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acid phosphatase activity
-
-
acid phosphatase ortholog
-
the enzyme share the conserved RHGXRXP motif characteristic of the histidine acid phosphatase family
acid tyrosine phosphatase
-
-
Brain-derived phosphatase
-
-
-
CD45 protein tyrosine phosphatase
CDK2-associated dual specificity phosphatase
-
-
-
chick retinal tyrosine phosphatase-2
-
-
cold-active protein tyrosine phosphatase
-
CRYP-2/receptor-type tyrosine-protein phosphatase O
-
-
cysteine-dependent protein tyrosine phosphatase
cyt-PTPepsilon
-
non-receptor-type isoform of PTPepsilon
density-enhanced phosphatase-1
-
dPTP61F
-
dPTP61F plays a central role in counteracting PTK-mediated signaling pathways as well as in regulating actin reorganization and remodeling through tyrosine dephosphorylation of critical substrates in Drosophila
dual specificity phosphatase
Dual specificity phosphatase Cdc25A
-
-
-
Dual specificity phosphatase Cdc25B
-
-
-
Dual specificity phosphatase Cdc25C
-
-
-
dual specificity protein phosphatase 23
UniProt
dual specificity protein phosphatase 3
UniProt
Dual specificity protein phosphatase hVH1
-
-
-
Dual specificity protein phosphatase hVH2
-
-
-
Dual specificity protein phosphatase hVH3
-
-
-
Dual specificity protein phosphatase PYST1
-
-
-
Dual specificity protein phosphatase PYST2
-
-
-
Dual specificity protein phosphatase VHR
-
-
-
dual specifity protein phosphatase
-
dual-specificity (Thr/Tyr) MAPK protein phosphatase
-
-
dual-specificity phosphatase
dual-specificity protein phosphatase
-
-
dual-specificity protein tyrosine phosphatase 18
-
-
Dual-specificity tyrosine phosphatase TS-DSP6
-
-
-
Dual-specificity tyrosine phosphatase YVH1
-
-
-
ES cell phosphatase
-
-
-
Hematopoietic cell protein-tyrosine phosphatase
-
-
-
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
-
-
-
hematopoietic protein tyrosine phosphatase
-
-
Hematopoietic protein-tyrosine phosphatase
-
-
-
hematopoietic tyrosine phosphatase
-
His domain protein tyrosine phosphatase
histidine acid phosphatase
-
-
histidine domain-protein tyrosine phosphatase
-
-
HPTP beta-like tyrosine phosphatase
-
-
-
insulinoma associated protein tyrosine phosphatase 2
-
islet cell antigen-related PTP
-
-
Islet cell autoantigen related protein
-
-
-
kinase associated phosphatase
-
-
-
kinase interaction motif phosphatase
-
kinase interaction motif-containing protein tyrosine phosphatases
-
-
LCA-related phosphatase
-
-
-
leucocyte common antigen-related protein tyrosine phosphatase
Leukocyte antigen related
-
-
-
leukocyte common antigen-related
-
-
low molecular mass dual specificity phosphatase 3
UniProt
Low molecular weight cytosolic acid phosphatase
-
-
-
Low molecular weight phosphotyrosine protein phosphatase
low molecular weight protein tyrosine phosphatase
low molecular weight protein-tyrosine phosphatase A
-
low molecular weight-PTP
-
-
low-molecular weight PTPase
low-molecular-weight protein tyrosine phosphatase
Lymphoid phosphatase
-
-
-
lymphoid-specific tyrosine phosphatase
-
-
MAP-kinase phosphatase CPG21
-
-
-
MAPK-specific tyrosine phosphatase
-
mitogen-activated protein kinase phosphatase
-
mitogen-activated protein kinase phosphatase-1
-
-
mitogen-activated protein kinase-specific tyrosine phosphatase
-
Mitosis initiation protein
-
-
-
Mitosis initiation protein MIH1
-
-
-
Mitotic inducer homolog
-
-
-
MKP-1
-
trivial names CL100, erp, 3CH134, hVH1
MKP-1 like protein tyrosine phosphatase
-
-
-
MKP-2
-
trivial names Typ1, Sty8, hVH2
MKP-X
-
trivial names Pyst2, B59
MKP1
-
a dual-specificity phosphatase
MKP5-C
catalytic domain of MKP5
Neural-specific protein-tyrosine phosphatase
-
-
-
non-receptor protein tyrosine phosphatase
orphan protein tyrosine phosphatase
osteoclastic protein-tyrosine phosphatase
-
phosphatase of regenerating liver-3
-
-
phosphatase, phosphoprotein (phosphotyrosine)
-
-
-
phosphatase, phosphotyrosine
-
-
-
phosphoprotein phosphatase (phosphotyrosine)
-
-
-
phosphotyrosine histone phosphatase
-
-
-
phosphotyrosine phosphatase
-
-
-
Phosphotyrosine phosphatase 13
-
-
-
phosphotyrosine phosphatase 1B
-
-
phosphotyrosine protein phosphatase
-
-
-
phosphotyrosine-specific PP
-
-
phosphotyrosylprotein phosphatase
-
-
-
PPM
-
the recombinant protein exhibits protein-tyrosine phosphatase in addition to its predicted protein-serine/threonine phosphatase activity
PRL-related protein tyrosine phosphatase
-
-
probable low molecular weight protein-tyrosine-phosphatase
protein of regenerating liver-related protein tyrosine phosphatase
-
-
protein phosphatase 2A
-
-
protein phosphotyrosine phosphatase
-
-
-
protein Tyr phosphatase
-
-
protein tyrosine phosphatase
protein tyrosine phosphatase 1B
protein tyrosine phosphatase A
-
-
protein tyrosine phosphatase alpha
-
-
protein tyrosine phosphatase B
-
-
protein tyrosine phosphatase beta
-
protein tyrosine phosphatase epsilon
protein tyrosine phosphatase eta
-
-
protein tyrosine phosphatase H1
-
-
protein tyrosine phosphatase N12
-
protein tyrosine phosphatase N3
-
protein tyrosine phosphatase ny
-
-
Protein tyrosine phosphatase receptor-type T
-
-
protein tyrosine phosphatase SHP-1
-
-
protein tyrosine phosphatase sigma
-
-
protein tyrosine phosphatase xi
-
-
protein tyrosine phosphatase, non-receptor type 1
-
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
-
-
protein tyrosine phosphatase-1B
protein tyrosine phosphatase-2
-
-
protein tyrosine phosphatase-BL
-
-
protein tyrosine phosphatase-H2
-
-
Protein tyrosine phosphatase-NP
-
-
-
protein tyrosine phosphatase-PEST
-
-
Protein-protein-tyrosine phosphatase HA2
-
-
-
protein-tyrosine phosphatase
Protein-tyrosine phosphatase 1B
Protein-tyrosine phosphatase 1C
-
-
-
Protein-tyrosine phosphatase 1E
-
-
-
Protein-tyrosine phosphatase 2C
-
-
-
Protein-tyrosine phosphatase 2E
-
-
-
Protein-tyrosine phosphatase 3CH134
-
-
-
protein-tyrosine phosphatase alpha
-
-
Protein-tyrosine phosphatase CL100
-
-
-
Protein-tyrosine phosphatase D1
Protein-tyrosine phosphatase ERP
-
-
-
Protein-tyrosine phosphatase G1
-
-
-
Protein-tyrosine phosphatase H1
-
-
-
Protein-tyrosine phosphatase LC-PTP
-
-
-
Protein-tyrosine phosphatase MEG1
-
-
-
Protein-tyrosine phosphatase MEG2
-
-
-
Protein-tyrosine phosphatase P19
-
-
-
Protein-tyrosine phosphatase PCPTP1
-
-
-
Protein-tyrosine phosphatase pez
-
-
-
Protein-tyrosine phosphatase PTP-RL10
-
-
-
Protein-tyrosine phosphatase PTP36
-
-
-
Protein-tyrosine phosphatase PTPL1
-
-
-
Protein-tyrosine phosphatase striatum-enriched
-
-
-
Protein-tyrosine phosphatase SYP
-
-
-
Protein-tyrosine-phosphatase SL
-
-
-
Protein-tyrosine-phosphate phosphohydrolase
-
-
-
PTEN phosphoprotein phosphatase
-
-
PTP-SL
-
receptor-type isoform
PTPepsilonC
-
non-receptor-type isoform of PTPepsilon
PTPepsilonM
-
receptor-type isoform of PTPepsilon
PTPetaCD
-
catalytic domain of protein tyrosine phosphatase eta
PTPN4/PTP-MEG1
-
a PTPH1-family member
PTPPBSgamma
-
cytosolic isoform
PTPPBSgamma-37
-
cytosolic isoform
PTPPBSgamma-42
-
cytosolic isoform
PTPRO, truncated
-
the protein is produced from the proximal promotor
PTPROt
-
the protein is produced from the proximal promotor
PY protein phosphatase
-
-
-
receptor protein tyrosine phosphatase
-
-
receptor protein tyrosine phosphatase isoform delta
-
receptor protein tyrosine phosphatase isoform omega
-
receptor protein tyrosine phosphatase rho
receptor protein tyrosine phosphatase T
-
-
receptor protein tyrosine phosphatase {kappa}
-
-
Receptor-linked protein-tyrosine phosphatase 10D
-
-
-
Receptor-linked protein-tyrosine phosphatase 99A
-
-
-
receptor-type protein tyrosine phosphatase J
-
-
Receptor-type protein-tyrosine phosphatase-kappa
-
-
receptor-type tyrosine-protein phosphatase R
UniProt
reductant-inhibited PTPase1
-
RNA/RNP complex-intereracting phosphatase
-
-
-
Scr homology 2-containing tyrosine phosphatase
-
-
selective striatal enriched protein phosphatase
-
SH2 domain-containing tyrosine phosphatase-1
-
-
SH2 domain-containing tyrosine phosphatase-2
-
-
Small tyrosine phosphatase
-
-
-
Small, acidic phosphotyrosine protein phosphatase
-
-
-
specific protein-tyrosine phosphatase
-
Src homology 2 domain-containing phosphatase-1
-
-
Src homology region 2 domain-containing phosphatase 1
-
-
Src homology-2 domain containing protein tyrosine phosphatase-1
-
-
Src homology-2 domain containing protein tyrosine phosphatase-2
-
-
STEP33
-
STEP is processed into a 33 kDa isoform by calpain-mediated cleavage, STEP33 retains catalytic activity but is unable to bind to phosphorylated ERK
STEP46
-
recombinant enzyme
STEP61
-
STEP61 is the normally expressed enzyme form
striatal enriched protein tyrosine phosphatase
-
-
striatal-enriched protein-tyrosine phosphatase
-
-
T cell protein tyrosine phosphatase
-
-
T-cell protein tyrosine phosphatase
T-cell protein-tyrosine phosphatase
-
-
-
testis- and skeletal-muscle-specific DSP
-
-
testis- and skeletal-muscle-specific dual specificity protein phosphatase
-
-
Testis-and skeletal-muscle-specific DSP
-
-
-
tyrosine O-phosphate phosphatase
-
-
-
tyrosine phosphatase alpha
-
-
Tyrosine phosphatase CBPTP
-
-
-
tyrosine phosphatase epsilon
-
-
tyrosine phosphatase IA-2
-
tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1
tyrosine phosphatase-1B
-
tyrosine-protein phosphatase
-
tyrosine-protein phosphatase non-receptor type 22
tyrosine-protein phosphatase non-receptor type 5
UniProt
tyrosine-specific MAPK phosphatase
-
-
tyrosylprotein phosphatase
-
-
-
vaccinia H1-related PTP
-
[phosphotyrosine]protein phosphatase
-
-
-
acid phosphatase

-
Bd1204

-
CAPTPase

-
-
CD148

-
-
CD45

-
-
-
CD45 protein tyrosine phosphatase

-
-
CD45 protein tyrosine phosphatase
-
-
CD45 protein tyrosine phosphatase
-
-
Cdc25A

-
-
Cdc25B

-
-
Cdc25B phosphatase

-
-
Cdc25C

-
-
Ch-1PTPase

-
-
-
CQMa102 phosphatase

-
Cryp-2

-
-
cysteine-dependent protein tyrosine phosphatase

-
-
cysteine-dependent protein tyrosine phosphatase
Yersinia enterolytica
-
-
DEP-1

-
-
dual specificity phosphatase

-
-
dual specificity phosphatase
-
dual-specificity phosphatase

-
dual-specificity phosphatase
-
dual-specificity phosphatase
-
dual-specificity phosphatase
-
DUSP

-
EhPRL

-
HD-PTP

-
-
HEPTP

-
-
-
HEPTP
HePTP negatively regulates T cell activation and proliferation
His domain protein tyrosine phosphatase

-
His domain protein tyrosine phosphatase
-
-
LAR

-
-
LAR
-
member of the R2A subtype of receptor-like PTPs
leucocyte common antigen-related protein tyrosine phosphatase

-
-
leucocyte common antigen-related protein tyrosine phosphatase
-
-
leucocyte common antigen-related protein tyrosine phosphatase
-
-
LMJF_16_0230

-
LmPRL-1

-
LMW PTPase

-
LMW-PTP

-
-
LMWPTP

Streptococcus pneumoniae serotype 2
-
Low molecular weight phosphotyrosine protein phosphatase

UniProt
Low molecular weight phosphotyrosine protein phosphatase
UniProt
low molecular weight protein tyrosine phosphatase

-
low molecular weight protein tyrosine phosphatase
Streptococcus pneumoniae serotype 2
-
low molecular weight protein tyrosine phosphatase
Streptococcus pneumoniae serotype 2 D39
-
low molecular weight protein tyrosine phosphatase
Streptococcus pneumoniae serotype 2 NCTC 7466
-
low molecular weight protein tyrosine phosphatase
-
low molecular weight protein tyrosine phosphatase
-
-
low-molecular weight PTPase

-
low-molecular weight PTPase
-
low-molecular weight PTPase
-
low-molecular-weight protein tyrosine phosphatase

-
low-molecular-weight protein tyrosine phosphatase
-
LyP

-
-
-
MKP-3

-
trivial names Pyst1, rVH6
MKP-4

-
trivial name Pyst3
MKP-5

-
trivial names M3/6, hVH5, HB5
MPtpA

-
-
NC-PTPCOM1

-
-
-
non-receptor protein tyrosine phosphatase

-
-
non-receptor protein tyrosine phosphatase
-
-
orphan protein tyrosine phosphatase

-
orphan protein tyrosine phosphatase
-
orphan protein tyrosine phosphatase
-
OST-PTP

-
-
-
PCPTP1

UniProt
Pmp1p

-
-
PRL

-
PRL-1

-
probable low molecular weight protein-tyrosine-phosphatase

UniProt
probable low molecular weight protein-tyrosine-phosphatase
UniProt
probable low molecular weight protein-tyrosine-phosphatase
UniProt
protein tyrosine phosphatase

-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
-
678028, 678471, 678485, 682756, 692320, 692322, 692448, 693564, 694112, 694163, 694902, 694911, 709433, 709455, 709960, 710028, 710166, 714237, 714323, 714721, 715714, 728947, 729298
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
Streptococcus pneumoniae serotype 2
-
protein tyrosine phosphatase
Streptococcus pneumoniae serotype 2 D39
-
protein tyrosine phosphatase
Streptococcus pneumoniae serotype 2 NCTC 7466
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
Yersinia enterolytica
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase 1B

-
-
679201, 691305, 693564, 693715, 694291, 694525, 694608, 707666, 707675, 707683, 707688, 708290, 709166, 709254, 709293, 710237, 714433, 729368, 729393, 730540, 730564
protein tyrosine phosphatase 1B
-
707634, 708122, 709102, 729379, 730324, 730789, 749934, 750047, 750305, 750465, 751625
protein tyrosine phosphatase 1B
-
protein tyrosine phosphatase 1B
-
-
protein tyrosine phosphatase 1B
-
-
protein tyrosine phosphatase 1B
-
-
protein tyrosine phosphatase epsilon

-
protein tyrosine phosphatase epsilon
-
-
protein tyrosine phosphatase-1B

-
-
protein tyrosine phosphatase-1B
-
protein tyrosine phosphatase-1B
-
-
protein tyrosine phosphatase-1B
-
-
protein tyrosine phosphatase-1B
-
-
protein-tyrosine phosphatase

-
-
protein-tyrosine phosphatase
-
protein-tyrosine phosphatase
-
protein-tyrosine phosphatase
-
protein-tyrosine phosphatase
-
-
protein-tyrosine phosphatase
-
-
protein-tyrosine phosphatase
-
-
protein-tyrosine phosphatase
-
protein-tyrosine phosphatase
-
protein-tyrosine phosphatase
-
protein-tyrosine phosphatase
-
protein-tyrosine phosphatase
-
protein-tyrosine phosphatase
-
protein-tyrosine phosphatase
-
protein-tyrosine phosphatase
-
-
Protein-tyrosine phosphatase 1B

-
-
-
Protein-tyrosine phosphatase 1B
-
-
Protein-tyrosine phosphatase D1

-
-
-
Protein-tyrosine phosphatase D1
-
-
PTEN

-
-
PTK

-
-
PTP

-
-
PTP
-
-
678485, 678831, 691462, 692320, 692322, 692448, 693564, 693943, 694112, 694911, 707688, 709455, 710028, 728947
PTP
Streptococcus pneumoniae serotype 2
-
PTP
Streptococcus pneumoniae serotype 2 D39
-
PTP
Streptococcus pneumoniae serotype 2 NCTC 7466
-
PTP-1B

-
-
-
PTP-BAS

-
-
-
PTP-like phytase

-
PTP-MEG2

-
-
PTP-oc

-
PTP-oc
-
the protein is produced from the distal promotor, PTP-oc is identical to PTPRO, except that its extracellular domain is extremely short with eight amino acids in all
PTP-PEST

-
PTP-PEST
-
a non-receptor protein tyrosine phosphatase
PTP1

-
-
PTP1B

-
-
665520, 678028, 678485, 679201, 691305, 692702, 693564, 693715, 694286, 694291, 694525, 694608, 694902, 707675, 707683, 707688, 708290, 709166, 709254, 709293, 709433, 714237, 714433, 715647, 729298, 729368, 729393, 730540, 730564, 730970
PTP1B
-
664302, 691235, 692320, 709102, 729379, 730324, 730789, 749934, 749953, 750022, 750029, 750047, 750305, 750465, 751130, 751625, 752277
PTP36

-
PtpA

-
-
PTPalpha

-
-
PTPalpha
-
a receptor-type protein-tyrosine phosphatase
PTPase

-
-
PTPase-MEG1

-
-
-
PTPase-MEG2

-
-
-
PtpB

-
-
PTPB1

-
-
PTPbeta

-
PTPBR7

-
membrane isoform
PTPBR7
-
receptor-type isoform
PTPD1

-
PTPD1 is a cytosolic nonreceptor tyrosine phosphatase and a positive regulator of the Src-epidermal growth factor transduction pathway
PTPepsilon

-
PTPepsilon
-
belongs to the receptor-type branch of the PTP family
PTPH1

-
PTPLP

-
PTPN1

-
PTPN11

-
-
PTPN12

-
PTPN14

-
PTPN22

-
-
PTPN23

-
-
PTPN3

-
PTPN3
-
a non-receptor protein tyrosine phosphatase
PTPN4

-
PTPN4
-
a non-receptor protein tyrosine phosphatase
PTPN5

-
-
PTPN5
also called striatal-enriched phosphatase or STEP
PTPN6

-
-
-
PTPN7

-
-
PTPN7
also called hematopoietic PTP
PTPN9

-
PTPRJ

-
-
PTPRO

-
PTPRO
-
a receptor-type PTP, the protein is produced from the distal promotor
PTPRQ

-
PTPRR

-
-
PTPRR
also called PC12 PTP or STEP-like PTP
PTPRT

-
-
Pyp1p

-
-
Pyp2p

-
-
R2B phosphatase

-
-
receptor protein tyrosine phosphatase rho

-
-
receptor protein tyrosine phosphatase rho
-
-
RPTPalpha

-
-
-
RPTPepsilon

-
RPTPepsilon
-
receptor-type isoform of PTPepsilon
RPTPkappa

-
-
RPTPrho/PTPRT

-
-
Saci-PTP

dual specific phosphatase EC 3.1.3.16/EC 3.1.3.48
Saci-PTP
dual specific phosphatase EC 3.1.3.16/EC 3.1.3.48
Saci0545

locus name, dual specific phosphatase EC 3.1.3.16/EC 3.1.3.48
Saci0545
locus name, dual specific phosphatase EC 3.1.3.16/EC 3.1.3.48
SHP-1

-
-
SHP-1
-
also known as PTP1C and SH-PTP1
SHP-1
-
SHP-1 is a nontransmembrane PTP
SHP-1
-
also known as PTP1C and SH-PTP1
SHP-2

-
-
SHP-2
-
also known as PTP1D and SH-PTP2
SHP-2
-
also known as PTP1D and SH-PTP2
SHP1

-
-
SHP2

-
-
SHP2
-
Shp2 is a nonreceptor PTP that plays a positive role in cell signaling by growth factors and cytokines and is involved in regulation of cell proliferation, differentiation, and migration
Siw14

-
-
Spd1837

Streptococcus pneumoniae serotype 2
-
Spd1837
Streptococcus pneumoniae serotype 2 D39
-
Spd1837
Streptococcus pneumoniae serotype 2 NCTC 7466
-
SPD_1837

Streptococcus pneumoniae serotype 2
-
SPD_1837
Streptococcus pneumoniae serotype 2 D39
-
SPD_1837
Streptococcus pneumoniae serotype 2 NCTC 7466
-
SPy_0036

-
STEP

-
-
-
Stp1

-
striatal-enriched PTP

-
-
striatal-enriched PTP
-
-
T-cell protein tyrosine phosphatase

-
-
T-cell protein tyrosine phosphatase
-
-
T-cell protein tyrosine phosphatase
-
-
T-cell PTP

-
-
TCPTP

-
-
-
TcPTP1

-
-
TpbA

-
tyrosine phosphatase

-
-
tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1

-
-
tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1
-
-
tyrosine-protein phosphatase non-receptor type 22

UniProt
tyrosine-protein phosphatase non-receptor type 22
UniProt
VHR

-
-
YopH

-
YopH
Yersinia enterolytica
-
-
additional information

cf. EC 3.1.3.16
additional information
-
CRYP-2 is identical in sequence to the human glomerular epithelial protein-1
additional information
-
SHP-1 belongs to the family of non-receptor protein tyrosine phosphatases
additional information
ED-Eya2 belongs to the haloacid dehalogenase family
additional information
the enzyme belongs to the LMW-PTP family
additional information
cf. EC 3.1.3.16
additional information
cf. EC 3.1.3.16
additional information
-
SHP-1 is a member of SH2 domain-containing PTP subfamily
additional information
-
the enzyme is a member of the PTP family
additional information
cf. EC 3.1.3.56
additional information
cf. EC 3.1.3.56
additional information
cf. EC 3.1.3.16
additional information
cf. EC 3.1.3.16
additional information
cf. EC 3.1.3.16
additional information
cf. EC 3.1.3.16
additional information
cf. EC 3.1.3.16
additional information
cf. EC 3.1.3.16
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[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate

mechanism
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
activation mechanism
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
comparison of kinetic properties of different transmembrane and cytosolic isozymes
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, features required for substrate
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, kinetic isotope effects
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, role of residue 182
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, transition state of reaction, kinetic isotope effects, overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
overview on mechanism and transition state
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
overview on mechanism and transition state
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
overview on mechanism and transition state
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
thermodynamic parameters
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
arrangement of two metal ions, a phosphate ion, and amino acid residues in the catalytic site is identical to that of PS/Tpases
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
conformation of active site is favorable for phosphotyrosine binding. Interaction of D115 and R13 to stabilize the conformation of the active cavity. A41 and G45 form a noncharged surface around the active cavity, which is surrounded by a flexible wall made of the loop region from F40 to T48
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
H148 acts as a general acid catalyst, D115 assists the protonation of the leaving group of a substrate, and D76 and D112 are involved in binding of magnesium ions
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
in addition to active site, enzyme has a low-affinity noncatalytic aryl phosphate-binding site
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
motif H74C(X)5R81 is involved in catalysis
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
ping-pong mechanism, catalysis proceeds through a two-step mechanism involving a phosphocysteine intermediate. In the first step, a nucleophilic cysteine thiolate attacks the phosphate ester moiety of the substrate, resulting in formation of a phosphoenzyme intermediate with release of the peptidyl tyrosine. The second step occurs via attack of water on the phosphoenzyme intermediate, and yields the final products inorganic phosphate and the regenerated enzyme. The central binding site for the substrate is the P-loop, a region at the bottom of a pocket that includes the nucleophilic cysteine and backbone amide groups oriented in a horseshoe fashion, catalytic cycle, detailed overview
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism of the dephosphorylation catalysed by MptpA
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
the phosphatase domain of PTPRs catalyze a two-step phosphate monoester hydrolysis reaction through a highly conserved sequence motif (H/V)CX5R(S/T) with a nucleophilic cysteine
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
-
-
-
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1-naphthyl phosphate + H2O
1-naphthol + phosphate
1-naphthyl phosphate + H2O
?
-
-
?
3,6-fluorescein diphosphate + H2O
? + phosphate
-
-
?
3-nitrobenzyl phosphate + H2O
3-nitrobenzyl alcohol + phosphate
-
-
-
?
3-o-methyl fluorescein phosphate + H2O
3-o-methyl fluorescein + phosphate
3-O-methylfluorescein phosphate + H2O
3-O-methylfluorescein + phosphate
-
-
-
?
4-methylumbelliferyl phosphate + H2O
4-methylumbelliferone + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + H2O
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
4-nitrophenyl phosphate + H2O
4-nitrophenyl + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
nitrophenol + phosphate
4-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
-
-
?
4-nitrophenylphosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferol + phosphate
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferone + phosphate
AAAAApYEEVH + H2O
AAAAAYEEVH + phosphate
-
substrate of RPTPalpha
-
?
AAAAApYRHRR + H2O
AAAAAYRHRR + phosphate
-
substrate of RPTPalpha
-
?
Ac-AAAApYAAAA-NH2 + H2O
Ac-AAAAYAAAA-NH2 + phosphate
-
-
-
?
Ac-AAAEpYAAAA-NH2 + H2O
Ac-AAAEYAAAA-NH2 + phosphate
-
-
-
?
Ac-AAAQpYAAAA-NH2 + H2O
Ac-AAAQYAAAA-NH2 + phosphate
-
-
-
?
Ac-DGEEpYDDPF-NH2 + H2O
Ac-DGEEYDDPF-NH2 + phosphate
-
SKAP-HOM Tyr75 peptide
-
?
Ac-ENDEpYTARE-NH2 + H2O
Ac-ENDEYTARE-NH2 + phosphate
-
Lck Tyr394 peptide
-
?
Ac-TEPQpYQPGE-NH2 + H2O
Ac-TEPQYQPGE-NH2 + phosphate
-
Lck Tyr505 peptide
-
?
Ac-YGEEpYDDLY-NH2 + H2O
Ac-YGEEYDDLY-NH2 + phosphate
-
consensus peptide 1
-
?
Ac-YGYEpYDDEY-NH2 + H2O
Ac-YGYEYDDEY-NH2 + phosphate
-
consensus peptide 2
-
?
acetyl-DADEpY-NH2 + H2O
acetyl-DADEY-NH2 + phosphate
-
-
-
?
acetyl-DADEpYL-NH2 + H2O
acetyl-DADEYL-NH2 + phosphate
-
-
?
ADEDFpYAA + H2O
ADEDFYAA + phosphate
-
substrate of SHP-2
-
?
AKFEDTpYAA + H2O
AKFEDTYAA + phosphate
-
substrate of SHP-1
-
?
angiotensin I + H2O
? + phosphate
-
-
-
?
ApYR + H2O
AYR + phosphate
-
-
-
?
ARKRIpYAA + H2O
ARKRIYAA + phosphate
-
substrate of RPTPalpha
-
?
ASSDDpYAA + H2O
ASSDDYAA + phosphate
-
substrate of RPTPalpha
-
?
ATP + H2O
ADP + phosphate
AVWEFpYpYAA + H2O
? + phosphate
-
substrate of SHP-1
-
?
AWSpYADpYAA + H2O
? + phosphate
-
substrate of SHP-1
-
?
AYTEpYTpYAA + H2O
? + phosphate
-
substrate of SHP-1
-
?
beta-naphthyl phosphate + H2O
beta-naphthol + phosphate
-
-
-
?
bis(4-nitrophenyl) phosphate + H2O
?
-
-
?
bis-(p-phosphophenyl) methane + H2O
?
synthetic high-affinity low-molecular weight nonpeptide substrate
-
?
bovine serum albumin + H2O
? + phosphate
carboxyamidomethylated and maleylated lysozyme + H2O
?
-
-
-
?
carrier protein-Cdc2-phosphotyrosine + H2O
carrier protein-Cdc2-tyrosine + phosphate
-
-
-
?
carrier protein-Y3-phosphotyrosine + H2O
carrier protein-Y3-tyrosine + phosphate
-
-
-
?
carrier protein-Y5-phosphotyrosine + H2O
carrier protein-Y5-tyrosine + phosphate
-
-
-
?
casein tyrosine phosphate + H2O
casein tyrosine + phosphate
-
-
-
?
Cdk2-pTpY + H2O
Cdk2-TpY + phosphate
-
dephosphorylates Cdk/cyclins on pThr14 and/or pTyr15 residues
-
?
Cdk2-pTpY/CycA + H2O
Cdk2-pTY/CycA + phosphate
-
-
-
?
D-fructose 1,6-diphosphate + H2O
?
DADE(pY)LIPQQG + H2O
DADEYLIPQQG + phosphate
DADEpYIPQQG + H2O
DADEYIPQQG + phosphate
DADEpYLIPQQG + H2O
DADEYLIPQQG + phosphate
DAEDFpYAA + H2O
DAEDFYAA + phosphate
-
substrate of SHP-2
-
?
DDT-(3,5-difluoro)YDpYAA + H2O
DDT-(3,5-difluoro)YDYAA + phosphate
-
-
-
?
DDTYDpYAA + H2O
DDTYDYAA + phosphate
-
-
-
?
DFEDFpYAA + H2O
DFEDFYAA + phosphate
-
substrate of SHP-2
-
?
difluoromethylumbelliferyl phosphate + H2O
difluoromethylumbelliferone + phosphate
-
-
?
DNL-(3,5-difluoro)YpYWD + H2O
DNL-(3,5-difluoro)YYWD + phosphate
-
-
-
?
DNLYpYWD + H2O
DNLYYWD + phosphate
-
-
-
?
DRVpYIHPFHL + H2O
DRVYIHPFHL + phosphate
-
-
?
DWEDFpYAA + H2O
DWEDFYAA + phosphate
-
substrate of SHP-2
-
?
EADTApYAA + H2O
EADTAYAA + phosphate
-
substrate of RPTPalpha
-
?
EIFDFpYAA + H2O
EIFDFYAA + phosphate
-
substrate of SHP-1 and SHP-2
-
?
END(pY)INASL + H2O
ENDYINASL + phosphate
ENDpYINASL + H2O
ENDYINASL + phosphate
ENPE(pY)LGLD + H2O
ENPEYLGLD + phosphate
dephosphorylation at Tyr1248
-
?
ENPE(pY)LTPQ + H2O
ENPEYLTPQ + phosphate
dephosphorylation at Tyr1196
-
?
EphA3-phosphotyrosine + H2O
EphA3-tyrosine + phosphate
-
-
-
?
epidermal growth factor + H2O
? + phosphate
-
-
-
?
epidermal growth factor receptor + H2O
? + phosphate
-
with phosphotyrosine Tyr992
-
?
fatty acid binding protein + H2O
? + phosphate
-
i.e. ppI5
-
?
FDEDFpYAA + H2O
FDEDFYAA + phosphate
-
substrate of SHP-2
-
?
FDIDIpYAA + H2O
FDIDIYAA + phosphate
-
substrate of SHP-1 and SHP-2
-
?
FDNL(pY)2WDQD + H2O
FDNLYYWDQD + 2 phosphate
dephosphorylation at Tyr1221/1222
-
?
fluorescein diphosphate + H2O
?
-
-
-
?
fluorescein diphosphate + H2O
fluorescein phosphate + phosphate
-
-
-
?
FMN + H2O
?
-
lung enzyme
-
?
FMN + H2O
? + phosphate
-
71.8% of the activity with 4-nitrophenyl phosphate, lung enzyme
-
?
FYDIDpYAA + H2O
FYDIDYAA + phosphate
-
substrate of SHP-1 and SHP-2
-
?
Gab1 tyrosine phosphate + H2O
Gab1 tyrosine + phosphate
-
-
-
?
gastrin + H2O
? + phosphate
-
phosporylated on tyrosine
-
?
GESDGGpYMDMSKD + H2O
GESDGGYMDMSKD + phosphate
-
this peptide corresponds to the sequence containing Tyr740 of the human platelet-derived growth factor receptor
-
?
GNGDpYMPMSPKS + H2O
GNGDYMPMSPKS + phosphate
-
-
-
?
hirudin + H2O
? + phosphate
-
hirudin from leech, phosporylated on tyrosine
-
?
human A431 membrane protein + H2O
? + phosphate
inositol hexakisphosphate + H2O
?
highest activity
-
?
insulin receptor phosphopeptide + H2O
insulin receptor peptide + phosphate
insulin-like growth factor-1 + H2O
? + phosphate
-
-
-
?
KRLIEDNE(pY)TARGQ + H2O
KRLIEDNEYTARGQ + phosphate
-
phosphopeptide derived from autophosphorylation of mammalian tyrosine kinase Lck
-
?
LDEpYVATR + H2O
LDEYVATR + phosphate
-
-
?
LIEDNEpYTARQGA + H2O
LIEDNEYTARQGA + phosphate
-
substrate of RPTPalpha
-
?
lysozyme + H2O
? + phosphate
-
reduced, carboxymethylated and maleylated
-
?
membrane protein 3 + H2O
? + phosphate
-
-
-
?
myelin basic protein + H2O
?
-
-
-
?
myelin basic protein + H2O
? + phosphate
-
-
-
?
myosin P-light chain + H2O
? + phosphate
-
-
-
?
n-nitrophenyl phosphate + H2O
n-nitrophenol + phosphate
-
-
-
?
nicotinic acetylcholine receptor + H2O
?
-
i.e. nAChR
-
?
nicotinic acetylcholine receptor + H2O
? + phosphate
-
i.e. nAChR
-
?
NKpYGN + H2O
NKYGN + phosphate
-
-
-
?
O-phospho-L-serine + H2O
L-serine + phosphate
-
very low activity with
-
?
O-phospho-L-threonine + H2O
L-threonine + phosphate
-
-
-
?
O-phospho-L-tyrosine + H2O
?
-
-
?
O-phospho-L-tyrosine + H2O
L-tyrosine + phosphate
O-phospho-L-tyrosine + H2O
tyrosine + phosphate
p-nitrophenyl phosphate
p-nitrophenol + phosphate
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
p120ctn + H2O
120ctn + phosphate
paxilin tyrosine phosphate + H2O
paxilin tyrosine + phosphate
PGSAAP-pY-LKTKFI + H2O
PGSAAPYLKTKFI + phosphate
STAT3 peptide
-
?
phenolphthalein diphosphate + H2O
?
-
-
?
phenyl phosphate + H2O
phenol + phosphate
-
-
-
?
phosphocaveolin-1 + H2O
caveolin-1 + phosphate
-
phosphorylated at Y14
-
?
phosphoprotein + H2O
protein + phosphate
-
-
-
?
phosphorylated Abelson interacting protein + H2O
Abelson interacting protein + phosphate
-
-
-
?
phosphorylated Abl tyrosine kinase + H2O
Abl tyrosine kinase + phosphate
-
-
-
?
phosphorylated Ack protein + H2O
Ack protein + phosphate
-
-
-
?
phosphorylated actin + H2O
actin + phosphate
-
-
-
?
phosphorylated adenomatous Polyposis coli-protein + H2O
adenomatous Polyposis coli-protein + phosphate
-
-
-
?
phosphorylated alpha-actinin + H2O
alpha-actinin + phosphate
-
-
-
?
phosphorylated AMP-activated protein kinase + H2O
AMP-activated protein kinase + phosphate
phosphorylated BCAR3 + H2O
BCAR3 + phosphate
-
-
-
?
phosphorylated BCR-Abl + H2O
BCR-Abl + phosphate
-
-
?
phosphorylated c-Kit + H2O
c-Kit + phosphate
-
dephosphorylation occurs at tyrosines 567/569 and 719
-
?
phosphorylated c-MET + H2O
c-MET + phosphate
phosphorylated c-Src + H2O
c-Src + phosphate
phosphorylated CD3 epsilon + H2O
CD3 epsilon + phosphate
-
-
-
?
phosphorylated Cdk2-pTpY/CycA protein + H2O
Cdk2-pTpY/CycA protein + phosphate
-
-
?
phosphorylated colony-stimulating factor 1 receptor + H2O
colony-stimulating factor 1 + phosphate
-
-
-
?
phosphorylated Down syndrome cell adhesion molecule + H2O
Down syndrome cell adhesion molecule + phosphate
-
-
-
?
phosphorylated E-cadherin + H2O
E-cadherin + phosphate
phosphorylated EphA2 receptor + H2O
EphA2 receptor + phosphate
-
-
-
?
phosphorylated EphA5 + H2O
EphA5 + phosphate
-
-
-
?
phosphorylated epidermal growth factor receptor + H2O
epidermal growth factor receptor + phosphate
phosphorylated ErbB1 + H2O
ErbB1 + phosphate
-
-
-
?
phosphorylated ErbB2 + H2O
ErbB2 + phosphate
-
-
-
?
phosphorylated ERK + H2O
ERK + phosphate
phosphorylated ERK1 + H2O
ERK1 + phosphate
-
-
?
phosphorylated ERK2 + H2O
ERK2 + phosphate
HePTP binds the phosphorylated tyrosine of the Erk2 peptide (pY185), Erk2 residue T183, which is phosphorylated in maximally activated Erk2, is not essential for substrate recognition and binding by HePTP
-
?
phosphorylated eukaryotic-initiation-factor-4G + H2O
eukaryotic-initiation-factor-4G + phosphate
-
-
-
?
phosphorylated extracellular signal regulated kinase + H2O
extracellular signal regulated kinase + phosphate
-
-
-
?
phosphorylated extracellular signal-regulated kinase 1 + H2O
extracellular signal-regulated kinase 1 + phosphate
phosphorylated extracellular signal-regulated kinase 2 + H2O
extracellular signal-regulated kinase 2 + phosphate
phosphorylated Ezrin + H2O
Ezrin + phosphate
-
-
-
?
phosphorylated focal adhesion kinase + H2O
focal adhesion kinase + phosphate
-
dephosphorylation occurs at Tyr-397, PTPD1 activity is required for focal adhesion kinase autophosphorylation and adhesion plaque stability
-
?
phosphorylated fragile X related + H2O
fragile X related + phosphate
-
-
-
?
phosphorylated Gln3 + H2O
Gln3 + phosphate
-
Siw14, in combination with the protein kinase Npr1, regulates the intracellular localization of Gln3
-
?
phosphorylated HEM protein + H2O
HEM protein + phosphate
-
-
-
?
phosphorylated hepatocyte growth factor regulated tyrosine kinase substrate + H2O
hepatocyte growth factor regulated tyrosine kinase substrate + phosphate
-
-
-
?
phosphorylated Hsc-70-4 + H2O
Hsc-70-4 + phosphate
-
-
-
?
phosphorylated IGF-I receptor + H2O
IGF-I receptor + phosphate
-
isozyme p52shc
-
?
phosphorylated IGF-II mRNA-binding protein + H2O
IGF-II mRNA-binding protein + phosphate
-
-
-
?
phosphorylated insulin receptor + H2O
insulin receptor + phosphate
phosphorylated insulin receptor substrate-1 + H2O
insulin receptor substrate-1 + phosphate
-
-
-
?
phosphorylated insulin receptor substrate-2 + H2O
insulin receptor substrate-2 + phosphate
-
-
-
?
phosphorylated JAK2 + H2O
JAK2 + phosphate
-
SHP2 dephosphorylates the Tyr1007 site, preventing the formation of the JAK2-Socs1 complex
-
?
phosphorylated Janus kinase 2 + H2O
Janus kinase 2 + phosphate
phosphorylated JNK + H2O
JNK + phosphate
-
-
?
phosphorylated Jun amino-terminal kinase + H2O
Jun amino-terminal kinase + phosphate
-
-
-
?
phosphorylated Lasp protein + H2O
Lasp protein + phosphate
-
-
-
?
phosphorylated Lck + H2O
Lck + phosphate
-
component of the T cell receptor signaling pathway
-
?
phosphorylated mitogen-activated protein kinase + H2O
mitogen-activated protein kinase + phosphate
-
-
-
?
phosphorylated mitogen-activated protein kinase Pmk1p + H2O
mitogen-activated protein kinase Pmk1p + phosphate
phosphorylated Munc18c + H2O
Munc18c + phosphate
-
dephosporylation at Tyr218/219 and Tyr521
-
?
phosphorylated p130 Crk-associated substrate + H2O
p130 Crk-associated substrate + phosphate
-
-
-
?
phosphorylated p130Cas + H2O
p130Cas + phosphate
-
-
-
?
phosphorylated p190B Rho-GTPase-activating protein + H2O
p190B Rho-GTPase-activating protein + phosphate
-
-
-
?
phosphorylated p38 mitogen-activated protein kinase + H2O
p38 mitogen-activated protein kinase + phosphate
phosphorylated p85
p85 + phosphate
-
-
-
?
phosphorylated PDGF- and VEGF-receptor related + H2O
PDGF- and VEGF-receptor related + phosphate
-
-
-
?
phosphorylated phospholipase Cgamma + H2O
phospholipase Cgamma + phosphate
phosphorylated platelet-derived growth factor receptor + H2O
platelet-derived growth factor receptor + phosphate
-
-
-
?
phosphorylated poly(A)-binding protein + H2O
poly(A)-binding protein + phosphate
-
-
-
?
phosphorylated polychaetoid + H2O
polychaetoid + phosphate
-
-
-
?
phosphorylated proline serine threonine-rich phosphatase interacting protein + H2O
proline serine threonine-rich phosphatase interacting protein + phosphate
-
-
-
?
phosphorylated proline-rich tyrosine kinase 2 + H2O
proline-rich tyrosine kinase 2 + phosphate
-
the enzyme directly binds to and dephosphorylates proline-rich tyrosine kinase 2 at Tyr402
-
?
phosphorylated protein kinase-like endoplasmic reticulum kinase + H2O
protein kinase-like endoplasmic reticulum kinase + phosphate
-
dephosphorylation at Tyr615
-
?
phosphorylated protein p85
protein p85 + phosphate
-
-
-
?
phosphorylated pyruvate kinase M2 + H2O
pyruvate kinase M2 + phosphate
-
-
-
?
phosphorylated rasputin + H2O
rasputin + phosphate
-
-
-
?
phosphorylated RET(C634R) oncoprotein + H2O
RET(C634R) oncoprotein + phosphate
-
dephosphorylation at Tyr905 and Tyr1062
-
?
phosphorylated RET-MEN2A oncoprotein + H2O
RET-MEN2A oncoprotein + phosphate
-
dephosphorylation at Tyr905 and Tyr1062
-
?
phosphorylated RET/PTC1 oncoprotein + H2O
RET/PTC1 oncoprotein + phosphate
-
dephosphorylation at Tyr905 and Tyr1062
-
?
phosphorylated RhoGAP15B + H2O
RhoGAP15B + phosphate
-
-
-
?
phosphorylated SCAR + H2O
SCAR + phosphate
-
-
-
?
phosphorylated SH3PX1 + H2O
SH3PX1 + phosphate
-
-
-
?
phosphorylated Shc protein + H2O
Shc protein + phosphate
-
-
-
?
phosphorylated signal transducer and activator of transcription 3 + H2O
signal transducer and activator of transcription 3 + phosphate
-
-
-
?
phosphorylated specifically Rac1-associated protein 1 + H2O
specifically Rac1-associated protein 1 + phosphate
-
-
-
?
phosphorylated Src + H2O
Src + phosphate
phosphorylated Src protein + H2O
Src protein + phosphate
-
-
-
?
phosphorylated Src tyrosine kinase + H2O
Src tyrosine kinase + phosphate
-
PTPD1 associates with and activates Src tyrosine kinase
-
?
phosphorylated STAT1 + H2O
STAT1 + phosphate
phosphorylated STAT1c + H2O
STAT1c + phosphate
phosphorylated STAT3 + H2O
STAT3 + phosphate
phosphorylated STAT5 + H2O
STAT5 + phosphate
-
purified SHP2 protein directly dephosphorylates STAT5 or tyrosine-phosphorylated peptides derived from STAT5
-
?
phosphorylated T cell antigen receptor chain zeta + H2O
T cell antigen receptor chain zeta + phosphate
-
-
-
?
phosphorylated T cell antigen receptor zeta + H2O
T cell antigen receptor zeta + phosphate
-
-
-
?
phosphorylated T-cell receptor-zeta subunit + H2O
T-cell receptor-zeta subunit + phosphate
-
dephosphorylates ITAMs of the T-cell receptor-zeta subunit
-
?
phosphorylated TCRzeta + H2O
TCRzeta + phosphate
-
PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway
-
?
phosphorylated valosin containing protein + H2O
valosin containing protein + phosphate
-
-
-
?
phosphorylated vascular endothelial growth factor receptor 2 + H2O
vascular endothelial growth factor receptor 2 + phosphate
phosphorylated Vav + H2O
Vav + phosphate
-
component of the T cell receptor signaling pathway
-
?
phosphorylated voltage-gated potassium channel subunit Kv2.1 + H2O
voltage-gated potassium channel subunit Kv2.1 + phosphate
-
-
-
?
phosphorylated Y527-phosphorylated Src + H2O
Src + phosphate
-
-
-
?
phosphorylated YwqD
YwqD + phosphate
-
protein implicated in UDP-glucuronate synthesis
-
?
phosphorylated YwqF
YwqF + phosphate
-
protein implicated in UDP-glucuronate synthesis
-
?
phosphorylated ZAP-70 + H2O
ZAP-70 + phosphate
-
-
-
?
phosphorylated Zap70 + H2O
Zap70 + phosphate
-
protein-tyrosine kinase
-
?
phosphoserine + H2O
serine + phosphate
-
-
-
?
phosphothreonine + H2O
threonine + phosphate
phosphotyrosine + H2O
tyrosine + phosphate
phosphotyrosine serum albumin + H2O
? + phosphate
phosphotyrosyl bovine serum albumin + H2O
tyrosyl-bovine serum albumin + phosphate
-
-
-
?
phosphotyrosyl casein + H2O
tyrosylcasein + phosphate
-
-
-
?
phosphotyrosyl histone + H2O
? + phosphate
-
-
-
?
phosphotyrosyl myelin basic protein + H2O
tyrosyl-myelin basic protein + phosphate
-
-
-
?
phosphotyrosyl reduced carboxyamidomethylated and maleylated lysozyme + H2O
tyrosyl-reduced carboxyamidomethylated and maleylated lysozyme + phosphate
-
-
-
?
phosphotyrosyl-casein + H2O
? + phosphate
phosphotyrosyl-STAT3 + H2O
STAT3 + phosphate
platelet-derived growth factor receptor + H2O
? + phosphate
PLC-gamma1 tyrosine phosphate + H2O
PLC-gamma1 tyrosine + phosphate
-
-
-
?
PLQR(pY)SEDP + H2O
PLQRYSEDP + phosphate
dephosphorylation at Tyr1112
-
?
poly(Glu,Tyr) + H2O
? + phosphate
PQDKEY-pY-KVKEPG + H2O
PQDKEYYKVKEPG + phosphate
JAK2 peptide
-
?
protein FAK + H2O
?
-
-
-
?
protein Shc + H2O
?
-
-
-
?
Raytide peptide + H2O
? + phosphate
-
-
-
?
RE-(3,5-difluoro)YEFpYAA + H2O
RE-(3,5-difluoro)YEFYAA + phosphate
-
-
-
?
REYEFpYAA + H2O
REYEFYAA + phosphate
-
-
-
?
RKGSGD-pY-MPMSPK + H2O
RKGSGDYMPMSPK + phosphate
IRS1 peptide
-
?
RRISTpYAA + H2O
RRISTYAA + phosphate
-
substrate of RPTPalpha
-
?
RRLIEDAEpYAARG + H2O
RRLIEDAEYAARG + phosphate
SASASpYDWEF + H2O
SASASYDWEF + phosphate
-
substrate of SHP-1 and SHP-2
-
?
SASASpYSASA + H2O
SASASYSASA + phosphate
SKAP-HOM + H2O
?
-
a cytosolic adaptor protein required for proper activation of the immune system, a bona fide Lyp substrate
-
?
soluble N-ethylmaleimide-sensitive factor attachment protein receptor + H2O
soluble N-ethylmaleimide-sensitive factor attachment protein receptor + phosphate
-
-
-
?
TATEPQpYQPGEN + H2O
TATEPQYQPGEN + phosphate
-
substrate of RPTPalpha
-
?
TATEPQpYQPGENL + H2O
TATEPQYQPGENL + phosphate
-
substrate of RPTPalpha
-
?
TEVGKRI(pY)RLVGDKN + H2O
TEVGKRIYRLVGDKN + phosphate
TGFLTELpYVATRWY + H2O
TGFLTELYVATRWY + phosphate
-
this peptide corresponds to the sequence containing Tyr204 of the human extracellular signal-regulated kinase
-
?
TRDIpYETDYYRK + H2O
TRDIYETDYYRK + phosphate
TSTEPQpYQPGENL + H2O
TSTEPQYQPGENL + phosphate
tyrosin kinase + H2O
? + phosphate
-
-
-
?
tyrosine-phosphorylated myelin basic protein + H2O
myelin basic protein + phosphate
-
-
-
?
tyrosine-phosphorylated Raytide + H2O
Raytide + phosphate
-
-
-
?
WAGDDpYAA + H2O
WAGDDYAA + phosphate
-
substrate of SHP-1 and SHP-2
-
?
WDEDFpYAA + H2O
WDEDFYAA + phosphate
-
substrate of SHP-2
-
?
WDEDFpYDWEF + H2O
WDEDFYDWEF + phosphate
-
substrate of SHP-1 and SHP-2
-
?
WDEDFpYRWKF + H2O
WDEDFYRWKF + phosphate
-
substrate of SHP-1 and SHP-2
-
?
WDEDFpYSASA + H2O
WDEDFYSASA + phosphate
WRKRFpYDWEF + H2O
WRKRFYDWEF + phosphate
-
substrate of SHP-1 and SHP-2
-
?
YCRPESQEHPEADPGAAPpYLK + H2O
YCRPESQEHPEADPGAAYLK + phosphate
-
YCRPESQEHPEADPGAApYLK is signal transducer and activator of transcription 3, is dephosphorylated at Y705
-
?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
[ATP synthase]-tyrosine phosphate + H2O
[ATP synthase]-tyrosine + phosphate
[casein]-tyrosine phosphate + H2O
[casein]-tyrosine + phosphate
-
-
?
[cytosolic 6-phosphofructokinase]-tyrosine phosphate + H2O
[cytosolic 6-phosphofructokinase]-tyrosine + phosphate
[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
[EGF receptor]-tyrosine1018 phosphate + H2O
[EGF receptor]-tyrosine1018 + phosphate
highest activity
-
?
[epidermal growth factor receptor 2]-tyrosine phosphate + H2O
[epidermal growth factor receptor 2]-tyrosine + phosphate
dephosphorylation of epidermal growth factor receptor 2 (HER2)-pY1196 site
-
?
[epidermal growth factor receptor]-tyrosine phosphate + H2O
[epidermal growth factor receptor]-tyrosine + phosphate
[Eps15 peptide846-854 P850V]-tyrosine phosphate + H2O
[Eps15 peptide846-854 P850V]-tyrosine + phosphate
-
-
?
[Eps15 peptide846-854]-tyrosine phosphate + H2O
[Eps15 peptide846-854]-tyrosine + phosphate
[Eps15 peptide]-tyrosine phosphate + H2O
[Eps15 peptide]-tyrosine + phosphate
[FAK]-tyrosine phosphate + H2O
[FAK]-tyrosine + phosphate
dephosphorylation at Tyr397
-
?
[FHA-1]-tyrosine phosphate + H2O
[FHA-1]-tyrosine + phosphate
[FYN kinase]-tyrosine phosphate + H2O
[FYN kinase]-tyrosine + phosphate
-
-
?
[HER2]-tyrosine phosphate + H2O
[HER2]-tyrosine + phosphate
dephosphorylation at Tyr1112, Tyr1196, Tyr1221, Tyr1222, and Tyr1248
-
?
[insulin receptor kinase]-tyrosine phosphate + H2O
[insulin receptor kinase]-tyrosine + phosphate
-
-
?
[myelin basic protein]-tyrosine phosphate + H2O
[myelin basic protein]-tyrosine + phosphate
-
-
?
[p130Cas]-tyrosine phosphate + H2O
[p130Cas]-tyrosine + phosphate
dephosphorylation at Tyr165
-
?
[p190RhoGAP]-tyrosine phosphate + H2O
[p190RhoGAP]-tyrosine + phosphate
dephosphorylation at Tyr1105
-
?
[paxillin]-tyrosine phosphate + H2O
[paxillin]-tyrosine + phosphate
dephosphorylation at Tyr118
-
?
[protein Golgi p230]-tyrosine phosphate + H2O
[protein Golgi p230]-tyrosine + phosphate
[protein]-L-tyrosine phosphate + H2O
[protein]-L-tyrosine + phosphate
[protein]-tyrosine phosphate + H2O
[protein]-tyrosine + phosphate
[SRC]-tyrosine phosphate + H2O
[SRC]-tyrosine + phosphate
dephosphorylation at Tyr416
-
?
[sulfide quinone oxidoreductase]-tyrosine phosphate + H2O
[sulfide quinone oxidoreductase]-tyrosine + phosphate
[trifunctional enzyme]-tyrosine phosphate + H2O
[trifunctional enzyme]-tyrosine + phosphate
[VAV2]-tyrosine phosphate + H2O
[VAV2]-tyrosine + phosphate
dephosphorylation at Tyr172
-
?
additional information
?
-
1-naphthyl phosphate + H2O

1-naphthol + phosphate
-
89.3% of the activity with 4-nitrophenyl phosphate, lung enzyme
-
?
1-naphthyl phosphate + H2O
1-naphthol + phosphate
-
-
-
?
3-o-methyl fluorescein phosphate + H2O

3-o-methyl fluorescein + phosphate
-
-
?
3-o-methyl fluorescein phosphate + H2O
3-o-methyl fluorescein + phosphate
-
-
?
3-o-methyl fluorescein phosphate + H2O
3-o-methyl fluorescein + phosphate
-
-
?
4-nitrophenyl phosphate + H2O

4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
663621, 665502, 692217, 693943, 694291, 694608, 694902, 707683, 708290, 709293, 710237, 729298, 729368, 729393, 730564, 730970 -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate