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Disease on EC 3.1.2.2 - palmitoyl-CoA hydrolase and Organism(s) Homo sapiens

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma.
Medium chain fatty acid synthesis in rodent mammary adenocarcinomas in vitro.
Alzheimer Disease
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Atherosclerosis
Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (?C20)-acyl chains in macrophages.
Breast Neoplasms
Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC?-p53-p21 signaling pathway.
An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma.
Evaluation of thioesterase II as a serum marker for rat mammary cancer.
Carcinogenesis
The NIEHS Predictive-Toxicology Evaluation Project.
Carcinoma
Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC?-p53-p21 signaling pathway.
Thioesterase II, a new marker enzyme for human cells of breast epithelial origin.
Carcinoma, Hepatocellular
Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase.
Cholera
Response of end bud cells from immature rat mammary gland to hormones when cultured in collagen gel.
Colonic Neoplasms
Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.
Coma
Effect of inulin on efficient production and regulatory biosynthesis of bacillomycin D in Bacillus subtilis fmbJ.
Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose.
Communicable Diseases
Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
Deficiency Diseases
Neuroprotection and lifespan extension in Ppt1(-/-) mice by NtBuHA: therapeutic implications for INCL.
Dehydration
Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis.
Discovery of a Mosaic-Like Biosynthetic Assembly Line with a Decarboxylative Off-Loading Mechanism through a Combination of Genome Mining and Imaging.
Diabetes Mellitus, Type 2
Disallowance of Acot7 in ?-cells is required for normal glucose tolerance and insulin secretion.
The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver.
Fatty Liver
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development.
Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice.
Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism.
Glucose Intolerance
Loss of ACOT7 potentiates seizures and metabolic dysfunction.
Hepatomegaly
The hypolipidemic peroxisome-proliferating drug, bis(carboxymethylthio)-1.10 decane, a dicarboxylic metabolite of tiadenol, is activated to an acylcoenzyme A thioester.
Huntington Disease
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Hypertriglyceridemia
Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats.
Infections
Identification of Low Molecular Weight Proteins and Peptides from Schistosoma mekongi Worm, Egg and Infected Mouse Sera.
Influenza, Human
Unravelling the thioesterases responsible for propionate formation in engineered Pseudomonas putida KT2440.
YesT: a new rhamnogalacturonan acetyl esterase from Bacillus subtilis.
Insulin Resistance
AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression.
Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism.
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
Intellectual Disability
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Leukemia, Myeloid, Acute
Expression level of ACOT7 influences the prognosis in acute myeloid leukemia patients.
Lipidoses
The long-chain acyl-CoA hydrolase activity in the heart of rat fed on rape-seed oil.
Liver Neoplasms, Experimental
Induction of peroxisomal beta-oxidation in 7800 C1 Morris hepatoma cells in steady state by fatty acids and fatty acid analogues.
Synergistic actions of tetradecylthioacetic acid (TTA) and dexamethasone on induction of the peroxisomal beta-oxidation and on growth inhibition of Morris hepatoma cells. Both effects are counteracted by insulin.
Lung Neoplasms
Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC?-p53-p21 signaling pathway.
Lysosomal Storage Diseases
Lysosomal storage diseases: Thioesterase mimetic reduces toxicity.
Malaria
Fatty Acid synthesis as a target for antimalarial drug discovery.
Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
Melanoma
Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells.
Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior.
Myoclonus
A girl with infantile neuronal ceroid lipofuscinosis caused by novel PPT1 mutation and paternal uniparental isodisomy of chromosome 1.
Neoplasms
A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma.
ACTH regulation of mitochondrial acyl-CoA thioesterase activity in Y1 adrenocortical tumour cells.
Dose and Effect Thresholds for Early Key Events in a PPAR?-Mediated Mode of Action.
Evaluation of thioesterase II as a serum marker for rat mammary cancer.
Evidence for the involvement of polyunsaturated fatty acids in the regulation of long-chain acyl CoA thioesterases and peroxisome proliferation in rat carcinosarcoma.
Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.
Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain.
Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression.
Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy.
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.
Novel antagonists of the thioesterase domain of human fatty acid synthase.
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity.
RAS Subcellular Localization Inversely Regulates Thyroid Tumor Growth and Dissemination.
Regulation of conidiation and antagonistic properties of the soil-borne plant beneficial fungus Trichoderma virens by a novel proline-, glycine-, tyrosine-rich protein and a GPI-anchored cell wall protein.
The mammalian START domain protein family in lipid transport in health and disease.
The tumour promoter 12-O-tetradecanoylphorbol-13-acetate increases the activities of some peroxisome-associated enzymes in in vitro cell culture.
Thioesterase II, a new marker enzyme for human cells of breast epithelial origin.
Neuroblastoma
Novel Interactive Partners of Neuroligin 3: New Aspects for Pathogenesis of Autism.
Neuroinflammatory Diseases
In a mouse model of INCL reduced S-palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation.
Neuronal Ceroid-Lipofuscinoses
A girl with infantile neuronal ceroid lipofuscinosis caused by novel PPT1 mutation and paternal uniparental isodisomy of chromosome 1.
Atypical late infantile and juvenile forms of neuronal ceroid lipofuscinosis and their diagnostic difficulties.
Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis.
Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features.
Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease.
pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease.
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Obesity
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.
A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart.
Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase.
Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism.
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
palmitoyl-coa hydrolase deficiency
Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (?C20)-acyl chains in macrophages.
Neuroprotection and lifespan extension in Ppt1(-/-) mice by NtBuHA: therapeutic implications for INCL.
[Effect of short-chain thioesterase deficiency on P(3HB-co-LA) biosynthesis in Escherichia coli].
Pancreatic Neoplasms
A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Genes for Pancreatic Cancer Risk.
Peripheral Arterial Disease
Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
Scabies
YesT: a new rhamnogalacturonan acetyl esterase from Bacillus subtilis.
Seizures
Loss of ACOT7 potentiates seizures and metabolic dysfunction.
Sepsis
Cardiomyocyte specific expression of Acyl-coA thioesterase 1 attenuates sepsis induced cardiac dysfunction and mortality.
Starvation
Inhibition of fatty acid synthesis in Escherichia coli in the absence of phospholipid synthesis and release of inhibition by thioesterase action.
Stomach Neoplasms
ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma.
Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression.
Stroke
Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.
Tuberculosis
Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Insights into the Substrate Specificity of a Thioesterase Rv0098 of Mycobacterium Tuberculosis through X-ray Crystallographic and Molecular Dynamics Studies.
Lipid biosynthesis as a target for antibacterial agents.
Tularemia
Functional expression of Francisella tularensis FabH and FabI, potential antibacterial targets.
Vision Disorders
A girl with infantile neuronal ceroid lipofuscinosis caused by novel PPT1 mutation and paternal uniparental isodisomy of chromosome 1.