Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.1.3.17 - [phosphorylase] phosphatase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.
Adenoma
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
Adenomatous Polyposis Coli
Expression analysis of pediatric solid tumor cell lines using oligonucleotide microarrays.
African Swine Fever
Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2? and inhibiting activation of pro-apoptotic CHOP.
The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection.
The MyD116 African swine fever virus homologue interacts with the catalytic subunit of protein phosphatase 1 and activates its phosphatase activity.
Alzheimer Disease
CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease.
Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease.
Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease.
Dephosphorylation of tau protein from Alzheimer's disease patients.
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation.
Amyotrophic Lateral Sclerosis
Prevention of mitochondrial impairment by inhibition of protein phosphatase 1 activity in amyotrophic lateral sclerosis.
Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model.
Arrhythmias, Cardiac
WWP2 and PPP1R3A are abnormally regulated in arrhythmia-induced cardiac damage.
Astrocytoma
R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals.
Ataxia Telangiectasia
Overexpression of CDCA2 in Human Squamous Cell Carcinoma: Correlation with Prevention of G1 Phase Arrest and Apoptosis.
Atrial Fibrillation
Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.
Erratum to: Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.
Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.
Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.
Bone Resorption
Protein phosphatase 1 regulatory subunit 18 suppresses the transcriptional activity of NFATc1 via regulation of c-fos.
Protein phosphatase inhibitors and bone resorption: inhibition by okadaic acid and biphasic actions of calyculin-A.
Brain Ischemia
Regulatory proteins of eukaryotic initiation factor 2-alpha subunit (eIF2alpha) phosphatase, under ischemic reperfusion and tolerance.
Breast Neoplasms
Detection of breast tumor progesterone receptor isoforms with the PR-enzyme immunoassay kit (Abbott). Effect of heat shock proteins on epitope recognition.
Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway.
Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway.
Protein phosphatase 1, regulatory subunit 15B is a survival factor for ER?-positive breast cancer.
Carcinogenesis
Production of chemokine CXCL1/KC by okadaic acid through the nuclear factor-kappaB pathway.
Protein phosphatase 1 and its complexes in carcinogenesis.
Protein phosphatase 1 in tumorigenesis: Is it worth a closer look?
Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis.
Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway.
Protein Phosphatase PP1 Negatively Regulates IRF3 in Response to GCRV Infection in Grass Carp (Ctenopharyngodon idella).
Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage.
Carcinoma
Characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human adrenal cortex.
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Correction: Liu, Y.-S.; et al. Inhibition of Protein Phosphatase 1 Stimulates Noncanonical ER Stress eIF2? Activation to Enhance Fisetin-Induced Chemosensitivity in HDAC Inhibitor-Resistant Hepatocellular Carcinoma Cells. Cancers 2019, 11, 918.
IPP5, a novel inhibitor of protein phosphatase 1, suppresses tumor growth and progression of cervical carcinoma cells by inducing G2/M arrest.
Sensitization of cervical carcinoma cells to paclitaxel by an IPP5 active mutant.
Carcinoma, Hepatocellular
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Correction: Liu, Y.-S.; et al. Inhibition of Protein Phosphatase 1 Stimulates Noncanonical ER Stress eIF2? Activation to Enhance Fisetin-Induced Chemosensitivity in HDAC Inhibitor-Resistant Hepatocellular Carcinoma Cells. Cancers 2019, 11, 918.
Evaluation of cyanobacterial toxicity using different biotests and protein phosphatase inhibition assay.
Hypoxia-induced NIPP1 activation enhances metastatic potential and predicts poor prognosis in hepatocellular carcinoma.
Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas.
Inhibition of protein phosphatase 1 stimulates noncanonical ER stress eIF2? activation to enhance fisetin-induced chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells.
Long term regulation of glycogen metabolizing enzymes by insulin in H4 hepatoma cells.
Molecular cloning and sequence analysis of cDNA for the catalytic subunit 1 alpha of rat kidney type 1 protein phosphatase, and detection of the gene expression at high levels in hepatoma cells and regenerating livers as compared to rat livers.
Up-regulation of nuclear PP1alpha and PP1delta in hepatoma cells.
Carcinoma, Non-Small-Cell Lung
Inflammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells.
Cardiomegaly
17?-Estradiol and/or estrogen receptor alpha signaling blocks protein phosphatase 1 mediated ISO induced cardiac hypertrophy.
E2/ER ? Enhances Calcineurin Protein Degradation and PI3K/Akt/MDM2 Signal Transduction to Inhibit ISO-Induced Myocardial Cell Apoptosis.
Cardiomyopathies
Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts.
Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.
More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease.
Cardiovascular Diseases
Effects of PP1-12, a novel protein phosphatase-1 inhibitor, on ventricular function and remodeling after myocardial infarction in rats.
Cell Transformation, Neoplastic
CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.
Cholera
A novel assay for evaluating glycogenolysis in rat adipocytes and the inability of insulin to antagonize glycogenolysis in this cell type.
Classical Swine Fever
Interaction of Structural Glycoprotein E2 of Classical Swine Fever Virus with Protein Phosphatase 1 Catalytic Subunit Beta (PPP1CB).
Colitis
Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice.
Colonic Neoplasms
Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells.
Colorectal Neoplasms
Genetic alterations and expression of the protein phosphatase 1 genes in human cancers.
PPP1R3 gene (protein phosphatase 1) alterations in colorectal cancer and its relationship to metastasis.
The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer.
Coronary Artery Disease
Association between the PPP1R3B polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke in a southern Chinese Han population.
Cystitis
Effects of herpes simplex virus vectors encoding poreless TRPV1 or protein phosphatase 1? in a rat cystitis model induced by hydrogen peroxide.
Diabetes Mellitus, Experimental
Purification and the immunological characterization of rat protein phosphatase 2A: enzyme levels in diabetic liver and heart.
Diabetes Mellitus, Type 1
Hepatic glycogen synthase phosphatase and phosphorylase phosphatase activities are increased in obese (fa/fa) hyperinsulinemic Zucker rats: effects of glyburide administration.
Diabetes Mellitus, Type 2
Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.
Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome.
Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.
Molecular recognition of the protein phosphatase 1 glycogen targeting subunit by glycogen phosphorylase.
Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content.
Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM.
The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population.
The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus.
[Study on association of PPP1R3 gene 5 bp deletion/insertion within 3'-untranslated region polymorphism with type 2 diabetes]
[Study on the association of PPP1R3 gene polymorphism with type 2 diabetes in Han population of Anhui province]
Diabetic Nephropathies
[Down-regulation of PHLPP1 expression ameliorates high glucose-induced autophagy inhibition and apoptosis promotion of podocytes by activating PI3K/AKT/mTOR pathway].
Disorders of Sex Development
Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations.
Encephalomyelitis
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Encephalomyelitis, Autoimmune, Experimental
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Escherichia coli Infections
PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.
Esophageal Squamous Cell Carcinoma
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Frontotemporal Lobar Degeneration
SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation.
Gastroenteritis
Alphacoronavirus protein 7 modulates host innate immune response.
Glioblastoma
MicroRNA-182 targets protein phosphatase 1 regulatory inhibitor subunit 1C in glioblastoma.
Mislocalization of the E3 ligase, beta-transducin repeat containing protein 1 ({beta}-TrCP1) in glioblastoma uncouples negative feedback between the PH domain Leucine-rich repeat Protein Phosphatase 1 (PHLPP1) and Akt.
Nuclear Protein Phosphatase 1 ? (PP1A) Expression is Associated with Poor Prognosis in p53 Expressing Glioblastomas.
Glucose Intolerance
Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background.
Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1.
Glycosuria
Increase in liver protein phosphatase-1 in spontaneously diabetic Chinese hamsters.
Heart Defects, Congenital
De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease.
Heart Diseases
PP1? functionally augments the alternative splicing of CaMKII? through interaction with ASF.
Heart Failure
AAV-mediated gene therapy for heart failure: enhancing contractility and calcium handling.
AAV9.I-1c Delivered via Direct Coronary Infusion in a Porcine Model of Heart Failure Improves Contractility and Mitigates Adverse Remodeling.
Activation of endogenous protein phosphatase 1 enhances the calcium sensitivity of the ryanodine receptor type 2 in murine ventricular cardiomyocytes.
Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure.
Astragalosides increase the cardiac diastolic function and regulate the "Calcium sensing receptor-protein kinase C-protein phosphatase 1" pathway in rats with heart failure.
Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1.
Erratum to: Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.
Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.
Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.
Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca2+ cycling.
Phospholamban: a key determinant of cardiac function and dysfunction.
Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure.
Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.
Targeting protein phosphatase 1 in heart failure.
Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility.
[Effects of valsartan on sarcoplasmic reticulum calcium adenodine triphosphatase, protein kinase A and protein phosphatase 1 alpha in a rabbit model of heart failure]
Herpes Simplex
A conserved domain of herpes simplex virus ICP34.5 regulates protein phosphatase complex in mammalian cells.
Amino acid substitutions in the effector domain of the gamma(1)34.5 protein of herpes simplex virus 1 have differential effects on viral response to interferon-alpha.
An N-terminal arginine-rich cluster and a proline-alanine-threonine repeat region determine the cellular localization of the herpes simplex virus type 1 ICP34.5 protein and its ligand, protein phosphatase 1.
Dephosphorylation of eIF2{alpha} Mediated by the {gamma}134.5 Protein of Herpes Simplex Virus 1 Facilitates Viral Neuroinvasion.
Effects of herpes simplex virus vectors encoding poreless TRPV1 or protein phosphatase 1? in a rat cystitis model induced by hydrogen peroxide.
ICP34.5 protein of herpes simplex virus facilitates the initiation of protein translation by bridging eukaryotic initiation factor 2alpha (eIF2alpha) and protein phosphatase 1.
The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells.
Herpes Zoster
Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis.
Holoprosencephaly
Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations.
Huntington Disease
Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease.
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.
Hyperglycemia
DUSP1 recuses diabetic nephropathy via repressing JNK-Mff-mitochondrial fission pathways.
Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression.
Hyperglycemia acutely increases monocyte extracellular signal-regulated kinase activity in vivo in humans.
Novel therapeutics based on inhibiting the interaction of glycogen phosphorylase and G(L)-subunit of glycogen-associated protein phosphatase 1: WO2009127723.
Hypertension
Asp905Tyr polymorphism of protein phosphatase 1 G subunit gene in hypertension.
Changes in the activity and expression of protein phosphatase-1 accompany the differential regulation of NHE3 before and after the onset of hypertension in spontaneously hypertensive rats.
Hyperthyroidism
Low-frequency stimulation induces a durable long-term depression in young adult hyperthyroid rats: the role of p38 mitogen-activated protein kinase and protein phosphatase 1.
[Phosphorylase phosphatase in the liver of hyperthyroid and hypothyroid rats]
Hypotension
Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension.
Hypothyroidism
Developmental Hypothyroxinemia Caused by Mild Iodine Deficiency Leads to HFS-Induced LTD in Rat Hippocampal CA1 Region: Involvement of AMPA Receptor.
Infections
Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression.
MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1.
PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.
Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling.
Infertility, Male
PROTEIN PHOSPHATASE 1 COMPLEXES MODULATE SPERM MOTILITY AND PRESENT NOVEL TARGETS FOR MALE INFERTILITY.
Insulin Resistance
A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin.
Asp905Tyr polymorphism of protein phosphatase 1 G subunit gene in hypertension.
Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.
Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome.
Candidate genes and late-onset type 2 diabetes mellitus. Susceptibility genes or common polymorphisms?
Digenic inheritance of severe insulin resistance in a human pedigree.
Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance.
Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background.
Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.
Peroxisome proliferator-activated receptor-gamma and insulin action: insights from human genetics.
Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity.
Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM.
The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population.
Trypsin-Mn(2+)-resistant form of type 1 protein phosphatase in human muscle.
Intellectual Disability
De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease.
Intervertebral Disc Degeneration
Effect of the adenovirus?mediated Wip1 gene on lumbar intervertebral disc degeneration in a rabbit model.
Ischemic Stroke
Association between the PPP1R3B polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke in a southern Chinese Han population.
Lafora Disease
Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation.
Leukemia
Hepatic gene expression patterns following trauma-hemorrhage: effect of posttreatment with estrogen.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Depletion of pleckstrin homology domain leucine-rich repeat protein phosphatase 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms.
Leukemia, Myeloid
Decrease of nuclear protein phosphatase 1 activity and induction of mitotic arrest and apoptosis by a marine microalgal polysaccharide in human myeloid leukemia U937 cells.
Leukemia, Myeloid, Acute
Clinical significance of low protein phosphatase-1 activity of blasts in acute myelogenous leukemia with high white cell counts.
Leukemia, T-Cell
Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia.
Liver Diseases
Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.
Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease.
Lung Neoplasms
Genetic alterations and expression of the protein phosphatase 1 genes in human cancers.
Inflammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells.
Lupus Erythematosus, Systemic
Letter to the Editor: Protein phosphatase 1 subunit Ppp1r15a/GADD34 is overexpressed in systemic lupus erythematosus and related to the expression of type I interferon response genes.
Lymphoma, T-Cell
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
Malaria
Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 in Plasmodium falciparum.
Megalencephaly
De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease.
Melanoma
Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma.
Liposomal C6 Ceramide Activates Protein Phosphatase 1 to Inhibit Melanoma Cells.
Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.
Oncogenic suppression of PHLPP1 in human melanoma.
Procyanidin C1 Inhibits Melanoma Cell Growth by Activating 67-kDa Laminin Receptor Signaling.
Memory Disorders
Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin.
Multiple Sclerosis
In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3.
Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model.
Muscle Spasticity
Activity of smooth muscle phosphatases 1 and 2A in rabbit basilar artery in vasospasm.
Mycoses
A Class IV Chitinase Is Up-Regulated by Fungal Infection and Abiotic Stresses and Associated with Slow-Canker-Growth Resistance to Cronartium ribicola in Western White Pine (Pinus monticola).
A class IV chitinase is up-regulated by fungal infection and abiotic stresses and associated with slow-canker-growth resistance to Cronartium ribicola in western white pine (Pinus monticola).
Myocardial Infarction
AAV9.I-1c Delivered via Direct Coronary Infusion in a Porcine Model of Heart Failure Improves Contractility and Mitigates Adverse Remodeling.
Effects of PP1-12, a novel protein phosphatase-1 inhibitor, on ventricular function and remodeling after myocardial infarction in rats.
Neoplasm Metastasis
Hypoxia-induced NIPP1 activation enhances metastatic potential and predicts poor prognosis in hepatocellular carcinoma.
MicroRNA-455-5p Contributes to Cholangiocarcinoma Growth and Mediates Galangin's Anti-Tumor Effects.
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
PPP1R3 gene (protein phosphatase 1) alterations in colorectal cancer and its relationship to metastasis.
Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis.
Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma.
Neoplasms
A molecular basis for different interactions of marine toxins with protein phosphatase-1. Molecular models for bound motuporin, microcystins, okadaic acid, and calyculin A.
AR-v7 protein expression is regulated by protein kinase and phosphatase.
ASPP2 links the apical lateral polarity complex to the regulation of YAP activity in epithelial cells.
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Comparative proteomics of ovarian epithelial tumors.
Correction: Liu, Y.-S.; et al. Inhibition of Protein Phosphatase 1 Stimulates Noncanonical ER Stress eIF2? Activation to Enhance Fisetin-Induced Chemosensitivity in HDAC Inhibitor-Resistant Hepatocellular Carcinoma Cells. Cancers 2019, 11, 918.
CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.
Differential regulation of human B-lymphocyte tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin (TNF-beta) production by protein phosphatase 1 and 2A inhibitor.
Effect of tumor necrosis factor-alpha on insulin action in cultured rat skeletal muscle cells.
Expression analysis of pediatric solid tumor cell lines using oligonucleotide microarrays.
Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway.
Generation of an antibody against the protein phosphatase 1 inhibitor KEPI and characterization of the epitope.
Genetic alterations and expression of the protein phosphatase 1 genes in human cancers.
Identification and characterization of a novel protein inhibitor of type 1 protein phosphatase.
Identification of apoptosis-related genes and transcription variations in response to microcystin-LR in zebrafish liver.
Increased miR-155-5p expression in dermal mesenchymal stem cells of psoriatic patients: comparing the microRNA expression profile by microarray.
Inhibition of alkaline phosphatase activity by okadaic acid, a protein phosphatase inhibitor.
Inhibition of the expression of mitogen-activated protein phosphatase-1 potentiates apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells.
IPP5, a novel inhibitor of protein phosphatase 1, suppresses tumor growth and progression of cervical carcinoma cells by inducing G2/M arrest.
Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development?
LITAF, HHEX, and DUSP1 expression in mesenchymal stem cells from patients with psoriasis.
Microcystin-LR modulates selected immune parameters and induces necrosis/apoptosis of carp leucocytes.
miR-190 promotes HCC proliferation and metastasis by targeting PHLPP1.
MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression.
Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.
Nuclear localization of CPI-17, a protein phosphatase-1 inhibitor protein, affects histone H3 phosphorylation and corresponds to proliferation of cancer and smooth muscle cells.
Okadaic acid promotes angiogenesis via activation of hypoxia-inducible factor-1.
Okadaic acid, a protein phosphatase inhibitor, induces sister-chromatid exchanges depending on the presence of bromodeoxyuridine.
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-? in rheumatoid arthritis.
Production of chemokine CXCL1/KC by okadaic acid through the nuclear factor-kappaB pathway.
Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53.
Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis.
Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma.
Proteomic analysis of cellular response to microcystin in human amnion FL cells.
Scapinin, the protein phosphatase 1 binding protein, enhances cell spreading and motility by interacting with the actin cytoskeleton.
Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells.
Stimulation of tumor necrosis factor alpha production in human monocytes by inhibitors of protein phosphatase 1 and 2A.
Synthesis and biological activity of Delta-5,6-norcantharimides: importance of the 5,6-bridge.
The antitumor drug fostriecin induces vimentin hyperphosphorylation and intermediate filament reorganization.
The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum.
The PHLPP1 N-Terminal Extension is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.
The role of the Fas/FasL signaling pathway in environmental toxicant-induced testicular cell apoptosis: An update.
The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth.
USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells.
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
[Role and mechanism of cAMP/Ca 2+ signal pathway in differentiation of bone marrow mesenchymal stem cells into neuronal cells induced by salidroside].
[Tumor promotion by inhibitors of protein phosphatase 1 and 2A]
Neoplasms, Germ Cell and Embryonal
Identification and characterization of a novel protein inhibitor of type 1 protein phosphatase.
Neuroblastoma
Expression analysis of pediatric solid tumor cell lines using oligonucleotide microarrays.
Protective effect of L-deprenyl against apoptosis induced by okadaic acid in cultured neuronal cells.
Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.
Night Blindness
Large-scale analysis of sequence tags in Xp11.4-11.3 and evaluation of candidate genes for X-linked ocular diseases.
Non-alcoholic Fatty Liver Disease
Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.
Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease.
Obesity
Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background.
Genetic studies of polymorphisms in ten non-insulin-dependent diabetes mellitus candidate genes in Tamil Indians from Pondichery.
Osteosarcoma
Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases.
Ovarian Neoplasms
Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase-1 and cyclin-dependent kinase 5 expression in ovarian cancer.
Genetic alterations and expression of the protein phosphatase 1 genes in human cancers.
Pancreatic Neoplasms
Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis.
The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer.
Parkinson Disease
Association of protein phosphatase 1 gamma 1 with spinophilin suppresses phosphatase activity in a Parkinson disease model.
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
Plasmacytoma
Chromosome 8q as the most frequent target for amplification in early gastric carcinoma.
Polycythemia
Whole-Genome Sequencing Identifies the Egl Nine Homologue 3 (egln3/phd3) and Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 (PPP1R2P1) Associated with High-Altitude Polycythemia in Tibetans at High Altitude.
Prostatic Neoplasms
AR-v7 protein expression is regulated by protein kinase and phosphatase.
MicroRNA124 regulate cell growth of prostate cancer cells by targeting iASPP.
Proteinuria
Sub-chronic microcystin-LR renal toxicity in rats fed a high fat/high cholesterol diet.
Proteostasis Deficiencies
Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model.
Psoriasis
LITAF, HHEX, and DUSP1 expression in mesenchymal stem cells from patients with psoriasis.
Reperfusion Injury
Ca2+/Calmodulin-Dependent Protein Kinase II Regulation by Inhibitor 1 of Protein Phosphatase 1 Protects Against Myocardial Ischemia-Reperfusion Injury.
Retinoblastoma
An Oct4-pRb Axis, Controlled by MiR-335, Integrates Stem Cell Self-Renewal and Cell Cycle Control.
Association of protein phosphatase-1delta with the retinoblastoma protein and reversible phosphatase activation in mitotic HeLa cells and in cells released from mitosis.
Interaction between the retinoblastoma protein and protein phosphatase 1 during the cell cycle.
Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.
Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo.
Protein phosphatase-1 activation and association with the retinoblastoma protein in colcemid-induced apoptosis.
The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis.
Rift Valley Fever
Protein Phosphatase 1? Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation.
Protein Phosphatase-1 regulates Rift Valley fever virus replication.
Sarcoma, Avian
Identification of protein phosphatases 1 and 2B as ribosomal protein S6 phosphatases in vitro and in vivo.
Phosphorylation and inactivation of protein phosphatase 1 by pp60v-src.
Sarcoma, Ewing
Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis.
Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma.
Spasm
De novo PHACTR1 mutations in West syndrome and their pathophysiological effects.
Spasms, Infantile
De novo PHACTR1 mutations in West syndrome and their pathophysiological effects.
Starvation
A dual role for PP1 in shaping the Msn2-dependent transcriptional response to glucose starvation.
Dynamics and regulation of glycolysis-tricarboxylic acid metabolism in the midgut of Spodoptera litura during metamorphosis.
The activity of glycogen synthase phosphatase limits hepatic glycogen deposition in the adrenalectomized starved rat.
Stomach Neoplasms
Genetic alterations and expression of the protein phosphatase 1 genes in human cancers.
Lower expression of PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) association with poor prognosis of gastric cancer.
Teratocarcinoma
Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2.
Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB).
Urinary Bladder Neoplasms
Exosome-transmitted microRNA-133b inhibited bladder cancer proliferation by upregulating dual-specificity protein phosphatase 1.
Virus Diseases
The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection.
The effect of inhibition of PP1 and TNF? signaling on pathogenesis of SARS coronavirus.
Warts
The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum.
Whooping Cough
Induction of human neutrophil chemotaxis by Candida albicans-derived beta-1,6-long glycoside side-chain-branched beta-glucan.