Disease on EC 3.4.21.118 - kallikrein 8
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Adenocarcinoma
Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer.
Adenocarcinoma
Kallikrein-related peptidase 4 (KLK4) mRNA predicts short-term relapse in colorectal adenocarcinoma patients.
Adenocarcinoma
KLK15 is a prognostic marker for progression-free survival in patients with radical prostatectomy.
Adenocarcinoma
The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer.
Alzheimer Disease
Activation and enzymatic characterization of recombinant human kallikrein 8.
Alzheimer Disease
CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer's disease.
Alzheimer Disease
Genetic knockdown of Klk8 has sex-specific multi-targeted therapeutic effects on Alzheimer's pathology in mice.
Alzheimer Disease
HIGHER LEVELS OF KALLIKREIN-8 IN FEMALE BRAIN MAY INCREASE THE RISK FOR ALZHEIMER'S DISEASE.
Alzheimer Disease
Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model.
Alzheimer Disease
Visualizing protein-ligand binding with chemical energy-wise decomposition (CHEWD): application to ligand binding in the kallikrein-8 S1 Site.
Arthritis, Psoriatic
Serum kallikrein-8 correlates with skin activity, but not psoriatic arthritis, in patients with psoriatic disease.
Brain Injuries
Decreased levels of active uPA and KLK8 assessed by [(111) In]MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy.
Brain Ischemia
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke.
Breast Neoplasms
Clinical relevance of the deregulated kallikrein-related peptidase 8 mRNA expression in breast cancer: a novel independent indicator of disease-free survival.
Breast Neoplasms
Significant alterations in the expression pattern of kallikrein-related peptidase genes KLK4, KLK5 and KLK14 after treatment of breast cancer cells with the chemotherapeutic agents epirubicin, docetaxel and methotrexate.
Carcinogenesis
Kallikrein-related peptidase 13 (KLK13) gene expressional status contributes significantly in the prognosis of primary gastric carcinomas.
Carcinoma
Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.
Carcinoma
Kallikrein-Related Peptidase mRNA Expression in Adenoid Cystic Carcinoma of Salivary Glands: A Polymerase Chain Reaction Study.
Carcinoma
Kallikrein-related peptidase signaling in colon carcinoma cells: Targeting proteinase-activated receptors (PARs).
Carcinoma
Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.
Carcinoma, Adenoid Cystic
Kallikrein-Related Peptidase mRNA Expression in Adenoid Cystic Carcinoma of Salivary Glands: A Polymerase Chain Reaction Study.
Carcinoma, Non-Small-Cell Lung
Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness.
Cardiomegaly
Erratum: Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy.
Cardiomegaly
Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy.
Colonic Neoplasms
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.
Colonic Neoplasms
Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells.
Colorectal Neoplasms
Clinical significance of kallikrein-related peptidase (KLK10) mRNA expression in colorectal cancer.
Colorectal Neoplasms
Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway.
Dementia, Vascular
The association of serum Kallikrein-8 with cognitive function in vascular dementia.
Demyelinating Diseases
Expression of neuropsin in oligodendrocytes after injury to the CNS.
Demyelinating Diseases
Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis.
Demyelinating Diseases
Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury.
Encephalomyelitis
Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis.
Epilepsy
Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.
Epilepsy, Temporal Lobe
Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.
Fasciculation
Extracellular serine protease neuropsin (KLK8) modulates neurite outgrowth and fasciculation of mouse hippocampal neurons in culture.
Hepatitis B, Chronic
Increase of Serum Kallikrein-8 Level After Long-term Telbivudine Treatment.
Infections
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke.
Influenza, Human
Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin.
Lung Neoplasms
Alternative Splicing Variant of Kallikrein-Related Peptidase 8 as an Independent Predictor of Unfavorable Prognosis in Lung Cancer.
Lung Neoplasms
Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness.
Neoplasm Metastasis
Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer.
Neoplasm Metastasis
The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer.
Neoplasms
A Four-kallikrein Panel Predicts High-grade Cancer on Biopsy: Independent Validation in a Community Cohort.
Neoplasms
Aberrant expression of kallikrein-related peptidase 7 is correlated with human melanoma aggressiveness by stimulating cell migration and invasion.
Neoplasms
Acteoside as a potential therapeutic option for primary hepatocellular carcinoma: a preclinical study.
Neoplasms
Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer.
Neoplasms
Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.
Neoplasms
Finding the Wolf in Sheep's Clothing: The 4Kscore Is a Novel Blood Test That Can Accurately Identify the Risk of Aggressive Prostate Cancer.
Neoplasms
Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer.
Neoplasms
Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness.
Neoplasms
Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?
Neoplasms
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.
Neoplasms
Kallikrein-related peptidase 4 (KLK4) mRNA predicts short-term relapse in colorectal adenocarcinoma patients.
Neoplasms
Kallikrein-related peptidase expression in odontogenic cysts and tumors: An immunohistochemical comparative study.
Neoplasms
Kallikrein-related peptidase genes as promising biomarkers for prognosis and monitoring of human malignancies.
Neoplasms
Mass spectrometry based proteomics analyses in kallikrein-related peptidase research: implications for cancer research and therapy.
Neoplasms
Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer.
Neoplasms
Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer.
Neoplasms
Silencing of kallikrein-related peptidase 6 attenuates the proliferation, migration, and invasion of gastric cancer cells through inhibition of epithelial-mesenchymal transition.
Neoplasms
The kallikrein-related peptidase family: Dysregulation and functions during cancer progression.
Neoplasms
The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer.
Neoplasms
The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition.
Neoplasms
The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer.
Odontogenic Cysts
Kallikrein-related peptidase expression in odontogenic cysts and tumors: An immunohistochemical comparative study.
Ovarian Neoplasms
Activation and enzymatic characterization of recombinant human kallikrein 8.
Ovarian Neoplasms
Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome.
Ovarian Neoplasms
Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins.
Ovarian Neoplasms
Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients.
Ovarian Neoplasms
Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients' survival.
Ovarian Neoplasms
Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer.
Ovarian Neoplasms
Clinical value of protein expression of kallikrein-related peptidase 7 (KLK7) in ovarian cancer.
Ovarian Neoplasms
Expression and prognostic significance of kallikrein-related peptidase 8 protein levels in advanced ovarian cancer by using automated quantitative analysis.
Ovarian Neoplasms
Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer.
Ovarian Neoplasms
Human kallikrein 8 protein is a favorable prognostic marker in ovarian cancer.
Ovarian Neoplasms
Proteomic and other analyses to determine the functional consequences of deregulated kallikrein-related peptidase (KLK) expression in prostate and ovarian cancer.
Ovarian Neoplasms
Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients.
Ovarian Neoplasms
The prognostic and diagnostic potential of kallikrein-related peptidases in ovarian cancer.
Ovarian Neoplasms
Visualizing protein-ligand binding with chemical energy-wise decomposition (CHEWD): application to ligand binding in the kallikrein-8 S1 Site.
Parkinson Disease
Oral Administration of Probiotic Bifidobacterium breve Improves Facilitation of Hippocampal Memory Extinction via Restoration of Aberrant Higher Induction of Neuropsin in an MPTP-Induced Mouse Model of Parkinson's Disease.
Prostatic Diseases
Enzymatically active prostate-specific antigen promotes growth of human prostate cancers.
Prostatic Neoplasms
Can one blood draw replace transrectal ultrasonography-estimated prostate volume to predict prostate cancer risk?
Prostatic Neoplasms
Crystal structure of human prostate-specific antigen in a sandwich antibody complex.
Prostatic Neoplasms
In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.
Prostatic Neoplasms
KLK15 is a prognostic marker for progression-free survival in patients with radical prostatectomy.
Prostatic Neoplasms
Prospective validation of microseminoprotein-? added to the 4Kscore in predicting high-grade prostate cancer in an international multicentre cohort.
Psoriasis
Skin Surface Protein Detection by Transdermal Analysis Patches in Pediatric Psoriasis.
Skin Diseases
Kallikrein-Related Peptidase 8-Dependent Skin Wound Healing Is Associated with Upregulation of Kallikrein-Related Peptidase 6 and PAR2.
Spinal Cord Injuries
Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury.
Status Epilepticus
Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.
Stomach Neoplasms
Silencing of kallikrein-related peptidase 6 attenuates the proliferation, migration, and invasion of gastric cancer cells through inhibition of epithelial-mesenchymal transition.
Uterine Cervical Neoplasms
The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer.
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