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IUBMB Comments Not identical with EC 3.1.1.1 (carboxylesterase), EC 3.1.1.2 (arylesterase), EC 3.1.1.7 (acetylcholinesterase) or EC 3.1.1.8 (cholinesterase). The activity of the liver cytosol enzyme is highest with acetyl esters of aryl alcohols, and thioesters are also hydrolysed; the microsomal enzyme also hydrolyses some other negatively charged esters, with highest activity on esters of salicylate with long-chain alcohols.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms aspirin esterase, plasma aspirin esterase, aspirin-esterase, aspes, acetylsalicylic acid esterase, aspirin esterase i, aspirin esterase ii, more
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acetylsalicylic acid esterase
-
-
-
-
aspirin esterase I
-
albumin
aspirin esterase II
-
butyrylcholinesterase
esterase, aspirin
-
-
-
-
plasma aspirin esterase
-
-
aspirin esterase
-
-
-
-
aspirin hydrolase
-
-
-
-
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acetylsalicylate + H2O = salicylate + acetate
-
-
-
-
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hydrolysis of carboxylic ester
-
-
-
-
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acetylsalicylate O-acetylhydrolase
Not identical with EC 3.1.1.1 (carboxylesterase), EC 3.1.1.2 (arylesterase), EC 3.1.1.7 (acetylcholinesterase) or EC 3.1.1.8 (cholinesterase). The activity of the liver cytosol enzyme is highest with acetyl esters of aryl alcohols, and thioesters are also hydrolysed; the microsomal enzyme also hydrolyses some other negatively charged esters, with highest activity on esters of salicylate with long-chain alcohols.
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1-naphthyl acetate + H2O
1-naphthol + acetate
-
Substrates: - Products: -
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
Substrates: - Products: -
?
2-nitrophenyl butyrate + H2O
2-nitrophenol + butyrate
-
Substrates: - Products: -
?
4-acetoxybenzoate + H2O
4-hydroxybenzoate + acetate
-
Substrates: - Products: -
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
Substrates: - Products: -
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
Substrates: - Products: -
?
acetyl salicylate + H2O
salicylate + acetate
acetylsalicylate + H2O
salicylate + acetate
acetylsalicylic acid + H2O
acetate + salicylate
acetylsalicylic acid + H2O
salicylate + acetate
-
Substrates: 20 min Products: analysis and quantification of salicylate at 300 nm
?
n-butyryl salicylate + H2O
2-hydroxybenzoate + butyrate
-
Substrates: - Products: -
?
n-decanoyl salicylate + H2O
2-hydroxybenzoate + n-decanoate
-
Substrates: - Products: -
?
n-hexanoyl salicylate + H2O
2-hydroxybenzoate + n-hexanoate
-
Substrates: - Products: -
?
n-octanoyl salicylate + H2O
2-hydroxybenzoate + n-octanoate
-
Substrates: - Products: -
?
n-pentanoyl salicylate + H2O
2-hydroxybenzoate + n-pentanoate
-
Substrates: - Products: -
?
n-propionyl salicylate + H2O
2-hydroxybenzoate + propionate
-
Substrates: - Products: -
?
phenyl acetate + H2O
phenol + acetate
-
Substrates: - Products: -
?
additional information
?
-
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: the rate of aspirin hydrolysis is not determined by aspirin esterase alone, other factors are probably involved Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: fatty acid-free human albumin and human plasma are treated with aspirin for 5 min-24 h. Acetylated residues are identified by LC/MS/MS and MALDI-TOF/TOF mass spectrometry of tryptic peptides. Treatment with 0.3 mM aspirin results in acetylation of Lys-199, Lys-402, Lys-519, and Lys-545. Treatment with 20 mM aspirin results in acetylation of 26 lysines. There is no acetylation of Tyr-411, under any conditions. Acetylated lysine is stable for at least 21 days at pH 7.4, 37°C Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: active in detoxification Products: -
?
acetylsalicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetylsalicylate + H2O
salicylate + acetate
-
Substrates: - Products: -
?
acetylsalicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetylsalicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetylsalicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetylsalicylic acid + H2O
acetate + salicylate
-
Substrates: - Products: -
?
acetylsalicylic acid + H2O
acetate + salicylate
-
Substrates: aspirin is hydrolyzed inside the erythrocytes, not in plasma Products: -
?
acetylsalicylic acid + H2O
acetate + salicylate
-
Substrates: activity of recombinant PAFAH1B2, but not its family member plasma PAF acetylhydrolase, hydrolyzes acetylsalicylic acid Products: -
?
additional information
?
-
-
Substrates: no correlation between aspirin esterase activity and frailty phenotype, interleukin-6, tumour necrosis factor-alpha, or C-reactive protein Products: -
?
additional information
?
-
-
Substrates: the type 1 PAF acetylhydrolase is one of three mammalian family members of the group 7 phospholipase A2 family, a family that is unique in that all members require a short sn-2 ester such as the acetyl ester of PAF Products: -
?
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acetyl salicylate + H2O
salicylate + acetate
acetylsalicylate + H2O
salicylate + acetate
-
Substrates: - Products: -
?
acetylsalicylic acid + H2O
acetate + salicylate
additional information
?
-
-
Substrates: the type 1 PAF acetylhydrolase is one of three mammalian family members of the group 7 phospholipase A2 family, a family that is unique in that all members require a short sn-2 ester such as the acetyl ester of PAF Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: the rate of aspirin hydrolysis is not determined by aspirin esterase alone, other factors are probably involved Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: i.e. aspirin Products: -
?
acetyl salicylate + H2O
salicylate + acetate
-
Substrates: active in detoxification Products: -
?
acetylsalicylic acid + H2O
acetate + salicylate
-
Substrates: - Products: -
?
acetylsalicylic acid + H2O
acetate + salicylate
-
Substrates: aspirin is hydrolyzed inside the erythrocytes, not in plasma Products: -
?
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4-bis-nitrophenyl phosphate
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-
bis(4-nitrophenyl)hydrogen phosphate
bis-4-nitrophenyl phosphate
eserine
-
selective for aspirin esterase II
methoxy arachidonyl fluorophosphonate
-
type 1 PAF acetylhydrolase is irreversibly inhibited
paraoxon
-
complete inhibition at 0.1 mM
platelet activating factor
-
competitive
additional information
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substrate inhibition increases with increasing chain length of the fatty acid on the ester
-
bis(4-nitrophenyl)hydrogen phosphate
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irreversible, complete inhibition
bis(4-nitrophenyl)hydrogen phosphate
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i.e. BNPP, organophosphate carboxylesterase inhibitor, enzymes from intestinal and gastric mucosa are inhibited by 80% at 0.1 mM, while the liver enzyme shows only 25% inhibition
bis-4-nitrophenyl phosphate
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-
bis-4-nitrophenyl phosphate
-
-
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Asthma
Plasma esterase activity in patients with aspirin-sensitive asthma or urticaria.
Diabetes Mellitus
Serum aspirin esterase is strongly associated with glucose and lipids in healthy subjects: different association patterns in subjects with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Serum aspirin esterase is strongly associated with glucose and lipids in healthy subjects: different association patterns in subjects with type 2 diabetes mellitus.
Kidney Failure, Chronic
Serum aspirin esterase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after haemodialysis.
Neoplasms
Plasma esterases and inflammation in ageing and frailty.
Peptic Ulcer
Aspirin esterase of gastric mucosal origin.
Pneumonia
The effect of community-acquired pneumonia on plasma esterases in older people.
Reye Syndrome
Aspirin esterase activity and Reye's syndrome.
Stomach Ulcer
Gastric ulcer, aspirin esterase and aspirin.
Urticaria
Plasma esterase activity in patients with aspirin-sensitive asthma or urticaria.
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0.00043 - 0.00078
1-naphthyl acetate
0.0053 - 0.0098
2-Nitrophenyl acetate
0.017 - 0.022
2-Nitrophenyl butyrate
0.098 - 0.11
4-acetoxybenzoate
0.0042 - 0.0083
4-nitrophenyl acetate
0.0093 - 0.019
4-nitrophenyl butyrate
0.0059 - 8.85
Acetyl salicylate
1.13 - 2.17
Acetylsalicylic acid
0.799
n-Butyryl salicylate
-
pH 8.0, 37°C
0.132
n-Decanoyl salicylate
-
pH 8.0, 37°C
0.679
n-Hexanoyl salicylate
-
pH 8.0, 37°C
0.201
n-Octanoyl salicylate
-
pH 8.0, 37°C
0.983
n-Pentanoyl salicylate
-
pH 8.0, 37°C
0.576
n-Propionyl salicylate
-
pH 8.0, 37°C
0.0018 - 0.0026
phenyl acetate
additional information
additional information
-
Michaelis-Menten kinetics
-
0.00043
1-naphthyl acetate
-
pH 7.8, 25°C, isozyme I
0.00078
1-naphthyl acetate
-
pH 7.8, 25°C, isozyme II
0.0053
2-Nitrophenyl acetate
-
pH 7.8, 25°C, isozyme I
0.0098
2-Nitrophenyl acetate
-
pH 7.8, 25°C, isozyme II
0.017
2-Nitrophenyl butyrate
-
pH 7.8, 25°C, isozyme II
0.022
2-Nitrophenyl butyrate
-
pH 7.8, 25°C, isozyme I
0.098
4-acetoxybenzoate
-
pH 7.8, 25°C, isozyme I
0.11
4-acetoxybenzoate
-
pH 7.8, 25°C, isozyme II
0.0042
4-nitrophenyl acetate
-
pH 7.8, 25°C, isozyme II
0.0083
4-nitrophenyl acetate
-
pH 7.8, 25°C, isozyme I
0.0093
4-nitrophenyl butyrate
-
pH 7.8, 25°C, isozyme I
0.019
4-nitrophenyl butyrate
-
pH 7.8, 25°C, isozyme II
0.0059
Acetyl salicylate
-
pH 7.8, 25°C, isozyme II
0.447
Acetyl salicylate
-
pH 8.0, 37°C
1.33
Acetyl salicylate
-
pH 7.4, 37°C, isozyme I
8.85
Acetyl salicylate
-
pH 5.5, 37°C, isozyme II
1.13
Acetylsalicylic acid
-
recombinant catalytic subuit PAFAH1B2, pH 7.2, 37°C
2.17
Acetylsalicylic acid
-
native enzyme, pH 7.2, 37°C
0.0018
phenyl acetate
-
pH 7.8, 25°C, isozyme I
0.0026
phenyl acetate
-
pH 7.8, 25°C, isozyme II
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0.29 - 0.47
platelet activating factor
0.29
platelet activating factor
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recombinant catalytic subuit PAFAH1B2, pH 7.2, 37°C
0.47
platelet activating factor
-
native enzyme, pH 7.2, 37°C
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0.00073
-
female, plasma, isozyme I
0.00085
-
male, serum, isozyme I
0.0009
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male, plasma, isozyme I
0.00099
-
female, plasma, isozyme II
0.0012
-
female, serum, isozyme I
0.0013
-
female, serum, isozyme II
0.025
-
isozyme I, kidney
0.026
-
female, liver, isozyme II
0.029
-
female, liver, isozyme I
0.035
-
isozyme II, kidney
0.036
-
isozyme I, kidney
0.038
-
female, liver, isozyme II
0.0385
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isozyme I, liver
0.039
-
average activity, north-west indians, serum
0.04
-
female, liver, isozyme I
0.042
-
male, liver, isozyme I
0.077
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isozyme II, liver
0.08
-
isozyme II, kidney
1.2
-
purified isozyme I, substrate 4-nitrophenylacetate
1.4
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purified isozyme II, substrate 4-nitrophenylacetate
11.31
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partially purified enzyme, substrate acetyl salicylate
2.5
-
purified isozyme I, substrate acetyl salicylate
2.55
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purified isozyme II, substrate acetyl salicylate
0.001
-
male, serum, isozyme II
0.001
-
male, serum, isozyme II
0.041
-
male
0.041
-
isozyme II, liver
0.041
-
isozyme II, liver
0.049
-
male
additional information
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overview: activity of isozymes I and II from liver and plasma in male and female animales
additional information
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overview: activity of isozymes I and II from liver and plasma in male and female animales
additional information
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-
additional information
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-
additional information
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125 nmol/min/ml plasma, day hospital patients: intermediate frailty phenotype (frailty score: 2.97), average age: 84.2 years
additional information
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64 nmol/min/ml plasma, continuing, long-term care patients: frailty phenotype (frailty score: 4.47), average age: 84.9 years
additional information
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82 nmol/min/ml plasma, young/healthy phenotype control (frailty score: 0.10), Caucasian, average age: 23.2 years
additional information
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84 nmol/min/ml plasma, independent and age-matched controls (frailty score: 0.83), average age: 82.7 years
additional information
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60 nmol/ml/min in cord blood and 87 nmol/ml/min in adult blood
additional information
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overview: activity of isozymes I and II from liver and plasma in male and female animales
additional information
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-
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5.5
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isozyme II, assay at
5.5
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isozyme II, assay at
5.5
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isozyme II, assay at
5.5
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isozyme II, assay at
5.5
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isozyme II, assay at
5.5
-
isozyme II, assay at
7.4
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isozyme I, assay at
7.4
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isozyme I, assay at
7.4
-
isozyme I, assay at
7.4
-
isozyme I, assay at
7.4
-
isozyme I, assay at
7.4
-
isozyme I, assay at
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5.5 - 9
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pH 5.5: about 50% of activity maximum, pH 9: about 75% of activity maximum
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37
-
assay at
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male and non-pregnant female cattle
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brenda
male and non-pregnant female camels
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-
brenda
male and non-pregnant female goats
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-
brenda
-
-
-
brenda
2 isozymes I and II
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-
brenda
male and non-pregnant female sheep
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-
brenda
-
-
-
brenda
diabetes 2 patients and healthy individuals, higher activity in diabetes patients than in control individuals at pH 7.4, no differences at pH 5.5
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-
brenda
individuals with frailty (cognitive impairment) scores from 0.10 (young/healthy) up to 4.47
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-
brenda
Japanese subjects
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-
brenda
north-west indians
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-
brenda
2 isozymes I and II
-
-
brenda
adult male and female Wistar rats
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-
brenda
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venous blood, similar aspirin esterase activity in frailty phenotype as in young/healthy phenotype
brenda
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-
brenda
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cytosol
brenda
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-
brenda
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-
brenda
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only isozyme II
brenda
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-
brenda
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higher aspirin esterase activity contributes to the lowered response of diabetic platelets to aspirin-mediated antiplatelet therapy
brenda
-
cord blood and blood of adults
brenda
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neonatal plasma aspirin esterase activity is much lower than that in whole blood
brenda
-
about 80% of aspirin esterase activity in blood is due to the form of the enzyme on red cells
brenda
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erythrocyte aspirin hydrolysis varies among individuals
brenda
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brenda
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-
brenda
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-
brenda
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-
brenda
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-
brenda
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brenda
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-
brenda
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-
brenda
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-
brenda
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-
brenda
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enzyme activity is higher in males than in females, not due to estrous cycle
brenda
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brenda
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-
brenda
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-
brenda
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-
brenda
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-
brenda
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only isozyme II
brenda
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-
brenda
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-
brenda
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enzyme activity is higher in females than in males, not due to estrous cycle
brenda
additional information
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enzyme activity in serum of individuals of different age and nutrition status, the latter as body mass index
brenda
additional information
-
age and gender only slightly influence the enzyme activity. Activities in adults averages 76%, being greater in males with about 82%, than in females with about 70%
brenda
additional information
-
activity of isozymes I and II in different tissues of males and females, and of females at different phases of the estrous cycle, overview
brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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metabolism
-
cholesterol metabolism alterations may be associated with aspirin metabolism in older people, overview
additional information
-
no correlation of aspirin esterase with paraoxonase 1, HDL/LDL cholesterol, or HDL cholesterol contents in cord blood
physiological function
-
high aspirin esterase activity, corresponding to faster aspirin hydrolysis, thus aspirin non-responsiveness, may occur in cardiovascular disease-prone states
physiological function
-
type I platelet-activating factor acetylhydrolase is a phospholipase A2 with selectivity for acetyl residues of PAF, and acts as aspirin acetylhydrolase. The intracellular erythrocyte PAF acetylhydrolase 1 inactivates aspirin in blood, and is the major aspirin hydrolase of human blood
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C4WIL3_9HYPH
337
0
37834
TrEMBL
-
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29000
-
1 * 45000, noncatalytic subunit, + 1 * 29000, subunit alpha1 or PAFAH1B3, + 1 * 30000, subunit alpha2 or PAFAH1B2, SDS-PAGE
30000
-
1 * 45000, noncatalytic subunit, + 1 * 29000, subunit alpha1 or PAFAH1B3, + 1 * 30000, subunit alpha2 or PAFAH1B2, SDS-PAGE
35000
-
isozyme I and II, gel filtration
45000
-
1 * 45000, noncatalytic subunit, + 1 * 29000, subunit alpha1 or PAFAH1B3, + 1 * 30000, subunit alpha2 or PAFAH1B2, SDS-PAGE
57100
-
1 * 57100, SDS-PAGE
70000
-
native enzyme, gel filtration
additional information
-
3 other cytoplasmic enzymes active with aspirin are observed differing in their MW of 220000
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trimer
-
1 * 45000, noncatalytic subunit, + 1 * 29000, subunit alpha1 or PAFAH1B3, + 1 * 30000, subunit alpha2 or PAFAH1B2, SDS-PAGE
additional information
-
type I PAF acetylhydrolase is a trimer of a noncatalytic 45 kDa protein subunit associated with two catalytic subunits, PAFAH1B3 and PAFAH1B2 as homo- or heterodimers
monomer
-
1 * 57100, SDS-PAGE
monomer
-
1 * 35000, both isozymes, SDS-PAGE
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-20°C, pH 6.8, 7% loss of activity per month
-
4°C, pH 6.8, 10% loss of activity per month
-
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isozymes arylesterase I and II, to homogeneity
-
native enzyme 1400fold from erythrocytes by two different steps of anion exchange chromatography, followed by gel filtration, recombinant PAFAH1B2 or PAFAH1B3 subunits from HEK-293T cells
-
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expression of PAFAH1B2 or PAFAH1B3 subunits in HEK-293T cells
-
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medicine
-
higher aspirin esterase activity contributes to the lowered response of diabetic platelets to aspirin-mediated antiplatelet therapy
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White, K.N.; Hope, D.B.
Partial purification and characterization of a microsomal carboxylesterase specific for salicylate esters from guinea-pig liver
Biochim. Biophys. Acta
785
138-147
1984
Cavia porcellus
brenda
Kim, D.H.; Yang, Y.S.; Jakoby, W.B.
Aspirin hydrolyzing esterases from rat liver cytosol
Biochem. Pharmacol.
40
481-487
1990
Rattus norvegicus
brenda
White, K.N.; Vale, V.L.; Hope, D.B.
Identification of common forms of salicylate esterases in guinea-pig tissues similar to the microsomal aspirinases of liver
Biochem. Soc. Trans.
22
220S
1994
Cavia porcellus
brenda
Benedito, M.A.
Fluorimetric determination of tissue distribution and differences between the activity of aspirin esterases I and II in mice and rats
J. Pharm. Pharmacol.
49
273-276
1997
Mus musculus, Rattus norvegicus
brenda
Benedito, M.A.
Gender differences in the activities of aspirin-esterases in rat tissues
Braz. J. Med. Biol. Res.
31
1113-1118
1998
Rattus norvegicus
brenda
Singh, S.; Nain, C.K.; Verma, M.; Leelamma, C.O.; Goel, R.C.
Aspirin esterases in north-west indians: the influence of age and nutrition
Int. J. Clin. Pharmacol. Ther.
38
315-319
2000
Homo sapiens
brenda
Al-Qarawi, A.A.; Ali, B.H.
Variations in the normal activity of esterases in plasma and liver of camels (Camelus dromedarius), cattle (Bos indicus), sheep (Ovis aries) and goats (Capra hircus)
J. Vet. Med. A
50
201-203
2003
Bos indicus, Camelus dromedarius, Capra hircus, Ovis aries
brenda
Gresner, P.; Dolnik, M.; Waczulikova, I.; Bryszewska, M.; Sikurova, L.; Watala, C.
Increased blood plasma hydrolysis of acetylsalicylic acid in type 2 diabetic patients: a role of plasma esterases
Biochim. Biophys. Acta
1760
207-215
2006
Homo sapiens
brenda
Adebayo, G.I.; Williams, J.; Healy, S.
Aspirin esterase activity - Evidence for skewed distribution in healthy volunteers
Eur. J. Intern. Med.
18
299-303
2007
Homo sapiens
brenda
Hubbard, R.E.; OMahony, M.S.; Calver, B.L.; Woodhouse, K.W.
Plasma esterases and inflammation in ageing and frailty
Eur. J. Clin. Pharmacol.
64
895-900
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