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Information on EC 3.1.3.48 - protein-tyrosine-phosphatase
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EC Tree
3.1.3.48 protein-tyrosine-phosphataseIUBMB Comments
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
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Word Map
- 3.1.3.48
- pp2a
- diabetes
- mapks
- cytokine
- autoimmune
- cyclin
- bone
- erk
- adhesion
- leukemia
- endothelial
- t-cells
- breast
- ras
- lysosomal
-
signal-regulated
-
checkpoint
-
okadaic
- myeloid
- orthovanadate
- stat3
- phosphatidylinositol
- arthritis
-
tyrosine-phosphorylated
-
cyclin-dependent
- adaptor
- 3-kinase
- vanadate
-
hyperphosphorylation
- pkc
- genistein
- autophosphorylation
-
rheumatoid
- c-jun
-
receptor-like
- chk1
-
nonreceptor
-
cytochemical
- grb2
- c-src
-
insulin-stimulated
- irs-1
- fyn
- phosphopeptide
-
tartrate-resistant
- jak2
-
myelomonocytic
- substrate-1
-
polo-like
- paxillin
- drug development
- medicine
- pharmacology
- diagnostics
The enzyme appears in viruses and cellular organisms
Synonyms
70Z-SHP, acid phosphatase, acid phosphatase activity, acid phosphatase ortholog, acid tyrosine phosphatase, alpha-PTP-PEST, AUM, Bd1204, BDP, Bmptp-h, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
70Z-SHP
-
-
-
-
acid phosphatase
acid phosphatase ortholog
-
the enzyme share the conserved RHGXRXP motif characteristic of the histidine acid phosphatase family
Bd1204
Brain-derived phosphatase
-
-
-
-
BVP
-
-
-
-
CAPTPase
CD148
CD148 antigen
-
-
-
-
CD45
CD45 antigen
-
-
-
-
CD45 protein tyrosine phosphatase
Cdc25-like protein
-
-
-
-
Cdc25A
Cdc25B
Cdc25C
CDK2-associated dual specificity phosphatase
-
-
-
-
Ch-1PTPase
CPTP1
-
-
-
-
CQMa102 phosphatase
Cryp-2
cysteine-dependent protein tyrosine phosphatase
DEP-1
DLAR
-
-
-
-
dPTP61F
-
dPTP61F plays a central role in counteracting PTK-mediated signaling pathways as well as in regulating actin reorganization and remodeling through tyrosine dephosphorylation of critical substrates in Drosophila
dual specificity phosphatase
Dual specificity phosphatase Cdc25A
-
-
-
-
Dual specificity phosphatase Cdc25B
-
-
-
-
Dual specificity phosphatase Cdc25C
-
-
-
-
Dual specificity protein phosphatase hVH1
-
-
-
-
Dual specificity protein phosphatase hVH2
-
-
-
-
Dual specificity protein phosphatase hVH3
-
-
-
-
Dual specificity protein phosphatase PYST1
-
-
-
-
Dual specificity protein phosphatase PYST2
-
-
-
-
Dual specificity protein phosphatase VHR
-
-
-
-
dual-specificity phosphatase
Dual-specificity tyrosine phosphatase TS-DSP6
-
-
-
-
Dual-specificity tyrosine phosphatase YVH1
-
-
-
-
DUSP
EhPRL
ES cell phosphatase
-
-
-
-
HCP
-
-
-
-
HD-PTP
Hematopoietic cell protein-tyrosine phosphatase
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
-
-
-
-
Hematopoietic protein-tyrosine phosphatase
-
-
-
-
HEPTP
His domain protein tyrosine phosphatase
HPTP beta-like tyrosine phosphatase
-
-
-
-
HPTP eta
-
-
-
-
hPTPE1
-
-
-
-
ICAAR
-
-
-
-
Islet cell autoantigen related protein
-
-
-
-
kinase associated phosphatase
-
-
-
-
L-CA
-
-
-
-
LAR
Late protein H1
-
-
-
-
LCA
-
-
-
-
LCA-related phosphatase
-
-
-
-
leucocyte common antigen-related protein tyrosine phosphatase
Leukocyte antigen related
-
-
-
-
LMJF_16_0230
LmPRL-1
LMW PTPase
LMW-PTP
LMWPTP
Low molecular weight cytosolic acid phosphatase
-
-
-
-
Low molecular weight phosphotyrosine protein phosphatase
low molecular weight protein tyrosine phosphatase
low-molecular weight PTPase
low-molecular-weight protein tyrosine phosphatase
LRP
-
-
-
-
Lymphoid phosphatase
-
-
-
-
LyP
M1851
-
-
-
-
MAP-kinase phosphatase CPG21
-
-
-
-
MEG
-
-
-
-
mitogen-activated protein kinase-specific tyrosine phosphatase
-
Mitosis initiation protein
-
-
-
-
Mitosis initiation protein MIH1
-
-
-
-
Mitotic inducer homolog
-
-
-
-
MKP-1 like protein tyrosine phosphatase
-
-
-
-
MKP-3
MKP-4
MKP-5
MPTP
-
-
-
-
MPTP-PEST
-
-
-
-
MPtpA
NC-PTPCOM1
Neural-specific protein-tyrosine phosphatase
-
-
-
-
non-receptor protein tyrosine phosphatase
ORF5
-
-
-
-
orphan protein tyrosine phosphatase
OST-PTP
P19-PTP
-
-
-
-
P80
-
-
-
-
PC12-PTP1
-
-
-
-
PCPTP1
Phogrin
-
-
-
-
Phosphacan
-
-
-
-
phosphatase, phosphoprotein (phosphotyrosine)
-
-
-
-
phosphatase, phosphotyrosine
-
-
-
-
phosphoprotein phosphatase (phosphotyrosine)
-
-
-
-
phosphotyrosine histone phosphatase
-
-
-
-
phosphotyrosine phosphatase
-
-
-
-
Phosphotyrosine phosphatase 13
-
-
-
-
phosphotyrosine protein phosphatase
-
-
-
-
phosphotyrosylprotein phosphatase
-
-
-
-
Pmp1p
PPM
-
the recombinant protein exhibits protein-tyrosine phosphatase in addition to its predicted protein-serine/threonine phosphatase activity
PRL
PRL-1
probable low molecular weight protein-tyrosine-phosphatase
protein phosphotyrosine phosphatase
-
-
-
-
protein tyrosine phosphatase
protein tyrosine phosphatase 1B
protein tyrosine phosphatase epsilon
protein tyrosine phosphatase-1B
Protein tyrosine phosphatase-NP
-
-
-
-
Protein-protein-tyrosine phosphatase HA2
-
-
-
-
protein-tyrosine phosphatase
Protein-tyrosine phosphatase 1B
Protein-tyrosine phosphatase 1C
-
-
-
-
Protein-tyrosine phosphatase 1E
-
-
-
-
Protein-tyrosine phosphatase 2C
-
-
-
-
Protein-tyrosine phosphatase 2E
-
-
-
-
Protein-tyrosine phosphatase 3CH134
-
-
-
-
Protein-tyrosine phosphatase CL100
-
-
-
-
Protein-tyrosine phosphatase D1
Protein-tyrosine phosphatase ERP
-
-
-
-
Protein-tyrosine phosphatase G1
-
-
-
-
Protein-tyrosine phosphatase H1
-
-
-
-
Protein-tyrosine phosphatase LC-PTP
-
-
-
-
Protein-tyrosine phosphatase MEG1
-
-
-
-
Protein-tyrosine phosphatase MEG2
-
-
-
-
Protein-tyrosine phosphatase P19
-
-
-
-
Protein-tyrosine phosphatase PCPTP1
-
-
-
-
Protein-tyrosine phosphatase pez
-
-
-
-
Protein-tyrosine phosphatase PTP-RL10
-
-
-
-
Protein-tyrosine phosphatase PTP36
-
-
-
-
Protein-tyrosine phosphatase PTPL1
-
-
-
-
Protein-tyrosine phosphatase striatum-enriched
-
-
-
-
Protein-tyrosine phosphatase SYP
-
-
-
-
Protein-tyrosine-phosphatase SL
-
-
-
-
Protein-tyrosine-phosphate phosphohydrolase
-
-
-
-
PTEN
PTK
PTP
PTP IA-2beta
-
-
-
-
PTP-1B
PTP-1C
-
-
-
-
PTP-1D
-
-
-
-
PTP-2C
-
-
-
-
PTP-BAS
PTP-E1
-
-
-
-
PTP-H1
-
-
-
-
PTP-HA2
-
-
-
-
PTP-like phytase
PTP-MEG2
PTP-NP
-
-
-
-
PTP-oc
PTP-PEST
PTP-SH2beta
-
-
-
-
PTP1
PTP1B
PTP1C
-
-
-
-
PTP1D
-
-
-
-
PTP2C
-
-
-
-
PTP36
PtpA
PTPalpha
PTPase
PTPase YVH1
-
-
-
-
PTPase-MEG1
PTPase-MEG2
PtpB
PTPB1
PTPBR7
PTPD1
PTPepsilon
PTPG1
-
-
-
-
PTPH1
PTPLP
PTPN1
PTPN11
PTPN12
PTPN14
PTPN22
PTPN23
PTPN3
PTPN4
PTPN5
PTPN6
PTPN7
PTPN9
PTPNE6
-
-
-
-
PTPRJ
PTPRO
PTPRQ
PTPRR
PTPRT
PY protein phosphatase
-
-
-
-
Pyp1p
Pyp2p
R-PTP-alpha
-
-
-
-
R-PTP-beta
-
-
-
-
R-PTP-delta
-
-
-
-
R-PTP-epsilon
-
-
-
-
R-PTP-eta
-
-
-
-
R-PTP-gamma
-
-
-
-
R-PTP-kappa
-
-
-
-
R-PTP-mu
-
-
-
-
R-PTP-zeta
-
-
-
-
R2B phosphatase
receptor protein tyrosine phosphatase rho
Receptor-linked protein-tyrosine phosphatase 10D
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 99A
-
-
-
-
RNA/RNP complex-intereracting phosphatase
-
-
-
-
ROL B protein
-
-
-
-
RPTPalpha
RPTPepsilon
RPTPkappa
RPTPrho/PTPRT
Saci-PTP
Saci0545
SH-PTP1
-
-
-
-
SH-PTP2
-
-
-
-
SH-PTP3
-
-
-
-
SHP
-
-
-
-
SHP-1
SHP-2
SHP1
SHP2
Siw14
Small tyrosine phosphatase
-
-
-
-
Small, acidic phosphotyrosine protein phosphatase
-
-
-
-
Spd1837
SPD_1837
SPy_0036
STEP
STEP33
-
STEP is processed into a 33 kDa isoform by calpain-mediated cleavage, STEP33 retains catalytic activity but is unable to bind to phosphorylated ERK
Stp1
striatal-enriched PTP
String protein
-
-
-
-
Syp
-
-
-
-
T-cell protein tyrosine phosphatase
T-cell protein-tyrosine phosphatase
-
-
-
-
T-DSP11
-
-
-
-
T200
-
-
-
-
TCPTP
TcPTP1
Testis-and skeletal-muscle-specific DSP
-
-
-
-
TpbA
tyrosine O-phosphate phosphatase
-
-
-
-
tyrosine phosphatase
Tyrosine phosphatase CBPTP
-
-
-
-
tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1
tyrosine-protein phosphatase non-receptor type 22
tyrosylprotein phosphatase
-
-
-
-
VHR
YopH
[phosphotyrosine]protein phosphatase
-
-
-
-
additional information
CD45
-
-
-
-
Ch-1PTPase
-
-
-
-
HEPTP
-
-
-
-
Low molecular weight phosphotyrosine protein phosphatase
UniProt
Low molecular weight phosphotyrosine protein phosphatase
UniProt
-
low molecular weight protein tyrosine phosphatase
Streptococcus pneumoniae serotype 2
-
low molecular weight protein tyrosine phosphatase
Streptococcus pneumoniae serotype 2 D39
-
-
low molecular weight protein tyrosine phosphatase
Streptococcus pneumoniae serotype 2 NCTC 7466
-
-
low molecular weight protein tyrosine phosphatase
-
low-molecular-weight protein tyrosine phosphatase
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
-
LyP
-
-
-
-
NC-PTPCOM1
-
-
-
-
OST-PTP
-
-
-
-
probable low molecular weight protein-tyrosine-phosphatase
UniProt
probable low molecular weight protein-tyrosine-phosphatase
UniProt
-
probable low molecular weight protein-tyrosine-phosphatase
UniProt
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase 1B
-
-
protein tyrosine phosphatase 1B
-
Protein-tyrosine phosphatase 1B
-
-
-
-
Protein-tyrosine phosphatase D1
-
-
-
-
PTP
-
-
PTP-1B
-
-
-
-
PTP-BAS
-
-
-
-
PTP-oc
-
the protein is produced from the distal promotor, PTP-oc is identical to PTPRO, except that its extracellular domain is extremely short with eight amino acids in all
PTP1B
-
-
PTP1B
-
PTPase-MEG1
-
-
-
-
PTPase-MEG2
-
-
-
-
PTPD1
-
PTPD1 is a cytosolic nonreceptor tyrosine phosphatase and a positive regulator of the Src-epidermal growth factor transduction pathway
PTPN6
-
-
-
-
PTPRO
-
a receptor-type PTP, the protein is produced from the distal promotor
RPTPalpha
-
-
-
-
Saci0545
locus name, dual specific phosphatase EC 3.1.3.16/EC 3.1.3.48
Saci0545
locus name, dual specific phosphatase EC 3.1.3.16/EC 3.1.3.48
-
SHP2
-
Shp2 is a nonreceptor PTP that plays a positive role in cell signaling by growth factors and cytokines and is involved in regulation of cell proliferation, differentiation, and migration
STEP
-
-
-
-
TCPTP
-
-
-
-
tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1
-
-
-
additional information
-
CRYP-2 is identical in sequence to the human glomerular epithelial protein-1
additional information
-
SHP-1 belongs to the family of non-receptor protein tyrosine phosphatases
additional information
ED-Eya2 belongs to the haloacid dehalogenase family
additional information
-
SHP-1 is a member of SH2 domain-containing PTP subfamily
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
-
-
-
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, transition state of reaction, kinetic isotope effects, overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, role of residue 182
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
thermodynamic parameters
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, kinetic isotope effects
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
comparison of kinetic properties of different transmembrane and cytosolic isozymes
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
overview on mechanism and transition state
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
overview on mechanism and transition state
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
overview on mechanism and transition state
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism, features required for substrate
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
activation mechanism
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
in addition to active site, enzyme has a low-affinity noncatalytic aryl phosphate-binding site
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
H148 acts as a general acid catalyst, D115 assists the protonation of the leaving group of a substrate, and D76 and D112 are involved in binding of magnesium ions
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
conformation of active site is favorable for phosphotyrosine binding. Interaction of D115 and R13 to stabilize the conformation of the active cavity. A41 and G45 form a noncharged surface around the active cavity, which is surrounded by a flexible wall made of the loop region from F40 to T48
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
arrangement of two metal ions, a phosphate ion, and amino acid residues in the catalytic site is identical to that of PS/Tpases
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
motif H74C(X)5R81 is involved in catalysis
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
ping-pong mechanism, catalysis proceeds through a two-step mechanism involving a phosphocysteine intermediate. In the first step, a nucleophilic cysteine thiolate attacks the phosphate ester moiety of the substrate, resulting in formation of a phosphoenzyme intermediate with release of the peptidyl tyrosine. The second step occurs via attack of water on the phosphoenzyme intermediate, and yields the final products inorganic phosphate and the regenerated enzyme. The central binding site for the substrate is the P-loop, a region at the bottom of a pocket that includes the nucleophilic cysteine and backbone amide groups oriented in a horseshoe fashion, catalytic cycle, detailed overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism of the dephosphorylation catalysed by MptpA
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
the phosphatase domain of PTPRs catalyze a two-step phosphate monoester hydrolysis reaction through a highly conserved sequence motif (H/V)CX5R(S/T) with a nucleophilic cysteine; the phosphatase domain of PTPRs catalyze a two-step phosphate monoester hydrolysis reaction through a highly conserved sequence motif (H/V)CX5R(S/T) with a nucleophilic cysteine
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview; for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview; for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
mechanism
-
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
protein-tyrosine-phosphate phosphohydrolase
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
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CAS REGISTRY NUMBER
COMMENTARY
79747-53-8
-
97162-86-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-O-methylfluorescein phosphate + H2O
3-O-methylfluorescein + phosphate
-
-
-
-
?
4-methylumbelliferyl phosphate + H2O
4-methylumbelliferone + phosphate
-
-
-
-
?
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferol + phosphate
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferone + phosphate
Ac-DGEEpYDDPF-NH2 + H2O
Ac-DGEEYDDPF-NH2 + phosphate
-
SKAP-HOM Tyr75 peptide
-
-
?
Ac-YGEEpYDDLY-NH2 + H2O
Ac-YGEEYDDLY-NH2 + phosphate
-
consensus peptide 1
-
-
?
Ac-YGYEpYDDEY-NH2 + H2O
Ac-YGYEYDDEY-NH2 + phosphate
-
consensus peptide 2
-
-
?
bis-(p-phosphophenyl) methane + H2O
?
synthetic high-affinity low-molecular weight nonpeptide substrate
-
-
?
carrier protein-Cdc2-phosphotyrosine + H2O
carrier protein-Cdc2-tyrosine + phosphate
-
-
-
-
?
carrier protein-Y3-phosphotyrosine + H2O
carrier protein-Y3-tyrosine + phosphate
-
-
-
-
?
carrier protein-Y5-phosphotyrosine + H2O
carrier protein-Y5-tyrosine + phosphate
-
-
-
-
?
Cdk2-pTpY + H2O
Cdk2-TpY + phosphate
-
dephosphorylates Cdk/cyclins on pThr14 and/or pTyr15 residues
-
-
?
difluoromethylumbelliferyl phosphate + H2O
difluoromethylumbelliferone + phosphate
-
-
-
?
epidermal growth factor receptor + H2O
? + phosphate
-
with phosphotyrosine Tyr992
-
-
?
FDNL(pY)2WDQD + H2O
FDNLYYWDQD + 2 phosphate
-
dephosphorylation at Tyr1221/1222
-
-
?
FMN + H2O
? + phosphate
-
71.8% of the activity with 4-nitrophenyl phosphate, lung enzyme
-
-
?
GESDGGpYMDMSKD + H2O
GESDGGYMDMSKD + phosphate
-
this peptide corresponds to the sequence containing Tyr740 of the human platelet-derived growth factor receptor
-
-
?
hirudin + H2O
? + phosphate
-
hirudin from leech, phosporylated on tyrosine
-
-
?
KRLIEDNE(pY)TARGQ + H2O
KRLIEDNEYTARGQ + phosphate
-
phosphopeptide derived from autophosphorylation of mammalian tyrosine kinase Lck
-
-
?
lysozyme + H2O
? + phosphate
-
reduced, carboxymethylated and maleylated
-
-
?
nicotinic acetylcholine receptor + H2O
? + phosphate
-
i.e. nAChR
-
-
?
phosphorylated Abelson interacting protein + H2O
Abelson interacting protein + phosphate
-
-
-
-
?
phosphorylated Abl tyrosine kinase + H2O
Abl tyrosine kinase + phosphate
-
-
-
-
?
phosphorylated adenomatous Polyposis coli-protein + H2O
adenomatous Polyposis coli-protein + phosphate
-
-
-
-
?
phosphorylated AMP-activated protein kinase + H2O
AMP-activated protein kinase + phosphate
phosphorylated c-Kit + H2O
c-Kit + phosphate
-
dephosphorylation occurs at tyrosines 567/569 and 719
-
-
?
phosphorylated Cdk2-pTpY/CycA protein + H2O
Cdk2-pTpY/CycA protein + phosphate
-
-
-
?
phosphorylated colony-stimulating factor 1 receptor + H2O
colony-stimulating factor 1 + phosphate
-
-
-
-
?
phosphorylated Down syndrome cell adhesion molecule + H2O
Down syndrome cell adhesion molecule + phosphate
-
-
-
-
?
phosphorylated epidermal growth factor receptor + H2O
epidermal growth factor receptor + phosphate
phosphorylated ERK2 + H2O
ERK2 + phosphate
HePTP binds the phosphorylated tyrosine of the Erk2 peptide (pY185), Erk2 residue T183, which is phosphorylated in maximally activated Erk2, is not essential for substrate recognition and binding by HePTP
-
-
?
phosphorylated eukaryotic-initiation-factor-4G + H2O
eukaryotic-initiation-factor-4G + phosphate
-
-
-
-
?
phosphorylated extracellular signal regulated kinase + H2O
extracellular signal regulated kinase + phosphate
-
-
-
-
?
phosphorylated extracellular signal-regulated kinase 1 + H2O
extracellular signal-regulated kinase 1 + phosphate
phosphorylated extracellular signal-regulated kinase 2 + H2O
extracellular signal-regulated kinase 2 + phosphate
phosphorylated focal adhesion kinase + H2O
focal adhesion kinase + phosphate
-
dephosphorylation occurs at Tyr-397, PTPD1 activity is required for focal adhesion kinase autophosphorylation and adhesion plaque stability
-
-
?
phosphorylated fragile X related + H2O
fragile X related + phosphate
-
-
-
-
?
phosphorylated Gln3 + H2O
Gln3 + phosphate
-
Siw14, in combination with the protein kinase Npr1, regulates the intracellular localization of Gln3
-
-
?
phosphorylated hepatocyte growth factor regulated tyrosine kinase substrate + H2O
hepatocyte growth factor regulated tyrosine kinase substrate + phosphate
-
-
-
-
?
phosphorylated IGF-I receptor + H2O
IGF-I receptor + phosphate
-
isozyme p52shc
-
-
?
phosphorylated IGF-II mRNA-binding protein + H2O
IGF-II mRNA-binding protein + phosphate
-
-
-
-
?
phosphorylated insulin receptor substrate-1 + H2O
insulin receptor substrate-1 + phosphate
-
-
-
-
?
phosphorylated insulin receptor substrate-2 + H2O
insulin receptor substrate-2 + phosphate
-
-
-
-
?
phosphorylated JAK2 + H2O
JAK2 + phosphate
-
SHP2 dephosphorylates the Tyr1007 site, preventing the formation of the JAK2-Socs1 complex
-
-
?
phosphorylated Jun amino-terminal kinase + H2O
Jun amino-terminal kinase + phosphate
-
-
-
-
?
phosphorylated Lck + H2O
Lck + phosphate
-
component of the T cell receptor signaling pathway
-
-
?
phosphorylated mitogen-activated protein kinase + H2O
mitogen-activated protein kinase + phosphate
-
-
-
-
?
phosphorylated mitogen-activated protein kinase Pmk1p + H2O
mitogen-activated protein kinase Pmk1p + phosphate
phosphorylated Munc18c + H2O
Munc18c + phosphate
-
dephosporylation at Tyr218/219 and Tyr521
-
-
?
phosphorylated p130 Crk-associated substrate + H2O
p130 Crk-associated substrate + phosphate
-
-
-
-
?
phosphorylated p190B Rho-GTPase-activating protein + H2O
p190B Rho-GTPase-activating protein + phosphate
-
-
-
-
?
phosphorylated p38 mitogen-activated protein kinase + H2O
p38 mitogen-activated protein kinase + phosphate
phosphorylated PDGF- and VEGF-receptor related + H2O
PDGF- and VEGF-receptor related + phosphate
-
-
-
-
?
phosphorylated platelet-derived growth factor receptor + H2O
platelet-derived growth factor receptor + phosphate
-
-
-
-
?
phosphorylated poly(A)-binding protein + H2O
poly(A)-binding protein + phosphate
-
-
-
-
?
phosphorylated proline serine threonine-rich phosphatase interacting protein + H2O
proline serine threonine-rich phosphatase interacting protein + phosphate
-
-
-
-
?
phosphorylated proline-rich tyrosine kinase 2 + H2O
proline-rich tyrosine kinase 2 + phosphate
-
the enzyme directly binds to and dephosphorylates proline-rich tyrosine kinase 2 at Tyr402
-
-
?
phosphorylated protein kinase-like endoplasmic reticulum kinase + H2O
protein kinase-like endoplasmic reticulum kinase + phosphate
-
dephosphorylation at Tyr615
-
-
?
phosphorylated pyruvate kinase M2 + H2O
pyruvate kinase M2 + phosphate
-
-
-
-
?
phosphorylated RET(C634R) oncoprotein + H2O
RET(C634R) oncoprotein + phosphate
-
dephosphorylation at Tyr905 and Tyr1062
-
-
?
phosphorylated RET-MEN2A oncoprotein + H2O
RET-MEN2A oncoprotein + phosphate
-
dephosphorylation at Tyr905 and Tyr1062
-
-
?
phosphorylated RET/PTC1 oncoprotein + H2O
RET/PTC1 oncoprotein + phosphate
-
dephosphorylation at Tyr905 and Tyr1062
-
-
?
phosphorylated signal transducer and activator of transcription 3 + H2O
signal transducer and activator of transcription 3 + phosphate
-
-
-
-
?
phosphorylated specifically Rac1-associated protein 1 + H2O
specifically Rac1-associated protein 1 + phosphate
-
-
-
-
?
phosphorylated Src tyrosine kinase + H2O
Src tyrosine kinase + phosphate
-
PTPD1 associates with and activates Src tyrosine kinase
-
-
?
phosphorylated STAT5 + H2O
STAT5 + phosphate
-
purified SHP2 protein directly dephosphorylates STAT5 or tyrosine-phosphorylated peptides derived from STAT5
-
-
?
phosphorylated T cell antigen receptor chain zeta + H2O
T cell antigen receptor chain zeta + phosphate
-
-
-
-
?
phosphorylated T cell antigen receptor zeta + H2O
T cell antigen receptor zeta + phosphate
-
-
-
-
?
phosphorylated T-cell receptor-zeta subunit + H2O
T-cell receptor-zeta subunit + phosphate
-
dephosphorylates ITAMs of the T-cell receptor-zeta subunit
-
-
?
phosphorylated TCRzeta + H2O
TCRzeta + phosphate
-
PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway
-
-
?
phosphorylated valosin containing protein + H2O
valosin containing protein + phosphate
-
-
-
-
?
phosphorylated vascular endothelial growth factor receptor 2 + H2O
vascular endothelial growth factor receptor 2 + phosphate
phosphorylated Vav + H2O
Vav + phosphate
-
component of the T cell receptor signaling pathway
-
-
?
phosphorylated voltage-gated potassium channel subunit Kv2.1 + H2O
voltage-gated potassium channel subunit Kv2.1 + phosphate
-
-
-
-
?
phosphorylated YwqD
YwqD + phosphate
-
protein implicated in UDP-glucuronate synthesis
-
-
?
phosphorylated YwqF
YwqF + phosphate
-
protein implicated in UDP-glucuronate synthesis
-
-
?
phosphotyrosyl myelin basic protein + H2O
tyrosyl-myelin basic protein + phosphate
-
-
-
-
?
phosphotyrosyl reduced carboxyamidomethylated and maleylated lysozyme + H2O
tyrosyl-reduced carboxyamidomethylated and maleylated lysozyme + phosphate
-
-
-
-
?
SKAP-HOM + H2O
?
-
a cytosolic adaptor protein required for proper activation of the immune system, a bona fide Lyp substrate
-
-
?
soluble N-ethylmaleimide-sensitive factor attachment protein receptor + H2O
soluble N-ethylmaleimide-sensitive factor attachment protein receptor + phosphate
-
-
-
-
?
TGFLTELpYVATRWY + H2O
TGFLTELYVATRWY + phosphate
-
this peptide corresponds to the sequence containing Tyr204 of the human extracellular signal-regulated kinase
-
-
?
tyrosine-phosphorylated myelin basic protein + H2O
myelin basic protein + phosphate
-
-
-
?
YCRPESQEHPEADPGAAPpYLK + H2O
YCRPESQEHPEADPGAAYLK + phosphate
-
YCRPESQEHPEADPGAApYLK is signal transducer and activator of transcription 3, is dephosphorylated at Y705
-
-
?
[casein]-tyrosine phosphate + H2O
[casein]-tyrosine + phosphate
-
-
-
?
[cytosolic 6-phosphofructokinase]-tyrosine phosphate + H2O
[cytosolic 6-phosphofructokinase]-tyrosine + phosphate
[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
[EGF receptor]-tyrosine1018 phosphate + H2O
[EGF receptor]-tyrosine1018 + phosphate
highest activity
-
-
?
[epidermal growth factor receptor 2]-tyrosine phosphate + H2O
[epidermal growth factor receptor 2]-tyrosine + phosphate
-
dephosphorylation of epidermal growth factor receptor 2 (HER2)-pY1196 site
-
-
?
[epidermal growth factor receptor]-tyrosine phosphate + H2O
[epidermal growth factor receptor]-tyrosine + phosphate
[Eps15 peptide846-854 P850V]-tyrosine phosphate + H2O
[Eps15 peptide846-854 P850V]-tyrosine + phosphate
-
-
-
-
?
[Eps15 peptide846-854]-tyrosine phosphate + H2O
[Eps15 peptide846-854]-tyrosine + phosphate
[FAK]-tyrosine phosphate + H2O
[FAK]-tyrosine + phosphate
-
dephosphorylation at Tyr397
-
-
?
[FYN kinase]-tyrosine phosphate + H2O
[FYN kinase]-tyrosine + phosphate
-
-
-
-
?
[HER2]-tyrosine phosphate + H2O
[HER2]-tyrosine + phosphate
-
dephosphorylation at Tyr1112, Tyr1196, Tyr1221, Tyr1222, and Tyr1248
-
-
?
[insulin receptor kinase]-tyrosine phosphate + H2O
[insulin receptor kinase]-tyrosine + phosphate
-
-
-
-
?
[myelin basic protein]-tyrosine phosphate + H2O
[myelin basic protein]-tyrosine + phosphate
-
-
-
?
[p130Cas]-tyrosine phosphate + H2O
[p130Cas]-tyrosine + phosphate
-
dephosphorylation at Tyr165
-
-
?
[p190RhoGAP]-tyrosine phosphate + H2O
[p190RhoGAP]-tyrosine + phosphate
-
dephosphorylation at Tyr1105
-
-
?
[paxillin]-tyrosine phosphate + H2O
[paxillin]-tyrosine + phosphate
-
dephosphorylation at Tyr118
-
-
?
[SRC]-tyrosine phosphate + H2O
[SRC]-tyrosine + phosphate
-
dephosphorylation at Tyr416
-
-
?
[sulfide quinone oxidoreductase]-tyrosine phosphate + H2O
[sulfide quinone oxidoreductase]-tyrosine + phosphate
[trifunctional enzyme]-tyrosine phosphate + H2O
[trifunctional enzyme]-tyrosine + phosphate
[VAV2]-tyrosine phosphate + H2O
[VAV2]-tyrosine + phosphate
-
dephosphorylation at Tyr172
-
-
?
1-naphthyl phosphate + H2O
1-naphthol + phosphate
-
89.3% of the activity with 4-nitrophenyl phosphate, lung enzyme
-
-
?
3-o-methyl fluorescein phosphate + H2O
3-o-methyl fluorescein + phosphate
-
-
-
?
3-o-methyl fluorescein phosphate + H2O
3-o-methyl fluorescein + phosphate
-
-
-
?
3-o-methyl fluorescein phosphate + H2O
3-o-methyl fluorescein + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
708122, 708290, 709102, 709293, 710237, 729298, 729368, 729393, 730564, 730970, 729379, 749934, 750022, 750047, 750305, 751130, 752277, 749850, 750056, 749811, 750513, 752091
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
acid phosphatase activity, best tested substrate
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
Streptococcus pneumoniae serotype 2
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
Streptococcus pneumoniae serotype 2 D39
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
Streptococcus pneumoniae serotype 2 NCTC 7466
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?