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Information on EC 3.1.3.78 - phosphatidylinositol-4,5-bisphosphate 4-phosphatase

for references in articles please use BRENDA:EC3.1.3.78
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IUBMB Comments
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] . One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P . In humans, the enzyme is localized to late endosomal/lysosomal membranes . It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis .
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
IpgD, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, phosphoinositide phosphatase, PtdIns(4,5)P2 4-phosphatase, PtdIns-4,5-P2 4-phosphatase type I, PtdIns-4,5-P2 4-phosphatase type II, SigD, type I 4-phosphatase, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
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