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IUBMB Comments The enzyme, isolated from the bacterium Ideonella sakaiensis , has no activity with poly(ethylene terephthalate) PET (cf . EC 3.1.1.101 , poly(ethylene terephthalate) hydrolase).
The enzyme appears in viruses and cellular organisms
Synonyms mhetase, mhet hydrolase, mono(2-hydroxyethyl) terephthalate hydrolase, more
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mono(2-hydroxyethyl) terephthalate hydrolase
ISF6_0224
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MHETase
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mono(2-hydroxyethyl) terephthalate hydrolase
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mono(2-hydroxyethyl) terephthalate hydrolase
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4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = terephthalate + ethylene glycol
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-
-
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MetaCyc
polyethylene terephthalate degradation
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4-[(2-hydroxyethoxy)carbonyl]benzoate acylhydrolase
The enzyme, isolated from the bacterium Ideonella sakaiensis, has no activity with poly(ethylene terephthalate) PET (cf. EC 3.1.1.101, poly(ethylene terephthalate) hydrolase).
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bis(2-hydroxyethyl) terephthalic acid + 2 H2O
terephthalic acid + 2 ethylene glycol
E5BBQ3
Substrates: - Products: -
?
ethylene terephthalate + H2O
terephthalate + ethylene glycol
additional information
?
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ethylene terephthalate + H2O
terephthalate + ethylene glycol
Substrates: - Products: -
?
ethylene terephthalate + H2O
terephthalate + ethylene glycol
Substrates: - Products: -
?
ethylene terephthalate + H2O
terephthalate + ethylene glycol
E5BBQ3
Substrates: - Products: -
?
additional information
?
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Substrates: no substrates: poly(ethylene terephthalate), bis(2-hydroxyethyl) terephthalic acid or 4-nitrophenyl aliphatic esters Products: -
?
additional information
?
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Substrates: no substrates: poly(ethylene terephthalate), bis(2-hydroxyethyl) terephthalic acid or 4-nitrophenyl aliphatic esters Products: -
?
additional information
?
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E5BBQ3
Substrates: enzyme additionally catalyzes hydrolysis of poly(ethylene terephthalate), reaction of EC 3.1.1.101 Products: -
?
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bis(2-hydroxyethyl) terephthalic acid
E5BBQ3
competitive inhibition of the hydrolytic activity against PET nanoparticles
ethylene terephthalate
E5BBQ3
competitive inhibition of the hydrolytic activity against PET nanoparticles
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3.9
bis(2-hydroxyethyl) terephthalic acid
E5BBQ3
pH 8.5, 60°C
0.0073 - 7.3
ethylene terephthalate
0.0073
ethylene terephthalate
pH 7.0, 30°C
7.3
ethylene terephthalate
E5BBQ3
pH 8.5, 60°C
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26.8
bis(2-hydroxyethyl) terephthalic acid
E5BBQ3
pH 8.5, 60°C
0.31 - 31
ethylene terephthalate
0.31
ethylene terephthalate
E5BBQ3
pH 8.5, 60°C
31
ethylene terephthalate
pH 7.0, 30°C
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UniProt
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UniProt
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cf. EC 3.1.1.74
E5BBQ3
UniProt
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Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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MHETH_IDESA
Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)
603
0
63103
Swiss-Prot
-
B1G327_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
575
0
60831
TrEMBL
-
A0A6J5F7D9_9BURK
263
0
28900
TrEMBL
-
A0A663BH44_9ENTR
324
0
35485
TrEMBL
-
A0A6S7B2U3_9BURK
588
0
62452
TrEMBL
-
A0A554WIU4_9BURK
574
0
62054
TrEMBL
-
A0A1X1PM24_9BURK
574
0
59126
TrEMBL
-
A0A653Y0R3_9GAMM
528
0
56477
TrEMBL
-
A0A6J4ZUJ9_9BURK
569
0
58788
TrEMBL
-
A0A5E6YN35_PSEFL
583
0
62103
TrEMBL
-
A0A5E7LM26_PSEFL
549
0
58442
TrEMBL
-
A0A2N7W7Z2_9BURK
562
0
58385
TrEMBL
-
A0A5E6YM10_PSEFL
524
0
56788
TrEMBL
-
B1FZP5_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
565
1
60282
TrEMBL
-
A0A6J5DFN4_9BURK
594
1
63491
TrEMBL
-
A0A833VAL8_BURGA
554
0
59712
TrEMBL
-
A0A6J5DMX4_9BURK
573
0
58917
TrEMBL
-
A0A833Q1G4_BURGA
544
0
56440
TrEMBL
-
A0A8B6IV45_9ENTR
586
1
63618
TrEMBL
-
A0A2R8CH46_9GAMM
579
0
62877
TrEMBL
-
A0A2R8CG46_9RHOB
523
0
56413
TrEMBL
-
A0A6J5FRN3_9BURK
505
0
52813
TrEMBL
-
A0A7U7EDM9_PSEST
571
0
61301
TrEMBL
-
A0A5E7CZC2_PSEFL
573
0
62041
TrEMBL
-
A0A2R8CAB2_9RHOB
523
0
55981
TrEMBL
-
A0A6J5B0A2_9BURK
551
0
57362
TrEMBL
-
B1FSY9_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
568
0
58933
TrEMBL
-
A0A3S4QU82_PSEST
559
0
60843
TrEMBL
-
A0A6J4ZXS4_9BURK
575
0
59319
TrEMBL
-
B1FYE6_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
551
0
57396
TrEMBL
-
A0A2N7WT19_9BURK
561
1
60139
TrEMBL
-
A0A6J5FTZ5_9BURK
557
0
59659
TrEMBL
-
A0A6J5AHH5_9BURK
560
0
59937
TrEMBL
-
A0A6J5KA99_9BURK
543
0
58213
TrEMBL
-
A0A6J5K194_9BURK
569
0
58764
TrEMBL
-
A0A2N7WIJ2_9BURK
568
0
58987
TrEMBL
-
A0A508SWH9_9BRAD
576
1
61244
TrEMBL
-
A0A6G8NJD7_9BURK
547
0
58685
TrEMBL
-
A0A6J5KBT9_9BURK
551
0
57304
TrEMBL
-
A0A6J5CN90_9BURK
543
0
58240
TrEMBL
-
A0A385XYT8_9GAMM
367
0
40709
TrEMBL
-
A0A6J5FX66_9BURK
586
1
61450
TrEMBL
-
A0A6J5CDR5_9BURK
514
1
52138
TrEMBL
-
A0A6J5K7F0_9BURK
613
1
63781
TrEMBL
-
A0A7T6XAS5_RALPI
582
0
59805
TrEMBL
-
A0A6S7AZ84_9BURK
558
1
59971
TrEMBL
-
A0A7K0C3G9_9ACTN
538
0
56396
TrEMBL
-
A0A833Q4G3_BURGA
573
0
59276
TrEMBL
-
A0A2H5Z607_9BACT
520
0
56850
TrEMBL
-
A0A6S7BQ61_9BURK
586
1
60955
TrEMBL
-
A0A6J5GJP1_9BURK
576
0
59313
TrEMBL
-
A0A7K0BXE1_9ACTN
530
1
57271
TrEMBL
-
A0A833Q1W9_BURGA
622
0
63416
TrEMBL
-
B1G824_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
562
0
58369
TrEMBL
-
A0A2H5Z055_9BACT
439
0
47603
TrEMBL
-
A0A385ZZQ5_9ACTN
539
0
57114
TrEMBL
-
A0A6J5GMP7_9BURK
166
0
17849
TrEMBL
-
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degradation
enzyme shows good activity against commercial bottle-derived PET, which is highly crystallized and is considerably active against PET film at low temperatures
degradation
-
enzyme shows good activity against commercial bottle-derived PET, which is highly crystallized and is considerably active against PET film at low temperatures
-
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Barth, M.; Oeser, T.; Wei, R.; Then, J.; Schmidt, J.; Zimmermann, W.
Effect of hydrolysis products on the enzymatic degradation of polyethylene terephthalate nanoparticles by a polyester hydrolase from Thermobifida fusca
Biochem. Eng. J.
93
222-228
2015
Thermobifida fusca (E5BBQ3)
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Yoshida, S.; Hiraga, K.; Takehana, T.; Taniguchi, I.; Yamaji, H.; Maeda, Y.; Toyohara, K.; Miyamoto, K.; Kimura, Y.; Oda, K.
A bacterium that degrades and assimilates poly(ethylene terephthalate)
Science
351
1196-1199
2016
Ideonella sakaiensis (A0A0K8P8E7), Ideonella sakaiensis 201-F6 (A0A0K8P8E7)
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