Reference on EC 3.1.1.89 - protein phosphatase methylesterase-1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hombauer, H.; Weismann, D.; Mudrak, I.; Stanzel, C.; Fellner, T.; Lackner, D.H.; Ogris, E.
Generation of active protein phosphatase 2A is coupled to holoenzyme assembly
PLoS Biol.
5
e155
2007
Saccharomyces cerevisiae
Longin, S.; Zwaenepoel, K.; Martens, E.; Louis, J.; Rondelez, E.; Goris, J.; Janssens, V.
Spatial control of protein phosphatase 2A (de)methylation
Exp. Cell Res.
314
68-81
2008
Homo sapiens
Sontag, J.; Nunbhakdi-Craig, V.; Mitterhuber, M.; Ogris, E.; Sontag, E.
Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells
J. Neurochem.
115
1455-1465
2010
Mus musculus
Ikehara, T.; Ikehara, S.; Imamura, S.; Shinjo, F.; Yasumoto, T.
Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B)
Biochem. Biophys. Res. Commun.
354
1052-1057
2007
Homo sapiens
Longin, S.; Jordens, J.; Martens, E.; Stevens, I.; Janssens, V.; Rondelez, E.; De Baere, I.; Derua, R.; Waelkens, E.; Goris, J.; Van Hoof, C.
An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator
Biochem. J.
380
111-119
2004
Oryctolagus cuniculus, Sus scrofa
Xing, Y.; Li, Z.; Chen, Y.; Stock, J.; Jeffrey, P.; Shi, Y.
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
Cell
133
154-163
2008
Homo sapiens (Q9Y570)
Ogris, E.; Du, X.; Nelson, K.; Mak, E.; Yu, X.; Lane, W.; Pallas, D.
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A
J. Biol. Chem.
274
14382-14391
1999
Homo sapiens (Q9Y570), Homo sapiens
DeGrande, S.; Little, S.; Nixon, D.; Wright, P.; Snyder, J.; Dun, W.; Murphy, N.; Kilic, A.; Higgins, R.; Binkley, P.; Boyden, P.; Carnes, C.; Anderson, M.; Hund, T.; Mohler, P.
Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart
J. Biol. Chem.
288
1032-1046
2013
Homo sapiens
Bachovchin, D.A.; Zuhl, A.M.; Speers, A.E.; Wolfe, M.R.; Weerapana, E.; Brown, S.J.; Rosen, H.; Cravatt, B.F.
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1
J. Med. Chem.
54
5229-5236
2011
Homo sapiens
Bachovchin, D.A.; Mohr, J.T.; Speers, A.E.; Wang, C.; Berlin, J.M.; Spicer, T.P.; Fernandez-Vega, V.; Chase, P.; Hodder, P.S.; Schuerer, S.C.; Nomura, D.K.; Rosen, H.; Fu, G.C.; Cravatt, B.F.
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
Proc. Natl. Acad. Sci. USA
108
6811-6816
2011
Homo sapiens
Yao, X.Q.; Li, X.C.; Zhang, X.X.; Yin, Y.Y.; Liu, B.; Luo, D.J.; Wang, Q.; Wang, J.Z.; Liu, G.P.
Glycogen synthase kinase-3beta regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1
FEBS Lett.
586
2522-2528
2012
Mus musculus
Migueleti, D.; Smetana, J.; Nunes, H.; Kobarg, J.; Zanchin, N.
Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aalpha catalytic subunit
J. Biol. Chem.
287
4853-4862
2012
Homo sapiens
Lee, C.W.; Yang, F.C.; Chang, H.Y.; Chou, H.; Tan, B.C.; Lee, S.C.
Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1
J. Biol. Chem.
289
21108-21119
2014
Homo sapiens
Longman, M.; Ranieri, A.; Avkiran, M.; Snabaitis, A.
Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory class G-protein coupled receptors in cardiomyocytes
PLoS ONE
9
e86234
2014
Rattus norvegicus
Kaur, A.; Westermarck, J.
Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1
Biochem. Soc. Trans.
44
1683-1693
2016
Mus musculus (Q8BVQ5), Homo sapiens (Q9Y570), Homo sapiens
Yabe, R.; Tsuji, S.; Mochida, S.; Ikehara, T.; Usui, T.; Ohama, T.; Sato, K.
A stable association with PME-1 may be dispensable for PP2A demethylation - implications for the detection of PP2A methylation and immunoprecipitation
FEBS open bio
8
1486-1496
2018
Mus musculus (Q8BVQ5)
Tian, H.; Lu, Y.; Liu, J.; Liu, W.; Lu, L.; Duan, C.; Gao, G.; Yang, H.
Leucine carboxyl methyltransferase downregulation and protein phosphatase methylesterase upregulation contribute toward the inhibition of protein phosphatase 2A by alpha-synuclein
Front. Aging Neurosci.
10
173
2018
Mus musculus (Q8BVQ5)
Hwang, J.; Lee, J.A.; Pallas, D.C.
Leucine carboxyl methyltransferase 1 (LCMT-1) methylates protein phosphatase 4 (PP4) and protein phosphatase 6 (PP6) and differentially regulates the stable formation of different PP4 holoenzymes
J. Biol. Chem.
291
21008-21019
2016
Mus musculus (Q8BVQ5)
Yabe, R.; Miura, A.; Usui, T.; Mudrak, I.; Ogris, E.; Ohama, T.; Sato, K.
Protein phosphatase methyl-esterase PME-1 protects protein phosphatase 2A from ubiquitin/proteasome degradation
PLoS ONE
10
e0145226
2015
Mus musculus (Q8BVQ5), Mus musculus
Nicholls, R.E.; Sontag, J.M.; Zhang, H.; Staniszewski, A.; Yan, S.; Kim, C.Y.; Yim, M.; Woodruff, C.M.; Arning, E.; Wasek, B.; Yin, D.; Bottiglieri, T.; Sontag, E.; Kandel, E.R.; Arancio, O.
PP2A methylation controls sensitivity and resistance to beta-amyloid-induced cognitive and electrophysiological impairments
Proc. Natl. Acad. Sci. USA
113
3347-3352
2016
Mus musculus (Q8BVQ5), Mus musculus
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