Information on EC 3.4.21.B45 - kallikrein 14

Substrates: -
Products: -

HASR-4-nitroanilide + H2O

HASR + 4-nitroaniline

Substrates: -
Products: -

HAVR-4-nitroanilide + H2O

HAVR + 4-nitroaniline

Substrates: -
Products: -

HLNR-4-nitroanilide + H2O

HLNR + 4-nitroaniline

Substrates: -
Products: -

HLSR-4-nitroanilide + H2O

HLSR + 4-nitroaniline

Substrates: -
Products: -

HLVR-4-nitroanilide + H2O

HLVR + 4-nitroaniline

Substrates: -
Products: -

human proteinase-activated receptor 2 zymogen + H2O

mature human proteinase-activated receptor 2 + ?

Substrates: unmasking the PAR2 receptor-activating sequence from a peptide precursor
Products: -

HVNR-4-nitroanilide + H2O

HVNR + 4-nitroaniline

Substrates: -
Products: -

HVSR-4-nitroanilide + H2O

HVSR + 4-nitroaniline

Substrates: -
Products: -

HVVR-4-nitroanilide + H2O

HVVR + 4-nitroaniline

Substrates: -
Products: -

L-Gln-Gly-Asp-Lys-Ile-Ile-Asp + H2O

L-Gln-Gly-Asp-Lys + Ile-Ile-Asp

Substrates: 41% cleavage after 1 h incubation
Products: -

L-Glu-Thr-Arg-Ile-Ile-Lys + H2O

L-Glu-Thr-Arg + Ile-Ile-Lys

Substrates: 55% cleavage after 1 h incubation
Products: -

L-Ile-Gln-Ser-Arg-Ile-Val-Gly + H2O

L-Ile-Gln-Ser-Arg + Ile-Val-Gly

Substrates: 97% cleavage after 1 h incubation
Products: -

L-Ile-Leu-Ser-Arg-Ile-Val-Gly + H2O

L-Ile-Leu-Ser-Arg + Ile-Val-Gly

Substrates: 87% cleavage after 1 h incubation
Products: -

L-Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O

L-Pro-Phe-Arg + 7-amino-4-methylcoumarin

Substrates: -
Products: -

L-Pro-Phe-Arg-p-nitroanilide + H2O

L-Pro-Phe-Arg + p-nitroaniline

Substrates: -
Products: -

L-Ser-Ser-Ser-Arg-Ile-Ile-Asn + H2O

L-Ser-Ser-Ser-Arg + Ile-Ile-Asn

Substrates: 57% cleavage after 1 h incubation
Products: -

Laminin + H2O

Substrates: -
Products: -

laminin alpha-1 precursor + H2O

Substrates: residues 1988-1991
Products: -

laminin alpha-5 + H2O

Substrates: -
Products: -

MANR-4-nitroanilide + H2O

MANR + 4-nitroaniline

Substrates: -
Products: -

MASR-4-nitroanilide + H2O

MASR + 4-nitroaniline

Substrates: -
Products: -

matrillin-4 precursor + H2O

Substrates: residues 178-182
Products: -

MAVR-4-nitroanilide + H2O

MAVR + 4-nitroaniline

Substrates: -
Products: -

methoxy-succinyl-Arg-Pro-Tyr-p-nitroanilide + H2O

methoxy-succinyl-Arg-Pro-Tyr + p-nitroaniline

678525

Substrates: very low activity
Products: -

MLNR-4-nitroanilide + H2O

MLNR + 4-nitroaniline

Substrates: -
Products: -

MLSR-4-nitroanilide + H2O

MLSR + 4-nitroaniline

Substrates: -
Products: -

MLVR-4-nitroanilide + H2O

MLVR + 4-nitroaniline

Substrates: -
Products: -

MVNR-4-nitroanilide + H2O

MVNR + 4-nitroaniline

Substrates: -
Products: -

MVSR-4-nitroanilide + H2O

MVSR + 4-nitroaniline

Substrates: -
Products: -

MVVR-4-nitroanilide + H2O

MVVR + 4-nitroaniline

Substrates: -
Products: -

NATLDPRSFLLRNPNDKYE + H2O

NATLDPR + SFLLRNPNDKYE

Substrates: the tethered ligand is SFLLRN
Products: -

polypeptide + H2O

peptides

Substrates: -
Products: -

pro-hepatocyte growth factor + H2O

Substrates: the enzyme converts pro-hepatocyte growth factor to the two-chain heterodimer required for Met activation, while higher concentrations degrade the hepatocyte growth factor alpha-chain. When pro-hepatocyte growth factor is in vast excess it is activated by KLK14, and as the substrate concentration increases above a threshold level (protease:substrate ratio above 1:200), hepatocyte growth factor is inactivated
Products: -

pro-KLK11 + H2O

KLK11 + ?

Substrates: -
Products: -

pro-KLK3 + H2O

KLK3 + ?

Substrates: KLK3 is activated by cleavage after arginine at position 7
Products: -

proMMP14 + H2O

MMP14 + prodomain

Substrates: -
Products: -

proMMP15 + H2O

MMP15 + prodomain

Substrates: -
Products: -

proMMP16 + H2O

MMP16 + prodomain

Substrates: -
Products: -

proMMP17 + H2O

MMP17 + prodomain

Substrates: -
Products: -

proprotein convertase subtilisin/kexin type 5 precursor + H2O

Substrates: residues 371-375
Products: -

proteinase-activated receptor 2 zymogen + H2O

mature proteinase-activated receptor 2 + ?

Substrates: -
Products: -

QAR-7-amido-4-methylcoumarin + H2O

Substrates: -
Products: -

rat proteinase-activated receptor 2 zymogen + H2O

mature rat proteinase-activated receptor 2 + ?

Substrates: unmasking the PAR2 receptor-activating sequence from a peptide precursor
Products: -

semenogelin I + H2O

Substrates: -
Products: -

semenogelin II + H2O

Substrates: -
Products: -

serin protease inhibitor Kazal-type 5 precursor + H2O

Substrates: residues 1034-1037
Products: -

tosyl-Gly-L-Pro-L-Arg-4-nitroanilide + H2O

tosyl-Gly-L-Pro-L-Arg + 4-nitroaniline

Substrates: -
Products: -

vascular endothelial growth factor receptor 3 precursor + H2O

Substrates: residues 1126-1130
Products: -

VGSLR-4-nitroanilide + H2O

VGSLR + 4-nitroaniline

Substrates: -
Products: -

villin-like protein + H2O

Substrates: residues 61-65
Products: -

Vitronectin + H2O

Substrates: -
Products: -

WANR-4-nitroanilide + H2O

WANR + 4-nitroaniline

Substrates: -
Products: -

WASR-4-nitroanilide + H2O

WASR + 4-nitroaniline

Substrates: -
Products: -

WAVR-4-nitroanilide + H2O

WAVR + 4-nitroaniline

Substrates: -
Products: -

WLNR-4-nitroanilide + H2O

WLNR + 4-nitroaniline

Substrates: -
Products: -

WLSR-4-nitroanilide + H2O

WLSR + 4-nitroaniline

Substrates: -
Products: -

WLVR-4-nitroanilide + H2O

WLVR + 4-nitroaniline

Substrates: -
Products: -

WVNR-4-nitroanilide + H2O

WVNR + 4-nitroaniline

Substrates: -
Products: -

WVSR-4-nitroanilide + H2O

WVSR + 4-nitroaniline

Substrates: -
Products: -

WVVR-4-nitroanilide + H2O

WVVR + 4-nitroaniline

Substrates: -
Products: -

YAAR-4-nitroanilide + H2O

YAAR + 4-nitroaniline

Substrates: -
Products: -

YANR-4-nitroanilide + H2O

YANR + 4-nitroaniline

Substrates: -
Products: -

YASR-4-nitroanilide + H2O

YASR + 4-nitroaniline

Substrates: -
Products: -

YAVR-4-nitroanilide + H2O

YAVR + 4-nitroaniline

Substrates: -
Products: -

YLNR-4-nitroanilide + H2O

YLNR + 4-nitroaniline

Substrates: -
Products: -

YLSR-4-nitroanilide + H2O

YLSR + 4-nitroaniline

Substrates: -
Products: -

YLVR-4-nitroanilide + H2O

YLVR + 4-nitroaniline

Substrates: -
Products: -

YVNR-4-nitroanilide + H2O

YVNR + 4-nitroaniline

Substrates: -
Products: -

YVSR-4-nitroanilide + H2O

YVSR + 4-nitroaniline

Substrates: -
Products: -

YVVR-4-nitroanilide + H2O

YVVR + 4-nitroaniline

Substrates: -
Products: -

additional information

10 entries

additional information

Substrates: does not cleave L-Glu-Ser-Ser-Lys-Val-Leu-Asn, L-Ser-Cys-Ser-Gln-Ile-Ile-Asn, L-Glu-Gln-Asn-Lys-Leu-Val-His, L-Gln-Glu-Asp-Lys-Val-Leu-Gly, L-Asp-Thr-Arg-Ala-Ile-Gly, L-Asn-Asp-Thr-Arg-Leu-Asp-Pro, L-Asp-Glu-Asn-Lys-Ile-Ile-Gly, and L-Asp-Gly-Asp-Lys-Leu-Leu-Glu
Products: -

additional information

additional information

Substrates: crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
Products: -

additional information

Substrates: crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
Products: -

additional information

Substrates: the enzyme activates the proteinase-activated receptor 2 recombinnatly expressed in rat and in human cells
Products: -

additional information

Substrates: the enzyme activates the proteinase-activated receptor 2 recombinnatly expressed in rat and in human cells
Products: -

additional information

Substrates: KLK14 can cleave synthetic peptides representing the cleavage-activation sequences of human proteinase-activated receptors PARs 1, 2 and 4 to unmask a receptor-activating sequence. Substrate specificity, overview. Analysis of processing of synthetic human and rat proteinase-activated receptor 2, PAR2, derived sequences, representing the cleavage activation domain of PAR2, by kallikrein 8 versus kallikrein 14. KLKs 8 and 14 can both cleave the synthetic PAR2 tethered ligand-containing synthetic peptides to unmask a potential receptor-activating sequence, but each KLK exhibits distinct signalling properties via PARs 1 and 2
Products: -

additional information

additional information

Substrates: determination of substrate and cleavage site specificities of the enzyme using peptide fused to 4-nitroanilide as substrates, molecular modeling of preferred KLK14 substrates. The enzyme KLK14 displays a preference for Tyr and Trp at the P4 site
Products: -

additional information

Substrates: membrane-type MMPs are targeted by KLK14 for activation. proMMP14-17 are effectively processed by KLK14
Products: -

show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

airway trypsin-like protease precursor + H2O

Substrates: residues 6-10
Products: -

collagen alpha1 (XII and XIX) chain precursor + H2O

Substrates: residues 1838-1841
Products: -

collagen alpha3 (IV) chain precursor + H2O

Substrates: residues 832-835
Products: -

Collagen IV + H2O

Substrates: -
Products: -

endothelin-2 precursor + H2O

Substrates: residues 145-149
Products: -

laminin alpha-1 precursor + H2O

Substrates: residues 1988-1991
Products: -

laminin alpha-5 + H2O

Substrates: -
Products: -

matrillin-4 precursor + H2O

Substrates: residues 178-182
Products: -

polypeptide + H2O

peptides

Substrates: -
Products: -

pro-hepatocyte growth factor + H2O

proprotein convertase subtilisin/kexin type 5 precursor + H2O

Substrates: residues 371-375
Products: -

proteinase-activated receptor 2 zymogen + H2O

mature proteinase-activated receptor 2 + ?

Substrates: -
Products: -

serin protease inhibitor Kazal-type 5 precursor + H2O

Substrates: residues 1034-1037
Products: -

vascular endothelial growth factor receptor 3 precursor + H2O

Substrates: residues 1126-1130
Products: -

villin-like protein + H2O

Substrates: residues 61-65
Products: -

additional information

4 entries

additional information

Substrates: crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
Products: -

additional information

Substrates: crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
Products: -

additional information

Substrates: the enzyme activates the proteinase-activated receptor 2 recombinnatly expressed in rat and in human cells
Products: -

additional information

Substrates: the enzyme activates the proteinase-activated receptor 2 recombinnatly expressed in rat and in human cells
Products: -

show all columns Go to Inhibitor Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

ACTG9

synthetic inhibitor

alpha1-Aantichymotrypsin

forms covalent complex with hK14

668566

alpha1-antitrypsin

forms covalent complex with hK14

668566

brazilin

natural compound derived from the wood of Caesalpinia sappan

770472

HAI-1A

no inhibition of KLK14 up to equimolar concentrations (5 nm) of enzyme and inhibitor. As the reaction shifts to containing excess inhibitor, KLK14 is mildly inhibited, with inhibition of 35% obtained when HAI-1A is present at 10fold excess over protease

HAI-1B

no inhibition of KLK14 up to equimolar concentrations (5 nm) of enzyme and inhibitor. As the reaction shifts to containing excess inhibitor, KLK14 is mildly inhibited, with inhibition of 26% obtained when HAI-1B is present at 10fold excess over protease

lympho-epithelial Kazal type inhibitor fragment D5

lympho-epithelial Kazal type inhibitor fragment D8-D11

lympho-epithelial Kazal type inhibitor fragment D9-D15

Spink6

i.e. serine protease inhibitor Kazal type 6. Selective inhibitor of kallikreins in the skin. Spink6 possesses only one typical Kazal domain. Its mRNA is expressed at low levels in several tissues and is induced during keratinocyte differentiation. Spink6 is expressed in the stratum granulosum of human skin at various anatomical localisations and in the skin appendages, including sebaceous glands and sweat glands. Spink6 expression is decreased in lesions of atopic dermatitis. Recombinant SPINK6 is inhibitory for KLK5, KLK7 and KLK14

vaspin

vaspin represents a multispecific serpin targeting the kallikrein proteases KLK7 and KLK14

Zn2+

semenogelins are able to reverse KLK14 inhibition by Zn2+

additional information

not inhibited by lympho-epithelial Kazal type inhibitor fragments D1 and D6

Go to Disease Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Adenocarcinoma

High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse.

Adenoma

Parallel overexpression and clinical significance of kallikrein-related peptidases 7 and 14 (KLK7 KLK14) in colon cancer.

23224034

Adenoma, Pleomorphic

Human kallikrein 14 (KLK14) expression in salivary gland tumors.

Breast Neoplasms

Enzymatic profiling of human kallikrein 14 using phage-display substrate technology.

15843175

Breast Neoplasms

Expression and enzymatic characterization of recombinant human kallikrein 14.

18217483

Breast Neoplasms

Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status.

16434994

Breast Neoplasms

Human kallikrein 14: a new potential biomarker for ovarian and breast cancer.

14695222

Breast Neoplasms

MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer.

29509840

Breast Neoplasms

Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis.

Breast Neoplasms

Quantitative expression analysis and study of the novel human kallikrein-related peptidase 14 gene (KLK14) in malignant and benign breast tissues.

21057706

Breast Neoplasms

Significant alterations in the expression pattern of kallikrein-related peptidase genes KLK4, KLK5 and KLK14 after treatment of breast cancer cells with the chemotherapeutic agents epirubicin, docetaxel and methotrexate.

23086576

Breast Neoplasms

The canine kallikrein-related peptidase 14: structural characterization, alternative splicing and differential expression in mammary cancer.

19619623

Carcinogenesis

Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.

Carcinogenesis

Kallikrein-related peptidase signaling in colon carcinoma cells: Targeting proteinase-activated receptors (PARs).

22148895

Carcinogenesis

Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.

22505523

Carcinogenesis

Parallel overexpression and clinical significance of kallikrein-related peptidases 7 and 14 (KLK7 KLK14) in colon cancer.

23224034

Carcinoma

Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.

29707153

Carcinoma

Effects of kallikrein-related peptidase 14 gene inhibition by small interfering RNA in ovarian carcinoma cells.

21993700

Carcinoma

Human kallikrein 14 (KLK14) expression in salivary gland tumors.

Carcinoma

Quantitative expression analysis and study of the novel human kallikrein-related peptidase 14 gene (KLK14) in malignant and benign breast tissues.

21057706

Carcinoma, Adenoid Cystic

Human kallikrein 14 (KLK14) expression in salivary gland tumors.

Carcinoma, Hepatocellular

Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.

29707153

Carcinoma, Mucoepidermoid

Human kallikrein 14 (KLK14) expression in salivary gland tumors.

Carcinoma, Renal Cell

Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.

29707153

Colonic Neoplasms

Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.

Colonic Neoplasms

Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer.

25153388

Colonic Neoplasms

Kallikrein-related peptidase signaling in colon carcinoma cells: Targeting proteinase-activated receptors (PARs).

22148895

Colonic Neoplasms

Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.

22505523

Dermatitis, Atopic

Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients.

17518992

Hereditary Complement Deficiency Diseases

Induction of complement c3a receptor responses by kallikrein-related peptidase 14.

24014879

Leukemia, Lymphocytic, Chronic, B-Cell

mRNA overexpression of kallikrein-related peptidase 14 (KLK14) is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients.

26351937

Lung Neoplasms

Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung.

18627302

Neoplasm Metastasis

The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer.

Neoplasm, Residual

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.

29546479

Neoplasms

A Suite of Activity-Based Probes To Dissect the KLK Activome in Drug-Resistant Prostate Cancer.

34085829

Neoplasms

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.

29546479

Neoplasms

Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.

11309303

Neoplasms

Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues.

12858357

Neoplasms

Effects of kallikrein-related peptidase 14 gene inhibition by small interfering RNA in ovarian carcinoma cells.

21993700

Neoplasms

Enzymatic profiling of human kallikrein 14 using phage-display substrate technology.

15843175

Neoplasms

Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14.

17110383

Neoplasms

Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status.

16434994

Neoplasms

High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse.

Neoplasms

Human kallikrein 14 (KLK14) expression in salivary gland tumors.

Neoplasms

Human kallikrein 14: a new potential biomarker for ovarian and breast cancer.

14695222

Neoplasms

Human tissue kallikreins and testicular cancer.

12752266

Neoplasms

In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.

27533117

Neoplasms

Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.

Neoplasms

Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.

Neoplasms

Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.

22505523

Neoplasms

KLK14 interactions with HAI-1 and HAI-2 serine protease inhibitors: A molecular dynamics and relative free-energy calculations study.

28817220

Neoplasms

Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14.

16704423

Neoplasms

Non-combinatorial library screening reveals subsite cooperativity and identifies new high efficiency substrates for kallikrein-related peptidase 14.

22148894

Neoplasms

Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14.

22505516

Neoplasms

Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases.

29218249

Neoplasms

Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis.

Neoplasms

Quantitative expression analysis and study of the novel human kallikrein-related peptidase 14 gene (KLK14) in malignant and benign breast tissues.

21057706

Neoplasms

Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung.

18627302

Neoplasms

Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer.

12645335

Neoplasms

The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness.

22505522

Neoplasms

The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer.

Neoplasms, Germ Cell and Embryonal

Human tissue kallikreins and testicular cancer.

12752266

Netherton Syndrome

Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.

Netherton Syndrome

Toward the first class of suicide inhibitors of kallikreins involved in skin diseases.

25489658

Ovarian Neoplasms

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.

29546479

Ovarian Neoplasms

Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.

11309303

Ovarian Neoplasms

Effects of kallikrein-related peptidase 14 gene inhibition by small interfering RNA in ovarian carcinoma cells.

21993700

Ovarian Neoplasms

Human kallikrein 14: a new potential biomarker for ovarian and breast cancer.

14695222

Ovarian Neoplasms

Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis.

Ovarian Neoplasms

Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer.

12645335

Prostatic Neoplasms

Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues.

12858357

Prostatic Neoplasms

Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14.

17110383

Prostatic Neoplasms

High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse.

Prostatic Neoplasms

In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.

27533117

Prostatic Neoplasms

Kallikrein gene family as biomarkers for recurrent prostate cancer.

33150763

Prostatic Neoplasms

Kallikreins are involved in an miRNA network that contributes to prostate cancer progression.

25153383

Prostatic Neoplasms

KLK14 interactions with HAI-1 and HAI-2 serine protease inhibitors: A molecular dynamics and relative free-energy calculations study.

28817220

Prostatic Neoplasms

MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer.

29509840

Prostatic Neoplasms

The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness.

22505522

Prostatic Neoplasms

The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer.

Psoriasis

Aberrant human tissue kallikrein levels in the stratum corneum and serum of patients with psoriasis: dependence on phenotype, severity and therapy.

17459012

Skin Diseases

Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.

Skin Diseases

Toward the first class of suicide inhibitors of kallikreins involved in skin diseases.

25489658

Skin Diseases

Transgenic kallikrein 14 mice display major hair shaft defects associated with desmoglein 3 and 4 degradation, abnormal epidermal differentiation and Il-36 signature.

32169475

Testicular Neoplasms

Human tissue kallikreins and testicular cancer.

12752266

Testicular Neoplasms

Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis.

Entries 1 - 20 of 86

Show complete table

show all columns Go to KM Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.431

GSLR-4-nitroanilide

pH 8.0, 37°C

0.75

L-Pro-Phe-Arg-p-nitroanilide

in 0.1 M Tris, 0.5 M NaCl, pH 8

0.258

QAR-7-amido-4-methylcoumarin

37°C, pH 8.8

1.675

tosyl-Gly-L-Pro-L-Arg-4-nitroanilide

pH 8.0, temperature not specified in the publication

0.318

VGSLR-4-nitroanilide

pH 8.0, 37°C

0.034

WASR-4-nitroanilide

pH 8.0, 37°C

0.052

WAVR-4-nitroanilide

pH 8.0, 37°C

0.0305

WVSR-4-nitroanilide

pH 8.0, 37°C

0.043

YAAR-4-nitroanilide

pH 8.0, 37°C

0.017

YANR-4-nitroanilide

pH 8.0, 37°C

0.022

YASR-4-nitroanilide

pH 8.0, 37°C

0.045

YAVR-4-nitroanilide

pH 8.0, 37°C

show all columns Go to Turnover Number Search

0.025

YVSR-4-nitroanilide

pH 8.0, 37°C

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

15.8

GSLR-4-nitroanilide

pH 8.0, 37°C

12.1

QAR-7-amido-4-methylcoumarin

37°C, pH 8.8

44.03

VGSLR-4-nitroanilide

pH 8.0, 37°C

63.24

WASR-4-nitroanilide

pH 8.0, 37°C

97.31

WAVR-4-nitroanilide

pH 8.0, 37°C

42.91

WVSR-4-nitroanilide

pH 8.0, 37°C

69.37

YAAR-4-nitroanilide

pH 8.0, 37°C

53.04

YANR-4-nitroanilide

pH 8.0, 37°C

83.85

YASR-4-nitroanilide

pH 8.0, 37°C

93.33

YAVR-4-nitroanilide

pH 8.0, 37°C

show all columns Go to kcat/KM Value Search

34.57

YVSR-4-nitroanilide

pH 8.0, 37°C

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

36.6

GSLR-4-nitroanilide

pH 8.0, 37°C

46.9

QAR-7-amido-4-methylcoumarin

37°C, pH 8.8

138.3

VGSLR-4-nitroanilide

pH 8.0, 37°C

1880

WASR-4-nitroanilide

pH 8.0, 37°C

1888

WAVR-4-nitroanilide

pH 8.0, 37°C

1408

WVSR-4-nitroanilide

pH 8.0, 37°C

1609

YAAR-4-nitroanilide

pH 8.0, 37°C

3161

YANR-4-nitroanilide

pH 8.0, 37°C

3806

YASR-4-nitroanilide

pH 8.0, 37°C

2074

YAVR-4-nitroanilide

pH 8.0, 37°C

show all columns Go to Ki Value Search

1370

YVSR-4-nitroanilide

pH 8.0, 37°C

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0000176

lympho-epithelial Kazal type inhibitor fragment D5

0.0000031

lympho-epithelial Kazal type inhibitor fragment D8-11

0.0000523

lympho-epithelial Kazal type inhibitor fragment D9-15

0.0000005

Spink6

pH 8.0, temperature not specified in the publication

show all columns Go to IC50 Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0146

brazilin

Homo sapiens

pH not specified in the publication, temperature not specified in the publication

770472

show all columns Go to pH Optimum Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

assay at

8.8

assay at

show all columns Go to Temperature Optimum Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

TEMPERATURE OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

assay at

show all columns Go to Organism Search

only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

C7T1J3

UniProt

brenda

brenda

brenda

SwissProt

brenda

brenda

SwissProt

brenda

695234, 707613, 708757, 709135, 717068

brenda

731395, 731398, 752884, 752891, 753299, 770472, 772193, 774367

SwissProt

brenda

gene KLK14 or KLK-L6

395498, 647376

SwissProt

brenda

patients with invasive breast cancer

668103

brenda

show all columns Go to Source Tissue Search

only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

brenda

brenda

KLK14 expression significantly higher compared to normal breast tissues

668103

brenda

colon adenocarcinoma cell

brenda

brenda

brenda

brenda

of normal bronchus

brenda

benign and malignant glandular epithelium

brenda

KLK14 transits via endoplasmic reticulum before being specifically localized to the lamellipodia and filopodia of prostate cancer cells

brenda

brenda

brenda

brenda

brenda

brenda

non-small cell lung cancer cell

prostate adenocarcinoma cell

KLK13 and KLK14 cannot be considered as specific markers for non-small-cell lung cancer

brenda

brenda

brenda

brenda

brenda

brenda

brenda

brenda

brenda

additional information

brenda

brenda

brenda

KLK14 expression is significantly lower in individuals with clinically delayed liquefaction. Crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen

brenda

brenda

brenda

additional information

C7T1J3

the classical form of KLK14 and splice variant 3 are almost ubiquitously expressed in both normal and neoplastic tissues. Splice variant 1 is predominantly detected in normal tissues. The classical form and splice variants 1 and 2 exhibit lower expression levels in tumor compared to normal tissues. All encoded protein products of the splice variants are predicted to be truncated and catalytically inactive

brenda

additional information

brenda

additional information

KLK14 is absent in normal epithelia

brenda

show all columns Go to Localization Search

only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

LOCALIZATION

ORGANISM

UNIPROT

COMMENTARY

GeneOntology No.

LITERATURE

SOURCE

cell surface

substrate MMP14 is processed on the cell surface by KLK14

brenda

KLK14 transits via endoplasmic reticulum before being specifically localized to the lamellipodia and filopodia of prostate cancer cells

brenda

brenda

brenda

Highest Expressing Human Cell Lines

Filter by:

Cell Line Links

Gene Links

show all columns Go to General Information Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

aberrant enzyme activity is associated with inflammatory skin diseases such as Netherton syndrome but also with various serious forms of cancer

metabolism

both KLK14 and trypsin are able to activate MAP kinase signalling in the human HEK cells as does the PAR-activating peptide, while KLK8 does not

physiological function

5 entries

additional information

enzyme structure homology modelling using crystal structure, PDB 2BDG, overview

physiological function

KLK14 (0.0001 mM) induces increases in intracellular Ca2+ in HT-29 cells. KLK14 induces significant extracellular signal-regulated kinases 1 and 2 phosphorylation and HT-29 cell proliferation, presumably by activating proteinase-activated receptor-2

physiological function

human enzyme can activate rat and human proteinase-activated receptor 2, PAR2, calcium signalling, and the enzyme stimulates human PAR2 clustering and internalization

physiological function

important protease in skin desquamation

physiological function

the enzyme regulates the components of the hepatocyte growth factor/Met axis, pro-hepatocyte growth factor and hepatocyte growth factorF-activator inhibitor 1A and 1B

physiological function

KLK14 is involved in regulation of interleukin 32, midkine, SRY-Box 9, mitogen-activated protein kinase 1 and interleukin 1 receptor pathways, and in the regulation of cellular migration. KLK14 overexpression modifies the growth pattern of LNCaP cells with the formation of a trabecular network

Go to AA Sequence and Transmembrane Helices SearchGo to Localization Prediction

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

Q9P0G3 pBLAST

KLK14_HUMAN

267

29122

Swiss-Prot

Show Sequence

show all columns Go to Molecular Weight Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

25000

casein zymography

show all columns Go to Posttranslational Modification Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

glycoprotein

the lower catalytic efficiency observed against a peptide substrate for insect cell expressed KLK14, compared with the previously reported yeast expressed protease, is possibly due to N-glycosylation present on the former but not the latter

proteolytic modification

pro-kallikrein 14 iss activated with thermolysin

show all columns Go to Protein Variants Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

I155N

C7T1J3

natural polymorphism

Go to Purification (commentary) Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

cation exchange chromatography

Go to Cloned (commentary) Search

Superdex gel filtration and reversed-phase liquid chromatography

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

DNA sequence determination and analysis

expression in Pichia pastoris

expression in Spodoptera frugiperda Sf9 cells

expression of proKLK14 with a codon usage optimized for Leishmania tarentolae

gene KLK14, recombinant expression in Spodoptera frugiperda Sf9 insect cells

Go to Expression Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

EXPRESSION

ORGANISM

UNIPROT

LITERATURE

in addition to the classical form of the gene, five splice variants were identified. The splicing events involve 5'-truncation or complete elimination of exon 4 and/or retention of intron I. All encoded protein products of the splice variants are predicted to be truncated and catalytically inactive

C7T1J3

show all columns Go to Application Search

KLK14 expression is elevated in advanced prostate cancer, and particularly in metastasis, KLK14 levels are decreased in prostate cancer tissues from patients responsive to neoadjuvant therapy, and KLK14 expression reoccurs in patients who developed castrate-resistant prostate cancer

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

diagnostics

mRNA overexpression of kallikrein 14 is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients

753299

medicine

4 entries

medicine

KLK14 has the prognostic potential to recognize prostate cancer patients at higher risk of disease recurrence after radical prostatectomy. As an independent factor, KLK14 is expected to supplement postoperative prostate-specific antigen values for a more precise prognosis

695234

medicine

normal salivary glands, pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma show strong expression of KLK14 in ductal and non-ductal cells. Both pleomorphic adenoma and adenoid cystic carcinoma show higher KLK14 levels than normal glands and mucoepidermoid carcinoma tissues. There are no statistically significant associations between levels of KLK14 and clinical parameters

708757

medicine

study on the clinical value of seminal kallikreins in the evaluation of semen quality and differential diagnosis and etiology of abnormal liquefaction and/or viscosity. Combination of KLK2, 3, 13, and 14 and KLK1, 2, 5, 6, 7, 8, 10, 13, and 14 shows very strong discriminatory potential for semen liquefaction and viscosity, respectively. Liquefaction state is associated with several parameters of sperm motility. KLK14 is differentially expressed in asthenospermic cases

707613

medicine

KLK14 and its receptor proteinase-activated receptor-2 represent therapeutic targets for colon tumorigenesis

top print hide References Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

395498

Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.

The SWISS-PROT protein knowledgebase and its supplement TrEMBL

Nucleic Acids Res.

365-370

2003

Homo sapiens (Q9P0G3)

12520024

brenda

Hooper, J.D.; Bui, L.T.; Rae, F.K.; Harvey, T.J.; Myers, S.A; Ashworth, L.K.; Clements, J.A.

Identification and characterization of KLK14, novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle

Genomics

117-122

2001

Homo sapiens (Q9P0G3), Homo sapiens

11352573

brenda

Felber, L.M.; Borgono, C.A.; Cloutier, S.M.; Kuendig, C.; Kishi, T.; Ribeiro Chagas, J.; Jichlinski, P.; Gygi, C.M.; Leisinger, H.J.; Diamandis, E.P.; Deperthes, D.

Enzymatic profiling of human kallikrein 14 using phage-display substrate technology

Biol. Chem.

386

291-298

2005

Homo sapiens

15843175

brenda

668103

Fritzsche, F.; Gansukh, T.; Borgono, C.A.; Burkhardt, M.; Pahl, S.; Mayordomo, E.; Winzer, K.J.; Weichert, W.; Denkert, C.; Jung, K.; Stephan, C.; Dietel, M.; Diamandis, E.P.; Dahl, E.; Kristiansen, G.

Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status

Br. J. Cancer

540-547

2006

Homo sapiens

16434994

brenda

668566

Felber, L.M.; Kuendig, C.; Borgono, C.A.; Chagas, J.R.; Tasinato, A.; Jichlinski, P.; Gygi, C.M.; Leisinger, H.J.; Diamandis, E.P.; Deperthes, D.; Cloutier, S.M.

Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14

FEBS J.

273

2505-2514

2006

Homo sapiens

16704423

brenda

678525

Stefansson, K.; Brattsand, M.; Ny, A.; Glas, B.; Egelrud, T.

Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum

Biol. Chem.

387

761-768

2006

Homo sapiens (Q9P0G3), Homo sapiens

16800737

brenda

Emami, N.; Diamandis, E.P.

Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin

J. Biol. Chem.

283

3031-3041

2008

Homo sapiens (Q9P0G3), Homo sapiens

18056261

brenda

Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J.P.; Leonardsson, G.; Hovnanian, A.

LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction

Mol. Biol. Cell

3607-3619

2007

Homo sapiens

17596512

brenda

682813

Fernando, S.C.; Buck, J.S.; Ashworth, M.D.; Ross, J.W.; Geisert, R.D.; DeSilva, U.

Porcine endometrial and conceptus tissue kallikrein 1, 4, 11, and 14 gene expression

Reproduction

132

939-947

2006

Sus scrofa

17127754

brenda

691155

Planque, C.; Blechet, C.; Ayadi-Kaddour, A.; Heuze-Vourch, N.; Dumont, P.; Guyetant, S.; Diamandis, E.P.; El Mezni, F.; Courty, Y.

Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung

Biol. Chem.

389

781-786

2008

Homo sapiens (Q9P0G3), Homo sapiens

18627302

brenda

Emami, N.; Deperthes, D.; Malm, J.; Diamandis, E.P.

Major role of human KLK14 in seminal clot liquefaction

J. Biol. Chem.

283

19561-19569

2008

Homo sapiens (Q9P0G3), Homo sapiens

18482984

brenda

695234

Rabien, A.; Fritzsche, F.; Jung, M.; Diamandis, E.P.; Loening, S.A.; Dietel, M.; Jung, K.; Stephan, C.; Kristiansen, G.

High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse

Tumour Biol.

1-8

2008

Homo sapiens

brenda

707613

Emami, N.; Scorilas, A.; Soosaipillai, A.; Earle, T.; Mullen, B.; Diamandis, E.P.

Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility

Biol. Chem.

390

921-929

2009

Homo sapiens

19558318

brenda

Angelopoulou, K.; Prassas, I.; Yousef, G.M.

The canine kallikrein-related peptidase 14: structural characterization, alternative splicing and differential expression in mammary cancer

Gene

446

68-74

2009

Canis lupus familiaris (C7T1J3), Canis lupus familiaris

19619623

brenda

708757

Hashem, N.N.; Mara, T.W.; Mohamed, M.; Zhang, I.; Fung, K.; Kwan, K.F.; Daley, T.D.; Diamandis, E.P.; Darling, M.R.

Human kallikrein 14 (KLK14) expression in salivary gland tumors

Int. J. Biol. Markers

32-37

2010

Homo sapiens

brenda

Meyer-Hoffert, U.; Wu, Z.; Kantyka, T.; Fischer, J.; Latendorf, T.; Hansmann, B.; Bartels, J.; He, Y.; Glaeser, R.; Schroeder, J.M.

Isolation of Spink6 in human skin: a selective inhibitor of kallikrein-related peptidases

J. Biol. Chem.

285

32174-32181

2010

Homo sapiens

20667819

brenda

Gratio, V.; Loriot, C.; Virca, G.D.; Oikonomopoulou, K.; Walker, F.; Diamandis, E.P.; Hollenberg, M.D.; Darmoul, D.

Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells

Am. J. Pathol.

179

2625-2636

2011

Homo sapiens

brenda

de Veer, S.J.; Swedberg, J.E.; Parker, E.A.; Harris, J.M.

Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14

Biol. Chem.

393

331-341

2012

Homo sapiens (Q9P0G3)

22505516

brenda

Ramachandran, R.; Eissa, A.; Mihara, K.; Oikonomopoulou, K.; Saifeddine, M.; Renaux, B.; Diamandis, E.; Hollenberg, M.D.

Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14

Biol. Chem.

393

421-427

2012

Homo sapiens (Q9P0G3), Homo sapiens

22505524

brenda

Reid, J.C.; Bennett, N.C.; Stephens, C.R.; Carroll, M.L.; Magdolen, V.; Clements, J.A.; Hooper, J.D.

In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B

Biol. Chem.

397

1299-1305

2016

Homo sapiens (Q9P0G3)

27533117

brenda

Ulbricht, D.; Tindall, C.A.; Oertwig, K.; Hanke, S.; Straeter, N.; Heiker, J.T.

Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin

Biol. Chem.

399

1079-1084

2018

Homo sapiens (Q9P0G3)

brenda

753299

Kontos, C.K.; Adamopoulos, P.G.; Papageorgiou, S.G.; Pappa, V.; Scorilas, A.

mRNA overexpression of kallikrein-related peptidase 14 (KLK14) is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients

Clin. Chem. Lab. Med.

315-324

2016

Homo sapiens (Q9P0G3), Homo sapiens

26351937

brenda

770472

Di Paolo, C.T.; Filippou, P.S.; Yu, Y.; Poda, G.; Diamandis, E.P.; Prassas, I.

Screening of chemical libraries in pursuit of kallikrein-5 specific inhibitors for the treatment of inflammatory dermatoses

Clin. Chem. Lab. Med.

1737-1743

2019

Homo sapiens (Q9P0G3)

31129650

brenda

Falkowski, K.; Bielecka, E.; Thgersen, I.B.; Bochenska, O.; Plaza, K.; Kalinska, M.; Sasiadek, L.; Magoch, M.; Pecak, A.; Wisniewska, M.; Gruba, N.; Wysocka, M.; Wojtysiak, A.; Brzezinska-Bodal, M.; Sychowska, K.; Pejkovska, A.; Rehders, M.; Butler, G.; Overall, C.M.; Brix, K.; Dubin, G.; Lesner, A.

Kallikrein-related peptidase 14 activates zymogens of membrane type matrix metalloproteinases (MT-MMPs) - a CleavEx based analysis

Int. J. Mol. Sci.

4383

2020

Homo sapiens (Q9P0G3)

32575583

brenda

Kryza, T.; Bock, N.; Lovell, S.; Rockstroh, A.; Lehman, M.L.; Lesner, A.; Panchadsaram, J.; Silva, L.M.; Srinivasan, S.; Snell, C.E.; Williams, E.D.; Fazli, L.; Gleave, M.; Batra, J.; Nelson, C.; Tate, E.W.; Harris, J.; Hooper, J.D.; Clements, J.A.

The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer

Mol. Oncol.

105-128

2020

Homo sapiens (Q9P0G3)