Information on EC 3.4.19.14 - leukotriene-C4 hydrolase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC3.4.19.14
Word Map on EC 3.4.19.14
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)


The taxonomic range for the selected organisms is: Homo sapiens

The enzyme appears in selected viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.19.14
-
RECOMMENDED NAME
GeneOntology No.
leukotriene-C4 hydrolase
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
arachidonic acid metabolism
-
-
Arachidonic acid metabolism
-
-
Metabolic pathways
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glutathione sulfonic acid + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
show the reaction diagram
-
-
-
-
?
leukotriene C4 + H2O
leukotriene D4 + L-glutamate
show the reaction diagram
-
-
-
-
?
oxidized glutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
show the reaction diagram
-
-
-
-
?
reduced glutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
show the reaction diagram
-
-
-
-
?
S-(4-nitro-benzyl)glutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
show the reaction diagram
-
-
-
-
?
S-methylglutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
no activity with gamma-glutamyl leucine
-
-
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
serine-borate
-
8fold more potent in inhibiting GGT1 than in inhibiting GGT5
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0751
glutathione sulfonic acid
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0102
leukotriene C4
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.426
oxidized glutathione
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.105
reduced glutathione
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0148
S-(4-nitro-benzyl)glutathione
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0182
S-Methylglutathione
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Pichia pastoris
-