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IUBMB CommentsActs on both stereoisomers of the substrate and also, more slowly, on 3',5'-cyclic AMP and on 2',3'-cyclic AMP.
The enzyme appears in viruses and cellular organisms
Synonyms
phosphodiesterase, glycerol cyclic 1,2-phosphate 2-, rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase,
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phosphodiesterase, glycerol cyclic 1,2-phosphate 2-
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rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase
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glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate
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hydrolysis of phosphoric ester
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rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase
Acts on both stereoisomers of the substrate and also, more slowly, on 3',5'-cyclic AMP and on 2',3'-cyclic AMP.
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2',3'-cyclic AMP + H2O
3'-AMP + 2'-AMP
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69-72% 3'-AMP and 28-31% 2'-AMP
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3',5'-cyclic AMP + H2O
5'-AMP
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3',5'-cyclic GMP + H2O
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very low activity
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bis-(4-nitrophenyl) phosphate + H2O
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very low activity
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butyrylglycerol cyclic phosphate + H2O
butyrylglycerol phosphate
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glycerol 1,2-cyclic phosphate + H2O
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catabolism of phosphatidylcholine and phosphatidylethanolamine
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glycerol 1,2-cyclic phosphate + H2O
glycerol phosphate
glycerol 1,2-cyclic phosphate + H2O
glycerol phosphate
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racemic substrate
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glycerol 1,2-cyclic phosphate + H2O
glycerol phosphate
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racemic substrate
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glycerol 1,2-cyclic phosphate + H2O
glycerol phosphate
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racemic substrate
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glycerol 1,2-cyclic phosphate + H2O
glycerol phosphate
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glycerol 1,2-cyclic phosphate + H2O
glycerol phosphate
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racemic substrate
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glycerol 1,2-cyclic phosphate + H2O
glycerol phosphate
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racemic substrate
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glycerol 1,2-cyclic phosphate + H2O
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catabolism of phosphatidylcholine and phosphatidylethanolamine
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additional information
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no requirement for Ca2+ and Mg2+
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2'-AMP
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9 mM, 75% inhibition
2-naphthyl phosphate
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0.45 mM, 64% inhibition
3'-AMP
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9 mM, 68% inhibition
4-nitrophenyl phosphate
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5.5 mM, 90% inhibition
5'-AMP
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9 mM, 76% inhibition
ATP
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9 mM, 68% inhibition
cetyl phosphate
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0.45 mM, 29% inhibition
dibutyryl glycerol phosphate
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0.45 mM, 40% inhibition
ethyl phosphate
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0.25 mM, 34% inhibition
glycerol 1-phosphate
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5 mM, 16% inhibition
methyl phosphate
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0.25 mM, 34% inhibition
Phenyl phosphate
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0.45 mM, 68% inhibition
phosphatidic acid
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0.45 mM, 43% inhibition
pyridoxal 5'-phosphate
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0.25 mM, 14% inhibition
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2-mercaptoethanol
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stimulation
dithiothreitol
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stimulation
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7.2
glycerol 1,2-cyclic phosphate
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6.9
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beta,beta-dimethylglutarate buffer
7.4
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imidazole /HCl buffer
7.5
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glycylglycine buffer
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low activity
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low activity
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Clarke, N.; Dawson, R.M.C.
rac-Glycerol 1:2-cyclic phosphate 2-phosphodiesterase, a new soluble phosphodiesterase of mammalian tissues
Biochem. J.
173
579-589
1978
Cavia porcellus, Ovis aries, Mus musculus, Rattus norvegicus, Sus scrofa
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Clarke, N.; Dawson, R.M.C.
Enzymic formation of glycerol 1:2-cyclic phosphate
Biochem. J.
153
745-747
1976
Rattus norvegicus
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