Disease on EC 3.1.21.10 - crossover junction endodeoxyribonuclease
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Adenocarcinoma
Exceptional response to FOLFIRINOX in a patient with pancreatic cancer and a germline RAD51C mutation.
Adenocarcinoma
Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.
Anemia
Intracellular dynamics of archaeal FANCM homologue Hef in response to halted DNA replication.
Astrocytoma
Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array.
Ataxia Telangiectasia
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Ataxia Telangiectasia
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation.
Bloom Syndrome
Aberrant chromosome morphology in human cells defective for Holliday junction resolution.
Bloom Syndrome
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Bloom Syndrome
Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.
Bloom Syndrome
Deficiency of Bloom's syndrome protein causes hypersensitivity of C. elegans to ionizing radiation but not to UV radiation, and induces p53-dependent physiological apoptosis.
Bloom Syndrome
Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis.
Bloom Syndrome
Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line.
Bloom Syndrome
Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis.
Bloom Syndrome
The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.
Bloom Syndrome
The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis.
Breast Neoplasms
17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes.
Breast Neoplasms
A HRM-based screening method detects RAD51C germ-line deleterious mutations in Spanish breast and ovarian cancer families.
Breast Neoplasms
A novel deleterious c.2656G>T MSH2 germline mutation in a Pakistani family with a phenotypic overlap of hereditary breast and ovarian cancer and Lynch syndrome.
Breast Neoplasms
Addition of triple negativity of breast cancer as an indicator for germline mutations in predisposing genes increases sensitivity of clinical selection criteria.
Breast Neoplasms
Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients.
Breast Neoplasms
Association of Breast and Ovarian Cancers With Predisposition Genes Identified by Large-Scale Sequencing.
Breast Neoplasms
Association of RAD51C germline mutations with breast cancer among Bahamians.
Breast Neoplasms
Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer.
Breast Neoplasms
Breast cancer risk and germline genomic profiling of women with neurofibromatosis type 1 who developed breast cancer.
Breast Neoplasms
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women.
Breast Neoplasms
BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer.
Breast Neoplasms
Combined tumor sequencing and case/control analyses of RAD51C in breast cancer.
Breast Neoplasms
Comprehensive Functional Characterization and Clinical Interpretation of 20 Splice-Site Variants of the RAD51C Gene.
Breast Neoplasms
Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer.
Breast Neoplasms
Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers.
Breast Neoplasms
Detection of Germline Mutations in a Cohort of 139 Patients with Bilateral Breast Cancer by Multi-Gene Panel Testing: Impact of Pathogenic Variants in Other Genes beyond BRCA1/2.
Breast Neoplasms
Effect of RAD51C expression on the chemosensitivity of E?-Myc p19Arf-/- cells and its clinical significance in breast cancer.
Breast Neoplasms
Estrogen induces RAD51C expression and localization to sites of DNA damage.
Breast Neoplasms
Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians.
Breast Neoplasms
Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing.
Breast Neoplasms
Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer.
Breast Neoplasms
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Breast Neoplasms
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.
Breast Neoplasms
Germline pathogenic variants in BRCA1, BRCA2, PALB2 and RAD51C in breast cancer women from Argentina.
Breast Neoplasms
Identification of a breast cancer family double heterozygote for RAD51C and BRCA2 gene mutations.
Breast Neoplasms
Inhibition of Mus81 by siRNA enhances sensitivity to 5-FU in breast carcinoma cell lines.
Breast Neoplasms
Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway.
Breast Neoplasms
Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families.
Breast Neoplasms
Mutation screening of RAD51C in high-risk breast and ovarian cancer families.
Breast Neoplasms
Mutation status of RAD51C, PALB2 and BRIP1 in 100 Japanese familial breast cancer cases without BRCA1 and BRCA2 mutations.
Breast Neoplasms
Noninvasive Surface Imaging of Breast Cancer in Humans using a Hand-held Optical Imager.
Breast Neoplasms
Ovarian and breast cancer risks associated with pathogenic variants in RAD51C and RAD51D.
Breast Neoplasms
Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families.
Breast Neoplasms
Prepubertal genistein exposure affects erbB2/Akt signal and reduces rat mammary tumorigenesis.
Breast Neoplasms
RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families.
Breast Neoplasms
RAD51C deletion screening identifies a recurrent gross deletion in breast cancer and ovarian cancer families.
Breast Neoplasms
RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families.
Breast Neoplasms
RAD51C mutation screening in high-risk patients from Serbian hereditary breast/ovarian cancer families.
Breast Neoplasms
RAD51C: A Novel Cancer Susceptibility Gene is linked to Fanconi Anemia and Breast Cancer.
Breast Neoplasms
Recommendations for Preventive Care for Women with Rare Genetic Cause of Breast and Ovarian Cancer.
Breast Neoplasms
Screening of Finnish RAD51C founder mutations in prostate and colorectal cancer patients.
Breast Neoplasms
Screening RAD51C nucleotide alterations in patients with a family history of breast and ovarian cancer.
Breast Neoplasms
Sequencing Analysis of SLX4/FANCP Gene in Italian Familial Breast Cancer Cases.
Breast Neoplasms
Single nucleotide polymorphisms in noncoding regions of Rad51C do not change the risk of unselected breast cancer but they modulate the level of oxidative stress and the DNA damage characteristics: a case-control study.
Breast Neoplasms
Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.
Breast Neoplasms
Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.
Breast Neoplasms
The contribution of germline predisposition gene mutations to clinical subtypes of invasive breast cancer from a clinical genetic testing cohort.
Breast Neoplasms
The other side of the coin: dissecting molecular mechanisms behind hereditary breast cancer in search of therapeutic opportunities.
Breast Neoplasms
The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer.
Breast Neoplasms
Time Trends in Receipt of Germline Genetic Testing and Results for Women Diagnosed With Breast Cancer or Ovarian Cancer, 2012-2019.
Breast Neoplasms
Value of bilateral breast cancer for identification of rare recessive at-risk alleles: evidence for the role of homozygous GEN1 c.2515_2519delAAGTT mutation.
Breast Neoplasms
[New primary malignancies after breast cancer diagnosis: interplay of genetics, risk factors and treatment modalities].
Carcinogenesis
Clinical significance of RAD51C and its contribution to ovarian carcinogenesis.
Carcinogenesis
Comprehensive role of prostate-specific antigen identified with proteomic analysis in prostate cancer.
Carcinogenesis
Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis.
Carcinogenesis
High expression of Rad51c predicts poor prognostic outcome and induces cell resistance to cisplatin and radiation in non-small cell lung cancer.
Carcinogenesis
Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53-mutant mice.
Carcinogenesis
Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.
Carcinogenesis
[The mutation and expression of MUS81 gene in laryngeal squamous cell carcinoma.]
Carcinoma
Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma.
Carcinoma
Analysis of BRCA1 and RAD51C Promoter Methylation in Italian Families at High-Risk of Breast and Ovarian Cancer.
Carcinoma
Clinical characteristics and outcomes of patients with BRCA1 or RAD51C methylated versus mutated ovarian carcinoma.
Carcinoma
In cis TP53 and RAD51C pathogenic variants may predispose to sebaceous gland carcinomas.
Carcinoma
Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53-mutant mice.
Carcinoma
Ovarian and breast cancer risks associated with pathogenic variants in RAD51C and RAD51D.
Carcinoma
Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers.
Carcinoma
Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.
Carcinoma
[The mutation and expression of MUS81 gene in laryngeal squamous cell carcinoma.]
Carcinoma, Hepatocellular
Decreased expression of methyl methansulfonate and ultraviolet-sensitive gene clone 81 (Mus81) is correlated with a poor prognosis in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Downregulation of Mus81 as a novel prognostic biomarker for patients with colorectal carcinoma.
Carcinoma, Hepatocellular
Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway.
Carcinoma, Hepatocellular
Mus81 knockdown sensitizes colon cancer cells to chemotherapeutic drugs by activating CHK1 pathway.
Carcinoma, Non-Small-Cell Lung
High expression of Rad51c predicts poor prognostic outcome and induces cell resistance to cisplatin and radiation in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
Carcinoma, Ovarian Epithelial
Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status.
Carcinoma, Ovarian Epithelial
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
Carcinoma, Ovarian Epithelial
GEN-1 in Combination with Neoadjuvant Chemotherapy for Patients with Advanced Epithelial Ovarian Cancer: A Phase I Dose-escalation Study.
Carcinoma, Ovarian Epithelial
Inhibition of MUS81 improves the chemical sensitivity of olaparib by regulating MCM2 in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
MUS81 Inhibition Increases the Sensitivity to Therapy Effect in Epithelial Ovarian Cancer via Regulating CyclinB Pathway.
Carcinoma, Ovarian Epithelial
Setting the Threshold for Surgical Prevention in Women at Increased Risk of Ovarian Cancer.
Carcinoma, Ovarian Epithelial
Targeting DNA repair and replication stress in the treatment of ovarian cancer.
Cardiac Output, Low
Superiority of endocardial versus epicardial implantation of the implantable cardioverter defibrillator (ICD).
Cleft Lip
Expanding the FANCO/RAD51C associated phenotype: Cleft lip and palate and lobar holoprosencephaly, two rare findings in Fanconi anemia.
Cockayne Syndrome
DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination.
Colonic Neoplasms
Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells.
Colonic Neoplasms
Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway.
Colonic Neoplasms
Mus81 knockdown sensitizes colon cancer cells to chemotherapeutic drugs by activating CHK1 pathway.
Colorectal Neoplasms
Downregulation of Mus81 as a novel prognostic biomarker for patients with colorectal carcinoma.
Colorectal Neoplasms
Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes.
Colorectal Neoplasms
Screening of Finnish RAD51C founder mutations in prostate and colorectal cancer patients.
Colorectal Neoplasms
[Expression of Mus81 gene in Chinese Han patients with colorectal cancer and its clinical significance].
Colorectal Neoplasms, Hereditary Nonpolyposis
Recommendations for Preventive Care for Women with Rare Genetic Cause of Breast and Ovarian Cancer.
Colorectal Neoplasms, Hereditary Nonpolyposis
Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes.
Colorectal Neoplasms, Hereditary Nonpolyposis
Time to incorporate germline multigene panel testing into breast and ovarian cancer patient care.
Congenital Abnormalities
Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair.
COVID-19
Utility of a mainstreamed genetic testing pathway in breast and ovarian cancer patients during the COVID-19 pandemic.
crossover junction endodeoxyribonuclease deficiency
A role for recombination junctions in the segregation of mitochondrial DNA in yeast.
crossover junction endodeoxyribonuclease deficiency
Deficiency of Bloom's syndrome protein causes hypersensitivity of C. elegans to ionizing radiation but not to UV radiation, and induces p53-dependent physiological apoptosis.
crossover junction endodeoxyribonuclease deficiency
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
crossover junction endodeoxyribonuclease deficiency
Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells.
crossover junction endodeoxyribonuclease deficiency
Human Rad51C deficiency destabilizes XRCC3, impairs recombination, and radiosensitizes S/G2-phase cells.
crossover junction endodeoxyribonuclease deficiency
Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.
crossover junction endodeoxyribonuclease deficiency
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.
crossover junction endodeoxyribonuclease deficiency
RAD51C-deficient cancer cells are highly sensitive to the poly (ADP-ribose) polymerase inhibitor, olaparib.
crossover junction endodeoxyribonuclease deficiency
Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.
crossover junction endodeoxyribonuclease deficiency
The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction.
Decompression Sickness
Helical phasing between DNA bends and the determination of bend direction.
Decompression Sickness
The gamma delta resolvase bends the res site into a recombinogenic complex.
Endometrial Neoplasms
Patterns and functional implications of rare germline variants across 12 cancer types.
Fanconi Anemia
Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein.
Fanconi Anemia
Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan.
Fanconi Anemia
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells.
Fanconi Anemia
Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex.
Fanconi Anemia
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
Fanconi Anemia
Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair.
Fanconi Anemia
Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer.
Fanconi Anemia
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Fanconi Anemia
Genetic evidence for ongoing balanced selection at human DNA repair genes ERCC8, FANCC, and RAD51C.
Fanconi Anemia
HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies.
Fanconi Anemia
Human Mus81 and FANCB independently contribute to repair of DNA damage during replication.
Fanconi Anemia
Identification of a breast cancer family double heterozygote for RAD51C and BRCA2 gene mutations.
Fanconi Anemia
Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.
Fanconi Anemia
Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair.
Fanconi Anemia
RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families.
Fanconi Anemia
RAD51C: A Novel Cancer Susceptibility Gene is linked to Fanconi Anemia and Breast Cancer.
Fanconi Anemia
Sequencing Analysis of SLX4/FANCP Gene in Italian Familial Breast Cancer Cases.
Fanconi Anemia
Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes.
Fanconi Anemia
Targeting DNA repair and replication stress in the treatment of ovarian cancer.
Fowlpox
Structural insights into the promiscuous DNA binding and broad substrate selectivity of fowlpox virus resolvase.
Head and Neck Neoplasms
Rad51C: A novel suppressor gene modulates the risk of head and neck cancer.
Hereditary Breast and Ovarian Cancer Syndrome
A dominant RAD51C pathogenic splicing variant predisposes to breast and ovarian cancer in the Newfoundland population due to founder effect.
Hereditary Breast and Ovarian Cancer Syndrome
Mutational analysis of RAD51C and RAD51D genes in hereditary breast and ovarian cancer families from Murcia (southeastern Spain).
Holoprosencephaly
Expanding the FANCO/RAD51C associated phenotype: Cleft lip and palate and lobar holoprosencephaly, two rare findings in Fanconi anemia.
Hypersensitivity
Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes.
Hypersensitivity
Expanding the FANCO/RAD51C associated phenotype: Cleft lip and palate and lobar holoprosencephaly, two rare findings in Fanconi anemia.
Hypersensitivity
Helicase/SUMO-targeted ubiquitin ligase Uls1 interacts with the Holliday junction resolvase Yen1.
Hypersensitivity
Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein.
Hypersensitivity
Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.
Hypersensitivity
Partial suppression of the fission yeast rqh1(-) phenotype by expression of a bacterial Holliday junction resolvase.
Hypersensitivity
Pathways of Resistance to Thymineless Death in Escherichia coli and the Function of UvrD.
Hypersensitivity
Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.
Hypersensitivity
SLX-1 Is Required for Maintaining Genomic Integrity and Promoting Meiotic Noncrossovers in the Caenorhabditis elegans Germline.
Hypersensitivity
TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.
Infections
Repair of double-strand breaks in bacteriophage T4 by a mechanism that involves extensive DNA replication.
Infections
Repression of vaccinia virus Holliday junction resolvase inhibits processing of viral DNA into unit-length genomes.
Infections
Superiority of endocardial versus epicardial implantation of the implantable cardioverter defibrillator (ICD).
Infertility
Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.
Infertility
Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana.
Infertility, Male
The rice RAD51C gene is required for the meiosis of both female and male gametocytes and the DNA repair of somatic cells.
Leukemia
The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion.
Lung Neoplasms
High expression of Rad51c predicts poor prognostic outcome and induces cell resistance to cisplatin and radiation in non-small cell lung cancer.
Lung Neoplasms
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
Lyme Disease
High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete.
Lyme Disease
Identification of the determinant conferring permissive substrate usage in the telomere resolvase, ResT.
Lyme Disease
The telomere resolvase of the Lyme disease spirochete, Borrelia burgdorferi, promotes DNA single-strand annealing and strand exchange.
Lymphatic Metastasis
The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.
Lymphatic Metastasis
[Expressions of HELQ and RAD51C in endometrial stromal sarcoma and their clinical significance].
Lymphocytosis
Multifocal paraganglioma, mycosis fungoides, and monoclonal B-cell lymphocytosis in association with RAD51C mutation.
Lymphoma
Split dose recovery studies using homologous recombination deficient gene knockout chicken B lymphocyte cells.
Marfan Syndrome
Enzymatic mutation detection (EMD) of novel mutations (R565X and R1523X) in the FBN1 gene of patients with Marfan syndrome using T4 endonuclease VII.
Muir-Torre Syndrome
In cis TP53 and RAD51C pathogenic variants may predispose to sebaceous gland carcinomas.
Mycosis Fungoides
Multifocal paraganglioma, mycosis fungoides, and monoclonal B-cell lymphocytosis in association with RAD51C mutation.
Neoplasm Metastasis
Downregulation of Mus81 as a novel prognostic biomarker for patients with colorectal carcinoma.
Neoplasm Metastasis
The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.
Neoplasm Metastasis
[Expressions of HELQ and RAD51C in endometrial stromal sarcoma and their clinical significance].
Neoplasm Metastasis
[The mutation and expression of MUS81 gene in laryngeal squamous cell carcinoma.]
Neoplasms
A HRM-based screening method detects RAD51C germ-line deleterious mutations in Spanish breast and ovarian cancer families.
Neoplasms
A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer.
Neoplasms
A phase I trial of intraperitoneal GEN-1, an IL-12 plasmid formulated with PEG-PEI-cholesterol lipopolymer, administered with pegylated liposomal doxorubicin in patients with recurrent or persistent epithelial ovarian, fallopian tube or primary peritoneal cancers: An NRG Oncology/Gynecologic Oncology Group study.
Neoplasms
Aberrant chromosome morphology in human cells defective for Holliday junction resolution.
Neoplasms
Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.
Neoplasms
Analysis of BRCA1 and RAD51C Promoter Methylation in Italian Families at High-Risk of Breast and Ovarian Cancer.
Neoplasms
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
Neoplasms
Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes.
Neoplasms
Clinical utility of hereditary cancer panel testing: Impact of PALB2, ATM, CHEK2, NBN, BRIP1, RAD51C, and RAD51D results on patient management and adherence to provider recommendations.
Neoplasms
Comprehensive Functional Characterization and Clinical Interpretation of 20 Splice-Site Variants of the RAD51C Gene.
Neoplasms
Computational investigation of possible inhibitors of the winged-helix domain of MUS81.
Neoplasms
Constitutive BRCA1 Promoter Hypermethylation Can Be a Predisposing Event in Isolated Early-Onset Breast Cancer.
Neoplasms
Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.
Neoplasms
Decreased expression of methyl methansulfonate and ultraviolet-sensitive gene clone 81 (Mus81) is correlated with a poor prognosis in patients with hepatocellular carcinoma.
Neoplasms
Deleterious somatic variants in 473 consecutive individuals with ovarian cancer: results of the observational AGO-TR1 study (NCT02222883).
Neoplasms
Detection of Germline Mutations in Patients with Epithelial Ovarian Cancer Using Multi-Gene Panels: Beyond BRCA1/2.
Neoplasms
Detection of Germline Variants in 450 Breast/Ovarian Cancer Families with a Multi-Gene Panel Including Coding and Regulatory Regions.
Neoplasms
Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis.
Neoplasms
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells.
Neoplasms
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
Neoplasms
DNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage.
Neoplasms
Down-regulation of Mus81 as a potential marker for the malignancy of gastric cancer.
Neoplasms
Downregulation of Mus81 as a novel prognostic biomarker for patients with colorectal carcinoma.
Neoplasms
Effect of GEN1 interference on the chemosensitivity of the breast cancer MCF-7 and SKBR3 cell lines.
Neoplasms
Effect of RAD51C expression on the chemosensitivity of E?-Myc p19Arf-/- cells and its clinical significance in breast cancer.
Neoplasms
Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase.
Neoplasms
Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing.
Neoplasms
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Neoplasms
Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.
Neoplasms
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Neoplasms
GEN-1 in Combination with Neoadjuvant Chemotherapy for Patients with Advanced Epithelial Ovarian Cancer: A Phase I Dose-escalation Study.
Neoplasms
Gene panel sequencing in familial Breast/Ovarian Cancer patients identifies multiple novel mutations also in genes others than BRCA1/2.
Neoplasms
Gene Panel Testing for Breast Cancer Reveals Differential Effect of Prior BRCA1/2 Probability.
Neoplasms
Gene panel testing of 5589 BRCA1/2-negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer.
Neoplasms
Genetic Predisposition to Breast and Ovarian Cancers: How Many and Which Genes to Test?
Neoplasms
Genomic hallmarks of homologous recombination deficiency in invasive breast carcinomas.
Neoplasms
Germline Mutation in MUS81 Resulting in Impaired Protein Stability is Associated with Familial Breast and Thyroid Cancer.
Neoplasms
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.
Neoplasms
Germline mutations in RAD51C and RAD51D and hereditary predisposition to ovarian cancer.
Neoplasms
High expression of Rad51c predicts poor prognostic outcome and induces cell resistance to cisplatin and radiation in non-small cell lung cancer.
Neoplasms
Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications.
Neoplasms
Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families.
Neoplasms
Identification of Mitochondrial-Related Prognostic Biomarkers Associated With Primary Bile Acid Biosynthesis and Tumor Microenvironment of Hepatocellular Carcinoma.
Neoplasms
In cis TP53 and RAD51C pathogenic variants may predispose to sebaceous gland carcinomas.
Neoplasms
In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma.
Neoplasms
Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
Neoplasms
Influence of BRCA1 Germline Mutations in the Somatic Mutational Burden of Triple-Negative Breast Cancer.
Neoplasms
Inhibition of Mus81 by siRNA enhances sensitivity to 5-FU in breast carcinoma cell lines.
Neoplasms
Long-term survival of an ovarian cancer patient harboring a RAD51C missense mutation.
Neoplasms
Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53-mutant mice.
Neoplasms
Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.
Neoplasms
Multiple genes at 17q23 undergo amplification and overexpression in breast cancer.
Neoplasms
Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway.
Neoplasms
Mus81 knockdown sensitizes colon cancer cells to chemotherapeutic drugs by activating CHK1 pathway.
Neoplasms
Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.
Neoplasms
Ovarian and breast cancer risks associated with pathogenic variants in RAD51C and RAD51D.
Neoplasms
PALB2: the hub of a network of tumor suppressors involved in DNA damage responses.
Neoplasms
Patterns and functional implications of rare germline variants across 12 cancer types.
Neoplasms
Prepubertal genistein exposure affects erbB2/Akt signal and reduces rat mammary tumorigenesis.
Neoplasms
Prevalence of deleterious germline variants in risk genes including BRCA1/2 in consecutive ovarian cancer patients (AGO-TR-1).
Neoplasms
Prevalence of PALB2 Germline Mutations in Early-onset and Familial Breast/Ovarian Cancer Patients from Pakistan.
Neoplasms
RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families.
Neoplasms
RAD51C mutation screening in high-risk patients from Serbian hereditary breast/ovarian cancer families.
Neoplasms
Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers.
Neoplasms
RAD51C-deficient cancer cells are highly sensitive to the poly (ADP-ribose) polymerase inhibitor, olaparib.
Neoplasms
RAD51C: A Novel Cancer Susceptibility Gene is linked to Fanconi Anemia and Breast Cancer.
Neoplasms
Region and amino acid residues required for Rad51C binding in the human Xrcc3 protein.
Neoplasms
Reversion Mutations with Clinical Use of PARP Inhibitors: Many Genes, Many Versions.
Neoplasms
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.
Neoplasms
Setting the Threshold for Surgical Prevention in Women at Increased Risk of Ovarian Cancer.
Neoplasms
Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation-negative early-onset and high-risk breast cancer patients.
Neoplasms
Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer.
Neoplasms
The contribution of germline predisposition gene mutations to clinical subtypes of invasive breast cancer from a clinical genetic testing cohort.
Neoplasms
The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells.
Neoplasms
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
Neoplasms
The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer.
Neoplasms
The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation.
Neoplasms
Time to incorporate germline multigene panel testing into breast and ovarian cancer patient care.
Neoplasms
Using Co-segregation and Loss of Heterozygosity Analysis to Define the Pathogenicity of Unclassified Variants in Hereditary Breast Cancer Patients.
Neoplasms
Whole Exome Sequencing in BRCA1-2 Candidate Families: The Contribution of Other Cancer Susceptibility Genes.
Neoplasms
Whole-exome sequencing of non-BRCA1/BRCA2 mutation carrier cases at high-risk for hereditary breast/ovarian cancer.
Neoplasms
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study.
Neoplasms
[Current clinical issues and recent trends in hereditary breast and ovarian cancer in Japan-genetic testing for HBOC and risk-reducing surgery].
Neoplasms
[Expression of Mus81 gene in Chinese Han patients with colorectal cancer and its clinical significance].
Neoplasms
[Expressions of HELQ and RAD51C in endometrial stromal sarcoma and their clinical significance].
Neoplasms
[New primary malignancies after breast cancer diagnosis: interplay of genetics, risk factors and treatment modalities].
Ovarian Neoplasms
A dominant RAD51C pathogenic splicing variant predisposes to breast and ovarian cancer in the Newfoundland population due to founder effect.
Ovarian Neoplasms
A HRM-based screening method detects RAD51C germ-line deleterious mutations in Spanish breast and ovarian cancer families.
Ovarian Neoplasms
Age of ovarian cancer diagnosis among BRIP1, RAD51C, and RAD51D mutation carriers identified through multi-gene panel testing.
Ovarian Neoplasms
Analysis of 30 putative BRCA1 splicing mutations in hereditary breast and ovarian cancer families identifies exonic splice site mutations that escape in silico prediction.
Ovarian Neoplasms
Analysis of BRCA1 and RAD51C Promoter Methylation in Italian Families at High-Risk of Breast and Ovarian Cancer.
Ovarian Neoplasms
Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients.
Ovarian Neoplasms
Association of Breast and Ovarian Cancers With Predisposition Genes Identified by Large-Scale Sequencing.
Ovarian Neoplasms
Association of RAD51C germline mutations with breast cancer among Bahamians.
Ovarian Neoplasms
Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer.
Ovarian Neoplasms
BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases.
Ovarian Neoplasms
Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes.
Ovarian Neoplasms
Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance.
Ovarian Neoplasms
CHEK2 c.1100delC mutation is associated with an increased risk for male breast cancer in Finnish patient population.
Ovarian Neoplasms
Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status.
Ovarian Neoplasms
Combined tumor sequencing and case/control analyses of RAD51C in breast cancer.
Ovarian Neoplasms
Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer.
Ovarian Neoplasms
Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers.
Ovarian Neoplasms
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
Ovarian Neoplasms
Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan.
Ovarian Neoplasms
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
Ovarian Neoplasms
Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase.
Ovarian Neoplasms
Estrogen induces RAD51C expression and localization to sites of DNA damage.
Ovarian Neoplasms
Frequency of mutations in a large series of clinically ascertained ovarian cancer cases tested on multi-gene panels compared to reference controls.
Ovarian Neoplasms
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Ovarian Neoplasms
Gene Panel Tumor Testing in Ovarian Cancer Patients Significantly Increases the Yield of Clinically Actionable Germline Variants beyond BRCA1/BRCA2.
Ovarian Neoplasms
Gene-panel testing of breast and ovarian cancer patients identifies a recurrent RAD51C duplication.
Ovarian Neoplasms
Germline Genetic Findings Which May Impact Therapeutic Decisions in Families with a Presumed Predisposition for Hereditary Breast and Ovarian Cancer.
Ovarian Neoplasms
Germline mutation in the RAD51B gene confers predisposition to breast cancer.
Ovarian Neoplasms
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.
Ovarian Neoplasms
Germline mutations in RAD51C and RAD51D and hereditary predisposition to ovarian cancer.
Ovarian Neoplasms
High frequency of pathogenic non-founder germline mutations in BRCA1 and BRCA2 in families with breast and ovarian cancer in a founder population.
Ovarian Neoplasms
Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer.
Ovarian Neoplasms
Inhibition of MUS81 improves the chemical sensitivity of olaparib by regulating MCM2 in epithelial ovarian cancer.
Ovarian Neoplasms
Landscape of pathogenic variations in a panel of 34 genes and cancer risk estimation from 5131 HBOC families.
Ovarian Neoplasms
Long-term survival of an ovarian cancer patient harboring a RAD51C missense mutation.
Ovarian Neoplasms
Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53-mutant mice.
Ovarian Neoplasms
Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.
Ovarian Neoplasms
MUS81 Inhibition Increases the Sensitivity to Therapy Effect in Epithelial Ovarian Cancer via Regulating CyclinB Pathway.
Ovarian Neoplasms
MUS81 is associated with cell proliferation and cisplatin sensitivity in serous ovarian cancer.
Ovarian Neoplasms
MUS81 Participates in the Progression of Serous Ovarian Cancer Associated With Dysfunctional DNA Repair System.
Ovarian Neoplasms
Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families.
Ovarian Neoplasms
Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.
Ovarian Neoplasms
Mutation screening of RAD51C in high-risk breast and ovarian cancer families.
Ovarian Neoplasms
Mutation status of RAD51C, PALB2 and BRIP1 in 100 Japanese familial breast cancer cases without BRCA1 and BRCA2 mutations.
Ovarian Neoplasms
Mutational analysis of RAD51C and RAD51D genes in hereditary breast and ovarian cancer families from Murcia (southeastern Spain).
Ovarian Neoplasms
Pathologic Findings in Breast, Fallopian Tube and Ovary Specimens in non-BRCA Hereditary Breast and/or Ovarian Cancer Syndromes: A Study of 18 Patients with Deleterious Germline Mutations in RAD51C, BARD1, BRIP1, PALB2, MUTYH or CHEK2.
Ovarian Neoplasms
Pathological features of breast and ovarian cancers in RAD51C germline mutation carriers.
Ovarian Neoplasms
Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families.
Ovarian Neoplasms
RAD51 and breast cancer susceptibility: no evidence for rare variant association in the Breast Cancer Family Registry study.
Ovarian Neoplasms
RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families.
Ovarian Neoplasms
RAD51C deletion screening identifies a recurrent gross deletion in breast cancer and ovarian cancer families.
Ovarian Neoplasms
RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families.
Ovarian Neoplasms
RAD51C germline mutations in breast and ovarian cancer cases from high-risk families.
Ovarian Neoplasms
RAD51C mutation screening in high-risk patients from Serbian hereditary breast/ovarian cancer families.
Ovarian Neoplasms
RAD51C: A Novel Cancer Susceptibility Gene is linked to Fanconi Anemia and Breast Cancer.
Ovarian Neoplasms
Recommendations for Preventive Care for Women with Rare Genetic Cause of Breast and Ovarian Cancer.
Ovarian Neoplasms
Recurrent moderate-risk mutations in Finnish breast and ovarian cancer patients.
Ovarian Neoplasms
Recurrent Mutations in BRCA1, BRCA2, RAD51C, PALB2 and CHEK2 in Polish Patients with Ovarian Cancer.
Ovarian Neoplasms
Screening of Finnish RAD51C founder mutations in prostate and colorectal cancer patients.
Ovarian Neoplasms
Screening RAD51C nucleotide alterations in patients with a family history of breast and ovarian cancer.
Ovarian Neoplasms
Single nucleotide polymorphisms in noncoding regions of Rad51C do not change the risk of unselected breast cancer but they modulate the level of oxidative stress and the DNA damage characteristics: a case-control study.
Ovarian Neoplasms
Sulfolobus tokodaii RadA paralog, stRadC2, is involved in DNA recombination via interaction with RadA and Hjc.
Ovarian Neoplasms
Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes.
Ovarian Neoplasms
Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.
Ovarian Neoplasms
The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer.
Ovarian Neoplasms
Whole Exome Sequencing in BRCA1-2 Candidate Families: The Contribution of Other Cancer Susceptibility Genes.
Pancreatic Neoplasms
Exceptional response to FOLFIRINOX in a patient with pancreatic cancer and a germline RAD51C mutation.
Paraganglioma
Multifocal paraganglioma, mycosis fungoides, and monoclonal B-cell lymphocytosis in association with RAD51C mutation.
Photophobia
Evolution of a phage RuvC endonuclease for resolution of both Holliday and branched DNA junctions.
Prostatic Neoplasms
The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells.
Relapsing Fever
Identification of the determinant conferring permissive substrate usage in the telomere resolvase, ResT.
Sarcoma
[Expressions of HELQ and RAD51C in endometrial stromal sarcoma and their clinical significance].
Sarcoma, Endometrial Stromal
[Expressions of HELQ and RAD51C in endometrial stromal sarcoma and their clinical significance].
Squamous Cell Carcinoma of Head and Neck
[The mutation and expression of MUS81 gene in laryngeal squamous cell carcinoma.]
Starvation
Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.
Starvation
[Effect of mutations for the ruvABC genes on recombination between direct DNA repairs in Escherichia coli strains carrying extended tandem duplication]
Stomach Neoplasms
Down-regulation of Mus81 as a potential marker for the malignancy of gastric cancer.
Stomach Neoplasms
Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer.
Stomach Neoplasms
RAD51C-deficient cancer cells are highly sensitive to the poly (ADP-ribose) polymerase inhibitor, olaparib.
Stomach Neoplasms
The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.
Thyroid Neoplasms
Germline Mutation in MUS81 Resulting in Impaired Protein Stability is Associated with Familial Breast and Thyroid Cancer.
Triple Negative Breast Neoplasms
A Population-Based Study of Genes Previously Implicated in Breast Cancer.
Trisomy 13 Syndrome
Expanding the FANCO/RAD51C associated phenotype: Cleft lip and palate and lobar holoprosencephaly, two rare findings in Fanconi anemia.
Tuberculosis
Mycobacterium tuberculosis RuvX is a Holliday junction resolvase formed by dimerisation of the monomeric YqgF nuclease domain.
Tuberculosis
Novel insights into ATP-Stimulated Cleavage of branched DNA and RNA Substrates through Structure-Guided Studies of the Holliday Junction Resolvase RuvX.
Urinary Bladder Neoplasms
Multi-omics Perspective on the Tumor Microenvironment based on PD-L1 and CD8 T-Cell Infiltration in Urothelial Cancer.
Urinary Tract Infections
Rapid Detection of Urinary Tract Infections via Bacterial Nuclease Activity.
Vaccinia
Repression of vaccinia virus Holliday junction resolvase inhibits processing of viral DNA into unit-length genomes.
Vaccinia
Resolution of a Holliday junction by vaccinia topoisomerase requires a spacer DNA segment 3' of the CCCTT/ cleavage sites.
Xeroderma Pigmentosum
MUS81 is associated with cell proliferation and cisplatin sensitivity in serous ovarian cancer.
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