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Information on EC 3.1.3.67 - phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

for references in articles please use BRENDA:EC3.1.3.67
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EC Tree
IUBMB Comments
Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
phosphatase and tensin homolog, phosphatase and tensin homologue, pten/mmac1, pten phosphatase, voltage-sensing phosphatase, pten/mmac, pi 3-phosphatase, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, mmac1/tep1, voltage-sensing phosphoinositide phosphatase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate
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PATHWAY SOURCE
PATHWAYS
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