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Disease on EC 3.4.11.1 - leucyl aminopeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
ERAP, KIR and HLA-C gene interaction in susceptibility to recurrent spontaneous abortion in the Polish population.
Abortion, Threatened
[Serum leucine aminopeptidase activity in threatened abortion, prolonged pregnancy and pregnancy toxemias]
Adenocarcinoma
Biochemical methods for predicting metastatic ability of prostatic cancer utilizing the dunning R-3327 rat prostatic adenocarcinoma system as a model.
Cytoenzymology of benign and malignant tumours of the corpus uteri. III. Alkaline phosphatase, non-specific esterase and leucine aminopeptidase.
Adenoma, Bile Duct
[Usefulness of carbohydrate antigen 19-9 (CA19-9) for the diagnosis of cholangioma. As a role of screening patients with the elevation of serum alkaline phosphatase, leucine aminopeptidase and/or gamma-glutamyl transpeptidase]
Anemia
Subacute thyroiditis associated with systemic multi-organ disorders.
Appendicitis
Experimental model of acute appendicitis in the rabbit with determination of leucine amino peptidase (LAP) and acid phosphatase (acid-P) activities in portal blood samples.
Arthritis
[Determination of leucine aminopeptidase in the serum and synovial fluid of patients with progressive chronic polyarthritis]
Arthritis, Psoriatic
ERAP1 and ERAP2 Gene Variations Influence the Risk of Psoriatic Arthritis in Romanian Population.
Arthritis, Rheumatoid
Alkaline phosphatase isoenzyme activities in rheumatoid arthritis: hepatobiliary enzyme dissociation and relation to disease activity.
Evaluation of the renal injury from gold salts and nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis.
Expression of ERAP2 and LST1 is increased before start of therapy in rheumatoid arthritis patients with good clinical response to glucocorticoids.
Asthma
Leucine aminopeptidase activity in the serum and urine in allergic bronchial asthma.
[Changes in the activity of serum leucine aminopeptidase in bronchial asthma]
[Leucine aminopeptidase activity (LAP) in the serum and urine of patients with allergic bronchial asthma]
Autoimmune Diseases
Autoimmune risk variants in ERAP2 are associated with gene-expression levels in thymus.
ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population.
Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations.
Peptide Trimming for MHC Class I Presentation by Endoplasmic Reticulum Aminopeptidases.
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
Azotemia
Lactic dehydrogenase, leucine aminopeptidase, alpha globulin, and azotemia in circulatory stress.
Bacterial Infections
A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.
Bile Duct Neoplasms
[Diagnostic significance of serum leucine aminopeptidase, alkaline phosphatase and lactic dehydrogenase isozymes in liver and bile duct cancer]
Biliary Atresia
Serum leucine aminopeptidase activity in normal infants, in biliary atresia, and in other diseases.
Biliary Tract Diseases
[Comparative studies of the activity of leucine aminopeptidase and glycyl aminopeptidase in liver and biliary tract diseases]
[Comparative study of leucyl aminopeptidase and glycyl aminopeptidase activity in liver and biliary tract diseases. I. Behavior of both enzymes in serum and liver tissue]
Birdshot Chorioretinopathy
A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy.
The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
Blister
Hepatic toxicity in the rhesus monkey treated with chenodeoxycholic acid for 6 months: biochemical and ultrastructural studies.
[Leucine aminopeptidase activity in blood serum & blister content. II. Studies in patients with psoriasis, neurodermatitis diffusa, dermatitis, eczema & other dermatoses.]
[Leucine aminopeptidase in various blister forming dermatoses]
Bone Resorption
Disappearing bone disease. A clinical and histological study.
Breast Neoplasms
A monoclonal antibody driven biodiagnostic system for the quantitative screening of breast cancer.
Inhibition of the proliferation, migration, and invasion of human breast cancer cells by leucine aminopeptidase 3 inhibitors derived from natural marine products.
Leucine aminopeptidase 3 promotes migration and invasion of breast cancer cells through upregulation of fascin and matrix metalloproteinases-2/9 expression.
Serum leucine aminopeptidase estimation: a sensitive prognostic indicator of invasiveness in breast carcinoma.
The combined action of two enzymes in human serum can mimic the activity of cathepsin B.
Vimentin plays an important role in the promotion of breast cancer cell migration and invasion by leucine aminopeptidase 3.
Carcinoma
Biological markers as an aid in the clinical management of patients with liver metastases.
Changes in serum acid and alkaline phosphatase and leucine aminopeptidase activities following massage of the prostate. Value in differentiating carcinoma from benign hyperplasia of the prostate.
Differences in the leucine aminopeptidase activity in extracts from human prostatic carcinoma and benign prostatic hyperplasia.
Disaccharidases, leucine aminopeptidase, and glucose uptake in intestinalized gastric mucosa and in gastric carcinoma.
ELEVATED SERUM LEUCINE AMINOPEPTIDASE ACTIVITY: CLINICAL SIGNIFICANCE IN PANCREATIC CARCINOMA.
FACS quantitation of leucine aminopeptidase and acid phosphatase on tumor-associated macrophages from metastatic and nonmetastatic mouse mammary tumors.
Histochemically demonstrable enzyme activities and their independence of the hormone receptor content in female breast carcinoma.
Leucine amino peptidase a better indicator of carcinoma of liver, biliary tract and pancreas.
Leucine aminopeptidase; its nonspecificity as a test for carcinoma of the pancreas.
Overexpression of leucine aminopeptidase 3 contributes to malignant development of human esophageal squamous cell carcinoma.
SERUM LACTIC DEHYDROGENASE, LEUCINE AMINOPEPTIDASE AND 5-NUCLEOTIDASE ACTIVITIES: OBSERVATION IN PATIENTS WITH CARCINOMA OF THE PANCREAS AND HEPATOBILIARY DISEASE.
Serum leucine amino peptidase activity in carcinoma of the stomach with metastases.
Serum leucine aminopeptidase activity: findings in carcinoma of the pancreas, pregnancy and other disorders.
Serum leucine aminopeptidase in carcinoma of pancreas and other diseases.
Special features of intestinal metaplasia and its relation to early gastric carcinoma in man: observation by a method in which leucine aminopeptidase activity is used.
Study of activities of arginase, hexosaminidase, and leucine aminopeptidase in prostate fluid.
The diagnostic value of determinations of serum leucine aminopeptidase concentrations in carcinoma of the pancreas.
The serum leucine aminopeptidase test: an appraisal of its value in diagnosis of carcinoma of pancreas.
[Alkaline phosphatase and leucine aminopeptidase in untreated carcinoma of the endometrium]
[Diagnostic value of biochemical tumor markers in serum of patients with cancer of the ovary]
[Histochemical observations on leucine aminopeptidase activity in cervical carcinoma.]
[Markers of carcinoma of the ovary: serum cystine aminopeptidase and leucine aminopeptidase, reliable diagnostic parameters?]
Carcinoma, Ductal
Histochemically demonstrable enzyme activities and their independence of the hormone receptor content in female breast carcinoma.
Carcinoma, Hepatocellular
Enzyme histochemical study on hepatoma--the relation between enzyme activity and histological type.
Estimation of leucine aminopeptidase and 5-nucleotidase increases alpha-fetoprotein sensitivity in human hepatocellular carcinoma cases.
Expression of leucine aminopeptidase 3 (LAP3) correlates with prognosis and malignant development of human hepatocellular carcinoma (HCC).
In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe.
In vivo imaging via a red-emitting fluorescent probe to diagnosing liver cancer or drug-induced liver disease.
Leucine amino peptidase a better indicator of carcinoma of liver, biliary tract and pancreas.
Proteomic Analysis of Hepatocellular Carcinoma Tissues With Encapsulation Shows Up-regulation of Leucine Aminopeptidase 3 and Phosphoenolpyruvate Carboxykinase 2.
Carcinoma, Small Cell
Biological markers as an aid in the clinical management of patients with liver metastases.
Cardiovascular Diseases
RNA-sequencing analysis of differential gene expression associated with arterial stiffness.
Cataract
Proteases in the Emory mouse cataract.
[Variation of some enzymatic activities of the rat crystalline lens in experimental galactose cataract (lactate dehydrogenase, leucine aminopeptidase, phosphoglucose isomerase]
Celiac Disease
[Morphologic and histochemical study of the intestinal mucosa in celiac disease. Leucine aminopeptidase behavior in gluten intolerance]
Chemical and Drug Induced Liver Injury
In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe.
Chickenpox
[Behavior of leucine aminopeptidase in the blood of individuals with measles, scarlet fever and chickenpox]
Cholestasis
Effect of sodium tauroursodeoxycholate on phalloidin-induced cholestasis in rats.
Triton-polyacrylamide gel electrophoresis and leucine aminopeptidase activity staining detect Triton-slowed bands including high-molecular-mass aminopeptidase N (CD13) isoform in cholestatic patient sera.
Value of serum alkaline phosphatase, aminotransferases, gamma-glutamyl transferase, leucine aminopeptidase, and bilirubin in the distinction between benign and malignant diseases causing jaundice and cholestasis: results from a prospective study.
[Comparative study of lipoprotein-X and leucine aminopeptidase in the diagnosis of cholestasis]
[Increased serum alkaline phosphatase induced by DT-5061, an oral contraceptive, in rats]
[The activity of cholestatic enzymes in viral hepatitis B]
Cholestasis, Intrahepatic
[Changes in hepatobiliary enzymes and its isoenzymes in intrahepatic cholestasis in pregnancy]
[Hypertension and bilateral stenosis of the renal artery associated with congenital hypoplasia of the intrahepatic bile ducts (author's transl)]
Cholesteatoma
Clinical and biochemical studies of bone destruction in cholesteatoma.
Choriocarcinoma
Cystine animopeptidase and leucine aminopeptidase of choriocarcinoma cells grown in culture.
The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma.
Clonorchiasis
Molecular identification and characterization of leucine aminopeptidase 2, an excretory-secretory product of Clonorchis sinensis.
Coccidiosis
[Alteration of enzyme activities in serum of Eimeria stiedai infected rabbits (author's transl)]
Colitis, Ulcerative
Leucine aminopeptidase with special reference to ulcerative colitis.
Communicable Diseases
Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations.
Polymorphisms in ERAP1 and ERAP2 are shared by Caninae and segregate within and between random- and pure-breeds of dogs.
COVID-19
Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms.
ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19?
Immunogenetic Predictors of Severe COVID-19.
Crohn Disease
A functional variant in ERAP1 predisposes to multiple sclerosis.
Brief Report: Functional Interaction of Endoplasmic Reticulum Aminopeptidase 2 and HLA-B27 Activates the Unfolded Protein Response.
Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection.
Increased proteolysis and leucine aminopeptidase activity in faeces of patients with Crohn's disease.
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
Cystadenoma, Serous
[A comparison of the enzyme activities of alkaline and acid phosphatase, lactic acid dehydrogenase and leucine aminopeptidase from the wall and fluid of human ovarian follicles, cysts and serous cystadenomas (author's transl)]
Cystic Fibrosis
The experience with the foetal diagnosis of the cystic fibrosis in the second and first trimester.
Cysts
Essential Role for an M17 Leucine Aminopeptidase in Encystation of Acanthamoeba castellanii.
Leucine Aminopeptidase in Eggs of the Soybean Cyst Nematode Heterodera glycines.
[A comparison of the enzyme activities of alkaline and acid phosphatase, lactic acid dehydrogenase and leucine aminopeptidase from the wall and fluid of human ovarian follicles, cysts and serous cystadenomas (author's transl)]
Cytomegalovirus Infections
Serum leucine aminopeptidase for monitoring viral infections with plasmacytoid reaction.
Dental Calculus
[Leucine aminopeptidase and aminotransferase activity in human dental calculus, dental deposit and saliva]
Dental Deposits
[Leucine aminopeptidase and aminotransferase activity in human dental calculus, dental deposit and saliva]
Dermatitis
[Leucine aminopeptidase activity in blood serum & blister content. II. Studies in patients with psoriasis, neurodermatitis diffusa, dermatitis, eczema & other dermatoses.]
Diabetes Mellitus, Type 1
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
Diabetic Nephropathies
Clinical significance of urinary enzymes in diabetic nephropathy.
Digestive System Diseases
Electrophoretic patterns of serum leucine aminopeptidase in patients with pancreatic and hepatobiliary disease.
SERUM LACTIC DEHYDROGENASE, LEUCINE AMINOPEPTIDASE AND 5-NUCLEOTIDASE ACTIVITIES: OBSERVATION IN PATIENTS WITH CARCINOMA OF THE PANCREAS AND HEPATOBILIARY DISEASE.
Serum leucine aminopeptidase in pancreatic and hepatobiliary diseases.
Triton-polyacrylamide gel electrophoresis and leucine aminopeptidase activity staining detect Triton-slowed bands including high-molecular-mass aminopeptidase N (CD13) isoform in cholestatic patient sera.
[DIAGNOSTIC VALUE OF THE ENZYME LEUCINE AMINOPEPTIDASE. II. INVESTIGATION IN CHOLOSTATIC, HEPATOBILIARY DISEASES AND OTHER DIGESTIVE TRACT PROCESSES.]
[ELECTROPHORETIC FRACTIONATION OF "CELLOGEL" OF BLOOD LEUCINE AMINOPEPTIDASE IN HEPATOBILIARY DISEASES.]
[MECHANISM OF ABNORMAL SERUM LAP ISOZYME IN HEPATOBILIARY DISORDERS AS INDICATED BY URINARY LEUCINE AMINOPEPTIDASE (LAP) ZYMOGRAM.]
[SIGNIFICANCE OF SERUM LEUCINE AMINOPEPTIDASE ISOZYMES IN HEPATOBILIARY DISORDERS.]
Diphtheria
[Modification of beta-glucuronidase, leucine aminopeptidase and alkaline phosphatase activities by diphtheria toxin in experimental animals]
Duodenal Ulcer
Study of enzyme activities in the descending part of the duodenum in patients of duodenal ulcer.
Eclampsia
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.
Eczema
[Leucine aminopeptidase activity in blood serum & blister content. II. Studies in patients with psoriasis, neurodermatitis diffusa, dermatitis, eczema & other dermatoses.]
Elephantiasis, Filarial
Tissue localization of collagenase and leucine aminopeptidase in the bovine filarial parasite Setaria cervi.
Endometrial Neoplasms
Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system.
Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. Association with tumor grade and CA-125.
Possible involvement of adipocyte-derived leucine aminopeptidase via angiotensin II in endometrial carcinoma.
Serum cystine aminopeptidase and leucine aminopeptidase activity in women with benign and malignant uterine and ovarian tumors.
Eosinophilia
Clinical changes caused by the liver fluke Metorchis conjunctus in cats.
Epstein-Barr Virus Infections
Serum leucine aminopeptidase for monitoring viral infections with plasmacytoid reaction.
Esophageal Squamous Cell Carcinoma
Overexpression of leucine aminopeptidase 3 contributes to malignant development of human esophageal squamous cell carcinoma.
Essential Hypertension
The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.
Fascioliasis
Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep.
Fetal Death
Uteroplacental blood flow and uteroplacental shunt rates in normal and prolonged pregnancies in rats.
Fibrosarcoma
Enhanced expression of interferon-gamma-induced antigen-processing machinery components in a spontaneously occurring cancer.
Gallstones
Clinical and pathological studies in cattle with hepatic disease.
Gastrointestinal Neoplasms
Leucine aminopeptidase in gastrointestinal cancers.
Glucose Intolerance
Subacute thyroiditis associated with systemic multi-organ disorders.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
A new glucose-6-phosphate dehydrogenase deficiency variant, G6PD Mizushima, showing increases in serum ferritin and cytosol leucine aminopeptidase levels.
Glucosephosphate Dehydrogenase Deficiency
A new glucose-6-phosphate dehydrogenase deficiency variant, G6PD Mizushima, showing increases in serum ferritin and cytosol leucine aminopeptidase levels.
Granuloma
Effects of keratin on bone resorption in experimental otitis media.
Mononuclear phagocytes from carrageenan-induce granulomas. Isolation, cultivation, and characterization.
Streptozotocin diabetes: prolonged inflammatory response with delay in granuloma formation.
[Enzymehistochemical and immunopathological findings in the guinea pig lung after repeated doses of Freund's adjuvant (author's transl)]
Head and Neck Neoplasms
Serum leucine aminopeptidase in head and neck cancer.
[ENZYMES IN CLINICAL PRACTICE: LEUCINE AMINOPEPTIDASE. ITS IMPORTANCE IN DIAGNOSIS OF BILIARY DISEASES AND IN CASES OF CANCER OF THE HEAD OF THE PANCREAS.]
HELLP Syndrome
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.
Hepatitis
[Changes in serum leucine aminopeptidase activity (expressed in U./G.R.) in children with contagious hepatitis]
[Changes in the serum phosphohexose isomerase and leucine aminopeptidase levels during lysozyme treatment of viral hepatitis in childhood]
[Effect of glucocorticoids (GCS) on the enzyme activity in viral hepatitis (VH). II. Isoenzymatic profile of leucine aminopeptidase (LAP) and glycyl aminopeptidase (GAP) of blood serum]
[Effects of glucocorticoids on enzyme activity in viral hepatitis. I. Behavior of serum leucine aminopeptidase and glycine aminopeptidase]
[Leucine aminopeptidase and cystinyl aminopeptidase activity of serum during the course of viral hepatitis, with reference to the effect of cortico therapy]
[Leucine aminopeptidase in the differential diagnosis of viral hepatitis and mechanical jaundice]
[Serum beta-glucuronidase and leucine aminopeptidase in the diagnosis of hepatitis and cirrhosis.]
[Suitability of "classical" leucine aminopeptidase (LAP) as indicator enzyme in hepatitis epidemica acuta. Differentiation between leucine aminopeptidase and arylamidase in hepatobiliary illnesses]
[The activity of leucine aminopeptidase in different clinical course types of hepatitis in childhood]
Hepatitis A
Leucine aminopeptidase activity in infectious hepatitis.
[Blood and urinary leucinaminopeptidase (LAP) levels in infectious hepatitis in childhood]
[Determination of serum leucine aminopeptidase by a new method in children with latent infectious hepatitis]
[On the serum L-leucine aminopeptidase activity in children with acute infectious hepatitis.]
Hepatitis, Chronic
Serum levels of secretory immunoglobulin A in liver disease.
[The significance of serum gamma-glutamyl transpeptidase determination in the differentiation of icterus of various etiologies]
Herpes Simplex
[Leucine aminopeptidase activity in a simulation of keratitis due to serotypes I and II of the herpes simplex virus]
Histiocytic Sarcoma
Prognostic evaluation of serum leucine aminopeptidase in malignancy of lymphoreticular and haemopoietic cell lines in children, with special reference to malignant histiocytosis of the intestine.
HIV Infections
Bestatin-mediated inhibition of leucine aminopeptidase may hinder HIV infection.
Hydatidiform Mole
Serum leucine aminopeptidase activity in normal pregnancy and in patients with hydatidiform mole.
Hypersensitivity
Enhancement of delayed-type hypersensitivity by bestatin, an inhibitor of aminopeptidase B and leucine aminopeptidase.
Small molecular microbial products enhancing immune response.
Hypersensitivity, Delayed
Increased sensitivity of IL2-dependent cultured T cells and enhancement of in vitro IL2 production by human lymphocytes treated with Bestatin.
New microbial secondary metabolites under preclinical development for cancer treatment.
Hypertension
Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women.
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.
Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension.
Hypertension, Portal
Activity of brush border membrane enzymes in proximal jejunum of portal hypertensive rats.
Hyperthyroidism
[Aminopeptidases in the serum and urine of patients with hyperthyroidism]
[Cytochemical properties of peripheral blood neutrophils in patients with hyperthyroidism]
Immune System Diseases
Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.
Infections
A Complex Array of Proteins Related to the Multimeric Leucine Aminopeptidase of Tomato.
A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?
Decreased activity of brush border membrane-bound digestive enzymes in small intestines from pigs experimentally infected with porcine epidemic diarrhea virus.
Does Convit vaccine (BCG + Mycobacterium leprae) afford protection against biochemical changes in renal brush border membrane in experimental leprosy?
Effects of size of Trichostrongylus colubriformis infections on histopathology of the mucosa along the whole small intestine in rabbits.
Endoplasmic reticulum aminopeptidase 2 (ERAP2) haplotypes play a role in modulating susceptibility to HIV infection.
Evaluation of recombinant SjLAP and SjFBPA in detecting antibodies to Schistosoma japonicum.
Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.
Leucine aminopeptidase is an immunodominant antigen of Fasciola hepatica excretory and secretory products in human infections.
Leucine aminopeptidase, Significance of serum elevation in bilharziasis.
Localization and post-translational processing of the wound-induced leucine aminopeptidase proteins of tomato.
Pseudomonas aeruginosa Leucine Aminopeptidase Influences Early Biofilm Composition and Structure via Vesicle-Associated Antibiofilm Activity.
Renal brushborder membrane vesicle. Study of marker enzymes and uptake of nutrients in Mycobacterium leprae infected mice.
The induction of tomato leucine aminopeptidase genes (LapA) after Pseudomonas syringae pv. tomato infection is primarily a wound response triggered by coronatine.
The recombinant gut-associated M17 leucine aminopeptidase in combination with different adjuvants confers a high level of protection against Fasciola hepatica infection in sheep.
Urinary leucine aminopeptidase in bilharziasis.
[Antibody responses to leucine aminopeptidase in Schistosoma japonicum infection].
[Serum activity of leucine aminopeptidase in lymphotropic infections and in malignant lymphomas]
[Significance of the study of leucine aminopeptidase activity of the blood serum in patients with suppurative surgical infections]
Infectious Mononucleosis
[Evaluation of leucine aminopeptidase activity (LAP) in infectious mononucleosis]
Influenza, Human
A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?
Intervertebral Disc Degeneration
Correlation Between Proteolytic Enzymes and Microangiogenesis in Degenerative Intervertebral Disc Nucleus.
Keratitis
[Leucine aminopeptidase activity in a simulation of keratitis due to serotypes I and II of the herpes simplex virus]
Ketosis
Tubular dysfunction in type I diabetes mellitus.
Kidney Diseases
[ON LEUCINE AMINOPEPTIDASE IN URINE IN KIDNEY DISEASES.]
[Urine leucine aminopeptidase in kidney diseases]
Leishmaniasis
Structural and Functional Basis of Potent Inhibition of Leishmanial Leucine Aminopeptidase by Peptidomimetics.
Leprosy, Lepromatous
Urinary excretion of renal brush-border enzymes in lepromatous leprosy--a preliminary investigation.
Leptospirosis
Clinical and pathological studies in cattle with hepatic disease.
leucyl aminopeptidase deficiency
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.
Brief Report: Functional Interaction of Endoplasmic Reticulum Aminopeptidase 2 and HLA-B27 Activates the Unfolded Protein Response.
Leukemia
Enzyme activity in mice with transplantable leukemia.
Histochemical study of leucine aminopeptidase in leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
CHROMATOGRAPHIC STUDIES ON LEUCINE AMINOPEPTIDASE IN NORMAL HUMAN GRANULOCYTES AND IN CELLS OF ACUTE AND CHRONIC MYELOID LEUKEMIA.
Leukoplakia
[The effect of antioxidants on the activity of acid hydrolases in blood leukocytes from patients with leukoplakia of mouth mucosa]
Lipidoses
Clinical and pathological studies in cattle with hepatic disease.
Liver Cirrhosis
Serum levels of secretory immunoglobulin A in liver disease.
[Effect of hydrocortisone on the activity of plasma and hepatic tissue enzymes. I. Leucylaminopeptidase (LAP) and glycylaminopeptidase (GAP) activity in experimental liver cirrhosis and mechanical jaundice in rats]
Liver Cirrhosis, Experimental
[Effect of hydrocortisone on the activity of plasma and hepatic tissue enzymes. I. Leucylaminopeptidase (LAP) and glycylaminopeptidase (GAP) activity in experimental liver cirrhosis and mechanical jaundice in rats]
Liver Diseases
High serum levels of secretory IgA in liver disease: possible liver origin of the circulating secretory component.
Multiple forms of gamma-glutamyltransferase: a clinical study.
Rational design of a fluorescent probe for the detection of LAP and its application in drug-induced liver injury.
Sephadex gel filtration of gamma-glutamyl-transpeptidase, alkaline phosphatase and leucine aminopeptidase in the serum of patients affected by various liver diseases.
SERUM LEUCINE AMINOPEPTIDASE IN LIVER DISEASES.
Subacute thyroiditis associated with systemic multi-organ disorders.
[LEUCINAMINOPEPTIDASE ACTIVITY OF THE BLOOD OF PATIENTS WITH VARIOUS TYPES OF LIVER DISEASES.]
[Serum activity of leucine aminopeptidase in lymphotropic infections and in malignant lymphomas]
Liver Diseases, Alcoholic
Beta-hexosaminidase, leucine aminopeptidase, cystidyl aminopeptidase, hepatic enzymes and bilirubin in serum of chronic alcoholics with acute ethanol intoxication.
Liver Failure
Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies.
Liver Neoplasms
A ratiometric fluorescent probe based on quinoline for monitoring and imaging of Leucine aminopeptidase in liver tumor cells.
A Ratiometric Fluorescent Probe for Monitoring Leucine Aminopeptidase in Living Cells and Zebrafish Model.
In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe.
Lupus Erythematosus, Systemic
Serum leucine aminopeptidase as an activity indicator in systemic lupus erythematosus: a study of 46 consecutive cases.
[The value of urinary enzyme determinations in systemic lupus erythematosus (author's transl)]
Lymphadenitis
Increased activities of cytosol aminopeptidase and lactate dehydrogenase in serum originate from lymphocytes in necrotizing lymphadenitis.
[Serum activity of leucine aminopeptidase in lymphotropic infections and in malignant lymphomas]
Lymphatic Diseases
[Marked dissociation of leucine aminopeptidase activities by the use of 2 different substrates--application of the methods to lymphatic diseases]
Lymphocytic Choriomeningitis
Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses.
Lymphoma
[Serum activity of leucine aminopeptidase in lymphotropic infections and in malignant lymphomas]
Lymphopenia
[Subchronic toxicity of gamma-Falisan-Universal dry dressing agent to rats]
Malabsorption Syndromes
The activities of alanine aminopeptidase, leucine aminopeptidase, proline dipeptidase and prolyl dipeptidase in the mucosa of the small intestine. Investigations on normal children and patients with the malabsorption syndrome.
Malaria
Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development.
Enzymatic characteristics and preventive effect of leucine aminopeptidase against Echinococcus multilocularis.
In silico screening of novel inhibitors of M17 Leucine Amino Peptidase (LAP) of Plasmodium vivax as therapeutic candidate.
M17 leucine aminopeptidase of the human malaria parasite Plasmodium vivax.
Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin.
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.
The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: the importance of active site metal ions in the binding of substrates and inhibitors.
Malnutrition
Interaction of malnutrition and difluoromethylornithine-induced intestinal mucosal damage: degree of severity and subsequent recovery.
Measles
Increased cytosol aminopeptidase and lactate dehydrogenase in serum originating from lymphocytes in measles and rubella infection.
[Behavior of leucine aminopeptidase in the blood of individuals with measles, scarlet fever and chickenpox]
Melanoma
Spontaneous and induced differentiation of human melanoma cells.
Meningitis
Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.
Methemoglobinemia
Leucine aminopeptidase activity in plasma of rats, after combined carboxy- and methemoglobinemia.
Multiple Sclerosis
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
[Isolation and various properties of leucine aminopeptidase from biological fluids of patients with multiple sclerosis]
[Possible role of hydrolytic enzymes in the pathogenesis of multiple sclerosis]
[Prognostic significance of determining myelin leucine aminopeptidase activity in disseminated sclerosis]
Mumps
[Blood leucine aminopeptidase (LAP) in epidemic parotitis. Comparative evaluation with blood lipase and amylase in salivary and pancreatic localization of the parotitis virus]
Muscular Diseases
[Histochemical evidence of leucine aminopeptidase activity in human skeletal muscle in myopathies]
Musculoskeletal Diseases
Renal injury in patients with rheumatoid arthritis treated with gold.
Myocardial Infarction
Prognostic significance of serum leucine aminopeptidase in myocardial infarction with left ventricular failure.
[Aminopeptidases in the serum following myocardial infarct]
[The value of glycine peptidase, leucine aminopeptidase and -glutamyl transpeptidase determinations in distant diagnosis of myocardial infarction]
Neoplasm Metastasis
Inhibition of the proliferation, migration, and invasion of human breast cancer cells by leucine aminopeptidase 3 inhibitors derived from natural marine products.
Leucine amino peptidase a better indicator of carcinoma of liver, biliary tract and pancreas.
Leucine aminopeptidase 3 promotes migration and invasion of breast cancer cells through upregulation of fascin and matrix metalloproteinases-2/9 expression.
Serum leucine amino peptidase activity in carcinoma of the stomach with metastases.
Serum leucine aminopeptidase profile in cancers of gastro-intestinal tract with special reference to hepatic metastasis.
Transport mechanisms of bestatin in rabbit intestinal brush-border membranes: role of H+/dipeptide cotransport system.
Neoplasms
A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.
A near-infrared fluorescent probe for monitoring leucine aminopeptidase in living cells.
A new method to evaluate the enzyme-suppressing activity of a leucine aminopeptidase 3 inhibitor.
A ratiometric fluorescent probe based on quinoline for monitoring and imaging of Leucine aminopeptidase in liver tumor cells.
A Ratiometric Fluorescent Probe for Monitoring Leucine Aminopeptidase in Living Cells and Zebrafish Model.
A turn-on fluorescence probe based on aggregation-induced emission for leucine aminopeptidase in living cells and tumor tissue.
Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues.
An approach to malignant mammary phyllodes tumors detection.
Characterization of a monoclonal antibody defining a macrophage activation-specific cell surface antigen.
Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypes.
Comparison of methods of evaluating nephrotoxicity of cis-platinum.
Cytoenzymology of benign and malignant tumours of the corpus uteri. III. Alkaline phosphatase, non-specific esterase and leucine aminopeptidase.
Detection of leucine aminopeptidase activity in serum using surface-enhanced Raman spectroscopy.
Diagnosis of hepatocellular carcinoma in patients with liver cirrhosis using liver function assays.
Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma.
Effect of a rhodium complex on alterations of hepatic function in thioacetamide-induced hyperplastic noduligenesis in rats.
Electrochemical substrate for active profiling of cellular surface leucine aminopeptidase activity and drug resistance in cancer cells.
Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells.
Endoplasmic Reticulum Aminopeptidase 2, a common immunological link to adverse pregnancy outcomes and cancer clearance?
Enhanced cleavage of diaminopimelate-containing isopeptides by leucine aminopeptidase and matrix metalloproteinases in tumors: application to bioadhesive peptides.
Enhanced expression of interferon-gamma-induced antigen-processing machinery components in a spontaneously occurring cancer.
EpCAM associates with endoplasmic reticulum aminopeptidase 2 (ERAP2) in breast cancer cells.
Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. Association with tumor grade and CA-125.
Expression of Endoplasmic Reticulum Aminopeptidases in EBV-B Cell Lines from Healthy Donors and in Leukemia/Lymphoma, Carcinoma, and Melanoma Cell Lines.
FACS quantitation of leucine aminopeptidase and acid phosphatase on tumor-associated macrophages from metastatic and nonmetastatic mouse mammary tumors.
Highly sensitive fluorescence imaging of cancer with avidin-protease probe conjugate.
In Silico Screening for Novel Leucine Aminopeptidase Inhibitors with 3,4-Dihydroisoquinoline Scaffold.
Increased sensitivity of IL2-dependent cultured T cells and enhancement of in vitro IL2 production by human lymphocytes treated with Bestatin.
Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations.
Inhibition of the proliferation, migration, and invasion of human breast cancer cells by leucine aminopeptidase 3 inhibitors derived from natural marine products.
Inhibitory effects of Estracyt on R-3327 rat prostatic carcinoma.
Interaction between ERAP Alleles and HLA Class I Types Support a Role of Antigen Presentation in Hodgkin Lymphoma Development.
Leucine amino peptidase a better indicator of carcinoma of liver, biliary tract and pancreas.
Leucine amino peptidase levels in hepatic and certain gastro intestinal tract cancers.
Leucine aminopeptidase 3 promotes migration and invasion of breast cancer cells through upregulation of fascin and matrix metalloproteinases-2/9 expression.
Leucine aminopeptidase activity; observations in patients with cancer of the pancreas and other diseases.
Leucine aminopeptidase fragments from an ascites tumor.
Leucine aminopeptidase may contribute to the intrinsic resistance of cancer cells toward cisplatin as revealed by an ultrasensitive fluorescent probe.
Leucine aminopeptidase of neutrophils and lymphocytes in patients with cancer.
Leucine aminopeptidase, Significance of serum elevation in bilharziasis.
Macrophage activation in rat models of inflammation and arthritis: determination of markers of stages of activation.
Modulators of hERAP2 discovered by high-throughput screening.
Molecular mechanism of inflammatory response in mouse liver caused by exposure to CeCl(3).
Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing.
Near-Infrared Fluorescent Probe with Remarkable Large Stokes Shift and Favorable Water Solubility for Real-Time Tracking Leucine Aminopeptidase in Living Cells and In Vivo.
Neoplastic disorganization of pancreatic epithelial cell-cell relations. Role of basement membrane.
Peptide Trimming for MHC Class I Presentation by Endoplasmic Reticulum Aminopeptidases.
Polymorphisms in ERAP1 and ERAP2 are shared by Caninae and segregate within and between random- and pure-breeds of dogs.
Positioning of aminopeptidase inhibitors in next generation cancer therapy.
Prediction of portal vein invasion by hepatocellular carcinoma: a correlations between portal vein tumor thrombus and biochemical tests.
Prognostic evaluation of serum leucine aminopeptidase in malignancy of lymphoreticular and haemopoietic cell lines in children, with special reference to malignant histiocytosis of the intestine.
Prostaglandin E2, collagenase, and protease levels in culture of rat tumor.
Puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) binds and catalyzes PDK1, allowing VEGF-stimulated activation of S6K for endothelial cell proliferation and angiogenesis.
Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer.
Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.
Serum cystine aminopeptidase and leucine aminopeptidase activity in women with benign and malignant uterine and ovarian tumors.
Serum lactic dehydrogenase, leucine aminopeptidase and alkaline phosphatase in the diagnosis of cancer.
Serum leucine amino peptidase levels as a marker in testicular tumours.
Serum leucine aminopeptidase profile in cancers of gastro-intestinal tract with special reference to hepatic metastasis.
Significance of serum leucine aminopeptidase in tumours of female genital tract.
Significance of serum tumor markers in patients with carcinoma of the ovary.
Small molecular microbial products enhancing immune response.
The colorimetric determination of leucine aminopeptidase in urine and serum of normal subjects and patients with cancer and other diseases.
The effect of dietary n-3 and n-6 fatty acids on tumor necrosis factor-alpha production and leucine aminopeptidase levels in rat peritoneal macrophages.
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
Transport mechanisms of bestatin in rabbit intestinal brush-border membranes: role of H+/dipeptide cotransport system.
Tumor-associated macrophages of mouse mammary tumors. II. Differential distribution of macrophages from metastatic and nonmetastatic tumors.
Urinary leucine aminopeptidase in bilharziasis.
[Behavior of leucine aminopeptidase activity in blood serum in patients with malignant tumors in the mouth and neck area.]
[Biochemical evaluation of the leucine aminopeptidase content of malignant neoplasms of the female genital system]
[Comparison of methods for evaluating the nephrotoxicity of cisplatin]
[Cytology and enzymocytochemistry of nodose hyperplasia and cancer of the prostate]
[Diagnostic significance of serum leucine aminopeptidase, alkaline phosphatase and lactic dehydrogenase isozymes in liver and bile duct cancer]
[Diagnostic value of biochemical tumor markers in serum of patients with cancer of the ovary]
[DIAGNOSTIC VALUE OF THE ENZYME LEUCINE AMINOPEPTIDASE. 3. STUDY OF ITS ACTIVITY IN TUMORS AND OTHER NON-GASTROENTEROLOGIC DISEASES. ORIGIN OF SERUM L.A.P. ACTIVITY . FINAL CONSIDERATIONS.]
[ENZYMES IN CLINICAL PRACTICE: LEUCINE AMINOPEPTIDASE. ITS IMPORTANCE IN DIAGNOSIS OF BILIARY DISEASES AND IN CASES OF CANCER OF THE HEAD OF THE PANCREAS.]
[Enzymological study of prostatic cancer. I. Changes of serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase, glutamic pyruvic transaminase, glutamic oxalacetic transaminase activity and lactic dehydrogenase isoenzymes in prostatic cancer under anti-androgenic treatment, with special reference to prognosis]
[Enzymological study of prostatic cancer. II. Serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase activity and lactic dehydrogenase isoenzymes in prostatic cancer, with special reference to relation with stage and histological malignancy]
[Leucine aminopeptidase activity in some neoplasms of the female genital apparatus before and after irradiation]
[Leucine aminopeptidase activity in the urine of patients with malignant tumors.]
[Proceedings: Gamma-glutamyl transpeptidase, leucine aminopeptidase and alkaline phosphatase in the serum and urine in the diagnosis of neoplasms]
[STUDIES ON THE CAUSE OF INCREASED LEUCINE AMINOPEPTIDASE ACTIVITY IN THE URINE DURING TUMOR IRRADIATION.]
[Study on the behavior of leucine aminopeptidase in cancer of the uterine cervix]
[The leucine aminopeptidase (LAP) in tumor cells and its significance in destructive tumor growth]
[THE LEUCINE AMINOPEPTIDASE. ITS IMPORTANCE IN THE DIAGNOSIS OF BILIARY DISEASES AND IN CASES OF NEOPLASM OF THE HEAD OF THE PANCREAS.]
[The significance of serum leucine aminopeptidase (P-LAP) determination in the gynecological malignancies]
[Urological neoplasms and enzyme. IV. Studies on the alteration of lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, and total acid phosphatase activities and LDH isozymes in experimentally induced renal tumors with dimethylnitrosamine]
[Urological neoplasms and enzymes. V. Studies on the alteration of lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase activities and LDH isozymes in experimentally induced renal tumors with lead acetate]
Nephrotic Syndrome
Activity of serum enzymes in puromycin aminonucleoside-induced nephrotic syndrome.
Nervous System Diseases
[Leucine aminopeptidase activity in the cerebrospinal fluid in nervous system diseases]
[Results of clinical and immunoenzymatic studies of neurospecific leucine aminopeptidase in patients with neurologic disorders]
Neurodermatitis
[Leucine aminopeptidase activity in blood serum & blister content. II. Studies in patients with psoriasis, neurodermatitis diffusa, dermatitis, eczema & other dermatoses.]
Obesity
Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity.
Odontogenic Cysts
Enzyme histochemical studies on the formation of hyalin bodies in the epithelium of odontogenic cysts.
Odontogenic keratocysts: a clinical and histological study with special reference to enzyme histochemistry.
Ovarian Neoplasms
Inhibition of leucine aminopeptidase 3 suppresses invasion of ovarian cancer cells through down-regulation of fascin and MMP-2/9.
Pancreatic Diseases
[Clinical significance of serum leucine aminopeptidase activity in liver, bile duct, and pancreatic diseases.]
[Clinical significance of serum leucine aminopeptidase in hepatobiliary and pancreatic diseases.]
[The behavior of leucine aminopeptidase and other enzymes in the blood serum in liver, biliary and pancreatic diseases.]
[The heterogenecity of leucine aminopeptidase. Studies on the organs and serum in liver, biliary tract and pancreatic diseases.]
Pancreatic Neoplasms
Leucine aminopeptidase activity; observations in patients with cancer of the pancreas and other diseases.
Pancreatitis
LEUCINE AMINOPEPTIDASE IN THE PANCREATIC JUICE DURING ETHIONINE PANCREATITIS.
Parasitic Diseases
Enzymatic characteristics and preventive effect of leucine aminopeptidase against Echinococcus multilocularis.
Parotitis
[Blood leucine aminopeptidase (LAP) in epidemic parotitis. Comparative evaluation with blood lipase and amylase in salivary and pancreatic localization of the parotitis virus]
Persistent Infection
Definitive host influences the proteomic profile of excretory/secretory products of the trematode Echinostoma caproni.
The ERAP gene is associated with HCV chronic infection in a Chinese Han population.
Placental Insufficiency
[Proteolytic activity of fetoplacental complex in norm and pathology].
Plasmacytoma
Enzyme activity in mice with transplantable leukemia.
[Serum activity of leucine aminopeptidase in lymphotropic infections and in malignant lymphomas]
Pleural Effusion
[Gamma-glutamyl transferase, leucine aminopeptidase and creatine kinase in the pleural fluid and serum of patients with pleural effusion of neoplastic and infectious origin]
[On lactate dehydrogenase and leucine aminopeptidase of the serum, pleural effusions and ascites determined by electrophoresis]
Pre-Eclampsia
A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk.
Association of ERAP2 gene variants with risk of pre-eclampsia among Iranian women.
Association Study of Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 and 2 Genes in Iranian Women with Preeclampsia.
Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study.
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.
Leucine aminopeptidase activity in maternal, cord blood and placenta of normal pregnancy and in pre-eclampsia.
The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.
[Serum leucine aminopeptidase activity in threatened abortion, prolonged pregnancy and pregnancy toxemias]
Pregnancy, High-Risk
[Clinical significance of serum AKP, HSAP, LAP and gamma-GT determination in high-risk pregnancy]
Pregnancy, Prolonged
[Activity of oxytocinase, leucine aminopeptidase and glutamyl-transferase in term pregnancy and prolonged pregnancy]
[Serum leucine aminopeptidase activity in threatened abortion, prolonged pregnancy and pregnancy toxemias]
[Study of leucine aminopeptidase activity in prolonged pregnancy]
Prostatic Hyperplasia
Differences in the leucine aminopeptidase activity in extracts from human prostatic carcinoma and benign prostatic hyperplasia.
Prostatic Neoplasms
Biochemical methods for predicting metastatic ability of prostatic cancer utilizing the dunning R-3327 rat prostatic adenocarcinoma system as a model.
[Enzymological study of prostatic cancer. I. Changes of serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase, glutamic pyruvic transaminase, glutamic oxalacetic transaminase activity and lactic dehydrogenase isoenzymes in prostatic cancer under anti-androgenic treatment, with special reference to prognosis]
[Enzymological study of prostatic cancer. II. Serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase activity and lactic dehydrogenase isoenzymes in prostatic cancer, with special reference to relation with stage and histological malignancy]
[Enzymological study of prostatic cancer. V. Alterations in the serum acid and alkaline phosphatase and leucine aminopeptidase activities following massage of the prostate]
Prostatitis
The response of seven prostatic fluid components to prostatic disease.
Proteinuria
Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats.
Psoriasis
Leucine aminopeptidase and naphthylamidases in human epidermis. II. Biochemical and histochemical data in psoriasis and basaliomas.
The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset.
The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
[Activity of peptide hydrolases and trypsin inhibitor in psoriasis]
[Leucine aminopeptidase activity in blood serum & blister content. II. Studies in patients with psoriasis, neurodermatitis diffusa, dermatitis, eczema & other dermatoses.]
Renal Insufficiency
Urinary excretion of enzymes in cirrhotics with renal failure.
Rotavirus Infections
Effect of orally administered epidermal growth factor on intestinal recovery of neonatal pigs infected with rotavirus.
Rubella
Increased cytosol aminopeptidase and lactate dehydrogenase in serum originating from lymphocytes in measles and rubella infection.
Sarcoma
Cytoenzymology of benign and malignant tumours of the corpus uteri. III. Alkaline phosphatase, non-specific esterase and leucine aminopeptidase.
Scarlet Fever
[Behavior of leucine aminopeptidase in the blood of individuals with measles, scarlet fever and chickenpox]
Schistosomiasis
Evaluation of recombinant SjLAP and SjFBPA in detecting antibodies to Schistosoma japonicum.
Leucine aminopeptidase, Significance of serum elevation in bilharziasis.
Urinary leucine aminopeptidase in bilharziasis.
Schistosomiasis japonica
Evaluation of recombinant SjLAP and SjFBPA in detecting antibodies to Schistosoma japonicum.
[Antibody responses to leucine aminopeptidase in Schistosoma japonicum infection].
Seminoma
Serum leucine amino peptidase levels as a marker in testicular tumours.
Skin Diseases
[Leucine aminopeptidase activity in blood serum & blister content. II. Studies in patients with psoriasis, neurodermatitis diffusa, dermatitis, eczema & other dermatoses.]
[Leucine aminopeptidase in various blister forming dermatoses]
[ON ELECTROPHORETIC LOCALIZATION OF LEUCINE AMINOPEPTIDASE IN THE SERUM IN DERMATOSES USING AGAR GEL.]
Skin Diseases, Vesiculobullous
Histochemical study of bullous dermatoses. II. Leucine aminopeptidase.
Spondylitis
A functional variant in ERAP1 predisposes to multiple sclerosis.
Substantial Influence of ERAP2 on the HLA-B*40:02 Peptidome. Implications for HLA-B*27-negative Ankylosing Spondylitis.
Spondylitis, Ankylosing
Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.
Association of the genetic variants in the endoplasmic reticulum aminopeptidase 2 gene with ankylosing spondylitis susceptibility.
ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population.
ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients.
ERAP2 functional knockout in humans does not alter surface heavy chains or HLA-B27, inflammatory cytokines or endoplasmic reticulum stress markers.
ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients.
Functional Interaction of the Ankylosing Spondylitis Associated Endoplasmic Reticulum Aminopeptidase 2 with the HLA-B*27 Peptidome in Human Cells.
Lack of Associations between Endoplasmic Reticulum Aminopeptidase 2 Gene Polymorphisms and Ankylosing Spondylitis: A Meta-analysis with Trial Sequential Analysis.
Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome.
Substantial Influence of ERAP2 on the HLA-B*40:02 Peptidome. Implications for HLA-B*27-negative Ankylosing Spondylitis.
The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.
The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies.
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies.
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
Starvation
Age-related response of the small intestine to severe starvation and refeeding in rats.
The changes in the biochemical compositions and enzymatic activities of rotifer (Brachionus plicatilis, Müller) and Artemia during the enrichment and starvation periods.
Stomach Neoplasms
The histochemical studies on leucine aminopeptidase activity of human gastric cancers.
Testicular Neoplasms
Serum leucine amino peptidase levels as a marker in testicular tumours.
Tetanus
[BEHAVIOR OF LEUCINE AMINOPEPTIDASE IN THE BLOOD OF INDIVIDUALS WITH TETANUS TREATED WITH TETANUS ANTISERUM.]
Toxemia
[Statistical analysis of urinary estriol (U-E3), serum leucine aminopeptidase (LAP) and heat stable alkaline phosphatase (HSAP) in toxemia]
Trypanosomiasis
[MALIC DEHYDROGENASE, LEUCINE AMINOPEPTIDASE AND SUCCINIC DEHYDROGENASE ACTIVITY IN THE BLOOD OF THE GUINEA PIG WITH EXPERIMENTAL TRYPANOSOMIASIS DUE TO TRYPANOSOMA CRUZI.]
Tuberculosis
Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese.
The Activity of a Hexameric M17 Metallo-Aminopeptidase Is Associated With Survival of Mycobacterium tuberculosis.
Tuberculosis, Pulmonary
Enzyme levels in bronchoalveolar lavage fluid and serum of active pulmonary tuberculosis patients.
Urinary Bladder Neoplasms
[Enzymological study of bladder tumor. I. Serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase, glutamic pyruvic transaminase, glutamic oxalacetic transaminase activities and LDH isoenzymes: the relations with stage and histological grade]
Urologic Diseases
[Studies on leucine aminopeptidase (LAP) in urological diseases. I. Changed in LAP activity in renal homotransplants]
[Studies on leucine aminopeptidase (LAP) in urological diseases. II. Early diagnosis of rejection reactions]
Urologic Neoplasms
[Urological neoplasms and enzyme. IV. Studies on the alteration of lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, and total acid phosphatase activities and LDH isozymes in experimentally induced renal tumors with dimethylnitrosamine]
[Urological neoplasms and enzymes. V. Studies on the alteration of lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase activities and LDH isozymes in experimentally induced renal tumors with lead acetate]
Urticaria
[Serum and urinary leucine aminopeptidase (LAP) activity in patients with chronic allergic urticaria and in healthy subjects]
Uterine Cervical Neoplasms
Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population.
[Study on the behavior of leucine aminopeptidase in cancer of the uterine cervix]
Uterine Neoplasms
Significance of serum tumor markers in patients with carcinoma of the ovary.
Uveitis
Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis.
[On the leucine aminopeptidase activity of the aqueous humor in the course of experimental anaphylactic uveitis. (Experimental note)]
Virus Diseases
Endoplasmic reticulum aminopeptidase 2 (ERAP2) haplotypes play a role in modulating susceptibility to HIV infection.
Peptide Trimming for MHC Class I Presentation by Endoplasmic Reticulum Aminopeptidases.
Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.
Serum leucine aminopeptidase for monitoring viral infections with plasmacytoid reaction.
Vitiligo
Serum Leucine Amino Peptidase Activity in Vitiligo.