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Information on EC 3.1.1.51 - phorbol-diester hydrolase

for references in articles please use BRENDA:EC3.1.1.51

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IUBMB Comments

Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O-tetradecanoylphorbol-13-acetate from croton oil.

The enzyme appears in viruses and cellular organisms

Synonyms
diacylphorbate 12-hydrolase, More, PDE74H, phorbol-12,13-diester 12-ester hydrolase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate
show the reaction diagram
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