Reference on EC 3.1.3.11 - fructose-bisphosphatase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dzugaj, A.; Kochman, M.
Purification of human liver fructose-1,6-bisphosphatase
Biochim. Biophys. Acta
614
407-412
1980
Homo sapiens
Skalecki, K.; Rakus, D.; Wisniewski, J.R.; Kolodziej, J.; Dzugaj, A.
cDNA sequence and kinetic properties of human lung fructose(1,6)bisphosphatase
Arch. Biochem. Biophys.
365
1-9
1999
Homo sapiens (P09467)
Iversen, L.F.; Brzozowski, M.; Hastrup, S.; Hubbard, R.; Kastrup, J.S.; Larsen, I.K.; Naerum, L.; Norskov-Lauridsen, L.; Rasmussen, P.B.; Thim, L.; Wiberg, F.C.; Lundgren, K.
Characterization of the allosteric binding pocket of human liver fructose-1,6-bisphosphatase by protein crystallography and inhibitor activity studies
Protein Sci.
6
971-982
1997
Homo sapiens
Skalecki, K.; Mularczyk, W.; Dzugaj, A.
Kinetic properties of D-fructose-1,6-bisphosphate 1-phosphohydrolase isolated from human muscle
Biochem. J.
310
1029-1035
1995
Homo sapiens
Adams, A.; Redden, C.; Menahem, S.
Characterization of human fructose 1,6-bisphosphatase in control and deficient tissues
J. Inherit. Metab. Dis.
13
829-848
1990
Homo sapiens
Koekemoer, T.C.; Stanton, L.A.; Oelofsen, W.
Kinetic properties of ovine adipose tissue fructose-1,6-bisphosphatase
Comp. Biochem. Physiol. B
109
443-450
1994
Oryctolagus cuniculus, Ovis aries, Homo sapiens, Rattus norvegicus
-
Zhu, D.W.; Xu, G.J.; Rehse, P.H.; Shi, R.; Zhao, F.K.; Lin, S.X.
Crystallization and preliminary crystallographic data of fructose-1,6-bisphosphatase from human muscle
Acta Crystallogr. Sect. D
57
847-849
2001
Homo sapiens
Zhang, F.W.; Zhao, F.K.; Xu, G.J.
Molecular cloning, expression and purification of muscle fructose-1,6-bisphosphatase from Zaocys dhumnades: the role of the N-terminal sequence in AMP activation at alkaline pH
Biol. Chem.
381
561-566
2000
Homo sapiens, Rattus norvegicus, Sus scrofa, Ptyas dhumnades
Wright, S.W.; Hageman, D.L.; McClure, L.D.; Carlo, A.A.; Treadway, J.L.; Mathiowetz, A.M.; Withka, J.M.; Bauer, P.H.
Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines
Bioorg. Med. Chem. Lett.
11
17-21
2001
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Rakus, D.; Skalecki, K.; Dzugaj, A.
Kinetic properties of pig (Sus scrofa domestica) and bovine (Bos taurus) D-fructose-1,6-bisphosphate 1-phosphohydrolase (F1,6BPase): liver-like isozymes in mammalian lung tissue
Comp. Biochem. Physiol. B
127
123-134
2000
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Sus scrofa domesticus
Gizak, A.; Rakus, D.; Kolodziej, J.; Zabel, M.; Ogorzalek, A.; Dzugaj, A.
Human lung fructose-1,6-bisphosphatase is localized in pneumocytes II
Histol. Histopathol.
16
53-55
2001
Homo sapiens
Gizak, A.; Rakus, D.; Dzugaj, A.
Immunohistochemical localization of human fructose-1,6-bisphosphatase in subcellular structures of myocytes
Histol. Histopathol.
18
135-142
2003
Homo sapiens
von Geldern, T.W.; Lai, C.; Gum, R.J.; Daly, M.; Sun, C.; Fry, E.H.; Abad-Zapatero, C.
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode
Bioorg. Med. Chem. Lett.
16
1811-1815
2006
Homo sapiens
Muindi, J.R.; Peng, Y.; Wilson, J.W.; Johnson, C.S.; Branch, R.A.; Trump, D.L.
Monocyte fructose 1,6-bisphosphatase and cytidine deaminase enzyme activities: potential pharmacodynamic measures of calcitriol effects in cancer patients
Cancer Chemother. Pharmacol.
59
97-104
2006
Homo sapiens
Rakus, D.; Maciaszczyk, E.; Wawrzycka, D.; Ulaszewski, S.; Eschrich, K.; Dzugaj, A.
The origin of the high sensitivity of muscle fructose 1,6-bisphosphatase towards AMP
FEBS Lett.
579
5577-5581
2005
Homo sapiens (P09467)
Yanez, A.J.; Bertinat, R.; Spichiger, C.; Carcamo, J.G.; de Los Angeles Garcia, M.; Concha, II; Nualart, F.; Slebe, J.C.
Novel expression of liver FBPase in Langerhans islets of human and rat pancreas
J. Cell. Physiol.
205
19-24
2005
Homo sapiens, Rattus norvegicus
Cazalis, R.; Chueca, A.; Sahrawy, M.; Lopez-Gorge, J.
Construction of chimeric cytosolic fructose-1,6-bisphosphatases by insertion of a chloroplastic redox regulatory cluster
J. Physiol. Biochem.
60
7-22
2004
Beta vulgaris, Homo sapiens
Lai, C.; Gum, R.J.; Daly, M.; Fry, E.H.; Hutchins, C.; Abad-Zapatero, C.; von Geldern, T.W.
Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase
Bioorg. Med. Chem. Lett.
16
1807-1810
2006
Homo sapiens, Rattus norvegicus
Sybirna, N.; Dziewulska-Szwajkowska, D.; Barska, M.; Dzugaj, A.
Mononuclear and polymorphonuclear leukocytes show increased fructose-1,6-bisphosphatase activity in patients with type 1 diabetes mellitus
Cell Biol. Int.
30
624-630
2006
Homo sapiens
van Poelje, P.D.; Dang, Q.; Erion, M.D.
Discovery of fructose-1,6-bisphosphatase inhibitors for the treatment of type 2 diabetes
Curr. Opin. Drug Discov. Devel.
10
430-437
2007
Homo sapiens
Lamont, B.J.; Visinoni, S.; Fam, B.C.; Kebede, M.; Weinrich, B.; Papapostolou, S.; Massinet, H.; Proietto, J.; Favaloro, J.; Andrikopoulos, S.
Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis
Endocrinology
147
2764-2772
2006
Homo sapiens
Erion, M.D.; Dang, Q.; Reddy, M.R.; Kasibhatla, S.R.; Huang, J.; Lipscomb, W.N.; van Poelje, P.D.
Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity
J. Am. Chem. Soc.
129
15480-15490
2007
Homo sapiens (P09467), Homo sapiens
Dang, Q.; Kasibhatla, S.R.; Reddy, K.R.; Jiang, T.; Reddy, M.R.; Potter, S.C.; Fujitaki, J.M.; van Poelje, P.D.; Huang, J.; Lipscomb, W.N.; Erion, M.D.
Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes
J. Am. Chem. Soc.
129
15491-15502
2007
Homo sapiens, Rattus norvegicus
Mutyala, R.; Reddy, R.N.; Sumakanth, M.; Reddanna, P.; Reddy, M.R.
Calculation of relative binding affinities of fructose 1,6-bisphosphatase mutants with adenosine monophosphate using free energy perturbation method
J. Comput. Chem.
28
932-937
2007
Homo sapiens
Gizak, A.; Maciaszczyk, E.; Dzugaj, A.; Eschrich, K.; Rakus, D.
Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase
Proteins
72
209-216
2008
Homo sapiens
Visinoni, S.; Fam, B.C.; Blair, A.; Rantzau, C.; Lamont, B.J.; Bouwman, R.; Watt, M.J.; Proietto, J.; Favaloro, J.M.; Andrikopoulos, S.
Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver
Am. J. Physiol. Endocrinol. Metab.
295
E1132-E1141
2008
Homo sapiens
Bigl, M.; Jandrig, B.; Horn, L.C.; Eschrich, K.
Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer
Biochem. Biophys. Res. Commun.
377
720-724
2008
Homo sapiens
Kepka, A.; Dariusz Szajda, S.; Stypu?kowska, A.; Waszkiewicz, N.; Jankowska, A.; Chojnowska, S.; Zwierz, K.
Urinary fructose-1,6-bisphosphatase activity as a marker of the damage to the renal proximal tubules in children with idiopathic nephrotic syndrome
Clin. Chem. Lab. Med.
46
831-835
2008
Homo sapiens
Kebede, M.; Favaloro, J.; Gunton, J.E.; Laybutt, D.R.; Shaw, M.; Wong, N.; Fam, B.C.; Aston-Mourney, K.; Rantzau, C.; Zulli, A.; Proietto, J.; Andrikopoulos, S.
Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function
Diabetes
57
1887-1895
2008
Homo sapiens
Dang, Q.; Kasibhatla, S.R.; Jiang, T.; Fan, K.; Liu, Y.; Taplin, F.; Schulz, W.; Cashion, D.K.; Reddy, K.R.; van Poelje, P.D.; Fujitaki, J.M.; Potter, S.C.; Erion, M.D.
Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors
J. Med. Chem.
51
4331-4339
2008
Homo sapiens, Rattus norvegicus
Tsukada, T.; Takahashi, M.; Takemoto, T.; Kanno, O.; Yamane, T.; Kawamura, S.; Nishi, T.
Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors
Bioorg. Med. Chem. Lett.
19
5909-5912
2009
Homo sapiens (P09467), Homo sapiens
Gizak, A.; Maciaszczyk-Dziubinska, E.; Jurowicz, M.; Rakus, D.
Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence
Proteins
77
262-267
2009
Homo sapiens
Hebeisen, P.; Haap, W.; Kuhn, B.; Mohr, P.; Wessel, H.P.; Zutter, U.; Kirchner, S.; Ruf, A.; Benz, J.; Joseph, C.; Alvarez-Sanchez, R.; Gubler, M.; Schott, B.; Benardeau, A.; Tozzo, E.; Kitas, E.
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase
Bioorg. Med. Chem. Lett.
21
3237-3242
2011
Homo sapiens, Mus musculus
Dang, Q.; Kasibhatla, S.R.; Xiao, W.; Liu, Y.; Dare, J.; Taplin, F.; Reddy, K.R.; Scarlato, G.R.; Gibson, T.; van Poelje, P.D.; Potter, S.C.; Erion, M.D.
Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5-adenosinemonophosphate (AMP) mimics
J. Med. Chem.
53
441-451
2010
Homo sapiens, Rattus norvegicus
Dang, Q.; Liu, Y.; Cashion, D.K.; Kasibhatla, S.R.; Jiang, T.; Taplin, F.; Jacintho, J.D.; Li, H.; Sun, Z.; Fan, Y.; Dare, J.; Tian, F.; Li, W.; Gibson, T.; Lemus, R.; van Poelje, P.D.; Potter, S.C.; Erion, M.D.
Discovery of a series of phosphonic Acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase
J. Med. Chem.
54
153-165
2011
Homo sapiens
Bie, J.; Liu, S.; Zhou, J.; Xu, B.; Shen, Z.
Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase
Bioorg. Med. Chem.
22
1850-1862
2014
Homo sapiens
Visinoni, S.; Khalid, N.F.; Joannides, C.N.; Shulkes, A.; Yim, M.; Whitehead, J.; Tiganis, T.; Lamont, B.J.; Favaloro, J.M.; Proietto, J.; Andrikopoulos, S.; Fam, B.C.
The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity
Diabetes
61
1122-1132
2012
Homo sapiens (P09467)
Liao, B.R.; He, H.B.; Yang, L.L.; Gao, L.X.; Chang, L.; Tang, J.; Li, J.Y.; Li, J.; Yang, F.
Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-diphenyl-1,3,4-oxadiazoles
Eur. J. Med. Chem.
83
15-25
2014
Homo sapiens
Pirog, M.; Gizak, A.; Rakus, D.
Changes in quaternary structure of muscle fructose-1,6-bisphosphatase regulate affinity of the enzyme to mitochondria
Int. J. Biochem. Cell Biol.
48
55-59
2014
Homo sapiens (O00757)
Li, B.; Qiu, B.; Lee, D.S.; Walton, Z.E.; Ochocki, J.D.; Mathew, L.K.; Mancuso, A.; Gade, T.P.; Keith, B.; Nissim, I.; Simon, M.C.
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
Nature
513
251-255
2014
Homo sapiens
Shi, R.; Chen, Z.Y.; Zhu, D.W.; Li, C.; Shan, Y.; Xu, G.; Lin, S.X.
Crystal structures of human muscle fructose-1,6-bisphosphatase: novel quaternary states, enhanced AMP affinity, and allosteric signal transmission pathway
PLoS ONE
8
e71242
2013
Homo sapiens (O00757), Homo sapiens
Rakus, D.; Gizak, A.; Kasprzak, A.A.; Zarzycki, M.; Maciaszczyk-Dziubinska, E.; Dzugaj, A.
The mechanism of calcium-induced inhibition of muscle fructose 1,6-bisphosphatase and destabilization of glyconeogenic complex
PLoS ONE
8
e76669
2013
Homo sapiens
Ruf, A.; Tetaz, T.; Schott, B.; Joseph, C.; Rudolph, M.
Quadruple space-group ambiguity owing to rotational and translational noncrystallographic symmetry in human liver fructose-1,6-bisphosphatase
Acta Crystallogr. Sect. D
72
1212-1224
2016
Homo sapiens (P09467), Homo sapiens
Barciszewski, J.; Wisniewski, J.; Kolodziejczyk, R.; Jaskolski, M.; Rakus, D.; Dzugaj, A.
T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure
Acta Crystallogr. Sect. D
72
536-550
2016
Homo sapiens (O00757), Homo sapiens
Li, K.; Ying, M.; Feng, D.; Du, J.; Chen, S.; Dan, B.; Wang, C.; Wang, Y.
Fructose-1,6-bisphosphatase is a novel regulator of Wnt/beta-catenin pathway in breast cancer
Biomed. Pharmacother.
84
1144-1149
2016
Homo sapiens (O00757), Homo sapiens (P09467)
Topaz, G.R.; Epiter-Smith, V.; Robolo, C.; Emad, M.; Ford, V.; Daley, J.; Byron, J.; Stieglitz, K.A.
Characterization of recombinant fructose 1,6-bisphosphatase (FBPase) gene mutations evidence of inhibition/activation of FBPase protein by gene mutation
Biosci. Rep.
39
BSR20180960
2019
Sus scrofa (P00636), Homo sapiens (P09467), Homo sapiens
Bie, J.; Liu, S.; Li, Z.; Mu, Y.; Xu, B.; Shen, Z.
Discovery of novel indole derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase
Eur. J. Med. Chem.
90
394-405
2015
Homo sapiens, Homo sapiens (P09467)
