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells.
Neoplasms
Utility of Bromelain and N-Acetylcysteine in Treatment of Peritoneal Dissemination of Gastrointestinal Mucin-Producing Malignancies.
Neuralgia
Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats.
Neurodegenerative Diseases
Modulation of Lipopolysaccharide Stimulated Nuclear Factor kappa B Mediated iNOS/NO Production by Bromelain in Rat Primary Microglial Cells.
Non-alcoholic Fatty Liver Disease
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Non-alcoholic Fatty Liver Disease
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Osteoarthritis
Anti-inflammatory properties of a proprietary bromelain extract (Bromeyal) after in vitro simulated gastrointestinal digestion.
Osteoarthritis
Benefits of a Food Supplement Containing Boswellia serrata and Bromelain for Improving the Quality of Life in Patients with Osteoarthritis: A Pilot Study.
Osteoarthritis
Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study.
Osteoarthritis
Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis - A Randomised Clinical Trial.
Osteoarthritis
Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study.
Osteoarthritis, Knee
Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study.
Osteoarthritis, Knee
Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis.
Osteosarcoma
Cisplatin bioconjugated enzymatic GNPs amplify the effect of cisplatin with acquiescence.
Osteosarcoma
Gold nanoconjugates reinforce the potency of conjugated cisplatin and doxorubicin.
Parkinsonian Disorders
Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism.
Peanut Hypersensitivity
Peanut allergy diagnosis in the context of grass pollen sensitization for 125 patients: roles of peanut and cross-reactive carbohydrate determinants specific IgE.
Periodontitis
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Peripheral Nervous System Diseases
Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera(®)) for chemotherapy-induced peripheral neuropathy management, a prospective study.
Peritoneal Neoplasms
Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells.
Pityriasis Lichenoides
Role of bromelain in the treatment of patients with pityriasis lichenoides chronica.
Pleurisy
Different modes of interaction of bradykinin with prostaglandins in pain and acute inflammation.
Pleurisy
Effects of an orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisy.
Pleurisy
Rat pleurisy induced by kaolin or croton oil: time course of fluid accumulation and white cell migration.
Prostatic Neoplasms
Biotechnological Potential of Araucaria angustifolia Pine Nuts Extract and the Cysteine Protease Inhibitor AaCI-2S.
Prostatitis
Serenoa repens associated with selenium and lycopene extract and bromelain and methylsulfonylmethane extract are able to improve the efficacy of levofloxacin in chronic bacterial prostatitis patients.
Pseudomyxoma Peritonei
Novel Use of Bromelain and Acetylcysteine (BromAc®) for Pleural Involvement in Pseudomyxoma Peritonei.
Pulmonary Edema
A study on the protective effect of bromelain, crude pineapple proteases, against adrenaline-induced pulmonary edema in rats.
Pulmonary Edema
Prevention of adrenaline-induced pulmonary edema by stem bromelain in rabbits and analysis of the hemodynamic changes.
Pulmonary Edema
PROTECTIVE EFFECT OF BROMELAIN AGAINST EPINEPHRINE PULMONARY EDEMA IN RATS.
Pulmonary Edema
Protective effect of stem bromelain against adrenaline pulmonary edema, and its dependence on the proteolytic activity.
Pulmonary Edema
[Disappearance of kiningen I by stem bromelain and the significance in prevention of pulmonary edema in rats]
Renal Insufficiency, Chronic
Modulation of serum levels of sRAGE by bromelain in patients with chronic kidney disease: a pilot study.
Reperfusion Injury
Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium.
Rheumatic Diseases
[Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti- inflammatory drugs versus an oral enzyme combination preparation]
Rhinitis, Allergic, Seasonal
Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy.
Sarcoma
The use of proteolysis with ficin, for immunostaining of paraffin sections. A study of lymphoid, mesenchymal, and epithelial determinants in human tissues.
Severe Acute Respiratory Syndrome
The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19.
Soft Tissue Injuries
A comparative study of the effects of bromelain and fresh pineapple juice on the early phase of healing in acute crush achilles tendon injury.
Soft Tissue Injuries
Attenuation of contraction-induced skeletal muscle injury by bromelain.
Thrombophilia
Bromelain has paradoxical effects on blood coagulability: a study using thromboelastography.
Thrombosis
Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo.
Thrombosis
Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients.
Tooth Mobility
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Triple Negative Breast Neoplasms
Bromelain Enhances the Anti-tumor Effects of Cisplatin on 4T1 Breast Tumor Model In Vivo.
Trismus
Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.
Trismus
Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis.
Trismus
Is bromelain effective in controlling the inflammatory parameters of pain, edema, and trismus after lower third molar surgery? A systematic review and meta-analysis.
Trismus
Oral Bromelain for the Control of Facial Swelling, Trismus, and Pain After Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis.
Trismus
Perioperative Bromelain Reduces Pain and Swelling and Improves Quality of Life Measures After Mandibular Third Molar Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Trismus
Perioperative Homeopathic Arnica and Bromelain: Current Results and Future Directions.
Urinary Tract Infections
The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method.
Vesicular Stomatitis
Restitution of infectivity to spikeless vesicular stomatitis virus by solubilized viral components.
html completed