Information on EC 3.4.19.13 - glutathione hydrolase and Organism(s) Homo sapiens

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria


The taxonomic range for the selected organisms is: Homo sapiens

EC NUMBER
COMMENTARY hide
3.4.19.13
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RECOMMENDED NAME
GeneOntology No.
glutathione hydrolase
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
4-hydroxy-2-nonenal detoxification
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felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis
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glutathione degradation (DUG pathway - yeast)
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glutathione-mediated detoxification I
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glutathione-mediated detoxification II
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indole glucosinolate activation (intact plant cell)
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Glutathione metabolism
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Metabolic pathways
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
7-(gamma-L-glutamylamino)-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-glutamate
show the reaction diagram
-
-
-
-
?
gamma-glutamyl L-leucine + H2O
L-leucine + L-glutamate
show the reaction diagram
-
-
-
?
glutathione sulfonic acid + H2O
? + L-glutamate
show the reaction diagram
-
-
-
?
leukotriene C4 + H2O
?
show the reaction diagram
-
-
-
?
oxidized glutathione + H2O
? + L-glutamate
show the reaction diagram
-
-
-
?
reduced glutathione + H2O
L-cysteinylglycine + L-glutamate
show the reaction diagram
-
-
-
?
S-(4-nitro-benzyl)glutathione + H2O
S-(4-nitro-benzyl)-L-cysteinylglycine + L-glutamate
show the reaction diagram
-
-
-
?
S-(5-hydroxy-2-pentyltetrahydrofuran-3-yl)glutathione + H2O
S-(5-hydroxy-2-pentyltetrahydrofuran-3-yl)-L-cysteinylglycine + L-glutamate
show the reaction diagram
-
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the GGT-dependent metabolism of S-(5-hydroxy-2-pentyltetrahydrofuran-3-yl)glutathione in the V79 GGT cell line is associated with a considerable increase of cytotoxicity. The cytotoxic effect is dose- and time-dependent, with 100% cellular death at 200 mM S-(5-hydroxy-2-pentyltetrahydrofuran-3-yl)glutathione after 24 h incubation in V79 GGT cells
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?
S-methylglutathione + H2O
S-methyl-L-cysteinylglycine + L-glutamate
show the reaction diagram
-
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?
additional information
?
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2RS)-2-amino-4-((S)-1-[N-(carboxymethyl)carbamoyl]propyl(phenyl)-phosphono)butanoic acid
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potent and irreversible inhibitor of human enzyme, second-order rate constant value 145 per M and s, and good mimic of the putative transition state
acivicin
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serine borate
competitive, 8fold less effective as an inhibitor of isoform GGT5 than of GGT1; competitive, 8fold less effective as an inhibitor of isoform GGT5 than of GGT1
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0334
gamma-glutamyl L-leucine
pH 7.4, 37°C
0.0346 - 0.0751
glutathione sulfonic acid
0.0102 - 0.0108
leukotriene C4
0.0088 - 0.0426
oxidized glutathione
0.0105 - 0.0106
reduced glutathione
0.0131 - 0.0148
S-(4-nitro-benzyl)glutathione
0.0182 - 0.099
S-Methylglutathione
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.2
serine borate
pH 7.4, 37°C
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
PDB
SCOP
CATH
UNIPROT
ORGANISM
Homo sapiens;
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in NIH/3T3 cell
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expression in V79 fibroblast cell
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine