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3 acetyl-Pro-Ala-Phe-Phe-NH2 + H2O
acetyl-Pro-Ala-Phe-Phe + NH3 + acetyl-Pro-Ala + Phe-Phe-NH2 + acetyl-Pro-Ala-Phe + Phe-NH2
-
hydrolyzed at the Ala-Phe, the Phe-Phe and the Phe-NH2 bonds
-
-
?
acetyl-Ala-Ala-Tyr-4-methylcoumarin 7-amide + H2O
acetyl-Ala-Ala-Tyr + 7-amino-4-methylcoumarin
-
-
-
-
?
Acetyl-Pro-Ala-Ala-Phe-NH2 + H2O
?
-
-
-
-
?
Acetyl-Pro-Ala-Gly-Phe-NH2 + H2O
?
-
split at amide bond as well as at the Ala-Gly bond
-
-
?
Acetyl-Pro-Ala-Leu-Phe-NH2 + H2O
Acetyl-Pro-Ala-Leu-Phe-OH + NH3
-
hydrolyzed at the amide bond only
-
-
?
Acetyl-Pro-Ala-Pro-Phe-Leu-NH2 + H2O
Acetyl-Pro-Ala-Pro-Phe + Leu-NH2
-
-
-
?
Acetyl-Pro-Ala-Pro-Phe-NH2 + H2O
Acetyl-Pro-Ala-Pro-Phe-OH + NH3
Acetyl-Pro-Ala-Pro-Phe-Tyr-NH2 + H2O
Acetyl-Pro-Ala-Pro-Phe + Tyr-NH2
-
-
-
?
Acetyl-Pro-Ala-Pro-Trp-NH2 + H2O
Acetyl-Pro-Ala-Pro-Trp-OH + NH3
-
-
-
?
Acetyl-Pro-Ala-Pro-Tyr-NH2 + H2O
Acetyl-Pro-Ala-Pro-Tyr-OH + NH3
-
-
-
?
Peptide + H2O
Hydrolyzed peptide + H2O
-
interacts favorably with peptides with hydrophobic non-aromatic, P2 amino acid residues, leucine being optimal
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
Succinyl-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
succinyl-Ala-Ala-Pro-X-4-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ala-Ala-Pro-X-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
additional information
?
-
-
model of serine protease catalytic tetrahedral intermediates
-
-
?
Acetyl-Pro-Ala-Pro-Phe-NH2 + H2O
Acetyl-Pro-Ala-Pro-Phe-OH + NH3
-
-
-
?
Acetyl-Pro-Ala-Pro-Phe-NH2 + H2O
Acetyl-Pro-Ala-Pro-Phe-OH + NH3
-
hydrolyzed at the amide bond only
-
?
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Acquired Immunodeficiency Syndrome
HIV protease: a novel chemotherapeutic target for AIDS.
Acquired Immunodeficiency Syndrome
Memapsin 2 (Beta-Secretase) Inhibitor Drug, between Fantasy and Reality.
Adenocarcinoma
[Distant metastases to maxillary sinus from an unknown lung adenocarcinoma: a cases report].
African Swine Fever
African swine fever virus protease, a new viral member of the SUMO-1-specific protease family.
Alzheimer Disease
Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.
Androgen-Insensitivity Syndrome
Immunocytochemical localization of nerve growth factor, submandibular glands of Tfm/Y mice.
Anemia, Hemolytic
A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient.
Atherosclerosis
Von Willebrand Factor and ADAMTS13 and long-term outcomes in patients undergoing percutaneous coronary intervention.
Breast Neoplasms
ADAMTS1-mediated targeting of TSP-1 by PPAR? suppresses migration and invasion of breast cancer cells.
Candidiasis
Evaluation of APR1 Gene Expression in Candida albicans Strains Isolated From Patients With Multiple Sclerosis.
Candidiasis
Increased expression of Candida albicans secretory proteinase, a putative virulence factor, in isolates from human immunodeficiency virus-positive patients.
Carotid Stenosis
Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis.
COVID-19
Potential SARS-COV preclinical (in vivo) compounds targeting COVID-19 main protease: a meta-analysis and molecular docking studies.
Dengue
Reaction mechanism of the dengue virus serine protease: a QM/MM study.
Encephalitis
Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: A P1-P4 SAR study.
Foot-and-Mouth Disease
Foot-and-mouth disease virus leader proteinase: a papain-like enzyme requiring an acidic environment in the active site.
Foot-and-Mouth Disease
Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs?
Foot-and-Mouth Disease
Structure of the foot-and-mouth disease virus leader protease: a papain-like fold adapted for self-processing and eIF4G recognition.
Glioblastoma
Site-1 protease, a novel metabolic target for glioblastoma.
Glomerulonephritis, IGA
Immunoglobulin A1 protease: a new therapeutic candidate for immunoglobulin A nephropathy.
Hemolytic-Uremic Syndrome
Intravenous gamma globulin for thrombotic microangiopathy of unknown etiology.
Hepatitis A
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors.
Hepatitis A
Polyprotein processing in cis and in trans by hepatitis A virus 3C protease cloned and expressed in Escherichia coli.
Hepatitis C
C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity.
Hepatitis C
Establishment of a simple assay in vitro for hepatitis C virus NS3 serine protease based on recombinant substrate and single-chain protease.
Hepatitis C
Thermodynamics of zinc binding to hepatitis C virus NS3 protease: A folding by binding event.
Hepatitis C
Unique Composite Active Site of the Hepatitis C Virus NS2-3 Protease: a New Opportunity for Antiviral Drug Design.
Hepatitis E
Expression and processing of the Hepatitis E virus ORF1 nonstructural polyprotein.
Hepatitis E
Hepatitis E virus (HEV) protease: a chymotrypsin-like enzyme that processes both non-structural (pORF1) and capsid (pORF2) protein.
Infections
CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B.
Infections
Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments.
Leprosy
Cloning, expression and characterisation of an HtrA-like serine protease produced in vivo by Mycobacterium leprae.
Leukemia
Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design.
Leukemia, T-Cell
Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design.
Leukemia, T-Cell
Substrates and inhibitors of human T-cell leukemia virus type 1 (HTLV-1) proteinase.
Leukemia, T-Cell
Total chemical synthesis of human T-cell leukemia virus type 1 protease via native chemical ligation.
Lung Neoplasms
[Distant metastases to maxillary sinus from an unknown lung adenocarcinoma: a cases report].
Lymphoma
The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.
Meningitis, Bacterial
Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters.
Multiple Sclerosis
The role of Candida albicans in the severity of multiple sclerosis.
Neoplasm Metastasis
[Distant metastases to maxillary sinus from an unknown lung adenocarcinoma: a cases report].
Neoplasms
ADAM17 in tumor associated leukocytes regulates inflammatory mediators and promotes mammary tumor formation.
Neoplasms
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Neoplasms
Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Neoplasms
iRhom2: An Emerging Adaptor Regulating Immunity and Disease.
Neoplasms
Lon protease: A key enzyme controlling mitochondrial bioenergetics in cancer.
Neoplasms
Ovarian tumor cells express a transmembrane serine protease: a potential candidate for early diagnosis and therapeutic intervention.
Neoplasms
Signal transduction pathways of membrane expression of proteinase 3 (PR-3) in human endothelial cells.
Neoplasms
[Establishment of a human lung squamous cell carcinoma cell line LK-17, and characterization of procoagulant, platelet aggregation and metastatic potential]
Neurologic Manifestations
A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient.
Periodontal Pocket
Analysis of the complement sensitivity of oral treponemes and the potential influence of FH binding, FH cleavage and dentilisin activity on the pathogenesis of periodontal disease.
Plague
Proteolysis of plasminogen activator inhibitor-1 by Yersinia pestis remodulates the host environment to promote virulence.
Pneumococcal Infections
Caseinolytic protease: a protein vaccine which could elicit serotype-independent protection against invasive pneumococcal infection.
Pneumococcal Infections
Immune response to capsular polysaccharide and surface proteins of Streptococcus pneumoniae in patients with invasive pneumococcal disease.
Porcine Reproductive and Respiratory Syndrome
Molecular cloning, expression, purification and crystallographic analysis of PRRSV 3CL protease.
Prostatic Neoplasms
Down-regulation of prostasin serine protease: a potential invasion suppressor in prostate cancer.
Purpura, Thrombotic Thrombocytopenic
An unusual case of rapidly progressive hyperbilirubinemia.
Purpura, Thrombotic Thrombocytopenic
Assays of von Willebrand factor-cleaving protease: a test for diagnosis of familial and acquired thrombotic thrombocytopenic purpura.
Purpura, Thrombotic Thrombocytopenic
Intravenous gamma globulin for thrombotic microangiopathy of unknown etiology.
Sepsis
Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C.
Starvation
Characteristics and functions of proteinase A and its inhibitors in yeast.
Starvation
Heritable activity: a prion that propagates by covalent autoactivation.
Starvation
Regulation of glutamine synthetase from Saccharomyces cerevisiae by repression, inactivation and proteolysis.
streptogrisin a deficiency
Isolation and characterization of a mouse protein C cDNA.
Thrombocytopenia
A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient.
Thrombosis
Balance between von Willebrand factor and ADAMTS13 following major partial hepatectomy.
Thrombosis
Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus.
Thrombosis
Isolation and characterization of a mouse protein C cDNA.
Thrombosis
Von Willebrand Factor and ADAMTS13 and long-term outcomes in patients undergoing percutaneous coronary intervention.
Thrombotic Microangiopathies
Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C.
Tuberculosis
Development of a point-of-care test to detect SARS-CoV-2 from saliva which combines a simple RNA extraction method with colorimetric reverse transcription loop-mediated isothermal amplification detection.
Tuberculosis
Effect of HIV protease inhibitors and Orlistat on mycobacterial ES-31 serine protease, a potential drug target in Mycobacterium tuberculosis.
Vaccinia
Analysis of vaccinia virus temperature-sensitive I7L mutants reveals two potential functional domains.
Vibrio Infections
Presence of a lethal protease in the extracellular products of Vibrio splendidus-Vibrio lentus related strains.
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Ardelt, W.; Laskowski, M.
Turkey ovomucoid third domain inhibits eight different serine proteinases of varied specificity on the same ...Leu18-Glu19 ... reactive site
Biochemistry
24
5313-5320
1985
Streptomyces griseus
brenda
Henderson, G.; Krygsman, P.; Liu, C.J.; Davey, C.C.; Malek, L.T.
Characterization and structure of genes for proteases A and B from Streptomyces griseus
J. Bacteriol.
169
3778-3784
1987
Streptomyces griseus
brenda
James, M.N.G.; Sielecki, A.R.; Brayer, G.D.; Delbaere, L.T.J.
Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1.8 A resolution. A model for serine protease catalysis
J. Mol. Biol.
144
43-88
1980
Streptomyces griseus
brenda
Sielecki, A.R.; Hendrickson, W.A.; Broughton, C.G.; Delbaere, L.T.J.; Brayer, G.D.; James, M.N.G.
Protein structure refinement: Streptomyces griseus serine protease A at 1.8 A resolution
J. Mol. Biol.
134
781-804
1979
Streptomyces griseus
brenda
Delbaere, L.T.J.; Brayer, G.D.
The 1.8 A structure of the complex between chymostatin and Streptomyces griseus protease A. A model for serine protease catalytic tetrahedral intermediates
J. Mol. Biol.
183
89-103
1985
Streptomyces griseus
brenda
Bauer, C.A.
Active centers of alpha-chymotrypsin and of Streptomyces griseus proteases 1 and 3. S2-P2 enzyme-substrate interactions
Eur. J. Biochem.
105
565-570
1980
Streptomyces griseus
brenda
Delbaere, L.T.J.; Brayer, G.D.
Structure of the complex formed between the bacterial-produced inhibitor chymostatin and the serine enzyme Streptomyces griseus protease A
J. Mol. Biol.
139
45-51
1980
Streptomyces griseus
brenda
Mauer, C.A.
Active centers of Streptomyces griseus protease 1, Streptomyces griseus protease 3, and alpha-chymotrypsin: enzyme-substrate interactions
Biochemistry
17
375-380
1978
Streptomyces griseus
brenda
Blanchard, H.; James, M.N.G.
A crystallographic re-investigation into the structure of Streptomyces griseus proteinase A reveals an acyl-enzyme intermediate
J. Mol. Biol.
241
574-587
1994
Streptomyces griseus
brenda
Tomkinson, N.P.; Galpin, I.J.; Beynon, R.J.
Synthetic analogues of chymostatin. Inhibition of chymotrypsin and Streptomyces griseus proteinase A
Biochem. J.
286
475-480
1992
Streptomyces griseus
brenda
Brayer, G.D.; Delbaere, L.T.J.; James, M.N.G.
Molecular structure of crystalline Streptomyces griseus protease A at 2.8 A resolution. I. Crystallization, data collection and structural analysis
J. Mol. Biol.
124
243-259
1978
Streptomyces griseus
brenda
Brayer, G.D.; Delbaere, L.T.J.; James, M.N.G.
Molecular structure of crystalline Streptomyces griseus protease A at 2.8 A resolution. II. Molecular conformation, comparison with alpha-chymotrypsin and active-site geometry
J. Mol. Biol.
124
261-283
1978
Streptomyces griseus
brenda
Christensen, U.; Ishida, S.; Ishii, S.I.; Mitsui, Y.; Iitaka, Y.; McClarin, J.; Langridge, R.
Interactions of Streptomyces subtilisin inhibitor with Streptomyces griseus proteases A and B. Enzyme kinetic and computer simulation studies
J. Biochem.
98
1263-1274
1985
Streptomyces griseus
brenda
Qasim, M.A.; Wang, L.; Qasim, S.; Lu, S.; Lu, W.; Wynn, R.; Yi, Z.P.; Laskowski, M.
Additivity-based design of the strongest possible turkey ovomucoid third domain inhibitors for porcine pancreatic elastase (PPE) and Streptomyces griseus protease B (SGPB)
FEBS Lett.
587
3021-3026
2013
Streptomyces griseus
brenda