Disease on EC 3.1.11.2 - exodeoxyribonuclease III

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
miRNA biogenesis-associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma.
African Swine Fever
Evolutionary relationships among large double-stranded DNA viruses that infect microalgae and other organisms as inferred from DNA polymerase genes.
Blindness
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Bloom Syndrome
A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.
Brain Neoplasms
Genomic analysis of the 55 kDa subunit of DNA polymerase epsilon in human intracranial neoplasms.
Breast Neoplasms
Genomic changes of the 55 kDa subunit of DNA polymerase epsilon in human breast cancer.
The expression of Exonuclease III from E. coli in mitochondria of breast cancer cells diminishes mitochondrial DNA repair capacity and cell survival after oxidative stress.
Carcinogenesis
Candidate mutator genes in mismatch repair-deficient thymic lymphomas: no evidence of mutations in the DNA polymerase delta gene.
Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs.
DNA polymerase delta is required for early mammalian embryogenesis.
miRNA biogenesis-associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma.
Potential role of DNA polymerase beta in gene therapy against cancer: a case for colorectal cancer.
Carcinoma, Hepatocellular
Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types.
Chickenpox
Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I.
Colonic Neoplasms
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs.
Colorectal Neoplasms
A DNA polymerase beta mutant from colon cancer cells induces mutations.
Potential role of DNA polymerase beta in gene therapy against cancer: a case for colorectal cancer.
Colorectal Neoplasms, Hereditary Nonpolyposis
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs.
Coronary Disease
Age-dependent down-regulation of DNA polymerase ?1 in human lymphocytes.
Cystic Fibrosis
Single-tube genotyping using a solid-phase method that combines alpha-phosphorothioate-mediated primer extension and ExoIII: Proof of concept with the F508del cystic fibrosis diagnosis.
Dehydration
Detection of DNA polymerase ? activity during seed germination and enhancement after salinity stress and dehydration in the plumules of indica rice (Oryza sativa L.
Diabetes Mellitus
Age-dependent down-regulation of DNA polymerase ?1 in human lymphocytes.
Diabetes Mellitus, Type 2
Potential effects of metformin in DNA BER system based on oxidative status in type 2 diabetes.
DiGeorge Syndrome
Expression of DGCR8-Dependent MicroRNAs Is Indispensable for Osteoclastic Development and Bone-Resorbing Activity.
DNA Repair-Deficiency Disorders
YqfS from Bacillus subtilis is a spore protein and a new functional member of the type IV apurinic/apyrimidinic-endonuclease family.
Encephalitis
Neurovirulence and latency of drug-resistant clinical herpes simplex viruses in animal models.
exodeoxyribonuclease (lambda-induced) deficiency
Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities.
exodeoxyribonuclease iii deficiency
A Streptomyces coelicolor antibiotic regulatory gene, absB, encodes an RNase III homolog.
Altered mRNA metabolism in ribonuclease III-deficient strains of Escherichia coli.
AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans.
Genetic mapping of a mutation that causes ribonucleases III deficiency in Escherichia coli.
Geographic Atrophy
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Hepatitis C
RNase III cleavage demonstrates a long range RNA: RNA duplex element flanking the hepatitis C virus internal ribosome entry site.
Herpes Genitalis
Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient.
Herpes Simplex
Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I.
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
Evidence that the nuclease activities associated with the herpes simplex type 1 DNA polymerase are due to the 3'-5' exonuclease.
Exonuclease III digestion of herpes simplex virus DNA.
Herpes simplex virus type I DNA polymerase. Kinetic properties of the associated 3'-5' exonuclease activity and its role in araAMP incorporation.
Identification and characterization of a Marek's disease virus gene encoding DNA polymerase.
Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells.
Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities.
Mutations within conserved motifs in the 3'-5' exonuclease domain of herpes simplex virus DNA polymerase.
On the role of proofreading exonuclease in bypass of a 1,2 d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase.
Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site.
Herpes Zoster
Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I.
Hypersensitivity
Structure of chromatin at deoxyribonucleic acid replication forks: nuclease hypersensitivity results from both prenucleosomal deoxyribonucleic acid and an immature chromatin structure.
Infections
An Ascovirus-encoded RNase III autoregulates its expression and suppresses RNA interference-mediated gene silencing.
CDP/Cux stimulates transcription from the DNA polymerase alpha gene promoter.
Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections.
Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids.
Effect of RNase III on efficiency of translation of bacteriophage T7 lysozyme mRNA.
Impaired antioxidant enzyme activity and increased DNA repair enzyme expression in hamster liver tissues related to cholangiocarcinoma development.
Mechanism of Ribonuclease III Catalytic Regulation by Serine Phosphorylation.
Neurovirulence and latency of drug-resistant clinical herpes simplex viruses in animal models.
Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient.
Nuclear activity from F9 embryonal carcinoma cells binding specifically to the enhancers of wild-type polyoma virus and PyEC mutant DNAs.
RNase III is positively regulated by T7 protein kinase.
Infertility
The RNase III family: a conserved structure and expanding functions in eukaryotic dsRNA metabolism.
Leukemia
A 3'-5' exonuclease in human leukemia cells: implications for resistance to 1-beta -D-arabinofuranosylcytosine and 9-beta -D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate.
DNA damage induced by photosensitizers in cellular and cell-free systems.
Human AP endonuclease possesses a significant activity as major 3'-5' exonuclease in human leukemia cells.
Leukemia, Erythroblastic, Acute
In situ and in vitro evidence for intragenic binding of nuclear factors at the murine c-myc locus.
Leukemia, Lymphocytic, Chronic, B-Cell
A 3'-5' exonuclease in human leukemia cells: implications for resistance to 1-beta -D-arabinofuranosylcytosine and 9-beta -D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate.
Leukemia, Lymphoid
A DNA polymerase alpha accessory protein exhibits structural and functional similarities to SV40 large tumor antigen.
Leukemia, Myeloid, Acute
A 3'-5' exonuclease in human leukemia cells: implications for resistance to 1-beta -D-arabinofuranosylcytosine and 9-beta -D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate.
Lyme Disease
RNase III Processing of rRNA in the Lyme Disease Spirochete Borrelia burgdorferi.
Lymphoma
Candidate mutator genes in mismatch repair-deficient thymic lymphomas: no evidence of mutations in the DNA polymerase delta gene.
Macular Degeneration
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Melanoma
Expression of the RNase III enzyme DROSHA is reduced during progression of human cutaneous melanoma.
Feed-forward microprocessing and splicing activities at a microRNA-containing intron.
Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression.
Mitochondrial Diseases
The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits.
Neoplasm Metastasis
Lack of mutations in DNA polymerase beta of estradiol-induced hamster kidney tumors: sequence of hamster DNA polymerase beta cDNA.
Metastasis suppressor function of NM23-H1 requires its 3';-5' exonuclease activity.
Potential contributions of antimutator activity to the metastasis suppressor function of NM23-H1.
Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression.
The metastasis suppressor NM23-H1 possesses 3'-5' exonuclease activity.
Neoplasms
A DNA polymerase beta mutant from colon cancer cells induces mutations.
A low dicer expression is associated with resistance to 5-FU-based chemoradiotherapy and a shorter overall survival in patients with oral squamous cell carcinoma.
Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy.
Biallelic Dicer1 loss mediated by aP2-Cre drives angiosarcoma.
Biological Relevance of DNA Polymerase Beta and Translesion Synthesis Polymerases to Cancer and its Treatment.
Characterization and sequence-specific binding to mouse mammary tumor virus DNA of purified activated human glucocorticoid receptor.
Detection of microRNA in Tumor Cells using Exonuclease III and Graphene Oxide-Regulated Signal Amplification.
Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.
Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.
Fluorescence detection of telomerase activity in cancer cell extracts based on autonomous exonuclease III-assisted isothermal cycling signal amplification.
Genomic analysis of the 55 kDa subunit of DNA polymerase epsilon in human intracranial neoplasms.
Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.
Human DNA polymerase {beta} polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.
Impaired antioxidant enzyme activity and increased DNA repair enzyme expression in hamster liver tissues related to cholangiocarcinoma development.
In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs.
Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions.
Lack of mutations in DNA polymerase beta of estradiol-induced hamster kidney tumors: sequence of hamster DNA polymerase beta cDNA.
MicroRNAs and cancer: past, present, and potential future.
Mutations in DNA polymerase beta mRNA of stilbene estrogen-induced kidney tumors in Syrian hamster.
New function of exonuclease and highly sensitive label-free colorimetric DNA detection.
Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations.
Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.
RT-PCR detection of the expression of the polymerase gene of a novel reptilian herpesvirus in tumor tissues of green turtles with fibropapilloma.
Silencing of human DNA polymerase ? causes replication stress and is synthetically lethal with an impaired S phase checkpoint.
The development of Wilms tumor: from WT1 and microRNA to animal models.
The enzymatic basis of cyclophosphamide specificity.
Neoplasms, Germ Cell and Embryonal
Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.
Peste-des-Petits-Ruminants
Quantitative PCR: a quality control assay for estimation of viable virus content in live attenuated goat pox vaccine.
Photosensitivity Disorders
Roles of uracil-DNA glycosylase and apyrimidinic endonucleases in the molecular 5-bromo-2'-deoxyuridine photosensitization in Escherichia coli K-12.
Systematic Probing of the Sequence Selectivity of Exonuclease III with a Photosensitization Colorimetric Assay.
Universal and label-free photosensitization colorimetric assays enabled by target-induced termini transformation of dsDNA resistant to Exo III digestion.
Pituitary Neoplasms
Characterisation of tissue-specific trans-acting factor binding to a proximal element in the rat growth hormone gene promoter.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases.
Sarcoma
Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma.
Sarcoma, Avian
Rous sarcoma virus p19 binds to specific double-stranded regions of viral RNA: effect of p19 on cleavage of viral RNA by RNase III.
Seminoma
Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.
Starvation
?40p53 is involved in the inactivation of autophagy and contributes to inhibition of cell death in HCT116-?40p53 cells.
Adaptation to carbon starvation: RNase III ensures normal expression levels of bolA1p mRNA and sigma(S).
Consequences of losing ribonuclease III on the Escherichia coli cell.
Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases.
Tuberculosis
Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis.
Critical determinants for substrate recognition and catalysis in the M. tuberculosis class II AP-endonuclease/3'-5' exonuclease III.
Mycobacterium tuberculosis class II apurinic/apyrimidinic-endonuclease/3'-5' exonuclease III exhibits DNA regulated modes of interaction with the sliding DNA ?-clamp.
Nucleotide sequence and secondary structures of precursor 16S rRNA of slow-growing mycobacteria.
Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A.
Using property based sequence motifs and 3D modeling to determine structure and functional regions of proteins.
Vaccinia
Complementation of deletion of the vaccinia virus E3L gene by the Escherichia coli RNase III gene.
DNA primase-DNA polymerase alpha from simian cells. Modulation of RNA primer synthesis by ribonucleoside triphosphates.
Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain.
Intercalating polycyclic aromatic hydrocarbon-DNA adducts poison DNA religation by Vaccinia topoisomerase and act as roadblocks to digestion by exonuclease III.
Vesicular Stomatitis
RNase III cleaves vesicular stomatitis virus genome-length RNAs but fails to cleave viral mRNA's.
Virus Diseases
Accumulation of barley stripe mosaic virus is significantly reduced in transgenic wheat plants expressing a bacterial ribonuclease.
Drosha as an interferon-independent antiviral factor.
Sequence arrangement of the 5' ends of simian virus 40 16S and 19S mRNAs.
Werner Syndrome
Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.
Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase ?-double knockdown cells.
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs.
Probing the roles of active site residues in the 3'-5' exonuclease of the Werner syndrome protein.
Regulation of WRN helicase activity in human base excision repair.
WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.
Wilms Tumor
The development of Wilms tumor: from WT1 and microRNA to animal models.