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Disease on EC 3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Coronary Syndrome
Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay.
alkylglycerophosphoethanolamine phosphodiesterase deficiency
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Alzheimer Disease
Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.
Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases.
Ankylosis
[Updates on Rickets and Osteomalacia. Mechanism and regulation of bone mineralization.]
Aortic Valve Stenosis
Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.
Arthritis
Increased autotaxin activity in multiple sclerosis.
Arthritis, Rheumatoid
Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases.
Asthma
Autotaxinproduction of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation.
Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms.
Atherosclerosis
Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction.
Increased formation of lysophosphatidic acids by lysophospholipase D in serum of hypercholesterolemic rabbits.
Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids.
Autoimmune Diseases
LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Blister
Production of lysophosphatidic acid in blister fluid: involvement of a lysophospholipase D activity.
Breast Neoplasms
ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro.
Identification of large-scale molecular changes of Autotaxin(ENPP2) knock-down by small interfering RNA in breast cancer cells.
Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy.
Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1.
Carcinogenesis
Autotaxin is a novel target of microRNA-101-3p.
Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression.
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Novel point mutations attenuate autotaxin activity.
Stat3 mediates expression of autotaxin in breast cancer.
Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis.
Carcinoma
Activity and clinical relevance of autotaxin and lysophosphatidic acid pathways in high-grade serous carcinoma.
Lack of significant differences in the corrected activity of lysophospholipase D, producer of phospholipid mediator lysophosphatidic acid, in incubated serum from women with and without ovarian tumors.
Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody-Drug Conjugates.
Carcinoma, Hepatocellular
Cholera toxin inhibits human hepatocarcinoma cell proliferation in vitro via suppressing ATX/LPA axis.
Expression of autotaxin mRNA in human hepatocellular carcinoma.
Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.
Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma.
Proteomics Based Identification of Autotaxin As An Anti-Hepatitis B Virus Factor and a Promoter of Hepatoma Cell Invasion and Migration.
Carcinoma, Renal Cell
Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody-Drug Conjugates.
Cardiovascular Diseases
Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance.
Cataract
Autotaxin-lysophosphatidic Acid axis is a novel molecular target for lowering intraocular pressure.
Effect of postoperative corticosteroids on surgical outcome and aqueous autotaxin following combined cataract and microhook ab interno trabeculotomy.
Cholera
Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors.
Cholera toxin inhibits human hepatocarcinoma cell proliferation in vitro via suppressing ATX/LPA axis.
Cholestasis, Intrahepatic
Role of the placenta in serum autotaxin elevation during maternal cholestasis.
Choroid Plexus Neoplasms
OTX2 Defines a Subgroup of Atypical Teratoid Rhabdoid Tumors With Close Relationship to Choroid Plexus Tumors.
Coinfection
Plasma proteome analysis reveals overlapping, yet distinct mechanisms of immune activation in chronic HCV and HIV infections.
Colitis
Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.
Colonic Neoplasms
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma.
Colorectal Neoplasms
Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.
Immunohistochemical Detection of Autotaxin (ATX)/Lysophospholipase D (lysoPLD) in Submucosal Invasive Colorectal Cancer.
Corneal Injuries
Lysophospholipids and lysophospholipase D in rabbit aqueous humor following corneal injury.
Cysts
LPAR2 and LPAR4 are the Main Receptors Responsible for LPA Actions in Ovarian Endometriotic Cysts.
Dermatitis, Atopic
Increased lysophospholipase D activity of autotaxin in sera of patients with atopic dermatitis.
Diabetes Mellitus, Type 2
Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.
Contribution of ENPP1, TCF7L2, and FTO polymorphisms to type 2 diabetes in mixed ancestry ethnic population of South Africa.
Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity.
Diabetic Nephropathies
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.
Higher serum levels of autotaxin and phosphatidylserine-specific phospholipase A1 in patients with lupus nephritis.
Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy.
Diabetic Retinopathy
Expression of autotaxin and acylglycerol kinase in proliferative vitreoretinal epiretinal membranes.
Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy.
Disseminated Intravascular Coagulation
The pathological effects of Heminecrolysin, a dermonecrotic toxin from Hemiscorpius lepturus scorpion venom are mediated through its lysophospholipase D activity.
Endometrial Neoplasms
The significance of the altered expression of lysophosphatidic acid receptors, autotaxin and phospholipase A2 as the potential biomarkers in type 1 endometrial cancer biology.
Epiretinal Membrane
Expression of autotaxin and acylglycerol kinase in proliferative vitreoretinal epiretinal membranes.
Epstein-Barr Virus Infections
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells.
Esophageal Neoplasms
Specific increase in serum autotaxin activity in patients with pancreatic cancer.
Fatty Liver
Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease.
Human GDPD3 overexpression promotes liver steatosis by increasing lysophosphatidic acid production and fatty acid uptake.
Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease.
Fibromyalgia
CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia.
Glaucoma
Aqueous autotaxin and TGF-?s are promising diagnostic biomarkers for distinguishing open-angle glaucoma subtypes.
Autotaxin-lysophosphatidic Acid axis is a novel molecular target for lowering intraocular pressure.
Autotaxin-Lysophosphatidic Acid Pathway in Intraocular Pressure Regulation and Glaucoma Subtypes.
Development of a Novel Intraocular-Pressure-Lowering Therapy Targeting ATX.
Effect of postoperative corticosteroids on surgical outcome and aqueous autotaxin following combined cataract and microhook ab interno trabeculotomy.
Higher serum levels of autotaxin and phosphatidylserine-specific phospholipase A1 in patients with lupus nephritis.
Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity.
Glaucoma, Open-Angle
Autotaxin-lysophosphatidic Acid axis is a novel molecular target for lowering intraocular pressure.
Effect of postoperative corticosteroids on surgical outcome and aqueous autotaxin following combined cataract and microhook ab interno trabeculotomy.
Glioblastoma
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes.
Glioma
Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets.
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes.
Hepatic Encephalopathy
Lysophosphatidic acid receptor, LPA6, regulates endothelial blood-brain barrier function: Implication for hepatic encephalopathy.
Hepatitis C
Serum autotaxin is a parameter for the severity of liver cirrhosis and overall survival in patients with liver cirrhosis--a prospective cohort study.
Hepatitis C, Chronic
Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.
Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity.
Hodgkin Disease
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells.
Hyperglycemia
High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells.
Idiopathic Pulmonary Fibrosis
Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.
Druggable Lysophospholipid Signaling Pathways.
Infections
Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.
Infertility, Male
Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice.
Insulin Resistance
Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan.
Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.
ENPP2 contributes to adipose tissue expansion in diet-induced obesity.
Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity.
Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance.
Liver Cirrhosis
Association of serum autotaxin levels with liver fibrosis in patients pretreatment and posttreatment with chronic hepatitis C.
Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease.
Changes in serum levels of autotaxin with direct-acting antiviral therapy in patients with chronic hepatitis C.
Effect of histidine on autotaxin activity in experimentally induced liver fibrosis.
Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.
Lysophospholipids in laboratory medicine.
Post-Treatment M2BPGi Level and the Rate of Autotaxin Reduction are Predictive of Hepatocellular Carcinoma Development after Antiviral Therapy in Patients with Chronic Hepatitis C.
Serum autotaxin is a parameter for the severity of liver cirrhosis and overall survival in patients with liver cirrhosis--a prospective cohort study.
Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis.
Usefulness of autotaxin for the complications of liver cirrhosis.
Liver Diseases
Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease.
Autotaxin: An Early Warning Biomarker for Acute-on-chronic Liver Failure.
Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.
Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease.
Liver Neoplasms
Metabolomic study of the intervention effects of Shuihonghuazi Formula, a Traditional Chinese Medicinal formulae, on hepatocellular carcinoma (HCC) rats using performance HPLC/ESI-TOF-MS.
Lung Neoplasms
Lung cancer alters the hydrolysis of nucleotides and nucleosides in platelets.
The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis.
Melanoma
Anti-melanoma activity of Forsythiae Fructus aqueous extract in mice involves regulation of glycerophospholipid metabolisms by UPLC/Q-TOF MS-based metabolomics study.
Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma.
ATX expression and LPA signalling are vital for the development of the nervous system.
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities.
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid.
Autotaxin, Pruritus and Primary Biliary Cholangitis (PBC).
Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.
Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials.
Expression and regulation of Enpp2 in rat uterus during the estrous cycle.
Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma.
Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells.
Higher serum levels of autotaxin and phosphatidylserine-specific phospholipase A1 in patients with lupus nephritis.
Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion.
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.
IL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA).
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
Serum Autotaxin is not a Useful Biomarker for Ovarian Cancer.
Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma.
Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD).
Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme.
The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide.
Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.
[Significance of serum autotaxin activity in gastrointestinal disease]
Mesothelioma
Autotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesothelia.
Metabolic Diseases
ENPP2 contributes to adipose tissue expansion in diet-induced obesity.
Multiple Sclerosis
Increased autotaxin activity in multiple sclerosis.
Neoplasm Metastasis
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer.
alpha-Substituted Phosphonate Analogues of Lysophosphatidic Acid (LPA) Selectively Inhibit Production and Action of LPA.
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.
ATX-LPA Axis Induces Expression of OPN in Hepatic Cancer Cell SMMC7721.
ATX-LPA axis induces expression of OPN in hepatic cancer cell SMMC7721.
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis.
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.
Autotaxin-? interaction with the cell surface via syndecan-4 impacts on cancer cell proliferation and metastasis.
Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness.
Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin.
Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: Influence of Gleason score, treatment and bone metastasis.
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
Kinetic Analysis of Autotaxin Reveals Substrate-specific Catalytic Pathways and a Mechanism for Lysophosphatidic Acid Distribution.
Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression.
Lysophosphatidic Acid Signaling in Cancer.
Novel point mutations attenuate autotaxin activity.
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes.
Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer.
Pleiotropic activity of lysophosphatidic acid in bone metastasis.
Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.
Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer.
Suppression of metastasis of intravenously-inoculated B16/F10 melanoma cells by the novel ginseng-derived ingredient, gintonin: involvement of autotaxin inhibition.
[Significance of serum autotaxin activity in gastrointestinal disease]
Neoplasms
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer.
A sensitive screening assay for secreted motility-stimulating factors.
ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro.
Altered activity of lysophospholipase D, which produces bioactive lysophosphatidic acid and choline, in serum from women with pathological pregnancy.
An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases.
ATX-LPA Axis Induces Expression of OPN in Hepatic Cancer Cell SMMC7721.
ATX-LPA axis induces expression of OPN in hepatic cancer cell SMMC7721.
Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells.
Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate.
Autotaxin and LPA receptor signaling in cancer.
Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia.
Autotaxin and vascular endothelial growth factor receptor-2 and -3 are related to vascular development during the progression of chronic viral hepatitis C.
Autotaxin expression and its connection with the TNF-alpha-NF-kappaB axis in human hepatocellular carcinoma.
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines.
Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.
Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation.
Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation.
Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells.
Autotaxin promotes the expression of matrix metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells.
Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis.
Autotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesothelia.
Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration.
Autotaxin stimulates urokinase-type plasminogen activator expression through phosphoinositide 3-kinase-Akt-nuclear [corrected] factor kappa B signaling cascade in human melanoma cells.
Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms.
Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression.
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer.
Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.
Autotaxin-? interaction with the cell surface via syndecan-4 impacts on cancer cell proliferation and metastasis.
Autotaxin: its role in biology of melanoma cells and as a pharmacological target.
Benzoxaboroles-Novel Autotaxin Inhibitors.
Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability.
Crystalline silica particles induce DNA damage in respiratory epithelium by ATX secretion and Rac1 activation.
Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer.
Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors.
Differential expression of nucleotide pyrophosphatase/phosphodiesterases by Walker 256 mammary cancer cells in solid tumors and malignant ascites.
Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness.
Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation.
Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin.
Ectonucleotide Pyrophosphatase/Phosphodiesterase (E-NPP) and Adenosine Deaminase (ADA) activities in patients with uterine cervix neoplasia.
Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.
Enzymatic activation of autotaxin by divalent cations without EF-hand loop region involvement.
Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer.
Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma.
Expression, regulation and function of autotaxin in thyroid carcinomas.
Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia.
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Hypoxia Downregulates LPP3 and Promotes the Spatial Segregation of ATX and LPP1 During Cancer Cell Invasion.
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase.
IL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA).
Immunohistochemical Detection of Autotaxin (ATX)/Lysophospholipase D (lysoPLD) in Submucosal Invasive Colorectal Cancer.
Increased autotaxin activity in multiple sclerosis.
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
Kinetic Analysis of Autotaxin Reveals Substrate-specific Catalytic Pathways and a Mechanism for Lysophosphatidic Acid Distribution.
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin.
Lack of significant differences in the corrected activity of lysophospholipase D, producer of phospholipid mediator lysophosphatidic acid, in incubated serum from women with and without ovarian tumors.
Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis.
LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression.
Lysophosphatidic Acid Signaling in Cancer.
Lysophosphatidic Acid: Promoter of Cancer Progression and of Tumor Microenvironment Development. A Promising Target for Anticancer Therapies?
Lysophosphatidic acids, cyclic phosphatidic acids and autotaxin as promising targets in therapies of cancer and other diseases.
Lysophospholipids in the limelight: autotaxin takes center stage.
Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development.
Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun.
Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2).
New insights into the autotaxin/LPA axis in cancer development and metastasis.
Non-invasive imaging of tumors by monitoring autotaxin activity using an enzyme-activated near-infrared fluorogenic substrate.
Novel point mutations attenuate autotaxin activity.
OTX2 Defines a Subgroup of Atypical Teratoid Rhabdoid Tumors With Close Relationship to Choroid Plexus Tumors.
Overexpression of autotaxin is associated with human renal cell carcinoma and bladder carcinoma and their progression.
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.
Pharmacophoric Site Identification and Inhibitor Design for Autotaxin.
Phosphodiesterase-Ialpha/autotaxin (PD-Ialpha/ATX): a multifunctional protein involved in central nervous system development and disease.
Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids.
Pleiotropic activity of lysophosphatidic acid in bone metastasis.
Positive Feedback between Vascular Endothelial Growth Factor-A and Autotaxin in Ovarian Cancer Cells.
Proteomics Based Identification of Autotaxin As An Anti-Hepatitis B Virus Factor and a Promoter of Hepatoma Cell Invasion and Migration.
Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells.
Regulation and biological activities of the autotaxin-LPA axis.
Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.
Regulation of Tumor Immunity by Lysophosphatidic Acid.
Retinoic acid-induced expression of autotaxin in N-myc-amplified neuroblastoma cells.
Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer.
S100A8/A9 activate key genes and pathways in colon tumor progression.
Scalable purification and characterization of the extracellular domain of human autotaxin from prokaryotic cells.
Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe.
Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma.
Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients.
Simiao Pill Attenuates Collagen-Induced Arthritis in Rats through Suppressing the ATX-LPA and MAPK Signalling Pathways.
Specific increase in serum autotaxin activity in patients with pancreatic cancer.
Stat3 mediates expression of autotaxin in breast cancer.
Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD).
Suppression of metastasis of intravenously-inoculated B16/F10 melanoma cells by the novel ginseng-derived ingredient, gintonin: involvement of autotaxin inhibition.
Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.
Synthesis of enantiopure 2-carba-cyclic phosphatidic acid and effects of its chirality on biological functions.
Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.
The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation.
The FOXM1/ATX signaling contributes to pancreatic cancer development.
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site.
Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression.
Ultrafast and Predictive Mass Spectrometry-Based Autotaxin Assays for Label-Free Potency Screening.
Uncovering unique roles of LPA receptors in the tumor microenvironment.
Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases.
Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation.
[Elucidation of the functional roles of lysophospholipid mediators and its application in laboratory medicine]
[Significance of serum autotaxin activity in gastrointestinal disease]
Neuralgia
Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.
CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia.
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.
Neuroblastoma
Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin.
Ectonucleotide pyrophosphatase/phosphodiesterase activity in Neuro-2a neuroblastoma cells: changes in expression associated with neuronal differentiation.
Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma.
Retinoic acid-induced expression of autotaxin in N-myc-amplified neuroblastoma cells.
Non-alcoholic Fatty Liver Disease
Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease.
Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease.
Obesity
Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan.
Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.
ENPP2 contributes to adipose tissue expansion in diet-induced obesity.
Genome-wide analysis identifies colonic genes differentially associated with serum leptin and insulin concentrations in C57BL/6J mice fed a high-fat diet.
Involvement of autotaxin/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis.
LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity.
Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance.
Ovarian Neoplasms
Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis.
Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids.
Pancreatic Diseases
Specific increase in serum autotaxin activity in patients with pancreatic cancer.
Persistent Infection
LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Prostatic Neoplasms
Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: Influence of Gleason score, treatment and bone metastasis.
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.
Pruritus
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Pathogenesis and Management of Pruritus in PBC and PSC.
Reduced spontaneous itch in mouse models of cholestasis.
Role of the placenta in serum autotaxin elevation during maternal cholestasis.
Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders.
Serum autotaxin is increased in pruritus of cholestasis, but not of other origin and responds to therapeutic interventions.
The molecular mechanism of cholestatic pruritus.
Pulmonary Disease, Chronic Obstructive
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma.
Rectal Neoplasms
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma.
Retinal Vein Occlusion
LYSOPHOSPHATIDIC ACIDS AND AUTOTAXIN IN RETINAL VEIN OCCLUSION.
Sarcoma
c-Jun promotes cell migration and drives expression of the motility factor ENPP2 in soft tissue sarcomas.
Scleroderma, Systemic
Druggable Lysophospholipid Signaling Pathways.
Stomach Neoplasms
Analysis of glycero-lysophospholipids in gastric cancerous ascites.
Short hairpin RNA targeting autotaxin reduces human gastric carcinoma AGS cell proliferative, migratory and invasive capabilities in vitro and causes tumor regression in vivo.
Thrombosis
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.
Tuberous Sclerosis
Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis.
Vitreoretinopathy, Proliferative
Expression of autotaxin and acylglycerol kinase in proliferative vitreoretinal epiretinal membranes.
Whooping Cough
Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities.