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IUBMB Comments Stimulated by Mg2+ 2+ R ,3S )-2-methylmalyl-CoA (cf . EC 4.1.3.24 , malyl-CoA lyase) or other CoA esters.
Synonyms
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Mcl2
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(S)-malyl-CoA + H2O = (S)-malate + CoA
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MetaCyc
methylaspartate cycle
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(S)-malyl-CoA hydrolase
Stimulated by Mg2+ or Mn2+. The enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC 4.1.3.24, malyl-CoA lyase) or other CoA esters.
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(S)-malyl-CoA + H2O
(S)-malate + CoA
(S)-malyl-CoA + H2O
(S)-malate + CoA
Substrates: the enzyme is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation
?
(S)-malyl-CoA + H2O
(S)-malate + CoA
Substrates: (S)-malyl-CoA i.e. (3S)-3-carboxy-3-hydroxypropanoyl-CoA, the enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC 4.1.3.24, malyl-CoA lyase) or other CoA esters
?
(S)-malyl-CoA + H2O
(S)-malate + CoA
Substrates: the enzyme is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation
?
(S)-malyl-CoA + H2O
(S)-malate + CoA
Substrates: (S)-malyl-CoA i.e. (3S)-3-carboxy-3-hydroxypropanoyl-CoA, the enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC 4.1.3.24, malyl-CoA lyase) or other CoA esters
?
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(S)-malyl-CoA + H2O
(S)-malate + CoA
(S)-malyl-CoA + H2O
(S)-malate + CoA
Substrates: the enzyme is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation
?
(S)-malyl-CoA + H2O
(S)-malate + CoA
Substrates: the enzyme is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation
?
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Mg2+
10 mM, stimulated by Mg2+ or Mn2+
Mn2+
10 mM, stimulated by Mg2+ or Mn2+
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EDTA
reversible inhibition
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0.09
(S)-malyl-CoA
pH 7.5, 30°C, in the presence of divalent cations (Mg2+ or Mn2+)
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110
(S)-malyl-CoA
pH 7.5, 30°C
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1200
(S)-malyl-CoA
pH 7.5, 30°C
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200
thioester cleavage, pH 7.5, 30°C
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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physiological function
the enzyme is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation
physiological function
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the enzyme is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation
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33400
2 * or 3 * x * 33400, calculated from sequence
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2 * or 3 * x * 33400, calculated from sequence
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2 * or 3 * x * 33400, calculated from sequence
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recombinant His-tagged proteins
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expression in Escherichia coli
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Erb, T.J.; Frerichs-Revermann, L.; Fuchs, G.; Alber, B.E.
The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and (3S)-Malyl-CoA thioesterase
J. Bacteriol.
192
1249-1258
2010
Cereibacter sphaeroides (D3JV05), Cereibacter sphaeroides, Cereibacter sphaeroides DSM 158 (D3JV05)
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