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Information on EC 3.1.3.16 - protein-serine/threonine phosphatase and Organism(s) Dictyostelium discoideum

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.16 protein-serine/threonine phosphatase
IUBMB Comments
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
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This record set is specific for:
Dictyostelium discoideum
Word Map
The taxonomic range for the selected organisms is: Dictyostelium discoideum
The enzyme appears in selected viruses and cellular organisms
Synonyms
calcineurin, protein phosphatase, pac-1, serine/threonine phosphatase, phosphoprotein phosphatase, dusp1, pp2ac, dusp6, pp-2a, ppm1d, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-hydroxy 3-methylglutaryl CoenzymeA reductase phosphatase
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Aspergillus awamori acid protein phosphatase
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BCKDH phosphatase
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branched-chain alpha-keto acid dehydrogenase phosphatase
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-
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calcineurin
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Calcineurin A1
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Calcineurin A2
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CaM-kinase phosphatase
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-
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CaMKPase
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casein phosphatase
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DRES10
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Fibroblast growth factor inducible protein 13
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FIN13
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Flap wing protein
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-
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HMG-CoA reductase phosphatase
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Magnesium-dependent calcium inhibitable phosphatase
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MCPP
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Microtubule star protein
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phosphatase 2A
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phosphatase 2B
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phosphatase C-II
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Phosphatase esp1
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phosphatase H-II
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phosphatase I
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phosphatase IB
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phosphatase II
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phosphatase III
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phosphatase IV
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phosphatase SP
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phosphoprotein phosphatase
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phosphopyruvate dehydrogenase phosphatase
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phosphospectrin phosphatase
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PK-Pase
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polycation modulated (PCM-) phosphatase
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PP-1A
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PP-1B
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PP-1G
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PP2A-alpha
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PP2A-beta
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PP2C
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PP2C-alpha
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PP2C-beta
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PP2C-delta
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PP2C-gamma
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Pp4
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PP5
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PP6
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PPEF
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PPN
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PPT
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protein D phosphatase
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protein phosphatase
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Protein phosphatase 1A
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Protein phosphatase 1B
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Protein phosphatase 1C
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Protein phosphatase magnesium-dependent 1 delta
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Protein phosphatase magnesium-dependent 1 gamma
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Protein phosphatase with EF calcium-binding domain
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PSPase
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Retinal degeneration C protein
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Suppressor protein SDS21
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
protein-serine/threonine-phosphate phosphohydrolase
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
CAS REGISTRY NUMBER
COMMENTARY hide
9025-75-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
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?
phosphocasein + H2O
casein + phosphate
show the reaction diagram
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?
phosphoproteins + H2O
proteins + phosphate
show the reaction diagram
phosphorylated phosphorylase alpha + H2O
phosphorylase alpha + phosphate
show the reaction diagram
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?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
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calcineurin A, strictly dependent on Mn2+ or Mg2+ or Ca2+
Mg2+
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calcineurin A, strictly dependent on Mn2+ or Mg2+ or Ca2+
Mn2+
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calcineurin A, strictly dependent on Mn2+ or Mg2+ or Ca2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8
-
Mn2+-stimulated calcineurin A
8.3
-
Mg2+-stimulated calcineurin A
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
B-subunit of phosphatase PP2A
Manually annotated by BRENDA team
A-subunit of phosphatase PP2A
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
MPL1_DICDI
834
0
94023
Swiss-Prot
MPL2_DICDI
695
0
79425
Swiss-Prot
MPL3_DICDI
856
0
95418
Swiss-Prot
PP2BA_DICDI
623
0
71393
Swiss-Prot
PPP6_DICDI
305
0
35294
Swiss-Prot
PP1_DICDI
321
0
36939
Swiss-Prot
PTEN_DICDI
533
0
59831
Swiss-Prot
DUSP1_DICDI
212
0
23476
Swiss-Prot
DUSP2_DICDI
230
0
26189
Swiss-Prot
DUSP3_DICDI
275
0
32332
Swiss-Prot
DUSP4_DICDI
394
0
44884
Swiss-Prot
PP2AA_DICDI
306
0
35186
Swiss-Prot
Y9461_DICDI
1006
0
111161
Swiss-Prot
CTDS_DICDI
306
0
35116
Swiss-Prot
Y2105_DICDI
958
1
106617
Swiss-Prot
DUSPR_DICDI
476
0
53798
Swiss-Prot
PP2AB_DICDI
312
0
35694
Swiss-Prot
SPNA_DICDI
975
0
109016
Swiss-Prot
SSU72_DICDI
214
0
24705
Swiss-Prot
PP4C_DICDI
305
0
34862
Swiss-Prot
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37000
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
55000
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
65000
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
trimer
phosphatase PP2A, catalytic subunit C, regulatory subunits A and B, 1 * 37000 + 1 * 65000 + 1 * 55000
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F269C
increased enzyme activity against phosphorylase alpha and a higher sensitivity to calculin A
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
overexpression in Dictyostelium discoideum
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hellstern, S.; Dammann, H.; Husain, Q.; Mutzel, R.
Overexpression, purification and characterization of Dictyostelium calcineurin A
Res. Microbiol.
148
335-343
1997
Dictyostelium discoideum
Manually annotated by BRENDA team
Murphy, M.B.; Levi, S.K.; Egelhoff, T.T.
Molecular characterization and immunolocalization of Dictyostelium discoideum protein phosphatase 2A
FEBS Lett.
456
7-12
1999
Dictyostelium discoideum (Q9XZE5)
Manually annotated by BRENDA team
Andrioli, L.P.; Zaini, P.A.; Viviani, W.; Da Silva, A.M.
Dictyostelium discoideum protein phosphatase-1 catalytic subunit exhibits distinct biochemical properties
Biochem. J.
373
703-711
2003
Dictyostelium discoideum (O15757)
Manually annotated by BRENDA team
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