Disease on EC 3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase
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Acute Coronary Syndrome
Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay.
alkylglycerophosphoethanolamine phosphodiesterase deficiency
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Alzheimer Disease
Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.
Alzheimer Disease
Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases.
Ankylosis
[Updates on Rickets and Osteomalacia. Mechanism and regulation of bone mineralization.]
Aortic Valve Stenosis
Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.
Arthritis, Rheumatoid
Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases.
Asthma
Autotaxinproduction of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation.
Asthma
Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms.
Atherosclerosis
Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction.
Atherosclerosis
Increased formation of lysophosphatidic acids by lysophospholipase D in serum of hypercholesterolemic rabbits.
Atherosclerosis
Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids.
Autoimmune Diseases
LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Blister
Production of lysophosphatidic acid in blister fluid: involvement of a lysophospholipase D activity.
Breast Neoplasms
ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro.
Breast Neoplasms
Identification of large-scale molecular changes of Autotaxin(ENPP2) knock-down by small interfering RNA in breast cancer cells.
Breast Neoplasms
Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy.
Breast Neoplasms
Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1.
Carcinogenesis
Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression.
Carcinogenesis
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Carcinogenesis
Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis.
Carcinoma
Activity and clinical relevance of autotaxin and lysophosphatidic acid pathways in high-grade serous carcinoma.
Carcinoma
Lack of significant differences in the corrected activity of lysophospholipase D, producer of phospholipid mediator lysophosphatidic acid, in incubated serum from women with and without ovarian tumors.
Carcinoma
Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody-Drug Conjugates.
Carcinoma, Hepatocellular
Cholera toxin inhibits human hepatocarcinoma cell proliferation in vitro via suppressing ATX/LPA axis.
Carcinoma, Hepatocellular
Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.
Carcinoma, Hepatocellular
Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma.
Carcinoma, Hepatocellular
Proteomics Based Identification of Autotaxin As An Anti-Hepatitis B Virus Factor and a Promoter of Hepatoma Cell Invasion and Migration.
Carcinoma, Renal Cell
Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody-Drug Conjugates.
Cataract
Autotaxin-lysophosphatidic Acid axis is a novel molecular target for lowering intraocular pressure.
Cataract
Effect of postoperative corticosteroids on surgical outcome and aqueous autotaxin following combined cataract and microhook ab interno trabeculotomy.
Cholera
Cholera toxin inhibits human hepatocarcinoma cell proliferation in vitro via suppressing ATX/LPA axis.
Cholestasis, Intrahepatic
Role of the placenta in serum autotaxin elevation during maternal cholestasis.
Choroid Plexus Neoplasms
OTX2 Defines a Subgroup of Atypical Teratoid Rhabdoid Tumors With Close Relationship to Choroid Plexus Tumors.
Coinfection
Plasma proteome analysis reveals overlapping, yet distinct mechanisms of immune activation in chronic HCV and HIV infections.
Colitis
Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.
Colonic Neoplasms
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma.
Colorectal Neoplasms
Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.
Colorectal Neoplasms
Immunohistochemical Detection of Autotaxin (ATX)/Lysophospholipase D (lysoPLD) in Submucosal Invasive Colorectal Cancer.
Corneal Injuries
Lysophospholipids and lysophospholipase D in rabbit aqueous humor following corneal injury.
Cysts
LPAR2 and LPAR4 are the Main Receptors Responsible for LPA Actions in Ovarian Endometriotic Cysts.
Dermatitis, Atopic
Increased lysophospholipase D activity of autotaxin in sera of patients with atopic dermatitis.
Diabetes Mellitus, Type 2
Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Contribution of ENPP1, TCF7L2, and FTO polymorphisms to type 2 diabetes in mixed ancestry ethnic population of South Africa.
Diabetes Mellitus, Type 2
Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity.
Diabetic Nephropathies
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.
Diabetic Nephropathies
Higher serum levels of autotaxin and phosphatidylserine-specific phospholipase A1 in patients with lupus nephritis.
Diabetic Nephropathies
Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy.
Diabetic Retinopathy
Expression of autotaxin and acylglycerol kinase in proliferative vitreoretinal epiretinal membranes.
Diabetic Retinopathy
Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy.
Disseminated Intravascular Coagulation
The pathological effects of Heminecrolysin, a dermonecrotic toxin from Hemiscorpius lepturus scorpion venom are mediated through its lysophospholipase D activity.
Endometrial Neoplasms
The significance of the altered expression of lysophosphatidic acid receptors, autotaxin and phospholipase A2 as the potential biomarkers in type 1 endometrial cancer biology.
Epiretinal Membrane
Expression of autotaxin and acylglycerol kinase in proliferative vitreoretinal epiretinal membranes.
Epstein-Barr Virus Infections
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells.
Esophageal Neoplasms
Specific increase in serum autotaxin activity in patients with pancreatic cancer.
Fatty Liver
Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease.
Fatty Liver
Human GDPD3 overexpression promotes liver steatosis by increasing lysophosphatidic acid production and fatty acid uptake.
Fatty Liver
Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease.
Fibromyalgia
CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia.
Glaucoma
Aqueous autotaxin and TGF-?s are promising diagnostic biomarkers for distinguishing open-angle glaucoma subtypes.
Glaucoma
Autotaxin-lysophosphatidic Acid axis is a novel molecular target for lowering intraocular pressure.
Glaucoma
Autotaxin-Lysophosphatidic Acid Pathway in Intraocular Pressure Regulation and Glaucoma Subtypes.
Glaucoma
Effect of postoperative corticosteroids on surgical outcome and aqueous autotaxin following combined cataract and microhook ab interno trabeculotomy.
Glaucoma
Higher serum levels of autotaxin and phosphatidylserine-specific phospholipase A1 in patients with lupus nephritis.
Glaucoma
Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity.
Glaucoma, Open-Angle
Autotaxin-lysophosphatidic Acid axis is a novel molecular target for lowering intraocular pressure.
Glaucoma, Open-Angle
Effect of postoperative corticosteroids on surgical outcome and aqueous autotaxin following combined cataract and microhook ab interno trabeculotomy.
Glioblastoma
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes.
Glioma
Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets.
Glioma
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes.
Hepatic Encephalopathy
Lysophosphatidic acid receptor, LPA6, regulates endothelial blood-brain barrier function: Implication for hepatic encephalopathy.
Hepatitis C
Serum autotaxin is a parameter for the severity of liver cirrhosis and overall survival in patients with liver cirrhosis--a prospective cohort study.
Hepatitis C, Chronic
Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.
Hepatitis C, Chronic
Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity.
Hodgkin Disease
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells.
Hyperglycemia
High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells.
Idiopathic Pulmonary Fibrosis
Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.
Infections
Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.
Infertility, Male
Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice.
Insulin Resistance
Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan.
Insulin Resistance
Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.
Insulin Resistance
Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity.
Liver Cirrhosis
Association of serum autotaxin levels with liver fibrosis in patients pretreatment and posttreatment with chronic hepatitis C.
Liver Cirrhosis
Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease.
Liver Cirrhosis
Changes in serum levels of autotaxin with direct-acting antiviral therapy in patients with chronic hepatitis C.
Liver Cirrhosis
Effect of histidine on autotaxin activity in experimentally induced liver fibrosis.
Liver Cirrhosis
Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.
Liver Cirrhosis
Post-Treatment M2BPGi Level and the Rate of Autotaxin Reduction are Predictive of Hepatocellular Carcinoma Development after Antiviral Therapy in Patients with Chronic Hepatitis C.
Liver Cirrhosis
Serum autotaxin is a parameter for the severity of liver cirrhosis and overall survival in patients with liver cirrhosis--a prospective cohort study.
Liver Cirrhosis
Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis.
Liver Diseases
Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease.
Liver Diseases
Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.
Liver Diseases
Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease.
Liver Neoplasms
Metabolomic study of the intervention effects of Shuihonghuazi Formula, a Traditional Chinese Medicinal formulae, on hepatocellular carcinoma (HCC) rats using performance HPLC/ESI-TOF-MS.
Lung Neoplasms
Lung cancer alters the hydrolysis of nucleotides and nucleosides in platelets.
Melanoma
Anti-melanoma activity of Forsythiae Fructus aqueous extract in mice involves regulation of glycerophospholipid metabolisms by UPLC/Q-TOF MS-based metabolomics study.
Melanoma
Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma.
Melanoma
ATX expression and LPA signalling are vital for the development of the nervous system.
Melanoma
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
Melanoma
Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities.
Melanoma
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid.
Melanoma
Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.
Melanoma
Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials.
Melanoma
Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma.
Melanoma
Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells.
Melanoma
Higher serum levels of autotaxin and phosphatidylserine-specific phospholipase A1 in patients with lupus nephritis.
Melanoma
Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion.
Melanoma
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.
Melanoma
IL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA).
Melanoma
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
Melanoma
Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma.
Melanoma
Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD).
Melanoma
Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme.
Melanoma
The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide.
Melanoma
Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.
Mesothelioma
Autotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesothelia.
Neoplasm Metastasis
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer.
Neoplasm Metastasis
alpha-Substituted Phosphonate Analogues of Lysophosphatidic Acid (LPA) Selectively Inhibit Production and Action of LPA.
Neoplasm Metastasis
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.
Neoplasm Metastasis
ATX-LPA Axis Induces Expression of OPN in Hepatic Cancer Cell SMMC7721.
Neoplasm Metastasis
ATX-LPA axis induces expression of OPN in hepatic cancer cell SMMC7721.
Neoplasm Metastasis
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Neoplasm Metastasis
Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis.
Neoplasm Metastasis
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.
Neoplasm Metastasis
Autotaxin-? interaction with the cell surface via syndecan-4 impacts on cancer cell proliferation and metastasis.
Neoplasm Metastasis
Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness.
Neoplasm Metastasis
Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin.
Neoplasm Metastasis
Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: Influence of Gleason score, treatment and bone metastasis.
Neoplasm Metastasis
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Neoplasm Metastasis
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
Neoplasm Metastasis
Kinetic Analysis of Autotaxin Reveals Substrate-specific Catalytic Pathways and a Mechanism for Lysophosphatidic Acid Distribution.
Neoplasm Metastasis
Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression.
Neoplasm Metastasis
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes.
Neoplasm Metastasis
Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer.
Neoplasm Metastasis
Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.
Neoplasm Metastasis
Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer.
Neoplasm Metastasis
Suppression of metastasis of intravenously-inoculated B16/F10 melanoma cells by the novel ginseng-derived ingredient, gintonin: involvement of autotaxin inhibition.
Neoplasms
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer.
Neoplasms
ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro.
Neoplasms
Altered activity of lysophospholipase D, which produces bioactive lysophosphatidic acid and choline, in serum from women with pathological pregnancy.
Neoplasms
Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells.
Neoplasms
Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate.
Neoplasms
Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia.
Neoplasms
Autotaxin and vascular endothelial growth factor receptor-2 and -3 are related to vascular development during the progression of chronic viral hepatitis C.
Neoplasms
Autotaxin expression and its connection with the TNF-alpha-NF-kappaB axis in human hepatocellular carcinoma.
Neoplasms
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
Neoplasms
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Neoplasms
Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines.
Neoplasms
Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation.
Neoplasms
Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation.
Neoplasms
Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells.
Neoplasms
Autotaxin promotes the expression of matrix metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells.
Neoplasms
Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis.
Neoplasms
Autotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesothelia.
Neoplasms
Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration.
Neoplasms
Autotaxin stimulates urokinase-type plasminogen activator expression through phosphoinositide 3-kinase-Akt-nuclear [corrected] factor kappa B signaling cascade in human melanoma cells.
Neoplasms
Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms.
Neoplasms
Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression.
Neoplasms
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer.
Neoplasms
Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.
Neoplasms
Autotaxin-? interaction with the cell surface via syndecan-4 impacts on cancer cell proliferation and metastasis.
Neoplasms
Autotaxin: its role in biology of melanoma cells and as a pharmacological target.
Neoplasms
Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability.
Neoplasms
Crystalline silica particles induce DNA damage in respiratory epithelium by ATX secretion and Rac1 activation.
Neoplasms
Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors.
Neoplasms
Differential expression of nucleotide pyrophosphatase/phosphodiesterases by Walker 256 mammary cancer cells in solid tumors and malignant ascites.
Neoplasms
Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness.
Neoplasms
Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation.
Neoplasms
Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin.
Neoplasms
Ectonucleotide Pyrophosphatase/Phosphodiesterase (E-NPP) and Adenosine Deaminase (ADA) activities in patients with uterine cervix neoplasia.
Neoplasms
Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.
Neoplasms
Enzymatic activation of autotaxin by divalent cations without EF-hand loop region involvement.
Neoplasms
Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer.
Neoplasms
Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma.
Neoplasms
Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia.
Neoplasms
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Neoplasms
Hypoxia Downregulates LPP3 and Promotes the Spatial Segregation of ATX and LPP1 During Cancer Cell Invasion.
Neoplasms
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase.
Neoplasms
IL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA).
Neoplasms
Immunohistochemical Detection of Autotaxin (ATX)/Lysophospholipase D (lysoPLD) in Submucosal Invasive Colorectal Cancer.
Neoplasms
Kinetic Analysis of Autotaxin Reveals Substrate-specific Catalytic Pathways and a Mechanism for Lysophosphatidic Acid Distribution.
Neoplasms
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin.
Neoplasms
Lack of significant differences in the corrected activity of lysophospholipase D, producer of phospholipid mediator lysophosphatidic acid, in incubated serum from women with and without ovarian tumors.
Neoplasms
Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis.
Neoplasms
LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Neoplasms
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
Neoplasms
Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression.
Neoplasms
Lysophosphatidic Acid: Promoter of Cancer Progression and of Tumor Microenvironment Development. A Promising Target for Anticancer Therapies?
Neoplasms
Lysophosphatidic acids, cyclic phosphatidic acids and autotaxin as promising targets in therapies of cancer and other diseases.
Neoplasms
Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development.
Neoplasms
Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun.
Neoplasms
Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2).
Neoplasms
Non-invasive imaging of tumors by monitoring autotaxin activity using an enzyme-activated near-infrared fluorogenic substrate.
Neoplasms
OTX2 Defines a Subgroup of Atypical Teratoid Rhabdoid Tumors With Close Relationship to Choroid Plexus Tumors.
Neoplasms
Overexpression of autotaxin is associated with human renal cell carcinoma and bladder carcinoma and their progression.
Neoplasms
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.
Neoplasms
Phosphodiesterase-Ialpha/autotaxin (PD-Ialpha/ATX): a multifunctional protein involved in central nervous system development and disease.
Neoplasms
Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids.
Neoplasms
Positive Feedback between Vascular Endothelial Growth Factor-A and Autotaxin in Ovarian Cancer Cells.
Neoplasms
Proteomics Based Identification of Autotaxin As An Anti-Hepatitis B Virus Factor and a Promoter of Hepatoma Cell Invasion and Migration.
Neoplasms
Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells.
Neoplasms
Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.
Neoplasms
Retinoic acid-induced expression of autotaxin in N-myc-amplified neuroblastoma cells.
Neoplasms
Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer.
Neoplasms
Scalable purification and characterization of the extracellular domain of human autotaxin from prokaryotic cells.
Neoplasms
Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe.
Neoplasms
Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma.
Neoplasms
Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients.
Neoplasms
Simiao Pill Attenuates Collagen-Induced Arthritis in Rats through Suppressing the ATX-LPA and MAPK Signalling Pathways.
Neoplasms
Specific increase in serum autotaxin activity in patients with pancreatic cancer.
Neoplasms
Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD).
Neoplasms
Suppression of metastasis of intravenously-inoculated B16/F10 melanoma cells by the novel ginseng-derived ingredient, gintonin: involvement of autotaxin inhibition.
Neoplasms
Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.
Neoplasms
Synthesis of enantiopure 2-carba-cyclic phosphatidic acid and effects of its chirality on biological functions.
Neoplasms
Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.
Neoplasms
The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation.
Neoplasms
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site.
Neoplasms
Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression.
Neoplasms
Ultrafast and Predictive Mass Spectrometry-Based Autotaxin Assays for Label-Free Potency Screening.
Neoplasms
Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases.
Neoplasms
Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation.
Neoplasms
[Elucidation of the functional roles of lysophospholipid mediators and its application in laboratory medicine]
Neuralgia
Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.
Neuralgia
CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia.
Neuralgia
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Neuralgia
Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.
Neuroblastoma
Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin.
Neuroblastoma
Ectonucleotide pyrophosphatase/phosphodiesterase activity in Neuro-2a neuroblastoma cells: changes in expression associated with neuronal differentiation.
Neuroblastoma
Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma.
Neuroblastoma
Retinoic acid-induced expression of autotaxin in N-myc-amplified neuroblastoma cells.
Non-alcoholic Fatty Liver Disease
Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease.
Obesity
Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan.
Obesity
Genome-wide analysis identifies colonic genes differentially associated with serum leptin and insulin concentrations in C57BL/6J mice fed a high-fat diet.
Obesity
Involvement of autotaxin/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis.
Obesity
LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Obesity
Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity.
Ovarian Neoplasms
Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis.
Ovarian Neoplasms
Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids.
Pancreatic Diseases
Specific increase in serum autotaxin activity in patients with pancreatic cancer.
Persistent Infection
LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Prostatic Neoplasms
Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: Influence of Gleason score, treatment and bone metastasis.
Prostatic Neoplasms
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.
Pruritus
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Pruritus
Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders.
Pruritus
Serum autotaxin is increased in pruritus of cholestasis, but not of other origin and responds to therapeutic interventions.
Pulmonary Disease, Chronic Obstructive
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma.
Rectal Neoplasms
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma.
Sarcoma
c-Jun promotes cell migration and drives expression of the motility factor ENPP2 in soft tissue sarcomas.
Stomach Neoplasms
Short hairpin RNA targeting autotaxin reduces human gastric carcinoma AGS cell proliferative, migratory and invasive capabilities in vitro and causes tumor regression in vivo.
Thrombosis
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.
Tuberous Sclerosis
Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis.
Vitreoretinopathy, Proliferative
Expression of autotaxin and acylglycerol kinase in proliferative vitreoretinal epiretinal membranes.
Whooping Cough
Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities.
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