Information on EC 3.1.3.96 - pseudouridine 5'-phosphatase

for references in articles please use BRENDA:EC3.1.3.96
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The expected taxonomic range for this enzyme is: Homo sapiens

EC NUMBER
COMMENTARY hide
3.1.3.96
-
RECOMMENDED NAME
GeneOntology No.
pseudouridine 5'-phosphatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate
show the reaction diagram
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
pseudouridine 5'-phosphohydrolase
Requires Mg2+ for activity.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
X-linked ichthyosis patients harbour a combined deletion of the STS gene (the X-linked ichthyosis gene) and the HDHD1 gene
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
pseudouridine 5'-phosphate + H2O
pseudouridine + phosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
pseudouridine 5'-phosphate + H2O
pseudouridine + phosphate
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
required for activity
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
-
-
pseudouridine
-
-
vanadate
-
-
additional information
-
not inhibited by 5'-UMP at a concentration of 0.3 mM, 1-methylpseudouridine barely inhibits, no inhibition with uridine and adenosine
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00038
pseudouridine 5'-phosphate
-
pH 7.1, 30°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.6
pseudouridine 5'-phosphate
-
pH 7.1, 30°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4184
pseudouridine 5'-phosphate
-
pH 7.1, 30°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.1
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
pseudouridine-5'-phosphatase activity is 1.5-fold higher in erythrocytes from women compared with men
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
26000
-
gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
-