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IUBMB Comments Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O -tetradecanoylphorbol-13-acetate from croton oil.
The enzyme appears in viruses and cellular organisms
Synonyms diacylphorbate 12-hydrolase, More, PDE74H, phorbol-12,13-diester 12-ester hydrolase, more
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diacylphorbate 12-hydrolase
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phorbol-12,13-diester 12-ester hydrolase
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additional information
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esterase 1 immunologically identical with phorboldiester hydrolase
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phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate
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hydrolysis of carboxylic ester
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12,13-diacylphorbate 12-acylhydrolase
Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O-tetradecanoylphorbol-13-acetate from croton oil.
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phorbol 12,13-dibutanoate + H2O
phorbol 13-butanoate + butanoate
phorbol 12,13-dibutanoate + H2O
phorbol 13-butanoate + butanoate
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Substrates: - Products: -
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phorbol 12,13-dibutanoate + H2O
phorbol 13-butanoate + butanoate
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phorbol 12,13-dibutanoate + H2O
phorbol 13-butanoate + butanoate
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phorbol 12,13-dibutanoate + H2O
phorbol 13-butanoate + butanoate
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Substrates: 4beta-phorbol-12beta,13alpha-dibutanoate Products: -
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phorbol 12,13-dibutanoate + H2O
phorbol 13-butanoate + butanoate
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phorbol 12,13-dibutanoate + H2O
phorbol 13-butanoate + butanoate
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Substrates: - Products: -
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Phenylmethylsulfonylfluoride
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additional information
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not inhibited by MnCl2, MgCl2, CoCl2
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Neoplasms
Phorbol-12,13-diester 12-ester hydrolase may prevent tumour promotion by phorbol diesters in skin.
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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monomer
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1 * 60000, SDS-PAGE under reducing and non-reducing conditions
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additional information
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acid-labile
80963
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additional information
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heat-labile
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-70°C, 5 months, no loss of activity
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medicine
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the enzyme may prevent tumor promotion by phorbol diesters in skin
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Shoyab, M.; Warren, T.C.; Torado, G.L.
Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver
J. Biol. Chem.
256
12529-12534
1981
Mus musculus
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Shoyab, M.; Warren, T.C.; Torado, G.J.
Phorbol-12,13-diester 12-ester hydrolase may prevent tumour promotion by phorbol diesters in skin
Nature
295
152-154
1982
Cavia porcellus, Mesocricetus auratus, Oryctolagus cuniculus, Rattus norvegicus
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Kadner, S.S.; Katz, J.; Levitz, M.; Finlay, T.H.
The 65-kDa phorbol-diester hydrolase in mouse plasma is esterase 1 and is immunologically distinct from the 56-kDa phorbol-diester hydrolase in mouse liver
J. Biol. Chem.
260
15604-15609
1985
Mus musculus
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