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Information on EC 3.1.3.50 - sorbitol-6-phosphatase

for references in articles please use BRENDA:EC3.1.3.50

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EC Tree

3 Hydrolases

3.1 Acting on ester bonds

3.1.3 Phosphoric-monoester hydrolases

3.1.3.50 sorbitol-6-phosphatase

IUBMB Comments

Acts, very slowly, on hexose 6-phosphates.

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Reaction Schemes

Synonyms

sorbitol-6-phosphatase, show all synonyms

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

HAD1

HAD2

phosphatase, sorbitol 6-

sorbitol-6-phosphate phosphatase

YfbT

YniC

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

sorbitol 6-phosphate + H2O = sorbitol + phosphate

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

hydrolysis of phosphoric ester

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Go to Pathway Search

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PATHWAY SOURCE

PATHWAYS

MetaCyc

D-sorbitol biosynthesis I

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Go to Systematic Name Search

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SYSTEMATIC NAME

IUBMB Comments

sorbitol-6-phosphate phosphohydrolase

Acts, very slowly, on hexose 6-phosphates.

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CAS REGISTRY NUMBER

COMMENTARY

80449-21-4

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

D-sorbitol 6-phosphate + H2O

D-sorbitol + phosphate

2 entries

sorbitol 6-phosphate + H2O

sorbitol + phosphate

Malus domestica

81101

additional information

Malus domestica

no substrate: other phosphate esters than sorbitol-6-phosphate

653560

D-sorbitol 6-phosphate + H2O

D-sorbitol + phosphate

Escherichia coli

751241

D-sorbitol 6-phosphate + H2O

D-sorbitol + phosphate

Malus domestica

highly specific

653560

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

sorbitol 6-phosphate + H2O

sorbitol + phosphate

Malus domestica

81101

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METALS and IONS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Mg2+

Malus domestica

required

653560

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

fluoride

molybdate

phosphate

sorbitol

competitive

vanadate

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

20-hydroxyecdysone

Bombyx mori

668943

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.8 - 3.9

D-sorbitol 6-phosphate

2 entries

0.85

D-sorbitol-6-phosphate

Malus domestica

pH 6.8, 30Â°C

653560

1.8

D-sorbitol 6-phosphate

Escherichia coli

pH 7.0, 30Â°C

751241

3.9

D-sorbitol 6-phosphate

Escherichia coli

pH 7.0, 30Â°C

751241

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

21 - 63

D-sorbitol 6-phosphate

2 entries

D-sorbitol 6-phosphate

Escherichia coli

pH 7.0, 30Â°C

751241

D-sorbitol 6-phosphate

Escherichia coli

pH 7.0, 30Â°C

751241

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

12 - 16

D-sorbitol 6-phosphate

2 entries

D-sorbitol 6-phosphate

Escherichia coli

pH 7.0, 30Â°C

751241

D-sorbitol 6-phosphate

Escherichia coli

pH 7.0, 30Â°C

751241

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

109

D-sorbitol

Malus domestica

pH 6.8, 30Â°C

653560

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

89.8

Malus domestica

pH 6.8, 30Â°C

653560

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5.5

6.8

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

brenda

brenda

brenda

apple

brenda

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

fat body

Bombyx mori

low activity during feeding period, abrupt increase in activity during wandering, and decrease to low level after gut purge

brenda

of larva

brenda

hemolymph from larva

brenda

brenda

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LOCALIZATION

ORGANISM

UNIPROT

COMMENTARY

GeneOntology No.

LITERATURE

SOURCE

association with

brenda

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

P77625 pBLAST

HXPA_ECOLI

Escherichia coli (strain K12)

216

23008

Swiss-Prot

Show Sequence

Q7ADF8 pBLAST

HXPB_ECO57

Escherichia coli O157:H7

222

24329

Swiss-Prot

Show Sequence

P77247 pBLAST

HXPB_ECOLI

Escherichia coli (strain K12)

222

24330

Swiss-Prot

Show Sequence

Q9P6N2 pBLAST

PTF1_SCHPO

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

229

26272

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

P53981 pBLAST

PYP1_YEAST

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

241

27481

Swiss-Prot

Show Sequence

other Location (Reliability: 2)

A0A8A8FSQ5 pBLAST

A0A8A8FSQ5_9GAMM

Erwinia gerundensis

222

24628

TrEMBL

Show Sequence

A0A8A7I4I2 pBLAST

A0A8A7I4I2_KLEPN

Klebsiella pneumoniae

222

24490

TrEMBL

Show Sequence

A0A8A9FEM7 pBLAST

A0A8A9FEM7_PROMI

Proteus mirabilis

222

24459

TrEMBL

Show Sequence

A0A8A6IZ76 pBLAST

A0A8A6IZ76_SERMA

Serratia marcescens subsp. marcescens ATCC 13880

221

24967

TrEMBL

Show Sequence

A0A8B1C8T2 pBLAST

A0A8B1C8T2_ECOLX

Escherichia coli O128ac:H12

222

24330

TrEMBL

Show Sequence

A0A5B8QU41 pBLAST

A0A5B8QU41_9GAMM

Shewanella decolorationis

217

24013

TrEMBL

Show Sequence

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

61000

Malus domestica

gel filtration

653560

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SUBUNIT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

x * 24300, SDS-PAGE

monomer

1 * 61000, SDS-PAGE

Go to Purification (commentary) Search

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

partial

Go to Cloned (commentary) Search

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expression in Escherichia coli

Escherichia coli

751241

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

81101

Grant, C.R.; Rees, T.A.

Sorbitol metabolism by apple seedlings

Phytochemistry

1505-1511

1981

Malus domestica

brenda

653560

Zhou, R.; Cheng, L.; Wayne, R.

Purification and characterization of sorbitol-6-phosphate phosphatase from apple leaves

Plant Sci.

165

227-232

2003

Malus domestica

brenda

668943

Oda, Y.; Iwami, M.; Sakurai, S.

Membrane-bound sorbitol 6-phosphatase in fat body cells controls the dynamics of sorbitol 6-phosphate, a major hemolymph sugar in the silkworm

Insect Biochem. Mol. Biol.

1284-1292

2005

Bombyx mori

16203209

brenda

751241

Chin, T.; Ikeuchi, M.

Detection of active sorbitol-6-phosphate phosphatase in the haloacid dehalogenase-like hydrolase superfamily

J. Gen. Appl. Microbiol.

248-252

2018

Escherichia coli

29743459

brenda

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EXTERNAL LINKS (specific for EC-Number 3.1.3.50)

ExplorEnz (official portal for IUBMB Enzyme Nomenclature)

Expasy Enzyme Nomenclature Database

KEGG

MetaCyc

SABIO-RK

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

Enzyme Nomenclature (alternative site)

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)