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Information on EC 3.2.1.193 - ginsenosidase type I

for references in articles please use BRENDA:EC3.2.1.193

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IUBMB Comments

Ginsenosidase type I is slightly activated by Mg2+ or Ca2+ . The enzyme hydrolyses the 3-O-β-D-(1→2)-glucosidic bond, the 3-O-β-D-glucopyranosyl bond and the 20-O-β-D-(1→6)-glycosidic bond of protopanaxadiol-type ginsenosides. It usually leaves a single glucosyl residue attached at position 20 and one or no glucosyl residues at position 3. Starting with a ginsenoside that is glycosylated at both positions (e.g. ginsenoside Rb1, Rb2, Rb3, Rc or Rd), the most common products are ginsenoside F2 and ginsenoside C-K, with low amounts of ginsenoside Rh2.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
bglpm, ginsenoside-hydrolyzing beta-glucosidase, ginsenosidase type-i, ginsenosidase type i, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a protopanaxadiol-type ginsenoside with one glucosyl residue at position 3 + H2O = a protopanaxadiol-type ginsenoside with no glycosidic modifications at position 3 + D-glucopyranose
show the reaction diagram
(2)
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a protopanaxadiol-type ginsenoside with two glucosyl residues at position 3 + H2O = a protopanaxadiol-type ginsenoside with one glucosyl residue at position 3 + D-glucopyranose
show the reaction diagram
a protopanaxadiol-type ginsenoside with two glycosyl residues at position 20 + H2O = a protopanaxadiol-type ginsenoside with a single glucosyl residue at position 20 + a monosaccharide
show the reaction diagram
(3)
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PATHWAY SOURCE
PATHWAYS
MetaCyc
ginsenoside degradation I, ginsenoside degradation III
Highest Expressing Human Cell Lines
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