Information on EC 3.2.2.31 - adenine glycosylase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC3.2.2.31
Word Map on EC 3.2.2.31
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This record set is specific for:
Homo sapiens


The expected taxonomic range for this enzyme is: Bacteria, Eukaryota


The taxonomic range for the selected organisms is: Homo sapiens

EC NUMBER
COMMENTARY hide
3.2.2.31
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RECOMMENDED NAME
GeneOntology No.
adenine glycosylase
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SYSTEMATIC NAME
IUBMB Comments
adenine-DNA deoxyribohydrolase (adenine-releasing)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
show the reaction diagram
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-
-
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?
DNA containing a guanine:adenine mismatch + H2O
?
show the reaction diagram
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-
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?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
?
show the reaction diagram
-
-
-
-
?
DNA containing a guanine:adenine mismatch + H2O
?
show the reaction diagram
-
-
-
-
?
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
HiTrap heparin column chromatography
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli JM101, CC104 and GT100 cells
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G382D
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the mutant enzyme shows a reduced ability to recognize and repair 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatches
Y165C
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the mutant enzyme shows a reduced ability to recognize and repair 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatches