Reference on EC 3.4.21.B26 - proprotein convertase 5
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Basak, A.; Zhong, M.; Munzer, J.S.; Chretien, M.; Seidah, N.G.
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides
Biochem. J.
353
537-545
2001
Mus musculus
De Strooper, B.; Creemers, J.W.; Moechars, D.; Huylebroeck, D.; Van De Ven, W.J.; Van Leuven, F.; Van den Berghe, H.
Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes
Biochim. Biophys. Acta
1246
185-188
1995
Mus musculus
De Bie, I.; Marcinkiewicz, M.; Malide, D.; Lazure, C.; Nakayama, K.; Bendayan, M.; Seidah, N.G.
The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments
J. Cell. Biol.
135
1261-1275
1996
Mus musculus
Stawowy, P.; Kallisch, H.; Veinot, J.P.; Kilimnik, A.; Prichett, W.; Goetze, S.; Seidah, N.G.; Chretien, M.; Fleck, E.; Graf, K.
Endoproteolytic activation of av integrin by proprotein convertase PC5 is required for Vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling
Circulation
109
770-776
2004
Rattus norvegicus (P41413), Homo sapiens (Q92824)
Tang, M.; Mikhailik, A.; Pauli, I.; Giudice, L.C.; Fazelabas, A.T.; Tulac, S.; Carson, D.D.; Kaufman, D.G.; Barbier, C.; Creemers, J.W.; Tabibzadeh, S.
Decidual differentiation of stromal cells promotes proprotein convertase 5/6 expression and lefty processing
Endocrinology
146
5313-5320
2005
Mus musculus (Q04592), Mus musculus
Seidah, N.G.; Chretien, M.
Proprotein convertase 5
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
2
1874-1877
2004
Homo sapiens, Mus musculus, Rattus norvegicus
-
Okada, H.; Nie, G.; Salamonsen, L.A.
Requirement for proprotein convertase 5/6 during decidualization of human endometrial stromal cells in vitro
J. Clin. Endocrinol. Metab.
90
1028-1034
2005
Homo sapiens (Q92824), Homo sapiens
Stawowy Philip, S.P.; Fleck Eckar, F.E.
Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels
J. Mol. Med.
83
865-875
2005
Rattus norvegicus (P41413), Homo sapiens (Q92824)
Essalmani, R.; Hamelin, J.; Marcinkiewicz, J.; Chamberland, A.; Mbikay, M.; Chretien, M.; Seidah, N.G.; Prat, A.
Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse
Mol. Cell. Biol.
26
354-361
2006
Mus musculus, Homo sapiens (Q92824)
Stein, J.; Shah, R.; Steiner, D.F.; Dey, A.
RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor
Biochem. J.
400
209-215
2006
Mus musculus (Q04592)
Dikeakos, J.D.; Mercure, C.; Lacombe, M.; Seidah, N.G.; Reudelhuber, T.L.
PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism
FEBS J.
274
4094-4102
2007
Mus musculus
Seidah, N.G.; Mayer, G.; Zaid, A.; Rousselet, E.; Nassoury, N.; Poirier, S.; Essalmani, R.; Prat, A.
The activation and physiological functions of the proprotein convertases
Int. J. Biochem. Cell Biol.
40
1111-1125
2008
Mus musculus (Q04592)
Benjannet, S.; Rhainds, D.; Hamelin, J.; Nassoury, N.; Seidah, N.G.
The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications
J. Biol. Chem.
281
30561-30572
2006
Homo sapiens (Q92824), Homo sapiens
Mayer, G.; Hamelin, J.; Asselin, M.; Pasquato, A.; Marcinkiewicz, E.; Tang, M.; Tabibzadeh, S.; Seidah, N.G.
The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates
J. Biol. Chem.
283
2373-2384
2008
Mus musculus (Q04592)
Fugere, M.; Appel, J.; Houghten, R.A.; Lindberg, I.; Day, R.
Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences
Mol. Pharmacol.
71
323-332
2007
Homo sapiens
Reynolds Nicole , R.N.; Blum Aliss, B.A.; Kitagawa Kouk, K.K.; Beinfeld, M.C.
Inhibition of PC5 expression decreases CCK secretion and increases PC2 expression
Peptides
27
901-904
2006
Mus musculus (Q04592), Mus musculus
Padua, M.B.; Hansen, P.J.
Regulation of DNA synthesis and the cell cycle in human prostate cancer cells and lymphocytes by ovine uterine serpin
BMC Cell Biol.
9
5
2008
Mus musculus (Q04592)
Remacle, A.G.; Shiryaev, S.A.; Oh, E.S.; Cieplak, P.; Srinivasan, A.; Wei, G.; Liddington, R.C.; Ratnikov, B.I.; Parent, A.; Desjardins, R.; Day, R.; Smith, J.W.; Lebl, M.; Strongin, A.Y.
Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
J. Biol. Chem.
283
20897-20906
2008
Homo sapiens
Essalmani, R.; Zaid, A.; Marcinkiewicz, J.; Chamberland, A.; Pasquato, A.; Seidah, N.G.; Prat, A.
In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate
Proc. Natl. Acad. Sci. USA
105
5750-5755
2008
Mus musculus (Q04592), Mus musculus
Xiao, Y.; Chen, G.; Richard, J.; Rougeau, N.; Li, H.; Seidah, N.G.; Cohen, E.A.
Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases
Virology
372
384-397
2008
Mus musculus (Q04592)
Fuller, J.A.; Brun-Zinkernagel, A.M.; Clark, A.F.; Wordinger, R.J.
Subtilisin-like proprotein convertase expression, localization, and activation in the human retina and optic nerve head
Invest. Ophthalmol. Vis. Sci.
50
5759-5768
2009
Homo sapiens
Sun, X.; Essalmani, R.; Seidah, N.G.; Prat, A.
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model
Mol. Cancer
8
73
2009
Mus musculus
Kim, Y.S.; Jung, J.A.; Kim, H.J.; Ahn, Y.H.; Yoo, J.S.; Oh, S.; Cho, C.; Yoo, H.S.; Ko, J.H.
Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5
Biochem. Biophys. Res. Commun.
404
96-102
2011
Homo sapiens
Fritzsche, J.; Stawowy, P.
Time for endothelial cell proprotein convertase PC5/6 in cardiovascular medicine?
J. Mol. Med.
89
1061-1063
2011
Mus musculus
Lee, S.N.; Lee, D.H.; Lee, M.G.; Yoon, J.H.
Proprotein convertase 5/6A is associated with BMP-2-induced squamous cell differentiation
Am. J. Respir. Cell Mol. Biol.
52
749-761
2014
Homo sapiens (Q92824), Homo sapiens
Heng, S.; Dynon, K.; Li, Y.; Edgell, T.; Walton, K.; Rombauts, L.J.; Vollenhoven, B.; Nie, G.
Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity
Anal. Biochem.
475
14-21
2015
Homo sapiens (Q92824), Homo sapiens
Paule, S.; Aljofan, M.; Simon, C.; Rombauts, L.J.; Nie, G.
Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6
Hum. Reprod.
27
2766-2774
2012
Homo sapiens (Q92824), Homo sapiens
Paule, S.; Nebl, T.; Webb, A.; Vollenhoven, B.; Rombauts, L.; Nie, G.
Proprotein convertase 5/6 cleaves platelet-derived growth factor A in the human endometrium in preparation for embryo implantation
Mol. Hum. Reprod.
21
262-270
2014
Homo sapiens (Q92824), Homo sapiens
Lee, S.; Lee, D.; Lee, M.; Yoon, J.
Proprotein convertase 5/6A is associated with bone morphogenetic protein-2-induced squamous cell differentiation
Am. J. Respir. Cell Mol. Biol.
52
749-761
2015
Homo sapiens (Q92824), Homo sapiens
Hoac, B.; Susan-Resiga, D.; Essalmani, R.; Marcinkiweicz, E.; Seidah, N.G.; McKee, M.D.
Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone
Bone
107
45-55
2018
Mus musculus (Q04592)
Heng, S.; Paule, S.G.; Li, Y.; Rombauts, L.J.; Vollenhoven, B.; Salamonsen, L.A.; Nie, G.
Posttranslational removal of alpha-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women
FASEB J.
29
4011-4022
2015
Homo sapiens (Q92824), Homo sapiens
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