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Disease on EC 3.1.4.11 - phosphoinositide phospholipase C and Organism(s) Homo sapiens

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DISEASE
TITLE OF PUBLICATION
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Adenocarcinoma
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S.
Conservation of a common motif in enzymes catalyzing ADP-ribose transfer. Identification of domains in mammalian transferases.
Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase ?1 expression.
Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes.
Novel functional variants locus in PLCE1 and susceptibility to digestive tract cancer in the Chinese population: A meta-analysis.
Prognostic value of PLCE1 expression in upper gastrointestinal cancer: a systematic review and meta-analysis.
Regulatory role of arginine 204 in the catalytic activity of rat alloantigens ART2a and ART2b.
Release of carcinoembryonic antigen from human tumor cells by phosphatidylinositol-specific phospholipase C: highly effective extraction and upregulation from LS-174T colonic adenocarcinoma cells.
Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population.
The Correlation between Phospholipase C Epsilon (PLCE1) Gene Polymorphisms and Risk of Gastric Adenocarcinoma in Iranian Population.
Adenoma
Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.
Adenomatous Polyposis Coli
Growth inhibition by phospholipase C inhibitor peptides of colorectal carcinoma cells derived from familial adenomatous polyposis.
Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.
Overexpression of phospholipase C-gamma1 in rat 3Y1 fibroblast cells leads to malignant transformation.
Adrenocortical Carcinoma
Stimulation of guanosine 3',5'-monophosphate-phosphodiesterase activity by adrenocorticotropic hormone-activated increase of guanosine 3',5'-monophosphate in isolated adrenocortical carcinoma cells.
Agammaglobulinemia
Bruton's tyrosine kinase and phospholipase Cgamma2 mediate chemokine-controlled B cell migration and homing.
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.
Alopecia
Lack of phospholipase C-delta1 induces skin inflammation.
Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development.
Alzheimer Disease
Aberrant accumulation of phospholipase C-delta in Alzheimer brains.
Aberrant phosphoinositide metabolism in Alzheimer's disease.
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease.
Changes in platelet phospholipase C protein level and activity in Alzheimer's disease.
Differential involvement of phospholipase C isozymes in Alzheimer's disease.
Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons.
Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains.
Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease.
Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease.
Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3).
Anemia
Erythropoietin receptor-operated Ca2+ channels: activation by phospholipase C-gamma 1.
Arrhythmias, Cardiac
Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma.
Arthritis
Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.
Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells.
Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis.
Asthma
Simultaneous measurement of Ca2+ transients and changes in the cell volume and microviscosity of the plasma membrane in smooth muscle cells. Evaluation of the effect of formoterol.
Astrocytoma
Decrease in thromboxane A2 receptor expression by differentiation with dibutyryl cyclic AMP in 1321N1 human astrocytoma cells.
Expression pattern and sub-cellular distribution of phosphoinositide specific phospholipase C enzymes after treatment with U-73122 in rat astrocytoma cells.
Human astrocytes contain two distinct angiotensin receptor subtypes.
Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in astrocytoma cells.
Molecular cloning and characterization of PLC-eta2.
Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells.
Phospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells.
Protein kinase C modulation of phosphoinositidase C in 1321N1 human astrocytoma cells.
Removal of C6 astrocytoma cell surface molecules with phosphatidylinositol phospholipase C: effect on regulation of neural cell adhesion molecule isoforms.
Atherosclerosis
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.
Autoimmune Diseases
Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells.
Bacterial Infections
Inhibition of phosphoinositide-specific phospholipase C results in the induction of pathogenesis-related genes in soybean.
Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells.
Bone Resorption
Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase.
Brain Diseases
Location-dependent role of phospholipase C signaling in the brain: Physiology and pathology.
Brain Injuries
Regional activities of phospholipase C after experimental brain injury in the rat.
Regional levels of phospholipase Cgamma after fluid percussion brain injury in the rat.
Brain Ischemia
Alteration of phosphoinositide degradation by cytosolic and membrane-bound phospholipases after forebrain ischemia-reperfusion in gerbil: effects of amyloid beta peptide.
Brain ischemia decreases phosphatidylcholine-phospholipase D but not phosphatidylinositol-phospholipase C in rats.
Breast Neoplasms
A common cofilin activity cycle in invasive tumor cells and inflammatory cells.
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
Antitumour effects of PLC-gamma1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells.
BetaPix-a enhances the activity of phospholipase Cgamma1 by binding SH3 domain in breast cancer.
Cells transformed by PLC-gamma 1 overexpression are highly sensitive to clostridium difficile toxin A-induced apoptosis and mitotic inhibition.
Effects of protein kinase Cdelta and phospholipase C-gamma1 on monocyte chemoattractant protein-1 expression in taxol-induced breast cancer cell death.
Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.
Elevated membrane association of phospholipase C-gamma 1 in MDA-468 mammary tumor cells.
Expression of phospholipase C-gamma 1 and its transcriptional regulators in breast cancer tissues.
miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer.
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells.
Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Phospholipase Cgamma1 is required for metastasis development and progression.
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Rebuttal to Letter-to-Editor on 'Distinction between PC-PLC and PI-PLC needs clarification' received for our manuscript titled "Diospyrin derivative, an anticancer quinonoid, regulates apoptosis at endoplasmic reticulum as well as mitochondria by modulating cytosolic calcium in human breast carcinoma cells" [BBRC 417 (2012) 903-909].
The urokinase plasminogen activator receptor (uPAR) promotes efferocytosis of apoptotic cells.
Bronchial Spasm
Simultaneous measurement of Ca2+ transients and changes in the cell volume and microviscosity of the plasma membrane in smooth muscle cells. Evaluation of the effect of formoterol.
Burkitt Lymphoma
Evidence for nuclear phosphoinositidase C activity in the antiproliferative signals produced by interferon in Burkitt lymphoma cells.
Nuclear phosphoinositide signalling enzyme in human B lymphoid cells.
Phosphoinositidase C beta 1 isoform expression is modulated by interferon alpha in Burkitt lymphoma cells.
Carcinogenesis
Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA.
Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis.
Association of Potentially Functional Genetic Variants of PLCE1 with Gallbladder Cancer Susceptibility in North Indian Population.
Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate.
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.
Crucial role of phospholipase Cepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity.
Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer.
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.
Genetic and pharmacologic dissection of ras effector utilization in oncogenesis.
Identification of a PLCE1?regulated competing endogenous RNA regulatory network for esophageal squamous cell carcinoma.
Meta-analysis of phospholipase C epsilon 1 polymorphism and cancer risk.
Modulating effect of amount and types of dietary fat on colonic mucosal phospholipase A2, phosphatidylinositol-specific phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male F344 rats.
Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.
Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir Valley.
Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley.
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.
PLC-?1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers.
PLC?1: a potential target of RNA interference therapy for gastric cancer.
PLCE1 rs2274223 A>G polymorphism and cancer risk: a meta-analysis.
Recent advances in understanding the molecular role of phosphoinositide-specific phospholipase C gamma 1 as an emerging onco-driver and novel therapeutic target in human carcinogenesis.
The hamster model of sequential oral oncogenesis.
Carcinoma
A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.
CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells.
Characterization of the colorectal carcinoma-associated antigen defined by monoclonal antibody D612.
Co-expression of alpha(1,3)galactosyltransferase and Bacillus thuringiensis PIPLC enhances hyperacute rejection of tumor cells.
Comprehensive bioinformatics analysis of the mRNA profile of PLCE1 knockdown in esophageal squamous cell carcinoma.
Comprehensive bioinformation analysis of the miRNA of PLCE1 knockdown in esophageal squamous cell carcinoma.
Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration.
Differential expression of a truncated form of the urokinase-type plasminogen-activator receptor in normal and tumor thyroid cells.
Effect of phosphatidylinositol-specific phospholipase C from Bacillus thuringiensis on solid spinocellular carcinoma.
Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues.
Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.
Elevated expression patterns and tight correlation of the PLCE1 and NF-?B signaling in Kazakh patients with esophageal carcinoma.
Expression of a 118 Kd protein in colon carcinoma cells that is immunologically related to PLC-gamma 1 and is augmented by serum-free conditions.
Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines.
Identification of a PLCE1?regulated competing endogenous RNA regulatory network for esophageal squamous cell carcinoma.
Membrane association and shedding of the GPI-anchored Ca-MOv18 antigen in human ovary carcinoma cells.
MicroRNA-145 performs as a tumor suppressor in human esophageal squamous cell carcinoma by targeting phospholipase C epsilon 1.
Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population.
Novel functional variants locus in PLCE1 and susceptibility to digestive tract cancer in the Chinese population: A meta-analysis.
Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: Based on published genome-wide association studies in a central Chinese population.
Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.
Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness.
Phosphatidylinositol-specific-phospholipase C cleaves urokinase plasminogen activator receptor from the cell surface and leads to inhibition of pemphigus-IgG-induced acantholysis in DJM-1 cells, a squamous cell carcinoma line.
Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion.
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis.
PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors.
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Prognostic value of PLCE1 expression in upper gastrointestinal cancer: a systematic review and meta-analysis.
Putatively Functional PLCE1 Variants and Susceptibility to Esophageal Squamous Cell Carcinoma (ESCC): A Case-Control Study in Eastern Chinese Populations.
Release of carcinoembryonic antigen from human tumor cells by phosphatidylinositol-specific phospholipase C: highly effective extraction and upregulation from LS-174T colonic adenocarcinoma cells.
Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population.
Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma.
Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma.
The Ca-MOv18 molecule, a cell-surface marker of human ovarian carcinomas, is anchored to the cell membrane by phosphatidylinositol.
The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis.
Topological regulation of cell-membrane phosphoinositidase C.
Two novel polymorphisms in PLCE1 are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population.
[Relationship between rs2274223 and rs3765524 polymorphisms of PLCE1 and risk of esophageal squamous cell carcinoma in a Kazakh Chinese population].
Carcinoma, Hepatocellular
Activation of H2O2-induced VSOR Cl- currents in HTC cells require phospholipase Cgamma1 phosphorylation and Ca2+ mobilisation.
An autocrine factor from Reuber hepatoma cells that stimulates DNA synthesis and acetyl-CoA carboxylase. Characterization of biologic activity and evidence for a glycan structure.
Identification of glycoinositol phospholipids in rat liver by reductive radiomethylation of amines but not in H4IIE hepatoma cells or isolated hepatocytes by biosynthetic labeling with glucosamine.
Phosphoinositide-specific phospholipase C?1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells.
Phospholipase C (EC 3.1.4.11): a malignancy linked signal transduction enzyme.
Purification and characterization of a major glycoprotein in rat hepatoma plasma membranes. One of the membrane proteins released by phosphatidylinositol-specific phospholipase C.
Purification and characterization of nuclear phospholipase C specific for phosphoinositides.
Carcinoma, Lobular
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Carcinoma, Non-Small-Cell Lung
PLCE1 inhibits apoptosis of non-small cell lung cancer via promoting PTEN methylation.
Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma.
Carcinoma, Squamous Cell
Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration.
EGF-dependent translocation of green fluorescent protein-tagged PLC-gamma1 to the plasma membrane and endosomes.
Epidermal growth factor activates phospholipase C in rat hepatocytes via a different mechanism from that in A431 or rat1hER cells.
Phosphatidylinositol-specific-phospholipase C cleaves urokinase plasminogen activator receptor from the cell surface and leads to inhibition of pemphigus-IgG-induced acantholysis in DJM-1 cells, a squamous cell carcinoma line.
Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis.
The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis.
Cardiomegaly
Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction.
Losartan attenuates phospholipase C isozyme gene expression in hypertrophied hearts due to volume overload.
Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy.
PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure.
Cataract
LncRNA PLCD3-OT1 Functions as a CeRNA to Prevent Age-Related Cataract by Sponging miR-224-5p and Regulating PLCD3 Expression.
Cherubism
SH3BP2 is an activator of NFAT activity and osteoclastogenesis.
Cholera
Actions of phorbol esters on levels of cAMP in cholera toxin-treated chief cells from guinea pig stomach.
Characterization of phosphatidylinositol-specific phospholipase C (PI-PLC) from Lilium daviddi pollen.
Potentiation by cholera toxin of bradykinin-induced inositol phosphate production in the osteoblast-like cell line MC3T3-E1.
Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction.
Signal transduction through the T cell antigen receptor. Activation of phospholipase C through a G protein-independent coupling mechanism.
Cholesteatoma
Expression of phospholipase C-gamma1 in experimental cholesteatoma using Mongolian gerbils.
Signal transduction pathway in human middle ear cholesteatoma.
Choroidal Neovascularization
Role of c-Cbl Dependent Regulation of Phospholipase C gamma 1 Activation in Experimental Choroidal Neovascularization.
Colitis, Ulcerative
Effect of PLC? gene silencing on inhibiting the cancerous transformation of ulcerative colitis.
Colonic Neoplasms
Effect of membrane lipid alteration on the growth, phospholipase C activity and G protein of HT-29 tumor cells.
Phosphoinositide-specific phospholipase C?1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells.
Reduced expression of phospholipase C-delta, a signal-transducing enzyme, in rat colon neoplasms induced by methylazoxymethanol acetate.
Release of carcinoembryonic antigen from human colon cancer cells by phosphatidylinositol-specific phospholipase C.
Colorectal Neoplasms
Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA.
Association between phospholipase C epsilon gene (PLCE1) polymorphism and colorectal cancer risk in a Chinese population.
Cells transformed by PLC-gamma 1 overexpression are highly sensitive to clostridium difficile toxin A-induced apoptosis and mitotic inhibition.
CircPLCE1 facilitates the malignant progression of colorectal cancer by repressing the SRSF2-dependent PLCE1 pre-RNA splicing.
Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues.
Genetic Variations in Phospholipase C-epsilon 1 (PLCE1) and Susceptibility to Colorectal Cancer Risk.
Growth inhibition by phospholipase C inhibitor peptides of colorectal carcinoma cells derived from familial adenomatous polyposis.
NF-kappaB and Hsp70 are involved in the phospholipase Cgamma1 signaling pathway in colorectal cancer cells.
Overexpression of phospholipase C-gamma 1 in colorectal carcinomas is associated with overexpression of factors that bind its promoter.
Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.
Overexpression of phospholipase C-gamma1 in rat 3Y1 fibroblast cells leads to malignant transformation.
Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer.
Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants.
The association between phospholipase C epsilon gene (PLCE1) polymorphisms and colorectal cancer risk in a Chinese Han population: a case-control study.
[Construction of lentivirus producing PLC-gamma1 siRNA and its effect on apoptosis of human colorectal carcinomas cell lines]
[Effects of blocking phospholipase C-gamma1 signaling pathway on proliferation and apoptosis of human colorectal cancer cell line LoVo]
Congenital Abnormalities
Defect in TCR-CD3zeta signaling mediates T cell hypo-responsiveness in mesenteric lymph node.
Craniosynostoses
Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway.
Dehydration
A gene encoding a phosphatidylinositol-specific phospholipase C is induced by dehydration and salt stress in Arabidopsis thaliana.
AtPLC2, a gene encoding phosphoinositide-specific phospholipase C, is constitutively expressed in vegetative and floral tissues in Arabidopsis thaliana.
Enhanced expression of phospholipase C 1 (ZmPLC1) improves drought tolerance in transgenic maize.
Dermatitis, Contact
Crucial role of phospholipase Cepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity.
Diabetic Nephropathies
EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells.
Disseminated Intravascular Coagulation
Phosphatidylinositol-specific phospholipase C, a possible virulence factor of Staphylococcus aureus.
Endometriosis
Expression of phosphoinositide-specific phospholipase C enzymes in normal endometrium and in endometriosis.
Endophthalmitis
Contribution of membrane-damaging toxins to Bacillus endophthalmitis pathogenesis.
Endotoxemia
Disruption of phospholipase C{gamma}1 signalling attenuates cardiac tumor necrosis factor-{alpha} expression and improves myocardial function during endotoxemia.
Phospholipase Cgamma1 signalling regulates lipopolysaccharide-induced cyclooxygenase-2 expression in cardiomyocytes.
Epilepsy
Location-dependent role of phospholipase C signaling in the brain: Physiology and pathology.
Escherichia coli Infections
Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase.
Esophageal Neoplasms
A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.
Heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations.
Hypomethylation-linked activation of PLCE1 impedes autophagy and promotes tumorigenesis through MDM2-mediated ubiquitination and destabilization of p53.
Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir Valley.
PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population.
PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail.
PLCE1 Promotes the Invasion and Migration of Esophageal Cancer Cells by Up-Regulating the PKC?/NF-?B Pathway.
PLCE1 suppresses p53 expression in esophageal cancer cells.
Esophageal Squamous Cell Carcinoma
Comprehensive bioinformatics analysis of the mRNA profile of PLCE1 knockdown in esophageal squamous cell carcinoma.
Comprehensive bioinformation analysis of the miRNA of PLCE1 knockdown in esophageal squamous cell carcinoma.
Elevated expression patterns and tight correlation of the PLCE1 and NF-?B signaling in Kazakh patients with esophageal carcinoma.
Identification of a PLCE1?regulated competing endogenous RNA regulatory network for esophageal squamous cell carcinoma.
MicroRNA-145 performs as a tumor suppressor in human esophageal squamous cell carcinoma by targeting phospholipase C epsilon 1.
Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population.
Novel functional variants locus in PLCE1 and susceptibility to digestive tract cancer in the Chinese population: A meta-analysis.
Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: Based on published genome-wide association studies in a central Chinese population.
Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness.
Prognostic value of PLCE1 expression in upper gastrointestinal cancer: a systematic review and meta-analysis.
Putatively Functional PLCE1 Variants and Susceptibility to Esophageal Squamous Cell Carcinoma (ESCC): A Case-Control Study in Eastern Chinese Populations.
Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population.
Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma.
Two novel polymorphisms in PLCE1 are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population.
[Relationship between rs2274223 and rs3765524 polymorphisms of PLCE1 and risk of esophageal squamous cell carcinoma in a Kazakh Chinese population].
Esophagitis
A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.
Fibroadenoma
Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.
Gangliosidoses, GM2
Altered phosphoinositide-specific phospholipase C and adenylyl cyclase in brain cortical membranes of cats with GM1 and GM2 gangliosidosis.
Gastritis, Atrophic
Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer.
Genetic Diseases, Inborn
Molecular genetic analysis of podocyte genes in focal segmental glomerulosclerosis--a review.
Gingival Overgrowth
Cyclosporin A upregulates phospholipase C beta1 in fibroblasts from gingival overgrowth.
Participation of tyrosine kinase and phospholipase Cgamma in isradipine-induced proliferation of cultured human gingival fibroblasts.
Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1.
Glioblastoma
Effects of phospholipase Cgamma on Polo-like kinase 1 expression in human glioma cells.
Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates.
Glioma
Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.
Differential Inhibitory Effects of 2-Azafluorenones on PI-PLC Activation but not on PC-PLC- or PC-PLD-Activation Induced by Histamine, PAF, PMA or A23187 in C6 Glioma Cells.
Effects of phospholipase Cgamma on Polo-like kinase 1 expression in human glioma cells.
Identification of phospholipase C gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration.
Inhibition of ecto-ATPase by PPADS, suramin and reactive blue in endothelial cells, C6 glioma cells and RAW 264.7 macrophages.
Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates.
Location-dependent role of phospholipase C signaling in the brain: Physiology and pathology.
Molecular forms of acetyl- and butyrylcholinesterase in human glioma.
Phospholipase C-delta1 expression is linked to proliferation, DNA synthesis, and cyclin E levels.
Potentiation of stimulus-induced phosphoinositide breakdown by calmodulin antagonists in C6 glioma cells.
T cell receptor-mediated signaling is defective in T cells obtained from patients with primary intracranial tumors.
Tissue- and cell type-specific expression of mRNAs for four types of inositol phospholipid-specific phospholipase C.
Two forms of phospholipase C-beta 1 generated by alternative splicing.
[Sensitization of human glioma SWO cell line to tumor necrosis factor-induced apoptosis by blocking phospholipase C-gamma1 signaling pathway]
Granuloma
Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1.
Granulomatosis with Polyangiitis
Association study with Wegener Granulomatosis of the human phospholipase Cgamma2 gene.
Heart Failure
Changes in sarcolemmal PLC isoenzymes in postinfarct congestive heart failure: partial correction by imidapril.
Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction.
Identification of changes in cardiac phospholipase C activity in congestive heart failure.
Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy.
Hemoglobinuria
CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.
Different membrane anchors of Fc gamma RIII (CD16) on K/NK-lymphocytes and neutrophils. Protein- vs lipid-anchor.
Fc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cells.
H19, a surface membrane molecule involved in T-cell activation, inhibits channel formation by human complement.
Monocyte antigen CD14 is a phospholipid anchored membrane protein.
Hemoglobinuria, Paroxysmal
CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.
Different membrane anchors of Fc gamma RIII (CD16) on K/NK-lymphocytes and neutrophils. Protein- vs lipid-anchor.
Fc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cells.
H19, a surface membrane molecule involved in T-cell activation, inhibits channel formation by human complement.
Monocyte antigen CD14 is a phospholipid anchored membrane protein.
Hepatitis
Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2.
Herpes Simplex
Reduction of HSV-1 binding to BHK cells after treatment with phosphatidylinositol-specific phospholipase C.
Herpes Zoster
Acetylcholine induces oscillations in intracellular calcium in isolated bovine adrenal zona fasciculata/reticularis cells.
Further characterization of the steroidogenic responsiveness of purified zona fasciculata/reticularis cells from bovine adrenal cortex before and after primary culture: changing responsiveness to phosphoinositidase C agonists.
Immunohistochemical analysis of AT1 receptor versus P450c17 and 3 beta HSD expression in ovine adrenals.
Molecular cloning and characterization of a novel phospholipase C, PLC-eta.
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate.
Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction.
Hodgkin Disease
Expression of intracellular signaling molecules in classical and lymphocyte predominance Hodgkin disease.
Hyperalgesia
GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.
PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia.
Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia.
Hypercalcemia
G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes.
Hypersensitivity
Humoral and delayed-type hypersensitive responses against listeria monocytogenes phosphatidylinositol-specific phospholipase C in experimentally infected buffaloes.
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.
Sphingolipid deficiency induces hypersensitivity of CD14, a glycosyl phosphatidylinositol-anchored protein, to phosphatidylinositol-specific phospholipase C.
Hypertension
Alterations of phosphoinositide-specific phospholipase C and protein kinase C in the myocardium of spontaneously hypertensive rats.
Attenuation of renomedullary phospholipase C isozyme, PLC-delta 1, in spontaneously hypertensive rats.
Enhancement of phospholipase C delta 1 activity in the aortas of spontaneously hypertensive rats.
Erythropoietin receptor-operated Ca2+ channels: activation by phospholipase C-gamma 1.
Phospholipase C activity is enhanced in skin fibroblasts obtained from patients with essential hypertension.
Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension.
Renal phospholipase C and diglyceride lipase activity in spontaneously hypertensive rats.
Hyperthyroidism
Effect of thyroid status on phosphatidylinositols in rat heart.
Hypothyroidism
Effect of thyroid status on phosphatidylinositols in rat heart.
Infections
Activation of host phospholipases C and D in macrophages after infection with Listeria monocytogenes.
Bacillus thuringiensis membrane-damaging toxins acting on mammalian cells.
Characterization of canine parvovirus (CPV) interactions with 3201 T cells: involvement of GPI-anchored protein(s) in binding and infection.
Differential function of Listeria monocytogenes listeriolysin O and phospholipases C in vacuolar dissolution following cell-to-cell spread.
Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase.
Hantavirus Causing Hemorrhagic Fever with Renal Syndrome Enters from the Apical Surface and Requires Decay-Accelerating Factor (DAF/CD55).
Humoral and delayed-type hypersensitive responses against listeria monocytogenes phosphatidylinositol-specific phospholipase C in experimentally infected buffaloes.
Identification of TAF1, SAT1, and ARHGEF9 as DNA methylation biomarkers for hepatocellular carcinoma.
Inhibition of phosphoinositide-specific phospholipase C results in the induction of pathogenesis-related genes in soybean.
Intimin-dependent binding of enteropathogenic Escherichia coli to host cells triggers novel signaling events, including tyrosine phosphorylation of phospholipase C-gamma1.
Listeria monocytogenes evades killing by autophagy during colonization of host cells.
Listeria monocytogenes phospholipase C-dependent calcium signaling modulates bacterial entry into J774 macrophage-like cells.
Localization of protein kinase C epsilon to macrophage vacuoles perforated by Listeria monocytogenes cytolysin.
Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase.
Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome.
Phosphatidylinositol-specific phospholipase C enhances epidermal penetration by Staphylococcus aureus.
Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune response.
Phosphatidylinositol-specific phospholipase C, a possible virulence factor of Staphylococcus aureus.
Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors.
Phospholipase C-gamma1 is required for the induction of immediate early genes by platelet-derived growth factor.
Phospholipase C/diacylglycerol kinase-mediated signalling is required for benzothiadiazole-induced oxidative burst and hypersensitive cell death in rice suspension-cultured cells.
PLC-?1 is involved in the inflammatory response induced by influenza A virus H1N1 infection.
Proteolytic pathways of activation and degradation of a bacterial phospholipase C during intracellular infection by Listeria monocytogenes.
Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells.
Reduction of HSV-1 binding to BHK cells after treatment with phosphatidylinositol-specific phospholipase C.
Roles of Listeria monocytogenes virulence factors in survival: virulence factors distinct from listeriolysin are needed for the organism to survive an early neutrophil-mediated host defense mechanism.
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody.
Simian virus 40 infection triggers a balanced network that includes apoptotic, survival, and stress pathways.
The invasion protein InIB from Listeria monocytogenes activates PLC-gamma1 downstream from PI 3-kinase.
The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism.
Two distinct phospholipases C of Listeria monocytogenes induce ceramide generation, nuclear factor-kappa B activation, and E-selectin expression in human endothelial cells.
Infertility
Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLC?) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells.
Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update.
Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization.
Nuclear Inositide Signaling via Phospholipase C.
Oocyte activation, phospholipase C zeta and human infertility.
Phospholipase C zeta (PLC?): Oocyte activation and clinical links to male factor infertility.
Infertility, Male
A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC?) leads to male infertility.
Increasing associations between defects in phospholipase C zeta and conditions of male infertility: not just ICSI failure?
Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization.
Phospholipase C zeta (PLC?) and male infertility: Clinical update and topical developments.
Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility.
The testicular and epididymal expression profile of PLC? in mouse and human does not support its role as a sperm-borne oocyte activating factor.
Influenza, Human
Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes.
PLC-?1 is involved in the inflammatory response induced by influenza A virus H1N1 infection.
PLC-?1 signaling plays a subtype-specific role in postbinding cell entry of influenza A virus.
Insulin Resistance
Effect of insulin and insulin-like growth factors I and II on phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate breakdown in liver from humans with and without type II diabetes.
Growth hormone inhibits activation of phosphatidylinositol phospholipase C by insulin in ob/ob mouse adipose tissue.
Hepatic insulin resistance in KKA(y) mice and its amelioration by pioglitazone do not involve alterations in phospholipase C activity.
Insulinoma
Enhanced phosphoinositide hydrolysis via overexpression of phospholipase C beta1 or delta1 inhibits stimulus-induced insulin release in insulinoma MIN6 cells.
Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion.
Intellectual Disability
Role of Phosphoinositide-Specific Phospholipase C ?2 in Isolated and Syndromic Mental Retardation.
Keratosis, Seborrheic
Altered distribution of phospholipase C-gamma 1 in benign hyperproliferative epidermal diseases.
Kidney Failure, Chronic
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
Leptospirosis
Leptospiral phosphatidylinositol-specific phospholipase C: a novel conserved antigen for the definitive diagnosis of Leptospirosis.
Leukemia
(-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase.
Activation of polyphosphoinositide phospholipase C by guanosine 5'-O-(3-thio)triphosphate and fluoroaluminate in membranes prepared from a human T cell leukemia line, JURKAT.
Characterization of glucocorticoid inhibition of antigen-induced inositolphosphate formation by rat basophilic leukemia cells: possible involvement of phosphatases.
Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.
Detergent-resistant membrane domains are required for mast cell activation but dispensable for tyrosine phosphorylation upon aggregation of the high affinity receptor for IgE.
Down-regulation of phospholipase C-gamma 1 during the differentiation of U937 cells.
Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor.
Fc epsilon RI-mediated hydrolysis of phosphoinositides in ghosts derived from rat basophilic leukemia cells.
Glucocorticoid inhibition of antigen-induced inositol phosphate formation: possible involvement of phosphatases.
Identification of functional receptors for ciliary neurotrophic factor on chick ciliary ganglion neurons.
Nuclear inositide signaling: an appraisal of phospholipase C beta1 behavior in myelodysplastic and leukemia cells.
P2-purinergic receptors activate a guanine nucleotide-dependent phospholipase C in membranes from HL-60 cells.
Potent activation of phospholipase D by phenylarsine oxide in rat basophilic leukemia (RBL-2H3) cells.
Purification and characterization of a phosphoinositide-specific phospholipase C from guinea pig uterus. Phosphorylation by protein kinase C in vivo.
Leukemia, Erythroblastic, Acute
Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization.
Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression.
Molecular forms of acetylcholinesterase in two sublines of human erythroleukemia K562 cells. Sensitivity or resistance to phosphatidylinositol-specific phospholipase C and biosynthesis.
Nuclear phospholipase C beta1 (PLCbeta1) affects CD24 expression in murine erythroleukemia cells.
Phospholipase C treatment of certain human target cells reduces their susceptibility to NK lysis without affecting binding or sensitivity to lytic granules.
Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation.
Proteomic-based analysis of nuclear signaling: PLCbeta1 affects the expression of the splicing factor SRp20 in Friend erythroleukemia cells.
Leukemia, Lymphoid
Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C.
Leukemia, Myeloid
Protective role of all-trans retinoic acid (ATRA) against hypoxia-induced malignant potential of non-invasive breast tumor derived cells.
Leukemia, Myeloid, Acute
Inositide-specific phospholipase c beta1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia.
Nuclear inositol lipid metabolism: more than just second messenger generation?
Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction.
Nuclear phospholipase C beta1, regulation of the cell cycle and progression of acute myeloid leukemia.
Nuclear phospholipase C: involvement in signal transduction.
Nuclear PI-PLC ?1 and Myelodysplastic syndromes: from bench to clinics.
Phosphoinositide phospholipase Cbeta1 (PI-PLCbeta1) gene in myelodysplastic syndromes and cytogenetically normal acute myeloid leukemia: not a deletion, but increased PI-PLCbeta1 expression is an independent prognostic factor.
Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia.
Phosphoinositide-specific phospholipase C beta1 signal transduction in the nucleus.
Synergistic induction of PI-PLC?1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes.
Leukemia, T-Cell
(-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase.
Activation of polyphosphoinositide phospholipase C by guanosine 5'-O-(3-thio)triphosphate and fluoroaluminate in membranes prepared from a human T cell leukemia line, JURKAT.
Phospholipase C treatment of certain human target cells reduces their susceptibility to NK lysis without affecting binding or sensitivity to lytic granules.
Lewy Body Disease
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Listeriosis
Role in virulence of phospholipases, listeriolysin O and listeriolysin S from epidemic Listeria monocytogenes using the chicken embryo infection model.
Liver Diseases
Deficient phospholipase C activity in blood polimorphonuclear neutrophils from patients with liver cirrhosis.
Phosphoinositide-specific phospholipase C in normal human liver and in alcohol abuse.
Lung Injury
Staphylococcal phosphatidylinositol-specific phospholipase C potentiates lung injury via complement sensitisation.
Lung Neoplasms
Human lung cancer cell lines express cell membrane complement inhibitory proteins and are extremely resistant to complement-mediated lysis; a comparison with normal human respiratory epithelium in vitro, and an insight into mechanism(s) of resistance.
PLCE1 inhibits apoptosis of non-small cell lung cancer via promoting PTEN methylation.
Lymphoma
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis.
Anchoring and degradation of glycolipid-anchored membrane proteins by L929 versus by LM-TK- mouse fibroblasts: implications for anchor biosynthesis.
Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells.
Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic leukemia cells.
Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.
Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor.
Evidence that murine hematopoietic cell subset marker J11d is attached to a glycosyl-phosphatidylinositol membrane anchor.
Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma.
Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity.
Nucleophosmin/B23, a multifunctional protein that can regulate apoptosis.
Role of c-Cbl Dependent Regulation of Phospholipase C gamma 1 Activation in Experimental Choroidal Neovascularization.
Sensitivity of receptors for IgA on T560, a murine B lymphoma, to phorbol myristate acetate and to phosphatidylinositol-specific phospholipase C.
Sodium butyrate causes reexpression of three membrane proteins on glycolipid-anchoring mutants.
Stimulation of Src family protein-tyrosine kinases as a proximal and mandatory step for SYK kinase-dependent phospholipase Cgamma2 activation in lymphoma B cells exposed to low energy electromagnetic fields.
Thy-1 supports adhesion of mouse thymocytes to thymic epithelial cells through a Ca2(+)-independent mechanism.
Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib.
Lymphoma, B-Cell
Intracellular signalling molecules as immunohistochemical markers of normal and neoplastic human leucocytes in routine biopsy samples.
Lymphoma, Large-Cell, Anaplastic
Nucleophosmin/B23, a multifunctional protein that can regulate apoptosis.
Lymphoma, T-Cell
Intracellular signalling molecules as immunohistochemical markers of normal and neoplastic human leucocytes in routine biopsy samples.
Malaria
Genetic and transcriptional analysis of phosphoinositide-specific phospholipase C in Plasmodium.
Mastocytoma
Phosphoinositide-specific phospholipase C of a cloned mast cell line, mastocytoma P-815: purification and some characterization.
Melanoma
Characterization of phosphatidylinositol phospholipase C activity in human melanoma.
Expression of protectin (CD59) in human melanoma and its functional role in cell- and complement-mediated cytotoxicity.
Levels of cell membrane CD59 regulate the extent of complement-mediated lysis of human melanoma cells.
Melanotransferrin is efficiently sorted on the surface of exosomes secreted by melanoma cells.
Membrane-bound regulators of complement activation in uveal melanomas. CD46, CD55, and CD59 in uveal melanomas.
Phospholipase C inhibitors: a new class of cytotoxic agents.
The urokinase plasminogen activator receptor (uPAR) promotes efferocytosis of apoptotic cells.
Meningioma
Biochemical properties of acetyl- and butyrylcholinesterase in human meningioma.
Characterization of molecular forms of acetyl- and butyrylcholinesterase in human acoustic neurinomas.
Monomers and dimers of acetylcholinesterase in human meningioma are anchored to the membrane by glycosylphosphatidylinositol.
The epidermal growth factor receptor is associated with phospholipase C-gamma 1 in meningiomas.
Multiple Endocrine Neoplasia
Exclusion of the phosphatidylinositol-specific phospholipase C beta 3 (PLC beta 3) gene as candidate for the multiple endocrine neoplasia type 1 (MEN 1) gene.
Exclusion of the phosphoinositide-specific phospholipase C beta 3 (PLCB3) gene as a candidate for multiple endocrine neoplasia type 1.
Multiple Endocrine Neoplasia Type 1
Exclusion of the phosphatidylinositol-specific phospholipase C beta 3 (PLC beta 3) gene as candidate for the multiple endocrine neoplasia type 1 (MEN 1) gene.
Exclusion of the phosphoinositide-specific phospholipase C beta 3 (PLCB3) gene as a candidate for multiple endocrine neoplasia type 1.
Murine Acquired Immunodeficiency Syndrome
Defective CD4+ T cell signaling in murine AIDS: uncoupling of the T cell receptor complex from PIP2 hydrolysis.
Muscular Dystrophies
In vitro studies on calcium activated phosphatidylinositol phosphodiesterase of erythrocyte ghosts from normal individuals and those with myotonic muscular dystrophy.
Myelodysplastic Syndromes
Deletion of the inositide-specific phospholipase c beta1 gene is a rare event in myelodysplastic syndrome and thus of limited value to predict leukemic progression.
Epigenetic regulation of nuclear PI-PLCbeta1 signaling pathway in low-risk MDS patients during azacitidine treatment.
Inositide-specific phospholipase c beta1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia.
Inositide-specific phospholipase c beta1 gene deletion is a rare event in myelodysplastic syndromes.
Nuclear phospholipase C: involvement in signal transduction.
Nuclear PI-PLC ?1 and Myelodysplastic syndromes: from bench to clinics.
Phosphoinositide phospholipase Cbeta1 (PI-PLCbeta1) gene in myelodysplastic syndromes and cytogenetically normal acute myeloid leukemia: not a deletion, but increased PI-PLCbeta1 expression is an independent prognostic factor.
Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia.
Phosphoinositide-specific phospholipase C beta1 signal transduction in the nucleus.
Phospholipase C beta1 (PI-PLCbeta1)/Cyclin D3/protein kinase C (PKC) alpha signaling modulation during iron-induced oxidative stress in myelodysplastic syndromes (MDS).
Real-time PCR as a tool for quantitative analysis of PI-PLCbeta1 gene expression in myelodysplastic syndrome.
Selective Activation of Nuclear PI-PLCbeta1 during Normal and Therapy-Related Differentiation.
Myocardial Infarction
Changes in sarcolemmal PLC isoenzymes in postinfarct congestive heart failure: partial correction by imidapril.
Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction.
Myocardial Ischemia
Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C.
[Phosphatidylinositol-specific phospholipase C in hypoxic rat myocardium]
Myotonic Dystrophy
Modulation of nuclear PI-PLCbeta1 during cell differentiation.
Neoplasm Metastasis
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells.
Antitumour effects of PLC-gamma1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells.
Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA.
Lentivirus-mediated PLC?1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma.
Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase ?1 expression.
Phosphoinositide-specific phospholipase C?1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells.
Phospholipase Cgamma1 is required for metastasis development and progression.
Phospholipase Cgamma1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade.
Neoplasms
1p36.32 rearrangements and the role of PI-PLC ?2 in nervous tumours.
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas.
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells.
Alkaline phosphodiesterase I release from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C. III. The release from tumor cells.
Amplified increase in signal transduction activity in cancer cells.
Analysis of the proliferative response to lysophosphatidic acid in primary cultures of mammary epithelium: differences between normal and tumor cells.
Antitumour effects of PLC-gamma1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells.
BetaPix-a enhances the activity of phospholipase Cgamma1 by binding SH3 domain in breast cancer.
Biosynthesis of carcinoembryonic antigen (CEA) gene family members expressed in human tumor cell lines: evidence for cleavage of the glycosyl phosphatidyl inositol (GPI) anchor by GPI-PLC and GPI-PLD.
Btk and phospholipase C gamma 2 can function independently during B cell development.
Changes in choline metabolism as potential biomarkers of phospholipase C{gamma}1 inhibition in human prostate cancer cells.
Characterization of phosphatidylinositol phospholipase C activity in human melanoma.
Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate.
Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.
Co-expression of alpha(1,3)galactosyltransferase and Bacillus thuringiensis PIPLC enhances hyperacute rejection of tumor cells.
Construction and identification of eukaryotic expression vector of human full-length PLCgamma1 gene.
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.
Dietary fat and fiber differentially alter intracellular second messengers during tumor development in rat colon.
Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes.
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.
Effect of Phospholipase C-gamma1 Overexpression on the Protein Level of Waf1, PCNA, and Cyclin B1 Following Ultraviolet C Irradiation.
Effect of PLC? gene silencing on inhibiting the cancerous transformation of ulcerative colitis.
Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate.
ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of fcepsilon receptor I-mediated activation of Syk.
ErbB receptors in the biology and pathology of the aerodigestive tract.
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.
Exclusion of the phosphatidylinositol-specific phospholipase C beta 3 (PLC beta 3) gene as candidate for the multiple endocrine neoplasia type 1 (MEN 1) gene.
Exclusion of the phosphoinositide-specific phospholipase C beta 3 (PLCB3) gene as a candidate for multiple endocrine neoplasia type 1.
Expression and characterization of glycolipid-anchored B7-1 (CD80) from baculovirus-infected insect cells: protein transfer onto tumor cells.
Expression of intracellular signaling molecules in classical and lymphocyte predominance Hodgkin disease.
Expression pattern and sub-cellular distribution of phosphoinositide specific phospholipase C enzymes after treatment with U-73122 in rat astrocytoma cells.
Formation, turnover, and sensitivity to phosphatidylinositol-specific phospholipase C of Thy-1 of a rat neuronal tumor cell line.
G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes.
Growth inhibition, enhancement of intercellular adhesion, and increased expression of carcinoembryonic antigen by overexpression of phosphoinositides-specific phospholipase C beta 1 in LS174T human colon adenocarcinoma cell line.
Highly effective extraction of carcinoembryonic antigen with phosphatidylinositol-specific phospholipase C.
Identification of a biochemical lesion, and characteristic response to lipopolysaccharide (LPS) of a cultured macrophage-like cell mutant with defective LPS-binding.
Identification of phospholipase C gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration.
Increased risk of developing digestive tract cancer in subjects carrying the PLCE1 rs2274223 A>G polymorphism: evidence from a meta-analysis.
Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates.
Inhibition of phospholipase Cgamma1 and cancer cell proliferation by lignans and flavans from Machilus thunbergii.
Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla.
Lentivirus-mediated PLC?1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma.
Membrane association and shedding of the GPI-anchored Ca-MOv18 antigen in human ovary carcinoma cells.
Meta-analysis of phospholipase C epsilon 1 polymorphism and cancer risk.
MicroRNA-145 performs as a tumor suppressor in human esophageal squamous cell carcinoma by targeting phospholipase C epsilon 1.
Modulating effect of amount and types of dietary fat on colonic mucosal phospholipase A2, phosphatidylinositol-specific phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male F344 rats.
Molecular inhibition of phospholipase cgamma signaling abrogates DU-145 prostate tumor cell invasion.
Negative regulatory role of overexpression of PLC gamma 1 in the expression of early growth response 1 gene in rat 3Y1 fibroblasts.
Overexpression of phosphoinositide-specific phospholipase Cgamma in NIH 3T3 cells promotes transformation and tumorigenicity.
Phosphoinositide-specific phospholipase C (PI-PLC) in health and disease.
Phosphoinositide-specific phospholipase C isoforms are conveyed by osteosarcoma-derived extracellular vesicles.
Phosphoinositide-specific phospholipase C?1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells.
Phospholipase C (EC 3.1.4.11): a malignancy linked signal transduction enzyme.
Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir Valley.
Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley.
Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma.
Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion.
Phospholipase C treatment of certain human target cells reduces their susceptibility to NK lysis without affecting binding or sensitivity to lytic granules.
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Phospholipase C-gamma1 in tumor progression.
Phospholipase C? Modulates Rap1 Activity and the Endothelial Barrier.
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.
Phospholipase Cgamma1 is required for metastasis development and progression.
Phospholipase Cgamma1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade.
Phosphorylation of glycogen synthase kinase-3beta at serine-9 by phospholipase Cgamma1 through protein kinase C in rat 3Y1 fibroblasts.
PLC-?1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers.
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
PLC? and the RASSF family in tumour suppression and other functions.
PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy.
Possible role of phospholipase C in the regulation of cell division in normal and neoplastic cells.
Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.
Preferential down-regulation of phospholipase C-beta in Ewing's sarcoma cells transfected with antisense EWS-Fli-1.
Prognostic relevance of MAPK expression in glioblastoma multiforme.
Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts.
Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells.
Reduced expression of phospholipase C-delta, a signal-transducing enzyme, in rat colon neoplasms induced by methylazoxymethanol acetate.
Release of carcinoembryonic antigen from human tumor cells by phosphatidylinositol-specific phospholipase C: highly effective extraction and upregulation from LS-174T colonic adenocarcinoma cells.
Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein.
Roles of ERK, PI3 kinase, and PLC-gamma pathways induced by overexpression of translationally controlled tumor protein in HeLa cells.
Semaphorin 4D signalling requires the recruitment of phospholipase C{gamma} into the plexin-B1 receptor complex.
Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants.
The CD24/P-selectin binding pathway initiates lung arrest of human A125 adenocarcinoma cells.
The controversial role of phospholipase C epsilon (PLC?) in cancer development and progression.
Transformation of rat fibroblasts by phospholipase C-gamma1 overexpression is accompanied by tyrosine dephosphorylation of paxillin.
Tumor necrosis factor-alpha promotes survival of opossum kidney cells via Cdc42-induced phospholipase C-gamma1 activation and actin filament redistribution.
Tumor necrosis factor-alpha stimulates phosphatidylinositol breakdown by phospholipase C to coordinately increase the levels of diacylglycerol, free arachidonic acid and prostaglandins in an osteoblast (MC3T3-E1) cell line.
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.
Validation of in vivo pharmacodynamic activity of a novel PDGF receptor tyrosine kinase inhibitor using immunohistochemistry and quantitative image analysis.
[Expression and Significance of PI-PLC?1 in Colon Cancer].
[Sensitization of human glioma SWO cell line to tumor necrosis factor-induced apoptosis by blocking phospholipase C-gamma1 signaling pathway]
Nephrotic Syndrome
Cyclosporine A responsive congenital nephrotic syndrome with single heterozygous variants in NPHS1, NPHS2, and PLCE1.
Identification of BRAF as a new interactor of PLCepsilon1, the protein mutated in nephrotic syndrome type 3.
Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome.
PLCE1 regulates the migration, proliferation, and differentiation of podocytes.
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
Neurilemmoma
Characterization of molecular forms of acetyl- and butyrylcholinesterase in human acoustic neurinomas.
Neuroblastoma
Agonist-induced endocytosis of muscarinic cholinergic receptors: relationship to stimulated phosphoinositide turnover.
Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site.
Antagonism by 8-hydroxy-2(di-n-propylamino)tetraline and other serotonin agonists of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human IMR-32 and SK-N-MC neuroblastoma cells.
Association of solubilized angiotensin II receptors with phospholipase C-alpha in murine neuroblastoma NIE-115 cells.
Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C.
Contribution of G protein activation to fluoride stimulation of phosphoinositide hydrolysis in human neuroblastoma cells.
Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors.
Heterologous desensitization of both phosphoinositide and Ca2+ signaling in SH-SY5Y neuroblastoma cells: a role for intracellular Ca2+ store depletion?
Parkin-mediated Ubiquitination Regulates Phospholipase C-gamma1.
Phosphatidylinositol 4,5-bisphosphate modifies tubulin participation in phospholipase Cbeta1 signaling.
Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.
Regulation of muscarinic agonist-induced activation of phosphoinositidase C in electrically permeabilized SH-SY5Y human neuroblastoma cells by guanine nucleotides.
Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.
Neurodegenerative Diseases
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Location-dependent role of phospholipase C signaling in the brain: Physiology and pathology.
Osteolysis
Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells.
Osteosarcoma
Evidence for phosphatidylinositol-linked forms of human and avian fibronectin receptors.
Expression of Phosphoinositide-specific phospholipase C enzymes in human osteosarcoma cell lines.
Ezrin silencing remodulates the expression of Phosphoinositide-specific Phospholipase C enzymes in human osteosarcoma cell lines.
Ezrin-related Phosphoinositide pathway modifies RhoA and Rac1 in human osteosarcoma cell lines.
G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes.
Phosphoinositide-specific phospholipase C isoforms are conveyed by osteosarcoma-derived extracellular vesicles.
Release of alkaline phosphatase from human osteosarcoma cells by phosphatidylinositol phospholipase C: effect of tunicamycin.
Silencing of phosphoinositide-specific phospholipase C ? remodulates the expression of the phosphoinositide signal transduction pathway in human osteosarcoma cell lines.
Ovarian Neoplasms
Membrane association and shedding of the GPI-anchored Ca-MOv18 antigen in human ovary carcinoma cells.
Molecular nature and possible presence of a membranous glycan-phosphatidylinositol anchor of CA125 antigen.
Paralysis
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Parkinson Disease
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Pemphigus
Phosphatidylinositol-specific-phospholipase C cleaves urokinase plasminogen activator receptor from the cell surface and leads to inhibition of pemphigus-IgG-induced acantholysis in DJM-1 cells, a squamous cell carcinoma line.
Pheochromocytoma
Discrete subcellular localization of phosphoinositidase C beta, gamma and delta in PC12 rat pheochromocytoma cells.
Hydrogen peroxide induces the activation of the phospholipase C-gamma1 survival pathway in PC12 cells: protective role in apoptosis.
Immunocytochemical analysis of phosphatidylinositol-specific phospholipase C in PC12 cells: predominance of the delta isoform during neural differentiation.
Nerve growth factor stimulates the tyrosine phosphorylation of a 38-kDa protein that specifically associates with the src homology domain of phospholipase C-gamma 1.
Phosphatidylinositol-anchored glycoproteins of PC12 pheochromocytoma cells and brain.
phosphatidylinositol 3-kinase deficiency
Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction.
phosphoinositide phospholipase c deficiency
A network analysis of changes in molecular interactions in cellular signaling.
Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.
Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction.
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.
Lineage-specific defect in gene expression in human platelet phospholipase C-beta2 deficiency.
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.
Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells.
Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R.
Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors.
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.
Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells.
Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance.
Phospholipase C{gamma}2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis.
The role of glycosylphosphatidylinositol phospholipase C in membrane trafficking in Trypanosoma brucei.
Pick Disease of the Brain
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Pneumonia
NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues.
Prostatic Neoplasms
Caveolin-1 regulates VEGF-stimulated angiogenic activities in prostate cancer and endothelial cells.
Changes in choline metabolism as potential biomarkers of phospholipase C{gamma}1 inhibition in human prostate cancer cells.
Expression and function of the complement membrane attack complex inhibitor protectin (CD59) in human prostate cancer.
OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells.
Protein Deficiency
Expression of T lymphocyte p56(lck), a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice.
Protein-Energy Malnutrition
Expression of T lymphocyte p56(lck), a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice.
Proteinuria
Non-immunologic mechanisms of calcineurin inhibitors explain its antiproteinuric effects in genetic glomerulopathies.
Reperfusion Injury
Alteration of phosphoinositide degradation by cytosolic and membrane-bound phospholipases after forebrain ischemia-reperfusion in gerbil: effects of amyloid beta peptide.
Respiratory Distress Syndrome
Phosphatidylinositol-specific phospholipase C, a possible virulence factor of Staphylococcus aureus.
Retinal Degeneration
Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila.
cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).
Limited role of developmental programmed cell death pathways in Drosophila norpA retinal degeneration.
Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2.
Retinoblastoma
Lipase inactive mutant of PLC-gamma1 regulates NGF-induced neurite outgrowth via enzymatic activity and regulation of cell cycle regulatory proteins.
Sarcoma, Avian
Phospholipase C-gamma 1 associates with viral and cellular src kinases.
Sequence similarity of phospholipase C with the non-catalytic region of src.
Sarcoma, Ewing
Preferential down-regulation of phospholipase C-beta in Ewing's sarcoma cells transfected with antisense EWS-Fli-1.
Scrapie
Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C.
Seizures
Deletion of phospholipase C beta4 in thalamocortical relay nucleus leads to absence seizures.
Sepsis
Disruption of phospholipase C{gamma}1 signalling attenuates cardiac tumor necrosis factor-{alpha} expression and improves myocardial function during endotoxemia.
The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism.
Shock, Septic
Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes.
Phosphatidylinositol-specific phospholipase C, a possible virulence factor of Staphylococcus aureus.
Skin Diseases
Phosphatidylinositol-specific phospholipase C enhances epidermal penetration by Staphylococcus aureus.
Small Cell Lung Carcinoma
Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma.
Spasm
Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm.
Squamous Cell Carcinoma of Head and Neck
HIF2{alpha}-mediated activation of the Epidermal Growth Factor Receptor potentiates head and neck cancer cell migration in response to hypoxia.
Status Epilepticus
mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.
Stomach Neoplasms
Association of Potentially Functional Genetic Variants of PLCE1 with Gallbladder Cancer Susceptibility in North Indian Population.
Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer.
Genetic polymorphism of the phospholipase C epsilon 1 gene and risk of gastric cancer.
Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley.
PLC?1: a potential target of RNA interference therapy for gastric cancer.
PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population.
Roles of PLC-gamma2 and PKCalpha in TPA-induced apoptosis of gastric cancer cells.
The Correlation between Phospholipase C Epsilon (PLCE1) Gene Polymorphisms and Risk of Gastric Adenocarcinoma in Iranian Population.
Stroke
Clinical Features and Related Factors of Poststroke Pathological Laughing and Crying: A Case-Control Study.
Subarachnoid Hemorrhage
Analysis of phospholipase C gene in patients with subarachnoid hemorrhage due to ruptured intracranial saccular aneurysm.
Phospholipase C activity in cerebrospinal fluid following subarachnoid hemorrhage related to brain damage.
Supranuclear Palsy, Progressive
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Tabes Dorsalis
Phospholipase cbeta4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum.
Roles of phospholipase Cbeta4 in synapse elimination and plasticity in developing and mature cerebellum.
Tangier Disease
Growth and cell cycle abnormalities of fibroblasts from Tangier disease patients.
Teratocarcinoma
Reduced expression of PLC-gamma during the differentiation of mouse F9 teratocarcinoma cells.
Teratozoospermia
Reduced fertilization after ICSI and abnormal phospholipase C zeta presence in spermatozoa from the wobbler mouse.
Reproductive outcome in globozoospermic men: update and prospects.
Subcellular localization of phospholipase C? in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation.
thioredoxin-dependent peroxiredoxin deficiency
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II.
Thrombosis
Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo.
Dual role of collagen in factor XII-dependent thrombus formation.
Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.
Importance of platelet phospholipase Cgamma2 signaling in arterial thrombosis as a function of lesion severity.
Phospholipase Cgamma2 contributes to stable thrombus formation on VWF.
Rac1 is essential for phospholipase C-gamma2 activation in platelets.
Thymoma
Removal of lymphocyte surface molecules with phosphatidylinositol-specific phospholipase C: effects on mitogen responses and evidence that ThB and certain Qa antigens are membrane-anchored via phosphatidylinositol.
Trypanosomiasis, African
Glycosylphosphatidylinositol-specific phospholipase C regulates transferrin endocytosis in the African trypanosome.
Urinary Bladder Neoplasms
Knockdown of Phospholipase C-Epsilon by Short-Hairpin RNA-Mediated Gene Silencing Induces Apoptosis in Human Bladder Cancer Cell Lines.
Vaccinia
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
Molecular cloning, splice variants, expression, and purification of phospholipase C-delta 4.
Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity.
Tyrosine phosphorylation of phospholipase C-gamma 1 by vaccinia virus growth factor.
Vascular System Injuries
Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2.
Rac1 is essential for phospholipase C-gamma2 activation in platelets.
Virus Diseases
Delineation of the essential function of bovine herpesvirus 1 gD: an indication for the modulatory role of gD in virus entry.
Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors.
Tec Kinases Itk and Rlk Are Required for CD8+ T Cell Responses to Virus Infection Independent of Their Role in CD4+ T Cell Help.
Whooping Cough
1alpha,25(OH)2D3 causes a rapid increase in phosphatidylinositol-specific PLC-beta activity via phospholipase A2-dependent production of lysophospholipid.
Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor.
Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses.
Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia.
Bradykinin modulates potassium and calcium currents in neuroblastoma hybrid cells via different pertussis toxin-insensitive pathways.
Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C.
Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts.
Characterization of phosphatidylinositol-specific phospholipase C (PI-PLC) from Lilium daviddi pollen.
Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor.
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C.
Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2.
Effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and DNA synthesis in Swiss 3T3 cells.
Epidermal growth factor activates phospholipase C in rat hepatocytes via a different mechanism from that in A431 or rat1hER cells.
Epidermal growth factor activates phospholipase C-gamma 1 via G(i)1-2 proteins in isolated pancreatic acinar membranes.
Epidermal growth factor-induced activation and translocation of phospholipase C-gamma 1 to the cytoskeleton in rat hepatocytes.
Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity.
Extracellular ATP augments mesangial cell growth induced by multiple growth factors.
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
Galpha(q/11) and gbetagamma proteins and membrane signaling of calcitriol and estradiol.
Ghrelin signalling in guinea-pig femoral artery smooth muscle cells.
Growth hormone inhibits activation of phosphatidylinositol phospholipase C in adipose plasma membranes: evidence for a growth hormone-induced change in G protein function.
Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages.
Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits.
Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor signals through multiple pathways in endothelial cells.
Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle.
Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells.
Membrane signaling and progesterone in female and male osteoblasts. II. Direct involvement of G alpha q/11 coupled to PLC-beta 1 and PLC-beta 3.
Muscarinic M3 receptor coupling and regulation.
Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle.
Pancreastatin activates beta3 isoform of phospholipase C via G(alpha)11 protein stimulation in rat liver membranes.
Pertussis toxin stimulates cholecystokinin-induced cyclic AMP formation but is without effect on secretagogue-induced calcium mobilization in exocrine pancreas.
Pertussis toxin-sensitive activation of phospholipase A2 can be resolved from phosphoinositidase C in primary cultures of mouse osteoblasts using indomethacin.
Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes.
Phospholipase C beta and membrane action of calcitriol and estradiol.
Platelet-activating factor (PAF) stimulates phosphatidylinositol hydrolysis in human peripheral blood mononuclear leukocytes.
Platelet-activating factor-induced phosphoinositide metabolism in differentiated U-937 cells in culture.
Possible involvement of phosphatidylinositol-specific phospholipase C related to pertussis toxin-sensitive GTP-binding proteins during adipocyte differentiation of 3T3-L1 fibroblasts: negative regulation of protein kinase C.
Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme.
Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells.
Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction.
Role of G proteins in activation of phosphoinositide phospholipase C.
Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein.
Signaling networks from Gbeta1 subunit to transcription factors and actin remodeling via a membrane-located ERbeta-related protein in the rapid action of daidzein in osteoblasts.
Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation.
Studies on the mechanisms of signalling and inhibition by pertussis toxin of fibroblast growth factor-stimulated mitogenesis in Balb/c 3T3 cells.
Synergistic activation of phospholipases Cgamma and Cbeta: A novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release.
The role of G protein methylation in the function of a geranylgeranylated beta gamma isoform.
Transfected m2 muscarinic acetylcholine receptors couple to G alpha i2 and G alpha i3 in Chinese hamster ovary cells. Activation and desensitization of the phospholipase C signaling pathway.
Transmembrane signalling pathways initiating cell growth in fibroblasts.
[Phospholipid metabolism regulated by heterotrimeric G proteins]
Wilms Tumor
Cyclosporine A responsive congenital nephrotic syndrome with single heterozygous variants in NPHS1, NPHS2, and PLCE1.
Wiskott-Aldrich Syndrome
Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains.