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Disease on EC 3.4.21.118 - kallikrein 8

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer.
Kallikrein-related peptidase 4 (KLK4) mRNA predicts short-term relapse in colorectal adenocarcinoma patients.
KLK15 is a prognostic marker for progression-free survival in patients with radical prostatectomy.
The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer.
Alzheimer Disease
Activation and enzymatic characterization of recombinant human kallikrein 8.
CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer's disease.
Genetic knockdown of Klk8 has sex-specific multi-targeted therapeutic effects on Alzheimer's pathology in mice.
HIGHER LEVELS OF KALLIKREIN-8 IN FEMALE BRAIN MAY INCREASE THE RISK FOR ALZHEIMER'S DISEASE.
Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model.
Visualizing protein-ligand binding with chemical energy-wise decomposition (CHEWD): application to ligand binding in the kallikrein-8 S1 Site.
Arthritis, Psoriatic
Serum kallikrein-8 correlates with skin activity, but not psoriatic arthritis, in patients with psoriatic disease.
Brain Injuries
Decreased levels of active uPA and KLK8 assessed by [(111) In]MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy.
Brain Ischemia
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke.
Breast Neoplasms
Clinical relevance of the deregulated kallikrein-related peptidase 8 mRNA expression in breast cancer: a novel independent indicator of disease-free survival.
Significant alterations in the expression pattern of kallikrein-related peptidase genes KLK4, KLK5 and KLK14 after treatment of breast cancer cells with the chemotherapeutic agents epirubicin, docetaxel and methotrexate.
Carcinogenesis
Kallikrein-related peptidase 13 (KLK13) gene expressional status contributes significantly in the prognosis of primary gastric carcinomas.
Carcinoma
Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.
Human kallikrein 8 protein is a favorable prognostic marker in ovarian cancer.
Human kallikrein 8, a novel biomarker for ovarian carcinoma.
Kallikrein-Related Peptidase mRNA Expression in Adenoid Cystic Carcinoma of Salivary Glands: A Polymerase Chain Reaction Study.
Kallikrein-related peptidase signaling in colon carcinoma cells: Targeting proteinase-activated receptors (PARs).
Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.
Carcinoma, Adenoid Cystic
Kallikrein-Related Peptidase mRNA Expression in Adenoid Cystic Carcinoma of Salivary Glands: A Polymerase Chain Reaction Study.
Carcinoma, Non-Small-Cell Lung
Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness.
Cardiomegaly
Erratum: Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy.
Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy.
Colonic Neoplasms
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.
Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells.
Colorectal Neoplasms
Clinical significance of kallikrein-related peptidase (KLK10) mRNA expression in colorectal cancer.
Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway.
Dementia, Vascular
The association of serum Kallikrein-8 with cognitive function in vascular dementia.
Demyelinating Diseases
Expression of neuropsin in oligodendrocytes after injury to the CNS.
Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis.
Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury.
Eczema
The hand eczema proteome: imbalance of epidermal barrier proteins.
Encephalomyelitis
Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis.
Epilepsy
Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.
Blockade of neuropsin, a serine protease, ameliorates kindling epilepsy.
Plasticity-related serine proteases in the brain (review).
Epilepsy, Temporal Lobe
Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.
Fasciculation
Extracellular serine protease neuropsin (KLK8) modulates neurite outgrowth and fasciculation of mouse hippocampal neurons in culture.
Hepatitis B, Chronic
Increase of Serum Kallikrein-8 Level After Long-term Telbivudine Treatment.
Herpes Zoster
Kindling induces neuropsin mRNA in the mouse brain.
Infections
Mouse mast cells express the tryptic protease neuropsin/Prss19.
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke.
Influenza, Human
Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin.
kallikrein 8 deficiency
Neuropsin-A possible modulator of synaptic plasticity.
Lung Neoplasms
Alternative Splicing Variant of Kallikrein-Related Peptidase 8 as an Independent Predictor of Unfavorable Prognosis in Lung Cancer.
Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness.
Myopia
Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.
Neoplasm Metastasis
Expression and clinical significance of KLK5-8 in endometrial cancer.
Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer.
The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer.
Neoplasms
A Four-kallikrein Panel Predicts High-grade Cancer on Biopsy: Independent Validation in a Community Cohort.
Aberrant expression of kallikrein-related peptidase 7 is correlated with human melanoma aggressiveness by stimulating cell migration and invasion.
Acteoside as a potential therapeutic option for primary hepatocellular carcinoma: a preclinical study.
Analysis of expression and prognosis of KLK7 in ovarian cancer.
Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer.
Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.
Expression and clinical significance of KLK5-8 in endometrial cancer.
Finding the Wolf in Sheep's Clothing: The 4Kscore Is a Novel Blood Test That Can Accurately Identify the Risk of Aggressive Prostate Cancer.
Genetic Association of the KLK4 Locus with Risk of Prostate Cancer.
Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer.
Human kallikrein 8 expression in salivary gland tumors.
Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness.
Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.
Kallikrein-related peptidase 4 (KLK4) mRNA predicts short-term relapse in colorectal adenocarcinoma patients.
Kallikrein-related peptidase expression in odontogenic cysts and tumors: An immunohistochemical comparative study.
Kallikrein-related peptidase genes as promising biomarkers for prognosis and monitoring of human malignancies.
Mass spectrometry based proteomics analyses in kallikrein-related peptidase research: implications for cancer research and therapy.
Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer.
Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer.
Silencing of kallikrein-related peptidase 6 attenuates the proliferation, migration, and invasion of gastric cancer cells through inhibition of epithelial-mesenchymal transition.
The kallikrein-related peptidase family: Dysregulation and functions during cancer progression.
The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer.
The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition.
The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer.
Upregulation of KLK8 Predicts Poor Prognosis in Pancreatic Cancer.
Odontogenic Cysts
Kallikrein-related peptidase expression in odontogenic cysts and tumors: An immunohistochemical comparative study.
Ovarian Neoplasms
Activation and enzymatic characterization of recombinant human kallikrein 8.
Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome.
Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins.
Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients.
Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients' survival.
Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer.
Clinical value of protein expression of kallikrein-related peptidase 7 (KLK7) in ovarian cancer.
Expression and prognostic significance of kallikrein-related peptidase 8 protein levels in advanced ovarian cancer by using automated quantitative analysis.
Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer.
Human kallikrein 8 protein is a favorable prognostic marker in ovarian cancer.
Proteomic and other analyses to determine the functional consequences of deregulated kallikrein-related peptidase (KLK) expression in prostate and ovarian cancer.
Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients.
The prognostic and diagnostic potential of kallikrein-related peptidases in ovarian cancer.
Visualizing protein-ligand binding with chemical energy-wise decomposition (CHEWD): application to ligand binding in the kallikrein-8 S1 Site.
Parkinson Disease
Oral Administration of Probiotic Bifidobacterium breve Improves Facilitation of Hippocampal Memory Extinction via Restoration of Aberrant Higher Induction of Neuropsin in an MPTP-Induced Mouse Model of Parkinson's Disease.
Prostatic Diseases
Enzymatically active prostate-specific antigen promotes growth of human prostate cancers.
Prostatic Neoplasms
Assessment of 54 biomarkers for biopsy-detectable prostate cancer.
Can one blood draw replace transrectal ultrasonography-estimated prostate volume to predict prostate cancer risk?
Crystal structure of human prostate-specific antigen in a sandwich antibody complex.
Genetic Association of the KLK4 Locus with Risk of Prostate Cancer.
In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.
KLK15 is a prognostic marker for progression-free survival in patients with radical prostatectomy.
Prospective validation of microseminoprotein-? added to the 4Kscore in predicting high-grade prostate cancer in an international multicentre cohort.
Very low PSA concentrations and deletions of the KLK3 gene.
Psoriasis
Skin Surface Protein Detection by Transdermal Analysis Patches in Pediatric Psoriasis.
Rosacea
Epidermal proteases in the pathogenesis of rosacea.
Skin Diseases
Kallikrein-Related Peptidase 8-Dependent Skin Wound Healing Is Associated with Upregulation of Kallikrein-Related Peptidase 6 and PAR2.
Spinal Cord Injuries
Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury.
Status Epilepticus
Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.
Stomach Neoplasms
Silencing of kallikrein-related peptidase 6 attenuates the proliferation, migration, and invasion of gastric cancer cells through inhibition of epithelial-mesenchymal transition.
Uterine Cervical Neoplasms
The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer.