Disease on EC 3.3.2.6 - leukotriene-A4 hydrolase

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DISEASE
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Aberrant Crypt Foci
Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model.
Acute Coronary Syndrome
Biomarkers and Bioassays for Cardiovascular Diseases: Present and Future.
Acute Lung Injury
Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.
Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung.
Adenocarcinoma
Leukotriene A4 hydrolase as a target for cancer prevention and therapy.
Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin.
Anthrax
The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors.
Arthritis
The Interrelationship between Leukotriene B4 and Leukotriene-A4-Hydrolase in Collagen/Adjuvant-Induced Arthritis in Rats.
Aspergillosis
Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.
Asthma
ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos.
An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Candidate gene analysis of asthma in a population of Arab descent: a case-control study in Jordan.
Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats.
Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma.
Eosinophils Express LTA4 Hydrolase and Synthesize LTB4; Important for Asthma Pathogenesis?
Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma.
Leukotriene B4 receptor locus gene characterisation and association studies in asthma.
Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase.
Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy.
Quantitation of leukotriene B(4) in human sputum as a biomarker using UPLC-MS/MS.
Studies on linkage and association of atopy with the chromosomal region 12q13-24.
The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos.
The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility.
Atherosclerosis
Combined PET/DCE-MRI in a Rabbit Model of Atherosclerosis: Integrated Quantification of Plaque Inflammation, Permeability, and Burden During Treatment With a Leukotriene A4 Hydrolase Inhibitor.
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.
Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
Leukotriene A4 hydrolase haplotype, diet and atherosclerosis: a twin study.
Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: The Athero-Express Genomics Study.
[Study on the association between leukotriene A4 hydrolase gene polymorphism and ischemic stroke].
Carcinogenesis
Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors.
Leukotriene A4 hydrolase as a target for cancer prevention and therapy.
Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin.
LTA4H regulates cell cycle and skin carcinogenesis.
Carcinoma
Mass Spectrometric Analysis Identifies AIMP1 and LTA4H as FSCN1-Binding Proteins in Laryngeal Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Mass Spectrometric Analysis Identifies AIMP1 and LTA4H as FSCN1-Binding Proteins in Laryngeal Squamous Cell Carcinoma.
Cardiovascular Diseases
Expression Analysis of Leukotriene-Inflammatory Gene Interaction Network in Patients with Coronary Artery Disease.
Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.
Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase.
Chemical and Drug Induced Liver Injury
Adjunctive dexamethasone for the treatment of HIV-uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype (LAST ACT): Study protocol for a randomised double blind placebo controlled non-inferiority trial.
Coinfection
Coupling of recombinant 5-lipoxygenase and leukotriene A4 hydrolase activities and transcellular metabolism of leukotriene A4 in Sf9 insect cells.
Colitis
Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase.
Colonic Neoplasms
Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy.
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase.
Colorectal Neoplasms
Inhibition of LTA4H by bestatin in human and mouse colorectal cancer.
Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy.
Coronary Artery Disease
Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
Crohn Disease
The Polymorphism rs17525495 of LTA4H Is Associated with Susceptibility of Crohn's Disease instead of Intestinal Tuberculosis in a Chinese Han Population.
Cystic Fibrosis
Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis.
Dermatitis
Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis.
Dermatitis, Atopic
Leukotriene A4 hydrolase in peripheral leukocytes of patients with atopic dermatitis.
Dermatitis, Contact
Leukotriene B?-leukotriene B? receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8? T cells.
Gastroesophageal Reflux
Diagnostic Utility of Major Basic Protein, Eotaxin-3, and Leukotriene Enzyme Staining in Eosinophilic Esophagitis.
Glioma
5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines.
Glomerulonephritis
Gene expression of 5-lipoxygenase and LTA4 hydrolase in renal tissue of nephrotic syndrome patients.
HIV Infections
Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis.
Hyperlipidemias
Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk.
Hypersensitivity
The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility.
Hypertension
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension.
Idiopathic Pulmonary Fibrosis
Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung.
Immune Reconstitution Inflammatory Syndrome
Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV.
Infections
Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects.
Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.
Mycobacterial infections and the inflammatory seesaw.
Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection.
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.
Inflammatory Bowel Diseases
Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase.
Colonic expression of leukotriene-pathway enzymes in inflammatory bowel diseases.
Leprosy, Multibacillary
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.
Leukemia
Co-localization of leukotriene a4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils.
Inhibition of leukotriene synthesis by azelastine.
Lung Diseases
Genetic regulation of expression of leukotriene A4 hydrolase.
MMP generated matrikines.
Lung Injury
[Pathogenic role of leukotriene B4 in pulmonary microvascular endothelial cell hyper- permeability induced by one lung ventilation in rabbits].
Lung Neoplasms
Lung cancer cell lines inhibit leukotriene B4 production by human polymorphonuclear leukocytes at the level of phospholipase A2.
Lymphoma
Germline genetics of cancer of unknown primary (CUP) and its specific subtypes.
Melanoma
Human melanoma cells generate leukotrienes B4 and C4 from leukotriene A4.
Mutation analysis and gene expression profiling of ocular melanomas in cats.
Tissue-based microarray expression of genes predictive of metastasis in uveal melanoma and differentially expressed in metastatic uveal melanoma.
Meningitis, Bacterial
LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome.
Myocardial Infarction
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction.
Biomarkers and Bioassays for Cardiovascular Diseases: Present and Future.
The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility.
Neoplasm Metastasis
Tissue-based microarray expression of genes predictive of metastasis in uveal melanoma and differentially expressed in metastatic uveal melanoma.
Neoplasms
Expression Analysis of Leukotriene-Inflammatory Gene Interaction Network in Patients with Coronary Artery Disease.
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.
Gene polymorphisms in patients with pulmonary tuberculosis from Mozambique.
Immune regulatory functions of human beta-defensin-2 in odontoblast-like cells.
Leukotriene A4 hydrolase as a target for cancer prevention and therapy.
Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin.
Leukotriene A4 hydrolase: an emerging target of natural products for cancer chemoprevention and chemotherapy.
Leukotriene B4.
LTA4H regulates cell cycle and skin carcinogenesis.
Lung cancer cell lines inhibit leukotriene B4 production by human polymorphonuclear leukocytes at the level of phospholipase A2.
Positioning of aminopeptidase inhibitors in next generation cancer therapy.
Potential for a localized immune response by the ruminal epithelium in nonpregnant heifers following a short-term subacute ruminal acidosis challenge.
Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4 hydrolase.
The human leukotriene A4 hydrolase gene is expressed in two alternatively spliced mRNA forms.
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase.
Nephrotic Syndrome
5-Lipoxygenase and leukotriene A4 hydrolase expression in primary nephrotic syndrome.
Gene expression of 5-lipoxygenase and LTA4 hydrolase in renal tissue of nephrotic syndrome patients.
Neuroblastoma
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.
Pancreatic Neoplasms
Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4 hydrolase.
Pneumonia
Genetic regulation of expression of leukotriene A4 hydrolase.
In Vivo Two-Photon Fluorescence Imaging of the Activity of the Inflammatory Biomarker LTA4H in a Mouse Pneumonia Model.
Prostatic Neoplasms
Associations between arachidonic acid metabolism gene polymorphisms and prostate cancer risk.
Pruritus
Potential new therapeutic targets for pathological pruritus.
Psoriasis
Cyclosporin A down-regulates the LTA4 hydrolase level in human keratinocyte cultures.
Significance of leukotriene-A4 hydrolase in the pathogenesis of psoriasis.
Pulmonary Arterial Hypertension
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension.
Pulmonary Disease, Chronic Obstructive
Leukotriene A4 hydrolase: an anti-inflammatory role for a proinflammatory enzyme.
The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.
Ultrapressure liquid chromatography-tandem mass spectrometry assay using atmospheric pressure photoionization (UPLC-APPI-MS/MS) for quantification of 4-methoxydiphenylmethane in pharmacokinetic evaluation.
Pulmonary Emphysema
Effect of the leukotriene A4 hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema.
Skin Neoplasms
LTA4H regulates cell cycle and skin carcinogenesis.
Stroke
Association of ALOX5, LTA4H and LTC4S gene polymorphisms with ischemic stroke risk in a cohort of Chinese in east China.
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.
Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population.
[Study on the association between leukotriene A4 hydrolase gene polymorphism and ischemic stroke].
Tuberculosis
An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection.
Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in Eastern China.
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.
The Polymorphism rs17525495 of LTA4H Is Associated with Susceptibility of Crohn's Disease instead of Intestinal Tuberculosis in a Chinese Han Population.
Tuberculosis, Lymph Node
Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in Eastern China.
Tuberculosis, Meningeal
Adjunctive dexamethasone for the treatment of HIV-uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype (LAST ACT): Study protocol for a randomised double blind placebo controlled non-inferiority trial.
Clinical Parameters, Routine Inflammatory Markers, and LTA4H Genotype as Predictors of Mortality Among 608 Patients With Tuberculous Meningitis in Indonesia.
Evaluating the Impact of LTA4H Genotype and Immune Status on Survival From Tuberculous Meningitis.
Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis.
LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome.
Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in Eastern China.
Tuberculosis of the Central Nervous System.
Tuberculosis, Osteoarticular
Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in Eastern China.
Tuberculosis, Pleural
Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in Eastern China.
Tuberculosis, Pulmonary
Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects.
Gene polymorphisms in patients with pulmonary tuberculosis from Mozambique.
Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in Eastern China.