Information on EC 3.1.3.11 - fructose-bisphosphatase and Organism(s) Homo sapiens

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Homo sapiens


The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea


The taxonomic range for the selected organisms is: Homo sapiens

EC NUMBER
COMMENTARY hide
3.1.3.11
-
RECOMMENDED NAME
GeneOntology No.
fructose-bisphosphatase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Calvin-Benson-Bassham cycle
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formaldehyde assimilation III (dihydroxyacetone cycle)
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gluconeogenesis I
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gluconeogenesis III
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glycolysis I (from glucose 6-phosphate)
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glycolysis II (from fructose 6-phosphate)
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sucrose biosynthesis I (from photosynthesis)
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glycolysis
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pentose phosphate pathway
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photosynthesis
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Glycolysis / Gluconeogenesis
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Pentose phosphate pathway
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Fructose and mannose metabolism
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Methane metabolism
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Carbon fixation in photosynthetic organisms
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Metabolic pathways
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Biosynthesis of secondary metabolites
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Microbial metabolism in diverse environments
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
D-fructose-1,6-bisphosphate 1-phosphohydrolase
The animal enzyme also acts on sedoheptulose 1,7-bisphosphate.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-52-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-fructose 1,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
show the reaction diagram
D-fructose 1,6-diphosphate + H2O
?
show the reaction diagram
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the alkaline isoenzyme may have an important role in vivo in the regulation and control of glycolysis and glyconeogenesis
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-
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D-fructose 1,6-diphosphate + H2O
D-fructose 6-phosphate + phosphate
show the reaction diagram
additional information
?
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enzyme together with phosphofructokinase plays a crucial role in metabolism of pancreatic islet cells
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-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-fructose 1,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
show the reaction diagram
D-fructose 1,6-diphosphate + H2O
?
show the reaction diagram
-
the alkaline isoenzyme may have an important role in vivo in the regulation and control of glycolysis and glyconeogenesis
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additional information
?
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enzyme together with phosphofructokinase plays a crucial role in metabolism of pancreatic islet cells
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K+
-
at 5 mM Mg2+, increasing K+ up to 140 mM are progressively inhibitory for neutral and alkaline isoenzyme from liver, muscle neutral isoenzyme is activated, 10% at 5 mM Mg2+ but inhibited at 1 mM Mg2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl)methyl dihydrogen phosphate
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(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl)phosphonic acid
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(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)methyl dihydrogen phosphate
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-
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)phosphonic acid
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(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl)methyl dihydrogen phosphate
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-
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl)phosphonic acid
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-
(2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl)methyl dihydrogen phosphate
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-
(2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl)phosphonic acid
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-
(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)methyl dihydrogen phosphate
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-
(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)phosphonic acid
-
-
(2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl)methyl dihydrogen phosphate
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-
(2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl)phosphonic acid
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(2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl)methyl dihydrogen phosphate
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(2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl)phosphonic acid
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-
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-[(3-methylbut-2-en-1-yl)oxy]phenyl]prop-2-en-1-one
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(3-Bromo-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
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IC50: 0.0017 mM
(3-Bromo-phenyl)-(6,7-dimethoxy-2-methyl-quinazolin-4-yl)-amine
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IC50: 0.0045 mM
(3-Bromo-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine
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IC50: 0.001 mM
(3-Bromo-phenyl)-(7-ethoxy-6-nitro-quinazolin-4-yl)-amine
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IC50: 0.0039 mM
(3-Bromo-phenyl)-[6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine
-
IC50: 0.0029 mM
(3-Bromo-phenyl)-[7-methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine
-
IC50: 0.0055 mM
(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
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IC50: 0.00053 mM
(3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
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IC50: 0.0016 mM
(3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine
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IC50: 0.0013 mM
(5-[2-amino-5-[(propylsulfanyl)carbonyl]-1,3-thiazol-4-yl]furan-2-yl)phosphonic acid
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(5-[4-amino-7-[3-(dimethylamino)propyl]-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl)phosphonic acid
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(6,7-Diethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine
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IC50: 0.0024 mM
(6,7-Diethoxy-quinazolin-4-yl)-(3-fluoro-phenyl)-amine
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IC50: 0.0092 mM
(6,7-Diethoxy-quinazolin-4-yl)-(3-iodo-phenyl)-amine
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IC50: 0.0021 mM
(6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine
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IC50: 0.0009 mM
2',3'-O-(2,4,6-trinitrophenyl)adenosine 5'-monophosphate
wild-type muscle enzyme, 50% inhibition at 0.00022 mM, wild-type liver enzyme, 50% inhibition at 0.0046 mM
2,5-dichloro-N-(4-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
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2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
2,5-dichloro-N-(5-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
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2,5-dichloro-N-(6-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
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2,5-dichloro-N-(6-methoxy-1,3-benzoxazol-2-yl)benzenesulfonamide
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2,5-dichloro-N-(6-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
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2,5-dichloro-N-[5-(3-furyl)-1,3-benzoxazol-2-yl]benzenesulfonamide
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2,5-dichloro-N-[5-methoxy-7-(4-methoxypyridin-3-yl)-1,3-benzoxazol-2-yl]benzenesulfonamide
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2,5-dichloro-N-[7-(3-hydroxyphenyl)-5-methoxy-1,3-benzoxazol-2-yl]benzenesulfonamide
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2,5-dichloro-N-[7-(4-hydroxyphenyl)-5-methoxy-1,3-benzoxazol-2-yl]benzenesulfonamide
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2-(2-aminoethyl)-6,7-diethoxy-N-[3-(2-methyl-1,3-thiazol-4-yl)phenyl]quinazolin-4-amine
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uncompetitive
2-(2-thienyl)-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
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2-(3-pyridyl)-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
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2-acetamido-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl dihydrogen phosphate
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2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl dihydrogen phosphate
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2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl dihydrogen phosphate
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2-amino-4-[1-(3-phosphono)phenyl]thiazole
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2-amino-4-[2-(5-(1-(3-bromophenyl)-1,3-propyl)phosphono)-furanyl]-5-isobutyl-thiazole
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2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)-phosphonamido)-furanyl]-5-isobutylthiazole
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2-amino-4-[2-(5-bis(p-acetoxybenzyl)phosphono)furanyl]-5-isobutylthiazole
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2-amino-4-[2-(5-diphenylphosphono)furanyl]-5-isobutylthiazole
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2-amino-4-[2-(5-monophenyl-monoamino-phosphono)furanyl]-5-isobutylthiazole
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2-amino-4-[2-(5-monophenylphosphono)furanyl]-5-isobutylthiazole
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2-amino-4-[2-(5-N,N'-bis((S)-1-(1-ethoxycarbonyl)ethyl)phosphonoamido)furanyl]-5-isobutylthiazole
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optimization of the diamide prodrugs of phosphonic acid leads to the identification of a new diamide, the first reported orally efficacious FBPase inhibitor
2-amino-4-[2-(5-phosphono)furanyl]-5-ethoxycarbonylthiazole
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potent FBPase inhibitor
2-amino-4-[2-(5-phosphono)furanyl]-5-isobutylthiazole
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potent FBPase inhibitor
2-amino-4-[2-(5-phosphono)furanyl]-5-phenylthiazole
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potent FBPase inhibitor
2-amino-4-[2-(5-phosphono)furanyl]-5-propylsulfanylthiazole
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potent FBPase inhibitor
2-amino-4-[2-(6-phosphono)pyridyl]thiazole
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2-amino-4-[2-[5-(1-(4-pyridyl)-1,3-propyl)phosphono]furanyl]-5-isobutylthiazole
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2-amino-4-[2-[5-bis(1-(1-ethoxycarbonyloxy)ethyl)phosphono]-furanyl]-5-isobutyl-thiazole
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2-amino-4-[2-[5-bis(ethoxycarbonyloxymethyl)phosphono]-furanyl]-5-isobutyl-thiazole
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2-amino-4-[2-[5-bis(phenoxycarbonyloxymethyl)phosphono]-furanyl]-5-isobutyl-thiazole
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2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl dihydrogen phosphate
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2-amino-5-(2,2,2-trifluoroethyl)-4-[2-(5-phosphono)furanyl]-thiazole
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2-amino-5-(2-furanyl)-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-(2-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
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2-amino-5-(2-naphthyl)-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-(2-thienyl)-4-[(N-phosphonomethyl)carbamoyl]-thiazole
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2-amino-5-(2-thienyl)-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-(3-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
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2-amino-5-(4-acetylphenyl)-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-(4-chlorophenyl)-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-(4-fluorophenyl)-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-(4-methanesulfonyl)-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-(4-methoxycarbonylphenyl)-4-[2-(5-phosphono)-furanyl]thiazole
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2-amino-5-(4-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
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2-amino-5-(4-methylthiophenyl)-4-[2-(5-phosphono)furanyl]-thiazole
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2-amino-5-(4-phenylphenyl)-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-(4-tert-butylphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
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2-amino-5-(N-morpholinyl)-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-benzyl-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-benzyloxycarbonyl-4-[2-(5-phosphono)furanyl]-thiazole
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2-amino-5-bromo-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-chloro-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-cyclobutyl-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-cyclohexyl-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-cyclohexylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
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2-amino-5-cyclopentyl-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-cyclopentylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
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2-amino-5-cyclopropylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
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2-amino-5-ethylthio-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-hydroxymethyl-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-iodo-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
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poor oral bioavailability
2-amino-5-isopropyl- 4-[1-(4-methoxy-3-phosphono)phenyl]-thiazole
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2-amino-5-isopropyl-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-isopropylthio-4-[2-(5-phosphono)furanyl]thiazole hydrobromide
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2-amino-5-methyl-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-methylsulfanyl-4-[2-(5-diethylphosphono)furanyl]thiazole
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potent FBPase inhibitor
2-amino-5-neopentyl-4-[2-(5-phosphono)furanyl]thiazole
-
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2-amino-5-phenyl- 4-[1-(4-fluoro-3-phosphono)phenyl]thiazole
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2-amino-5-phenyl-4-[2-(5-methyl-4-phosphono)oxazolyl]-thiazole
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2-amino-5-phenyl-4-[3-(1-phosphono)pyrrolyl]thiazole
-
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2-amino-5-phenylthio-4-[2-(5-phosphono)furanyl]thiazole
-
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2-amino-5-propyl- 4-[1-(4-methyl-3-phosphono)phenyl]thiazole
-
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2-amino-5-propyl-4-phosphonomethoxycarbonylthiazole
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2-amino-5-propyl-4-[1-(3-phosphono)phenyl]thiazole
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2-amino-5-propyl-4-[2-(5-phosphono)furanyl]thiazole
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2-amino-5-tert-butylthio-4-[2-(5-phosphono)furanyl]thiazole
-
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2-amino-5-[(4-morpholinyl)methyl]-4-[2-(5-phosphono)furanyl]-thiazole dihydrobromide
-
-
2-amino-5-[(N,N-dimethyl)carbamoyl]-4-[2-(5-phosphono)-furanyl]thiazole
-
-
2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl dihydrogen phosphate
-
-
2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl dihydrogen phosphate
-
-
2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl dihydrogen phosphate
-
-
2-bromo-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-bromo-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
2-carbamoyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-chloro-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-cyano-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-ethyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-hydroxymethyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-methyl-5-isobutyl-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-methylamino-5-isobutyl-4-[2-(5-hosphono)furanyl]thiazole
-
-
2-methylthio-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-phenyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-thiocarbamoyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-vinyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-[(3S,11aS)-3-(4-hydroxybenzyl)-1,4-dioxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-2-yl]-N-[2-(4-hydroxyphenyl)ethyl]pentanamide
-
uncompetitive
2-[3-methyl-5-([[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]sulfamoyl)thiophen-2-yl]ethyl acetate
-
-
2-[5-([[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]sulfamoyl)-3-methylthiophen-2-yl]ethyl acetate
-
-
3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
-
non-competitive
3-chloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
3-chloro-N-[(3,5-dichlorophenyl)carbamoyl]benzenesulfonamide
-
-
3-ethyl-5-isobutyl-7-nitro-1H-indole-2-carboxylic acid
-
molecular modeling of binding mode. The key hydrogen bonding interactions are observed between the carboxylate and residues Thr 27, Lys 112 and Arg 140, which are also recognized by the phosphate group in AMP. This hydrogen bonding network may make crucial contributions to the binding affinity. The indole ring is situated in a hydrophobic pocket involved in residues Leu30 and Leu34. The 7-nitro group interacted with the hydroxyl group of Thr31 via a hydrogen bond
4-tert-butyl-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
5-(1H-tetrazol-5-yl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)pentanamide
-
-
5-(2-hydroxyethyl)-4-methyl-N-[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
-
-
5-(2-methoxyethyl)-4-methyl-N-([6-[(methylcarbamoyl)amino]-4-(methylsulfanyl)pyridin-2-yl]carbamoyl)thiophene-2-sulfonamide
-
-
5-(2-methoxyethyl)-4-methyl-N-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
-
-
5-(2-methoxyethyl)-4-methyl-N-[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
-
-
5-(2-methoxyethyl)-N-([4-methoxy-6-[(methylcarbamoyl)amino]pyridin-2-yl]carbamoyl)-4-methylthiophene-2-sulfonamide
-
-
5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
6-hydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)hexanamide
-
-
6-oxo-6-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)hexanoic acid
-
-
anilinoquinazoline
-
low molecular weight inhibitors of enzyme that are not substrate mimics or AMP analogues
-
D-fructose 1,6-bisphosphate
-
-
diethyl (5-[4-amino-1-[(1R,2R)-bicyclo[2.2.1]hept-2-ylamino]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
-
-
diethyl (5-[4-amino-1-[3-(thiophen-3-ylmethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
-
-
diethyl (5-[4-amino-1-[4-(furan-3-ylmethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
-
-
diethyl (5-[4-amino-1-[4-(trifluoromethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
-
-
diethyl [5-(4-amino-1-benzyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
-
-
diethyl [5-(4-amino-1-ethyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
-
-
diethyl [5-(4-amino-1-methyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
-
-
diethyl [5-(4-amino-1-propyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(3-hydroxybenzyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(4-tert-butylbenzyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(biphenyl-4-ylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(cyclobutylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(cycloheptylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(cyclohexylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(cyclopentylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(cyclopropylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diphenyl [5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonate
-
non-competitive
ethyl (2S,6S)-4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide
-
-
ethyl 4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-2,2,6,6-tetramethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide (non-preferred name)
-
-
ethyl 4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide (non-preferred name)
-
-
ethyl 4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide (non-preferred name)
-
-
fructose 1,6-diphosphate
-
-
fructose 2,6-diphosphate
K+
-
at 5 mM Mg2+, increasing K+ up to 140 mM are progressively inhibitory for neutral and alkaline isoenzyme from liver, muscle neutral isoenzyme is activated, 10% at 5 mM Mg2+ but inhibited at 1 mM Mg2+
N,N'-bis(6,7-diethoxy-2,3-dihydro-1H-cyclopenta[b]quinolin-9-yl)pentane-1,5-diamine
-
uncompetitive
N-(5-bromo-1,3-benzoxazol-2-yl)-2,5-dichlorobenzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-1-methyl-1H-imidazole-4-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-2-(1H-imidazol-1-yl)benzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-2-cyanobenzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-3-nitrobenzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-4-(3-furyl)benzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-4-(trifluoromethoxy)benzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-4-fluorobenzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-4-methylbenzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)anthracene-2-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-2-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-3-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-4-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)naphthalene-2-sulfonamide
N-(5-chloro-1,3-benzoxazol-2-yl)thiophene-2-sulfonamide
-
-
N-(5-tert-butyl-1,3-benzoxazol-2-yl)-2,5-dichlorobenzenesulfonamide
-
-
N-([4-bromo-6-[(2,2,2-trifluoroethyl)amino]pyridin-2-yl]carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-([4-bromo-6-[(methylcarbamoyl)amino]pyridin-2-yl]carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3-chlorobenzenesulfonamide
-
-
N-[(6-amino-4-bromopyridin-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[(6-amino-4-methoxypyridin-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[(6-bromo-1H-indazol-4-yl)carbamoyl]-3-chlorobenzenesulfonamide
-
-
N-[(6-bromo-1H-indazol-4-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[(6-bromo-1H-indol-4-yl)carbamoyl]-3-chlorobenzenesulfonamide
-
-
N-[(7-bromoimidazo[1,2-a]pyridin-5-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[4-[[(5-chloro-1,3-benzoxazol-2-yl)amino]sulfonyl]phenyl]butanamide
-
-
N-[6-(4-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
-
non-competitive
N-[7-(3-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
-
-
N-[7-(4-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
-
-
N-[7-[3-(aminomethyl)phenyl]-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
-
-
N-[[6-amino-4-(methylsulfanyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[[6-amino-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-hydroxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N4-(3-Bromo-phenyl)-7-chloro-quinazoline-4,6-diamine
-
IC50: 0.0119 mM
NH4+
-
0.01-0.02 mM, slight activation of neutral and alkaline isoenzyme, progressive inhibition at increasing concentration
propan-2-yl 4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-9-methyl-7-oxo-3,5,8-trioxa-4-phosphadecan-1-oate 4-oxide
-
-
tert-butyl 4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-9,9-dimethyl-7-oxo-3,5,8-trioxa-4-phosphadecan-1-oate 4-oxide
-
-
Zn2+
-
0.001-0.010 mM has no significant effect, with 0.002-0.0035 mM Zn2+, in absence of EDTA, 50% inhibition, 80% inhibition by 0.01 mM Zn2+
[(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)(difluoro)methyl]phosphonic acid
-
-
[(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)methyl]phosphonic acid
-
-
[(2R,3S,4R,5R)-5-[4-(aminocarbonyl)-1H-imidazol-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate
-
-
[2-[(6-amino-8,9-dihydro-7H-purin-8-yl)amino]ethyl]phosphonate
-
-
[2-[[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]amino]ethyl]phosphonate
-
-
[3-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]propyl]phosphonate
-
-
[5-(1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-5-isobutyl-1,3-oxazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
non-competitive
[5-(2-amino-5-isobutyl-1H-imidazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-5-phenyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-5-phenyl-1,3-thiazol-4-yl)furan-2-yl]phosphonic acid
-
-
[5-(2-amino-5-propyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-5-propyl-1,3-thiazol-4-yl)thiophen-2-yl]phosphonic acid
-
-
[5-(4-amino-1-tert-butyl-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate
-
-
[5-(4-amino-1-tert-butyl-7-ethyl-5-fluoro-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate
-
-
[5-(4-amino-5-bromo-1-cyclopropyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonic acid
-
-
[5-(5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(6-amino-3-phenylpyridin-2-yl)-2-furyl]phosphonic acid
-
-
[5-(6-amino-9-tert-butyl-8,9-dihydro-7H-purin-8-yl)-2-furyl]phosphonate
-
-
[5-[2-amino-5-(2-methylpropyl)-1,3-selenazol-4-yl]furan-2-yl]phosphonic acid
-
-
[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
-
-
[5-[2-amino-5-(ethoxycarbonyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
-
-
[5-[2-amino-5-(propylsulfanyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-1-(2-ethylbutyl)-5-fluoro-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5,7-dibromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5,7-dichloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-bromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-bromo-6,7-dichloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-chloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-ethyl-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-7-phenyl-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-7-propyl-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-1-(pentan-3-yl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-7-(2-methoxyethyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-7-(3-methylbutyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-7-(4-fluorophenyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-hydroxy-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-methoxy-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-6-chloro-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-(3,3-dimethylbutyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-(4-chlorophenyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-(6-chlorohexyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-bromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-bromo-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-chloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-chloro-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-cyclopropyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-ethenyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-ethyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[5-(2-methylpropyl)-2-phenyl-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
-
-
[5-[6-amino-9-(2,2-dimethylpropyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
-
-
[5-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
-
-
[5-[6-amino-9-(2-phenylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AMP
-
20% activation at 0.001-0.002 mM of AMP at alkaline pH, KM value of 0.00018 mM at pH 7.5, 30C, recombinant enzyme
citrate
-
activates
EDTA
-
activation
His
-
activation
NH4+
-
0.01-0.02 mM, slight activation of neutral and alkaline isoenzyme, progressive inhibition at increasing concentration
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0013 - 0.0023
D-fructose 1,6-bisphosphate
0.00077 - 0.0034
fructose 1,6-diphosphate
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0014 - 24.7
D-fructose 1,6-bisphosphate
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0011
2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
0.000031 - 0.00081
AMP
0.00098 - 0.021
Ca2+
0.00013 - 0.035
D-fructose 1,6-bisphosphate
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0164
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl)methyl dihydrogen phosphate
Homo sapiens;
-
-
0.354
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl)phosphonic acid
Homo sapiens;
-
-
0.0191
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)methyl dihydrogen phosphate
Homo sapiens;
-
-
0.00932
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)phosphonic acid
Homo sapiens;
-
-
0.0215
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl)methyl dihydrogen phosphate
Homo sapiens;
-
-
0.354
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl)phosphonic acid
Homo sapiens;
-
-
0.0417
(2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl)methyl dihydrogen phosphate
Homo sapiens;
-
-
0.000169
(2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl)phosphonic acid
Homo sapiens;
-
-
0.000124
(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)methyl dihydrogen phosphate
Homo sapiens;
-
-
0.0284
(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)phosphonic acid
Homo sapiens;
-
-
0.112
(2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl)methyl dihydrogen phosphate
Homo sapiens;
-
-
0.0187
(2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl)phosphonic acid
Homo sapiens;
-
-
0.112
(2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl)methyl dihydrogen phosphate
Homo sapiens;
-
-
0.0919
(2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl)phosphonic acid
Homo sapiens;
-
-
0.00029
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-[(3-methylbut-2-en-1-yl)oxy]phenyl]prop-2-en-1-one
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0017
(3-Bromo-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
Homo sapiens;
-
IC50: 0.0017 mM
0.0045
(3-Bromo-phenyl)-(6,7-dimethoxy-2-methyl-quinazolin-4-yl)-amine
Homo sapiens;
-
IC50: 0.0045 mM
0.001
(3-Bromo-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine
Homo sapiens;
-
IC50: 0.001 mM
0.0039
(3-Bromo-phenyl)-(7-ethoxy-6-nitro-quinazolin-4-yl)-amine
Homo sapiens;
-
IC50: 0.0039 mM
0.0029
(3-Bromo-phenyl)-[6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine
Homo sapiens;
-
IC50: 0.0029 mM
0.0055
(3-Bromo-phenyl)-[7-methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine
Homo sapiens;
-
IC50: 0.0055 mM
0.00053
(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
Homo sapiens;
-
IC50: 0.00053 mM
0.0016
(3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
Homo sapiens;
-
IC50: 0.0016 mM
0.0013
(3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine
Homo sapiens;
-
IC50: 0.0013 mM
0.000858
(5-[2-amino-5-[(propylsulfanyl)carbonyl]-1,3-thiazol-4-yl]furan-2-yl)phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000055
(5-[4-amino-7-[3-(dimethylamino)propyl]-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl)phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0024
(6,7-Diethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine
Homo sapiens;
-
IC50: 0.0024 mM
0.0092
(6,7-Diethoxy-quinazolin-4-yl)-(3-fluoro-phenyl)-amine
Homo sapiens;
-
IC50: 0.0092 mM
0.0021
(6,7-Diethoxy-quinazolin-4-yl)-(3-iodo-phenyl)-amine
Homo sapiens;
-
IC50: 0.0021 mM
0.0009
(6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine
Homo sapiens;
-
IC50: 0.0009 mM
0.055
2,5-dichloro-N-(4-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens;
-
-
0.0034
2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
0.0064
2,5-dichloro-N-(5-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens;
-
-
0.0081
2,5-dichloro-N-(6-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens;
-
-
0.008
2,5-dichloro-N-(6-methoxy-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens;
-
-
0.01
2,5-dichloro-N-(6-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens;
-
-
0.004
2,5-dichloro-N-[5-(3-furyl)-1,3-benzoxazol-2-yl]benzenesulfonamide
Homo sapiens;
-
-
0.0035
2,5-dichloro-N-[5-methoxy-7-(4-methoxypyridin-3-yl)-1,3-benzoxazol-2-yl]benzenesulfonamide
Homo sapiens;
-
-
0.0017
2,5-dichloro-N-[7-(3-hydroxyphenyl)-5-methoxy-1,3-benzoxazol-2-yl]benzenesulfonamide
Homo sapiens;
-
-
0.0018
2,5-dichloro-N-[7-(4-hydroxyphenyl)-5-methoxy-1,3-benzoxazol-2-yl]benzenesulfonamide
Homo sapiens;
-
-
0.00022
2-(2-aminoethyl)-6,7-diethoxy-N-[3-(2-methyl-1,3-thiazol-4-yl)phenyl]quinazolin-4-amine
Homo sapiens;
-
uncompetitive
0.008
2-(2-thienyl)-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.005
2-(3-pyridyl)-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.01
2-acetamido-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.112
2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl dihydrogen phosphate
Homo sapiens;
-
-
0.000013
2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl dihydrogen phosphate
Homo sapiens;
-
-
0.335
2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl dihydrogen phosphate
Homo sapiens;
-
-
0.0013
2-amino-4-[1-(3-phosphono)phenyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.002
2-amino-4-[2-(6-phosphono)pyridyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000022
2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl dihydrogen phosphate
Homo sapiens;
-
-
0.000028
2-amino-5-(2,2,2-trifluoroethyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00004
2-amino-5-(2-furanyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000043
2-amino-5-(2-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000012
2-amino-5-(2-naphthyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.95
2-amino-5-(2-thienyl)-4-[(N-phosphonomethyl)carbamoyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000044
2-amino-5-(2-thienyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000021
2-amino-5-(3-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000032
2-amino-5-(4-acetylphenyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000013
2-amino-5-(4-chlorophenyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000016
2-amino-5-(4-fluorophenyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000041
2-amino-5-(4-methanesulfonyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000014
2-amino-5-(4-methoxycarbonylphenyl)-4-[2-(5-phosphono)-furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000022
2-amino-5-(4-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000021
2-amino-5-(4-methylthiophenyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000034
2-amino-5-(4-phenylphenyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000088
2-amino-5-(4-tert-butylphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000016
2-amino-5-(N-morpholinyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000059
2-amino-5-benzyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000015
2-amino-5-benzyloxycarbonyl-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00005
2-amino-5-bromo-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00007
2-amino-5-chloro-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000012
2-amino-5-cyclobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000021
2-amino-5-cyclohexyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000018
2-amino-5-cyclohexylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000019
2-amino-5-cyclopentyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00002
2-amino-5-cyclopentylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00001
2-amino-5-cyclopropylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000033
2-amino-5-ethylthio-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00012
2-amino-5-hydroxymethyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0001
2-amino-5-iodo-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.016
2-amino-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
-
0.21
2-amino-5-isopropyl- 4-[1-(4-methoxy-3-phosphono)phenyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00003
2-amino-5-isopropyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000024
2-amino-5-isopropylthio-4-[2-(5-phosphono)furanyl]thiazole hydrobromide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00045
2-amino-5-methyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000057
2-amino-5-neopentyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.08
2-amino-5-phenyl- 4-[1-(4-fluoro-3-phosphono)phenyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.01
2-amino-5-phenyl-4-[2-(5-methyl-4-phosphono)oxazolyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.01
2-amino-5-phenyl-4-[3-(1-phosphono)pyrrolyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0003
2-amino-5-phenylthio-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.135
2-amino-5-propyl- 4-[1-(4-methyl-3-phosphono)phenyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.05
2-amino-5-propyl-4-phosphonomethoxycarbonylthiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.25
2-amino-5-propyl-4-[1-(3-phosphono)phenyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0005
2-amino-5-propyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000024
2-amino-5-tert-butylthio-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00015
2-amino-5-[(4-morpholinyl)methyl]-4-[2-(5-phosphono)furanyl]-thiazole dihydrobromide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0017
2-amino-5-[(N,N-dimethyl)carbamoyl]-4-[2-(5-phosphono)-furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00007
2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl dihydrogen phosphate
Homo sapiens;
-
-
0.307
2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl dihydrogen phosphate
Homo sapiens;
-
-
0.146
2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl dihydrogen phosphate
Homo sapiens;
-
-
0.00008
2-bromo-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0065
2-bromo-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens;
-
-
0.00275
2-carbamoyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00018
2-chloro-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.002
2-cyano-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0004
2-ethyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00022
2-hydroxymethyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0001
2-methyl-5-isobutyl-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.001
2-methylamino-5-isobutyl-4-[2-(5-hosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00089
2-methylthio-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0135
2-phenyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0005
2-thiocarbamoyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0012
2-vinyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00187
2-[(3S,11aS)-3-(4-hydroxybenzyl)-1,4-dioxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-2-yl]-N-[2-(4-hydroxyphenyl)ethyl]pentanamide
Homo sapiens;
-
uncompetitive
0.00052
2-[3-methyl-5-([[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]sulfamoyl)thiophen-2-yl]ethyl acetate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00067
2-[5-([[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]sulfamoyl)-3-methylthiophen-2-yl]ethyl acetate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0025
3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
Homo sapiens;
-
non-competitive
0.0013
3-chloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens;
-
-
0.00064
3-chloro-N-[(3,5-dichlorophenyl)carbamoyl]benzenesulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00099
3-ethyl-5-isobutyl-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens;
-
pH 7.5, 37C
0.024
4-tert-butyl-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens;
-
-
0.00298
5-(1H-tetrazol-5-yl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)pentanamide
Homo sapiens;
-
pH 7.5, temperature not specified in the publication
0.00035
5-(2-hydroxyethyl)-4-methyl-N-[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00017
5-(2-methoxyethyl)-4-methyl-N-([6-[(methylcarbamoyl)amino]-4-(methylsulfanyl)pyridin-2-yl]carbamoyl)thiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0017
5-(2-methoxyethyl)-4-methyl-N-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00053
5-(2-methoxyethyl)-4-methyl-N-[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00022
5-(2-methoxyethyl)-N-([4-methoxy-6-[(methylcarbamoyl)amino]pyridin-2-yl]carbamoyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0005
5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00132
6-hydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)hexanamide
Homo sapiens;
-
pH 7.5, temperature not specified in the publication
0.00532
6-oxo-6-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)hexanoic acid
Homo sapiens;
-
pH 7.5, temperature not specified in the publication
0.00014 - 0.00506
AMP
0.00077 - 0.934
Ca2+
0.002
diethyl (5-[4-amino-1-[(1R,2R)-bicyclo[2.2.1]hept-2-ylamino]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.004
diethyl (5-[4-amino-1-[3-(thiophen-3-ylmethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0042
diethyl (5-[4-amino-1-[4-(furan-3-ylmethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.007
diethyl (5-[4-amino-1-[4-(trifluoromethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.005
diethyl [5-(4-amino-1-benzyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00225
diethyl [5-(4-amino-1-ethyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.006
diethyl [5-(4-amino-1-methyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0011
diethyl [5-(4-amino-1-propyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0015
diethyl [5-[4-amino-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00185
diethyl [5-[4-amino-1-(3-hydroxybenzyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0095
diethyl [5-[4-amino-1-(4-tert-butylbenzyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0025
diethyl [5-[4-amino-1-(biphenyl-4-ylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0008
diethyl [5-[4-amino-1-(cyclobutylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00325
diethyl [5-[4-amino-1-(cycloheptylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0025
diethyl [5-[4-amino-1-(cyclohexylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0015
diethyl [5-[4-amino-1-(cyclopentylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0008
diethyl [5-[4-amino-1-(cyclopropylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0026
N,N'-bis(6,7-diethoxy-2,3-dihydro-1H-cyclopenta[b]quinolin-9-yl)pentane-1,5-diamine
Homo sapiens;
-
uncompetitive
0.0019
N-(5-bromo-1,3-benzoxazol-2-yl)-2,5-dichlorobenzenesulfonamide
Homo sapiens;
-
-
0.0094
N-(5-chloro-1,3-benzoxazol-2-yl)-1-methyl-1H-imidazole-4-sulfonamide
Homo sapiens;
-
-
0.023
N-(5-chloro-1,3-benzoxazol-2-yl)-2-(1H-imidazol-1-yl)benzenesulfonamide
Homo sapiens;
-
-
0.006
N-(5-chloro-1,3-benzoxazol-2-yl)-2-cyanobenzenesulfonamide
Homo sapiens;
-
-
0.0018
N-(5-chloro-1,3-benzoxazol-2-yl)-3-nitrobenzenesulfonamide
Homo sapiens;
-
-
0.0067
N-(5-chloro-1,3-benzoxazol-2-yl)-4-(3-furyl)benzenesulfonamide
Homo sapiens;
-
-
0.0078
N-(5-chloro-1,3-benzoxazol-2-yl)-4-(trifluoromethoxy)benzenesulfonamide
Homo sapiens;
-
-
0.0028
N-(5-chloro-1,3-benzoxazol-2-yl)-4-fluorobenzenesulfonamide
Homo sapiens;
-
-
0.0062
N-(5-chloro-1,3-benzoxazol-2-yl)-4-methylbenzenesulfonamide
Homo sapiens;
-
-
0.0034
N-(5-chloro-1,3-benzoxazol-2-yl)anthracene-2-sulfonamide
Homo sapiens;
-
-
0.0077
N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens;
-
-
0.0038
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-2-sulfonamide
Homo sapiens;
-
-
0.0098
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-3-sulfonamide
Homo sapiens;
-
-
0.004
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-4-sulfonamide
Homo sapiens;
-
-
0.0025
N-(5-chloro-1,3-benzoxazol-2-yl)naphthalene-2-sulfonamide
0.013
N-(5-chloro-1,3-benzoxazol-2-yl)thiophene-2-sulfonamide
Homo sapiens;
-
-
0.032
N-(5-tert-butyl-1,3-benzoxazol-2-yl)-2,5-dichlorobenzenesulfonamide
Homo sapiens;
-
-
0.0002
N-([4-bromo-6-[(2,2,2-trifluoroethyl)amino]pyridin-2-yl]carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00008
N-([4-bromo-6-[(methylcarbamoyl)amino]pyridin-2-yl]carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00033
N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3-chlorobenzenesulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00013
N-[(6-amino-4-bromopyridin-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0004
N-[(6-amino-4-methoxypyridin-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00033
N-[(6-bromo-1H-indazol-4-yl)carbamoyl]-3-chlorobenzenesulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00014
N-[(6-bromo-1H-indazol-4-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00035
N-[(6-bromo-1H-indol-4-yl)carbamoyl]-3-chlorobenzenesulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00082
N-[(7-bromoimidazo[1,2-a]pyridin-5-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.012
N-[4-[[(5-chloro-1,3-benzoxazol-2-yl)amino]sulfonyl]phenyl]butanamide
Homo sapiens;
-
-
0.00057
N-[6-(4-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
Homo sapiens;
-
non-competitive
0.00057
N-[7-(3-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
Homo sapiens;
-
-
0.0013
N-[7-(4-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
Homo sapiens;
-
-
0.0026
N-[7-[3-(aminomethyl)phenyl]-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
Homo sapiens;
-
-
0.0018
N-[[6-amino-4-(methylsulfanyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00076
N-[[6-amino-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00042
N-[[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-hydroxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0006
N-[[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0119
N4-(3-Bromo-phenyl)-7-chloro-quinazoline-4,6-diamine
Homo sapiens;
-
IC50: 0.0119 mM
0.000047
[(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)(difluoro)methyl]phosphonic acid
Homo sapiens;
-
-
0.00084
[(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)methyl]phosphonic acid
Homo sapiens;
-
-
0.012
[(2R,3S,4R,5R)-5-[4-(aminocarbonyl)-1H-imidazol-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate
Homo sapiens;
-
-
0.5
[2-[(6-amino-8,9-dihydro-7H-purin-8-yl)amino]ethyl]phosphonate
Homo sapiens;
-
-
0.097
[2-[[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]amino]ethyl]phosphonate
Homo sapiens;
-
-
0.026
[3-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]propyl]phosphonate
Homo sapiens;
-
-
0.005
[5-(1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens;
-
-
0.00045
[5-(2-amino-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens;
-
-
0.00012
[5-(2-amino-5-isobutyl-1,3-oxazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens;
-
-
0.000016
[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens;
-
non-competitive
0.005
[5-(2-amino-5-isobutyl-1H-imidazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens;
-
-
0.000014
[5-(2-amino-5-phenyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens;
-
-
0.000014
[5-(2-amino-5-phenyl-1,3-thiazol-4-yl)furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00003
[5-(2-amino-5-propyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens;
-
-
0.01
[5-(2-amino-5-propyl-1,3-thiazol-4-yl)thiophen-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0016
[5-(4-amino-1-tert-butyl-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate
Homo sapiens;
-
-
0.00009
[5-(4-amino-1-tert-butyl-7-ethyl-5-fluoro-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate
Homo sapiens;
-
-
0.000055
[5-(4-amino-5-bromo-1-cyclopropyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0005
[5-(5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens;
-
-
0.000042
[5-(6-amino-3-phenylpyridin-2-yl)-2-furyl]phosphonic acid
Homo sapiens;
-
-
0.0022
[5-(6-amino-9-tert-butyl-8,9-dihydro-7H-purin-8-yl)-2-furyl]phosphonate
Homo sapiens;
-
-
0.000039
[5-[2-amino-5-(2-methylpropyl)-1,3-selenazol-4-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
-
0.000001 - 0.000025
[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
0.000014
[5-[2-amino-5-(ethoxycarbonyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000016
[5-[2-amino-5-(propylsulfanyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00015
[5-[4-amino-1-(2-ethylbutyl)-5-fluoro-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.001
[5-[4-amino-5,7-dibromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00045
[5-[4-amino-5,7-dichloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0004
[5-[4-amino-5-bromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.01
[5-[4-amino-5-bromo-6,7-dichloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0002
[5-[4-amino-5-chloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0025
[5-[4-amino-5-ethyl-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0001
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00009
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-7-phenyl-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0001
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-7-propyl-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00085
[5-[4-amino-5-fluoro-1-(pentan-3-yl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00008
[5-[4-amino-5-fluoro-7-(2-methoxyethyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0001
[5-[4-amino-5-fluoro-7-(3-methylbutyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00018
[5-[4-amino-5-fluoro-7-(4-fluorophenyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0005
[5-[4-amino-5-hydroxy-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0007 - 0.003
[5-[4-amino-5-methoxy-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
0.000225
[5-[4-amino-6-chloro-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00021
[5-[4-amino-7-(3,3-dimethylbutyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00009
[5-[4-amino-7-(4-chlorophenyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00007
[5-[4-amino-7-(6-chlorohexyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0004
[5-[4-amino-7-bromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00013
[5-[4-amino-7-bromo-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0009
[5-[4-amino-7-chloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0001
[5-[4-amino-7-chloro-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00006
[5-[4-amino-7-cyclopropyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00028
[5-[4-amino-7-ethenyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.000055
[5-[4-amino-7-ethyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.00056
[5-[5-(2-methylpropyl)-2-phenyl-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
Homo sapiens;
-
pH not specified in the publication, temperature not specified in the publication
0.0011
[5-[6-amino-9-(2,2-dimethylpropyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
Homo sapiens;
-
-
0.0012
[5-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
Homo sapiens;
-
-
0.005 - 0.015
[5-[6-amino-9-(2-phenylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
12.9
-
-
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8
-
mutant carrying insertion of cysteine-rich light regulatory sequence of Pisum sativum enzyme into corresponding site of Beta vulgaris enzyme
8.5
-
chimeric enzyme of C-terminal half of Beta vulgaris with C-terminal half of Pisum sativum
9
-
wild-type enzyme
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
cell line 1321N1
Manually annotated by BRENDA team
-
high expression of enzyme, especially in beta-cell
Manually annotated by BRENDA team
-
the amount of polymorphonuclear and mononuclear cells with positive FBPase immunocytochemical reaction is 57% and 68%, respectively in patients with type 1 diabetes mellitus, and 38% and 42%, respectively in healthy donors
Manually annotated by BRENDA team
-
peripheral blood monocyte; peripheral blood monocyte. baseline activity of fructose 1,6-bisphosphatase in cancer patients is 1.0 nmol/min/mg protein, and 4.4 nmol/min/mg for healthy volunteers
Manually annotated by BRENDA team
-
canaliculus and acinar cell
Manually annotated by BRENDA team
additional information
-
in tumor cell lines, demethylation with 5-aza-deoxycytidine activates the expression of both L- and M-fructose 1,6-bisphosphatase. Additional inhibition of histone deacetylase with trichostatin A further increases FBPase mRNA concentrations; when non-malignant and malignant tissue samples from the same patient are compared a correlation between an increase of FBPase promoter methylation and a decrease of FBPase mRNA levels is observed
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
-
pneumocytes II, not: pneumocytes I
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
UNIPROT
ORGANISM
Homo sapiens;
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
36000
-
4 * 36000, SDS-PAGE
144000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
-
4 * 36000, SDS-PAGE
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
crystallization inpresence of 2-propanol, polyethylene glycol and MgCl2 at pH 7.5
-
enzyme in complex with AMP, formycine monophosphate and 5-amino-4-carboxamido-1beta-D-5-phosphate-ribofuranosyl-1H-imidazole
-
three-dimensional structure of the human FBPase-2-amino-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole inhibitor complex is solved at 2.0 A resolution, hanging drop method
-
wild-type AMP-bound and product-bound complexes and mutant Q32R, to 1.6 A, 2.2 A, and 2.7 A resolution, respectively. The higher sensitivity of the muscle isozyme towards AMP originates from an additional water-mediated, H-bonded network established between AMP and the binding pocket. The tetrameric assembly of the structures deviates from the canonical R- or T-states, representing novel tetrameric assemblies
-
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70
-
half-life of neutral isoenzyme: 710 s, half-life of alkaline isoenzyme: 764 s
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
-
expression in BL21 Rosetta cell
-
expression in HL-1 cardiomyocyte
-
expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis
-
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Delta1
-
deletion of the first and the first two N-terminal amino acids of FBPase affects neither the kinetic properties of the enzyme nor its association with aldolase
DELTA10
-
deletion of the first 10 amino acids: affinity to aldolase is significantly reduced, cooperativitiy of Mg2+ activation is abolished and results in biphasic inhibition of the enzyme by AMP. Truncation lowers affinity of muscle FBPase to aldolase about 14times, making it resemble the liver isozyme, Km (D-fructose 1,6-bisphosphate) similar to wild-type
DELTA2
-
deletion of the first and the first two N-terminal amino acids of FBPase affects neither the kinetic properties of the enzyme nor its association with aldolase
DELTA3
-
deletion of the first 3 amino acids: kinetic properties similar to wild-type, affinity to aldolase is significantly reduced, Km (D-fructose 1,6-bisphosphate) similar to wild-type
DELTA4
-
deletion of the first 4 amino acids: kinetic properties similar to wild-type, affinity to aldolase is significantly reduced, mutant shows a lower sensitivity to inhibition by AMP and a little weaker activation by Mg2+, Km (D-fructose 1,6-bisphosphate) similar to wild-type
DELTA5
-
deletion of the first 5 amino acids: mutant is significantly weaker inhibited by AMP than wild-tpye, affinity to aldolase is significantly reduced, kcat and activation by Mg2+ are significantly reduced, Km (D-fructose 1,6-bisphosphate) similar to wild-type
DELTA6
-
deletion of the first 6 amino acids: mutant is significantly weaker inhibited by AMP than wild-tpye, affinity to aldolase is significantly reduced, kcat and activation by Mg2+ are significantly reduced, Km (D-fructose 1,6-bisphosphate) similar to wild-type
DELTA7
-
deletion of the first 7 amino acids: mutant is significantly weaker inhibited by AMP than wild-tpye, affinity to aldolase is significantly reduced, kcat and activation by Mg2+ are significantly reduced, Km (D-fructose 1,6-bisphosphate) similar to wild-type
DELTA8
-
deletion of the first 8 amino acids: mutant is significantly weaker inhibited by AMP than wild-tpye, affinity to aldolase is significantly reduced, kcat significantly reduced, Km (D-fructose 1,6-bisphosphate) similar to wild-type
E20K
liver enzyme, mutation towards the muscle enzyme
E20K/M177T/C179Q
liver enzyme, mutation towards the muscle enzyme
K203E
-
mutation results in a noticeable drop in the amount of cells having nuclear FBPase
K204E
-
mutation results in a noticeable drop in the amount of cells having nuclear FBPase
K205E
-
mutation results in a noticeable drop in the amount of cells having nuclear FBPase
K207E
-
mutation results in a noticeable drop in the amount of cells having nuclear FBPase
K20E
muscle enzyme, mutation towards the liver enzyme
K20E/T177M/Q179C
muscle enzyme, mutation towards the liver enzyme
M177T/C179Q
liver enzyme, mutation towards the muscle enzyme
Q32R
-
conentration of AMP required for 50% inhibition of the Q32R mutant is increased 19fold, and the cooperativity of both AMP and Mg2+ is abolished or decreased. The mutation affects the conformations of both N-terminal residues and the dynamic loop 5272
T177M/Q179C
muscle enzyme, mutation towards the liver enzyme
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
-
the enzyme is a target for drug development in treatment of type 2 diabetes mellitus
medicine
molecular biology
-
promoter methylation is involved in the regulation of expression of both FBPase isoenzymes in normal human tissues as well as in cancer