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Information on EC 3.1.3.48 - protein-tyrosine-phosphatase
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EC Tree
3.1.3.48 protein-tyrosine-phosphataseIUBMB Comments
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
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Word Map
- 3.1.3.48
-
herpes
- simplex
- plasmin
- autoimmune
- t-cells
- metastasis
- urokinase
- fibrin
-
signal-regulated
-
okadaic
-
tissue-type
-
checkpoint
- vanadate
- phosphatidylinositol
- myeloid
- obesity
-
fibrinogen
-
3-kinase
-
adaptor
- arthritis
-
tyrosine-phosphorylated
-
cyclin-dependent
-
fibrinolysis
- mellitus
- thrombin
-
rheumatoid
-
hyperphosphorylation
- upa
-
metalloproteinase
-
streptokinase
- clot
-
autophosphorylation
- genistein
-
integrins
-
urokinase-type
-
receptor-like
- thrombosis
-
platelet-derived
-
genital
-
insulin-stimulated
-
thrombolytic
-
phosphopeptide
-
inhibitor-1
- chondroitin
-
janus
-
myelomonocytic
- acyclovir
-
paxillin
-
substrate-1
-
polo-like
- medicine
- pharmacology
- drug development
The enzyme appears in viruses and cellular organisms
Synonyms
ptp1b, protein tyrosine phosphatase, shp-1, shp-2, tyrosine phosphatase, mkp-1, protein phosphatase 2a, cdc25a, ptpn22, cdc25c, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
70Z-SHP
-
-
-
-
acid phosphatase ortholog
-
the enzyme share the conserved RHGXRXP motif characteristic of the histidine acid phosphatase family
Bd1204
Brain-derived phosphatase
-
-
-
-
BVP
-
-
-
-
CAPTPase
CD148 antigen
-
-
-
-
CD45
CD45 antigen
-
-
-
-
CD45 protein tyrosine phosphatase
Cdc25-like protein
-
-
-
-
Cdc25A
Cdc25B
Cdc25C
CDK2-associated dual specificity phosphatase
-
-
-
-
Ch-1PTPase
-
-
-
-
CPTP1
-
-
-
-
Cryp-2
cysteine-dependent protein tyrosine phosphatase
DEP-1
DLAR
-
-
-
-
dPTP61F
-
dPTP61F plays a central role in counteracting PTK-mediated signaling pathways as well as in regulating actin reorganization and remodeling through tyrosine dephosphorylation of critical substrates in Drosophila
dual specificity phosphatase
Dual specificity phosphatase Cdc25A
-
-
-
-
Dual specificity phosphatase Cdc25B
-
-
-
-
Dual specificity phosphatase Cdc25C
-
-
-
-
Dual specificity protein phosphatase hVH1
-
-
-
-
Dual specificity protein phosphatase hVH2
-
-
-
-
Dual specificity protein phosphatase hVH3
-
-
-
-
Dual specificity protein phosphatase PYST1
-
-
-
-
Dual specificity protein phosphatase PYST2
-
-
-
-
Dual specificity protein phosphatase VHR
-
-
-
-
Dual-specificity tyrosine phosphatase TS-DSP6
-
-
-
-
Dual-specificity tyrosine phosphatase YVH1
-
-
-
-
ES cell phosphatase
-
-
-
-
HCP
-
-
-
-
HD-PTP
Hematopoietic cell protein-tyrosine phosphatase
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
-
-
-
-
Hematopoietic protein-tyrosine phosphatase
-
-
-
-
HEPTP
HPTP beta-like tyrosine phosphatase
-
-
-
-
HPTP eta
-
-
-
-
hPTPE1
-
-
-
-
ICAAR
-
-
-
-
Islet cell autoantigen related protein
-
-
-
-
kinase associated phosphatase
-
-
-
-
L-CA
-
-
-
-
LAR
Late protein H1
-
-
-
-
LCA
-
-
-
-
LCA-related phosphatase
-
-
-
-
leucocyte common antigen-related protein tyrosine phosphatase
Leukocyte antigen related
-
-
-
-
LMW-PTP
Low molecular weight cytosolic acid phosphatase
-
-
-
-
low molecular weight protein tyrosine phosphatase
low-molecular-weight protein tyrosine phosphatase
LRP
-
-
-
-
Lymphoid phosphatase
-
-
-
-
LyP
M1851
-
-
-
-
MAP-kinase phosphatase CPG21
-
-
-
-
MEG
-
-
-
-
mitogen-activated protein kinase-specific tyrosine phosphatase
-
Mitosis initiation protein
-
-
-
-
Mitosis initiation protein MIH1
-
-
-
-
Mitotic inducer homolog
-
-
-
-
MKP-1 like protein tyrosine phosphatase
-
-
-
-
MKP-3
MKP-4
MKP-5
MPTP
-
-
-
-
MPTP-PEST
-
-
-
-
MPtpA
NC-PTPCOM1
-
-
-
-
Neural-specific protein-tyrosine phosphatase
-
-
-
-
non-receptor protein tyrosine phosphatase
ORF5
-
-
-
-
OST-PTP
P19-PTP
-
-
-
-
P80
-
-
-
-
PC12-PTP1
-
-
-
-
Phogrin
-
-
-
-
Phosphacan
-
-
-
-
phosphatase, phosphoprotein (phosphotyrosine)
-
-
-
-
phosphatase, phosphotyrosine
-
-
-
-
phosphoprotein phosphatase (phosphotyrosine)
-
-
-
-
phosphotyrosine histone phosphatase
-
-
-
-
phosphotyrosine phosphatase
-
-
-
-
Phosphotyrosine phosphatase 13
-
-
-
-
phosphotyrosine protein phosphatase
-
-
-
-
phosphotyrosylprotein phosphatase
-
-
-
-
Pmp1p
PPM
-
the recombinant protein exhibits protein-tyrosine phosphatase in addition to its predicted protein-serine/threonine phosphatase activity
protein phosphotyrosine phosphatase
-
-
-
-
protein tyrosine phosphatase
protein tyrosine phosphatase 1B
protein tyrosine phosphatase-1B
Protein tyrosine phosphatase-NP
-
-
-
-
Protein-protein-tyrosine phosphatase HA2
-
-
-
-
protein-tyrosine phosphatase
Protein-tyrosine phosphatase 1B
Protein-tyrosine phosphatase 1C
-
-
-
-
Protein-tyrosine phosphatase 1E
-
-
-
-
Protein-tyrosine phosphatase 2C
-
-
-
-
Protein-tyrosine phosphatase 2E
-
-
-
-
Protein-tyrosine phosphatase 3CH134
-
-
-
-
Protein-tyrosine phosphatase CL100
-
-
-
-
Protein-tyrosine phosphatase D1
Protein-tyrosine phosphatase ERP
-
-
-
-
Protein-tyrosine phosphatase G1
-
-
-
-
Protein-tyrosine phosphatase H1
-
-
-
-
Protein-tyrosine phosphatase LC-PTP
-
-
-
-
Protein-tyrosine phosphatase MEG1
-
-
-
-
Protein-tyrosine phosphatase MEG2
-
-
-
-
Protein-tyrosine phosphatase P19
-
-
-
-
Protein-tyrosine phosphatase PCPTP1
-
-
-
-
Protein-tyrosine phosphatase pez
-
-
-
-
Protein-tyrosine phosphatase PTP-RL10
-
-
-
-
Protein-tyrosine phosphatase PTP36
-
-
-
-
Protein-tyrosine phosphatase PTPL1
-
-
-
-
Protein-tyrosine phosphatase striatum-enriched
-
-
-
-
Protein-tyrosine phosphatase SYP
-
-
-
-
Protein-tyrosine-phosphatase SL
-
-
-
-
Protein-tyrosine-phosphate phosphohydrolase
-
-
-
-
PTEN
PTK
PTP
PTP IA-2beta
-
-
-
-
PTP-1B
PTP-1C
-
-
-
-
PTP-1D
-
-
-
-
PTP-2C
-
-
-
-
PTP-BAS
PTP-E1
-
-
-
-
PTP-H1
-
-
-
-
PTP-HA2
-
-
-
-
PTP-like phytase
PTP-MEG2
PTP-NP
-
-
-
-
PTP-oc
-
the protein is produced from the distal promotor, PTP-oc is identical to PTPRO, except that its extracellular domain is extremely short with eight amino acids in all
PTP-PEST
PTP-SH2beta
-
-
-
-
PTP1
PTP1B
PTP1C
-
-
-
-
PTP1D
-
-
-
-
PTP2C
-
-
-
-
PTP36
PtpA
PTPalpha
PTPase
PTPase YVH1
-
-
-
-
PTPase-MEG1
PTPase-MEG2
PtpB
PTPB1
PTPBR7
PTPD1
PTPepsilon
PTPG1
-
-
-
-
PTPH1
PTPLP
PTPN1
PTPN11
PTPN12
PTPN22
PTPN23
PTPN4
PTPN5
PTPN6
PTPN7
PTPN9
PTPNE6
-
-
-
-
PTPRJ
PTPRO
PTPRR
PTPRT
PY protein phosphatase
-
-
-
-
Pyp1p
Pyp2p
R-PTP-alpha
-
-
-
-
R-PTP-beta
-
-
-
-
R-PTP-delta
-
-
-
-
R-PTP-epsilon
-
-
-
-
R-PTP-eta
-
-
-
-
R-PTP-gamma
-
-
-
-
R-PTP-kappa
-
-
-
-
R-PTP-mu
-
-
-
-
R-PTP-zeta
-
-
-
-
R2B phosphatase
receptor protein tyrosine phosphatase rho
Receptor-linked protein-tyrosine phosphatase 10D
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 99A
-
-
-
-
RNA/RNP complex-intereracting phosphatase
-
-
-
-
ROL B protein
-
-
-
-
RPTPalpha
RPTPepsilon
RPTPkappa
RPTPrho/PTPRT
Saci-PTP
Saci0545
SH-PTP1
-
-
-
-
SH-PTP2
-
-
-
-
SH-PTP3
-
-
-
-
SHP
-
-
-
-
SHP-1
SHP-2
SHP1
SHP2
Small tyrosine phosphatase
-
-
-
-
Small, acidic phosphotyrosine protein phosphatase
-
-
-
-
STEP
STEP33
-
STEP is processed into a 33 kDa isoform by calpain-mediated cleavage, STEP33 retains catalytic activity but is unable to bind to phosphorylated ERK
striatal-enriched PTP
String protein
-
-
-
-
Syp
-
-
-
-
T-cell protein tyrosine phosphatase
T-cell protein-tyrosine phosphatase
-
-
-
-
T-DSP11
-
-
-
-
T200
-
-
-
-
TCPTP
TcPTP1
Testis-and skeletal-muscle-specific DSP
-
-
-
-
tyrosine O-phosphate phosphatase
-
-
-
-
tyrosine phosphatase
Tyrosine phosphatase CBPTP
-
-
-
-
tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1
tyrosylprotein phosphatase
-
-
-
-
VHR
YopH
[phosphotyrosine]protein phosphatase
-
-
-
-
additional information
CD45
-
-
-
-
HEPTP
-
-
-
-
low-molecular-weight protein tyrosine phosphatase
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
-
LyP
-
-
-
-
OST-PTP
-
-
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
O14522, P10586, P17706, P18031, P18433, P23467, P23468, P23469, P23470, P23471, P26045, P28827, P29074, P29350
-
protein tyrosine phosphatase
P35236, P43378, P54829, Q05209, Q06124, Q0VAE8, Q12913, Q12923, Q13332, Q15256, Q15262, Q15678, Q16825, Q16827, Q16849, Q4JDK3, Q92729, Q92932, Q99952, Q9H3S7, Q9HD43, Q9UMZ3, Q9Y2R2
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase 1B
-
-
Protein-tyrosine phosphatase 1B
-
-
-
-
Protein-tyrosine phosphatase D1
-
-
-
-
PTP
-
-
PTP
O14522, P10586, P17706, P18031, P18433, P23467, P23468, P23469, P23470, P23471, P26045, P28827, P29074, P29350
-
PTP
P35236, P43378, P54829, Q05209, Q06124, Q0VAE8, Q12913, Q12923, Q13332, Q15256, Q15262, Q15678, Q16825, Q16827, Q16849, Q4JDK3, Q92729, Q92932, Q99952, Q9H3S7, Q9HD43, Q9UMZ3, Q9Y2R2
-
PTP-1B
-
-
-
-
PTP-BAS
-
-
-
-
PTP1B
-
-
PTPase-MEG1
-
-
-
-
PTPase-MEG2
-
-
-
-
PTPD1
-
PTPD1 is a cytosolic nonreceptor tyrosine phosphatase and a positive regulator of the Src-epidermal growth factor transduction pathway
PTPN6
-
-
-
-
PTPRO
-
a receptor-type PTP, the protein is produced from the distal promotor
RPTPalpha
-
-
-
-
Saci0545
Q4JB88
locus name, dual specific phosphatase EC 3.1.3.16/EC 3.1.3.48
Saci0545
Q4JB88
locus name, dual specific phosphatase EC 3.1.3.16/EC 3.1.3.48
-
SHP2
-
Shp2 is a nonreceptor PTP that plays a positive role in cell signaling by growth factors and cytokines and is involved in regulation of cell proliferation, differentiation, and migration
STEP
-
-
-
-
TCPTP
-
-
-
-
tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1
-
-
-
additional information
-
CRYP-2 is identical in sequence to the human glomerular epithelial protein-1
additional information
-
SHP-1 belongs to the family of non-receptor protein tyrosine phosphatases
additional information
ED-Eya2 belongs to the haloacid dehalogenase family
additional information
-
SHP-1 is a member of SH2 domain-containing PTP subfamily
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, transition state of reaction, kinetic isotope effects, overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, role of residue 182
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
thermodynamic parameters
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, kinetic isotope effects
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
comparison of kinetic properties of different transmembrane and cytosolic isozymes
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
overview on mechanism and transition state
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
overview on mechanism and transition state
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
overview on mechanism and transition state
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, features required for substrate
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
activation mechanism
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
in addition to active site, enzyme has a low-affinity noncatalytic aryl phosphate-binding site
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
H148 acts as a general acid catalyst, D115 assists the protonation of the leaving group of a substrate, and D76 and D112 are involved in binding of magnesium ions
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
conformation of active site is favorable for phosphotyrosine binding. Interaction of D115 and R13 to stabilize the conformation of the active cavity. A41 and G45 form a noncharged surface around the active cavity, which is surrounded by a flexible wall made of the loop region from F40 to T48
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
arrangement of two metal ions, a phosphate ion, and amino acid residues in the catalytic site is identical to that of PS/Tpases
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
motif H74C(X)5R81 is involved in catalysis
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
ping-pong mechanism, catalysis proceeds through a two-step mechanism involving a phosphocysteine intermediate. In the first step, a nucleophilic cysteine thiolate attacks the phosphate ester moiety of the substrate, resulting in formation of a phosphoenzyme intermediate with release of the peptidyl tyrosine. The second step occurs via attack of water on the phosphoenzyme intermediate, and yields the final products inorganic phosphate and the regenerated enzyme. The central binding site for the substrate is the P-loop, a region at the bottom of a pocket that includes the nucleophilic cysteine and backbone amide groups oriented in a horseshoe fashion, catalytic cycle, detailed overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism of the dephosphorylation catalysed by MptpA
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
protein-tyrosine-phosphate phosphohydrolase
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
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CAS REGISTRY NUMBER
COMMENTARY
79747-53-8
-
97162-86-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-O-methylfluorescein phosphate + H2O
3-O-methylfluorescein + phosphate
-
-
-
-
?
4-methylumbelliferyl phosphate + H2O
4-methylumbelliferone + phosphate
-
-
-
-
?
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferol + phosphate
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferone + phosphate
Ac-DGEEpYDDPF-NH2 + H2O
Ac-DGEEYDDPF-NH2 + phosphate
-
SKAP-HOM Tyr75 peptide
-
-
?
Ac-YGEEpYDDLY-NH2 + H2O
Ac-YGEEYDDLY-NH2 + phosphate
-
consensus peptide 1
-
-
?
Ac-YGYEpYDDEY-NH2 + H2O
Ac-YGYEYDDEY-NH2 + phosphate
-
consensus peptide 2
-
-
?
bis-(p-phosphophenyl) methane + H2O
?
synthetic high-affinity low-molecular weight nonpeptide substrate
-
-
?
carrier protein-Cdc2-phosphotyrosine + H2O
carrier protein-Cdc2-tyrosine + phosphate
-
-
-
-
?
carrier protein-Y3-phosphotyrosine + H2O
carrier protein-Y3-tyrosine + phosphate
-
-
-
-
?
carrier protein-Y5-phosphotyrosine + H2O
carrier protein-Y5-tyrosine + phosphate
-
-
-
-
?
Cdk2-pTpY + H2O
Cdk2-TpY + phosphate
-
dephosphorylates Cdk/cyclins on pThr14 and/or pTyr15 residues
-
-
?
difluoromethylumbelliferyl phosphate + H2O
difluoromethylumbelliferone + phosphate
-
-
-
?
epidermal growth factor receptor + H2O
? + phosphate
-
with phosphotyrosine Tyr992
-
-
?
FMN + H2O
? + phosphate
-
71.8% of the activity with 4-nitrophenyl phosphate, lung enzyme
-
-
?
GESDGGpYMDMSKD + H2O
GESDGGYMDMSKD + phosphate
-
this peptide corresponds to the sequence containing Tyr740 of the human platelet-derived growth factor receptor
-
-
?
hirudin + H2O
? + phosphate
-
hirudin from leech, phosporylated on tyrosine
-
-
?
KRLIEDNE(pY)TARGQ + H2O
KRLIEDNEYTARGQ + phosphate
-
phosphopeptide derived from autophosphorylation of mammalian tyrosine kinase Lck
-
-
?
lysozyme + H2O
? + phosphate
-
reduced, carboxymethylated and maleylated
-
-
?
nicotinic acetylcholine receptor + H2O
? + phosphate
-
i.e. nAChR
-
-
?
phosphorylated Abelson interacting protein + H2O
Abelson interacting protein + phosphate
-
-
-
-
?
phosphorylated Abl tyrosine kinase + H2O
Abl tyrosine kinase + phosphate
-
-
-
-
?
phosphorylated adenomatous Polyposis coli-protein + H2O
adenomatous Polyposis coli-protein + phosphate
-
-
-
-
?
phosphorylated AMP-activated protein kinase + H2O
AMP-activated protein kinase + phosphate
phosphorylated c-Kit + H2O
c-Kit + phosphate
-
dephosphorylation occurs at tyrosines 567/569 and 719
-
-
?
phosphorylated Cdk2-pTpY/CycA protein + H2O
Cdk2-pTpY/CycA protein + phosphate
-
-
-
?
phosphorylated colony-stimulating factor 1 receptor + H2O
colony-stimulating factor 1 + phosphate
-
-
-
-
?
phosphorylated Down syndrome cell adhesion molecule + H2O
Down syndrome cell adhesion molecule + phosphate
-
-
-
-
?
phosphorylated epidermal growth factor receptor + H2O
epidermal growth factor receptor + phosphate
phosphorylated ERK2 + H2O
ERK2 + phosphate
HePTP binds the phosphorylated tyrosine of the Erk2 peptide (pY185), Erk2 residue T183, which is phosphorylated in maximally activated Erk2, is not essential for substrate recognition and binding by HePTP
-
-
?
phosphorylated eukaryotic-initiation-factor-4G + H2O
eukaryotic-initiation-factor-4G + phosphate
-
-
-
-
?
phosphorylated extracellular signal regulated kinase + H2O
extracellular signal regulated kinase + phosphate
-
-
-
-
?
phosphorylated extracellular signal-regulated kinase 1 + H2O
extracellular signal-regulated kinase 1 + phosphate
phosphorylated extracellular signal-regulated kinase 2 + H2O
extracellular signal-regulated kinase 2 + phosphate
phosphorylated focal adhesion kinase + H2O
focal adhesion kinase + phosphate
-
dephosphorylation occurs at Tyr-397, PTPD1 activity is required for focal adhesion kinase autophosphorylation and adhesion plaque stability
-
-
?
phosphorylated fragile X related + H2O
fragile X related + phosphate
-
-
-
-
?
phosphorylated Gln3 + H2O
Gln3 + phosphate
-
Siw14, in combination with the protein kinase Npr1, regulates the intracellular localization of Gln3
-
-
?
phosphorylated hepatocyte growth factor regulated tyrosine kinase substrate + H2O
hepatocyte growth factor regulated tyrosine kinase substrate + phosphate
-
-
-
-
?
phosphorylated IGF-I receptor + H2O
IGF-I receptor + phosphate
-
isozyme p52shc
-
-
?
phosphorylated IGF-II mRNA-binding protein + H2O
IGF-II mRNA-binding protein + phosphate
-
-
-
-
?
phosphorylated insulin receptor substrate-1 + H2O
insulin receptor substrate-1 + phosphate
-
-
-
-
?
phosphorylated insulin receptor substrate-2 + H2O
insulin receptor substrate-2 + phosphate
-
-
-
-
?
phosphorylated JAK2 + H2O
JAK2 + phosphate
-
SHP2 dephosphorylates the Tyr1007 site, preventing the formation of the JAK2-Socs1 complex
-
-
?
phosphorylated Jun amino-terminal kinase + H2O
Jun amino-terminal kinase + phosphate
-
-
-
-
?
phosphorylated Lck + H2O
Lck + phosphate
-
component of the T cell receptor signaling pathway
-
-
?
phosphorylated mitogen-activated protein kinase + H2O
mitogen-activated protein kinase + phosphate
-
-
-
-
?
phosphorylated mitogen-activated protein kinase Pmk1p + H2O
mitogen-activated protein kinase Pmk1p + phosphate
phosphorylated Munc18c + H2O
Munc18c + phosphate
-
dephosporylation at Tyr218/219 and Tyr521
-
-
?
phosphorylated p130 Crk-associated substrate + H2O
p130 Crk-associated substrate + phosphate
-
-
-
-
?
phosphorylated p190B Rho-GTPase-activating protein + H2O
p190B Rho-GTPase-activating protein + phosphate
-
-
-
-
?
phosphorylated p38 mitogen-activated protein kinase + H2O
p38 mitogen-activated protein kinase + phosphate
phosphorylated PDGF- and VEGF-receptor related + H2O
PDGF- and VEGF-receptor related + phosphate
-
-
-
-
?
phosphorylated platelet-derived growth factor receptor + H2O
platelet-derived growth factor receptor + phosphate
-
-
-
-
?
phosphorylated poly(A)-binding protein + H2O
poly(A)-binding protein + phosphate
-
-
-
-
?
phosphorylated proline serine threonine-rich phosphatase interacting protein + H2O
proline serine threonine-rich phosphatase interacting protein + phosphate
-
-
-
-
?
phosphorylated proline-rich tyrosine kinase 2 + H2O
proline-rich tyrosine kinase 2 + phosphate
-
the enzyme directly binds to and dephosphorylates proline-rich tyrosine kinase 2 at Tyr402
-
-
?
phosphorylated protein kinase-like endoplasmic reticulum kinase + H2O
protein kinase-like endoplasmic reticulum kinase + phosphate
-
dephosphorylation at Tyr615
-
-
?
phosphorylated pyruvate kinase M2 + H2O
pyruvate kinase M2 + phosphate
-
-
-
-
?
phosphorylated RET(C634R) oncoprotein + H2O
RET(C634R) oncoprotein + phosphate
-
dephosphorylation at Tyr905 and Tyr1062
-
-
?
phosphorylated RET-MEN2A oncoprotein + H2O
RET-MEN2A oncoprotein + phosphate
-
dephosphorylation at Tyr905 and Tyr1062
-
-
?
phosphorylated RET/PTC1 oncoprotein + H2O
RET/PTC1 oncoprotein + phosphate
-
dephosphorylation at Tyr905 and Tyr1062
-
-
?
phosphorylated signal transducer and activator of transcription 3 + H2O
signal transducer and activator of transcription 3 + phosphate
-
-
-
-
?
phosphorylated specifically Rac1-associated protein 1 + H2O
specifically Rac1-associated protein 1 + phosphate
-
-
-
-
?
phosphorylated Src tyrosine kinase + H2O
Src tyrosine kinase + phosphate
-
PTPD1 associates with and activates Src tyrosine kinase
-
-
?
phosphorylated STAT5 + H2O
STAT5 + phosphate
-
purified SHP2 protein directly dephosphorylates STAT5 or tyrosine-phosphorylated peptides derived from STAT5
-
-
?
phosphorylated T cell antigen receptor chain zeta + H2O
T cell antigen receptor chain zeta + phosphate
-
-
-
-
?
phosphorylated T cell antigen receptor zeta + H2O
T cell antigen receptor zeta + phosphate
-
-
-
-
?
phosphorylated T-cell receptor-zeta subunit + H2O
T-cell receptor-zeta subunit + phosphate
-
dephosphorylates ITAMs of the T-cell receptor-zeta subunit
-
-
?
phosphorylated TCRzeta + H2O
TCRzeta + phosphate
-
PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway
-
-
?
phosphorylated valosin containing protein + H2O
valosin containing protein + phosphate
-
-
-
-
?
phosphorylated vascular endothelial growth factor receptor 2 + H2O
vascular endothelial growth factor receptor 2 + phosphate
phosphorylated Vav + H2O
Vav + phosphate
-
component of the T cell receptor signaling pathway
-
-
?
phosphorylated voltage-gated potassium channel subunit Kv2.1 + H2O
voltage-gated potassium channel subunit Kv2.1 + phosphate
-
-
-
-
?
phosphorylated YwqD
YwqD + phosphate
-
protein implicated in UDP-glucuronate synthesis
-
-
?
phosphorylated YwqF
YwqF + phosphate
-
protein implicated in UDP-glucuronate synthesis
-
-
?
phosphotyrosyl myelin basic protein + H2O
tyrosyl-myelin basic protein + phosphate
-
-
-
-
?
phosphotyrosyl reduced carboxyamidomethylated and maleylated lysozyme + H2O
tyrosyl-reduced carboxyamidomethylated and maleylated lysozyme + phosphate
-
-
-
-
?
SKAP-HOM + H2O
?
-
a cytosolic adaptor protein required for proper activation of the immune system, a bona fide Lyp substrate
-
-
?
soluble N-ethylmaleimide-sensitive factor attachment protein receptor + H2O
soluble N-ethylmaleimide-sensitive factor attachment protein receptor + phosphate
-
-
-
-
?
TGFLTELpYVATRWY + H2O
TGFLTELYVATRWY + phosphate
-
this peptide corresponds to the sequence containing Tyr204 of the human extracellular signal-regulated kinase
-
-
?
tyrosine-phosphorylated myelin basic protein + H2O
myelin basic protein + phosphate
-
-
-
?
YCRPESQEHPEADPGAAPpYLK + H2O
YCRPESQEHPEADPGAAYLK + phosphate
-
YCRPESQEHPEADPGAApYLK is signal transducer and activator of transcription 3, is dephosphorylated at Y705
-
-
?
[EGF receptor]-tyrosine1018 phosphate + H2O
[EGF receptor]-tyrosine1018 + phosphate
B4FJN0
highest activity
-
-
?
[insulin receptor kinase]-tyrosine phosphate + H2O
[insulin receptor kinase]-tyrosine + phosphate
-
-
-
-
?
1-naphthyl phosphate + H2O
1-naphthol + phosphate
-
89.3% of the activity with 4-nitrophenyl phosphate, lung enzyme
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
nitrophenol + phosphate
Q4JB88
-
-
-
?
4-nitrophenyl phosphate + H2O
nitrophenol + phosphate
Q4JB88
-
-
-
?
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferol + phosphate
-
-
-
-
?
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferol + phosphate
-
-
-
-
?
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferone + phosphate
-
-
-
-
?
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferone + phosphate
-
-
-
-
?
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferone + phosphate
-
-
-
?
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferone + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
9.5% activity compared to TRDIpYETDYYRK
-
-
?
ATP + H2O
ADP + phosphate
-
9.5% activity compared to TRDIpYETDYYRK
-
-
?
bovine serum albumin + H2O
? + phosphate
-
reduced, carboxamide methylated and succinylated
-
-
?
DADEpYIPQQG + H2O
DADEYIPQQG + phosphate
-
specific substrate for PTP1B
-
-
?
insulin receptor phosphopeptide + H2O
insulin receptor peptide + phosphate
-
-
-
-
?
insulin receptor phosphopeptide + H2O
insulin receptor peptide + phosphate
-
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
60.3% activity compared to TRDIpYETDYYRK
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
60.3% activity compared to TRDIpYETDYYRK
-
-
?
paxilin tyrosine phosphate + H2O
paxilin tyrosine + phosphate
-
PTPRT specifically regulates paxillin phosphorylation at Tyr88 in colorectal cancer cells
-
-
?
paxilin tyrosine phosphate + H2O
paxilin tyrosine + phosphate
-
substrate of PTPRT, inactive with paxilin mutant Y88F
-
-
?
phosphorylated AMP-activated protein kinase + H2O
AMP-activated protein kinase + phosphate
-
PTPB1 is involved in AMPK regulation through its phosphorylation in a tissue-specific manner, overview
-
-
?
phosphorylated AMP-activated protein kinase + H2O
AMP-activated protein kinase + phosphate
-
phosphorylation of the AMPK alpha subunit at Thr172
-
-
?
phosphorylated c-MET + H2O
c-MET + phosphate
-
PTP1B and SHP-2 are bound to the c-Met receptor to control its activity, PTP1B acts as a negative regulator, increased binding and phosphorylation of SHP-2 coincide with maximal stimulation of c-Met, therefore acting as a positive regulator
-
-
?
phosphorylated c-MET + H2O
c-MET + phosphate
-
PTP1B and SHP-2 are bound to the c-Met receptor to control its activity, PTP1B acts as a negative regulator, increased binding and phosphorylation of SHP-2 coincide with maximal stimulation of c-Met, therefore acting as a positive regulator
-
-
?
phosphorylated c-Src + H2O
c-Src + phosphate
-
dephosphorylation activates c-Src
-
-
?
phosphorylated c-Src + H2O
c-Src + phosphate
-
dephosphorylation occurs at Tyr-527
-
-
?
phosphorylated epidermal growth factor receptor + H2O
epidermal growth factor receptor + phosphate
-
-
-
-
?
phosphorylated epidermal growth factor receptor + H2O
epidermal growth factor receptor + phosphate
-
-
preferential dephosphorylation at Y1068 and Y1173
-
?
phosphorylated epidermal growth factor receptor + H2O
epidermal growth factor receptor + phosphate
-
PTP1B negatively regulates EGF-induced signaling in HCEC cells by dephosphorylating the epidermal growth factor receptor
-
-
?
phosphorylated epidermal growth factor receptor + H2O
epidermal growth factor receptor + phosphate
-
inactivation of EGFR
-
-
?
phosphorylated epidermal growth factor receptor + H2O
epidermal growth factor receptor + phosphate
-
-
-
-
?
phosphorylated ERK + H2O
ERK + phosphate
-
the cleavage of STEP leads to a catalytically active form, but this cleaved form no longer binds to and dephosphorylates its substrate phosphorylated ERK
-
-
?
phosphorylated extracellular signal-regulated kinase 1 + H2O
extracellular signal-regulated kinase 1 + phosphate
-
-
-
-
?
phosphorylated extracellular signal-regulated kinase 1 + H2O
extracellular signal-regulated kinase 1 + phosphate
-
-
-
-
?
phosphorylated extracellular signal-regulated kinase 2 + H2O
extracellular signal-regulated kinase 2 + phosphate
-
-
-
-
?
phosphorylated extracellular signal-regulated kinase 2 + H2O
extracellular signal-regulated kinase 2 + phosphate
-
-
-
-
?
phosphorylated insulin receptor + H2O
insulin receptor + phosphate
-
-
-
?
phosphorylated insulin receptor + H2O
insulin receptor + phosphate
-
-
preferential dephosphorylation of Y1162/1163 of insulin receptor
-
?
phosphorylated mitogen-activated protein kinase Pmk1p + H2O
mitogen-activated protein kinase Pmk1p + phosphate
-
-
-
-
?
phosphorylated mitogen-activated protein kinase Pmk1p + H2O
mitogen-activated protein kinase Pmk1p + phosphate
-
-
-
-
?
phosphorylated p38 mitogen-activated protein kinase + H2O
p38 mitogen-activated protein kinase + phosphate
-
-
-
-
?
phosphorylated p38 mitogen-activated protein kinase + H2O
p38 mitogen-activated protein kinase + phosphate
-
-
-
?
phosphorylated phospholipase Cgamma + H2O
phospholipase Cgamma + phosphate
-
dephosphorylation occurs at Tyr-783
-
-
?
phosphorylated phospholipase Cgamma + H2O
phospholipase Cgamma + phosphate
-
dephosphorylation occurs at Tyr-783
-
-
?
phosphorylated Src + H2O
Src + phosphate
-
DEP-1 is able to dephosphorylate the inhibitory Y529 and activate Src
-
-
?
phosphorylated STAT1 + H2O
STAT1 + phosphate
-
purified GST-SHP2 dephosphorylates STAT1 at both tyrosine and serine residues when immunoprecipitated phosphorylated STAT1 or phosphor-peptides corresponding to the sequence surrounding Tyr701 or Ser727 of STAT1 are used as the substrates, SHP2 negatively regulates the interferon-induced JAK/STAT pathway by dephosphorylating STAT1
-
-
?
phosphorylated STAT1c + H2O
STAT1c + phosphate
-
mode of STAT activation, whereby serine-threonine phosphorylation of the cognate protein tyrosine phosphatase PTP3 results in the inhibition of its activity, shifting the phosphorylation-dephosphorylation equilibrium in favour of phosphorylation, overview
-
-
?
phosphorylated STAT3 + H2O
STAT3 + phosphate
-
SHP2 negatively regulates the activity of STAT3
-
-
?
phosphorylated vascular endothelial growth factor receptor 2 + H2O
vascular endothelial growth factor receptor 2 + phosphate
-
-
-
-
?
phosphorylated vascular endothelial growth factor receptor 2 + H2O
vascular endothelial growth factor receptor 2 + phosphate
-
dephosphorylation occurs at Tyr-1175, PTP1B binds to vascular endothelial growth factor receptor 2 cytoplasmic domain and directly dephosphorylates activated vascular endothelial growth factor receptor 2 immunoprecipitates
-
-
?
phosphotyrosine + H2O
tyrosine + phosphate
-
45.2% of the activity with 4-nitrophenyl phosphate, lung enzyme
-
-
?
phosphotyrosine + H2O
tyrosine + phosphate
O14522, P10586, P17706, P18433, P23468, P23469, P23470, P23471, P26045, P28827, P29074, P43378, P54829, Q05209, Q06124, Q0VAE8, Q12913, Q12923, Q13332, Q15256, Q15262, Q15678, Q16825, Q16827, Q16849, Q4JDK3, Q92729, Q92932, Q99952, Q9H3S7, Q9HD43, Q9UMZ3, Q9Y2R2
-
-
-
?
phosphotyrosyl-STAT3 + H2O
STAT3 + phosphate
-
signal transducers and activator of transcription 3, STAT3, is a transcription factor that is associated with survival, proliferation, chemoresistance, and angiogenesis of tumor cells
-
-
?
platelet-derived growth factor receptor + H2O
? + phosphate
-
with phosphotyrosine Tyr1021 or Tyr1009
-
-
?
TEVGKRI(pY)RLVGDKN + H2O
TEVGKRIYRLVGDKN + phosphate
Q4JB88
-
-
-
?
TEVGKRI(pY)RLVGDKN + H2O
TEVGKRIYRLVGDKN + phosphate
Q4JB88
-
-
-
?
TRDIpYETDYYRK + H2O
TRDIYETDYYRK + phosphate
-
100% activity
-
-
?
TSTEPQpYQPGENL + H2O
TSTEPQYQPGENL + phosphate
-
this sequence contains the C-terminal phosphorylation site of c-src with phosphorylated Tyr527
-
-
?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
-
-
-
-
?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
-
-
-
-
?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
-
-
-
-
?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
-
-
-
-
?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
-
-
-
-
?
[protein]-L-tyrosine phosphate + H2O
[protein]-L-tyrosine + phosphate
Q4JB88
-
-
-
?
[protein]-L-tyrosine phosphate + H2O
[protein]-L-tyrosine + phosphate
Q4JB88
-
-
-
?
additional information
?
-
-
PTP is an element of the abscisic acid signaling pathway that leads to stomatal closure
-
-
-
additional information
?
-
-
no substrate: phosphoeptides RRA(pS)VA, KR(pT)IRR
-
-
-
additional information
?
-
-
the enzyme does not display catalytic activity against some common protein tyrosine phosphatase substrates (O-nitrophenyl beta-D-galactopyranoside, O-phospho-L-threonine, D-fructose 6-phosphate, D-ribose 5-phosphate, D-glucose 6-phosphate, D-glucose 1-phosphate) but is highly specific for hydrolysis of phosphomonoester bonds of inositol hexakisphosphate
-
-
-
additional information
?
-
the enzyme does not display catalytic activity against some common protein tyrosine phosphatase substrates (O-nitrophenyl beta-D-galactopyranoside, O-phospho-L-threonine, D-fructose 6-phosphate, D-ribose 5-phosphate, D-glucose 6-phosphate, D-glucose 1-phosphate) but is highly specific for hydrolysis of phosphomonoester bonds of inositol hexakisphosphate
-
-
-
additional information
?
-
the enzyme does not display catalytic activity against some common protein tyrosine phosphatase substrates (O-nitrophenyl beta-D-galactopyranoside, O-phospho-L-threonine, D-fructose 6-phosphate, D-ribose 5-phosphate, D-glucose 6-phosphate, D-glucose 1-phosphate) but is highly specific for hydrolysis of phosphomonoester bonds of inositol hexakisphosphate
-
-
-
additional information
?
-
-
STATc becomes tyrosine phosphorylated and accumulates in the nucleus when Dictyostelium cells are exposed to the prestalk cell inducer Differentiation inducing factor 1, DIF-1, or are subjected to hyperosmotic stress
-
-
-
additional information
?
-
-
no hydrolysis of serine phosphate, threonine phosphate, nicotinamide adenine dinucleotide phosphate
-
-
-
additional information
?
-
-
kinetic constants for several peptide substrates
-
?
additional information
?
-
-
study on substrate specificity, screen of peptide substrate library
-
?
additional information
?
-
-
PTPases regulate the ligand-induced autophosphorylation of PTK growth factor receptors, the phosphotyrosine-mediated binding s of src homology 2 (SH2)-domain-containing proteins to autophosphorylated PTK growth factor receptors and the activation state of the src family pf PTK
-
-
-
additional information
?
-
-
LMW-PTP is involved in the negative regulation of the mitogenic stimulus starting from the activated PDGF receptor. The interaction between LMW-PTP results in the dephosphorylation of the PDGF-R phosphortyrosine and a negative regulation of the mitogenic signal
-
-
-
additional information
?
-
-
regulation of the function of epidermal growth factor receptor in keratinocytes by its dephosphorylation
-
-
-
additional information
?
-
-
SHP-1 may regulate the tethering of receptors to the cytoskeleton and/or the extent of cross-linking of actin filaments in platelets
-
-
-
additional information
?
-
-
Cdc25 phosphatases prefer a bisanionic over a monoanionic substrate
-
-
-
additional information
?
-
-
activation of SPH-1 and SPH-2 is accompanied by reduced responsiveness to aggregating agents, phosphorylation of SPH-1 and SPH-2 introduces docking sites for adaptor molecules like growth factor receptor-bound protein 2 regulating further signaling to integrin alphaIIbbeta3
-
-
-
additional information
?
-
-
by modulating Src-focal adhesion kinase signaling at adhesion sites, PTPD1 promotes the cytoskeleton events that induce cell adhesion and migration
-
-
-
additional information
?
-
-
functional inactivation of the protein tyrosine phosphatase DEP-1 leads to increased endothelial cell proliferation and failure of vessels to remodel and branch
-
-
-
additional information
?
-
-
human LMW-PTP is critical in the regulation of mitogenic signalling and Rho-mediated cytoskeletal rearrangements after platelet derived growth factor stimulation
-
-
-
additional information
?
-
-
SHP-2, MKP-1, LAR, and PTEN are targets of platelet-derived growth factor-induced reversible oxidation
-
-
-
additional information
?
-
-
DEP-1 is a positive regulator of VEGF-mediated Src and Akt activation and endothelial cell survival
-
-
-
additional information
?
-
ED-Eya2 is bifunctional acting as protein tyrosine phosphatase and as transcription factor. The transcriptional activity of Eya proteins is regulated by a dephosphorylating activity within its Eya domain, structure-function analysis, overview
-
-
-
additional information
?
-
-
isozyme p52shc associates with the growth factor receptor-bound protein-2, Grb2. Overexpression of isozyme p66shc impaires IGF-I-stimulated p52shc tyrosine phosphorylation and p52shc-Grb2 association. Isozyme p66shc inhibits IGF-I signal transduction via competitively inhibiting the binding of Src homology 2 domain-containing SHP-2 to SHP substrate-1, leading to the disruption of SHPS-1/SHP-2/Src/p52shc complex formation, an event that is essential for p52shc phosphorylation and Grb2 recruitment, overview. p66shc inhibits IGF-I signal transduction via impairing membrane recruitment of Grb2
-
-
-
additional information
?
-
-
protein tyrosine phosphatase 1B, PTP1B, is an intracellular non-receptor type PTP
-
-
-
additional information
?
-
-
formation and structure of a transition state analogue for the first catalytic step comprising a ternary complex between the catalytic cysteine of PTP1B, vanadate, and the peptide DADEYL, a fragment of a physiological substrate, overview. The equatorial vanadate oxygen atoms bind to the P-loop, and the apical positions are occupied by the peptide tyrosine oxygen and by the PTP1B cysteine sulfur atom. The vanadate assumes a trigonal bipyramidal geometry in both transition state analogue structures, with very similar apical O-O distances, denoting similar transition states for both phosphoryl transfer steps
-
-
-
additional information
?
-
-
PTEN phosphoprotein phosphatase catalysis of phosphoprotein dephosphorylation follows a two-step mechanism with Cys124 transiently phosphorylated to form the phosphoenzyme intermediate
-
-
-
additional information
?
-
-
Ser380, Thr382 and Thr383 C-terminal tail residues do not affect the recruitment of the WPD-loop into the active site to participate in the phosphoprotein dephosphorylation reaction, catalytic mechanism of PTEN phosphoprotein phosphatase activity, overview. The phosphoPTEN protein is not the cysteinyl phosphoenzyme intermediate formed by transient phosphorylation of Cys124 in the course of phosphopeptide dephosphorylation reaction. PTEN can adopt the closed conformation to allow Asp92 to participate in catalysis when it dephosphorylates the physiological protein substrates such as FAK and Shc in cells
-
-
-
additional information
?
-
-
substrate specificity analysis using a trapping mutant of the phosphatase, which is a point mutation that maintains specificity but does not allow detachment of the phosphate, overview. The enzyme is also active on 4-nitrophenyl phosphate, but is not active on GRB2
-
-
-
additional information
?
-
-
substrate specificity of lymphoid-specific tyrosine phosphatase, identification of consensus sequence motifs for Lyp substrate recognition using an inverse alanine scanning combinatorial library approach, molecular determinants and molecular basis for Lyp substrate recognition, crystal structure analysis, overview
-