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Information on EC 3.1.3.62 - multiple inositol-polyphosphate phosphatase
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3.1.3.62 multiple inositol-polyphosphate phosphataseIUBMB Comments
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
multiple inositol-polyphosphate phosphatase, (mmu)minpp1, (hsa)minpp1, taphyiia2, taphyiib, hvphyiib, hvphyiia2, inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1D-myo-inositol-1,3,4,5-tetrakisphosphate 3-phosphohydrolase
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inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
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inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase
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inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase
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inositol tetrakisphosphate phosphomonoesterase
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inositol-1,3,4,5-tetrakisphosphate 3-phosphatase
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Minpp
MIPP
multiple inositol polyphosphate phosphatase
phosphatase, inositol 1,3,4,5-tetrakisphosphate 3-
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additional information
Minpp
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MIPP
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multiple inositol polyphosphate phosphatase
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additional information
distinct group within the histidine phosphatase family
additional information
structural and functional relationship between MIPP and histidine acid phosphatase
additional information
distinct group within the histidine phosphatase family
additional information
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structural and functional relationship between MIPP and histidine acid phosphatase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate
formerly D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + phosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
hydrolysis of phosphoric ester
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
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CAS REGISTRY NUMBER
COMMENTARY
116958-30-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + H2O
D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate
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-
-
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
inositol 3,4,5,6-tetrakisphosphate + H2O
?
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about 10% of activity with inositol 1,3,4,5-tetrakisphosphate
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?
myo-inositol hexakisphosphate + H2O
myo-inositol pentakisphosphate + phosphate
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?
scyllo-inositol hexakisphosphate + H2O
scyllo-inositol pentakisphosphate + phosphate
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?
2,3-bisphosphoglycerate + H2O
2-phosphoglycerate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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-
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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-
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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-
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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recombinant N-terminal truncated cytosolic MIPP generates inositol 1,4,5-trisphosphate in an intact cell
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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enzyme may be regulated by the intracellular concentrations of inositol tris- and tetrakisphosphates
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?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
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?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
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?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
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?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
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?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
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?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
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?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
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recombinant N-terminal truncated cytosolic MIPP
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?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
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inositol pentakisphosphate and inositol hexakisphosphate are likely to be the preferred substrates in vivo
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?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
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?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
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?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
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?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
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?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
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?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
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at least 4 isomers: D- and/or L-inositol 1,2,4,5,6-pentakisphosphate, D-inositol 1,3,4,5,6-pentakisphosphate, D-inositol 1,2,3,4,6-pentakisphosphate and D- and/or L-inositol 1,2,3,4,5-pentakisphosphate
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
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recombinant N-terminal truncated cytosolic MIPP
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?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
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inositol pentakisphosphate and inositol hexakisphosphate are likely to be the preferred substrates in vivo
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?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
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?
additional information
?
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catalytic requirement for the C-terminus and His-370 of MIPP
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?
additional information
?
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dephosphorylates inositol signaling molecules InsP5 and InsP6
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?
additional information
?
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Minpp is important to chondrocyte differentiation in a manner independent of inositol polyphosphate turnover
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?
additional information
?
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dephosphorylates inositol signaling molecules InsP5 and InsP6
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?
additional information
?
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dephosphorylates inositol signaling molecules InsP5 and InsP6
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?
additional information
?
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not: inositol 1,3,4-trisphosphate, inositol 1,3-bisphosphate, inositol 3,4-bisphosphate, 4-nitrophenyl phosphate
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?
additional information
?
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enzyme is relatively unimportant to inositol 1,3,4,5-tetrakisphosphate metabolism in vivo
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?
additional information
?
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MIPP mRNA is upregulated during chondrocyte hypertrophy, MIPP may aid bone mineralization and salvage the inositol moiety prior to apoptosis
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?
additional information
?
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inositol 1,3,4,5-tetrakisphosphate 3-phosphatase is unlikely to be an important activity in vivo
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?
additional information
?
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function is unrelated to the metabolism of Ca2+-mobilizing cellular signals
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?
additional information
?
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role in the metabolism of inositol phosphates, but probably no important participant in signal transduction
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
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enzyme may be regulated by the intracellular concentrations of inositol tris- and tetrakisphosphates
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?
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
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inositol pentakisphosphate and inositol hexakisphosphate are likely to be the preferred substrates in vivo
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?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
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inositol pentakisphosphate and inositol hexakisphosphate are likely to be the preferred substrates in vivo
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?
additional information
?
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Minpp is important to chondrocyte differentiation in a manner independent of inositol polyphosphate turnover
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?
additional information
?
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enzyme is relatively unimportant to inositol 1,3,4,5-tetrakisphosphate metabolism in vivo
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?
additional information
?
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MIPP mRNA is upregulated during chondrocyte hypertrophy, MIPP may aid bone mineralization and salvage the inositol moiety prior to apoptosis
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?
additional information
?
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inositol 1,3,4,5-tetrakisphosphate 3-phosphatase is unlikely to be an important activity in vivo
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?
additional information
?
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function is unrelated to the metabolism of Ca2+-mobilizing cellular signals
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?
additional information
?
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role in the metabolism of inositol phosphates, but probably no important participant in signal transduction
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?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
additional information
Mg2+
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2.5fold activation at 5-10 mM, no activation at 1 mM and physiologically relevant concentrations
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ammonium phosphate buffer
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1 to 10 mM activates, higher concentrations are inhibitory
Endogenous heat-stable inhibitor
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from soluble and particulate regions of liver cells
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Inositol 1,3,4,5,6-pentakisphosphate
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0.001 mM, 50% inhibition; competitive; strong, kinetics
Inositol 1,3,4,5,6-pentakisphosphate
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competitive; strong, kinetics; turkey hemoglobin reverses
inositol 3,4,5,6-tetrakisphosphate
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commercially available with 12% inositol 2,4,5,6-tetrakisphosphate, from turkey erythrocytes, marked inhibition, linear mixed-type inhibition
Inositol hexakisphosphate
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mixed inhibitor, 0.001 mM, 85% inhibition; more effective than inositol pentakisphosphate; strong, kinetics
Inositol hexakisphosphate
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competitive, turkey hemoglobin reverses; more effective than inositol pentakisphosphate; strong, kinetics
Inositol hexakisphosphate
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more effective than inositol pentakisphosphate; strong, kinetics
additional information
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extracts of liver, heart, kidney, testis and brain contain different amounts of endogenous inhibitors of enzyme activity
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additional information
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not inhibited by Mg2+, Ca2+, Li+, non-hydrolysable adenine, guanine nucleotides or deoxynucleotides
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ammonium phosphate buffer
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1 to 10 mM activates, higher concentrations are inhibitory
hemoglobin
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from turkey, activates by removing the inhibitors inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Colonic Neoplasms
Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia.
Neoplasms
Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19.
Neoplasms
Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
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kinetic data of the cytosolic enzyme
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0.007 - 0.008
D-myo-Inositol 1,3,4,5-tetrakisphosphate
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pH 7.2, 37°C, cytosolic enzyme
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
activity of MINPP towards other phosphates, relative to inositol hexakisphosphate, is as follows: p-nitrophenyl phosphate: 17%, ATP: 11%, D-ribose 1-phosphate: 0.31%
additional information
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Q78A mutant shows differences in its specificity profile compared to wild-type enzyme: relative to inositol hexakisphosphate, the activity towards other phosphates are as follows: p-nitrophenyl phosphate: 7%, ATP: 12%, D-ribose 1-phosphate: 3%
additional information
expression of HvPhyIIb in Escherichia coli reveals that the MINPPs possesses a significant phytase activity with narrow substrate specificity for phytate
additional information
expression of HvPhyIIb in Escherichia coli reveals that the MINPPs possesses a significant phytase activity with narrow substrate specificity for phytate
additional information
expression of HvPhyIIb in Escherichia coli reveals that the MINPPs possesses a significant phytase activity with narrow substrate specificity for phytate
additional information
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expression of HvPhyIIb in Escherichia coli reveals that the MINPPs possesses a significant phytase activity with narrow substrate specificity for phytate
additional information
expression of TaPhyIIa2 in Escherichia coli reveals that the MINPPs possesses a significant phytase activity with narrow substrate specificity for phytate
additional information
expression of TaPhyIIa2 in Escherichia coli reveals that the MINPPs possesses a significant phytase activity with narrow substrate specificity for phytate
additional information
expression of TaPhyIIa2 in Escherichia coli reveals that the MINPPs possesses a significant phytase activity with narrow substrate specificity for phytate
additional information
expression of TaPhyIIa2 in Escherichia coli reveals that the MINPPs possesses a significant phytase activity with narrow substrate specificity for phytate
additional information
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expression of TaPhyIIa2 in Escherichia coli reveals that the MINPPs possesses a significant phytase activity with narrow substrate specificity for phytate
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4.5
5 - 9
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plateau within the range, inositol 1,3,4,5,6-pentakisphosphate or inositol hexakisphosphate as substrate, in absence of Mg2+
7.4
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
65
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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chondrocyte progenitor cell line, developmentally specific changes in MINPP expression
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