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Disease on EC 3.2.1.35 - hyaluronoglucosaminidase

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DISEASE
TITLE OF PUBLICATION
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Abortion, Spontaneous
Murine abortion is associated with enhanced hyaluronan expression and abnormal localization at the fetomaternal interface.
Achondroplasia
Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
Acquired Immunodeficiency Syndrome
Resuscitation of the newborn infant; a preliminary clinical report on the use of a detergent and a spreading factor as aids in pulmonary expansion.
Acute Coronary Syndrome
Platelet hyaluronidase 2 enrichment in acute coronary syndromes: a conceivable role in monocyte-platelet aggregate formation.
Adenocarcinoma
Global ph 3, randomized, double-blind, placebo-controlled study of PEGylated recombinant human hyaluronidase PH20 (PEGPH20) + nab-paclitaxel & gemcitabine in pts with previously untreated, hyaluronan-high, stage iv pancreatic ductal adenocarcinoma.
Identification of Hyal2 as the cell-surface receptor for jaagsiekte sheep retrovirus and ovine nasal adenocarcinoma virus.
Increased Expression of HYAL1 in Pancreatic Ductal Adenocarcinoma.
Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis.
[Combined action of alpha-chymotrypsin and testicular hyaluronidase on the take of the homotransplant of a spontaneous mammary adenocarcinoma in Swiss mice]
Adenocarcinoma of Lung
[Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer]
Adenocarcinoma, Bronchiolo-Alveolar
Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation.
Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus.
Adenoma, Oxyphilic
Molecular characterization of kidney cancer: Association of Hyaluronic Acid Family With Histological Subtypes and Metastasis.
Amblyopia
Effects of digesting chondroitin sulfate proteoglycans on plasticity in cat primary visual cortex.
Anaphylaxis
The anaphylactogenicity of testicular hyaluronidase and a species difference in testicular hyaluronidase demonstrated by isolated organ anaphylaxis.
Anemia, Hemolytic
Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy.
Angina, Stable
Platelet hyaluronidase 2 enrichment in acute coronary syndromes: a conceivable role in monocyte-platelet aggregate formation.
Angioedemas, Hereditary
Health-related quality of life with hereditary angioedema following prophylaxis with subcutaneous C1-inhibitor with recombinant hyaluronidase.
Arthritis
A complete deficiency of Hyaluronoglucosaminidase 1 (HYAL1) presenting as familial juvenile idiopathic arthritis.
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction.
Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan.
Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology.
Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice.
Sequential appearance of fibronectin and collagen fibres in experimental arthritis in rabbits.
Arthritis, Juvenile
A complete deficiency of Hyaluronoglucosaminidase 1 (HYAL1) presenting as familial juvenile idiopathic arthritis.
Arthritis, Rheumatoid
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction.
Astrocytoma
Hyaluronidase-2 overexpression accelerates intracerebral but not subcutaneous tumor formation of murine astrocytoma cells.
Mammalian-produced chondroitinase AC mitigates axon inhibition by chondroitin sulfate proteoglycans.
Brain Injuries
Chondroitinase enhances cortical map plasticity and increases functionally active sprouting axons after brain injury.
Brain Injuries, Traumatic
Chondroitinase enhances cortical map plasticity and increases functionally active sprouting axons after brain injury.
Brain Neoplasms
Role of HYAL1 expression in primary breast cancer in the formation of brain metastases.
Breast Neoplasms
Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer.
CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion.
Cell migration inducing hyaluronidase 1 (CEMIP) activates STAT3 pathway to facilitate cell proliferation and migration in breast cancer.
Expression of PH-20 in normal and neoplastic breast tissue.
Gene expression of O-GlcNAc cycling enzymes in human breast cancers.
HYAL1 overexpression is correlated with the malignant behavior of human breast cancer.
Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer.
Hyaluronidases: A Therapeutic Enzyme.
Isolation and characterization of a hyaluronidase from the venom of Chinese red scorpion Buthus martensi.
Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor ? in breast cancer cells.
Role of HYAL1 expression in primary breast cancer in the formation of brain metastases.
Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins.
Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells.
Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells.
Stimulation of haptotaxis and migration of tumor cells by serum spreading factor.
Subcutaneous administration of rituximab (MabThera) and trastuzumab (Herceptin) using hyaluronidase.
The Association Between Breast Cancer and Blood-Based Methylation of S100P and HYAL2 in the Chinese Population.
The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer.
Upregulation of HYAL1 Expression in Breast Cancer Promoted Tumor Cell Proliferation, Migration, Invasion and Angiogenesis.
[Effect of silencing of hyaluronidase gene HYAL1 by RNA interference on proliferation of human breast cancer cells]
Bursitis
In-Vivo Efficacy of Recombinant Human Hyaluronidase (rHuPH20) Injection for Accelerated Healing of Murine Retrocalcaneal Bursitis and Tendinopathy.
Carcinogenesis
Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation.
Global gene expression profile in canine mammary carcinomas.
Hyaluronidase 2 and its intriguing role as a cell-entry receptor for oncogenic sheep retroviruses.
Sheep retrovirus structural protein induces lung tumours.
Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing.
Carcinoma
Accelerated tumor development in interferon-treated B6.C-Hyal-1 a mice.
Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients.
Can recurrence and progression be predicted by HYAL-1 expression in primary T1 bladder cancer?
Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas.
Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.
Expression of Hyaluronan Synthases (HAS1-3) and Hyaluronidases (HYAL1-2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content.
HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro.
HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA.
Hyaluronan Synthase and Hyaluronidase Expression in Serous Ovarian Carcinoma is Related to Anatomic Site and Chemotherapy Exposure.
Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model.
Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis.
Spreading factor in human carcinomas.
The growth rate of two transplantable murine tumors, 3LL lung carcinoma and B16F10 melanoma, is influenced by Hyal-1, a locus determining hyaluronidase levels and polymorphism.
The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus.
The investigation of hyaluronic acid and hyaluronidase-1 levels as tumour marker in larynx cancer.
Carcinoma, Hepatocellular
Changes in the lectin binding capacities of hepatoma cells after treatment with chondroitinase.
Human spreading factor: synthesis and response by HepG2 hepatoma cells in culture.
Carcinoma, Intraductal, Noninfiltrating
Expression of PH-20 in normal and neoplastic breast tissue.
Carcinoma, Non-Small-Cell Lung
Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer.
[Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer]
Carcinoma, Ovarian Epithelial
Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer.
Carcinoma, Small Cell
Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis.
Carcinoma, Squamous Cell
Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma.
Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients.
HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro.
Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis.
The investigation of hyaluronic acid and hyaluronidase-1 levels as tumour marker in larynx cancer.
Chondrosarcoma
Specific binding of peanut agglutinin and soybean agglutinin to chondroitinase ABC-digested cartilage proteoglycans: histochemical, ultrastructural cytochemical, and biochemical characterization.
Colitis
Platelet hyaluronidase-2 regulates the early stages of inflammatory disease in colitis.
Colonic Neoplasms
Methylation status at HYAL2 predicts overall and progression-free survival of colon cancer patients under 5-FU chemotherapy.
The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer.
Colorectal Neoplasms
Hyaluronan Metabolism is Associated with DNA Repair Genes in Breast and Colorectal Cancer. Screening of Potential Progression Markers Using qPCR.
Hyaluronidases and their inhibitors in the serum of colorectal carcinoma patients.
The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer.
Connective Tissue Diseases
A nonsynonymous polymorphism (rs117179004, T392M) of hyaluronidase 1 (HYAL1) is associated with increased risk of idiopathic pulmonary fibrosis in Southern Han Chinese.
Cor Triatriatum
Hyaluronidase 2 deficiency is a molecular cause of cor triatriatum sinister in mice.
Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.
COVID-19
An epigenome-wide DNA methylation study of patients with COVID-19.
COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction.
Dehydration
Restricted Water Intake Adversely Affects Rat Vocal Fold Biology.
Diabetes Mellitus
Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians.
Improved postprandial glycemic control in patients with type 2 diabetes from subcutaneous injection of insulin lispro with hyaluronidase.
Diabetes Mellitus, Type 1
Hyaluronidase 1 Deficiency Preserves Endothelial Function and Glycocalyx Integrity in Early Streptozotocin-Induced Diabetes.
Diabetes Mellitus, Type 2
A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans.
Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians.
Improved postprandial glycemic control in patients with type 2 diabetes from subcutaneous injection of insulin lispro with hyaluronidase.
MGEA5-14 polymorphism and type 2 diabetes in Mexico City.
Diabetic Retinopathy
Hyaluronidase (Vitrase)--ISTA: hyaluronidase--ISTA pharmaceuticals.
Vitrase ISTA Pharmaceuticals.
Dupuytren Contracture
Biomechanical properties of normal tendons, normal palmar aponeuroses and palmar aponeuroses from patients with Dupuytren's disease subjected to elastase and chondroitinase treatment.
Biomechanical properties of normal tendons, normal palmar aponeuroses, and tissues from patients with Dupuytren's disease subjected to elastase and chondroitinase treatment.
Ehlers-Danlos Syndrome
Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
Empyema
[Effect of testicular hyaluronidase applied intrapleurally on development of antibodies in the treatment of chronic empyema.]
Endometrial Neoplasms
Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer.
Expression patterns of hyaluronan, hyaluronan synthases and hyaluronidases indicate a role for hyaluronan in the progression of endometrial cancer.
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma.
Endometriosis
The Hyaluronic Acid System is Intact in Menstrual Endometrial Cells in Women With and Without Endometriosis.
Epididymitis
Mechanism of infertility in male guinea pigs immunized with sperm PH-20.
Epiretinal Membrane
Enzymatic vitreous disruption.
Erythema
Safety, Tolerability, and Pharmacokinetics of High-Volume Subcutaneous Crenezumab, With and Without Recombinant Human Hyaluronidase in Healthy Volunteers.
Esophageal Squamous Cell Carcinoma
Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas.
Familial Primary Pulmonary Hypertension
Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension.
Fibrosarcoma
Chondroitin sulfate A regulates fibrosarcoma cell adhesion, motility and migration through JNK and tyrosine kinase signaling pathways.
Hyaluronidase induces murine L929 fibrosarcoma cells resistant to tumor necrosis factor and Fas cytotoxicity in the presence of actinomycin D.
Stimulation of haptotaxis and migration of tumor cells by serum spreading factor.
Gangliosidosis, GM1
Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
Gas Gangrene
Molecular genetic analysis of the nagH gene encoding a hyaluronidase of Clostridium perfringens.
Genetic Diseases, Inborn
Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism.
Glaucoma
Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration.
Glaucoma, Open-Angle
Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration.
Glioblastoma
Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity.
Glioma
Characterization of hyaluronan synthase from a human glioma cell line.
Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines.
Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity.
Heart Defects, Congenital
Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure.
Heart Failure
Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure.
Hemoperitoneum
[Action of the spreading factor (hyaluronidase) on the reabsorption of hemoperitoneum and hemarthros.]
Hemorrhagic Septicemia
Hyaluronidase and chondroitinase activity of Pasteurella multocida serotype B:2 involved in hemorrhagic septicaemia.
Herpes Zoster
A role for the migrating sperm surface antigen PH-20 in guinea pig sperm binding to the egg zona pellucida.
Antifertility effects of tetradecyl sodium sulphate in rabbits.
Binding of both acrosome-intact and acrosome-reacted guinea pig sperm to the zona pellucida during in vitro fertilization.
cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals.
Epididymosomes are involved in the acquisition of new sperm proteins during epididymal transit.
Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20.
Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass.
Location of the PH-20 protein on acrosome-intact and acrosome-reacted spermatozoa of cynomolgus macaques.
Mechanism of infertility in male guinea pigs immunized with sperm PH-20.
Migration of the guinea pig sperm membrane protein PH-20 from one localized surface domain to another does not occur by a simple diffusion-trapping mechanism.
Molecular cloning of the human and monkey sperm surface protein PH-20.
Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg.
PH-20 but not acrosin is involved in sperm penetration of the macaque zona pellucida.
Rearrangement of the PH-20 protein on the surface of macaque spermatozoa following exposure to anti-PH-20 antibodies or binding to zona pellucida.
Sperm exocytosis increases the amount of PH-20 antigen on the surface of guinea pig sperm.
Sperm surface protein PH-20 is bifunctional: one activity is a hyaluronidase and a second, distinct activity is required in secondary sperm-zona binding.
The dual functions of GPI-anchored PH-20: hyaluronidase and intracellular signaling.
Why did the sperm cross the cumulus? To get to the oocyte. Functions of the sperm surface proteins PH-20 and fertilin in arriving at, and fusing with, the egg.
hyaluronoglucosaminidase deficiency
A complete deficiency of Hyaluronoglucosaminidase 1 (HYAL1) presenting as familial juvenile idiopathic arthritis.
A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis.
Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism.
Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.
Cor Triatriatum sinister (Divided Left Atrium): histopathological features and clinical management.
Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy.
Endothelial Glycocalyx as a Shield Against Diabetic Vascular Complications: Involvement of Hyaluronan and Hyaluronidases.
Hyal-1 but not Hyal-3 deficiency has an impact on ovarian folliculogenesis and female fertility by altering the follistatin/activin/smad3 pathway and the apoptotic process.
Hyaluronidase 1 Deficiency Preserves Endothelial Function and Glycocalyx Integrity in Early Streptozotocin-Induced Diabetes.
Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure.
Hyaluronidase 2 deficiency is a molecular cause of cor triatriatum sinister in mice.
Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction.
Respective roles of hyaluronidases 1 and 2 in endogenous hyaluronan turnover.
Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?
hyaluronoglucuronidase deficiency
Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.
Hypersensitivity
Hyaluronidase: a review of approved formulations, indications and off-label use in chronic pain management.
Hypertension
Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension.
Idiopathic Pulmonary Fibrosis
A nonsynonymous polymorphism (rs117179004, T392M) of hyaluronidase 1 (HYAL1) is associated with increased risk of idiopathic pulmonary fibrosis in Southern Han Chinese.
HYAL1 Is Downregulated in Idiopathic Pulmonary Fibrosis and Inhibits HFL-1 Fibroblast Proliferation When Upregulated.
Immune System Diseases
Recombinant Human PH20: Baseline Analysis of the Reactive Antibody Prevalence in the General Population Using Healthy Subjects.
Infections
Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus.
Baculovirus Envelope Protein ODV-E66 Is a Novel Chondroitinase with Distinct Substrate Specificity.
Binding of Staphylococcus aureus by human serum spreading factor in an in vitro assay.
Cell-surface heparan sulfate proteoglycan mediates HIV-1 infection of T-cell lines.
Characterization of Edwardsiella tarda rpoN: roles in ?(70) family regulation, growth, stress adaption and virulence toward fish.
Insights into the virulence-related genes of Edwardsiella tarda isolated from turbot in Europe: genetic homogeneity and evidence for vibrioferrin production.
Recombinant human hyaluronidase-facilitated subcutaneous immunoglobulin infusion in primary immunodeficiency diseases.
Root Extracts From Ononis spinosa Inhibit IL-8 Release via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide.
STUDIES ON THE RELATIONSHIP OF THE SEX HORMONES TO INFECTION : I. THE EFFECT OF THE ESTROGENIC AND GONADOTROPIC HORMONES ON VACCINIA AND THE SPREADING FACTOR.
SYNERGISTIC ACTION OF HEMOPHILUS INFLUENZAE SUIS AND THE SWINE INFLUENZA VIRUS ON THE CHICK EMBRYO. II.
The FasX Small Regulatory RNA Negatively Regulates the Expression of Two Fibronectin-Binding Proteins in Group A Streptococcus.
The U3 and Env Proteins of Jaagsiekte Sheep Retrovirus and Enzootic Nasal Tumor Virus Both Contribute to Tissue Tropism.
[Effects of spreading factor on the infection titer of Lansing type poliomyelitis virus.]
[Significance of spreading factor in the phenomenon of infection and immunity.]
Infertility
Mechanism of infertility in male guinea pigs immunized with sperm PH-20.
Reversible contraceptive effect of PH-20 immunization in male guinea pigs.
Infertility, Male
SPAM1/HYAL5 double deficiency in male mice leads to severe male subfertility caused by a cumulus-oocyte complex penetration defect.
[A histochemical study on the testes from patients with idiopathic male infertility: identification of acidic glycoconjugates in the seminiferous tubular walls]
Inflammatory Bowel Diseases
Platelet hyaluronidase-2 regulates the early stages of inflammatory disease in colitis.
Intervertebral Disc Displacement
Recent advances in the therapeutic uses of chondroitinase ABC.
Treatment of chronic low back pain - new approaches on the horizon.
[Treatment of lumbar intervertebral disc displacement with chondroitinase ABC--experimental basis for clinical application]
Keloid
Biochemical and dynamic studies of collagen from human normal skin and keloid tissue.
Chondroitinase injection improves keloid pathology by reorganizing the extracellular matrix with regenerated elastic fibers.
The exzymatic determination of acidic glycosaminoglycans in scar and keloid wtih chondroitinase.
Keratoconus
Protective Effects of Soluble Collagen during Ultraviolet-A Crosslinking on Enzyme-Mediated Corneal Ectatic Models.
Proteoglycan molecules in keratoconus corneas.
Laryngeal Neoplasms
Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors.
Gene and protein expression of O-GlcNAc-cycling enzymes in human laryngeal cancer.
PH20: a novel tumor marker for laryngeal cancer.
The investigation of hyaluronic acid and hyaluronidase-1 levels as tumour marker in larynx cancer.
Leprosy
[Effect of testicular hyaluronidase on the development of murine leprosy.]
Liver Cirrhosis
Changes in the catalytic activities of proteoglycan-degrading lysosomal enzymes in parenchymal and non-parenchymal liver cells and in serum during the development of experimental liver fibrosis.
Lung Diseases, Interstitial
A nonsynonymous polymorphism (rs117179004, T392M) of hyaluronidase 1 (HYAL1) is associated with increased risk of idiopathic pulmonary fibrosis in Southern Han Chinese.
Lung Neoplasms
Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo.
Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer.
Hyaluronidase 2 and its intriguing role as a cell-entry receptor for oncogenic sheep retroviruses.
Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus.
Identification of Hyal2 as the cell-surface receptor for jaagsiekte sheep retrovirus and ovine nasal adenocarcinoma virus.
Role of the extracellular matrix in variations of invasive pathways in lung cancers.
[Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer]
Lymphatic Metastasis
Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients.
Gene expression of O-GlcNAc cycling enzymes in human breast cancers.
Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing.
The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer.
Lymphedema
A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.
Lymphoma
Expression of HYAL2 mRNA, hyaluronan and hyaluronidase in B-cell non-Hodgkin lymphoma: relationship with tumor aggressiveness.
Lymphoma, Follicular
Subcutaneous administration of rituximab (MabThera) and trastuzumab (Herceptin) using hyaluronidase.
Lymphoma, Non-Hodgkin
Expression of HYAL2 mRNA, hyaluronan and hyaluronidase in B-cell non-Hodgkin lymphoma: relationship with tumor aggressiveness.
Macular Degeneration
Altered Protein Function Caused by AMD-associated Variant rs704 Links Vitronectin to Disease Pathology.
Melanoma
A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion.
A synthetic peptide from the heparin-binding domain III (repeats III4-5) of fibronectin promotes stress-fibre and focal-adhesion formation in melanoma cells.
Accelerated tumor development in interferon-treated B6.C-Hyal-1 a mice.
Altered expression of versican and hyaluronan in melanocytic tumors of dogs.
Anti-tumor activities of chondroitinase AC and chondroitinase B: inhibition of angiogenesis, proliferation and invasion.
Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.
Stimulation of haptotaxis and migration of tumor cells by serum spreading factor.
The growth rate of two transplantable murine tumors, 3LL lung carcinoma and B16F10 melanoma, is influenced by Hyal-1, a locus determining hyaluronidase levels and polymorphism.
Meningioma
Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase.
Novel immunogenic antigen homologous to hyaluronidase in meningioma.
Mucopolysaccharidoses
A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis.
Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation.
Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX.
Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?
Mucopolysaccharidosis IV
Serum hyaluronidase aberrations in metabolic and morphogenetic disorders.
Myocardial Infarction
Glycosaminoglycan metabolism following acute myocardial infarction and the effects of intravenous hyaluronidase therapy.
Heparin inhibits bovine testicular hyaluronidase activity in myocardium of dogs with coronary artery occlusion.
The serum kinetics of bovine testicular hyaluronidase in dogs, rats and humans.
Myocardial Ischemia
Hyaluronidase reversal of increased coronary vascular resistance in ischemic rat hearts.
Neoplasm Metastasis
Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients.
Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis.
Expression of PH-20 in normal and neoplastic breast tissue.
Gene and protein expression of O-GlcNAc-cycling enzymes in human laryngeal cancer.
Gene expression of O-GlcNAc cycling enzymes in human breast cancers.
Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling.
Hyaluronan Synthase and Hyaluronidase Expression in Serous Ovarian Carcinoma is Related to Anatomic Site and Chemotherapy Exposure.
Hyaluronic acid family in bladder cancer: potential prognostic biomarkers and therapeutic targets.
Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer.
Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid.
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis.
Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling.
Role of HYAL1 expression in primary breast cancer in the formation of brain metastases.
S100P and HYAL2 as prognostic markers for patients with triple-negative breast cancer.
Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing.
Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer.
Targeting hyaluronic acid family for cancer chemoprevention and therapy.
Targeting hyaluronidase for cancer therapy: antitumor activity of sulfated hyaluronic acid in prostate cancer cells.
The role of spreading factor (hyaluronidase) in metastasis.
The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer.
Neoplasms
A Novel Four-Gene Signature Associated With Immune Checkpoint for Predicting Prognosis in Lower-Grade Glioma.
A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Bladder Cancer Patients.
Accelerated tumor development in interferon-treated B6.C-Hyal-1 a mice.
Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus.
Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients.
Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer.
Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis.
Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors.
Breaching the Castle Walls: Hyaluronan Depletion as a Therapeutic Approach to Cancer Therapy.
Cancer-associated splicing variants of the CDCA1 and MSMB genes expressed in cancer cell lines and surgically resected gastric cancer tissues.
Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation.
CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion.
Chondroitinase: A promising therapeutic enzyme.
Co-sedimentation of chondroitin sulfate A glycosaminoglycans and proteoglycans with the cytolytic secretory granules of rat large granular lymphocyte (LGL) tumor cells, and identification of a mRNA in normal and transformed LGL that encodes proteoglycans.
Concurrent expression of hyaluronan biosynthetic and processing enzymes promotes growth and vascularization of prostate tumors in mice.
Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor.
Cytologic and Histologic Features of Pleomorphic Undifferentiated Sarcoma Arising in a Hybrid Hemosiderotic Fibrolipomatous Tumor and Pleomorphic Hyalinizing Angiectatic Tumor: Report of an Unusual Case with a Literature Review.
Differentiation of Intracellular Hyaluronidase Isoform by Degradable Nanoassembly Coupled with RNA-Binding Fluorescence Amplification.
Elevated tissue expression of hyaluronic acid and hyaluronidase validates the HA-HAase urine test for bladder cancer.
Elevation of hyaluronidase-1 and soluble intercellular adhesion molecule-1 helps select bladder cancer patients at risk of invasion.
Enzootic nasal tumor virus envelope requires a very acidic pH for fusion activation and infection.
Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models.
Epigenetic Regulation of HYAL-1 Hyaluronidase Expression: IDENTIFICATION OF HYAL-1 PROMOTER.
Evaluation of the prognostic potential of hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer.
Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines.
Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas.
Expression of HYAL2 mRNA, hyaluronan and hyaluronidase in B-cell non-Hodgkin lymphoma: relationship with tumor aggressiveness.
Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.
Expression of Hyaluronan Synthases (HAS1-3) and Hyaluronidases (HYAL1-2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content.
Expression of PH-20 in normal and neoplastic breast tissue.
Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo.
Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors.
Expression patterns of hyaluronan, hyaluronan synthases and hyaluronidases indicate a role for hyaluronan in the progression of endometrial cancer.
Gene and protein expression of O-GlcNAc-cycling enzymes in human laryngeal cancer.
Gene expression of O-GlcNAc cycling enzymes in human breast cancers.
Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer.
Global gene expression profile in canine mammary carcinomas.
Hemosiderotic Fibrolipomatous Tumor, Pleomorphic Hyalinizing Angiectatic Tumor, and Myxoinflammatory Fibroblastic Sarcoma: Related or Not?
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.
High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b.
Histochemical characterization of mucosubstances in bone and soft tissue-tumors.
Humanized chondroitinase ABC sensitizes glioblastoma cells to temozolomide.
HYAL-1 Hyaluronidase: A Potential Prognostic Indicator for Progression to Muscle Invasion and Recurrence in Bladder Cancer.
HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro.
HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor.
HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion.
HYAL1 overexpression is correlated with the malignant behavior of human breast cancer.
HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer.
HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA.
Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase.
Hyal2--less active, but more versatile?
Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed.
Hyaluronan and hyaluronidase in genitourinary tumors.
Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling.
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma.
Hyaluronic acid and HYAL-1 in prostate biopsy specimens: predictors of biochemical recurrence.
Hyaluronic acid modified mesoporous carbon nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells.
Hyaluronidase 2 and its intriguing role as a cell-entry receptor for oncogenic sheep retroviruses.
Hyaluronidase activity of human Hyal1 requires active site acidic and tyrosine residues.
Hyaluronidase and CD44 hyaluronan receptor expression in squamous cell laryngeal carcinoma.
Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model.
Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer.
Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking.
Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid.
Hyaluronidase-2 overexpression accelerates intracerebral but not subcutaneous tumor formation of murine astrocytoma cells.
Hyaluronidase-induced periodic modulation of the interstitial fluid pressure increases selective antibody uptake in human osteosarcoma xenografts.
Hyaluronidases and their inhibitors in the serum of colorectal carcinoma patients.
Hyaluronidases: A Therapeutic Enzyme.
Identification of Hyal2 as the cell-surface receptor for jaagsiekte sheep retrovirus and ovine nasal adenocarcinoma virus.
IgE-mediated allergic reaction to hyaluronidase in paediatric oncological patients.
Immunohistochemical evaluation of versican, in relation to chondroitin sulphate, in canine mammary tumours.
Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans in tumour tissues.
Improved enzootic nasal tumor virus pseudotype packaging cell lines reveal virus entry requirements in addition to the primary receptor Hyal2.
Improving the oral delivery efficiency of anticancer drugs by chitosan coated polycaprolactone-grafted hyaluronic acid nanoparticles.
Increased Expression of HYAL1 in Pancreatic Ductal Adenocarcinoma.
Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis.
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis.
Integrative functional genetic-epigenetic approach for selecting genes as urine biomarkers for bladder cancer diagnosis.
Involvement of hyaluronidases in colorectal cancer.
Laminin induces formation of neurite-like processes and potentiates prolactin secretion by GH3 rat pituitary cells.
Malignant tumor and spreading factor [Japanese text.]
Mechanism of cell entry and transformation by enzootic nasal tumor virus.
Molecular characterization of kidney cancer: Association of Hyaluronic Acid Family With Histological Subtypes and Metastasis.
Molecular risk assessment for breast cancer development in patients with ductal hyperplasias.
Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis.
Noncovalently Caged Firefly Luciferins Enable Amplifiable Bioluminescence Sensing of Hyaluronidase-1 Activity in Vivo.
Peptide fragments of laminin and fibronectin promote migration (haptotaxis and chemotaxis) of metastatic cells.
PH20: a novel tumor marker for laryngeal cancer.
Pharmacokinetics and tissue distribution of bovine testicular hyaluronidase and vinblastine in mice: an attempt to optimize the mode of adjuvant hyaluronidase administration in cancer chemotherapy.
Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.
Plasma hyaluronidase (Hyal-1) promotes tumor cell cycling.
Pleomorphic hyalinizing angiectatic tumor revisited: all tumors manifest typical morphologic features of myxoinflammatory fibroblastic sarcoma, further suggesting 2 morphologic variants of a single entity.
Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling.
Recent advances in the therapeutic uses of chondroitinase ABC.
Recombinant human hyaluronidase Hyal-1: insect cells versus Escherichia coli as expression system and identification of low molecular weight inhibitors.
Regulation of hyaluronidase activity by alternative mRNA splicing.
Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors.
Role of HYAL1 expression in primary breast cancer in the formation of brain metastases.
Role of the extracellular matrix in variations of invasive pathways in lung cancers.
Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins.
Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy.
SNP array and FISH findings in two pleomorphic hyalinizing angiectatic tumors.
Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing.
Stimulation of haptotaxis and migration of tumor cells by serum spreading factor.
Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment.
Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer.
Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis.
Targeted RNA-sequencing identifies FBXW4 instead of MGEA5 as fusion partner of TGFBR3 in pleomorphic hyalinizing angiectatic tumor.
Targeting hyaluronic acid family for cancer chemoprevention and therapy.
Targeting hyaluronidase for cancer therapy: antitumor activity of sulfated hyaluronic acid in prostate cancer cells.
TGFBR3 and MGEA5 rearrangements are much more common in "hybrid" hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas: a morphological and fluorescence in situ hybridization study.
TGFBR3 and MGEA5 Rearrangements in Pleomorphic Hyalinizing Angiectatic Tumors and the Spectrum of Related Neoplasms.
The growth rate of two transplantable murine tumors, 3LL lung carcinoma and B16F10 melanoma, is influenced by Hyal-1, a locus determining hyaluronidase levels and polymorphism.
The human endogenous retrovirus K(HML-2) has a broad envelope-mediated cellular tropism and is prone to inhibition at a post-entry, pre-integration step.
The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus.
The investigation of hyaluronic acid and hyaluronidase-1 levels as tumour marker in larynx cancer.
The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer.
The U3 and Env Proteins of Jaagsiekte Sheep Retrovirus and Enzootic Nasal Tumor Virus Both Contribute to Tissue Tropism.
Therapeutic Zfra4-10 or WWOX7-21 Peptide Induces Complex Formation of WWOX with Selective Protein Targets in Organs that Leads to Cancer Suppression and Spleen Cytotoxic Memory Z Cell Activation In Vivo.
Transformation of rodent fibroblasts by the jaagsiekte sheep retrovirus envelope is receptor independent and does not require the surface domain.
Transforming growth factor-beta protection of cancer cells against tumor necrosis factor cytotoxicity is counteracted by hyaluronidase (review).
Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts.
Two novel functions of hyaluronidase-2 (Hyal2): Formation of the glycocalyx and control of CD44-ERM interactions.
Upregulation of HYAL1 Expression in Breast Cancer Promoted Tumor Cell Proliferation, Migration, Invasion and Angiogenesis.
WW Domain-Containing Proteins YAP and TAZ in the Hippo Pathway as Key Regulators in Stemness Maintenance, Tissue Homeostasis, and Tumorigenesis.
WWOX Possesses N-Terminal Cell Surface-Exposed Epitopes WWOX7-21 and WWOX7-11 for Signaling Cancer Growth Suppression and Prevention In Vivo.
[Histochemical studies of bladder tumors]
[Studies on charge heterogeneity of arylsulfatase A from human lung cancer]
Neuroblastoma
A cell-surface heparan sulfate proteoglycan mediates neural cell adhesion and spreading on a defined sequence from the C-terminal cell and heparin binding domain of fibronectin, FN-C/H II.
Neurologic Manifestations
Effects of chondroitinase ABC on intrathecal and peripheral nerve tissue. An in vivo experimental study on rabbits.
Orchitis
Development of antifertility vaccine using sperm specific proteins.
Orthomyxoviridae Infections
Spreading Factor in Swine Influenza.
Osteoarthritis
A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis.
Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model.
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction.
Hyaluronic acid alkyl derivative: A novel inhibitor of metalloproteases and hyaluronidases.
Molecular NMR T2 values can predict cartilage stress-relaxation parameters.
Osteosarcoma
Hyaluronidase reduces the interstitial fluid pressure in solid tumours in a non-linear concentration-dependent manner.
Ovarian Neoplasms
Expression of Hyaluronan Synthases (HAS1-3) and Hyaluronidases (HYAL1-2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content.
Pancreatic Fistula
HYAL-1-induced autophagy facilitates pancreatic fistula for patients who underwent pancreaticoduodenectomy.
Pancreatic Neoplasms
HALO-109-301: a Phase III trial of PEGPH20 (with gemcitabine and nab-paclitaxel) in hyaluronic acid-high stage IV pancreatic cancer.
Parkinson Disease
Recent advances in the therapeutic uses of chondroitinase ABC.
Periodontal Pocket
Phenotypic evaluation of the effect of anaerobiosis on some virulence attributes of Candida albicans.
Peripheral Nerve Injuries
Recent advances in the therapeutic uses of chondroitinase ABC.
Peritoneal Fibrosis
Multimeric vitronectin in ascites is involved in fibroblast spreading of EPS in patients on CAPD therapy.
Pheochromocytoma
Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A.
Plague
[On the problem of the relation of the plague microbe to hyaluronic acid and of the presence of the spreading factor in the microbe.]
Pleural Effusion
Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis.
Poliomyelitis
[Effects of spreading factor on the infection titer of Lansing type poliomyelitis virus.]
Prostatic Neoplasms
A Facile Approach to Functionalize Cell Membrane-Coated Nanoparticles.
Concurrent expression of hyaluronan biosynthetic and processing enzymes promotes growth and vascularization of prostate tumors in mice.
Epigenetic Regulation of HYAL-1 Hyaluronidase Expression: IDENTIFICATION OF HYAL-1 PROMOTER.
HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor.
Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model.
Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer.
Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis.
Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling.
Regulation of hyaluronidase activity by alternative mRNA splicing.
Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing.
Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer.
Pulmonary Adenomatosis, Ovine
Ability of hyaluronidase 2 to degrade extracellular hyaluronan is not required for its function as a receptor for jaagsiekte sheep retrovirus.
Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus.
Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation.
Correction for Vigdorovich et al., Expression and Characterization of a Soluble, Active Form of the Jaagsiekte Sheep Retrovirus Receptor, Hyal2.
Enzootic nasal tumor virus envelope requires a very acidic pH for fusion activation and infection.
Expression and characterization of a soluble, active form of the jaagsiekte sheep retrovirus receptor, Hyal2.
Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus.
Identification of Hyal2 as the cell-surface receptor for jaagsiekte sheep retrovirus and ovine nasal adenocarcinoma virus.
The human endogenous retrovirus K(HML-2) has a broad envelope-mediated cellular tropism and is prone to inhibition at a post-entry, pre-integration step.
The U3 and Env Proteins of Jaagsiekte Sheep Retrovirus and Enzootic Nasal Tumor Virus Both Contribute to Tissue Tropism.
Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2.
Pulmonary Disease, Chronic Obstructive
Alterations in plasma hyaluronic acid in patients with clinically stable COPD versus (non)smoking controls.
Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation.
Serum levels of hyaluronic acid are associated with COPD severity and predict survival.
Pulmonary Edema
[Favorable effect of estrogenic hormone on acute pulmonary edema; interpretation of the effect of hyaluronic action and studies on the effect of testicular hyaluronidase on experimental acute pulmonary edema induced with epinephrine.]
Rhabdomyosarcoma
Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells.
Rheumatic Diseases
[Biological study of five cases of acute articular rheumatism treated with corticotrophin and cortisone; evaluation of the urinary corticoids and of the skin spreading factor.]
[Testicular hyaluronidase in therapy of rheumatism.]
Rheumatic Fever
Relation of the hemolytic streptococcus to rheumatic fever; effect of streptococcic spreading factor in rheumatic patients and others.
[Biological study of five cases of acute articular rheumatism treated with corticotrophin and cortisone; evaluation of the urinary corticoids and of the skin spreading factor.]
Rheumatoid Nodule
Rheumatoid nodules. A lightmicroscopical study with special reference to fibrin and fibronectin.
Sarcoma
Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor.
Hemosiderotic Fibrolipomatous Tumor, Pleomorphic Hyalinizing Angiectatic Tumor, and Myxoinflammatory Fibroblastic Sarcoma: Related or Not?
Pleomorphic hyalinizing angiectatic tumor revisited: all tumors manifest typical morphologic features of myxoinflammatory fibroblastic sarcoma, further suggesting 2 morphologic variants of a single entity.
SNP array and FISH findings in two pleomorphic hyalinizing angiectatic tumors.
TGFBR3 and MGEA5 rearrangements are much more common in "hybrid" hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas: a morphological and fluorescence in situ hybridization study.
TGFBR3 and MGEA5 Rearrangements in Pleomorphic Hyalinizing Angiectatic Tumors and the Spectrum of Related Neoplasms.
Sarcoma, Yoshida
The spreading factor in Yoshida sarcoma.
Spinal Cord Injuries
Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system.
Chondroitin sulfate proteoglycans in spinal cord contusion injury and the effects of chondroitinase treatment.
Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury.
Chondroitinase ABC Enhances Pericontusion Axonal Sprouting But Does Not Confer Robust Improvements in Behavioral Recovery.
Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord.
Chondroitinase administration and pcDNA3.1-BDNF-BMSC transplantation promote motor functional recovery associated with NGF expression in spinal cord-transected rat.
Chondroitinase and growth factors enhance activation and oligodendrocyte differentiation of endogenous neural precursor cells after spinal cord injury.
Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury.
Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury.
Chondroitinase: A promising therapeutic enzyme.
Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury.
Combining Constitutively Active Rheb Expression and Chondroitinase Promotes Functional Axonal Regeneration after Cervical Spinal Cord Injury.
Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury.
Exogenous BDNF enhances the integration of chronically injured axons that regenerate through a peripheral nerve grafted into a chondroitinase-treated spinal cord injury site.
Guiding migration of transplanted glial progenitor cells in the injured spinal cord.
Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.
Injured mice at the gym: Review, results and considerations for combining chondroitinase and locomotor exercise to enhance recovery after spinal cord injury.
Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury.
Magnetite nanoparticle as a support for stabilization of chondroitinase ABCI.
Modification of N-glycosylation sites allows secretion of bacterial chondroitinase ABC from mammalian cells.
Molecular control of brain plasticity and repair.
Nerve regeneration restores supraspinal control of bladder function after complete spinal cord injury.
Operation spinal cord regeneration: Patterning information residing in extracellular matrix glycosaminoglycans.
Partial functional recovery after complete spinal cord transection by combined chondroitinase and clenbuterol treatment.
Porous silicon nanoparticle as a stabilizing support for chondroitinase.
Recent advances in the therapeutic uses of chondroitinase ABC.
Scar-busting chondroitinase with peripheral nerve grafting promotes axonal regeneration in chronic spinal cord injury.
Single, high-dose intraspinal injection of chondroitinase reduces glycosaminoglycans in injured spinal cord and promotes corticospinal axonal regrowth after hemisection but not contusion.
The yellow fluorescent protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injury.
Therapeutic Effect of Cell Transplantation and Chondroitinase in Rat Spinal Cord Injury.
tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2.
Transplantation and repair: Combined cell implantation and chondroitinase delivery prevents deterioration of bladder function in rats with complete spinal cord injury.
Spondylitis, Ankylosing
Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology.
Squamous Cell Carcinoma of Head and Neck
Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors.
Stomach Neoplasms
Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer.
MiR-148a-3p targets CEMIP to suppress the genesis of gastric cancer cells.
Stroke
Enhancing Spinal Plasticity Amplifies the Benefits of Rehabilitative Training and Improves Recovery from Stroke.
Hyaluronan expression following middle cerebral artery occlusion in the rat.
Recent advances in the therapeutic uses of chondroitinase ABC.
Syphilis
Speculations on the role of spreading factor (hyaluronidase) in experimental and human syphilis.
Tendinopathy
Active hyaluronidase 2 expression in the granulation tissue formed in the healing process of equine superficial digital flexor tendonitis.
In-Vivo Efficacy of Recombinant Human Hyaluronidase (rHuPH20) Injection for Accelerated Healing of Murine Retrocalcaneal Bursitis and Tendinopathy.
Thrombocytopenia
Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis.
Thrombotic Microangiopathies
Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy.
Triple Negative Breast Neoplasms
High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b.
S100P and HYAL2 as prognostic markers for patients with triple-negative breast cancer.
Tuberculosis
[Diagnosis of tuberculosis by a rapid biologic method with testicular hyaluronidase.]
[Effect of removal of vaccinal focus on tuberculin sensitivity in guinea pigs vaccinated against tuberculosis with Petragnani anatuberculin with and without spreading factor.]
[Resistance induced by tuberculosis vaccination by killed Koch bacilli with (V.D.S.) or without addition of spreading factor; comparison with BCG.]
[SIGNIFICANCE OF THE SPREADING FACTOR IN THE PATHOGENESIS OF EXPERIMENTAL CUTANEOUS TUBERCULOSIS.]
Urinary Bladder Neoplasms
A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Bladder Cancer Patients.
Editorial Comment on: HYAL-1 Hyaluronidase: A Potential Prognostic Indicator for Progression to Muscle Invasion and Recurrence in Bladder Cancer.
Elevated tissue expression of hyaluronic acid and hyaluronidase validates the HA-HAase urine test for bladder cancer.
Elevation of hyaluronidase-1 and soluble intercellular adhesion molecule-1 helps select bladder cancer patients at risk of invasion.
Expression of HYAL1 and survivin RNA as diagnostic molecular markers for bladder cancer.
HYAL-1 Hyaluronidase: A Potential Prognostic Indicator for Progression to Muscle Invasion and Recurrence in Bladder Cancer.
HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor.
HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion.
HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer.
Hyal2 expression in tumor-associated myeloid cells mediates cancer-related inflammation in bladder cancer.
HYAL4-V1/Chondroitinase (Chase) Drives Gemcitabine Resistance and Predicts Chemotherapy Failure in Patients with Bladder Cancer.
Identification of bladder tumor-derived hyaluronidase: its similarity to HYAL1.
Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level.
Regulation of hyaluronidase activity by alternative mRNA splicing.
Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis.
Urinary Tract Infections
Root Extracts From Ononis spinosa Inhibit IL-8 Release via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide.
Vaccinia
On the influence of the spreading factor to the potency of the vaccinia virus.
STUDIES ON THE RELATIONSHIP OF THE SEX HORMONES TO INFECTION : I. THE EFFECT OF THE ESTROGENIC AND GONADOTROPIC HORMONES ON VACCINIA AND THE SPREADING FACTOR.
Virus Diseases
Ability of hyaluronidase 2 to degrade extracellular hyaluronan is not required for its function as a receptor for jaagsiekte sheep retrovirus.
Vitreoretinopathy, Proliferative
Vitronectin and proliferative intraocular disorders. I. A colocalisation study of the serum spreading factor, vitronectin, and fibronectin in traction membranes from patients with proliferative vitreoretinopathy.
Vitreous Hemorrhage
Hyaluronidase (Vitrase)--ISTA: hyaluronidase--ISTA pharmaceuticals.
Predicting response of vitreous hemorrhage after intravitreous injection of highly purified ovine hyaluronidase (Vitrase) in patients with diabetes.
Vitrase ISTA Pharmaceuticals.