Reference on EC 3.2.2.21 - DNA-3-methyladenine glycosylase II
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Evensen, G.; Seeberg, E.
Adaptation to alkylation resistance involves the induction of a DNA glycosylase
Nature
296
773-775
1982
Escherichia coli
Karran, P.; Hjelmgren, T.; Lindahl, T.
Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents
Nature
296
770-773
1982
Escherichia coli, no activity in Escherichia coli
Thomas, L.; Yang, C.H.; Goldthwait, D.A.
Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine
Biochemistry
21
1162-1169
1982
Escherichia coli, Escherichia coli BW 9062
Clarke, N.D.; Kvaal, M.; Seeberg, E.
Cloning of Escherichia coli genes encoding 3-methyladenine DNA glycosylases I and II
Mol. Gen. Genet.
197
368-372
1984
Escherichia coli
Riazuddin, S.; Athar, A.; Ahmed, Z.; Lali, S.M.; Sohail, A.
DNA glycosylase enzymes induced during chemical adaptation of M. luteus
Nucleic Acids Res.
15
6607-6624
1987
Escherichia coli, Micrococcus luteus
Bjelland, S.; Seeberg, E.
Different efficiencies of the Tag and AlkA DNA glycosylases from Escherichia coli in the removal of 3-methyladenine from single-stranded DNA
FEBS Lett.
397
127-129
1996
Escherichia coli
Yamagata, Y.; Odawara, K.; Tomita, K.; Nakabeppu, Y.; Sekiguchi, M.
Crystallization and preliminary X-ray diffraction studies of 3-methyladenine-DNA glycosylase II from Escherichia coli
J. Mol. Biol.
204
1055-1056
1988
Escherichia coli
Bjelland, S.; Birkeland, N.K.; Benneche, T.; Volden, G.; Seeberg, E.
DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the AlkA enzyme in Escherichia coli
J. Biol. Chem.
269
30489-30495
1994
Escherichia coli
Schaerer, O.D.; Ortholand, J.Y.; Ganesan, A.; Ezaz-Nikpay, K.; Verdine, G.L.
Specific binding of the DNA repair enzyme AlkA to a pyrrolidine-based inhibitor
J. Am. Chem. Soc.
117
6623-6624
1995
Escherichia coli
-
Matijasevic, Z.; Stering, A.; Niu, T.Q.; Austin-Ritchie, P.; Ludlum, D.B.
Release of sulfur mustard-modified DNA bases by Escherichia coli 3-methyladenine DNA glycosylase II
Carcinogenesis
17
2249-2252
1996
Escherichia coli
Yamagata, Y.; Kato, M.; Odawara, K.; Tokuno, Y.; Nakashima, Y.; Matsushima, N.; Yasumura, K.; Tomita, K.; Ihara, K.; Fujii, Y.; Nakabeppu, Y.; Sekiguchi, M.; Fujii, S.
Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli
Cell
86
311-319
1996
Escherichia coli
Borys, E.; Kusmierek, J.T.
Endogenous and exogenous DNA lesions recognized by N-alkylpurine-DNA glycosylases
Acta Biochim. Pol.
45
579-586
1998
Escherichia coli, Escherichia coli JM105
Cerda, S.R.; Turk, P.W.; Thor, A.D.; Weitzman, S.A.
Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG) in breast cancer
FEBS Lett.
431
12-18
1998
Homo sapiens
Je, K.H.; Son, J.K.; O'Connor, T.R.; Lee, C.S.
Hepsulfam induced DNA adducts and its excision repair by bacterial and mammalian 3-methyladenine DNA glycosylases
Mol. Cells
8
691-697
1998
Escherichia coli, Homo sapiens, Rattus norvegicus
Kim, N.K.; Lee, S.H.; Cha, K.Y.; Seo, J.S.
Tissue-specific expression and activation of N-methylpurine-DNA glycosylase in thymic carcinomas of transgenic mice expressing the SV40 large T-antigen gene
Mol. Cells
8
383-387
1998
Mus musculus
Roy, R.; Biswas, T.; Hazra, T.K.; Roy, G.; Grabowski, D.T.; Izumi, T.; Srinivasan, G.; Mitra, S.
Specific interaction of wild-type and truncated mouse N-methylpurine-DNA glycosylase with ethenoadenine-containing DNA
Biochemistry
37
580-589
1998
Mus musculus
Masaoka, A.; Terato, H.; Kobayashi, M.; Honsho, A.; Ohyama, Y.; Ide, H.
Enzymatic repair of 5-formyluracil. I. Excision of 5-formyluracil site-specifically incorporated into oligonucleotide substrates by alka protein (Escherichia coli 3-methyladenine DNA glycosylase II)
J. Biol. Chem.
274
25136-25143
1999
Escherichia coli, Escherichia coli MV1161
Terato, H.; Masaoka, A.; Kobayashi, M.; Fukushima, S.; Ohyama, Y.; Yoshida, M.; Ide, H.
Enzymatic repair of 5-formyluracil. II. Mismatch formation between 5-formyluracil and guanine during dna replication and its recognition by two proteins involved in base excision repair (AlkA) and mismatch repair (MutS)
J. Biol. Chem.
274
25144-25150
1999
Escherichia coli, Escherichia coli AB1157
Wyatt, M.D.; Allan, J.M.; Lau, A.Y.; Ellenberger, T.E.; Samson, L.D.
3-Methyladenine DNA glycosylases: structure, function, and biological importance
Bioessays
21
668-676
1999
Arabidopsis thaliana, Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe
Hollis, T.; Ichikawa, Y.; Ellenberger, T.
DNA bending and a flip-out mechanism for base excision by the helix-hairpin-helix DNA glycosylase, Escherichia coli AlkA
EMBO J.
19
758-766
2000
Escherichia coli (P04395), Escherichia coli
Roy, R.; Biswas, T.; Lee, J.C.; Mitra, S.
Mutation of a unique aspartate residue abolishes the catalytic activity but not substrate binding of the mouse N-methylpurine-DNA glycosylase (MPG)
J. Biol. Chem.
275
4278-4282
2000
Homo sapiens, Mus musculus
Birkeland, N.K.; Anensen, H.; Knaevelsrud, I.; Kristoffersen, W.; Bjoras, M.; Robb, F.T.; Klungland, A.; Bjelland, S.
Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus
Biochemistry
41
12697-12705
2002
Archaeoglobus fulgidus, Escherichia coli
Biswas, T.; Clos, L.J.2nd.; SantaLucia, J.Jr.; Mitra, S.; Roy, R.
Binding of specific DNA base-pair mismatches by N-methylpurine-DNA glycosylase and its implication in initial damage recognition
J. Mol. Biol.
320
503-513
2002
Mus musculus
Saparbaev, M.; Langouet, S.; Privezentzev, C.V.; Guengerich, F.P.; Cai, H.; Elder, R.H.; Laval, J.
1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase
J. Biol. Chem.
277
26987-26993
2002
Homo sapiens
Teale, M.; Symersky, J.; DeLucas, L.
3-Methyladenine-DNA glycosylase II: the crystal structure of an AlkA-hypoxanthine complex suggests the possibility of product inhibition
Bioconjug. Chem.
13
403-407
2002
Escherichia coli
Terato, H.; Masaoka, A.; Asagoshi, K.; Honsho, A.; Ohyama, Y.; Suzuki, T.; Yamada, M.; Makino, K.; Yamamoto, K.; Ide, H.
Novel repair activities of AlkA (3-methyladenine DNA glycosylase II) and endonuclease VIII for xanthine and oxanine, guanine lesions induced by nitric oxide and nitrous acid
Nucleic Acids Res.
30
4975-4984
2002
Escherichia coli, Escherichia coli MV1161
Fishel, M.L.; Seo, Y.R.; Smith, M.L.; Kelley, M.R.
Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing
Cancer Res.
63
608-615
2003
Homo sapiens
Wozniak, K.; Blasiak, J.
Nickel impairs the repair of UV- and MNNG-damaged DNA
Cell. Mol. Biol. Lett.
9
83-94
2004
Homo sapiens
Connor, E.E.; Wilson, J.J.; Wyatt, M.D.
Effects of substrate specificity on initiating the base excision repair of N-methylpurines by variant human 3-methyladenine DNA glycosylases
Chem. Res. Toxicol.
18
87-94
2005
Homo sapiens
Guliaev, A.B.; Singer, B.; Hang, B.
Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts
DNA Repair
3
1311-1321
2004
Escherichia coli
O'Brien, P.J.; Ellenberger, T.
The Escherichia coli 3-methyladenine DNA glycosylase AlkA has a remarkably versatile active site
J. Biol. Chem.
279
26876-26884
2004
Escherichia coli
Alseth, I.; Rognes, T.; Lindback, T.; Solberg, I.; Robertsen, K.; Kristiansen, K.I.; Mainieri, D.; Lillehagen, L.; Kolsto, A.B.; Bjoras, M.
A new protein superfamily includes two novel 3-methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD
Mol. Microbiol.
59
1602-1609
2006
Bacillus cereus
Alseth, I.; Osman, F.; Korvald, H.; Tsaneva, I.; Whitby, M.C.; Seeberg, E.; Bjoras, M.
Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe
Nucleic Acids Res.
33
1123-1131
2005
Schizosaccharomyces pombe
Leiros, I.; Nabong, M.P.; Gr?svik, K.; Ringvoll, J.; Haugland, G.T.; Uldal, L.; Reite, K.; Olsbu, I.K.; Knaevelsrud, I.; Moe, E.; Andersen, O.A.; Birkeland, N.K.; Ruoff, P.; Klungland, A.; Bjelland, S.
Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA
EMBO J.
26
2206-2217
2007
Archaeoglobus fulgidus
Harrison, J.F.; Rinne, M.L.; Kelley, M.R.; Druzhyna, N.M.; Wilson, G.L.; Ledoux, S.P.
Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents
Glia
55
1416-1425
2007
Rattus norvegicus
Adhikari, S.; Toretsky, J.A.; Yuan, L.; Roy, R.
Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase
J. Biol. Chem.
281
29525-29532
2006
Mus musculus
Wang, P.; Guliaev, A.B.; Hang, B.
Metal inhibition of human N-methylpurine-DNA glycosylase activity in base excision repair
Toxicol. Lett.
166
237-247
2006
Homo sapiens (P29372), Homo sapiens
Rubinson, E.H.; Metz, A.H.; OQuin, J.; Eichman, B.F.
A new protein architecture for processing alkylation damaged DNA: the crystal structure of DNA glycosylase AlkD
J. Mol. Biol.
381
13-23
2008
Bacillus cereus
Adhikari, S.; Manthena, P.V.; Uren, A.; Roy, R.
Expression, purification and characterization of codon-optimized human N-methylpurine-DNA glycosylase from Escherichia coli
Protein Expr. Purif.
58
257-262
2008
Homo sapiens
Zhao, B.; OBrien, P.J.
Kinetic mechanism for the excision of hypoxanthine by Escherichia coli AlkA and evidence for binding to DNA ends
Biochemistry
50
4350-4359
2011
Escherichia coli
Bowman, B.R.; Lee, S.; Wang, S.; Verdine, G.L.
Structure of Escherichia coli AlkA in complex with undamaged DNA
J. Biol. Chem.
285
35783-35791
2010
Escherichia coli (P04395), Escherichia coli
Moe, E.; Hall, D.R.; Leiros, I.; Monsen, V.T.; Timmins, J.; McSweeney, S.
Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans
Acta Crystallogr. Sect. D
68
703-712
2012
Deinococcus radiodurans (Q9RRB0), Deinococcus radiodurans
Admiraal, S.; O'Brien, P.
DNA-N-glycosylases process novel O-glycosidic sites in DNA
Biochemistry
52
4066-4074
2013
Escherichia coli (P04395), Escherichia coli
Michelson, A.Z.; Chen, M.; Wang, K.; Lee, J.K.
Gas-phase studies of purine 3-methyladenine DNA glycosylase II (AlkA) substrates
J. Am. Chem. Soc.
134
9622-9633
2012
Escherichia coli (P04395)
Admiraal, S.J.; O'Brien, P.J.
Base excision repair enzymes protect abasic sites in duplex DNA from interstrand cross-links
Biochemistry
54
1849-1857
2015
Escherichia coli, Homo sapiens (P29372), Homo sapiens
Lenz, S.A.P.; Wetmore, S.D.
Evaluating the substrate selectivity of alkyladenine DNA glycosylase the synergistic interplay of active site flexibility and water reorganization
Biochemistry
55
798-808
2016
Homo sapiens (P29372), Homo sapiens
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