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Disease on EC 3.1.1.106 - O-acetyl-ADP-ribose deacetylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.
Carcinogenesis
Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes.
MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults.
The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis.
Carcinoma, Hepatocellular
MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3?/?-catenin signaling.
Colonic Neoplasms
MACROD2 expression predicts response to 5-FU-based chemotherapy in stage III colon cancer.
Colorectal Neoplasms
Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes.
MACROD2 deletions cause impaired PARP1 activity and chromosome instability in colorectal cancer.
MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults.
Fatty Liver
Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality.
Graves Disease
Association of Polymorphisms in MACRO Domain Containing 2 With Thyroid-Associated Orbitopathy.
Insulin Resistance
High Genetic Risk Scores of ASIC2, MACROD2, CHRM3, and C2orf83 Genetic Variants Associated with Polycystic Ovary Syndrome Impair Insulin Sensitivity and Interact with Energy Intake in Korean Women.
Intellectual Disability
Intragenic Deletion in MACROD2: A Family with Complex Phenotypes Including Microcephaly, Intellectual Disability, Polydactyly, Renal and Pancreatic Malformations.
Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults.
Microcephaly
Intragenic Deletion in MACROD2: A Family with Complex Phenotypes Including Microcephaly, Intellectual Disability, Polydactyly, Renal and Pancreatic Malformations.
Neoplasm Metastasis
MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3?/?-catenin signaling.
MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.
Neoplasms
Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes.
MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria.
MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3?/?-catenin signaling.
MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.
MACROD2, an Original Cause of CIN?
Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults.
The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis.
Two Distinct Categories of Focal Deletions in Cancer Genomes.
Neuroblastoma
Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome.
o-acetyl-adp-ribose deacetylase deficiency
MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3?/?-catenin signaling.
Obesity
Association of MACROD2 gene variants with obesity and physical activity in a Korean population.
Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults.
Papilloma
Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site.
Polycystic Ovary Syndrome
High Genetic Risk Scores of ASIC2, MACROD2, CHRM3, and C2orf83 Genetic Variants Associated with Polycystic Ovary Syndrome Impair Insulin Sensitivity and Interact with Energy Intake in Korean Women.
Polydactyly
Intragenic Deletion in MACROD2: A Family with Complex Phenotypes Including Microcephaly, Intellectual Disability, Polydactyly, Renal and Pancreatic Malformations.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.
Tongue Neoplasms
PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.
Uterine Cervical Neoplasms
Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site.