Disease on EC 3.4.22.2 - papain
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Acne Vulgaris
Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres.
Alopecia
[Pharmacological action of 101-B hair regeneration extract on skin and hair in experimental animals]
Alzheimer Disease
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Anaphylaxis
Anaphylaxis induced by a drug containing lysozyme and papain: influence of papain on the IgE response.
Anaphylaxis
Local ocular anaphylaxis to papain enzyme contained in a contact lens cleansing solution.
Anaphylaxis
Studies on the immunologic mechanism of anaphylaxis. II. Sensitizing and combining capacity in vivo of fractions separated from papain digests of antihapten antibody.
Anemia
[Action of papain associated with iron and ascorbic acid in the treatment of anemias caused by phenylhydrazine.]
Anemia
[Contribution to the study of the physiological synthesis of hemoglobin. IV. The role of papain in the treatment of simple anemias.]
Anemia, Hemolytic
[The papain crust test in the serological diagnosis of fetal erythroblastosis and auto-immune hemolytic anemia.]
Anemia, Hemolytic, Autoimmune
Effects of papain on the agglutination of canine red cells with serum autoantibodies.
Anemia, Hemolytic, Autoimmune
Use of papain for the detection of incomplete erythrocyte autoantibodies in autoimmune haemolytic anaemia of the dog and cat.
Anemia, Hypochromic
[Effect of papain on regeneration of hemoglobin in simple and hypochromic anemia.]
Aneurysm
Development of a new experimental model of saccular aneurysm by intra-arterial incubation of papain in rabbits.
Angioedema
Local ocular anaphylaxis to papain enzyme contained in a contact lens cleansing solution.
Aortic Aneurysm, Abdominal
A novel in vivo rabbit model of abdominal aortic aneurysm induced by periarterial incubation of papain.
Arteriosclerosis
Fish protein hydrolysates affect cholesterol metabolism in rats fed non-cholesterol and high-cholesterol diets.
Arthritis
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Arthritis
Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B.
Arthritis
Fresh immature articular cartilage allografts. A study on the integration of chondral and osteochondral grafts both in normal and in papain-treated knee joints of rabbits.
Arthritis
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.
Arthritis
The early evaluation of induced osteoarthritis in rats with 99Tcm-pertechnetate scans.
Arthritis
[The effects of low-dose Co-60 irradiation on the course of aseptic arthritis in a rabbit knee joint]
Arthritis, Rheumatoid
Acid glycosaminoglycans in plasma. II. Findings in rheumatoid arthritis.
Arthritis, Rheumatoid
Early detection of rheumatoid arthritis in rats and humans with 99mTc-3PRGD2 scintigraphy: imaging synovial neoangiogenesis.
Arthritis, Rheumatoid
The binding constants of IgM rheumatoid factors and their univalent fragments for native and aggregated human IgG;.
Arthritis, Rheumatoid
[The synovial membrane in rheumatoid arthritis: change in the glycosaminoglycan pattern]
Asthma
Asthma caused by Ficus benjamina latex: evidence of cross-reactivity with fig fruit and papain.
Asthma
Interleukin-28B dampens protease-induced lung inflammation via IL-25 and TSLP inhibition in epithelial cells.
Asthma
Papain Degrades Tight Junction Proteins of Human Keratinocytes In-Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of Its Enzymatic Activity or TLR4 Activation.
Asthma
[Contact urticaria, rhinoconjunctivitis and bronchial asthma from occupational use of papain.]
Asthma
[Immunotherapy effect of ploypeptide vaccine of allergen group 1 from Dermatophagoides farinae on asthma mice].
Asthma, Occupational
Occupational asthma after inhalation of dust of the proteolytic enzyme, papain.
Asthma, Occupational
Papain-induced occupational rhinoconjunctivitis and asthma - A case report.
Atherosclerosis
[Role of glycosaminoglycans in the pathogenesis of vertebral osteochondrosis (clinico-experimental study)]
Bacterial Infections
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Blister
Localization and role of calcium in the erythrocyte coat: effects of enzymes and storage.
Bone Resorption
Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption.
Bone Resorption
Potent and selective ketoamide-based inhibitors of cysteine protease, cathepsin K.
Bone Resorption
Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.
Brain Ischemia
Autonomic Cardiac Regulation in Experimental Comorbidity of Chronic Obstructive Pulmonary Disease and Acute Cerebral Ischemia.
Breast Neoplasms
Biochemical and immunochemical analysis of a breast carcinoma associated antigen defined by the monoclonal antibody NCRC-11.
Breast Neoplasms
Formulation and evaluation of hyaluronic acid-based mucoadhesive self nanoemulsifying drug delivery system (SNEDDS) of tamoxifen for targeting breast cancer.
Bronchial Spasm
[Proteolytic lung emphysema and obstructive airway disease (author's transl)]
Carcinogenesis
Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe.
Carcinoma
Electrophoretic analysis of the "cross-class" interaction between novel inhibitory serpin, squamous cell carcinoma antigen-1 and cysteine proteinases.
Carcinoma
Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases.
Carcinoma
Tumor-associated and embryonic antigens in soluble fractions of a chemically-induced rat colon carcinoma.
Carcinoma, Hepatocellular
Comparative structural and lectin-binding studies on gamma-glutamyltransferase from human adult liver, fetal liver and primary hepatoma.
Carcinoma, Hepatocellular
Comparison of electrophoretic and immunological properties of gamma-glutamyl transpeptidase from human adult liver, fetal liver and primary hepatoma.
Carcinoma, Hepatocellular
Concanavalin A and wheat germ agglutinin receptors in the ascitic fluid of rat hepatomas.
Carcinoma, Hepatocellular
Induction of gamma-glutamyl transpeptidase by hexachlorocyclohexane.
Carcinoma, Hepatocellular
Purification of detergent-solubilized form and membrane-binding domain of rat gamma-glutamyltransferase by immuno-affinity and hydrophobic chromatography.
Carcinoma, Lewis Lung
Inhibition of tumor growth, invasion and metastasis in papain-immunized mice.
Carcinoma, Squamous Cell
Electrophoretic analysis of the "cross-class" interaction between novel inhibitory serpin, squamous cell carcinoma antigen-1 and cysteine proteinases.
Carcinoma, Squamous Cell
Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases.
Cholangiocarcinoma
Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines.
Cholera
Adherent surface mucus gel restricts diffusion of macromolecules in rat duodenum in vivo.
Cholera
Correlation between macrophages and their membrane fraction. Cytocidal activities on neoplastic cells.
Cholera
Resistance of purified cholera toxin to enzymatic treatment with pancreatic elastase and papain.
Chondrosarcoma
Structural studies on sulfated glycopeptides from the carbohydrate-protein linkage region of chondroitin 4-sulfate proteoglycans of swarm rat chondrosarcoma. Demonstration of the structure Gal(4-O-sulfate)beta 1-3Gal beta 1-4XYL beta 1-O-Ser.
Colorectal Neoplasms
Significance of tumour mass on T-lymphocyte levels in patients with gastrointestinal cancer.
Confusion
Comparative study of osteoarthritis (OA) induced by monoiodoacetate (MIA) and papain in rabbit temporomandibular joints: macroscopic and microscopic analysis.
Conjunctivitis
Local ocular anaphylaxis to papain enzyme contained in a contact lens cleansing solution.
Conjunctivitis
Topical ocular treatment with monoclonal antibody Fab fragments targeting Japanese cedar pollen Cry j 1 inhibits Japanese cedar pollen-induced allergic conjunctivitis in mice.
Conjunctivitis
Treatment of contact lenses with papain. Increase in wearing time in keratoconic patients with papillary conjunctivitis.
Corneal Opacity
[Phonophoresis of papain and lekozim in the treatment of leukoma and opacity of the cornea]
Coronavirus Infections
Whole Genome Analysis and Targeted Drug Discovery Using Computational Methods and High Throughput Screening Tools for Emerged Novel Coronavirus (2019-nCoV).
Cough
Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies.
Cystic Fibrosis
Isolation and characterization of the plasma membranes of cultured lymphoblasts from patients with cystic fibrosis and normal individuals.
Cysts
A serine proteinase in the penetration glands of the hexacanths of Hymenolepis diminuta (Cestoda, Cyclophyllidea).
Dermatitis
Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.
Dermatitis, Contact
Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres.
Diphtheria
DIPHTHERIA ANTITOXIN: ANTIGEN-COMBINING AND TOXIN-NEUTRALIZING PROPERTIES OF PAPAIN FRAGMENTS.
Diphtheria
[Antagonistic effect of salmine, papain and thymus histone on the inflammatory action of diphtheria toxin on guinea pig skin.]
Diphtheria
[IMMUNOCHEMICAL ANALYSIS OF PRODUCTS OF PAPAIN PROTEOLYSIS OF DIPHTHERIA HORSE ANTITOXIC GAMMA GLOBULIN.]
Discitis
[Analysis of the results of surgery and nucleolysis using papain in 1085 cases of lumbar disk hernias]
Dwarfism
[OSTEO-CARTILAGINOUS DYSTROPHY AND NANISM EXPERIMENTALLY INDUCED IN THE MONKEY AND RABBIT BY PAPAIN ADMINISTRATION.]
Dyspnea
Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: evidence for strong immunogenic potency and clinically relevant 'proteolytic effects of airborne papain'.
Dyspnea
[Pharmacological studies on shengenaqi oral liquid on animal model for TCM dyspnea of deficiency]
Echinococcosis
[Cure of five hydatid cysts of the lungs by bronchial aspiration; contribution of the adjuvant methods: varidase, trypsin, papain, ultra-sound.]
Elephantiasis, Filarial
[Evaluation of the indirect immunofluorescence test for the diagnosis of bancroftian filariasis using microfilariae W. bancrofti as the antigen, in Recife-PE, Brazil]
Elephantiasis, Filarial
[Use of microfilaria treated with papain in the serodiagnosis of lymphatic filariasis caused by Wuchereria bancrofti (Var. pacifica)]
Encephalitis, Tick-Borne
[FAB immunoglobulin fragments. I. The comparative characteristics of the serological and virus-neutralizing properties of a gamma globulin against tick-borne encephalitis and of the FAB fragments isolated from it]
Enterobiasis
[Present state of the oral therapy of enterobiasis; application of papain and combined papain-piperazine therapy with special regard to child communities.]
Eosinophilia
Characterization of a novel, papain-inducible murine model of eosinophilic rhinosinusitis.
Eosinophilia
Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants.
Eosinophilia
Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.
Eosinophilia
Epicutaneous vaccination with protease inhibitor-treated papain prevents papain-induced Th2-mediated airway inflammation without inducing Th17 in mice.
Eosinophilia
IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation.
Eosinophilia
IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.
Eosinophilia
Innate IL-17A enhances IL-33-independent skin eosinophilia and IgE response on subcutaneous papain sensitization.
Eosinophilia
Interplay Between the IL-33/ST2 Axis and Bone Marrow ILC2s in Protease Allergen-Induced IL-5-Dependent Eosinophilia.
Eosinophilia
Platelets constitutively express IL-33 protein and modulate eosinophilic airway inflammation.
Eosinophilia
Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes.
Erythema
Efficacy of Topical Treatments for Chrysaora chinensis Species: A Human Model in Comparison with an In Vitro Model.
Erythroblastosis, Fetal
[The papain crust test in the serological diagnosis of fetal erythroblastosis and auto-immune hemolytic anemia.]
Escherichia coli Infections
Effect of papain on experimental E. coli infection: a preliminary report.
Foot-and-Mouth Disease
A structural model of picornavirus leader proteinases based on papain and bleomycin hydrolase.
Gastrointestinal Diseases
Region-specific effects of the cysteine protease papain on gastric motility.
Gastrointestinal Diseases
Significance of tumour mass on T-lymphocyte levels in patients with gastrointestinal cancer.
Gingivitis
Anti-plaque and anti-gingivitis effect of Papain, Bromelain, Miswak and Neem containing dentifrice: A randomized controlled trial.
Glaucoma, Open-Angle
Peptides of the variable IgG domain as potential biomarker candidates in primary open-angle glaucoma (POAG).
Glomerulonephritis
Restoration of antigenicity of tissue antigens, cell-bound immunoglobulins and immune deposits in paraffin-embedded tissue. The influence of fixation and proteolytic enzymatic digestion.
Glomerulonephritis
[Incidence of the occurrence of erythrocyte agglutinating antibodies coated with incomplete IgG or the products of their pepsin and papain digestion in chronic glomerulonephritis and dialysis patients]
Helminthiasis
[A new therapy of intestinal helminthiasis by nematodes: in vitro experience with the proteolytic ferment papain.]
Hematologic Diseases
[Studies on immunity tests with Rh-sensitized and papain and trypsin treated erythrocytes in blood diseases.]
Hemorrhagic Septicemia
Possibilities of preparation of an oil adjuvant vaccine against haemorrhagic septicaemia of cattle using a medium containing papain digest of beef.
Hepatic Insufficiency
[Value of papain in treatment of hyperproteinemia, of acute and chronic shock and of the manifestations of hepatic insufficiency in general.]
Hepatitis
Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus.
Hepatitis A
Effect of Plant-Derived Proteases on Infectivity of Tulane Virus, Murine Norovirus, and Hepatitis A Virus.
Hepatitis E
Hepatitis E Virus Cysteine Protease Has Papain Like Properties Validated by in silico Modeling and Cell-Free Inhibition Assays.
Herpes Zoster
Evaluation of human sperm-zona pellucida tight binding by presence of monoclonal antibodies to sperm antigens.
HIV Infections
Enzymatic cleavage of a CD4 immunoadhesin generates crystallizable, biologically active Fd-like fragments.
Hyperalgesia
Photobiomodulation therapy in the modulation of inflammatory mediators and bradykinin receptors in an experimental model of acute osteoarthritis.
Hyperalgesia
The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin.
Hyperlipidemias
Induction of hyperlipemia by carbohydrate-rich fractions isolated from crude papain.
Hyperlipidemias
[Hyperlipemia induced in rabbits by intravenous injection of human serum orosomucoid (alpha 1 acid glycoprotein) in comparison with that induced by injection of crude papain]
Hypersensitivity
Anaphylaxis induced by a drug containing lysozyme and papain: influence of papain on the IgE response.
Hypersensitivity
Asthma caused by Ficus benjamina latex: evidence of cross-reactivity with fig fruit and papain.
Hypersensitivity
Comparative modelling of major house dust mite allergen Der p I: structure validation using an extended environmental amino acid propensity table.
Hypersensitivity
Enzymatically active papain preferentially induces an allergic response in mice.
Hypersensitivity
Incidence and risk factors for latent sensitization to chymopapain: predictive skin-prick tests in 700 candidates for chemonucleolysis.
Hypersensitivity
Listeria infection inhibits IgE production in regional lymph nodes by suppressing chemotaxis of basophils to lymph nodes.
Hypersensitivity
Papain-induced asthma: diagnosis by skin test, RAST and bronchial provocation test.
Hypersensitivity
Pharmacokinetic and Pharmacological Aspects of a Papain-Based Enzyme Solution for Rescuing Clogged Enteral Feeding Tubes.
Hypersensitivity
Phosphorylation and Enzymatic Hydrolysis with Alcalase and Papain Effectively Reduce Allergic Reactions to Gliadins in Normal Mice.
Hypersensitivity
Sensitization to Ficus benjamina: relationship to natural rubber latex allergy and identification of foods implicated in the Ficus-fruit syndrome.
Hypersensitivity
Studies on the specificity of human IgE-antibodies to the plant proteases papain and bromelain.
Hypersensitivity
The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge.
Hypersensitivity
Total dose defines the incidence of percutaneous IgE/IgG1 mediated immediate-type hypersensitivity caused by papain.
Hypersensitivity
[Contact urticaria, rhinoconjunctivitis and bronchial asthma from occupational use of papain.]
Hypersensitivity, Immediate
Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: evidence for strong immunogenic potency and clinically relevant 'proteolytic effects of airborne papain'.
Infections
A Phytophthora palmivora Extracellular Cystatin-Like Protease Inhibitor Targets Papain to Contribute to Virulence on Papaya.
Infections
Discovery of small molecule PLpro inhibitor against COVID-19 using structure-based virtual screening, molecular dynamics simulation, and molecular mechanics/Generalized Born surface area (MM/GBSA) calculation.
Infections
In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA Dependent RNA polymerase (RdRp) and Essential Proteases.
Infections
Induction of Protective Immune Responses Against Schistosomiasis haematobium in Hamsters and Mice Using Cysteine Peptidase-Based Vaccine.
Infections
Inhibition of the in vitro outgrowth of Epstein-Barr virus-transformed lymphocytes by thymus-dependent lymphocytes from infectious mononucleosis patients.
Infections
Mycotoxins from Fusarium proliferatum: new inhibitors of papain-like cysteine proteases.
Infections
Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH2 immunity.
Infections
Papain-Based Vaccination Modulates Schistosoma mansoni Infection-Induced Cytokine Signals.
Infections
Porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein (NSP)1 transcriptionally inhibits CCN1 and CCN2 expression by blocking ERK-AP-1 axis in pig macrophages in vitro.
Infections
TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers.
Infections
[Chemotherapeutic effectiveness of antibiotics in combination with papain in experimental septicemia]
Infectious Mononucleosis
[Technical simplification of the papain test according to Wöllner for the serodiagnosis of infectious mononucleosis using preserved sheep erythrocytes]
Influenza, Human
The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.
Influenza, Human
[Inhibitory activity of blood group antigens M and N in inhibition of virus hemagglutination reactions of influenza viruses]
Intervertebral Disc Displacement
[Analysis of the results of surgery and nucleolysis using papain in 1085 cases of lumbar disk hernias]
Intervertebral Disc Displacement
[Long-term 10-year outcome after chemonucleolysis for lumbar disc herniation]
Joint Diseases
Degenerative joint disease of the canine hip: experimental production by multiple papain and prednisone injections.
Joint Diseases
Effect of selected antirheumatic drugs on the metabolism of cartilage and synovial tissue in experimental arthropathy.
Leukemia
Bromelain proteinases modulate the cd44 expression on human molt-4/8 leukemia and sk-mel-28 melanoma-cells in-vitro.
Leukemia
Human B-lymphocyte antigens expressed by lymphocytic and myelocytic leukemia cells. II. Detection by human anti-B-cell alloantisera.
Leukemia
Purification of murine thymus leukemia antigen (TL). A quantitative assessment of limited proteolysis.
Leukemia
Some biochemical properties of thymus leukemia antigens solubilized from cell membranes by papain digestion.
Leukemia L1210
[Quantitative evaluation of the surface membrane receptors of leukemic cells to blood serum transcobalamin-II]
Lung Diseases
Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies.
Lung Diseases, Interstitial
Early primary immune response against erythrocytes: a case report.
Lung Diseases, Obstructive
A mouse model of asthma-chronic obstructive pulmonary disease overlap induced by intratracheal papain.
Lung Injury
Aerosol deposition and dispersion characterize lung injury in a canine model of emphysema.
Lung Injury
Aerosol probes of emphysema progression in dogs treated with all trans retinoic acid--an exploratory study.
Lung Injury
Assessment of papain-induced lung injury in isolated lungs by measurements of aerosol deposition and mixing.
Lung Injury
[The effect of pentoxifylline on the degree of lung parenchyma injury after papain]
Lymphoma
Immunohistochemical analysis of non-Hodgkin's lymphomas with the monoclonal antibody to follicular center lymphocytes reactive in paraffin sections.
Malaria
Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5.
Malaria
Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum.
Marek Disease
In vitro cytotoxicity against Marek's disease lymphoblastoid cell lines after enzymatic removal of Marek's disease tumor-associated surface antigen.
Mastitis
[Use of papain and ultrasound in the combined treatment of gangrenous lactation mastitis]
Melanoma
AU cell-surface antigen of human malignant melanoma: solubilization and partial characterization.
Melanoma
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells.
Melanoma
Mixture of trypsin, chymotrypsin and papain reduces formation of metastases and extends survival time of C57Bl6 mice with syngeneic melanoma B16.
Melanoma
Polyenzyme preparation Wobe-Mugos inhibits growth of solid tumors and development of experimental metastases in mice.
Melanoma
Surface antigenic characteristics of human melanoma cells defined by xenoantiserum raised against papain-solubilized melanoma-associated antigens.
Melanoma, Experimental
Inhibition of tumor growth, invasion and metastasis in papain-immunized mice.
Melanoma, Experimental
Mixture of trypsin, chymotrypsin and papain reduces formation of metastases and extends survival time of C57Bl6 mice with syngeneic melanoma B16.
Melanoma, Experimental
Purification and characterization of a low molecular mass cysteine proteinase inhibitor from human amniotic fluid.
Mesothelioma
Electrophoresis of tissue glycosaminoglycans as an aid in the diagnosis of mesotheliomas.
Mesothelioma
Secondary and tertiary structures of hyaluronan in aqueous solution, investigated by rotary shadowing-electron microscopy and computer simulation. Hyaluronan is a very efficient network-forming polymer.
Musculoskeletal Diseases
The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.
Myalgia
The mechanistic effect of bromelain and papain on tenderization in jumbo squid (Dosidicus gigas) muscle.
Myasthenia Gravis
Treatment of passively transferred experimental autoimmune myasthenia gravis using papain.
Myoma
Non-phosphorylative transglucosylation and other biochemical indices in serum and uterine myoma in women.
Neoplasm Metastasis
Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats.
Neoplasm Metastasis
Inhibition of tumor growth, invasion and metastasis in papain-immunized mice.
Neoplasm Metastasis
Mixture of trypsin, chymotrypsin and papain reduces formation of metastases and extends survival time of C57Bl6 mice with syngeneic melanoma B16.
Neoplasms
A common tumour-specific antigen: III. Preparation of small fragments incorporating the cell-sensitizing determinant.
Neoplasms
Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B.
Neoplasms
Biological and biochemical properties of soluble tumor-specific transplantation antigen of a simian virus 40-induced neoplasm.
Neoplasms
Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines.
Neoplasms
Cysteine proteinase inhibitor in cultured human medullary thyroid carcinoma cells.
Neoplasms
Detergent extraction and characterization of tumor hemolytic factor from plasma membranes of oncogene transformed fibroblasts.
Neoplasms
Effect of Low Level Laser Therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation.
Neoplasms
Effect of neuraminidase and papain treatment on lectin-induced agglutination of Novikoff tumor cells and assay of lectin receptor activity of the glycopeptides released from the cell surface by papain.
Neoplasms
Electrophoresis of tissue glycosaminoglycans as an aid in the diagnosis of mesotheliomas.
Neoplasms
Enzymatic removal of H-2 alloantigens from the surface of P815-(X2) mouse tumor cells.
Neoplasms
Fab(nimotuzumab)-HYNIC-99mTc: Antibody fragmentation for molecular imaging agents.
Neoplasms
Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats.
Neoplasms
Identification and preclinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model.
Neoplasms
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.
Neoplasms
Induction of tumor necrosis factor in human peripheral-blood mononuclear cells by proteolytic enzymes.
Neoplasms
Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer.
Neoplasms
Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma.
Neoplasms
Isolation and characterization of anti-proliferative peptides from Chinese three-striped box turtle (Cuora trifasciata).
Neoplasms
Mixture of trypsin, chymotrypsin and papain reduces formation of metastases and extends survival time of C57Bl6 mice with syngeneic melanoma B16.
Neoplasms
Modulation of the immune response to transplantation antigens. IV. Enhanced growth of tumour allografts in mice immunised with papain-solubilised transplantation antigen.
Neoplasms
Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure.
Neoplasms
Non-phosphorylative transglucosylation and other biochemical indices in serum and uterine myoma in women.
Neoplasms
Optimized flow cytometric analysis of central nervous system tissue reveals novel functional relationships among cells expressing CD133, CD15, and CD24.
Neoplasms
Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood.
Neoplasms
Papain grafted into the silica coated iron-based magnetic nanoparticles 'IONPs@SiO2-PPN' as a new delivery vehicle to the HeLa cells.
Neoplasms
Proteomic identification of an MHC-binding peptidome from pancreas and breast cancer cell lines.
Neoplasms
Purification and comparison of several catalytic parameters of the gamma-glutamyltranspeptidase of rat mammary adenocarcinoma (13762) and of normal rat mammary gland.
Neoplasms
Purification of murine thymus leukemia antigen (TL). A quantitative assessment of limited proteolysis.
Neoplasms
Quantitative in vivo studies of soluble simian virus 40 tumor-specific transplantation antigens of the mouse.
Neoplasms
Significance of tumour mass on T-lymphocyte levels in patients with gastrointestinal cancer.
Neoplasms
Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation.
Neoplasms
Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Neoplasms
The isolation and characterization of tumor-specific antigens of rodent and human tumors.
Neoplasms
The use of papain and of mediators of the nervous activity: histamine and acetylcholine, for differentiating glycoproteins in blood of patients with cancer.
Neoplasms
Tumor cell-platelet aggregation: induced by cathepsin B-like proteinase and inhibited by prostacyclin.
Neoplasms
Tumor-associated and embryonic antigens in soluble fractions of a chemically-induced rat colon carcinoma.
Neoplasms
Usefulness of cytofluorometric DNA ploidy analysis in distinguishing benign cartilaginous tumors from chondrosarcomas.
Neuroblastoma
Evidence that neutral sphingomyelinase of cultured murine neuroblastoma cells is oriented externally on the plasma membrane.
Neuroblastoma
Human gammadelta T lymphocytes exert natural and IL-2-induced cytotoxicity to neuroblastoma cells.
Osteoarthritis
Activity of anti-inflammatory drugs on an experimental model of osteoarthritis.
Osteoarthritis
Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice.
Osteoarthritis
Comparative study of osteoarthritis (OA) induced by monoiodoacetate (MIA) and papain in rabbit temporomandibular joints: macroscopic and microscopic analysis.
Osteoarthritis
Comparison of the chondroprotective effect of a novel hydrogel compound and traditional hyaluronate on rat cartilage in a papain-induced osteoarthritis model.
Osteoarthritis
Early detection of rheumatoid arthritis in rats and humans with 99mTc-3PRGD2 scintigraphy: imaging synovial neoangiogenesis.
Osteoarthritis
Effects of a hyaluronic acid and low molecular weight heparin injection on osteoarthritis in rabbits.
Osteoarthritis
Effects of knee injection on skeletal muscle metabolism and contractile force in rats.
Osteoarthritis
Effects of Uygur sand therapy on the mechanical properties of femurs in osteoarthritic rabbits.
Osteoarthritis
Evaluation of anti-osteoarthritic activity of Vigna mungo in papain induced osteoarthritis model.
Osteoarthritis
Inflammatory cytokines via up-regulation of aquaporins deteriorated the pathogenesis of early osteoarthritis.
Osteoarthritis
Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression.
Osteoarthritis
Intra-articular injection of collagenase induces experimental osteoarthritis in mature rabbits.
Osteoarthritis
Isolated and combined effects of photobiomodulation therapy, topical nonsteroidal anti-inflammatory drugs, and physical activity in the treatment of osteoarthritis induced by papain.
Osteoarthritis
No beneficial effects of joint distraction on early microscopical changes in osteoarthrotic knees. A study in rabbits.
Osteoarthritis
Photobiomodulation therapy in the modulation of inflammatory mediators and bradykinin receptors in an experimental model of acute osteoarthritis.
Osteoarthritis
The early evaluation of induced osteoarthritis in rats with 99Tcm-pertechnetate scans.
Osteoarthritis
The role of mucopolysaccharide induction in treatment of experimental osteoarthritis in rats by ultrasound.
Osteoarthritis
Triamcinolone acetonide activates an anti-inflammatory and folate receptor-positive macrophage that prevents osteophytosis in vivo.
Osteoarthritis
[A study on papain-induced osteoarthritis in rabbit temporomandibular joint]
Osteoarthritis
[Comparative study on effects of sodium hyaluronate and prednisolone injections on experimental temporomandibular joint osteoarthritis of rabbits]
Osteoarthritis
[Effect of SL-1010 (sodium hyaluronate with high molecular weight) on experimental osteoarthritis induced by intra-articularly applied papain in rabbits]
Osteoarthritis
[Effects of SL-1010 (sodium hyaluronate with high molecular weight) on experimental osteoarthritis induced by intra-articularly applied papain in guinea pigs]
Osteoarthritis
[Quantification of papain-induced rat osteoarthritis in relation to time with the Mankin score.]
Osteoarthritis, Knee
Evaluation of pharmacokinetics and pharmaco-dynamics of sinomenine-hyaluronic acid conjugate after intra-articular administration for osteoarthritis treatment.
Osteoarthritis, Knee
Gas chromatography-time of flight/mass spectrometry-based metabonomics of changes in the urinary metabolic profile in osteoarthritic rats.
Osteoarthritis, Knee
[Comparison study on knee osteoarthritis in rabbits induced by different concentrations of papain].
Osteochondrosis
[Biochemical mechanisms of the action of papain on the connective tissue of the intervertebral disks in osteochondrosis]
Osteochondrosis
[Clinico-electromyographic parallels in the evaluation of the results of treating lumbar osteochondrosis by the papain nucleolysis technic]
Osteochondrosis
[Effectiveness of treatment of lumbar osteochondrosis with intradiscal infusion of papain]
Osteochondrosis
[Role of glycosaminoglycans in the pathogenesis of vertebral osteochondrosis (clinico-experimental study)]
Osteochondrosis
[Treatment of the neurological syndromes of lumbar osteochondrosis by the intradisk administration of papain]
Osteochondrosis
[Use of Soviet papain enzyme in the disk-puncture treatment of lumbar osteochondrosis]
Osteochondrosis
[Use of the proteolytic enzyme papain in the treatment of cervical osteochondrosis]
Osteophyte
Development and pharmacological characterization of a rat model of osteoarthritis pain.
Osteophyte
Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis.
Osteophyte
The reaction of cartilage and osteophyte formation after the intraarticular injection of papain.
Osteoporosis
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Osteoporosis
An orally active cathepsin K inhibitor, furan-2-carboxylic acid, 1-{1-[4-fluoro-2-(2-oxo-pyrrolidin-1-yl)-phenyl]-3-oxo-piperidin-4-ylcarbamoyl}-cyclohexyl)-amide (OST-4077), inhibits osteoclast activity in vitro and bone loss in ovariectomized rats.
Pancreatic Neoplasms
Enhanced tumor localization of radiolabeled Fab fragments of monoclonal antibody A7 in nude mice bearing human pancreatic carcinoma xenografts.
Parasitic Diseases
In vitro efficacy of latex and purified papain from Carica papaya against Strongyloides venezuelensis eggs and larvae.
Parasitic Diseases
Vinyl sulfones as antiparasitic agents and a structural basis for drug design.
Periarthritis
[Treatment of humero-scapular periarthritis and epicondylitis of the shoulder with proteolytic enzyme, papain]
Periodontal Pocket
Antimicrobial photodynamic chemotherapy mediated by PapaMBlue on chronic periodontal disease: Study protocol for a randomized, blind, controlled trial.
Periodontal Pocket
Inhibitory effect of serum globulins on the adhesion of Prevotella nigrescens to hydroxyapatite.
Pneumonia
Aspiration pneumonitis following papain enzyme treatment for oesophageal meat impaction.
Pneumonia
BLT1 signaling in epithelial cells mediates allergic sensitization via promotion of IL-33 production.
Pneumonia
Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation.
Pneumonia
IL-17-producing ST2+ group 2 innate lymphoid cells play a pathogenic role in lung inflammation.
Pneumonia
The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice.
Pneumonia
Thymic Stromal Lymphopoietin Enhances Th2/Th22 and Reduces IL-17A in Protease-Allergen-Induced Airways Inflammation.
Poliomyelitis
[Localization of the specific neutralizing activity in poliomyelitis antibodies treated with papain, pepsin and reducing agents]
Pressure Ulcer
Genotoxic and Cytotoxic Safety Evaluation of Papain (Carica papaya L.) Using In Vitro Assays.
Prostatic Neoplasms
Biotechnological Potential of Araucaria angustifolia Pine Nuts Extract and the Cysteine Protease Inhibitor AaCI-2S.
Prostatic Neoplasms
Papain mediated synthesized gold nanoparticles encore the potency of bioconjugated Flutamide.
Pruritus
Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents.
Pruritus
[Pharmacological action of 101-B hair regeneration extract on skin and hair in experimental animals]
Psoriasis
Biochemical properties of thiol proteinase inhibitor purified from psoriatic scales.
Pulmonary Disease, Chronic Obstructive
Aspiration pneumonitis following papain enzyme treatment for oesophageal meat impaction.
Pulmonary Disease, Chronic Obstructive
Behavioral and Cognitive Reactions of Rats with Experimental Chronic Obstructive Lung Diseases of Different Degree.
Pulmonary Disease, Chronic Obstructive
Lung hyaluronan levels are decreased in alpha-1 antiprotease deficiency COPD.
Pulmonary Disease, Chronic Obstructive
Overexpression of the hyperplasia suppressor gene inactivates airway fibroblasts obtained from a rat model of chronic obstructive pulmonary disease by inhibiting the Wnt signaling pathway.
Pulmonary Disease, Chronic Obstructive
[Proteolytic lung emphysema and obstructive airway disease (author's transl)]
Pulmonary Edema
Hemorrhagic pulmonary edema associated with meat tenderizer treatment for esophageal meat impaction.
Pulmonary Emphysema
A new, simple stapling technique for pulmonary emphysema: its effects and safety for improving respiratory function.
Pulmonary Emphysema
Experimental study of pulmonary emphysema in rats exposed to coal dust and papain: effects on the infrastructure and the cell dynamics.
Pulmonary Emphysema
Expiratory flow limitation and the response to breathing a helium-oxygen gas mixture in a canine model of pulmonary emphysema.
Pulmonary Emphysema
Morphogenesis of rat experimental pulmonary emphysema induced by intratracheally administered papain: changes in elastic fibres.
Pulmonary Emphysema
Oxidative and proteolysis-related parameters of skeletal muscle from hamsters with experimental pulmonary emphysema: a comparison between papain and elastase induction.
Pulmonary Emphysema
Pulmonary vascular structural and functional changes in papain-induced emphysema in dogs.
Pulmonary Emphysema
[Bronchospirometric results after single lung homotransplantation in dogs with experimentally induced pulmonary emphysema (author's transl)]
Pulmonary Emphysema
[Changes of lung function in experimentally induced emphysema before and after unilateral homotransplantation of the canine lung]
Pulmonary Emphysema
[Effects of bone marrow mesenchymal stem cells transplantation on the apoptosis of alveolar wall cells in papain and Co60-induced pulmonary emphysema rats].
Pulmonary Emphysema
[Free alveolar cells in experimental pulmonary emphysema. I. Statistical analysis of cellular composition and lung morphometry]
Pulmonary Emphysema
[Studies on the effect of molecular damage to elastin and collagen on the development of experimental pulmonary emphysema induced by papain]
Purpura, Thrombocytopenic, Idiopathic
Use of enzyme treatment to enhance reactivity of HLA and platelet-specific antibodies in solid-phase RBC adherence assays.
Renal Insufficiency, Chronic
Ultrasensitive sensor for detection of early stage chronic kidney disease in human.
Respiratory Distress Syndrome
Ultrastructural analysis of pulmonary capillaries in the course of experimental lung emphysema.
Rhinitis
[Contact urticaria, rhinoconjunctivitis and bronchial asthma from occupational use of papain.]
Rickets
Localization of sudanophil material at the sites of calcification in dentine, and the compact bone and epiphyseal cartilage plate of tibia in the rat given beryllium carbonate.
Sarcoma
Biological and biochemical properties of soluble tumor-specific transplantation antigen of a simian virus 40-induced neoplasm.
Sarcoma
Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma.
Sarcoma, Avian
A lymphoma protein with an in vitro site of tyrosine phosphorylation homologous to that in pp60src.
Scabies
Contribution of cutinase serine 42 side chain to the stabilization of the oxyanion transition state.
Schistosomiasis
Role of T lymphocytes and papain enzymatic activity in the protection induced by the cysteine protease against Schistosoma mansoni in mice.
Schistosomiasis mansoni
VACCINE-INDUCED PROTECTION AGAINST MURINE SCHISTOSOMIASIS MANSONI WITH LARVAL EXCRETORY-SECRETORY ANTIGENS AND PAPAIN OR TYPE-2 CYTOKINES.
Sepsis
[Chemotherapeutic effectiveness of antibiotics in combination with papain in experimental septicemia]
Serum Sickness
Restoration of antigenicity of tissue antigens, cell-bound immunoglobulins and immune deposits in paraffin-embedded tissue. The influence of fixation and proteolytic enzymatic digestion.
Shock, Septic
Identification of functional antigenic segments of toxic shock syndrome toxin 1 by differential immunoreactivity and by differential mitogenic responses of human peripheral blood mononuclear cells, using active toxin fragments.
Skin Ulcer
[Pharmacological action of 101-B hair regeneration extract on skin and hair in experimental animals]
Smear Layer
A scanning electron microscope study on the effect of an experimental irrigation solution on smear layer removal.
Smear Layer
Deproteinization of caries-affected dentin with chemo-mechanical caries removal agents and its effect on dentin bonding with self-etch adhesives.
Spinal Osteochondrosis
[Roentgenometric follow-up after the papain therapy of spinal osteochondrosis patients]
Spinal Osteochondrosis
[Treatment of spinal osteochondrosis by the subcutaneous administration of papain (lekozym) in combination with galvanization]
Stomach Neoplasms
The mucolytic action of papain for cell concentration in the diagnosis of gastric cancer.
Strongyloidiasis
In vitro efficacy of latex and purified papain from Carica papaya against Strongyloides venezuelensis eggs and larvae.
Synovitis
Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis.
Synovitis
[Study of therapeutic effect and mechanism of Sihuang powder treating acute synovitis in experimental rabbit induced by papain injection]
Tetanus
A candidate carrier protein for beta-human chorionic gonadotropin: 54,000-molecular-weight fragment of tetanus toxin.
Tetanus
Enzymatic fragmentation of tetanus toxin. Identification and characterization of an atoxic, immunogenic fragment.
Tetanus
Light chain of tetanus toxin intracellularly inhibits acetylcholine release at neuro-neuronal synapses, and its internalization is mediated by heavy chain.
Tetanus
Structure of tetanus toxin. I. Breakdown of the toxin molecule and discrimination between polypeptide fragments.
Tetanus
Structure of tetanus toxin: the arrangement of papain digestion products within the heavy chain-light chain framework of extracellular toxin.
Tetanus
The use of antibody Fab fragments specifically directed to two different complementary parts of the tetanus toxin molecule for studying the mode of action of the toxin.
Thrombocytopenia
Thrombocytopenia after second exposure to abciximab is caused by antibodies that recognize abciximab-coated platelets.
Thymoma
Characterization of the neutral aminopeptidase activity associated to the mouse thymocyte-activating molecule.
Thyroid Neoplasms
Abnormal accumulation of proteoglycan in human thyroid adenocarcinoma tissue.
Transfusion Reaction
A prospective study of the incidence of red cell allo-immunisation following transfusion.
Typhoid Fever
Clearance of Salmonella typhimurium in mice and immunology to mouse typhoid: a comparison of the activities of hyperimmune rabbit gamma-globulin and Porter's fragment I obtained by papain hydrolysis.
Urticaria
[Contact urticaria, rhinoconjunctivitis and bronchial asthma from occupational use of papain.]
Uterine Cervical Neoplasms
Purification and identification of novel cytotoxic oligopeptides from soft coral Sarcophyton glaucum.
Varicose Ulcer
Effectiveness of papain gel in venous ulcer treatment: randomized clinical trial.
Varicose Ulcer
Fibrin gel versus papain gel in the healing of chronic venous ulcers: A double-blind randomized controlled trial.
Vascular Diseases
Hypertensive pulmonary vascular disease associated with papain emphysema in rats.
Virus Diseases
Early interactions of human herpesvirus 6 with lymphoid cells: role of membrane protein components and glycosaminoglycans in virus binding.
Virus Diseases
In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA Dependent RNA polymerase (RdRp) and Essential Proteases.
Virus Diseases
The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.
Whooping Cough
Separation and characterization of two distinct hemagglutinins contained in purified leukocytosis-promoting factor from Bordetella pertussis.
Whooping Cough
[Fluorescent FAB-fragments of antibodies. Comparative assessment and utilization in immunofluorescent analysis]
html completed