Reference on EC 3.1.1.84 - cocaine esterase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pindel, E.V.; Kedishvili, N.Y.; Abraham, T.L.; Brzezinski, M.R.; Zhang, J.; Dean, R.A.; Bosron, W.F.
Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin
J. Biol. Chem.
272
14769-14775
1997
Homo sapiens (O00748)
Turner, J.M.; Larsen, N.A.; Basran, A.; Barbas, C.F., 3rd; Bruce, N.C.; Wilson, I.A.; Lerner, R.A.
Biochemical characterization and structural analysis of a highly proficient cocaine esterase
Biochemistry
41
12297-12307
2002
Rhodococcus sp. (Q9L9D7)
Larsen, N.A.; Turner, J.M.; Stevens, J.; Rosser, S.J.; Basran, A.; Lerner, R.A.; Bruce, N.C.; Wilson, I.A.
Crystal structure of a bacterial cocaine esterase
Nat. Struct. Biol.
9
17-21
2002
Rhodococcus sp. (Q9L9D7)
Ko, M.C.; Narasimhan, D.; Berlin, A.A.; Lukacs, N.W.; Sunahara, R.K.; Woods, J.H.
Effects of cocaine esterase following its repeated administration with cocaine in mice
Drug Alcohol Depend.
101
202-209
2009
Rhodococcus sp. (Q9L9D7)
Gao, D.; Narasimhan, D.L.; Macdonald, J.; Brim, R.; Ko, M.C.; Landry, D.W.; Woods, J.H.; Sunahara, R.K.; Zhan, C.G.
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity
Mol. Pharmacol.
75
318-323
2009
Rhodococcus sp. (Q9L9D7)
Bresler, M.M.; Rosser, S.J.; Basran, A.; Bruce, N.C.
Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1
Appl. Environ. Microbiol.
66
904-908
2000
Rhodococcus sp. (Q9L9D7), Rhodococcus sp., Rhodococcus sp. MB1 (Q9L9D7)
Liu, J.; Hamza, A.; Zhan, C.G.
Fundamental reaction mechanism and free energy profile for (-)-cocaine hydrolysis catalyzed by cocaine esterase
J. Am. Chem. Soc.
131
11964-11975
2003
Rhodococcus sp. (Q9L9D7)
Britt, A.J.; Bruce, N.C.; Lowe, C.R.
Identification of a cocaine esterase in a strain of Pseudomonas maltophilia
J. Bacteriol.
174
2087-2094
1992
Stenotrophomonas maltophilia, Stenotrophomonas maltophilia MB11L
Collins, G.T.; Brim, R.L.; Narasimhan, D.; Ko, M.C.; Sunahara, R.K.
Zhan. C.G.; Woods. J.H.: Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats
J. Pharmacol. Exp. Ther.
331
445-455
2009
Rhodococcus sp. (Q9L9D7)
Zheng, F.; Yang, W.; Xue, L.; Hou, S.; Liu, J.; Zhan, C.
Design of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: Structural and energetic factors affecting the catalytic efficiency
Biochemistry
49
9113-9119
2010
Homo sapiens
Yang, W.; Xue, L.; Fang, L.; Chen, X.; Zhan, C.
Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine
Chem. Biol. Interact.
187
148-152
2010
Homo sapiens
Brim, R.L.; Nance, M.R.; Youngstrom, D.W.; Narasimhan, D.; Zhan, C.G.; Tesmer, J.J.; Sunahara, R.K.; Woods, J.H.
A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse
Mol. Pharmacol.
77
593-600
2010
Rhodococcus sp. (Q9L9D7), Rhodococcus sp. MB1 (Q9L9D7)
Xue, L.; Ko, M.; Tong, M.; Yang, W.; Hou, S.; Fang, L.; Liu, J.; Zheng, F.; Woods, J.; Tai, H.; Zhan, C.
Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine
Mol. Pharmacol.
79
290-297
2011
Homo sapiens
Narasimhan, D.; Collins, G.T.; Nance, M.R.; Nichols, J.; Edwald, E.; Chan, J.; Ko, M.C.; Woods, J.H.; Tesmer, J.J.; Sunahara, R.K.
Subunit stabilization and pegylation of cocaine esterase improves in vivo residence time
Mol. Pharmacol.
80
1056-1065
2011
Rhodococcus sp.
Narasimhan, D.; Nance, M.; Gao, D.; Ko, M.; MacDonald, J.; Tamburi, P.; Yoon, D.; Landry, D.; Woods, J.; Zhan, C.; Tesmer, J.; Sunahara, R.
Structural analysis of thermostabilizing mutations of cocaine esterase
Protein Eng.
23
537-547
2010
Rhodococcus sp. (Q9L9D7), Rhodococcus sp. MB1 (Q9L9D7)
Fang, L.; Chow, K.M.; Hou, S.; Xue, L.; Chen, X.; Rodgers, D.W.; Zheng, F.; Zhan, C.G.
Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification
ACS Chem. Biol.
9
1764-1772
2014
Rhodococcus sp. (Q9L9D7), Rhodococcus sp. MB1 Bresler (Q9L9D7)
Brim, R.; Noon, K.; Collins, G.; Stein, A.; Nichols, J.; Narasimhan, D.; Ko, M.; Woods, J.; Sunahara, R.
The fate of bacterial cocaine esterase (CocE): An in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination
J. Pharmacol. Exp. Ther.
340
83-95
2012
Rhodococcus sp.
Lee, T.Y.; Park, Y.S.; Garcia, G.A.; Sunahara, R.K.; Woods, J.H.; Yang, V.C.
Cell permeable cocaine esterases constructed by chemical conjugation and genetic recombination
Mol. Pharm.
9
1361-1373
2012
Rhodococcus sp. (Q9L9D7), Rhodococcus sp. MB1 (Q9L9D7)
Kim, K.; Yao, J.; Jin, Z.; Zheng, F.; Zhan, C.G.
Kinetic characterization of cholinesterases and a therapeutically valuable cocaine hydrolase for their catalytic activities against heroin and its metabolite 6-monoacetylmorphine
Chem. Biol. Interact.
293
107-114
2018
Homo sapiens (O00748)
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