Information on EC - acetylajmaline esterase

for references in articles please use BRENDA:EC3.1.1.80
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
       acetylajmaline esterase
IUBMB Comments
This plant enzyme is responsible for the last stages in the biosynthesis of the indole alkaloid ajmaline. The enzyme is highly specific for the substrates 17-O-acetylajmaline and 17-O-acetylnorajmaline as the structurally related acetylated alkaloids vinorine, vomilenine, 1,2-dihydrovomilenine and 1,2-dihydroraucaffricine cannot act as substrates . This is a novel member of the GDSL family of serine esterases/lipases.
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The enzyme appears in viruses and cellular organisms
17-O-acetylajmaline + H2O = ajmaline + acetate
show the reaction diagram
17-O-acetylnorajmaline + H2O = norajmaline + acetate
show the reaction diagram
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