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Disease on EC 3.1.21.2 - deoxyribonuclease IV

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
The expression profile and prognostic value of APE/Ref-1 and NPM1 in high-grade serous ovarian adenocarcinoma.
Upregulation of APE/ref-1 in recurrence stage I, non small cell lung cancer.
African Swine Fever
African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages.
Contributions of an Endonuclease IV Homologue to DNA Repair in the African Swine Fever Virus.
Alzheimer Disease
HMGB1 in development and diseases of the central nervous system.
Pyruvate kinase M2 in chronic inflammations: a potpourri of crucial protein-protein interactions.
Ataxia Telangiectasia
Comparison of apurinic DNA-binding protein from an ataxia telangiectasia and a HeLa cell line. Evidence for an altered processing of apurinic/apyrimidinic endonuclease.
Biliary Tract Neoplasms
Clinical implications of APEX1 and Jagged1 as chemoresistance factors in biliary tract cancer.
Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.
Brain Injuries, Traumatic
Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice.
Brain Ischemia
Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.
Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice.
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme.
Overexpression of human copper/zinc-superoxide dismutase in transgenic animals attenuates the reduction of apurinic/apyrimidinic endonuclease expression in neurons after in vitro ischemia and after transient global cerebral ischemia.
Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis.
Brain Neoplasms
Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors.
Carcinogenesis
A comparative study of recombinant mouse and human apurinic/apyrimidinic endonuclease.
Upregulation of APE/ref-1 in recurrence stage I, non small cell lung cancer.
Carcinoma
Expression Pattern of Apurinic/Apyrimidinic Endonuclease in Sinonasal Squamous Cell Carcinoma.
Nuclear expression of apurinic/apyrimidinic endonuclease increases with progression of ovarian carcinomas.
Study of AP endonuclease (APEX1/REF1), a DNA repair enzyme, in gallbladder carcinoma.
The role of genotype/phenotype at apurinic/apyrimidinic endonuclease Rs1130409 in renal cell carcinoma.
Carcinoma, Hepatocellular
An endodeoxyribonuclease activity in nuclei from rat-ascites hepatoma.
APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.
Carcinoma, Renal Cell
The role of genotype/phenotype at apurinic/apyrimidinic endonuclease Rs1130409 in renal cell carcinoma.
Carcinoma, Squamous Cell
Expression Pattern of Apurinic/Apyrimidinic Endonuclease in Sinonasal Squamous Cell Carcinoma.
Cardiovascular Diseases
Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis.
Cholangiocarcinoma
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells.
Serum Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) Level as a Potential Biomarker of Cholangiocarcinoma.
Colonic Neoplasms
Uracil-initiated base excision DNA repair synthesis fidelity in human colon adenocarcinoma LoVo and Escherichia coli cell extracts.
Coronary Artery Disease
Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis.
Diabetic Nephropathies
The role of apurinic/apyrimidinic endonuclease on the progression of streptozotocin-induced diabetic nephropathy in rats.
Endodermal Sinus Tumor
Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors.
Endometriosis
The role of apurinic/apyrimidinic endonuclease DNA repair gene in endometriosis.
Ependymoma
Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma.
Fanconi Anemia
Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand.
Glioblastoma
Fidelity and mutational specificity of uracil-initiated base excision DNA repair synthesis in human glioblastoma cell extracts.
Uracil-initiated base excision DNA repair synthesis fidelity in human colon adenocarcinoma LoVo and Escherichia coli cell extracts.
Glioma
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.
Genes and pathways driving glioblastomas in humans and murine disease models.
Relationship between expression of a major apurinic/apyrimidinic endonuclease (APEX nuclease) and susceptibility to genotoxic agents in human glioma cell lines.
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.
Huntington Disease
HMGB1 in development and diseases of the central nervous system.
Hypersensitivity
TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.
Hypertension
Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis.
Infections
An endodeoxyribonuclease induced after infection with phage T7 bearing amber mutations in genes 3, 5, and 6.
An endodeoxyribonuclease induced in E. coli by infection with lambda-pbio transducing phages.
Bacteriophage T4 endonucleases II and IV, oppositely affected by dCMP hydroxymethylase activity, have different roles in the degradation and in the RNA polymerase-dependent replication of T4 cytosine-containing DNA.
Host DNA degradation after infection of Escherichia coli with bacteriophage T4: dependence of the alternate pathway of degradation which occurs in the absence of both T4 endonuclease II and nuclear disruption on T4 endonuclease IV.
Ischemic Stroke
The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice.
Keratosis
Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes.
Leukemia
Endodeoxyribonuclease activity associated with Rauscher murine leukemia virus.
Leukemia, Myeloid
Down-regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells.
Lung Neoplasms
Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking.
Reduced apurinic/apyrimidinic endonuclease activity enhances the antitumor activity of oxymatrine in lung cancer cells.
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.
The contribution of DNA apurinic/apyrimidinic endonuclease genotype and smoking habit to Taiwan lung cancer risk.
Upregulation of APE/ref-1 in recurrence stage I, non small cell lung cancer.
Malaria
Characterization of class II apurinic/apyrimidinic endonuclease activities in the human malaria parasite, Plasmodium falciparum.
Medulloblastoma
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.
Melanoma
Apurinic/apyrimidinic endonuclease /redox effector factor-1(APE/Ref-1) a unique target for the prevention and treatment of human melanoma.
MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1.
Melanosis
Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes.
Multiple Sclerosis
HMGB1 in development and diseases of the central nervous system.
Neoplasm Metastasis
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells.
Neoplasms
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.
Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors.
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells.
Clinical implications of APEX1 and Jagged1 as chemoresistance factors in biliary tract cancer.
DNA repair genes polymorphisms and genetic susceptibility to Philadelphia-negative myeloproliferative neoplasms in a Portuguese population: The role of base excision repair genes polymorphisms.
Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.
Enzymatically active apurinic/apyrimidinic endodeoxyribonuclease 1 is released by mammalian cells through exosomes.
Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand.
Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review.
Identification of novel heterozygous Apex 1 gene variant (Glu87Gln) in patients with head and neck cancer of Indian origin.
Implications of XRCC1, XPD and APE1 gene polymorphism in North Indian population: a comparative approach in different ethnic groups worldwide.
Knock down of the dual functional protein apurinic /apyrimidinic endonuclease 1 enhances the killing effect of hematoporphrphyrin derivative-mediated photodynamic therapy on non-small cell lung cancer cells in vitro and in a xenograft model.
Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma.
Probing and regulating the activity of cellular enzymes by using DNA tetrahedron nanostructures.
Resisting the Resistance in Cancer: Cheminformatics Studies on Short- Path Base Excision Repair Pathway Antagonists Using Supervised Learning Approaches.
Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.
The APEX1/miRNA-27a-5p axis plays key roles in progression, metastasis and targeted chemotherapy of gastric cancer.
Neurodegenerative Diseases
HMGB1 in development and diseases of the central nervous system.
Neuroectodermal Tumors, Primitive
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.
Neuroinflammatory Diseases
HMGB1 in development and diseases of the central nervous system.
Osteoarthritis
The DNA repair enzyme apurinic/apyrimidinic endonuclease (Apex nuclease) 2 has the potential to protect against down-regulation of chondrocyte activity in osteoarthritis.
Parkinson Disease
HMGB1 in development and diseases of the central nervous system.
Photosensitivity Disorders
Roles of uracil-DNA glycosylase and apyrimidinic endonucleases in the molecular 5-bromo-2'-deoxyuridine photosensitization in Escherichia coli K-12.
Sarcoma
Purification and characterization of a 39kDa apurinic/apyrimidinic endonuclease from mouse ascites sarcoma cells.
Tuberculosis
Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis.
Crystal structure of the apurinic/apyrimidinic endonuclease IV from Mycobacterium tuberculosis.
Endonuclease IV Is the major apurinic/apyrimidinic endonuclease in Mycobacterium tuberculosis and is important for protection against oxidative damage.
[Characterization of Recombinant Endonuclease IV from Mycobacterium tuberculosis].
Urinary Bladder Neoplasms
Correlation of APE1 with VEGFA and CD163+ macrophage infiltration in bladder cancer and their prognostic significance.
Uterine Cervical Neoplasms
The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer.
[The expression of APE1 and its correlation with prognostic significance after 252Cf radiotherapy in cervical cancer]
Varicocele
Apurinic/apyrimidinic endonuclease immunoreactivity in germ cells of experimental varicocele-induced rat testes.
Xeroderma Pigmentosum
DNA damage repair in bladder urothelium after the Chernobyl accident in Ukraine.
Enhancement of two apurinic/apyrimidinic endonuclease activities from normal but not xeroderma pigmentosum lymphoblastoid cells by nucleosome structure.
Implications of XRCC1, XPD and APE1 gene polymorphism in North Indian population: a comparative approach in different ethnic groups worldwide.