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Disease on EC 3.1.1.17 - gluconolactonase

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DISEASE
TITLE OF PUBLICATION
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Acute Radiation Syndrome
Radiation-induced gastrointestinal syndrome is exacerbated in vitamin C-insufficient SMP30/GNL knockout mice.
Acute-On-Chronic Liver Failure
Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.
Adenocarcinoma
Exogenous regucalcin negatively regulates the progression of cervical adenocarcinoma.
Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy.
Regucalcin is an androgen-target gene in the rat prostate modulating cell-cycle and apoptotic pathways.
Adenocarcinoma of Lung
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Adenoma
Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals.
Alzheimer Disease
Regucalcin as a potential biomarker for metabolic and neuronal diseases.
Argininosuccinic Aciduria
Vitamin C deficiency causes muscle atrophy and a deterioration in physical performance.
Ascorbic Acid Deficiency
Ascorbic acid deficiency affects genes for oxidation-reduction and lipid metabolism in livers from SMP30/GNL knockout mice.
Ascorbic acid deficiency leads to epidermal atrophy and UVB-induced skin pigmentation in SMP30/GNL knockout hairless mice.
Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30/GNL knockout mice.
Effects of ascorbic acid deficiency on protein and lipid oxidation in livers from SMP30/GNL knockout mice.
Effects of vitamin C deficiency on the skin of the senescence marker protein-30 (SMP30) knockout mouse.
Transcriptome Analysis of Skin from SMP30/GNL Knockout Mice Reveals the Effect of Ascorbic Acid Deficiency on Skin and Hair.
Vitamin C deficiency accelerates bone loss inducing an increase in PPAR-? expression in SMP30 knockout mice.
Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice.
Vitamin C deficiency increases the binucleation of hepatocytes in SMP30 knock-out mice.
Vitamin C. Biosynthesis, recycling and degradation in mammals.
Atherosclerosis
A common mutation in paraoxonase-2 results in impaired lactonase activity.
A Multi-Omics Analysis of PON1 Lactonase Activity in Relation to Human Health and Disease.
Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis.
Increased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile.
Paraoxonase 1 gene transfer lowers vascular oxidative stress and improves vasomotor function in apolipoprotein E-deficient mice with pre-existing atherosclerosis.
Relationship between serum paraoxonase and homocysteine thiolactonase activity, adipokines, and asymmetric dimethyl arginine concentrations in renal transplant patients.
Risk of carotid atherosclerosis is associated with low serum paraoxonase (PON1) activity among arsenic exposed residents in Southwestern Taiwan.
Serum cystatin C is a determinant of paraoxonase activity in hemodialyzed and renal transplanted patients.
Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis.
Bone Resorption
Bone loss in regucalcin transgenic rats: enhancement of osteoclastic cell formation from bone marrow of rats with increasing age.
Expression of regucalcin in rat bone marrow cells: involvement of osteoclastic bone resorption in regucalcin transgenic rats.
Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats.
Regucalcin stimulates osteoclast-like cell formation in mouse marrow cultures.
Brain Diseases
Regucalcin as a potential biomarker for metabolic and neuronal diseases.
Breast Neoplasms
3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements.
5?-Dihydrotestosterone regulates the expression of L-type calcium channels and calcium-binding protein regucalcin in human breast cancer cells with suppression of cell growth.
Correction: 3, 3'5 Triiodo L Thyronine Induces Apoptosis in Human Breast Cancer MCF-7cells, Repressing SMP30 Expression through Negative Thyroid Response Elements.
Exogenous regucalcin suppresses the proliferation of human breast cancer MDA-MB-231 bone metastatic cells in vitro.
Increased regucalcin gene expression extends survival in breast cancer patients: Overexpression of regucalcin suppresses the proliferation and metastatic bone activity in MDA-MB-231 human breast cancer cells in vitro.
Paired measurement of serum amyloid A (SAA) and paraoxonase 1 (PON1) as useful markers in breast cancer recurrence.
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals.
Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis.
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
[Erratum] Exogenous regucalcin suppresses the proliferation of human breast cancer MDA-MB-231 bone metastatic cells in vitro.
Carcinogenesis
2,3,7,8?tetrachlorodibenzo?p?dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling.
Alternatively spliced variants of the regucalcin gene in various human normal and tumor tissues.
Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro.
Extracellular regucalcin suppresses colony formation and growth independent of tumor suppressor p53 in human mammary epithelial cells.
Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis.
Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy.
Overexpression of Regucalcin Suppresses the Growth of Human Osteosarcoma Cells in Vitro: Repressive Effect of Extracellular Regucalcin.
Prolonged survival in hepatocarcinoma patients with increased regucalcin gene expression: HepG2 cell proliferation is suppressed by overexpression of regucalcin in vitro.
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish.
Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro.
Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis.
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro.
The phytochemical p-hydroxycinnamic acid suppresses the growth and stimulates the death in human liver cancer HepG2 cells.
The transcriptional regulation of regucalcin gene expression.
Carcinoma
Over-expression of senescence Marker Protein-30 decreases reactive oxygen species in human hepatic carcinoma Hep G2 cells.
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro.
Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals.
Carcinoma, Hepatocellular
Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver.
Ca2+ administration stimulates the binding of AP-1 factor to the 5'-flanking region of the rat gene for the Ca2+-binding protein regucalcin.
Diagnostic Value of Serum SMP30 and Anti-SMP30 Antibody in Hepatocellular Carcinoma.
Enhancement of protein tyrosine phosphatase activity in the proliferation of cloned rat hepatoma H4-II-E cells: suppressive role of endogenous regucalcin.
Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro.
Expression of calcium-binding protein regucalcin mRNA in hepatoma cells.
Expression of calcium-binding protein regucalcin mRNA in the cloned human hepatoma cells (HepG2): stimulation by insulin.
Expression of calcium-binding protein regucalcin mRNA in the cloned rat hepatoma cells (H4-II-E) is stimulated through Ca2+ signaling factors: involvement of protein kinase C.
Inhibition of SMP30 Gene Expression Influences the Biological Characteristics of Human Hep G2 Cells.
Involvement of intracellular signaling factors in the serum-enhanced Ca2+-binding protein regucalcin mRNA expression in the cloned rat hepatoma cells (H4-II-E).
Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy.
Lactonase and C-acylase activity of hepatoma.
Laminarin from Seaweed (Laminaria japonica) Inhibits Hepatocellular Carcinoma Through Upregulating Senescence Marker Protein-30.
Overexpression of regucalcin enhances glucose utilization and lipid production in cloned rat hepatoma H4-II-E cells: Involvement of insulin resistance.
Overexpression of regucalcin modulates tumor-related gene expression in cloned rat hepatoma H4-II-E cells.
Overexpression of regucalcin suppresses apoptotic cell death in the cloned rat hepatoma H4-II-E cells induced by a naturally occurring isothiocyanate sulforaphane.
Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by insulin or insulin-like growth factor-I.
Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by lipopolysaccharide, PD 98059, dibucaine, or Bay K 8644.
Overexpression of regucalcin suppresses cell death in cloned rat hepatoma H4-II-E cells induced by tumor necrosis factor-alpha or thapsigargin.
Overexpression of regucalcin suppresses cell proliferation in cloned rat hepatoma H4-II-E cells: involvement of intracellular signaling factors and cell cycle-related genes.
Overexpression of regucalcin suppresses gene expression of insulin signaling-related proteins in cloned rat hepatoma H4-II-E cells: Involvement of insulin resistance.
Promoter characterization of the rat gene for Ca2+-binding protein regucalcin. Transcriptional regulation by signaling factors.
Regucalcin and cell regulation: role as a suppressor protein in signal transduction.
Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats.
Regulatory role of endogenous regucalcin in the enhancement of nuclear deoxyribonuleic acid synthesis with proliferation of cloned rat hepatoma cells (H4-II-E).
Role of endogenous regucalcin in protein tyrosine phosphatase regulation in the cloned rat hepatoma cells (H4-II-E).
Role of regucalcin in liver nuclear function: binding of regucalcin to nuclear protein or DNA and modulation of tumor-related gene expression.
Role of regucalcin in maintaining cell homeostasis and function (review).
Senescence marker protein 30 (SMP30) serves as a potential prognostic indicator in hepatocellular carcinoma.
Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells.
Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma.
Soluble expression of recombinant human SMP30 for detecting serum SMP30 antibody levels in hepatocellular carcinoma patients.
Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue.
Suppression of cell proliferation and deoxyribonucleic acid synthesis in the cloned rat hepatoma H4-II-E cells overexpressing regucalcin.
Suppressive effect of endogenous regucalcin on nitric oxide synthase activity in cloned rat hepatoma H4-II-E cells overexpressing regucalcin.
Suppressive role of endogenous regucalcin in the enhancement of protein kinase activity with proliferation of cloned rat hepatoma cells (H4-II-E).
Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis.
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways.
The calcium channel agonist Bay K 8644 promotes the growth of human liver cancer HepG2 cells in vitro: suppression with overexpressed regucalcin.
Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin.
Transcriptional regulation of human paraoxonase 1 by PXR and GR in human hepatoma cells.
Carcinoma, Non-Small-Cell Lung
Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy.
Carcinoma, Renal Cell
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro.
Cardiomegaly
Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction.
Cardiovascular Diseases
Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease.
PON1 lactonase activity and its association with cardiovascular disease.
Carotid Artery Diseases
Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease.
Cataract
Downregulation of SMP30 in senescent human lens epithelial cells.
Effect of senescence marker protein 30 on the proliferation and apoptosis of human lens epithelial cells SRA01/04.
Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice.
Expressions of Senescence-Associated ?-Galactosidase and Senescence Marker Protein-30 are Associated with Lens Epithelial Cell Apoptosis.
Colitis
Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity.
Colitis-Associated Neoplasms
Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity.
Colorectal Neoplasms
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Coronary Artery Disease
Mutations in the human paraoxonase 1 gene: frequencies, allelic linkages, and association with coronary artery disease.
Coronary Disease
Human paraoxonase 1 gene polymorphisms and the risk of coronary heart disease: a community-based study.
Low protective PON1 lactonase activity in an Arab population with high rates of coronary heart disease and diabetes.
Quantitative Assessment of the Influence of Paraoxonase 1 Activity and Coronary Heart Disease Risk.
Cystic Fibrosis
Paraoxonase 2 Serves a Proapopotic Function in Mouse and Human Cells in Response to the Pseudomonas aeruginosa Quorum-sensing Molecule N-(3-Oxododecanoyl)-homoserine Lactone.
Dementia
A Multi-Omics Analysis of PON1 Lactonase Activity in Relation to Human Health and Disease.
Dementia, Vascular
Melatonin ameliorates brain oxidative stress and upregulates senescence marker protein-30 and osteopontin in a rat model of vascular dementia.
Diabetes Mellitus
Effect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Rats.
Paraoxonase lactonase activity, inflammation and antioxidant status in plasma of patients with type 1 diabetes mellitus.
Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type I diabetes mellitus.
Diabetes Mellitus, Type 1
Paraoxonase lactonase activity, inflammation and antioxidant status in plasma of patients with type 1 diabetes mellitus.
Diabetes Mellitus, Type 2
Decreased paraoxonase 2 enzymatic activity in monocyte/macrophages cells. A comparative in vivo and in vitro study for diabetes.
Diabetes, Gestational
Lactonase activity and status of paraoxonase 1 and oxidative stress in neonates of women with gestational diabetes mellitus.
Lactonase Activity, Status, and Genetic Variations of Paraoxonase 1 in Women with Gestational Diabetes Mellitus.
Diabetic Foot
Quorum Quenching Lactonase Strengthens Bacteriophage and Antibiotic Arsenal Against Pseudomonas aeruginosa Clinical Isolates.
Diabetic Nephropathies
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Kidney tissue proteomics reveals regucalcin downregulation in response to diabetic nephropathy with reflection in urinary exosomes.
Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type I diabetes mellitus.
Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes.
Fatty Liver
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.
Foot Ulcer
Quorum Quenching Lactonase Strengthens Bacteriophage and Antibiotic Arsenal Against Pseudomonas aeruginosa Clinical Isolates.
gluconolactonase deficiency
Age-related oxidant stress with senescence marker protein-30 deficiency plays a pivotal role in coronary artery spasm.
Anti-inflammatory activity of SMP30 modulates NF-?B through protein tyrosine kinase/phosphatase balance.
Coronary Artery Spasm Related to Thiol Oxidation and Senescence Marker Protein-30 in Aging.
Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion.
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.
Senescence Marker Protein 30 Deficiency Exacerbates Pulmonary Hypertension in Hypoxia-Exposed Mice.
Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation.
Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity.
Senescence Marker Protein-30 (SMP30) Deficiency Impairs Myocardium-Induced Dilation of Coronary Arterioles Associated with Reactive Oxygen Species.
Senescence marker protein-30 deficiency impairs angiogenesis under ischemia.
Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes.
SMP30 deficiency causes increased oxidative stress in brain.
SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.
Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice.
Glucose Intolerance
Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.
Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion.
Glucose Metabolism Disorders
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Hearing Loss
Effect of vitamin C depletion on age-related hearing loss in SMP30/GNL knockout mice.
Heart Failure
Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review).
Hepatitis
Potential sensitivity of hepatic specific protein regucalcin as a marker of chronic liver injury.
The transcriptional regulation of regucalcin gene expression.
Hepatitis B
Serum lactonase and arylesterase activities in alcoholic hepatitis and hepatitis B.
Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.
Hepatitis B, Chronic
Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.
Hepatitis, Alcoholic
Serum lactonase and arylesterase activities in alcoholic hepatitis and hepatitis B.
Hepatitis, Chronic
Diagnostic Value of Serum SMP30 and Anti-SMP30 Antibody in Hepatocellular Carcinoma.
Hyperinsulinism
Stem Cell Replacement Improves Expression of SMP30 in db/db Mice.
Hyperlipidemias
Change in lipid components in the adipose and liver tissues of regucalcin transgenic rats with increasing age: suppression of leptin and adiponectin gene expression.
Exogenous regucalcin suppresses osteoblastogenesis and stimulates adipogenesis in mouse bone marrow culture.
Hyperlipidemia is induced in regucalcin transgenic rats with increasing age.
Involvement of regucalcin in lipid metabolism and diabetes.
Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats.
Role of regucalcin in maintaining cell homeostasis and function (review).
Hypertension
Candidate gene polymorphisms related to lipid metabolism in Asian Indians living in Durban, South Africa.
Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes.
Hypertension, Pulmonary
Senescence Marker Protein 30 Deficiency Exacerbates Pulmonary Hypertension in Hypoxia-Exposed Mice.
Hyperthyroidism
Alterations in expression of senescence marker protein-30 gene by 3,3',5-triiodo-L-thyronine (T3).
Hypoalphalipoproteinemias
Paraoxonase-1 activities in individuals with different HDL circulating levels: Implication in reverse cholesterol transport and early vascular damage.
Infections
A preliminary study of paraoxonase-1 in infected patients with an indwelling central venous catheter.
Effects of dietary Lactobacillus plantarum and AHL lactonase on the control of Aeromonas hydrophila infection in tilapia.
In vivo evaluation of a recombinant N-acylhomoserine lactonase formulated in a hydrogel using a murine model infected with MDR Pseudomonas aeruginosa clinical isolate, CCASUP2.
Lactonase Specificity Is Key to Quorum Quenching in Pseudomonas aeruginosa.
Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma.
The Redox Systems of Plasmodium falciparum and Plasmodium vivax: Comparison, In silico Analyses and Inhibitor Studies.
Infertility
Detection and localization of regucalcin in spermatozoa of water buffalo (Bubalus bubalis): A calcium-regulating multifunctional protein.
Insulin Resistance
Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease.
Involvement of regucalcin in lipid metabolism and diabetes.
Overexpression of regucalcin enhances glucose utilization and lipid production in cloned rat hepatoma H4-II-E cells: Involvement of insulin resistance.
Overexpression of regucalcin suppresses gene expression of insulin signaling-related proteins in cloned rat hepatoma H4-II-E cells: Involvement of insulin resistance.
Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.
Paraoxonase-1 (PON1) Status in Pancreatic Cancer: Relation to Clinical Parameters.
Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats.
Study of Cellular Senescence and Vitamin D Deficiency in Nonalcoholic Fatty Liver Disease and The Potential Protective Effect of Vitamin D Supplementation.
Keratoconus
[Correlations of telomere length changing and pathogeny of keratoconus]
Kidney Diseases
Kidney tissue proteomics reveals regucalcin downregulation in response to diabetic nephropathy with reflection in urinary exosomes.
Kidney Failure, Chronic
Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease.
Effect of nutritional status on human paraoxonase-1 activity in patients with chronic kidney disease.
Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy.
Paraoxonase 1 in chronic kidney failure.
Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis.
Kidney Neoplasms
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro.
Liver Cirrhosis
Diagnostic Value of Serum SMP30 and Anti-SMP30 Antibody in Hepatocellular Carcinoma.
Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats.
Senescence Marker Protein 30: Functional and Structural Insights to its Unknown Physiological Function.
Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice.
Liver Diseases
Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease.
Involvement of regucalcin in lipid metabolism and diabetes.
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.
Serum lactonase and arylesterase activities in alcoholic hepatitis and hepatitis B.
Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.
The measurement of the lactonase activity of paraoxonase-1 in the clinical evaluation of patients with chronic liver impairment.
Liver Failure, Acute
Senescence marker protein 30 in acute liver failure: validation of a mass spectrometry proteomics assay.
Liver Neoplasms
Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver.
Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro.
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
SP1 suppresses phorbol 12-myristate 13-acetate induced up-regulation of human regucalcin expression in liver cancer cells.
The calcium channel agonist Bay K 8644 promotes the growth of human liver cancer HepG2 cells in vitro: suppression with overexpressed regucalcin.
Liver Neoplasms, Experimental
Expression of calcium-binding protein regucalcin mRNA in hepatoma cells.
Lung Neoplasms
Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy.
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Malnutrition
Leptin and adiponectin as new markers of undernutrition in cancer.
Metabolic Diseases
Regucalcin as a potential biomarker for metabolic and neuronal diseases.
The transcriptional regulation of regucalcin gene expression.
Metabolic Syndrome
Ciprofibrate increases paraoxonase activity in patients with metabolic syndrome.
Neoplasm Metastasis
Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma.
Neoplasms
17?-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30.
2,3,7,8?Tetrachlorodibenzo?p?dioxin suppresses the growth of human liver cancer HepG2 cells in vitro: Involvement of cell signaling factors.
Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence.
Alternatively spliced variants of the regucalcin gene in various human normal and tumor tissues.
Comparison of several commonly used detection indicators of cell senescence.
Crosstalk Between Adipokines and Paraoxonase 1: A New Potential Axis Linking Oxidative Stress and Inflammation.
Exogenous regucalcin negatively regulates the progression of cervical adenocarcinoma.
Exogenous regucalcin stimulates osteoclastogenesis and suppresses osteoblastogenesis through NF-?B activation.
Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro.
Exogenous regucalcin suppresses the proliferation of human breast cancer MDA-MB-231 bone metastatic cells in vitro.
Extracellular regucalcin suppresses colony formation and growth independent of tumor suppressor p53 in human mammary epithelial cells.
Growth inhibition of cultured human liver carcinoma cells by Ki-energy (life-energy): scientific evidence for Ki-effects on cancer cells.
Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis.
Hormonal regulation of regucalcin mRNA expression in osteoblastic MC3T3-E1 cells.
Increased regucalcin gene expression extends survival in breast cancer patients: Overexpression of regucalcin suppresses the proliferation and metastatic bone activity in MDA-MB-231 human breast cancer cells in vitro.
Inhibition of SMP30 Gene Expression Influences the Biological Characteristics of Human Hep G2 Cells.
Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy.
Laminarin from Seaweed (Laminaria japonica) Inhibits Hepatocellular Carcinoma Through Upregulating Senescence Marker Protein-30.
Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy.
Novel Royal Jelly Proteins Identified by Gel-based and Gel-Free Proteomics.
Overexpression of regucalcin modulates tumor-related gene expression in cloned rat hepatoma H4-II-E cells.
Overexpression of regucalcin suppresses cell death in cloned rat hepatoma H4-II-E cells induced by tumor necrosis factor-alpha or thapsigargin.
Overexpression of regucalcin suppresses cell response for tumor necrosis factor-alpha or transforming growth factor-beta1 in cloned normal rat kidney proximal tubular epithelial NRK52E cells.
Overexpression of Regucalcin Suppresses the Growth of Human Osteosarcoma Cells in Vitro: Repressive Effect of Extracellular Regucalcin.
Paraoxonase-1 (PON1) Status in Pancreatic Cancer: Relation to Clinical Parameters.
Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells.
Prolonged survival in hepatocarcinoma patients with increased regucalcin gene expression: HepG2 cell proliferation is suppressed by overexpression of regucalcin in vitro.
Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro.
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro.
Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones.
Regucalcin stimulates osteoclast-like cell formation in mouse marrow cultures.
Senescence marker protein 30 (SMP30) serves as a potential prognostic indicator in hepatocellular carcinoma.
Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish.
Senescence Marker Protein 30: Functional and Structural Insights to its Unknown Physiological Function.
Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis.
Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells.
Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma.
Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro.
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Targeting ?-catenin in hepatocellular cancers induced by coexpression of mutant ?-catenin and K-Ras in mice.
The calcium channel agonist Bay K 8644 promotes the growth of human liver cancer HepG2 cells in vitro: suppression with overexpressed regucalcin.
The Emerging Role of Regucalcin as a Tumor Suppressor: Facts and Views.
The role of regucalcin in bone homeostasis: involvement as a novel cytokine.
The transcriptional regulation of regucalcin gene expression.
Neurodegenerative Diseases
Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation.
Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis.
Non-alcoholic Fatty Liver Disease
Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease.
Involvement of regucalcin in lipid metabolism and diabetes.
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.
Study of Cellular Senescence and Vitamin D Deficiency in Nonalcoholic Fatty Liver Disease and The Potential Protective Effect of Vitamin D Supplementation.
Obesity
A Multi-Omics Analysis of PON1 Lactonase Activity in Relation to Human Health and Disease.
Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women.
Involvement of regucalcin gene promoter region-related protein-p117, a transcription factor, in human obesity.
Obesity, Abdominal
Anti-atherogenic properties of high-density lipoproteins in psychiatric patients before and after two months of atypical anti-psychotic therapy.
Obesity, Morbid
Increased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile.
Osteomalacia
The role of regucalcin in bone homeostasis: involvement as a novel cytokine.
Osteoporosis
Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats.
Role of regucalcin in maintaining cell homeostasis and function (review).
Senescence Marker Protein 30: Functional and Structural Insights to its Unknown Physiological Function.
Osteosarcoma
Overexpression of Regucalcin Suppresses the Growth of Human Osteosarcoma Cells in Vitro: Repressive Effect of Extracellular Regucalcin.
Overweight
Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women.
Paraoxonase, arylesterase and lactonase activities of paraoxonase-1 (PON1) in obese and severely obese women.
Pancreatic Neoplasms
Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro.
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro.
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Parkinson Disease
Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation.
Pneumonia
An antifouling peptide-based biosensor for determination of Streptococcus pneumonia markers in human serum.
Inhaled lactonase reduces Pseudomonas aeruginosa quorum sensing and mortality in rat pneumonia.
Polycystic Ovary Syndrome
Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis.
Prostatic Neoplasms
Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells.
Regucalcin is expressed in rat mammary gland and prostate and down-regulated by 17beta-estradiol.
Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones.
Regucalcin promotes dormancy of prostate cancer.
Suppressed glycolytic metabolism in the prostate of transgenic rats overexpressing calcium-binding protein regucalcin underpins reduced cell proliferation.
Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis.
Pulmonary Emphysema
Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice.
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.
Renal Insufficiency
Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease.
The potential role of regucalcin in kidney cell regulation: Involvement in renal failure (Review).
Renal Insufficiency, Chronic
Circulating Lactonase Activity but Not Protein Level of PON-1 Predicts Adverse Outcomes in Subjects with Chronic Kidney Disease.
Retinoblastoma
2,3,7,8?tetrachlorodibenzo?p?dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling.
Extracellular regucalcin suppresses colony formation and growth independent of tumor suppressor p53 in human mammary epithelial cells.
The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro.
The phytochemical p-hydroxycinnamic acid suppresses the growth and stimulates the death in human liver cancer HepG2 cells.
Scabies
Effects of AttM lactonase on the pathogenicity of Streptomyces scabies.
Scurvy
Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy.
[Anti-aging research using SMP30/GNL knockout mice]
Spasm
Age-related oxidant stress with senescence marker protein-30 deficiency plays a pivotal role in coronary artery spasm.
Coronary Artery Spasm Related to Thiol Oxidation and Senescence Marker Protein-30 in Aging.
Starvation
Gene transcription during exposure to, and recovery from, cold and desiccation stress in Drosophila melanogaster.
The role of Rsv1 in the transcriptional regulation of genes involved in sugar metabolism for long-term survival.
Thrombosis
Circulating Fibroblast Growth Factor-23 Level and Paraoxonase-1 Lactonase Activity in Chronic Hemodialysis Patients: Their Impact on the Incidence of Native AV Fistula Thrombosis.
Uremia
PON-1 carbamylation is enhanced in HDL of uremia patients.
Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis.
Wound Infection
Efficacy of purified lactonase and ciprofloxacin in preventing systemic spread of Pseudomonas aeruginosa in murine burn wound model.