Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of the lovastatin nonaketide synthase (EC 2.3.1.161). Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme.
The enzyme appears in viruses and cellular organisms
Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of the lovastatin nonaketide synthase (EC 2.3.1.161). Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme.
Xu, W.; Chooi, Y.; Choi, J.; Li, S.; Vederas, J.; Da Silva, N.; Tang, Y.
Finding the missing link in lovastatin biosynthesis LovG is the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover
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