Reference on EC 3.4.14.4 - dipeptidyl-peptidase III
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
McDonald, J.K.; Schwabe, C.
Dipeptidyl aminopeptidase III (EC 3.4.14.-)
Proteinases in Mammalian Cells and Tissues (Barrett, A. J. , ed. )
361-364
1977
Bos taurus, Rattus norvegicus
-
Alba, F.; Arenas, J.C.; Lopez, M.A.
Properties of rat brain dipeptidyl aminopeptidases in the presence of detergents
Peptides
16
325-329
1995
Rattus norvegicus
Shimamori, Y.; Watanabe, Y.; Fujimoto, Y.
Human placental dipeptidyl aminopeptidase III: Hydrolysis of enkephalins and its stimulation by cobaltus ions
Biochem. Med. Metab. Biol.
40
305-310
1988
Homo sapiens
Vanha-Perttula, T.
Dipeptidyl peptidase III and alanyl aminopeptidase in the human seminal plasma: Origin and biochemical properties
Clin. Chim. Acta
177
179-196
1988
Homo sapiens
Abramic, M.; Zubanovic, M.; Vitale, L.
Dipeptidyl peptidase III from human erythrocytes
Biol. Chem. Hoppe-Seyler
369
29-38
1988
Homo sapiens
Inaoka, Y.; Tamaoki, H.
Purification and characterization of enkephalinase B from rat brain membrane
Biochim. Biophys. Acta
925
27-35
1987
Rattus norvegicus
Chan., S.A.T.; Jones, T.H.D.; Sweeney, J.P.; Toursarkissian, K.
Partial purification and characterization of dipeptidyl-aminopeptidase III from Dictostelium discoideum
Exp. Mycol.
11
27-35
1987
Dictyostelium discoideum
-
Shimamori, Y.; Watanabe, Y.; Fujimoto, Y.
Purification and characterization of dipeptidyl aminopeptidase III from human placenta
Chem. Pharm. Bull.
34
3333-3340
1986
Homo sapiens
Nishikiori, T.; Kawahara, F.; Naganawa, H.; Muraoka, Y.; Aoyagi, T.; Umezawa, H.
Production of acetyl-L-leucyl-L-argininal, inhibitor of dipeptidyl aminopeptidase III by bacteria
J. Antibiot.
37
680-681
1984
Rattus norvegicus
Lee, C.M.; Snyder, S.H.
Dipeptidyl-aminopeptidase III of rat brain. Selective affinity for enkephalin and angiotensin
J. Biol. Chem.
257
12043-12050
1982
Rattus norvegicus
Jones, T.H.D.; Kapralou, A.
A rapid assay for dipeptidyl aminopeptidase III in human erythrocytes
Anal. Biochem.
119
418-423
1982
Homo sapiens
Swanson, A.A; Albers-Jackson, B.; McDonald, J.K.
Mammalian lens dipeptidyl aminopeptidase III
Biochem. Biophys. Res. Commun.
84
1151-1159
1978
Bos taurus
Fukasawa, K.; Fukasawa, K.M.; Kanai, M.; Fujii, S.; Hirose, J.; Harada, M.
Dipeptidyl peptidase III is a zinc metallo-exopeptidase
Biochem. J.
329
275-282
1998
Homo sapiens
Fukasawa, K.; Fukasawa, K.M.; Iwamoto, G.; Hirose, J.; Harada, M.
The HELLGH motif of rat liver dipeptidyl peptidase III is involved in zinc coordination and the catalytic activity of the enzyme
Biochemistry
38
8299-8303
1999
Rattus norvegicus
Huang, J.; Kim, J.; Ramamurthy, P.; Jones, T.H.D.
The purification, specificity, and role of dipeptidyl peptidase III in Dictostelium discoideum
Exp. Mycol.
16
102-109
1992
Dictyostelium discoideum
-
Simaga, S.; Babic, D.; Osmak, M.; Ilic-Forko, J.; Vitale, L.; Milicic, D.; Abramic, M.
Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue
Eur. J. Cancer
34
399-405
1998
Homo sapiens
Mazzocco, C.; Fukasawa, K.M.; Auguste, P.; Puiroux J.
Characterization of a functionally expressed dipeptidyl aminopeptidase III from Drosophila melanogaster
Eur. J. Biochem.
270
3074-3082
2003
Drosophila melanogaster
Smyth, M.; O'Cuinn, G.
Dipeptidyl aminopeptidase activities of guinea-pig brain
Int. J. Biochem.
26
913-921
1994
Cavia porcellus
Lynn, K.R.
The isolation and some properties of dipeptidyl peptidases II and III from porcine spleen
Int. J. Biochem.
23
47-50
1991
Sus scrofa
Hola-Jamriska, L.; Dalton, J.P.; Aaskow, J.; Brindley, P.J.
Dipeptidyl peptidase I and III activities of adult schistosomes
Parasitology
118
275-282
1999
Schistosoma sp.
Sentrandreu, M.A.; Toldra, F.
Biochemical properties of dipeptidyl peptidase III purified from porcine skeletal muscle.
J. Agric. Food Chem.
46
3977-3984
1998
Sus scrofa
Smyth, M.; O'Cuinn, G.
Dipeptidyl aminopeptidase III of guinea-pig brain: Specificity for short oligopeptide sequences
J. Neurochem.
63
1439-1445
1994
Cavia porcellus
Watanabe, Y.; Kumagai, Y.; Fujimoto, Y.
Presence of a dipeptidyl aminopeptidase III in Saccharomyces cerevisiae
Chem. Pharm. Bull.
38
246-248
1990
Saccharomyces cerevisiae
Li, Y.H.; Maeda, T.; Yamane, T.; Ohkubo, I.
Alteration of rat dipeptidyl peptidase III by site-directed mutagenesis: Cysteine176 is a regulatory residue for the enzyme activity
Biochem. Biophys. Res. Commun.
276
553-558
2000
Rattus norvegicus
Hirose, J.; Iwamoto, H.; Nagao, I.; Enmyo, K.; Sugao, H.; Kanemitu, N.; Ikeda, K.; Takeda, M.; Inoue, M.; Ikeda, T.; Matsuura, F.; Fukasawa, K.M.; Fukasawa, K.
Characterization of the metal-substituted dipeptidyl peptidase III (rat liver)
Biochemistry
40
11860-11865
2001
Rattus norvegicus
Abramic, M.; Schleuder, D.; Dolovcak, L.; Schroder, W.; Strupat, K.; Sagi, D.; Peter-Katalini, J.; Vitale, L.
Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differences
Biol. Chem.
381
1233-1243
2000
Homo sapiens, Rattus norvegicus
Yamamoto, Y.; Hashimoto, J.i.; Shimamura, M.; Yamaguchi, T.; Hazato, T.
Characterization of tynorphin, a potent endogenous inhibitor of dipeptidyl peptidaseIII
Peptides
21
503-508
2000
Platyrrhini
Chiba, T.; Li, Y.H.; Yamane, T.; Ogikubo, O.; Fukuoka, M.; Arai, R.; Takahashi, S.; Ohtsuka, T.; Ohkubo, I.; Matsui, N.
Inhibition of recombinant dipeptidyl peptidase III by synthetic hemorphin-like peptides
Peptides
24
773-778
2003
Platyrrhini
Mazzocco, C.; Gillibert-Duplantier, J.; Neaud, V.; Fukasawa, K.M.; Claverol, S.; Bonneu, M.; Puiroux, J.
Identification and characterization of two dipeptidyl-peptidase III isoforms in Drosophila melanogaster
FEBS J.
273
1056-1064
2006
Drosophila melanogaster (Q9VHR8), Drosophila melanogaster
Agic, D.; Hranjec, M.; Jajcanin, N.; Starcevic, K.; Karminski-Zamola, G.; Abramic, M.
Novel amidino-substituted benzimidazoles: synthesis of compounds and inhibition of dipeptidyl peptidase III
Bioorg. Chem.
35
153-169
2007
Homo sapiens
Wattiaux, R.; Wattiaux-de Coninck, S.; Thirion, J.; Gasingirwa, M.C.; Jadot, M.
Lysosomes and Fas-mediated liver cell death
Biochem. J.
403
89-95
2007
Homo sapiens
Barsun, M.; Jajcanin, N.; Vukeli?, B.; Spoljari?, J.; Abrami?, M.
Human dipeptidyl peptidase III acts as a post-proline-cleaving enzyme on endomorphins
Biol. Chem.
388
343-348
2007
Homo sapiens
Salopek-Sondi, B.; Vukelic, B.; Spoljaric, J.; Simaga, S.; Vujaklija, D.; Makarevic, J.; Jajcanin, N.; Abramic, M.
Functional tyrosine residue in the active center of human dipeptidyl peptidase III
Biol. Chem.
389
163-167
2008
Homo sapiens (Q9NY33), Homo sapiens
Dhanda, S.; Singh, J.; Singh, H.
Hydrolysis of various bioactive peptides by goat brain dipeptidylpeptidase-III homologue
Cell Biochem. Funct.
26
339-345
2007
Capra hircus
Simaga, S.; Abramic, M.; Osmak, M.; Babic, D.; Ilic-Forko, J.
Total tissue lactate dehydrogenase activity in endometrial carcinoma
Int. J. Gynecol. Cancer
18
1272-1278
2008
Homo sapiens
Dhanda, S.; Singh, H.; Singh, J.; Singh, T.P.
Isolation, purification and characterization of a DPP-III homologue from goat brain
Protein Expr. Purif.
52
297-305
2007
Capra hircus
Tye, C.E.; Lorenz, R.L.; Bartlett, J.D.
Lysosomal protease expression in mature enamel
Cells Tissues Organs
189
111-114
2009
Mus musculus
Baral, P.K.; Jajcanin-Jozic, N.; Deller, S.; Macheroux, P.; Abramic, M.; Gruber, K.
The first structure of dipeptidyl-peptidase III provides insight into the catalytic mechanism and mode of substrate binding
J. Biol. Chem.
283
22316-22324
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Dhanda, S.; Singh, H.; Singh, J.; Singh, T.P.
Functional characterization and specific effects of various peptides on enzymatic activity of a DPP-III homologue from goat brain
J. Enzyme Inhib. Med. Chem.
23
174-181
2008
Capra hircus
Cicin-Sain, L.; Simaga, S.; Froebe, A.; Abramic, M.
Central aminopeptidase and serotonin system activities: possible relationship
Neuropeptides
42
435-440
2008
Rattus norvegicus
Jajcanin-Jozic, N.; Deller, S.; Pavkov, T.; Macheroux, P.; Abramic, M.
Identification of the reactive cysteine residues in yeast dipeptidyl peptidase III
Biochimie
92
89-96
2010
Saccharomyces cerevisiae (Q08225), Saccharomyces cerevisiae
Spoljaric, J.; Salopek-Sondi, B.; Makarevic, J.; Vukelic, B.; Agic, D.; Simaga, S.; Jajcanin-Jozic, N.; Abramic, M.
Absolutely conserved tryptophan in M49 family of peptidases contributes to catalysis and binding of competitive inhibitors
Bioorg. Chem.
37
70-76
2009
Homo sapiens (Q9NY33), Homo sapiens
Casewell, N.R.; Harrison, R.A.; Wuester, W.; Wagstaff, S.C.
Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts
BMC Genomics
10
564
2009
Echis pyramidum leakeyi, Echis carinatus sochureki, Echis coloratus
Shukla, A.A.; Jain, M.; Chauhan, S.S.
Ets-1/Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells
FEBS J.
277
1861-1875
2010
Homo sapiens (Q9NY33), Homo sapiens
Isaac, R.; Bland, N.; Shirras, A.
Neuropeptidases and the metabolic inactivation of insect neuropeptides
Gen. Comp. Endocrinol.
162
8-17
2009
Blaberus craniifer, Drosophila melanogaster (Q9VHR8)
Flores, M.; Aristoy, M.C.; Antequera, T.; Barat, J.M.; Toldra, F.
Effect of prefreezing hams on endogenous enzyme activity during the processing of Iberian dry-cured hams
Meat Sci.
82
241-246
2009
Sus scrofa domesticus
Hirose, J.; Hata, T.; Kawaoka, C.; Ikeura, T.; Kitahara, S.; Horii, K.; Tomida, H.; Iwamoto, H.; Ono, Y.; Fukasawa, K.M.
Flexibility of the coordination geometry around the cupric ions in Cu(II)-rat dipeptidyl peptidase III is important for the expression of enzyme activity
Arch. Biochem. Biophys.
525
71-81
2012
Rattus norvegicus
Abramic, M.; Karacic, Z.; Semanjski, M.; Vukelic, B.; Jajcanin-Jozic, N.
Aspartate 496 from the subsite S2 drives specificity of human dipeptidyl peptidase III
Biol. Chem.
396
359-366
2015
Homo sapiens
Tomic, A.; Tomic, S.
Hunting the human DPP III active conformation: combined thermodynamic and QM/MM calculations
Dalton Trans.
43
15503-15514
2014
Homo sapiens (Q9NY33), Homo sapiens
Jajcanin-Jozic, N.; Tomic, S.; Abramic, M.
Importance of the three basic residues in the vicinity of the zinc-binding motifs for the activity of the yeast dipeptidyl peptidase III
J. Biochem.
155
43-50
2014
Saccharomyces cerevisiae (Q08225), Saccharomyces cerevisiae
Tomic, A.; Gonzalez, M.; Tomic, S.
The large scale conformational change of the human DPP III-substrate prefers the "closed" form
J. Chem. Inf. Model.
52
1583-1594
2012
Homo sapiens (Q9NY33), Homo sapiens
Bezerra, G.A.; Dobrovetsky, E.; Viertlmayr, R.; Dong, A.; Binter, A.; Abramic, M.; Macheroux, P.; Dhe-Paganon, S.; Gruber, K.
Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III
Proc. Natl. Acad. Sci. USA
109
6525-6530
2012
Homo sapiens (Q9NY33), Homo sapiens
Jodha, D.; Attri, P.; Khaket, T.; Singh, J.
Isolation, purification and biochemical characterization of dipeptidyl peptidase-III from germinated Vigna radiata seeds
Process Biochem.
48
730-737
2013
Vigna radiata
-
Rastija, V.; Agic, D.; Tomic, S.; Nikolic, S.; Hranjec, M.; Grace, K.Z.; Abramic, M.
Synthesis, QSAR, and molecular dynamics simulation of amidino-substituted benzimidazoles as dipeptidyl peptidase III inhibitors
Acta Chim. Slov.
62
867-878
2015
Homo sapiens (Q9NY33), Homo sapiens
Karacic, Z.; Vukelic, B.; Ho, G.; Jozic, I.; Sucec, I.; Salopek-Sondi, B.; Kozlovic, M.; Brenner, S.; Ludwig-Mueller, J.; Abramic, M.
A novel plant enzyme with dual activity An atypical Nudix hydrolase and a dipeptidyl peptidase III
Biol. Chem.
398
101-112
2017
Physcomitrium patens (A9TLP4), Physcomitrium patens, Arabidopsis thaliana (Q8L831), Arabidopsis thaliana
Agic, D.; Brkic, H.; Tomic, S.; Karacic, Z.; Spoljarevic, M.; Lisjak, M.; Beslo, D.; Abramic, M.
Validation of flavonoids as potential dipeptidyl peptidase III inhibitors Experimental and computational approach
Chem. Biol. Drug Des.
89
619-627
2017
Homo sapiens (Q9NY33), Homo sapiens
Agic, D.; Brkic, H.; Kazazic, S.; Tomic, A.; Abramic, M.
Aprotinin interacts with substrate-binding site of human dipeptidyl peptidase III
J. Biomol. Struct. Dyn.
37
3596-3606
2018
Homo sapiens (Q9NY33), Homo sapiens
Cvitesic, A.; Sabljic, I.; Makarevic, J.; Abramic, M.
Novel dipeptidyl hydroxamic acids that inhibit human and bacterial dipeptidyl peptidase III
J. Enzyme Inhib. Med. Chem.
31
40-45
2016
Bacteroides thetaiotaomicron (Q8A6N1), Bacteroides thetaiotaomicron, Homo sapiens (Q9NY33), Homo sapiens, Bacteroides thetaiotaomicron DSM 2079 (Q8A6N1)
Prajapati, S.C.; Chauhan, S.S.
Human dipeptidyl peptidase III mRNA variant I and II are expressed concurrently in multiple tumor derived cell lines and translated at comparable efficiency in vitro
Mol. Biol. Rep.
43
457-462
2016
Homo sapiens
Attri, P.; Jodha, D.; Singh, J.; Dhanda, S.
Purification, kinetic and functional characterization of membrane bound dipeptidyl peptidase-III from NCDC 252 a probiotic lactic acid bacteria
Mol. Biol. Rep.
45
973-986
2018
Pediococcus acidilactici
Tomin, M.; Tomic, S.
Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study
Mol. Biosyst.
13
2407-2417
2017
Bacteroides thetaiotaomicron
Sabljic, I.; Mestrovic, N.; Vukelic, B.; Macheroux, P.; Gruber, K.; Luic, M.; Abramic, M.
Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron
PLoS ONE
12
e0187295
2017
Bacteroides thetaiotaomicron (Q8A6N1), Bacteroides thetaiotaomicron, Bacteroides thetaiotaomicron DSM 2079 (Q8A6N1)
Hromic-Jahjefendic, A.; Jajcanin Jozic, N.; Kazazic, S.; Grabar Branilovic, M.; Karacic, Z.; Schrittwieser, J.H.; Das, K.M.P.; Tomin, M.; Oberer, M.; Gruber, K.; Abramic, M.; Tomic, S.
A novel Porphyromonas gingivalis enzyme An atypical dipeptidyl peptidase III with an ARM repeat domain
PLoS ONE
12
e0188915
2017
Porphyromonas gingivalis (Q7MX92), Porphyromonas gingivalis
Sabljic, I.; Tomin, M.; Matovina, M.; Sucec, I.; Tomacic Paic, A.; Tomic, A.; Abramic, M.; Tomic, S.
The first dipeptidyl peptidase III from a thermophile Structural basis for thermal stability and reduced activity
PLoS ONE
13
e0192488
2018
Caldithrix abyssi (H1XW48), Caldithrix abyssi, Caldithrix abyssi DSM 13497 (H1XW48)
Matic, J.; Supljika, F.; Tir, N.; Piotrowski, P.; Schmuck, C.; Abramic, M.; Piantanida, I.; Tomic, S.
Guanidiniocarbonyl-pyrrole-aryl conjugates as inhibitors of human dipeptidyl peptidase III Combined experimental and computational study
RSC Adv.
6
83044-83052
2016
Homo sapiens (Q9NY33)
-
Matovina, M.; Agic, D.; Abramic, M.; Matic, S.; Karacic, Z.; Tomic, S.
New findings about human dipeptidyl peptidase III based on mutations found in cancer
RSC Adv.
7
36326-36334
2017
Homo sapiens (Q9NY33)
-
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