Disease on EC 3.1.1.17 - gluconolactonase
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Acute Radiation Syndrome
Radiation-induced gastrointestinal syndrome is exacerbated in vitamin C-insufficient SMP30/GNL knockout mice.
Acute-On-Chronic Liver Failure
Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.
Adenocarcinoma
Exogenous regucalcin negatively regulates the progression of cervical adenocarcinoma.
Adenocarcinoma
Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy.
Adenocarcinoma
Regucalcin is an androgen-target gene in the rat prostate modulating cell-cycle and apoptotic pathways.
Adenocarcinoma of Lung
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Adenocarcinoma of Lung
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Adenoma
Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals.
Argininosuccinic Aciduria
Vitamin C deficiency causes muscle atrophy and a deterioration in physical performance.
Ascorbic Acid Deficiency
Ascorbic acid deficiency affects genes for oxidation-reduction and lipid metabolism in livers from SMP30/GNL knockout mice.
Ascorbic Acid Deficiency
Ascorbic acid deficiency leads to epidermal atrophy and UVB-induced skin pigmentation in SMP30/GNL knockout hairless mice.
Ascorbic Acid Deficiency
Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30/GNL knockout mice.
Ascorbic Acid Deficiency
Effects of ascorbic acid deficiency on protein and lipid oxidation in livers from SMP30/GNL knockout mice.
Ascorbic Acid Deficiency
Effects of vitamin C deficiency on the skin of the senescence marker protein-30 (SMP30) knockout mouse.
Ascorbic Acid Deficiency
Transcriptome Analysis of Skin from SMP30/GNL Knockout Mice Reveals the Effect of Ascorbic Acid Deficiency on Skin and Hair.
Ascorbic Acid Deficiency
Vitamin C deficiency accelerates bone loss inducing an increase in PPAR-? expression in SMP30 knockout mice.
Ascorbic Acid Deficiency
Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice.
Ascorbic Acid Deficiency
Vitamin C deficiency increases the binucleation of hepatocytes in SMP30 knock-out mice.
Atherosclerosis
A Multi-Omics Analysis of PON1 Lactonase Activity in Relation to Human Health and Disease.
Atherosclerosis
Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis.
Atherosclerosis
Increased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile.
Atherosclerosis
Paraoxonase 1 gene transfer lowers vascular oxidative stress and improves vasomotor function in apolipoprotein E-deficient mice with pre-existing atherosclerosis.
Atherosclerosis
Relationship between serum paraoxonase and homocysteine thiolactonase activity, adipokines, and asymmetric dimethyl arginine concentrations in renal transplant patients.
Atherosclerosis
Risk of carotid atherosclerosis is associated with low serum paraoxonase (PON1) activity among arsenic exposed residents in Southwestern Taiwan.
Atherosclerosis
Serum cystatin C is a determinant of paraoxonase activity in hemodialyzed and renal transplanted patients.
Atherosclerosis
Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis.
Bone Resorption
Bone loss in regucalcin transgenic rats: enhancement of osteoclastic cell formation from bone marrow of rats with increasing age.
Bone Resorption
Expression of regucalcin in rat bone marrow cells: involvement of osteoclastic bone resorption in regucalcin transgenic rats.
Bone Resorption
Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats.
Bone Resorption
Regucalcin stimulates osteoclast-like cell formation in mouse marrow cultures.
Breast Neoplasms
3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements.
Breast Neoplasms
5?-Dihydrotestosterone regulates the expression of L-type calcium channels and calcium-binding protein regucalcin in human breast cancer cells with suppression of cell growth.
Breast Neoplasms
Correction: 3, 3'5 Triiodo L Thyronine Induces Apoptosis in Human Breast Cancer MCF-7cells, Repressing SMP30 Expression through Negative Thyroid Response Elements.
Breast Neoplasms
Exogenous regucalcin suppresses the proliferation of human breast cancer MDA-MB-231 bone metastatic cells in vitro.
Breast Neoplasms
Increased regucalcin gene expression extends survival in breast cancer patients: Overexpression of regucalcin suppresses the proliferation and metastatic bone activity in MDA-MB-231 human breast cancer cells in vitro.
Breast Neoplasms
Paired measurement of serum amyloid A (SAA) and paraoxonase 1 (PON1) as useful markers in breast cancer recurrence.
Breast Neoplasms
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Breast Neoplasms
Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals.
Breast Neoplasms
Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis.
Breast Neoplasms
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Breast Neoplasms
[Erratum] Exogenous regucalcin suppresses the proliferation of human breast cancer MDA-MB-231 bone metastatic cells in vitro.
Carcinogenesis
2,3,7,8?tetrachlorodibenzo?p?dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling.
Carcinogenesis
Alternatively spliced variants of the regucalcin gene in various human normal and tumor tissues.
Carcinogenesis
Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro.
Carcinogenesis
Extracellular regucalcin suppresses colony formation and growth independent of tumor suppressor p53 in human mammary epithelial cells.
Carcinogenesis
Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis.
Carcinogenesis
Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy.
Carcinogenesis
Overexpression of Regucalcin Suppresses the Growth of Human Osteosarcoma Cells in Vitro: Repressive Effect of Extracellular Regucalcin.
Carcinogenesis
Prolonged survival in hepatocarcinoma patients with increased regucalcin gene expression: HepG2 cell proliferation is suppressed by overexpression of regucalcin in vitro.
Carcinogenesis
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Carcinogenesis
Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish.
Carcinogenesis
Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro.
Carcinogenesis
Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis.
Carcinogenesis
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Carcinogenesis
The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro.
Carcinogenesis
The phytochemical p-hydroxycinnamic acid suppresses the growth and stimulates the death in human liver cancer HepG2 cells.
Carcinoma
Over-expression of senescence Marker Protein-30 decreases reactive oxygen species in human hepatic carcinoma Hep G2 cells.
Carcinoma
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro.
Carcinoma
Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals.
Carcinoma, Hepatocellular
Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver.
Carcinoma, Hepatocellular
Ca2+ administration stimulates the binding of AP-1 factor to the 5'-flanking region of the rat gene for the Ca2+-binding protein regucalcin.
Carcinoma, Hepatocellular
Diagnostic Value of Serum SMP30 and Anti-SMP30 Antibody in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Enhancement of protein tyrosine phosphatase activity in the proliferation of cloned rat hepatoma H4-II-E cells: suppressive role of endogenous regucalcin.
Carcinoma, Hepatocellular
Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro.
Carcinoma, Hepatocellular
Expression of calcium-binding protein regucalcin mRNA in hepatoma cells.
Carcinoma, Hepatocellular
Expression of calcium-binding protein regucalcin mRNA in the cloned human hepatoma cells (HepG2): stimulation by insulin.
Carcinoma, Hepatocellular
Expression of calcium-binding protein regucalcin mRNA in the cloned rat hepatoma cells (H4-II-E) is stimulated through Ca2+ signaling factors: involvement of protein kinase C.
Carcinoma, Hepatocellular
Inhibition of SMP30 Gene Expression Influences the Biological Characteristics of Human Hep G2 Cells.
Carcinoma, Hepatocellular
Involvement of intracellular signaling factors in the serum-enhanced Ca2+-binding protein regucalcin mRNA expression in the cloned rat hepatoma cells (H4-II-E).
Carcinoma, Hepatocellular
Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy.
Carcinoma, Hepatocellular
Laminarin from Seaweed (Laminaria japonica) Inhibits Hepatocellular Carcinoma Through Upregulating Senescence Marker Protein-30.
Carcinoma, Hepatocellular
Overexpression of regucalcin enhances glucose utilization and lipid production in cloned rat hepatoma H4-II-E cells: Involvement of insulin resistance.
Carcinoma, Hepatocellular
Overexpression of regucalcin modulates tumor-related gene expression in cloned rat hepatoma H4-II-E cells.
Carcinoma, Hepatocellular
Overexpression of regucalcin suppresses apoptotic cell death in the cloned rat hepatoma H4-II-E cells induced by a naturally occurring isothiocyanate sulforaphane.
Carcinoma, Hepatocellular
Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by insulin or insulin-like growth factor-I.
Carcinoma, Hepatocellular
Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by lipopolysaccharide, PD 98059, dibucaine, or Bay K 8644.
Carcinoma, Hepatocellular
Overexpression of regucalcin suppresses cell death in cloned rat hepatoma H4-II-E cells induced by tumor necrosis factor-alpha or thapsigargin.
Carcinoma, Hepatocellular
Overexpression of regucalcin suppresses cell proliferation in cloned rat hepatoma H4-II-E cells: involvement of intracellular signaling factors and cell cycle-related genes.
Carcinoma, Hepatocellular
Overexpression of regucalcin suppresses gene expression of insulin signaling-related proteins in cloned rat hepatoma H4-II-E cells: Involvement of insulin resistance.
Carcinoma, Hepatocellular
Promoter characterization of the rat gene for Ca2+-binding protein regucalcin. Transcriptional regulation by signaling factors.
Carcinoma, Hepatocellular
Regucalcin and cell regulation: role as a suppressor protein in signal transduction.
Carcinoma, Hepatocellular
Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats.
Carcinoma, Hepatocellular
Regulatory role of endogenous regucalcin in the enhancement of nuclear deoxyribonuleic acid synthesis with proliferation of cloned rat hepatoma cells (H4-II-E).
Carcinoma, Hepatocellular
Role of endogenous regucalcin in protein tyrosine phosphatase regulation in the cloned rat hepatoma cells (H4-II-E).
Carcinoma, Hepatocellular
Role of regucalcin in liver nuclear function: binding of regucalcin to nuclear protein or DNA and modulation of tumor-related gene expression.
Carcinoma, Hepatocellular
Role of regucalcin in maintaining cell homeostasis and function (review).
Carcinoma, Hepatocellular
Senescence marker protein 30 (SMP30) serves as a potential prognostic indicator in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells.
Carcinoma, Hepatocellular
Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Soluble expression of recombinant human SMP30 for detecting serum SMP30 antibody levels in hepatocellular carcinoma patients.
Carcinoma, Hepatocellular
Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue.
Carcinoma, Hepatocellular
Suppression of cell proliferation and deoxyribonucleic acid synthesis in the cloned rat hepatoma H4-II-E cells overexpressing regucalcin.
Carcinoma, Hepatocellular
Suppressive effect of endogenous regucalcin on nitric oxide synthase activity in cloned rat hepatoma H4-II-E cells overexpressing regucalcin.
Carcinoma, Hepatocellular
Suppressive role of endogenous regucalcin in the enhancement of protein kinase activity with proliferation of cloned rat hepatoma cells (H4-II-E).
Carcinoma, Hepatocellular
Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis.
Carcinoma, Hepatocellular
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Carcinoma, Hepatocellular
The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways.
Carcinoma, Hepatocellular
The calcium channel agonist Bay K 8644 promotes the growth of human liver cancer HepG2 cells in vitro: suppression with overexpressed regucalcin.
Carcinoma, Hepatocellular
Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin.
Carcinoma, Hepatocellular
Transcriptional regulation of human paraoxonase 1 by PXR and GR in human hepatoma cells.
Carcinoma, Non-Small-Cell Lung
Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy.
Carcinoma, Renal Cell
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro.
Cardiomegaly
Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction.
Cardiovascular Diseases
Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease.
Cardiovascular Diseases
PON1 lactonase activity and its association with cardiovascular disease.
Carotid Artery Diseases
Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease.
Cataract
Effect of senescence marker protein 30 on the proliferation and apoptosis of human lens epithelial cells SRA01/04.
Cataract
Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice.
Cataract
Expressions of Senescence-Associated ?-Galactosidase and Senescence Marker Protein-30 are Associated with Lens Epithelial Cell Apoptosis.
Colitis
Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity.
Colitis-Associated Neoplasms
Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity.
Colorectal Neoplasms
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Coronary Artery Disease
Mutations in the human paraoxonase 1 gene: frequencies, allelic linkages, and association with coronary artery disease.
Coronary Disease
Human paraoxonase 1 gene polymorphisms and the risk of coronary heart disease: a community-based study.
Coronary Disease
Low protective PON1 lactonase activity in an Arab population with high rates of coronary heart disease and diabetes.
Coronary Disease
Quantitative Assessment of the Influence of Paraoxonase 1 Activity and Coronary Heart Disease Risk.
Cystic Fibrosis
Paraoxonase 2 Serves a Proapopotic Function in Mouse and Human Cells in Response to the Pseudomonas aeruginosa Quorum-sensing Molecule N-(3-Oxododecanoyl)-homoserine Lactone.
Dementia
A Multi-Omics Analysis of PON1 Lactonase Activity in Relation to Human Health and Disease.
Dementia, Vascular
Melatonin ameliorates brain oxidative stress and upregulates senescence marker protein-30 and osteopontin in a rat model of vascular dementia.
Diabetes Mellitus
Effect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Rats.
Diabetes Mellitus
Paraoxonase lactonase activity, inflammation and antioxidant status in plasma of patients with type 1 diabetes mellitus.
Diabetes Mellitus
Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type I diabetes mellitus.
Diabetes Mellitus, Type 1
Paraoxonase lactonase activity, inflammation and antioxidant status in plasma of patients with type 1 diabetes mellitus.
Diabetes Mellitus, Type 2
Decreased paraoxonase 2 enzymatic activity in monocyte/macrophages cells. A comparative in vivo and in vitro study for diabetes.
Diabetes, Gestational
Lactonase activity and status of paraoxonase 1 and oxidative stress in neonates of women with gestational diabetes mellitus.
Diabetes, Gestational
Lactonase Activity, Status, and Genetic Variations of Paraoxonase 1 in Women with Gestational Diabetes Mellitus.
Diabetic Foot
Quorum Quenching Lactonase Strengthens Bacteriophage and Antibiotic Arsenal Against Pseudomonas aeruginosa Clinical Isolates.
Diabetic Nephropathies
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Diabetic Nephropathies
Kidney tissue proteomics reveals regucalcin downregulation in response to diabetic nephropathy with reflection in urinary exosomes.
Diabetic Nephropathies
Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type I diabetes mellitus.
Diabetic Nephropathies
Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes.
Fatty Liver
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Fatty Liver
Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.
Foot Ulcer
Quorum Quenching Lactonase Strengthens Bacteriophage and Antibiotic Arsenal Against Pseudomonas aeruginosa Clinical Isolates.
gluconolactonase deficiency
Age-related oxidant stress with senescence marker protein-30 deficiency plays a pivotal role in coronary artery spasm.
gluconolactonase deficiency
Anti-inflammatory activity of SMP30 modulates NF-?B through protein tyrosine kinase/phosphatase balance.
gluconolactonase deficiency
Coronary Artery Spasm Related to Thiol Oxidation and Senescence Marker Protein-30 in Aging.
gluconolactonase deficiency
Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion.
gluconolactonase deficiency
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
gluconolactonase deficiency
Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.
gluconolactonase deficiency
Senescence Marker Protein 30 Deficiency Exacerbates Pulmonary Hypertension in Hypoxia-Exposed Mice.
gluconolactonase deficiency
Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation.
gluconolactonase deficiency
Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity.
gluconolactonase deficiency
Senescence Marker Protein-30 (SMP30) Deficiency Impairs Myocardium-Induced Dilation of Coronary Arterioles Associated with Reactive Oxygen Species.
gluconolactonase deficiency
Senescence marker protein-30 deficiency impairs angiogenesis under ischemia.
gluconolactonase deficiency
Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes.
gluconolactonase deficiency
SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.
gluconolactonase deficiency
Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice.
Glucose Intolerance
Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.
Glucose Intolerance
Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion.
Glucose Metabolism Disorders
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Hearing Loss
Effect of vitamin C depletion on age-related hearing loss in SMP30/GNL knockout mice.
Heart Failure
Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review).
Hepatitis
Potential sensitivity of hepatic specific protein regucalcin as a marker of chronic liver injury.
Hepatitis B
Serum lactonase and arylesterase activities in alcoholic hepatitis and hepatitis B.
Hepatitis B
Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.
Hepatitis B, Chronic
Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.
Hepatitis, Alcoholic
Serum lactonase and arylesterase activities in alcoholic hepatitis and hepatitis B.
Hepatitis, Chronic
Diagnostic Value of Serum SMP30 and Anti-SMP30 Antibody in Hepatocellular Carcinoma.
Hyperlipidemias
Change in lipid components in the adipose and liver tissues of regucalcin transgenic rats with increasing age: suppression of leptin and adiponectin gene expression.
Hyperlipidemias
Exogenous regucalcin suppresses osteoblastogenesis and stimulates adipogenesis in mouse bone marrow culture.
Hyperlipidemias
Hyperlipidemia is induced in regucalcin transgenic rats with increasing age.
Hyperlipidemias
Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats.
Hypertension
Candidate gene polymorphisms related to lipid metabolism in Asian Indians living in Durban, South Africa.
Hypertension
Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes.
Hypertension, Pulmonary
Senescence Marker Protein 30 Deficiency Exacerbates Pulmonary Hypertension in Hypoxia-Exposed Mice.
Hyperthyroidism
Alterations in expression of senescence marker protein-30 gene by 3,3',5-triiodo-L-thyronine (T3).
Hypoalphalipoproteinemias
Paraoxonase-1 activities in individuals with different HDL circulating levels: Implication in reverse cholesterol transport and early vascular damage.
Infections
A preliminary study of paraoxonase-1 in infected patients with an indwelling central venous catheter.
Infections
Effects of dietary Lactobacillus plantarum and AHL lactonase on the control of Aeromonas hydrophila infection in tilapia.
Infections
In vivo evaluation of a recombinant N-acylhomoserine lactonase formulated in a hydrogel using a murine model infected with MDR Pseudomonas aeruginosa clinical isolate, CCASUP2.
Infections
Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma.
Infections
The Redox Systems of Plasmodium falciparum and Plasmodium vivax: Comparison, In silico Analyses and Inhibitor Studies.
Infertility
Detection and localization of regucalcin in spermatozoa of water buffalo (Bubalus bubalis): A calcium-regulating multifunctional protein.
Insulin Resistance
Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease.
Insulin Resistance
Overexpression of regucalcin enhances glucose utilization and lipid production in cloned rat hepatoma H4-II-E cells: Involvement of insulin resistance.
Insulin Resistance
Overexpression of regucalcin suppresses gene expression of insulin signaling-related proteins in cloned rat hepatoma H4-II-E cells: Involvement of insulin resistance.
Insulin Resistance
Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.
Insulin Resistance
Paraoxonase-1 (PON1) Status in Pancreatic Cancer: Relation to Clinical Parameters.
Insulin Resistance
Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats.
Insulin Resistance
Study of Cellular Senescence and Vitamin D Deficiency in Nonalcoholic Fatty Liver Disease and The Potential Protective Effect of Vitamin D Supplementation.
Kidney Diseases
Kidney tissue proteomics reveals regucalcin downregulation in response to diabetic nephropathy with reflection in urinary exosomes.
Kidney Failure, Chronic
Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease.
Kidney Failure, Chronic
Effect of nutritional status on human paraoxonase-1 activity in patients with chronic kidney disease.
Kidney Failure, Chronic
Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy.
Kidney Failure, Chronic
Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis.
Kidney Neoplasms
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro.
Liver Cirrhosis
Diagnostic Value of Serum SMP30 and Anti-SMP30 Antibody in Hepatocellular Carcinoma.
Liver Cirrhosis
Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats.
Liver Cirrhosis
Senescence Marker Protein 30: Functional and Structural Insights to its Unknown Physiological Function.
Liver Cirrhosis
Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice.
Liver Diseases
Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease.
Liver Diseases
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Liver Diseases
Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.
Liver Diseases
Serum lactonase and arylesterase activities in alcoholic hepatitis and hepatitis B.
Liver Diseases
Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.
Liver Diseases
The measurement of the lactonase activity of paraoxonase-1 in the clinical evaluation of patients with chronic liver impairment.
Liver Failure, Acute
Senescence marker protein 30 in acute liver failure: validation of a mass spectrometry proteomics assay.
Liver Neoplasms
Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver.
Liver Neoplasms
Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro.
Liver Neoplasms
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Liver Neoplasms
SP1 suppresses phorbol 12-myristate 13-acetate induced up-regulation of human regucalcin expression in liver cancer cells.
Liver Neoplasms
The calcium channel agonist Bay K 8644 promotes the growth of human liver cancer HepG2 cells in vitro: suppression with overexpressed regucalcin.
Liver Neoplasms, Experimental
Expression of calcium-binding protein regucalcin mRNA in hepatoma cells.
Lung Neoplasms
Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy.
Lung Neoplasms
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Metabolic Diseases
Regucalcin as a potential biomarker for metabolic and neuronal diseases.
Metabolic Syndrome
Ciprofibrate increases paraoxonase activity in patients with metabolic syndrome.
Neoplasm Metastasis
Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma.
Neoplasms
17?-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30.
Neoplasms
2,3,7,8?Tetrachlorodibenzo?p?dioxin suppresses the growth of human liver cancer HepG2 cells in vitro: Involvement of cell signaling factors.
Neoplasms
Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence.
Neoplasms
Alternatively spliced variants of the regucalcin gene in various human normal and tumor tissues.
Neoplasms
Crosstalk Between Adipokines and Paraoxonase 1: A New Potential Axis Linking Oxidative Stress and Inflammation.
Neoplasms
Exogenous regucalcin negatively regulates the progression of cervical adenocarcinoma.
Neoplasms
Exogenous regucalcin stimulates osteoclastogenesis and suppresses osteoblastogenesis through NF-?B activation.
Neoplasms
Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro.
Neoplasms
Exogenous regucalcin suppresses the proliferation of human breast cancer MDA-MB-231 bone metastatic cells in vitro.
Neoplasms
Extracellular regucalcin suppresses colony formation and growth independent of tumor suppressor p53 in human mammary epithelial cells.
Neoplasms
Growth inhibition of cultured human liver carcinoma cells by Ki-energy (life-energy): scientific evidence for Ki-effects on cancer cells.
Neoplasms
Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis.
Neoplasms
Hormonal regulation of regucalcin mRNA expression in osteoblastic MC3T3-E1 cells.
Neoplasms
Increased regucalcin gene expression extends survival in breast cancer patients: Overexpression of regucalcin suppresses the proliferation and metastatic bone activity in MDA-MB-231 human breast cancer cells in vitro.
Neoplasms
Inhibition of SMP30 Gene Expression Influences the Biological Characteristics of Human Hep G2 Cells.
Neoplasms
Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy.
Neoplasms
Laminarin from Seaweed (Laminaria japonica) Inhibits Hepatocellular Carcinoma Through Upregulating Senescence Marker Protein-30.
Neoplasms
Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy.
Neoplasms
Overexpression of regucalcin modulates tumor-related gene expression in cloned rat hepatoma H4-II-E cells.
Neoplasms
Overexpression of regucalcin suppresses cell death in cloned rat hepatoma H4-II-E cells induced by tumor necrosis factor-alpha or thapsigargin.
Neoplasms
Overexpression of regucalcin suppresses cell response for tumor necrosis factor-alpha or transforming growth factor-beta1 in cloned normal rat kidney proximal tubular epithelial NRK52E cells.
Neoplasms
Overexpression of Regucalcin Suppresses the Growth of Human Osteosarcoma Cells in Vitro: Repressive Effect of Extracellular Regucalcin.
Neoplasms
Paraoxonase-1 (PON1) Status in Pancreatic Cancer: Relation to Clinical Parameters.
Neoplasms
Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells.
Neoplasms
Prolonged survival in hepatocarcinoma patients with increased regucalcin gene expression: HepG2 cell proliferation is suppressed by overexpression of regucalcin in vitro.
Neoplasms
Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro.
Neoplasms
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Neoplasms
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro.
Neoplasms
Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones.
Neoplasms
Senescence marker protein 30 (SMP30) serves as a potential prognostic indicator in hepatocellular carcinoma.
Neoplasms
Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish.
Neoplasms
Senescence Marker Protein 30: Functional and Structural Insights to its Unknown Physiological Function.
Neoplasms
Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis.
Neoplasms
Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells.
Neoplasms
Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma.
Neoplasms
Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro.
Neoplasms
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Neoplasms
Targeting ?-catenin in hepatocellular cancers induced by coexpression of mutant ?-catenin and K-Ras in mice.
Neoplasms
The calcium channel agonist Bay K 8644 promotes the growth of human liver cancer HepG2 cells in vitro: suppression with overexpressed regucalcin.
Neurodegenerative Diseases
Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation.
Neurodegenerative Diseases
Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis.
Non-alcoholic Fatty Liver Disease
Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Involvement of regucalcin in lipid metabolism and diabetes.
Non-alcoholic Fatty Liver Disease
Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.
Non-alcoholic Fatty Liver Disease
Study of Cellular Senescence and Vitamin D Deficiency in Nonalcoholic Fatty Liver Disease and The Potential Protective Effect of Vitamin D Supplementation.
Obesity
A Multi-Omics Analysis of PON1 Lactonase Activity in Relation to Human Health and Disease.
Obesity
Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women.
Obesity
Involvement of regucalcin gene promoter region-related protein-p117, a transcription factor, in human obesity.
Obesity, Abdominal
Anti-atherogenic properties of high-density lipoproteins in psychiatric patients before and after two months of atypical anti-psychotic therapy.
Obesity, Morbid
Increased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile.
Osteoporosis
Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats.
Osteoporosis
Senescence Marker Protein 30: Functional and Structural Insights to its Unknown Physiological Function.
Osteosarcoma
Overexpression of Regucalcin Suppresses the Growth of Human Osteosarcoma Cells in Vitro: Repressive Effect of Extracellular Regucalcin.
Overweight
Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women.
Overweight
Paraoxonase, arylesterase and lactonase activities of paraoxonase-1 (PON1) in obese and severely obese women.
Pancreatic Neoplasms
Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro.
Pancreatic Neoplasms
Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.
Pancreatic Neoplasms
Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro.
Pancreatic Neoplasms
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
Parkinson Disease
Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation.
Pneumonia
An antifouling peptide-based biosensor for determination of Streptococcus pneumonia markers in human serum.
Pneumonia
Inhaled lactonase reduces Pseudomonas aeruginosa quorum sensing and mortality in rat pneumonia.
Polycystic Ovary Syndrome
Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis.
Prostatic Neoplasms
Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells.
Prostatic Neoplasms
Regucalcin is expressed in rat mammary gland and prostate and down-regulated by 17beta-estradiol.
Prostatic Neoplasms
Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones.
Prostatic Neoplasms
Suppressed glycolytic metabolism in the prostate of transgenic rats overexpressing calcium-binding protein regucalcin underpins reduced cell proliferation.
Prostatic Neoplasms
Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis.
Pulmonary Emphysema
Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice.
Pulmonary Emphysema
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.
Renal Insufficiency
Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease.
Renal Insufficiency
The potential role of regucalcin in kidney cell regulation: Involvement in renal failure (Review).
Renal Insufficiency, Chronic
Circulating Lactonase Activity but Not Protein Level of PON-1 Predicts Adverse Outcomes in Subjects with Chronic Kidney Disease.
Retinoblastoma
2,3,7,8?tetrachlorodibenzo?p?dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling.
Retinoblastoma
Extracellular regucalcin suppresses colony formation and growth independent of tumor suppressor p53 in human mammary epithelial cells.
Retinoblastoma
The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro.
Retinoblastoma
The phytochemical p-hydroxycinnamic acid suppresses the growth and stimulates the death in human liver cancer HepG2 cells.
Scurvy
Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy.
Spasm
Age-related oxidant stress with senescence marker protein-30 deficiency plays a pivotal role in coronary artery spasm.
Spasm
Coronary Artery Spasm Related to Thiol Oxidation and Senescence Marker Protein-30 in Aging.
Starvation
Gene transcription during exposure to, and recovery from, cold and desiccation stress in Drosophila melanogaster.
Starvation
The role of Rsv1 in the transcriptional regulation of genes involved in sugar metabolism for long-term survival.
Thrombosis
Circulating Fibroblast Growth Factor-23 Level and Paraoxonase-1 Lactonase Activity in Chronic Hemodialysis Patients: Their Impact on the Incidence of Native AV Fistula Thrombosis.
Uremia
Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis.
Wound Infection
Efficacy of purified lactonase and ciprofloxacin in preventing systemic spread of Pseudomonas aeruginosa in murine burn wound model.
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