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EC Tree
IUBMB Comments Propanoyl-CoA, acetyl-CoA, butanoyl-CoA and some other acyl-CoAs can act as substrates, but more slowly than 5-hydroxypentanoyl-CoA.
The expected taxonomic range for this enzyme is: Anaerocolumna aminovalerica
Synonyms
5-hydroxyvalerate CoA-transferase, 5-hydroxyvalerate coenzyme A-transferase,
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5-hydroxyvalerate CoA-transferase
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5-hydroxyvalerate coenzyme A-transferase
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acetyl-CoA + 5-hydroxypentanoate = acetate + 5-hydroxypentanoyl-CoA
propanoyl-CoA, acetyl-CoA, butanoyl-CoA and some other acyl-CoAs can act as substrates, but more slowly than 5-hydroxypentanoyl-CoA
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coenzyme A transfer
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acetyl-CoA:5-hydroxypentanoate CoA-transferase
Propanoyl-CoA, acetyl-CoA, butanoyl-CoA and some other acyl-CoAs can act as substrates, but more slowly than 5-hydroxypentanoyl-CoA.
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5-hydroxypentanoyl-CoA + acetate
acetyl-CoA + 5-hydroxypentanoate
acetate + (Z)-5-hydroxypentenoyl-CoA
acetyl-CoA + (Z)-5-hydroxypentenoate
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-
?
acetyl-CoA + (Z)-5-hydroxy-2-pentenoate
acetate + (Z)-5-hydroxy-2-pentenoyl-CoA
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r
acetyl-CoA + 3-pentenoate
acetate + 3-pentenoyl-CoA
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?
acetyl-CoA + 4-pentenoate
acetate + 4-pentenoyl-CoA
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?
acetyl-CoA + 5-hydroxypentanoate
acetate + 5-hydroxypentanoyl-CoA
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r
acetyl-CoA + acetate
acetyl-CoA + acetate
acetyl-CoA + propionate
acetate + propanoyl-CoA
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r
butyryl-CoA + (Z)-5-hydroxy-2-pentenoate
butyrate + (Z)-5-hydroxy-2-pentenoyl-CoA
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?
butyryl-CoA + acetate
acetyl-CoA + butanoate
pentanoyl-CoA + (Z)-5-hydroxy-2-pentenoate
pentanoate + (Z)-5-hydroxy-2-pentenoyl-CoA
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?
pentanoyl-CoA + acetate
acetyl-CoA + pentanoate
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?
propionyl-CoA + (Z)-5-hydroxy-2-pentenoate
propionate + (Z)-5-hydroxy-2-pentenoyl-CoA
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?
propionyl-CoA + acetate
acetyl-CoA + propanoate
additional information
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5-hydroxypentanoyl-CoA + acetate
acetyl-CoA + 5-hydroxypentanoate
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?
5-hydroxypentanoyl-CoA + acetate
acetyl-CoA + 5-hydroxypentanoate
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?
acetyl-CoA + acetate
acetyl-CoA + acetate
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?
acetyl-CoA + acetate
acetyl-CoA + acetate
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?
butyryl-CoA + acetate
acetyl-CoA + butanoate
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?
butyryl-CoA + acetate
acetyl-CoA + butanoate
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?
propionyl-CoA + acetate
acetyl-CoA + propanoate
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r
propionyl-CoA + acetate
acetyl-CoA + propanoate
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r
additional information
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all substrates are bond in a (Z)-2,3-conformation to the enzyme, crotonate, (E)-5-hydroxy-2-pentenoate, (E)-2-pentenoate and 2,4-pentadienoate are no substrates
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additional information
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all substrates are bond in a (Z)-2,3-conformation to the enzyme, crotonate, (E)-5-hydroxy-2-pentenoate, (E)-2-pentenoate and 2,4-pentadienoate are no substrates
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5-hydroxypentanoyl-CoA + acetate
acetyl-CoA + 5-hydroxypentanoate
5-hydroxypentanoyl-CoA + acetate
acetyl-CoA + 5-hydroxypentanoate
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?
5-hydroxypentanoyl-CoA + acetate
acetyl-CoA + 5-hydroxypentanoate
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?
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Sodium boranate
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only in presence of a CoA substrate
additional information
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not inhibited by AMP
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4
(Z)-5-hydroxy-2-pentenoate
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pH 8.0, 25°C, cosubstrate acetyl-CoA
0.03
(Z)-5-hydroxypentenoyl-CoA
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pH 8.0, 25°C, cosubstrate acetate
0.0038 - 0.1
5-hydroxypentanoyl-CoA
20
acetate
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pH 8.0, 25°C, cosubstrate propionyl-CoA
0.018
acetyl-CoA
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pH 8.0, 25°C, cosubstrate (Z)-5-hydroxy-2-pentenoate
0.037 - 0.45
pentanoyl-CoA
0.009 - 0.12
propionyl-CoA
0.0038
5-hydroxypentanoyl-CoA
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pH 8.0, 25°C, cosubstrate (Z)-5-hydroxy-2-pentenoate
0.1
5-hydroxypentanoyl-CoA
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pH 8.0, 25°C, cosubstrate acetate
0.029
butyryl-CoA
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pH 8.0, 25°C, cosubstrate (Z)-5-hydroxy-2-pentenoate
0.07
butyryl-CoA
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pH 8.0, 25°C, cosubstrate acetate
0.037
pentanoyl-CoA
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pH 8.0, 25°C, cosubstrate (Z)-5-hydroxy-2-pentenoate
0.45
pentanoyl-CoA
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pH 8.0, 25°C, cosubstrate acetate
0.009
propionyl-CoA
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pH 8.0, 25°C, cosubstrate (Z)-5-hydroxy-2-pentenoate
0.12
propionyl-CoA
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pH 8.0, 25°C, acetate
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3
ATP
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pH 8.0, 25°C substrate acetate, non-competitive inhibition
3
ATP
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pH 8.0, 25°C substrate propionyl-CoA, competitive inhibition
5
ATP
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pH 8.0, 25°C substrate 5-hydroxypentanoyl-CoA, competitive inhibition
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T2-7
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brenda
T2-7
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brenda
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155000 - 160000
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gradient PAGE
178000
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average molecular mass
180000 - 195000
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gel filtration, Superose 6
47000
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4 * 47000, homotetramer, SDS-PAGE
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tetramer
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4 * 47000, homotetramer, SDS-PAGE
tetramer
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4 * 47000, homotetramer, SDS-PAGE
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-20°C, no loss of activity observed after storage for several months
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4°C, lose 50% of its activity within 2 months when kept in 20 mM potassium phosphate buffer, pH 6.8
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Eikmanns, U.; Buckel, W.
Properties of 5-hydroxyvalerate CoA-transferase from Clostridium aminovalericum
Biol. Chem. Hoppe-Seyler
371
1077-1082
1990
Anaerocolumna aminovalerica, Anaerocolumna aminovalerica T2-7
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History
2.8.3.14 5-hydroxypentanoate CoA-transferase
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