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2,3-dihydroxybenzoyl-CoA + H2O
CoA + 2,3-dihydroxybenzoate
-
-
-
-
?
2,3-dihydroxybenzoyl-EntB + H2O
EntB + 2,3-dihydroxybenzoate
-
-
-
-
?
2,4-dihydroxybenzoyl-CoA + H2O
CoA + 2,4-dihydroxybenzoate
-
-
-
-
?
2-butenoyl-CoA + H2O
CoA + 2-butenoate
2-methylstearoyl-CoA + H2O
CoA + 2-methylstearate
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
synthetic substrate
-
-
?
2-trans-decenoyl-CoA + H2O
CoA + 2-trans-decenoate
-
-
-
?
3,4-dihydroxybenzoyl-CoA + H2O
CoA + 3,4-dihydroxybenzoate
-
-
-
-
?
3,4-dihydroxyphenylacetyl-CoA + H2O
CoA + 3,4-dihydroxyphenylacetate
-
-
-
?
3,5-cis-dodecadienoyl-CoA + H2O
CoA + 3,5-cis-dodecadienoic acid
-
-
-
?
3,5-cis-tetradecadienoyl-CoA + H2O
CoA + 3,5-cis-tetradecadienoic acid
-
-
-
?
3,5-dihydroxybenzoyl-CoA + H2O
CoA + 3,5-dihydroxybenzoate
-
-
-
-
?
3,5-dihydroxyphenylacetyl-CoA + H2O
CoA + 3,5-dihydroxyphenylacetate
-
-
-
?
3-hydroxy-3-methyl glutaryl-CoA + H2O
CoA + 3-hydroxy-3-methyl glutarate
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
3-hydroxybenzoyl-CoA + H2O
CoA + 3-hydroxybenzoate
3-hydroxybutyryl-CoA + H2O
CoA + 3-hydroxybutanoate
-
reaction at 4.3% the rate of acetoacetyl-CoA hydrolysis
-
-
?
3-hydroxybutyryl-CoA + H2O
CoA + 3-hydroxybutyrate
-
-
-
-
?
3-hydroxydecanoyl-CoA + H2O
CoA + 3-hydroxydecanoate
3-hydroxyhexadecanoyl-CoA + H2O
CoA + 3-hydroxyhexadecanoate
-
-
-
?
3-hydroxyphenylacetyl-CoA + H2O
CoA + 3-hydroxyphenylacetate
3-hydroxytetradecanoyl-CoA + H2O
CoA + 3-hydroxytetradecanoate
-
-
-
?
3-oxodecanoyl-CoA + H2O
CoA + 3-oxodecanoate
-
-
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
4-chlorobenzoyl-CoA + H2O
CoA + 4-chlorobenzoate
-
-
-
?
4-Hydroxybenzoyl-CoA + H2O
4-Hydroxybenzoate + CoA
4-hydroxybenzoyl-CoA + H2O
CoA + 4-hydroxybenzoate
-
-
-
-
?
4-hydroxyphenylacetyl-CoA + H2O
CoA + 4-hydroxyphenylacetate
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
-
?
8-methyl-nonanoyl-CoA + H2O
8-methylnonanoate + CoA
-
-
-
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
acetyl-CoA + H2O
acetate + CoA
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
acetyl-RifM1 + H2O
?
-
-
-
?
acetyl-S-N-acetylcysteamine
N-acetylcysteamine + acetate
acyl-CoA + H2O
CoA + a carboxylate
arachidonoyl-CoA + H2O
CoA + arachidonate
arachidoyl-CoA + H2O
CoA + arachidate
benzoyl-CoA + H2O
CoA + benzoate
beta-hydroxybutyryl-CoA + H2O
CoA + beta-hydroxybutyrate
-
-
-
?
beta-methylcrotonyl-CoA + H2O
CoA + beta-methylcrotonate
butanoyl-CoA + H2O
butanoate + CoA
-
highest specific activity of the substrates tested
-
-
?
butyryl-CoA + H2O
butanoate + CoA
butyryl-CoA + H2O
CoA + butyrate
-
24% activity compared to cezomycin-CoA
-
-
?
butyryl-[acyl-carrier protein] + H2O
butanoate + acyl-carrier protein
-
-
-
?
butyrylpanthetheine phosphate + H2O
pantetheine phosphate + butyrate
-
-
-
?
cezomycin-CoA + H2O
CoA + cezomycin
-
100% activity
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
choloyl-CoA + H2O
CoA + choloate
cis-vaccenoyl-CoA + H2O
CoA + cis-vaccenic acid
-
-
-
-
?
clofibroyl-CoA + H2O
CoA + clofibrate
-
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
decanoyl-CoA + H2O
CoA + decanoate
decanoyl-CoA + H2O
decanoate + CoA
-
-
-
-
?
dipalmitoylglycero-3-phosphocholine + H2O
?
-
-
-
-
?
DL-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
DL-3-hydroxybutyryl-CoA + H2O
?
-
-
-
-
?
DL-3-hydroxybutyryl-CoA + H2O
CoA + ?
-
-
-
?
DL-palmitoyl carnitine + H2O
palmitate + DL-carnitine
-
-
-
-
?
docosahexaenoyl-CoA + H2O
CoA + docosahexaenoate
-
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
dodecanoyl-CoA + H2O
dodecanoate + CoA
-
-
-
-
?
eicosanoyl-CoA + H2O
CoA + eicosanoate
-
-
-
-
?
eicosanoyl-CoA + H2O
CoA + eicosanoic acid
-
-
-
?
eicosapentaenoyl-CoA + H2O
CoA + eicosapentaenoate
-
-
-
-
?
gamma-linolenoyl-CoA + H2O
CoA + gamma-linolenoate
glutaryl-CoA + H2O
CoA + glutarate
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
hexanoyl-CoA + H2O
CoA + hexanoate
isobutyryl-CoA + H2O
CoA + isobutyrate
isovaleryl-CoA + H2O
CoA + isovalerate
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
lauroyl-CoA + H2O
CoA + lauric acid
-
-
-
-
?
lauroyl-CoA + H2O
CoA + lauroate
linolenoyl-CoA + H2O
CoA + linolenoate
linoleoyl-CoA
CoA + linoleate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linolate
linoleoyl-CoA + H2O
CoA + linoleate
malonyl-CoA + H2O
CoA + malonate
malonyl-S-N-acetylcysteamine
N-acetylcysteamine + malonate
methylmalonyl-CoA + H2O
CoA + methylmalonate
methylmalonyl-RifM1 + H2O
?
-
-
-
?
methylmalonyl-S-N-acetylcysteamine
N-acetylcysteamine + methylmalonate
monolauroyl sucrose + H2O
lauroate + sucrose
-
-
-
-
?
monoolein + H2O
oleate + glycerol
-
-
-
-
?
monopalmitoyl sucrose + H2O
palmitate + sucrose
-
-
-
-
?
myristoleoyl-CoA + H2O
CoA + myristoleic acid
myristoyl-CoA + H2O
CoA + myristate
myristoyl-CoA + H2O
CoA + myristic acid
N-acetylcysteamine acetate
N-acetylcysteamine + acetate
-
-
-
-
?
N-acetylcysteamine butyrate
N-acetylcysteamine + butyrate
-
-
-
-
?
N-acetylcysteamine propionate
N-acetylcysteamine + propionate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
n-butyryl-CoA + H2O
CoA + n-butyrate
n-butyryl-pantetheine phosphate + H2O
?
n-decanoyl-CoA + H2O
CoA + n-decanoate
n-hexanoyl-CoA + H2O
CoA + n-hexanoate
-
-
-
?
n-octanoyl-CoA + H2O
CoA + n-octanoate
n-propionyl-CoA + H2O
CoA + n-propionate
-
-
-
?
nafamostat + H2O
6-hydroxynaphthalene-2-carboximidamide + 4-carbamidamidobenzoic acid
-
-
-
-
?
nonanoyl-CoA + H2O
nonanoate + CoA
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
octanoyl-CoA + H2O
CoA + octanoate
octanoyl-CoA + H2O
octanoate + CoA
-
-
-
-
?
oleoyl pantetheine + H2O
oleate + pantetheine
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
oleoyl-CoA + H2O
oleate + CoA
-
-
-
-
?
oleyl-[acyl-carrier protein] + H2O
oleate + acyl-carrier protein
-
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
p-nitrophenyl butanoate + H2O
p-nitrophenol + butanoate
-
51% of the activity with p-nitrophenyl propanoate
-
-
?
p-nitrophenyl butyrate
p-nitrophenol + butyrate
-
-
-
-
?
p-nitrophenyl dodecanoate + H2O
p-nitrophenol + dodecanoate
-
8.7% of the activity with p-nitrophenyl propanoate
-
-
?
p-nitrophenyl hexanoate + H2O
p-nitrophenol + hexanoate
-
33% of the activity with p-nitrophenyl propanoate
-
-
?
p-nitrophenyl propanoate + H2O
p-nitrophenol + propanoate
-
-
-
-
?
p-nitrophenyl propionate
p-nitrophenol + propionate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleic acid
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
palmitoyl-CoA + H2O
CoA + palmitate
palmitoyl-CoA + H2O
CoA + palmitic acid
-
-
-
-
?
palmitoyl-CoA + H2O
palmitate + CoA
-
-
-
-
?
phenylacetyl-CoA + H2O
CoA + phenylacetate
polyoxyethylene sorbitan monooleate + H2O
?
-
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
propionyl-RifM1 + H2O
?
-
-
-
?
propionyl-S-N-acetylcysteamine
N-acetylcysteamine + propionate
propionyl-s-N-acetylcysteamine + H2O
CoA + ?
-
-
-
?
propionyl-[acyl-carrier protein] + H2O
propionate + acyl-carrier protein
-
-
-
?
prostaglandin F2alpha-CoA + H2O
prostaglandin F2alpha + CoA
-
-
-
?
salicylyl-CoA + H2O
CoA + salicylate
-
-
-
-
?
salicylyl-EntB + H2O
EntB + salicylate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
succinyl-CoA + H2O
CoA + succinate
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
tetradecylthioacetyl-CoA + H2O
CoA + tetradecylthioacetate
-
best substrate
-
-
?
tetradecylthiopropionyl-CoA + H2O
CoA + tetradecylthiopropionate
-
-
-
-
?
tiglyl-CoA + H2O
CoA + (2E)-2-methylbut-2-enoate
-
-
-
?
tiglyl-CoA + H2O
CoA + (2E)-2-methylbut-2-enoic acid
-
-
-
?
trihydroxycoprostanoyl-CoA + H2O
CoA + trihydroxycoprostanoate
-
-
-
?
tripalmitoylglycerol + H2O
?
-
-
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
additional information
?
-
2-butenoyl-CoA + H2O
CoA + 2-butenoate
-
-
-
?
2-butenoyl-CoA + H2O
CoA + 2-butenoate
-
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
-
-
-
-
?
3-hydroxybenzoyl-CoA + H2O
CoA + 3-hydroxybenzoate
-
-
-
-
?
3-hydroxybenzoyl-CoA + H2O
CoA + 3-hydroxybenzoate
-
-
-
?
3-hydroxydecanoyl-CoA + H2O
CoA + 3-hydroxydecanoate
-
-
-
-
?
3-hydroxydecanoyl-CoA + H2O
CoA + 3-hydroxydecanoate
-
reaction at 1.4% the rate of acetoacetyl-CoA hydrolysis
-
-
?
3-hydroxyphenylacetyl-CoA + H2O
CoA + 3-hydroxyphenylacetate
-
-
-
?
3-hydroxyphenylacetyl-CoA + H2O
CoA + 3-hydroxyphenylacetate
-
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
-
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
involved in pristanic acid beta-oxidation, scheme of the pathway
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
hydrolysis allows transport of 4,8-dimethylnonanoate from peroxisomes to mitochondria for full oxidation
-
?
4-Hydroxybenzoyl-CoA + H2O
4-Hydroxybenzoate + CoA
-
-
-
?
4-Hydroxybenzoyl-CoA + H2O
4-Hydroxybenzoate + CoA
-
-
-
?
4-hydroxyphenylacetyl-CoA + H2O
CoA + 4-hydroxyphenylacetate
-
-
-
?
4-hydroxyphenylacetyl-CoA + H2O
CoA + 4-hydroxyphenylacetate
-
-
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
-
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
-
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
8% activity compared to palmitoyl-CoA
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
best substrate
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
no activity
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
23% activity compared to cezomycin-CoA
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
23% activity compared to cezomycin-CoA
-
-
?
acetyl-CoA + H2O
CoA + acetate
poor substrate
-
?
acetyl-CoA + H2O
CoA + acetate
-
reaction at 33% the rate of acetoacetyl-CoA hydrolysis
-
-
?
acetyl-S-N-acetylcysteamine
N-acetylcysteamine + acetate
-
efficient hydrolysis, remarkable preferences for acylthioesters
-
-
?
acetyl-S-N-acetylcysteamine
N-acetylcysteamine + acetate
-
efficient hydrolysis, remarkable preferences for acylthioesters
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
prefers unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
enzyme is not linked to fatty acid oxidation
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
saturated and unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
preference for unsaturated acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
acyl-CoA of chain length C8-C18
-
?
acyl-CoA + H2O
CoA + a carboxylate
long-chain fatty-acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
involved in fatty acid metabolism
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain to very-long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
saturated and unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
specific for very-long acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
ir
acyl-CoA + H2O
CoA + a carboxylate
-
specific for acyl-CoA, S-palmitoyl-glutathione and S-palmitoyl-cysteine are no substrates
-
?
acyl-CoA + H2O
CoA + a carboxylate
involved in fatty acid metabolism
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
the enzyme is required for efficient degradation of short straight chain and branched chain fatty acids
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
most effective substrate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
involved in cholesterol metabolism
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
i.e. all-cis-5,8,11,14-eicosatetranoate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
i.e. all-cis-5,8,11,14-eicosatetranoate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
regulation, e.g. in the heart, of the enzyme is performed via beta-adrenergic receptors and their antagonists, e.g. actinomycin D
-
?
arachidoyl-CoA + H2O
CoA + arachidate
-
-
-
?
arachidoyl-CoA + H2O
CoA + arachidate
-
-
-
?
arachidoyl-CoA + H2O
CoA + arachidate
-
-
-
?
benzoyl-CoA + H2O
CoA + benzoate
-
-
-
-
?
benzoyl-CoA + H2O
CoA + benzoate
-
16% activity compared to cezomycin-CoA
-
-
?
benzoyl-CoA + H2O
CoA + benzoate
-
16% activity compared to cezomycin-CoA
-
-
?
beta-methylcrotonyl-CoA + H2O
CoA + beta-methylcrotonate
-
-
-
?
beta-methylcrotonyl-CoA + H2O
CoA + beta-methylcrotonate
-
-
-
?
beta-methylcrotonyl-CoA + H2O
CoA + beta-methylcrotonate
-
-
-
?
butyryl-CoA + H2O
butanoate + CoA
-
-
-
?
butyryl-CoA + H2O
butanoate + CoA
-
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
activity is PPARalpha-inducible
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
bile acid derivative substrate
-
-
?
choloyl-CoA + H2O
CoA + choloate
activity is PPARalpha-inducible
-
-
?
choloyl-CoA + H2O
CoA + choloate
bile acid derivative substrate
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
-
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
-
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
-
i.e. [trans]-2-butenoyl-CoA, reaction at 9.4% the rate of acetoacetyl-CoA hydrolysis
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
reaction at 89% the rate of acetoacetyl-CoA hydrolysis
-
-
?
DL-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
-
-
-
?
DL-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
-
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
best substrate
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
gamma-linolenoyl-CoA + H2O
CoA + gamma-linolenoate
-
best substrate
-
-
?
gamma-linolenoyl-CoA + H2O
CoA + gamma-linolenoate
-
-
-
-
?
glutaryl-CoA + H2O
CoA + glutarate
-
-
-
?
glutaryl-CoA + H2O
CoA + glutarate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
best substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
preferred substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
ir
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
ir
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
best substrate
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
best substrate
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
best substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
ir
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
reaction at 60% the rate of acetoacetyl-CoA hydrolysis
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
poor substrate
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
poor substrate
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
molecular dynamic simulations are carried out on the X-ray structure 3F5O with hexanoyl-CoA as the substrate
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
isobutyryl-CoA + H2O
CoA + isobutyrate
-
-
-
?
isobutyryl-CoA + H2O
CoA + isobutyrate
-
-
-
?
isobutyryl-CoA + H2O
CoA + isobutyrate
-
-
-
?
isobutyryl-CoA + H2O
CoA + isobutyrate
-
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
-
?
lauroyl-CoA + H2O
CoA + lauroate
-
-
-
?
lauroyl-CoA + H2O
CoA + lauroate
-
-
-
-
?
linolenoyl-CoA + H2O
CoA + linolenoate
-
-
-
-
?
linolenoyl-CoA + H2O
CoA + linolenoate
-
-
-
?
linolenoyl-CoA + H2O
CoA + linolenoate
-
-
-
-
?
linolenoyl-CoA + H2O
CoA + linolenoate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linolate
-
-
-
?
linoleoyl-CoA + H2O
CoA + linolate
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
20% activity compared to cezomycin-CoA
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
20% activity compared to cezomycin-CoA
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
?
malonyl-S-N-acetylcysteamine
N-acetylcysteamine + malonate
-
limited hydrolysis
-
-
?
malonyl-S-N-acetylcysteamine
N-acetylcysteamine + malonate
-
limited hydrolysis
-
-
?
methylmalonyl-CoA + H2O
CoA + methylmalonate
-
-
-
?
methylmalonyl-CoA + H2O
CoA + methylmalonate
-
-
-
?
methylmalonyl-CoA + H2O
CoA + methylmalonate
-
-
-
?
methylmalonyl-S-N-acetylcysteamine
N-acetylcysteamine + methylmalonate
-
limited hydrolysis
-
-
?
methylmalonyl-S-N-acetylcysteamine
N-acetylcysteamine + methylmalonate
-
limited hydrolysis
-
-
?
myristoleoyl-CoA + H2O
CoA + myristoleic acid
-
-
-
-
?
myristoleoyl-CoA + H2O
CoA + myristoleic acid
-
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
lower activity with myristoyl-CoA compared to stearoyl-CoA
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
?
myristoyl-CoA + H2O
CoA + myristic acid
-
-
-
-
?
myristoyl-CoA + H2O
CoA + myristic acid
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
poor substrate
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
no activity
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
reaction at 81% the rate of acetoacetyl-CoA hydrolysis
-
-
?
n-butyryl-CoA + H2O
CoA + n-butyrate
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butyrate
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butyrate
-
-
-
?
n-butyryl-pantetheine phosphate + H2O
?
-
-
-
?
n-butyryl-pantetheine phosphate + H2O
?
-
-
-
?
n-decanoyl-CoA + H2O
CoA + n-decanoate
-
-
-
?
n-decanoyl-CoA + H2O
CoA + n-decanoate
-
-
-
?
n-decanoyl-CoA + H2O
CoA + n-decanoate
-
-
-
?
n-octanoyl-CoA + H2O
CoA + n-octanoate
-
-
-
?
n-octanoyl-CoA + H2O
CoA + n-octanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
preferred substrate
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
preferred substrate
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
just slowly hydrolyzed
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
i.e. [cis]-9-octadecenoyl-CoA, reaction at 40% the rate of acetoacetyl-CoA hydrolysis
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
30.14% of the activity with p-nitrophenyl propanoate
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
best substrate
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
80783, 80785, 80791, 94478, 171023, 646115, 646125, 646128, 646129, 646131, 646134, 646140, 646141, 646144, 646162, 646164, 646167, 646169, 646171, 646173 -
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
1% activity compared to cezomycin-CoA
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
1% activity compared to cezomycin-CoA
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
phenylacetyl-CoA + H2O
CoA + phenylacetate
-
-
-
?
phenylacetyl-CoA + H2O
CoA + phenylacetate
-
-
-
?
phenylacetyl-CoA + H2O
CoA + phenylacetate
-
-
-
?
phenylacetyl-CoA + H2O
CoA + phenylacetate
-
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
?
propionyl-S-N-acetylcysteamine
N-acetylcysteamine + propionate
-
efficient hydrolysis, remarkable preferences for acylthioesters
-
-
?
propionyl-S-N-acetylcysteamine
N-acetylcysteamine + propionate
-
efficient hydrolysis, remarkable preferences for acylthioesters
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
succinyl-CoA + H2O
CoA + succinate
-
-
-
?
succinyl-CoA + H2O
CoA + succinate
-
-
-
?
succinyl-CoA + H2O
CoA + succinate
-
reaction at 33% the rate of acetoacetyl-CoA hydrolysis
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
specific for
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
best substrate
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
best substrate
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
best substrate
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
best substrate
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
-
-
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
-
i.e. [trans]-11-octadecenoyl-CoA, preferred substrate of unsaturated acyl-CoA
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
-
cis-isomer
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
-
-
-
?
additional information
?
-
-
long-chain acyl-CoAs are better substrates for thioesterase than p-nitrophenyl esters
-
-
?
additional information
?
-
-
substrate specificity alters with pH
-
-
?
additional information
?
-
-
extreme accumulation, 28fold increased compared to 0°C, of myristoyl-CoA in cells at nonpermissive temperature close to 20°C, causing growth arrest
-
-
?
additional information
?
-
decanoyl pantetheine is no substrate
-
-
?
additional information
?
-
-
the physiological role of thioesterase II in Escherichia coli is to prevent the abnormal accumulation of intracellular acyl-coenzyme A
-
-
?
additional information
?
-
the long, medium, and short chain fatty acyl-CoAs are very good substrates as are the small acyl-CoA metabolites
-
-
?
additional information
?
-
YciA is responsible for the efficient, indiscriminant CoA-regulated hydrolysis of cellular acyl-CoA thioesters in a wide range of bacteria and hypothesize that this activity may support membrane biogenesis
-
-
?
additional information
?
-
-
EntH is unable to recognize acetyl-CoA, salicylyl-N-acetylcystamine or 2,3-dihydroxybenzoyl-N-acetylcystamine
-
-
?
additional information
?
-
the long, medium, and short chain fatty acyl-CoAs are very good substrates as are the small acyl-CoA metabolites
-
-
?
additional information
?
-
the substrate activity of propionyl-s-N-acetylcysteine is negligible and that of n-butyryl-pantetheine phosphate low, it is evident YciA does not target acylated holoacyl carrier proteins or other acylated proteins as substrates
-
-
?
additional information
?
-
YciA is responsible for the efficient, indiscriminant CoA-regulated hydrolysis of cellular acyl-CoA thioesters in a wide range of bacteria and hypothesize that this activity may support membrane biogenesis
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
no sufficient evidence that acyl-CoA is also the likely substrate in vivo
-
-
?
additional information
?
-
-
enzyme binds tightly and specifically to HIV-1 Nef protein, overview
-
-
?
additional information
?
-
ACOT4 protein is active on succinyl-CoA and medium to long chain acyl-CoAs. Human ACOT4 gene has acquired the functions of three mouse genes by a functional convergent evolution
-
-
?
additional information
?
-
-
enzyme regulation
-
-
?
additional information
?
-
-
enzyme regulation by dietary manipulation
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
no activity with malonyl-CoA, ligneceroyl-CoA, and nervonoyl-CoA
-
-
?
additional information
?
-
-
no activity with 3-S-N-acetylcysteamine. The enzyme is not involved in the release of calcimycin from the polyketide megasynthase
-
-
?
additional information
?
-
-
no activity with 3-S-N-acetylcysteamine. The enzyme is not involved in the release of calcimycin from the polyketide megasynthase
-
-
?
additional information
?
-
-
ScoT associated with polyketide synthase Cpk from Streptomyces coelicolor A3 is able to hydrolyze acetyl, propionyl, and butyryl residues. ScoT is an alpha/beta hydrolase with Ser90 and His224 in its active site and it clearly prefers propionate
-
-
?
additional information
?
-
-
p-aminobenzoyl-S-N-acetylcysteamine is no proper substrate
-
-
?
additional information
?
-
-
p-aminobenzoyl-S-N-acetylcysteamine is no proper substrate
-
-
?
additional information
?
-
involved in the biosynthesis of the polyketide pikromycin
-
-
?
additional information
?
-
-
involved in the biosynthesis of the polyketide pikromycin
-
-
?
additional information
?
-
-
no substrates are malonyl-CoA, acetoacetyl glutathione, acetoacetyl N-acetylcysteamine or acetoacetyl pantetheine
-
-
?
additional information
?
-
-
MTE-II may play an important role in the pregnant porcine ovary for maintaining successful gestation
-
-
?
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1-acyl-sn-glycerol-3-phosphocholine
-
competitive inhibition at low concentration of palmitoyl-CoA
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
23% inhibition at 10 mM
13-hydroperoxyoctadecadienoic acid
-
only the mitochondrial enzyme form is inhibited, not the cytosolic one
2,2'-(decane-1,10-diyldisulfanediyl)diacetic acid
-
palmitoyl-CoA hydrolase activity, L-fraction and peroxisomes, especially of 3-thia fatty acids treated rats
2,4-dichlorophenoxyacetate
-
reduced activity in microsomes and mitochondria
3-O-methylmannose polysaccharide
-
-
-
4-chloromercuribenzoate
-
inhibitor of acyl-CoA thioesterase 2
4-Pentenoate
-
reduced activity in microsomes
5,5'-dithiobis(2-nitrobenzoate)
-
-
6-O-methylglucose polysaccharide
-
-
-
Acetyl salicylate
-
reduced activity in microsomes
AMP
-
acetyl-CoA as substrate
beta-hydroxybutyrate
-
moderately inhibits the microsomal enzyme activity
bis-(4-nitrophenyl) phosphate
-
-
Co2+
-
slightly inhibits the mitochondrial enzyme
CoA-S-S-CoA
-
competitive to acetyl-CoA; i.e. oxidized CoA, additive with NADH, kinetics
D-carnitine
-
inhibits at concentrations over 6 mM
diethyl dicarbonate
-
1 mM, complete inhibition
diisopropylfluorophosphate
dimethyl (2-hydroxy-5-nitrobenzyl) sulfonium bromide
-
1 mM, 11% inhibition
dithiothreitol
-
1 mM, 20% inhibition
dodecanoyl-CoA
-
substrate inhibition
EDTA
-
inhibits the activity of the mitochondrial enzyme at concentrations of 0.5 mM
FAD
-
slightly inhibits the microsomal enzyme
Fe2+
-
almost complete inhibition at 1 mM
FMN
-
inhibits the mitochondrial-matrix enzyme activity
fumarate
-
inhibits the mitochondrial-matrix enzyme activity
GTP
-
acetyl-CoA as substrate
hexadecanoyl-CoA
-
substrate inhibition
Ibuprofen
-
reduced activity in microsomes and mitochondria
L-carnitine
-
inhibits at concentrations over 6 mM
lysophosphatidic acid
-
-
lysophosphatidylethanolamine
-
weakly inhibitory
lysophosphatidylserine
-
weakly inhibitory
methyl methanethiosulfonate
-
slight inhibition
methylene blue
-
photooxidation
N-bromosuccinimide
-
1 mM, complete inhibition
NAD+
-
inhibits the mitochondrial-matrix enzyme
Nafamostat
-
competitive inhibition of palmitoyl-CoA hydrolytic activity
NGDA
-
isozymes CTE-I and MTE-I
nicotinic acid
-
inhibits the mitochondrial-matrix enzyme activity
nordihydroguaiaretic acid
-
inhibitor of acyl-CoA thioesterase 2
O,O-Diethyl-O-(2,4,5-trichlorophenyl)-phosphate
-
-
O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphate
-
-
O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphorothionate
-
i.e. Chloropyrifos
O,O-Dimethyl-O-(2,4,5-trichloro-1-phenyl)-phosphate
-
-
O,O-Dimethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphate
-
i.e. Fospirate
octylglucoside
-
50% inhibition at 0.3%
p-chloromercuribenzoate
-
1 mM, 12% inhibition
p-chloromercuribenzoic acid
palmitic acid
-
1 mM inhibits by 30%
palmitoyl-CoA
-
0.1 mM, 67% inhibition of nafamostat
Pb2+
-
slightly inhibits the mitochondrial enzyme
phenylmethylsulfonyl fluoride
-
0.1 mM, 43% inhibition of nafamostat hydrolysis
picrylsulfonic acid
-
1 mM, 11% inhibition
tetradecanoyl-CoA
-
substrate inhibition
unsaturated fatty acids
-
-
-
Valproate
-
reduced activity in microsomes and mitochondria
2,4-dinitrofluorobenzene
-
inhibits very slowly
2,4-dinitrofluorobenzene
-
-
4-hydroxyphenacyl-CoA
-
acetyl-CoA
-
-
acyl-CoA
-
e.g. lauroyl-CoA, at 0.005 mM, can be overcome by addition of bovine serum albumin or alpha-casein
acyl-CoA
substrate inhibition at concentrations higher than 0.005-0.01 mM of acyl-CoA longer than C10, BSA protects
ADP
-
-
ADP
-
inhibits the mitochondrial-matrix enzyme
ATP
-
inhibits ACH1 but not ACH2
ATP
-
inhibits the mitochondrial-matrix enzyme
ATP
-
competitive to acetyl-CoA
bovine serum albumin
-
-
-
bovine serum albumin
-
octadecanoyl-CoA as substrate, stimulates with C-6 to C-12 CoA as substrates
-
bovine serum albumin
-
-
-
bovine serum albumin
-
-
-
bovine serum albumin
-
a high amount inhibits the hydrolase
-
bovine serum albumin
-
-
-
bovine serum albumin
-
a high amount inhibits the hydrolase
-
Ca2+
-
weakly inhibitory
Ca2+
-
inhibits ACH1, but ACH 2 just at higher concentrations
Ca2+
-
50% inhibition at 1.6 mM
Ca2+
-
inhibits the microsomal enzyme
Ca2+
-
10 mM inhibits the enzyme by 30-35%
Clofibrate
-
-
Clofibrate
-
reduced activity of the mitochondrial enzyme
CoA
strong feedback inhibitor, product inhibition
CoA
strong feedback inhibitor, product inhibition
CoASH
-
feedback inhibition of recombinant enzyme at concentrations above 0.1 mM
CoASH
-
product inhibition, acetyl-CoA as substrate, kinetics
Cu2+
-
-
diethyldicarbonate
-
95% inhibition at 2 mM
diethyldicarbonate
hydroxylamine reverses
diethyldicarbonate
-
hydroxylamine reverses
diethyldicarbonate
-
inactivation
diisopropylfluorophosphate
-
94% inhibition at 5 mM, maximal inhibition
diisopropylfluorophosphate
-
complete inhibition
diisopropylfluorophosphate
-
0.01 mM inhibits
diisopropylfluorophosphate
-
no inhibition
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
at 0.01 mM inhibition of 95% after 40 min.
diisopropylfluorophosphate
-
1 mM DFP at 40 min at 25°C produces a 95% inhibition at palmityl thioesterase I
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
1 mM inhibits activity completely
diisopropylfluorophosphate
-
-
hexyl-CoA
-
iodoacetamide
-
-
KCl
-
-
KCl
-
inhibits at high concentrations
KCl
-
inhibits the mitochondrial enzyme above 125 mM
L-palmitoyl carnitine
-
competitively inhibits at 0.02-04 mM
L-palmitoyl carnitine
-
competitive to acyl-CoA
lysophosphatidylcholine
-
strongly inhibitory
lysophosphatidylcholine
-
-
lysophosphatidylinositol
-
strong inhibition
lysophosphatidylinositol
-
-
Mg2+
-
weak inhibition
Mg2+
-
0.5 mM gives 40% inhibition
Mg2+
-
inhibits ACH1, but ACH2 just at higher concentrations
Mg2+
-
50% inhibition at 1.6 mM
Mg2+
-
inhibits the microsomal enzyme, at higher concentrations also the mitochondrial enzyme
Mg2+
-
10 mM inhibits the enzyme by 30-35%
Mn2+
-
weakly inhibitory
Mn2+
-
0.2 mM gives 60% inhibition
Mn2+
-
inhibits ACH1, but ACH2 just at higher concentrations
Mn2+
-
almost complete inhibition at 10 mM
N-ethylmaleimide
-
0.001 mM gives 50% inhibition
NaCl
-
-
NaCl
-
inhibits at high concentrations
NADH
-
no inhibition
NADH
-
additive with oxidized CoA, noncompetitive
oleic acid
-
-
oleic acid
-
1 mM inhibits by 90%
p-chloromercuribenzoic acid
-
-
p-chloromercuribenzoic acid
-
p-chloromercuribenzoic acid
-
-
p-hydroxymercuribenzoate
-
99% inhibition at 0.1 mM
p-hydroxymercuribenzoate
-
weak inhibition
p-hydroxymercuribenzoate
-
0.005 mM gives 50% inhibition
p-hydroxymercuribenzoate
-
-
PMSF
-
96% inhibition at 1 mM
PMSF
-
less effective than DFP, produces a 27% loss of activity under similar conditions
SDS
-
-
SDS
-
50% inhibition at 0.035%
sodium deoxycholate
-
-
sodium deoxycholate
-
50% inhibition at 0.04%
Triton X-100
-
-
Triton X-100
-
0.05-.0025% inhibits the activity
Triton X-100
-
50% inhibition at 0.01%
Zn2+
-
-
additional information
no inhibition by iodoacetate
-
additional information
-
no inhibition by NEM
-
additional information
-
-
-
additional information
-
no inhibition by acetyl-CoA, diisopropyl fluorophosphate and bis(p-nitrophenyl)phosphate
-
additional information
-
no inhibition by NEM, iodoacetamide, L-carnitine
-
additional information
-
no inhibition by EDTA, Mg2+, Fe2+, NAD+, NADP+, NADPH, glutamate, 2-oxoglutarate, pyruvate, alanine, asparagine, succinate; no inhibition by NEM
-
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(tetradecylsulfanyl)acetic acid
-
stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview
1-acyl-sn-glycero-3-phosphocholine
-
0.5 mM stimulates acylation 3-9fold
3-(tetradecylsulfanyl)propanoic acid
-
stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview
3-hydroxybutyrate
-
stimulates the mitochondrial-matrix enzyme activity
3-thiadicarboxylic acid
-
-
ADP
-
stimulates the microsomal activity
di(2-ethylhexyl)phthalate
EDTA
-
stimulates the activity of the mitochondrial enzyme above 2 mM
Elongation factor
-
chain elongation
-
ethyl p-chlorophenoxyisobutyrate
-
-
FAD
-
stimulates the activity of the mitochondrial-matrix enzyme up to 0.4 mM
fish oil
-
partially hydrogenated, hydrolase activity reaches maximum after administration of the dietary oil for 6.5 days
-
FMN
-
stimulates the microsomal activity
fumarate
-
stimulates the microsomal activity
hexadecanol
-
activation, only with acyl-CoA of more than C-8 as substrates
isopropyl thiogalactoside
-
-
isopropyl-thio-beta-D-galactoside
-
inducer
isoproterenol
-
stimulates enzyme expression, can be blocked by specific beta-adrenoreceptor antagonists, e.g. actinomycin D
L-carnitine
-
activates at low concentrations
linoleic acid
-
both conjugated and gamma-linoleic acid, increase activity
lysophosphatidylcholine
-
-
lysophosphatidylethanolamine
-
-
malate
-
stimulates the mitochondrial-matrix enzyme activity
NAD+
-
stimulates the microsomal activity
oleate
induces enzyme expression in peroxisomes
Phenobarbital
-
2-3fold enhancement of activity
phosphatidylethanolamine
-
-
succinate
-
stimulates the mitochondrial-matrix enzyme activity
Tetradecanol
-
activation, only with acyl-CoA of more than C-8 as substrates
tetradecylthioacetic acid
-
-
ATP
-
-
ATP
-
stimulates the microsomal activity
bovine serum albumin
-
activation
-
bovine serum albumin
-
effect of stimulation increases as chain-length increases up to C-12 and decreases progressively as chain-length increases beyond C-12, inhibitory with octadecanoyl-CoA as substrate
-
bovine serum albumin
-
-
-
bovine serum albumin
-
-
-
bovine serum albumin
-
a small amount activates the hydrolase
-
bovine serum albumin
-
-
-
bovine serum albumin
-
activation
-
bovine serum albumin
-
only with long-chain acyl-CoA as substrate
-
Clofibrate
-
-
Clofibrate
-
peroxisome proliferator
Clofibrate
-
isozymes CTE-I and MTE-I are induced, induction is completely dependent on PPARalpha
Clofibrate
-
hypolipidemic drug
Clofibrate
-
2-3fold enhancement of activity
di(2-ethylhexyl)phthalate
-
peroxisome proliferator
di(2-ethylhexyl)phthalate
-
induction of enzyme expression
di(2-ethylhexyl)phthalate
-
-
di(2-ethylhexyl)phthalate
-
di(2-ethylhexyl)phthalate
-
-
di(2-ethylhexyl)phthalate
-
di(2-ethylhexyl)phthalate
-
stimulates
di(2-ethylhexyl)phthalate
strong induction in liver, moderately in kidney
di(2-ethylhexyl)phthalate
-
a plastisizer
di(2-ethylhexyl)phthalate
induction in liver, slightly in kidney
di(2-ethylhexyl)phthalate
-
induces the mitochondrial enzyme by 10fold
dithiothreitol
-
-
dithiothreitol
-
stimulation of the microsomal enzyme
monoethylhexylphthalate
-
-
monoethylhexylphthalate
-
-
monoethylhexylphthalate
-
-
nicotinic acid
-
-
nicotinic acid
-
stimulates the microsomal activity
PPARalpha
-
internal receptor protein essential for effect of stimulating compounds
-
PPARalpha
internal receptor protein essential for effect of stimulating compounds
-
PPARalpha
-
gene expression inducing and regulatory role, mediates the stimulation by clofibrate
-
PPARalpha
-
i.e. peroxisome proliferator-activated receptor alpha
-
PPARalpha
i.e. peroxisome proliferator-activated receptor alpha
-
tiadenol
-
-
tiadenol
-
produces a 7-9fold increase of the total activity
Triton X-100
-
slightly stimulates at low concentrations
Triton X-100
-
activation, 0.005%, dodecanoyl-CoA as substrate
Triton X-100
-
prevents inhibition together with serum albumin
Triton X-100
-
0.005% slightly stimulates the activity
additional information
movement of a helical lid controls access of substrates to the active site of RifR. The active site of RifR is a classic catalytic triad comprising residues Ser94, Asp200, and His228
-
additional information
-
movement of a helical lid controls access of substrates to the active site of RifR. The active site of RifR is a classic catalytic triad comprising residues Ser94, Asp200, and His228
-
additional information
-
EntH active site consists of Gln48, Gly55, Glu63, Thr64, Ser67, Met68, and Gly82
-
additional information
-
no stimulation of activity by docosahexaenoic and eisosapentaenoic acids
-
additional information
-
PA5185 contains Asp26
-
additional information
PA5185 contains Asp26
-
additional information
-
cold acclimation induces enzyme activity
-
additional information
-
no stimulation by tetradecylthiopropionate
-
additional information
-
overexpression of FscTE under the strong constitutive ermE*p promoter in the wild-type strain, does not suppress FR-008/candicidin formation
-
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acyl-coa hydrolase deficiency
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
Adenocarcinoma of Lung
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Adenocarcinoma of Lung
Overexpression and proliferation dependence of acyl-CoA thioesterase 11 and 13 in lung adenocarcinoma.
Carcinoma
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Carcinoma, Squamous Cell
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Colonic Neoplasms
Exosomal miR-183-5p Shuttled by M2 Polarized Tumor-Associated Macrophage Promotes the Development of Colon Cancer via Targeting THEM4 Mediated PI3K/AKT and NF-?B Pathways.
Dyslexia
Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with Developmental Dyslexia.
Dyslexia
The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration.
Dyslipidemias
Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids into Triglyceride Biosynthesis.
Fatty Liver
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development.
Fatty Liver
Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis.
Fatty Liver
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Infections
Weighted gene co-expression network analysis and drug-gene interaction bioinformatics uncover key genes associated with various presentations of malaria infection in African children and major drug candidates.
Insulin Resistance
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
Insulin Resistance
Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis.
Insulin Resistance
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Liver Diseases
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Lung Neoplasms
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Neoplasms
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Neoplasms
Comprehensive genome methylation analysis in bladder cancer;identification and validation of novel methylated genes and application of these as urinary tumor markers.
Non-alcoholic Fatty Liver Disease
Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids into Triglyceride Biosynthesis.
Non-alcoholic Fatty Liver Disease
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Obesity
New players on the metabolic stage: How do you like Them Acots?
Obesity
Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue.
Obesity
Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids into Triglyceride Biosynthesis.
Obesity
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Overnutrition
Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress.
Tuberculosis
Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.
Tuberculosis
Insights into the Substrate Specificity of a Thioesterase Rv0098 of Mycobacterium Tuberculosis through X-ray Crystallographic and Molecular Dynamics Studies.
Tuberculosis
Structure based drug discovery for designing leads for the non-toxic metabolic targets in multi drug resistant Mycobacterium tuberculosis.
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0.0375 - 1.42
2,3-dihydroxybenzoyl-CoA
0.116
2,3-dihydroxybenzoyl-EntB
-
wild-type, at room temperature
-
0.219
2,4-dihydroxybenzoyl-CoA
-
wild-type, at room temperature
0.0682 - 0.22
2-butenoyl-CoA
0.212
3,4-dihydroxybenzoyl-CoA
-
wild-type, at room temperature
0.01
3,4-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.0108
3,5-cis-dodecadienoyl-CoA
-
0.003
3,5-cis-tetradecadienoyl-CoA
-
0.256
3,5-dihydroxybenzoyl-CoA
-
wild-type, at room temperature
0.025
3,5-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.3057 - 2.9
3-hydroxy-3-methylglutaryl-CoA
0.032 - 0.265
3-hydroxybenzoyl-CoA
0.1628
3-hydroxybutyryl-CoA
-
-
0.0037 - 0.9
3-hydroxyphenylacetyl-CoA
0.0058
3-hydroxytetradecanoyl-CoA
-
0.13
4-chlorobenzoyl-CoA
wild-type protein, pH7.5, 25°C
0.025 - 0.19
4-hydroxybenzoyl-CoA
0.0076 - 0.049
4-hydroxyphenylacetyl-CoA
0.019
8-methylnonanoyl-CoA
-
pH 8.0
0.037 - 0.048
acetoacetyl-CoA
33.4
acetyl-S-N-acetylcysteamine
-
at pH 7.4, 30°C
0.0004 - 0.02
Arachidonoyl-CoA
0.0042 - 0.039
arachidoyl-CoA
0.216 - 0.475
benzoyl-CoA
0.11
beta-hydroxybutyryl-CoA
wild-type protein, pH7.5, 25°C
0.009 - 0.29
beta-methylcrotonyl-CoA
0.0352
butanoyl-CoA
-
pH 8.0
0.67
cezomycin-CoA
-
at pH 7.5 and 30°C
0.00284 - 0.00551
cis-vaccenoyl-CoA
0.0059 - 0.18
crotonyl-CoA
0.0027 - 0.067
decanoyl-CoA
0.02 - 0.0868
DL-3-hydroxy-3-methylglutaryl-CoA
0.031 - 0.0479
DL-3-hydroxybutyryl-CoA
0.0018 - 0.325
dodecanoyl-CoA
0.0004
eicosanoyl-CoA
-
-
0.00013 - 0.006
fatty-acyl-CoA thioester
0.0081 - 0.67
glutaryl-CoA
0.0000158 - 0.08
hexadecanoyl-CoA
0.0055 - 0.1382
hexanoyl-CoA
0.013 - 0.092
isobutyryl-CoA
0.014
isovaleryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.00348 - 0.0275
lauroyl-CoA
0.00786 - 0.0154
linolenoyl-CoA
0.0014 - 0.31
linoleoyl-CoA
0.0232 - 0.28
malonyl-CoA
0.17 - 0.21
methylmalonyl-CoA
0.00339 - 0.0046
myristoleoyl-CoA
0.0025 - 0.0228
myristoyl-CoA
34
N-acetylcysteamine acetate
-
at pH 7.5, 30°C
56
N-acetylcysteamine butyrate
-
at pH 7.5, 30°C
52
N-acetylcysteamine propionate
-
at pH 7.5, 30°C
0.0035 - 0.6
n-butyryl-CoA
0.8 - 1.4
n-butyryl-pantetheine phosphate
0.0045 - 0.048
n-decanoyl-CoA
0.0041 - 0.07
n-hexanoyl-CoA
0.0019 - 0.026
n-octanoyl-CoA
0.19
n-propionyl-CoA
wild-type protein, pH7.5, 25°C
0.0218
nonanoyl-CoA
-
pH 8.0
0.0004 - 0.034
octadecanoyl-CoA
0.007 - 0.118
octanoyl-CoA
0.0014 - 0.0274
oleoyl-CoA
0.0014 - 0.058
palmitoleoyl-CoA
0.0024 - 33
palmitoyl-CoA
0.0016 - 0.24
phenylacetyl-CoA
0.006
propionyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
32
propionyl-S-n-acetylcysteamine
-
at pH 7.4, 30°C
0.162 - 0.729
salicylyl-CoA
0.272
salicylyl-EntB
-
wild-type, at room temperature
-
0.0015 - 0.0279
stearoyl-CoA
0.014 - 0.048
succinyl-CoA
0.0017 - 0.024
tetradecanoyl-CoA
0.00084 - 0.0029
vaccenoyl-CoA
additional information
additional information
-
0.0375
2,3-dihydroxybenzoyl-CoA
-
mutant H54A, at room temperature
0.161
2,3-dihydroxybenzoyl-CoA
-
wild-type, at room temperature
0.329
2,3-dihydroxybenzoyl-CoA
-
mutant S67A, at room temperature
0.383
2,3-dihydroxybenzoyl-CoA
-
mutant T64S, at room temperature
0.454
2,3-dihydroxybenzoyl-CoA
-
mutant S67C, at room temperature
0.505
2,3-dihydroxybenzoyl-CoA
-
mutant Q48N, at room temperature
1.42
2,3-dihydroxybenzoyl-CoA
-
mutant M68A, at room temperature
0.0682
2-butenoyl-CoA
-
pH 7.5, 37°C
0.22
2-butenoyl-CoA
wild-type protein, pH7.5, 25°C
0.3057
3-hydroxy-3-methylglutaryl-CoA
-
-
2.9
3-hydroxy-3-methylglutaryl-CoA
wild-type protein, pH7.5, 25°C
0.032
3-hydroxybenzoyl-CoA
wild-type protein, pH7.5, 25°C
0.265
3-hydroxybenzoyl-CoA
-
wild-type, at room temperature
0.0037
3-hydroxyphenylacetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.026
3-hydroxyphenylacetyl-CoA
H56A mutant protein, pH7.5, 25°C
0.12
3-hydroxyphenylacetyl-CoA
K136A mutant protein, pH7.5, 25°C
0.16
3-hydroxyphenylacetyl-CoA
T69A mutant protein, pH7.5, 25°C
0.23
3-hydroxyphenylacetyl-CoA
D65E mutant protein, pH7.5, 25°C
0.3
3-hydroxyphenylacetyl-CoA
N50A mutant protein, pH7.5, 25°C
0.31
3-hydroxyphenylacetyl-CoA
S83A mutant protein, pH7.5, 25°C
0.36
3-hydroxyphenylacetyl-CoA
D65N mutant protein, pH7.5, 25°C
0.41
3-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.62
3-hydroxyphenylacetyl-CoA
H134A mutant protein, pH7.5, 25°C
0.9
3-hydroxyphenylacetyl-CoA
H137A mutant protein, pH7.5, 25°C
0.025
4-hydroxybenzoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.19
4-hydroxybenzoyl-CoA
-
wild-type, at room temperature
0.0076
4-hydroxyphenylacetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.049
4-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.037
acetoacetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.048
acetoacetyl-CoA
-
-
0.0047
acetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0481
acetyl-CoA
-
pH 7.5, 37°C
0.0764
acetyl-CoA
-
pH 8.0
0.167
acetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.2
acetyl-CoA
-
at pH 7.5 and 30°C
0.29
acetyl-CoA
wild-type protein, pH7.5, 25°C
0.0004
Arachidonoyl-CoA
-
-
0.002
Arachidonoyl-CoA
-
isozyme MTE-I, pH 7.4, 37°C
0.0041
Arachidonoyl-CoA
-
isozyme CTE-I, pH 7.4, 37°C
0.0046
Arachidonoyl-CoA
-
pH 7.5, 37°C
0.0067
Arachidonoyl-CoA
pH 7.4
0.0092
Arachidonoyl-CoA
pH 7.4, 30°C
0.0133
Arachidonoyl-CoA
-
pH 7.5, 37°C
0.019
Arachidonoyl-CoA
pH 7.5, 37°C, wild-type
0.02
Arachidonoyl-CoA
wild-type protein, pH7.5, 25°C
0.0042
arachidoyl-CoA
pH 7.4
0.039
arachidoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.216
benzoyl-CoA
-
at pH 7.5 and 30°C
0.475
benzoyl-CoA
-
wild-type, at room temperature
0.009
beta-methylcrotonyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.12
beta-methylcrotonyl-CoA
wild-type protein, pH7.5, 25°C
0.29
beta-methylcrotonyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.013
butyryl-CoA
-
pH 7.8, 22°C
0.19
butyryl-CoA
-
at pH 7.5 and 30°C
0.00284
cis-vaccenoyl-CoA
-
37°C, pH 7.6
0.00551
cis-vaccenoyl-CoA
-
20°C, pH 7.6
0.077
CoA
-
-
0.0059
crotonyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.18
crotonyl-CoA
wild-type protein, pH7.5, 25°C
0.0027
decanoyl-CoA
-
pH 7.8, 22°C
0.027
decanoyl-CoA
-
pH 7.0, 30°C
0.0271
decanoyl-CoA
-
pH 8.0
0.067
decanoyl-CoA
-
pH 7.4, 25°C
0.02
DL-3-hydroxy-3-methylglutaryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0868
DL-3-hydroxy-3-methylglutaryl-CoA
-
pH 7.5, 37°C
0.031
DL-3-hydroxybutyryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0479
DL-3-hydroxybutyryl-CoA
-
pH 7.5, 37°C
0.0018
dodecanoyl-CoA
-
pH 7.8, 22°C
0.0038
dodecanoyl-CoA
-
pH 7.5, 37°C
0.0076
dodecanoyl-CoA
pH 7.4, 30°C
0.0077
dodecanoyl-CoA
-
-
0.0104
dodecanoyl-CoA
-
pH 8.0
0.014
dodecanoyl-CoA
-
pH 7.0, 30°C
0.018
dodecanoyl-CoA
-
pH 8.0
0.04468
dodecanoyl-CoA
-
-
0.00013 - 0.006
fatty-acyl-CoA thioester
-
-
0.00013 - 0.006
fatty-acyl-CoA thioester
-
-
0.00013 - 0.006
fatty-acyl-CoA thioester
-
-
0.0081
glutaryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.67
glutaryl-CoA
wild-type protein, pH7.5, 25°C
0.0000158
hexadecanoyl-CoA
-
-
0.0001
hexadecanoyl-CoA
-
-
0.0005
hexadecanoyl-CoA
-
pH 7.8, 22°C
0.0008
hexadecanoyl-CoA
-
-
0.0014
hexadecanoyl-CoA
-
-
0.0017
hexadecanoyl-CoA
pH 7.4
0.00186
hexadecanoyl-CoA
-
-
0.002
hexadecanoyl-CoA
-
-
0.005
hexadecanoyl-CoA
-
micellar
0.0057
hexadecanoyl-CoA
-
-
0.0058
hexadecanoyl-CoA
-
pH 7.5, 37°C
0.0062
hexadecanoyl-CoA
-
-
0.0064
hexadecanoyl-CoA
pH 7.4, 30°C
0.008
hexadecanoyl-CoA
-
-
0.009
hexadecanoyl-CoA
-
-
0.01
hexadecanoyl-CoA
recombinant enzyme
0.012
hexadecanoyl-CoA
-
-
0.015
hexadecanoyl-CoA
-
-
0.017
hexadecanoyl-CoA
-
-
0.017
hexadecanoyl-CoA
-
pH 7.0, 30°C
0.023
hexadecanoyl-CoA
-
pH 7.4, 25°C
0.045
hexadecanoyl-CoA
-
the induced E. coli enzyme
0.047
hexadecanoyl-CoA
-
-
0.047
hexadecanoyl-CoA
-
for the microsomal enzyme
0.06
hexadecanoyl-CoA
-
brain ACT
0.07 - 0.08
hexadecanoyl-CoA
-
-
0.0055
hexanoyl-CoA
-
pH 7.8, 22°C
0.077
hexanoyl-CoA
-
pH 7.0, 30°C
0.013
isobutyryl-CoA
wild-type protein
0.013
isobutyryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.015
isobutyryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.092
isobutyryl-CoA
N29A mutant protein
0.00348
lauroyl-CoA
-
37°C, pH 7.6
0.0042
lauroyl-CoA
N29A mutant protein
0.006
lauroyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0066
lauroyl-CoA
wild-type protein
0.0079
lauroyl-CoA
-
pH 7.5, 37°C
0.0099
lauroyl-CoA
wild-type protein, pH7.5, 25°C
0.02
lauroyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.00786
linolenoyl-CoA
-
-
0.0154
linolenoyl-CoA
pH 7.5, 37°C, wild-type
0.0014
linoleoyl-CoA
-
-
0.0023
linoleoyl-CoA
pH 7.4
0.0042
linoleoyl-CoA
pH 7.5, 37°C, wild-type
0.0042
linoleoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0093
linoleoyl-CoA
-
pH 7.5, 37°C
0.31
linoleoyl-CoA
wild-type protein, pH7.5, 25°C
0.0232
malonyl-CoA
-
pH 7.5, 37°C
0.14
malonyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.188
malonyl-CoA
-
at pH 7.5 and 30°C
0.28
malonyl-CoA
wild-type protein, pH7.5, 25°C
0.17
methylmalonyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.21
methylmalonyl-CoA
wild-type protein, pH7.5, 25°C
0.00339
myristoleoyl-CoA
-
37°C, pH 7.6
0.0046
myristoleoyl-CoA
-
-
0.0025
myristoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.00266
myristoyl-CoA
-
37°C, pH 7.6
0.005
myristoyl-CoA
wild-type protein, pH7.5, 25°C
0.0073
myristoyl-CoA
-
at 25°C
0.0081
myristoyl-CoA
-
pH 7.5, 37°C
0.0086
myristoyl-CoA
pH 7.5, 37°C, wild-type
0.009
myristoyl-CoA
wild-type protein, pH7.5, 37°C
0.0106
myristoyl-CoA
-
at 37°C, in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 0.5
0.0136
myristoyl-CoA
-
at 37°C, in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 1.0
0.0155
myristoyl-CoA
-
at 37°C
0.0214
myristoyl-CoA
-
at 50°C
0.0228
myristoyl-CoA
-
at 37°C, in the presence of small unilamellar vesicles composed of phosphatidylcholine at 4 mM total phospholipid concentration
0.0035
n-butyryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.068
n-butyryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.6
n-butyryl-CoA
wild-type protein, pH7.5, 25°C
0.8
n-butyryl-pantetheine phosphate
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
1.4
n-butyryl-pantetheine phosphate
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0045
n-decanoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0049
n-decanoyl-CoA
wild-type protein, pH7.5, 25°C
0.013
n-decanoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0041
n-hexanoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.07
n-hexanoyl-CoA
wild-type protein, pH7.5, 25°C
0.0019
n-octanoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.026
n-octanoyl-CoA
wild-type protein, pH7.5, 25°C
0.0004
octadecanoyl-CoA
-
pH 7.8, 22°C
0.024
octadecanoyl-CoA
-
pH 7.4, 25°C
0.034
octadecanoyl-CoA
-
pH 7.0, 30°C
0.007
octanoyl-CoA
-
pH 7.8, 22°C
0.014
octanoyl-CoA
pH 7.4, 30°C
0.0175
octanoyl-CoA
-
pH 8.0
0.043
octanoyl-CoA
-
pH 7.0, 30°C
0.118
octanoyl-CoA
-
pH 7.4, 25°C
0.0014
oleoyl-CoA
-
-
0.0059
oleoyl-CoA
-
pH 8.0
0.0088
oleoyl-CoA
pH 7.4, 30°C
0.009
oleoyl-CoA
wild-type protein, pH7.5, 25°C
0.011
oleoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.011
oleoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0128
oleoyl-CoA
-
pH 7.5, 37°C
0.0014
palmitoleoyl-CoA
pH 7.4
0.0039
palmitoleoyl-CoA
-
37°C, pH 7.6
0.0058
palmitoleoyl-CoA
-
pH 8.0
0.0064
palmitoleoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0072
palmitoleoyl-CoA
-
20°C, pH 7.6
0.009
palmitoleoyl-CoA
wild-type protein, pH7.5, 25°C
0.0136
palmitoleoyl-CoA
-
pH 7.5, 37°C
0.026
palmitoleoyl-CoA
pH 7.5, 37°C, wild-type
0.058
palmitoleoyl-CoA
-
pH 7.4, 25°C
0.0024
palmitoyl-CoA
pH 7.5, 37°C, wild-type
0.00385
palmitoyl-CoA
-
20°C, pH 7.6
0.00411
palmitoyl-CoA
-
37°C, pH 7.6
0.00425
palmitoyl-CoA
-
wild-type, at room temperature
0.0075
palmitoyl-CoA
-
pH 7.5, 37°C
0.0159
palmitoyl-CoA
-
in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 1.0
0.016
palmitoyl-CoA
wild-type protein, pH7.5, 25°C
0.017
palmitoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.018
palmitoyl-CoA
-
in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 0.5
0.141
palmitoyl-CoA
-
at pH 7.5 and 30°C
33
palmitoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0016
phenylacetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.016
phenylacetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0498
phenylacetyl-CoA
-
pH 7.5, 37°C
0.1916
phenylacetyl-CoA
-
-
0.24
phenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.162
salicylyl-CoA
-
mutant H54A, at room temperature
0.176
salicylyl-CoA
-
wild-type, at room temperature
0.196
salicylyl-CoA
-
mutant S67C, at room temperature
0.263
salicylyl-CoA
-
mutant S67A, at room temperature
0.373
salicylyl-CoA
-
mutant M68A, at room temperature
0.672
salicylyl-CoA
-
mutant T64S, at room temperature
0.729
salicylyl-CoA
-
mutant Q48N, at room temperature
0.0015
stearoyl-CoA
-
pH 8, temperature not specified in the publication
0.00359
stearoyl-CoA
-
37°C, pH 7.6
0.0042
stearoyl-CoA
pH 7.5, 37°C, wild-type
0.01
stearoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.02
stearoyl-CoA
wild-type protein, pH7.5, 25°C
0.0279
stearoyl-CoA
-
pH 7.5, 37°C
0.014
succinyl-CoA
-
0.02
succinyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0017
tetradecanoyl-CoA
-
pH 7.8, 22°C
0.0025
tetradecanoyl-CoA
pH 7.4
0.0066
tetradecanoyl-CoA
-
-
0.00867
tetradecanoyl-CoA
-
-
0.018
tetradecanoyl-CoA
-
pH 7.4, 25°C
0.024
tetradecanoyl-CoA
-
pH 7.0, 30°C
0.0021
tiglyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.25
tiglyl-CoA
wild-type protein, pH7.5, 25°C
0.00084
vaccenoyl-CoA
-
-
0.0029
vaccenoyl-CoA
pH 7.5, 37°C, wild-type
additional information
additional information
-
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
effect of pH on kinetic data
-
additional information
additional information
-
Km at different temperatures
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00217 - 0.533
2,3-dihydroxybenzoyl-CoA
0.14
2,3-dihydroxybenzoyl-EntB
-
wild-type, at room temperature
-
0.0342
2,4-dihydroxybenzoyl-CoA
-
wild-type, at room temperature
0.014 - 11
2-butenoyl-CoA
0.23
3,4-dihydroxybenzoyl-CoA
-
wild-type, at room temperature
0.19
3,4-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
21.6
3,5-cis-dodecadienoyl-CoA
-
2 - 3.7
3,5-cis-tetradecadienoyl-CoA
-
7.45
3,5-dihydroxybenzoyl-CoA
-
wild-type, at room temperature
0.19
3,5-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.007 - 0.079
3-hydroxy-3-methylglutaryl-CoA
0.011 - 10.3
3-hydroxybenzoyl-CoA
0.046
3-hydroxybutyryl-CoA
-
-
0.007 - 140
3-hydroxyphenylacetyl-CoA
10.7
3-hydroxytetradecanoyl-CoA
-
0.0032
4-chlorobenzoyl-CoA
wild-type protein, pH7.5, 25°C
0.0062 - 0.207
4-hydroxybenzoyl-CoA
0.14 - 75
4-hydroxyphenylacetyl-CoA
35
acetoacetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
1.193
acetyl-S-N-acetylcysteamine
-
at pH 7.4, 30°C
0.022 - 1.4
Arachidonoyl-CoA
0.27
arachidoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.18
beta-hydroxybutyryl-CoA
wild-type protein, pH7.5, 25°C
0.023 - 0.54
beta-methylcrotonyl-CoA
0.08
butyrylpantetheine phosphate
wild-type protein
0.3
cezomycin-CoA
-
at pH 7.5 and 30°C
0.0076 - 0.92
crotonyl-CoA
8.9 - 12
DL-3-hydroxy-3-methylglutaryl-CoA
8.3 - 13
DL-3-hydroxybutyryl-CoA
2.34 - 140
isobutyryl-CoA
30
isovaleryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
13.3
linolenoyl-CoA
pH 7.5, 37°C, wild-type
0.017 - 12.2
linoleoyl-CoA
0.083 - 1.1
methylmalonyl-CoA
7.5
N-acetylcysteamine acetate
-
at pH 7.5, 30°C
1.817
N-acetylcysteamine butyrate
-
at pH 7.5, 30°C
0.9
N-acetylcysteamine propionate
-
at pH 7.5, 30°C
0.082
n-butyryl-pantetheine phosphate
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.8
n-butyrylpantethiene phosphate
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.016 - 17
n-decanoyl-CoA
0.022
n-hexanoyl-CoA
wild-type protein, pH7.5, 25°C
0.0047 - 4.6
n-octanoyl-CoA
0.036
n-propionyl-CoA
wild-type protein, pH7.5, 25°C
159
octanoyl-CoA
-
pH 7.4, 25°C
0.017 - 106
palmitoleoyl-CoA
0.0009 - 153
palmitoyl-CoA
0.084 - 130
phenylacetyl-CoA
25
propionyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
1.82
propionyl-S-n-acetylcysteamine
-
at pH 7.4, 30°C
0.019 - 4.63
salicylyl-CoA
4.83
salicylyl-EntB
-
wild-type, at room temperature
-
190
succinyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
1.8
vaccenoyl-CoA
pH 7.5, 37°C, wild-type
additional information
additional information
-
0.00217
2,3-dihydroxybenzoyl-CoA
-
mutant H54A, at room temperature
0.00333
2,3-dihydroxybenzoyl-CoA
-
mutant S67C, at room temperature
0.0112
2,3-dihydroxybenzoyl-CoA
-
mutant S67A, at room temperature
0.0155
2,3-dihydroxybenzoyl-CoA
-
mutant Q48N, at room temperature
0.138
2,3-dihydroxybenzoyl-CoA
-
mutant T64S, at room temperature
0.372
2,3-dihydroxybenzoyl-CoA
-
wild-type, at room temperature
0.533
2,3-dihydroxybenzoyl-CoA
-
mutant M68A, at room temperature
0.014
2-butenoyl-CoA
wild-type protein, pH7.5, 25°C
11
2-butenoyl-CoA
-
pH 7.5, 37°C
0.007
3-hydroxy-3-methylglutaryl-CoA
-
-
0.079
3-hydroxy-3-methylglutaryl-CoA
wild-type protein, pH7.5, 25°C
0.011
3-hydroxybenzoyl-CoA
wild-type protein, pH7.5, 25°C
10.3
3-hydroxybenzoyl-CoA
-
wild-type, at room temperature
0.007
3-hydroxyphenylacetyl-CoA
N50A mutant protein, pH7.5, 25°C
0.15
3-hydroxyphenylacetyl-CoA
S83A mutant protein, pH7.5, 25°C
0.16
3-hydroxyphenylacetyl-CoA
D65E mutant protein, pH7.5, 25°C
0.16
3-hydroxyphenylacetyl-CoA
H134A mutant protein, pH7.5, 25°C
0.32
3-hydroxyphenylacetyl-CoA
K136A mutant protein, pH7.5, 25°C
0.36
3-hydroxyphenylacetyl-CoA
D65N mutant protein, pH7.5, 25°C
0.62
3-hydroxyphenylacetyl-CoA
H56A mutant protein, pH7.5, 25°C
0.66
3-hydroxyphenylacetyl-CoA
T69A mutant protein, pH7.5, 25°C
0.83
3-hydroxyphenylacetyl-CoA
H137A mutant protein, pH7.5, 25°C
1.4
3-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
140
3-hydroxyphenylacetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0062
4-hydroxybenzoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.078
4-hydroxybenzoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.207
4-hydroxybenzoyl-CoA
-
wild-type, at room temperature
0.14
4-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
75
4-hydroxyphenylacetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.021
acetyl-CoA
-
at pH 7.5 and 30°C
0.054
acetyl-CoA
wild-type protein, pH7.5, 25°C
0.55
acetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
1.3
acetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
24
acetyl-CoA
-
pH 7.5, 37°C
0.022
Arachidonoyl-CoA
wild-type protein, pH7.5, 25°C
1.2
Arachidonoyl-CoA
-
pH 7.5, 37°C
1.4
Arachidonoyl-CoA
pH 7.5, 37°C, wild-type
0.015
benzoyl-CoA
-
at pH 7.5 and 30°C
13.9
benzoyl-CoA
-
wild-type, at room temperature
0.023
beta-methylcrotonyl-CoA
wild-type protein, pH7.5, 25°C
0.1
beta-methylcrotonyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.54
beta-methylcrotonyl-CoA
absorbance of 5-thio-2-nitrobenzoate formed by reaction of 5,5'-dithiobis(2-nitrobenzoic acid) is measured
0.021
butyryl-CoA
-
at pH 7.5 and 30°C
6.7
butyryl-CoA
wild-type protein
0.0076
crotonyl-CoA
wild-type protein, pH7.5, 25°C
0.92
crotonyl-CoA
absorbance of 5-thio-2-nitrobenzoate formed by reaction of 5,5'-dithiobis(2-nitrobenzoic acid) is measured
0.055
decanoyl-CoA
-
-
136
decanoyl-CoA
-
pH 7.4, 25°C
8.9
DL-3-hydroxy-3-methylglutaryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
12
DL-3-hydroxy-3-methylglutaryl-CoA
-
pH 7.5, 37°C
8.3
DL-3-hydroxybutyryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
13
DL-3-hydroxybutyryl-CoA
-
pH 7.5, 37°C
0.05
glutaryl-CoA
wild-type protein, pH7.5, 25°C
100
glutaryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.03
hexanoyl-CoA
-
-
15
hexanoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
2.34
isobutyryl-CoA
N29A mutant protein
9.5
isobutyryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
138
isobutyryl-CoA
wild-type protein
140
isobutyryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.019
lauroyl-CoA
wild-type protein, pH7.5, 25°C
2.57
lauroyl-CoA
N29A mutant protein
5.3
lauroyl-CoA
-
pH 7.5, 37°C
9.2
lauroyl-CoA
wild-type protein
9.2
lauroyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
9.6
lauroyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.017
linoleoyl-CoA
wild-type protein, pH7.5, 25°C
0.8
linoleoyl-CoA
pH 7.5, 37°C, mutant D167A
2
linoleoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
2.7
linoleoyl-CoA
-
pH 7.5, 37°C
12.2
linoleoyl-CoA
pH 7.5, 37°C, wild-type
0.014
malonyl-CoA
-
-
0.017
malonyl-CoA
-
at pH 7.5 and 30°C
0.066
malonyl-CoA
wild-type protein, pH7.5, 25°C
3.3
malonyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
9.6
malonyl-CoA
-
pH 7.5, 37°C
0.083
methylmalonyl-CoA
wild-type protein, pH7.5, 25°C
1.1
methylmalonyl-CoA
absorbance of 5-thio-2-nitrobenzoate formed by reaction of 5,5'-dithiobis(2-nitrobenzoic acid) is measured
0.02
myristoyl-CoA
wild-type protein, pH7.5, 25°C
0.031
myristoyl-CoA
-
at 25°C
0.033
myristoyl-CoA
-
at 37°C, in the presence of small unilamellar vesicles composed of phosphatidylcholine at 4 mM total phospholipid concentration
0.047
myristoyl-CoA
-
at 37°C
0.062
myristoyl-CoA
-
at 50°C
0.069
myristoyl-CoA
-
at 37°C, in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 0.5
0.07
myristoyl-CoA
wild-type protein, pH7.5, 37°C
0.086
myristoyl-CoA
-
at 37°C, in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 1.0
4.7
myristoyl-CoA
-
pH 7.5, 37°C
6.9
myristoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
19.7
myristoyl-CoA
pH 7.5, 37°C, wild-type
183
myristoyl-CoA
-
pH 7.4, 25°C
0.047
n-butyryl-CoA
wild-type protein, pH7.5, 25°C
6.7
n-butyryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
22
n-butyryl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.016
n-decanoyl-CoA
wild-type protein, pH7.5, 25°C
13
n-decanoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
17
n-decanoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.0047
n-octanoyl-CoA
wild-type protein, pH7.5, 25°C
4.6
n-octanoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.011
oleoyl-CoA
wild-type protein, pH7.5, 25°C
1.7
oleoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
3.2
oleoyl-CoA
-
pH 7.5, 37°C
13
oleoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.017
palmitoleoyl-CoA
wild-type protein, pH7.5, 25°C
4.7
palmitoleoyl-CoA
-
pH 7.5, 37°C
5.7
palmitoleoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
11.5
palmitoleoyl-CoA
pH 7.5, 37°C, wild-type
106
palmitoleoyl-CoA
-
pH 7.4, 25°C
0.0009
palmitoyl-CoA
-
at pH 7.5 and 30°C
0.0044
palmitoyl-CoA
wild-type protein, pH7.5, 25°C
0.0066
palmitoyl-CoA
-
in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 1.0
0.057
palmitoyl-CoA
-
in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 0.5
0.154
palmitoyl-CoA
-
wild-type, at room temperature
0.5
palmitoyl-CoA
pH 7.5, 37°C, mutant D167A
2.7
palmitoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
3.7
palmitoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
8.5
palmitoyl-CoA
-
pH 7.5, 37°C
16.6
palmitoyl-CoA
pH 7.5, 37°C, wild-type
153
palmitoyl-CoA
-
pH 7.4, 25°C
0.084
phenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.12
phenylacetyl-CoA
-
-
3.2
phenylacetyl-CoA
-
pH 7.5, 37°C
9.4
phenylacetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
130
phenylacetyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
0.019
salicylyl-CoA
-
mutant H54A, at room temperature
0.0507
salicylyl-CoA
-
mutant S67A, at room temperature
0.051
salicylyl-CoA
-
mutant S67C, at room temperature
0.0678
salicylyl-CoA
-
mutant Q48N, at room temperature
0.0778
salicylyl-CoA
-
mutant M68A, at room temperature
1.38
salicylyl-CoA
-
mutant T64S, at room temperature
4.63
salicylyl-CoA
-
wild-type, at room temperature
0.011
stearoyl-CoA
wild-type protein, pH7.5, 25°C
0.2
stearoyl-CoA
pH 7.5, 37°C, mutant D167A
0.77
stearoyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
1.2
stearoyl-CoA
pH 7.5, 37°C, wild-type
2.3
stearoyl-CoA
-
pH 7.5, 37°C
5.7
stearoyl-CoA
-
pH 8, temperature not specified in the publication
121
stearoyl-CoA
-
pH 7.4, 25°C
0.02
tiglyl-CoA
wild-type protein, pH7.5, 25°C
2.6
tiglyl-CoA
pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay
additional information
additional information
D44A mutant protein: value below 0.001 s-1 for isobutyryl-CoA and lauroyl-CoA
-
additional information
additional information
-
D44A mutant protein: value below 0.001 s-1 for isobutyryl-CoA and lauroyl-CoA
-
additional information
additional information
-
inactive with acetyl-CoA and 2-butenoyl-CoA
-
additional information
additional information
inactive with substrates having acyl chains with fewer than 12 carbon atoms
-
additional information
additional information
-
inactive with substrates having acyl chains with fewer than 12 carbon atoms
-
additional information
additional information
no activity observed with 4-hydroxybenzoyl-CoA, lauroyl-acyl carrier protein, myristoyl-acyl carrier protein, palmitoyl-acyl carrier protein, octanoyl-acyl carrier protein, oleoyl-acyl carrier protein and acylated peptide N-acetyl-Gly-Ala-Cys-S-palmitoyl, turnover number of mutant protein D65A below 0.00001 s-1 for 3-hydroxyphenylacetyl-CoA
-
additional information
additional information
-
no activity observed with 4-hydroxybenzoyl-CoA, lauroyl-acyl carrier protein, myristoyl-acyl carrier protein, palmitoyl-acyl carrier protein, octanoyl-acyl carrier protein, oleoyl-acyl carrier protein and acylated peptide N-acetyl-Gly-Ala-Cys-S-palmitoyl, turnover number of mutant protein D65A below 0.00001 s-1 for 3-hydroxyphenylacetyl-CoA
-
additional information
propionyl-S-n-acetylcysteamine
absorbance of 5-thio-2-nitrobenzoate formed by reaction of 5,5'-dithiobis(2-nitrobenzoic acid) is measured, Kcat is above 0.0001
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0.064
2-butenoyl-CoA
wild-type protein, pH7.5, 25°C
18
3,4-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
2000
3,5-cis-dodecadienoyl-CoA
-
7900
3,5-cis-tetradecadienoyl-CoA
-
7.9
3,5-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.023 - 0.027
3-hydroxy-3-methylglutaryl-CoA
0.35
3-hydroxybenzoyl-CoA
wild-type protein, pH7.5, 25°C
0.28
3-hydroxybutyryl-CoA
-
-
0.023 - 35
3-hydroxyphenylacetyl-CoA
1800
3-hydroxytetradecanoyl-CoA
-
0.025
4-chlorobenzoyl-CoA
wild-type protein, pH7.5, 25°C
2.9
4-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
1.1 - 73
Arachidonoyl-CoA
0.071
benzoyl-CoA
-
at pH 7.5 and 30°C
1.6
beta-hydroxybutyryl-CoA
wild-type protein, pH7.5, 25°C
0.19
beta-methylcrotonyl-CoA
wild-type protein, pH7.5, 25°C
0.1
butyrylpantetheine phosphate
wild-type protein
0.442
cezomycin-CoA
-
at pH 7.5 and 30°C
0.47
crotonyl-CoA
wild-type protein, pH7.5, 25°C
0.75
glutaryl-CoA
wild-type protein, pH7.5, 25°C
25 - 11000
isobutyryl-CoA
860
linolenoyl-CoA
pH 7.5, 37°C, wild-type
0.054 - 2900
linoleoyl-CoA
0.39
methylmalonyl-CoA
wild-type protein, pH7.5, 25°C
0.078
n-butyryl-CoA
wild-type protein, pH7.5, 25°C
3.3
n-decanoyl-CoA
wild-type protein, pH7.5, 25°C
0.31
n-hexanoyl-CoA
wild-type protein, pH7.5, 25°C
0.18
n-octanoyl-CoA
wild-type protein, pH7.5, 25°C
0.19
n-propionyl-CoA
wild-type protein, pH7.5, 25°C
1.9 - 430
palmitoleoyl-CoA
0.0062 - 6900
palmitoyl-CoA
0.35 - 0.63
phenylacetyl-CoA
0.082
tiglyl-CoA
wild-type protein, pH7.5, 25°C
540
vaccenoyl-CoA
pH 7.5, 37°C, wild-type
0.023
3-hydroxy-3-methylglutaryl-CoA
-
-
0.027
3-hydroxy-3-methylglutaryl-CoA
wild-type protein, pH7.5, 25°C
0.023
3-hydroxyphenylacetyl-CoA
N50A mutant protein, pH7.5, 25°C
0.17
3-hydroxyphenylacetyl-CoA
H134A mutant protein, pH7.5, 25°C
0.58
3-hydroxyphenylacetyl-CoA
S83A mutant protein, pH7.5, 25°C
0.67
3-hydroxyphenylacetyl-CoA
D65E mutant protein, pH7.5, 25°C
0.92
3-hydroxyphenylacetyl-CoA
H137A mutant protein, pH7.5, 25°C
1
3-hydroxyphenylacetyl-CoA
D65N mutant protein, pH7.5, 25°C
2.6
3-hydroxyphenylacetyl-CoA
K136A mutant protein, pH7.5, 25°C
4.1
3-hydroxyphenylacetyl-CoA
T69A mutant protein, pH7.5, 25°C
24
3-hydroxyphenylacetyl-CoA
H56A mutant protein, pH7.5, 25°C
35
3-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.105
acetyl-CoA
-
at pH 7.5 and 30°C
0.18
acetyl-CoA
wild-type protein, pH7.5, 25°C
1.1
Arachidonoyl-CoA
wild-type protein, pH7.5, 25°C
73
Arachidonoyl-CoA
pH 7.5, 37°C, wild-type
0.011
butyryl-CoA
-
at pH 7.5 and 30°C
100
butyryl-CoA
wild-type protein
25
isobutyryl-CoA
N29A mutant protein
11000
isobutyryl-CoA
wild-type protein
1.4
lauroyl-CoA
-
-
1.9
lauroyl-CoA
wild-type protein, pH7.5, 25°C
610
lauroyl-CoA
N29A mutant protein
1400
lauroyl-CoA
wild-type protein
0.054
linoleoyl-CoA
wild-type protein, pH7.5, 25°C
2900
linoleoyl-CoA
pH 7.5, 37°C, wild-type
0.09
malonyl-CoA
-
at pH 7.5 and 30°C
0.24
malonyl-CoA
wild-type protein, pH7.5, 25°C
1.4
myristoyl-CoA
-
at 37°C, in the presence of small unilamellar vesicles composed of phosphatidylcholine at 4 mM total phospholipid concentration
2.9
myristoyl-CoA
-
at 50°C
3.1
myristoyl-CoA
-
at 37°C
4
myristoyl-CoA
wild-type protein, pH7.5, 25°C
4.4
myristoyl-CoA
-
at 25°C
6
myristoyl-CoA
-
at 37°C, in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 0.5
6
myristoyl-CoA
-
at 37°C, in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 1.0
7.7
myristoyl-CoA
wild-type protein, pH7.5, 37°C
2300
myristoyl-CoA
pH 7.5, 37°C, wild-type
1.3
oleoyl-CoA
wild-type protein, pH7.5, 25°C
1.9
palmitoleoyl-CoA
wild-type protein, pH7.5, 25°C
430
palmitoleoyl-CoA
pH 7.5, 37°C, wild-type
0.0062
palmitoyl-CoA
-
at pH 7.5 and 30°C
0.28
palmitoyl-CoA
wild-type protein, pH7.5, 25°C
3
palmitoyl-CoA
-
in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 0.5
4
palmitoyl-CoA
-
in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 1.0
6900
palmitoyl-CoA
pH 7.5, 37°C, wild-type
0.35
phenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.63
phenylacetyl-CoA
-
-
5.5
stearoyl-CoA
wild-type protein, pH7.5, 25°C
290
stearoyl-CoA
pH 7.5, 37°C, wild-type
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analysis carried out with a deletion mutant lacking the first 35 amino acids DELTA1-34. Expressed in Escherichia coli as a His-tagged fusion protein
DNA and amino acid sequence determination and analysis, expression in CHO cells
DNA sequence determination and analysis of isolated and commercial clone, overexpression of His-tagged isozyme ACH2 in Escherichia coli BL21(DE3) cells
-
DNA sequence determination and analysis, chromosome mapping 1p36.2, expression in Escherichia coli
DNA sequence determination and analysis, expression in Escherichia coli BL21(DE3)
DNA sequence determination and analysis, expression in Escherichia coli fused to maltose-binding protein
DNA sequence determination and analysis, subcloning in Escherichia coli, and expression in CHO cells
DNA sequence determination and analysis, subcloning in Escherichia coli, expression fused to maltose-binding-protein in Escherichia coli strain DH10B
expressed as a GST-fusion protein in Escherichia coli
-
expressed in Escherichia coli as a His-tagged fusion protein
Q0WCE2
expressed in Escherichia coli B834(DE3)pLysS
expressed in Escherichia coli BL21(DE3)
expressed in Escherichia coli strain BL21 StarTM
expression as His-tagged enzyme in Escherichia coli and as GST-fusion protein in bacteria
-
expression in Escherichia coli
expression in Escherichia coli BL21 as His-tagged protein
expression of cDNA in chinese hamster ovary cells
from murine EST library, DNA and amino acid sequence determination and analysis, transient expression in HeLa cells, expression as inactive GST-fusion protein in bacteria
FscTE cloned into vector pET28a and expressed in Escherichia coli BL21(DE3)/pLysE
-
gene scoT, DNA and amino acid sequence determinatin and analysis, expression and functional complementation in deficient Streptomyces fradiae strain
-
gene tes B, DNA sequence determination and analysis, no sequence similarity between Escherichia coli thioesterase II and the two types of mammalian thioesterases, i.e. the chain-terminating enzymes of de novo fatty acid synthesis
gene tesB, overexpression in the Escherichia coli host strain
gene YJR019C, DNA sequence determination and analysis, subcloning in Escherichia coli, expression fused to maltose-binding-protein in Escherichia coli strain DH10B
heterologous expression of tesB in Pseudomonas putida GPp104
-
His-tagged version expressed in Escherichia coli BL21(DE3)
His-taggend version of residue 46-483 expressed in Escherichia coli BL21 (DE3 Rosetta)
-
isozymes CTE-I and MTE-I, DNA sequence and promotor analysis
-
isozymes MTE-I, His-tagged, and CTE-I, both GST-fusion proteins
-
native protein expressed using a modified pET-15b plasmid transformed into B834-(DE3)pLysS Escherichia coli cells
overexpressed with a C-terminal hexahistidine tag
-
overexpression of isozymes AtACH5and AtACH2 in Escherichia coli , AtACH2 fused to maltose-binding protein
-
recombinantly expressed in insect cells
-
the gene encoding YciA is amplified by PCR and expressed in Escherichia coli strain BL21 (DE3)
wild-type ScoT and the H224Y mutant expressed in Escherichia coli BL21(DE3)/pLysS cells. Mutants S90A and S90C expressed in Escherichia coli strain BL21Star(DE3). Mutant H210Y expressed in Escherichia coli BL21Star(DE3) cells additionally transformed with plasmid pGroESL encoding chaperones
-
-
-
expression in Escherichia coli
-
expression in Escherichia coli
-
expression in Escherichia coli
-
expression of cDNA in chinese hamster ovary cells
expression of cDNA in chinese hamster ovary cells
His-tagged version expressed in Escherichia coli BL21(DE3)
-
His-tagged version expressed in Escherichia coli BL21(DE3)
His-tagged version expressed in Escherichia coli BL21(DE3)
the gene encoding YciA is amplified by PCR and expressed in Escherichia coli strain BL21 (DE3)
the gene encoding YciA is amplified by PCR and expressed in Escherichia coli strain BL21 (DE3)
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